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BECN1 Gene

protein-coding   GIFtS: 66
GCID: GC17M040963

Beclin 1, Autophagy Related

(Previous names: beclin 1 (coiled-coil, moesin-like BCL2 interacting protein))
  See BECN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Beclin 1, Autophagy Related1 2     ATG6 Autophagy Related 6 Homolog2
Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein)1 2     Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein)2
Coiled-Coil Myosin-Like BCL2-Interacting Protein2 3     beclin-12
ATG6 Autophagy Related 6 Homolog (S. Cerevisiae)1     beclin12
ATG62     GT1973
VPS302     Protein GT1973

External Ids:    HGNC: 10341   Entrez Gene: 86782   Ensembl: ENSG000001265817   OMIM: 6043785   UniProtKB: Q144573   

Export aliases for BECN1 gene to outside databases

Previous GC identifers: GC17P040655 GC17M043124 GC17M040870 GC17M041335 GC17M038215 GC17M036726


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BECN1 Gene:
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and
neurodegeneration (Zhong et al., 2009 (PubMed 19270693)).(supplied by OMIM, Jul 2010)

GeneCards Summary for BECN1 Gene:
BECN1 (beclin 1, autophagy related) is a protein-coding gene. Diseases associated with BECN1 include nephropathic cystinosis.

UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457
Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in
antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus

Gene Wiki entry for BECN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the BECN1 gene promoter:
         GR   p53   AP-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBECN1 promoter sequence
   Search Chromatin IP Primers for BECN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BECN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

BECN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BECN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040963:  view genomic region     (about GC identifiers)

Start:
40,962,150 bp from pter      End:
40,985,367 bp from pter
Size:
23,218 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457 (See protein sequence)
Recommended Name: Beclin-1  
Size: 450 amino acids; 51896 Da
Subunit: Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either
UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct
competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing
Rubicon down-regulates autophagy (By similarity). Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts
with PIK3CB (By similarity). Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1
5 PDB 3D structures from and Proteopedia for BECN1:
2P1L (3D)        2PON (3D)        3DVU (3D)        4DDP (3D)        4MI8 (3D)    
Secondary accessions: B2R6N7 O75595 Q9UNA8

Explore the universe of human proteins at neXtProt for BECN1: NX_Q14457

Explore proteomics data for BECN1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of
    autophagy1
  • polyubiquitinated by NEDD4, both with 'Lys11'- and 'Lys63'-linkages. 'Lys'-11-linked poyubiquitination leads to
    degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted. Deubiquitinated by USP10
    and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes1
  • Ubiquitination2 at Lys32
  • Modification sites at PhosphoSitePlus

  • See BECN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003757.1  
    ENSEMBL proteins: 
     ENSP00000355231   ENSP00000465364   ENSP00000468597   ENSP00000416173   ENSP00000466419  
     ENSP00000468104   ENSP00000465964   ENSP00000466281   ENSP00000468700   ENSP00000468461  
     ENSP00000466766   ENSP00000465658   ENSP00000467937   ENSP00000467597  

    BECN1 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for BECN1
    Cloud-Clone Corp. Proteins for BECN1

     
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    antibodies-online proteins for BECN1 (12 products) 

     
    antibodies-online peptides for BECN1

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    antibodies-online antibodies for BECN1 (222 products) 

    BECN1 Assay Products:

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    antibodies-online kits for BECN1 (30 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007243 Beclin_fam

    Graphical View of Domain Structure for InterPro Entry Q14457

    ProtoNet protein and cluster: Q14457

    1 Blocks protein domain: IPB007243 Autophagy protein Apg6

    UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457
    Similarity: Belongs to the beclin family


    Find genes that share domains with BECN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BECN1_HUMAN, Q14457
    Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in
    antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus

         Genatlas biochemistry entry for BECN1:
    beclin 1,myosin-like BCL2-interacting protein,potentially involved in antiviral host defense,deleted in breast
    cancer cell lines

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16417406
    GO:0043565sequence-specific DNA binding ----
         
    Find genes that share ontologies with BECN1           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Becn1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  reproductive system  tumorigenesis 

    Find genes that share phenotypes with BECN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BECN1: Becn1tm1Blev Becn1tm1.1Ebr Becn1tm1Htz

       genOway: Develop your customized and physiologically relevant rodent model for BECN1

    miRNA
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    miRTarBase miRNAs that target BECN1:
    hsa-mir-100-5p (MIRT048553), hsa-mir-30a-5p (MIRT004509)

    Block miRNA regulation of human, mouse, rat BECN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BECN1 (see all 42):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-570 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidBECN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BECN1
    Predesigned siRNA for gene silencing in human, mouse, rat BECN1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for BECN1

    Clone
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    OriGene clones in human, mouse for BECN1 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: BECN1 (NM_003766)
    Sino Biological Human cDNA Clone for BECN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BECN1
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    Addgene plasmids for BECN1 

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12186) for BECN1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BECN1_HUMAN, Q14457: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction
    with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar
    Purkinje cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole4
    golgi apparatus3
    lysosome3
    cytosol2
    endoplasmic reticulum2
    endosome2
    mitochondrion2
    nucleus2
    cytoskeleton1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with BECN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BECN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy
    2Regulation of autophagy
    Regulation of autophagy
    3Apoptosis and Autophagy
    Apoptosis and Autophagy
    4Akt Signaling Pathway
    Akt Signaling Pathway


    Find genes that share SuperPaths with BECN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BECN1
        Akt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for BECN1
        Apoptosis and Autophagy

    3 GeneGo (Thomson Reuters) Pathways for BECN1
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Apoptosis and survival BAD phosphorylation
    Immune response TLR signaling pathways

    1 BioSystems Pathway for BECN1
        Senescence and Autophagy



    1 Kegg Pathway  (Kegg details for BECN1):
        Regulation of autophagy

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BECN1: 
              Autophagy in human mouse rat
              Apoptosis 384HT in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BECN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BECN1 (Q144571, 2, 3 ENSP000003552314) via UniProtKB, MINT, STRING, and/or I2D (see all 544)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104151, 2, 3, ENSP000003296234EBI-949378,EBI-77694 MINT-8182780 MINT-4821014 MINT-4820784 MINT-8095220 MINT-8182706 MINT-7014531 MINT-7712827 MINT-8095201 I2D: score=4 STRING: ENSP00000329623
    TAB3Q8N5C81, 2, ENSP000002884224EBI-949378,EBI-359964 MINT-8303905 MINT-8304506 MINT-8303946 MINT-8304392 MINT-8304450 MINT-8327871 MINT-8304232 MINT-8304218 MINT-8304320 STRING: ENSP00000288422
    TAB2Q9NYJ81, 2, ENSP000002863324EBI-949378,EBI-358708 MINT-8304485 MINT-8304201 MINT-8304465 MINT-8304359 MINT-8327865 MINT-8304411 MINT-8304433 MINT-8304337 MINT-8304183 MINT-8303924 MINT-8303890 STRING: ENSP00000286332
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IEA--
    GO:0000910cytokinesis IMP--
    GO:0001666response to hypoxia IEA--
    GO:0006914autophagy ----
    GO:0006968cellular defense response TAS9765397

    Find genes that share ontologies with BECN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BECN1

    Selected Novoseek inferred chemical compound relationships for BECN1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-methyladenine 92 11 17671202 (1), 18596087 (1), 18094609 (1), 18094523 (1) (see all 7)
    monodansylcadaverine 73.6 2 18484413 (1)
    rapamycin 63.6 4 19864570 (1), 19520853 (1), 19472400 (1), 18760364 (1)
    c2ceramide 59.4 2 16390869 (1), 14970205 (1)
    hydroxychloroquine 39.4 2 19357706 (1), 19749781 (1)
    ceramide 32.4 7 19337026 (3), 19060920 (3), 20406981 (1)
    arsenite 23.6 2 19577553 (1), 16882451 (1)
    inositol 1,4,5 trisphosphate 20.2 1 19325567 (1)
    oxygen 14 5 18281291 (1), 19959713 (1), 19901551 (1), 16857678 (1) (see all 5)
    cholesterol 0 4 17611388 (2), 17468177 (1)



    Find genes that share compounds with BECN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BECN1 gene: 
    NM_003766.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000361523(uc002ibo.3 uc010whc.1 uc002ibn.2) ENST00000590099
    ENST00000590764 ENST00000438274 ENST00000588276 ENST00000543382(uc010whb.1)
    ENST00000589663 ENST00000587880 ENST00000590185 ENST00000586589 ENST00000586754
    ENST00000589492 ENST00000590852 ENST00000593205 ENST00000589493 ENST00000591085
    ENST00000585515 ENST00000591307
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BECN1 (see all 42):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-570 hsa-miR-3167
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    Inhib. RNA
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    Selected AceView cDNA sequences (see all 355):

    AL549639 BU151146 H14439 BQ217763 BG742756 AW069223 AW305314 BM705418 
    C04377 BE889578 AA282669 AA912498 BI752969 BU156101 BM475727 CD366059 
    CA406492 BC010276 BU159476 BU153097 BE872158 AW515970 AA908175 AI568248 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BECN1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
    SP1:                          -           -     -           -     -     -     -                                         -                       -     -         
    SP2:              -           -           -     -           -     -     -     -                                                                                 
    SP3:                          -           -     -           -     -     -     -                                                                                 
    SP4:              -           -           -     -           -     -     -     -     -     -     -           -     -     -                                       
    SP5:                                                                                                                    -                       -     -     -   

    ExUns: 12a · 12b · 12c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for BECN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BECN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BECN1 Expression
    About this image


    BECN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
    BECN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BECN1 Protein Expression

    UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BECN1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BECN1 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Becn11 , 5 beclin 1, autophagy related1, 5 92.11(n)1
    98.44(a)1
      11 (64.58 cM)5
    562081  NM_019584.31  NP_062530.21 
     1012859525 
    chicken
    (Gallus gallus)
    Aves BECN11 beclin 1, autophagy related 79.12(n)
    92.39(a)
      420018  NM_001006332.1  NP_001006332.1 
    lizard
    (Anolis carolinensis)
    Reptilia BECN16
    beclin 1, autophagy related
    91(a)
    1 ↔ 1
    6(62274390-62291912)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ737390.12   -- 81.36(n)    BQ737390.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063319.12   -- 78.42(n)   393846  BC063319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54293
    Atg61
    Autophagy-specific gene 61 50(a)3
    58.13(n)1
    53.17(a)1
      95D103
    428501  NM_142952.31  NP_651209.11 
    worm
    (Caenorhabditis elegans)
    Secernentea bec-11 bec-1 44.08(n)
    32.23(a)
      177345  NM_068443.3  NP_500844.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS30(YPL120W)4
    VPS301
    Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes more4
    VPS301
    47.02(n)1
    35.11(a)1
      16(322071-323744)4
    8559831, 4  NP_015205.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATG61 ATG6 44.84(n)
    34.26(a)
      825344  NM_116036.3  NP_567116.1 
    rice
    (Oryza sativa)
    Liliopsida Os.248722 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.1(n)    AK101033.1 


    ENSEMBL Gene Tree for BECN1 (if available)
    TreeFam Gene Tree for BECN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BECN1 gene
    Selected SIMAP similar genes for BECN1 using alignment to 13 protein entries:     BECN1_HUMAN (see all proteins) (see all similar genes):
    PLEKHH2    ZNF737    DNMT1    AURA2    ZNF564    CTSS
    HMGA2    ZNF738    ZNF74    DCTN5    FKBP3    HKR1
    NF2    LYRM4    TMEM14B    UBIAD1    BECN1P1    C4orf22

    Find genes that share paralogs with BECN1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for BECN1
    PGOHUM00000245277 PGOHUM00000243666


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BECN1 (see all 293)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1112765281,2
    C,F--40964146(+) GCCTGC/TAATCC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1511126701,2
    --40964537(+) CCATCA/CTGGAT 1 -- int10--------
    rs620784521,2
    C--40964916(+) GGCGCG/AATCTC 1 -- int12Minor allele frequency- A:0.00NA CSA 3
    rs787093181,2
    C--40964960(+) CCATTC/TTCCTG 1 -- int10--------
    rs1468217681,2
    --40965102(+) TGTGAG/TCCACC 1 -- int10--------
    rs1116112701,2
    C--40965144(+) GGCGTA/GAGCCA 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs609148281,2
    C--40965166(+) CCTTTC/GCTTTC 1 -- int10--------
    rs1380546591,2
    --40965280(+) AGGCAC/TGGTGG 1 -- int10--------
    rs1495055001,2
    C--40965597(+) GGTCCC/TATTCC 1 -- int10--------
    rs1431989121,2
    --40965707(+) CTCACA/GGTGAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for BECN1 (40962150 - 40985367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BECN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833450CNV Loss17160897
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BECN1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604378    OMIM disorders: --

    1 disease for BECN1:    
    About MalaCards
    nephropathic cystinosis

    1 disease from the University of Copenhagen DISEASES database for BECN1:
    Cancer

    Find genes that share disorders with BECN1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BECN1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingolipidoses 57.3 4 17468177 (2), 17611388 (2)
    cancer 42.1 14 18184403 (2), 19060920 (2), 14657337 (1), 14638851 (1) (see all 8)
    tumors 39.7 52 20230646 (4), 14657337 (4), 11309306 (4), 16874027 (4) (see all 31)
    glioblastoma 26.2 3 19567133 (1), 19661320 (1), 19421400 (1)
    breast cancer 24.2 17 19762066 (5), 18829541 (2), 18184403 (1), 20230646 (1) (see all 9)
    glioma 18.1 3 20432283 (1), 19451193 (1), 19375507 (1), 19661320 (1)
    premalignant 15.9 1 14638851 (1)
    prostate cancer 14.6 2 20406981 (1), 10395800 (1)
    colon cancer 10.6 3 19066461 (2), 17595761 (1)
    ovarian cancer 10.4 3 11309306 (1), 17203225 (1), 10604474 (1)

    Genetic Association Database (GAD): BECN1
    Human Genome Epidemiology (HuGE) Navigator: BECN1 (2 documents)

    Export disorders for BECN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BECN1 gene, integrated from 10 sources (see all 314):
    (articles sorted by number of sources associating them with BECN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. (PubMed id 9765397)1, 2, 3 Liang X.H.... Levine B. (J. Virol. 1998)
    2. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. (PubMed id 10395800)1, 2, 9 Aita V.M.... Levine B. (Genomics 1999)
    3. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. (PubMed id 19180116)1, 2, 9 Zalckvar E.... Kimchi A. (EMBO Rep. 2009)
    4. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. (PubMed id 17337444)1, 2, 9 Oberstein A.... Shi Y. (J. Biol. Chem. 2007)
    5. Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin- 1. (PubMed id 17659302)1, 2, 9 Feng W.... Zhang M. (J. Mol. Biol. 2007)
    6. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. (PubMed id 19050071)1, 2, 9 Sun Q.... Zhong Q. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PubMed id 18843052)1, 2, 9 Itakura E.... Mizushima N. (Mol. Biol. Cell 2008)
    8. Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1. (PubMed id 21936852)1, 2 Platta H.W....Stenmark H. (Biochem. J. 2012)
    9. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PubMed id 21962518)1, 2 Liu J.... Yuan J. (Cell 2011)
    10. Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. (PubMed id 20697744)1, 4 Metzger S....Nguyen H.P. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8678 HGNC: 1034 AceView: BECN1 Ensembl:ENSG00000126581 euGenes: HUgn8678
    ECgene: BECN1 Kegg: 8678 H-InvDB: BECN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BECN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BECN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BECN1 gene:
    Search GeneIP for patents involving BECN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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