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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BECN1 Gene

protein-coding   GIFtS: 65
GCID: GC17M040963

beclin 1, autophagy related

(Previous names: beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)...)
 Explore 51 diseases affiliated with
BECN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BECN1    

Aliases
for BECN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Beclin 1, Autophagy Related1 2     Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein)2
ATG61 2     Beclin-11
VPS301 2     Beclin11
Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein)1 2     GT1973
Coiled-Coil Myosin-Like BCL2-Interacting Protein2 3     Protein GT1973
ATG6 Autophagy Related 6 Homolog2     

External Ids:    HGNC: 10341   Entrez Gene: 86782   Ensembl: ENSG000001265817   OMIM: 6043785   UniProtKB: Q144573   

Export aliases for BECN1 gene to outside databases

Previous GC identifers: GC17P040655 GC17M043124 GC17M040870 GC17M041335 GC17M038215 GC17M036726


Summaries
for BECN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BECN1:
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and
neurodegeneration (Zhong et al., 2009 (PubMed 19270693)).(supplied by OMIM, Jul 2010)

UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457
Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in
antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus

Gene Wiki entry for BECN1


Genomic Views
for BECN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BECN1 gene promoter:
         GR   p53   AP-1   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BECN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BECN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BECN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

BECN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BECN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040963:  view genomic region     (about GC identifiers)

Start:
 40,962,150 bp from pter      End:
 40,985,367 bp from pter
Size:
 23,218 bases      Orientation:
 minus strand

Proteins
for BECN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457 (See protein sequence)
Recommended Name: Beclin-1  
Size: 450 amino acids; 51896 Da
Subunit: Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG
and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for
BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates
autophagy (By similarity). Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB (By similarity).
Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with
ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells
(By similarity)
4 PDB 3D structures from and Proteopedia for BECN1:
2P1L (3D)        2PON (3D)        3DVU (3D)        4DDP (3D)    
Secondary accessions: O75595 Q9UNA8

Explore the universe of human proteins at neXtProt for BECN1: NX_Q14457

Post-translational modifications:

  • Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy1
  • Ubiquitinated. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14457

    • BECN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003757.1  
    ENSEMBL proteins: 
     ENSP00000355231   ENSP00000465364   ENSP00000468597   ENSP00000416173   ENSP00000466419  
     ENSP00000468104   ENSP00000465964   ENSP00000466281   ENSP00000468700   ENSP00000468461  
     ENSP00000466766   ENSP00000465658   ENSP00000467937   ENSP00000467597  

    Human Recombinant Protein Products: 
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    Novus Biologicals BECN1 Proteins
    Novus Biologicals BECN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BECN1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IEA--
    GO:0016020membrane IEA--


    BECN1 for ontologies           About GeneDecksing



    BECN1 Antibody Products: 
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    Abcam antibodies for BECN1 
    Uscn Antibodies for BECN1
    ThermoFisher Antibody for BECN1

    Assay Products for BECN1: 
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    Uscn ELISAs and CLIAs for BECN1

    Protein Domains /
    Families
    for BECN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BECN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007243 Beclin_fam

    Graphical View of Domain Structure for InterPro Entry Q14457

    ProtoNet protein and cluster: Q14457

    1 Blocks protein family: IPB007243 Autophagy protein Apg6

    UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457
    Similarity: Belongs to the beclin family


    Function
    for BECN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457
    Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in
    antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus

         Genatlas biochemistry entry for BECN1:
    beclin 1,myosin-like BCL2-interacting protein,potentially involved in antiviral host defense,deleted in breast cancer
    cell lines

    miRNA
    Products:            		miRTarBase miRNAs that target BECN1:
    hsa-mir-30a (MIRT004509)

    OriGene 3'-UTR Clone: BECN1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BECN1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate BECN1 (see all 42):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-570 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmid: BECN1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BECN1 (see all 7)
    OriGene shRNA RFP: BECN1
    OriGene siRNA: BECN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BECN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BECN1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BECN1 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BECN1 (NM_003766)
    Sino Biological Human cDNA Clone for BECN1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BECN1 

    Cell Line
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    Search LifeMap BioReagents cell lines for BECN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BECN1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    BECN1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for BECN1: Becn1tm1Blev Becn1tm1.1Ebr Becn1tm1Htz
         13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Becn1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     nervous system  reproductive system  tumorigenesis 

    BECN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BECN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Senescence and Autophagy
    		Senescence and Autophagy1.00
    3Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway
    		Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway1.00
    4Apoptosis and survival BAD phosphorylation
    		Apoptosis and survival_BAD phosphorylation0.99
    5Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    		Immune response_TLR signaling pathways0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BECN1
        Apoptosis and Autophagy

    3 GeneGo (Thomson Reuters) Pathways for BECN1
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Apoptosis and survival BAD phosphorylation
    Immune response TLR signaling pathways

    1 BioSystems Pathway for BECN1 
        Senescence and Autophagy


    1         Kegg Pathway  (Kegg details for BECN1):
        Regulation of autophagy


    BECN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BECN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/493 Interacting proteins for BECN1 (Q144571, 2, 3 ENSP000003552314) via UniProtKB, MINT, STRING, and/or I2D (see all 493)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104151, 2, 3, ENSP000003296234EBI-949378,EBI-77694 MINT-8182780 MINT-4821014 MINT-7712827 MINT-4820784 MINT-8095201 MINT-8095220 MINT-8182706 MINT-7014531 I2D: score=4 STRING: ENSP00000329623
    TAB2Q9NYJ82, ENSP000002863324MINT-8304485 MINT-8304201 MINT-8304465 MINT-8304359 MINT-8327865 MINT-8304411 MINT-8304337 MINT-8304433 MINT-8304183 MINT-8303924 MINT-8303890 STRING: ENSP00000286332
    TAB3Q8N5C82, ENSP000002884224MINT-8303905 MINT-8304506 MINT-8303946 MINT-8304392 MINT-8327871 MINT-8304450 MINT-8304232 MINT-8304218 MINT-8304320 STRING: ENSP00000288422
    ATG14Q6ZNE52, 3, ENSP000002471784MINT-8304715 I2D: score=5 STRING: ENSP00000247178
    BCL2L1Q078172, 3, ENSP000003025644MINT-7014585 I2D: score=4 STRING: ENSP00000302564
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IEA--
    GO:0000910cytokinesis IMP--
    GO:0001666response to hypoxia IEA--
    GO:0006914autophagy ----
    GO:0006968cellular defense response TAS9765397


    BECN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BECN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BECN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BECN1
    10/13 Novoseek chemical compound relationships for BECN1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-methyladenine 92 11 17671202 (1), 18596087 (1), 18094609 (1), 18094523 (1) (see all 7)
    monodansylcadaverine 73.6 2 18484413 (1)
    rapamycin 63.6 4 19864570 (1), 19520853 (1), 19472400 (1), 18760364 (1)
    c2ceramide 59.4 2 16390869 (1), 14970205 (1)
    hydroxychloroquine 39.4 2 19357706 (1), 19749781 (1)
    ceramide 32.4 7 19337026 (3), 19060920 (3), 20406981 (1)
    arsenite 23.6 2 19577553 (1), 16882451 (1)
    inositol 1,4,5 trisphosphate 20.2 1 19325567 (1)
    oxygen 14 5 18281291 (1), 19959713 (1), 19901551 (1), 16857678 (1) (see all 5)
    cholesterol 0 4 17611388 (2), 17468177 (1)

    Search CenterWatch for drugs/clinical trials and news about BECN1 

    Transcripts
    for BECN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BECN1 gene: 
    NM_003766.3  

    Unigene Cluster for BECN1:

    Beclin 1, autophagy related
    Hs.716464  [show with all ESTs]
    Unigene Representative Sequence: BX647788
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000361523(uc002ibo.3 uc010whc.1 uc002ibn.2) ENST00000590099
    ENST00000590764 ENST00000438274 ENST00000588276 ENST00000543382(uc010whb.1)
    ENST00000589663 ENST00000587880 ENST00000590185 ENST00000586589 ENST00000586754
    ENST00000589492 ENST00000590852 ENST00000593205 ENST00000589493 ENST00000591085
    ENST00000585515 ENST00000591307

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate BECN1 (see all 42):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-570 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmid: BECN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BECN1 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF077301.1 AF139131.1 AJ227885.1 AK130396.1 AK223411.1 AK298619.1 AK299616.1 AK312651.1 
    BC010276.1 BX647788.1 L38932.1 

    23 DOTS entries:

    DT.449520  DT.100815253  DT.95159054  DT.100815244  DT.97775540  DT.100028530  DT.121006745  DT.91854800 
    DT.95353996  DT.99943345  DT.121006686  DT.121006762  DT.92444400  DT.95159063  DT.97819965  DT.121006684 
    DT.121006740  DT.75163134  DT.95159052  DT.95159060  DT.97762417  DT.121006688  DT.95169537 

    24/355 AceView cDNA sequences (see all 355):

    CA406492 AL560004 BF437492 T27183 AL549639 AL040216 BP375347 AJ709876 
    BF971637 BM475727 AA856893 T35726 BM680710 CB124480 BI769074 N86468 
    BM456714 AA304571 AW949427 CK824845 AA574050 BG501425 BM839552 AA313474 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for BECN1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
    SP1:                          -           -     -           -     -     -     -                                         -                       -     -         
    SP2:              -           -           -     -           -     -     -     -                                                                                 
    SP3:                          -           -     -           -     -     -     -                                                                                 
    SP4:              -           -           -     -           -     -     -     -     -     -     -           -     -     -                                       
    SP5:                                                                                                                    -                       -     -     -   

    ExUns: 12a · 12b · 12c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for BECN1

    Expression
    for BECN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BECN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See BECN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BECN1

    SOURCE GeneReport for Unigene cluster: Hs.716464

    UniProtKB/Swiss-Prot: BECN1_HUMAN, Q14457
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including BECN1: 
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    Orthologs
    for BECN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BECN1 gene from 10/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Becn11 , 5 beclin 1, autophagy related1, 5 92.11(n)1
    98.44(a)1    		   11 (64.58 cM)5
    562081  NM_019584.31  NP_062530.21 
     1012859525 
    chicken
    (Gallus gallus)    		 Aves BECN11 beclin 1, autophagy related 79.12(n)
    92.39(a)    		   420018  NM_001006332.1  NP_001006332.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BECN16
    		 --
    		 91(a)
    		 1 ↔ 1
    		 6(62276348-62288141)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BQ737390.12   -- 81.36(n)    BQ737390.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC063319.12   -- 78.42(n)   393846  BC063319.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG54293
    Atg61    		 Autophagy-specific gene 61 50(a)3
    58.21(n)1
    53.17(a)1    		   95D103
    428501  NM_142952.21  NP_651209.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea bec-11 Protein BEC-1 43.97(n)
    31.27(a)    		   177345  NM_068443.2  NP_500844.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes VPS30(YPL120W)4
    VPS301    		 Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes more4
    Vps30p1    		 47.6(n)1
    35.17(a)1    		   16(322071-323744)4
    8559831, 4  NP_015205.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATG61 Beclin-1-like protein 44.67(n)
    34.26(a)    		   825344  NM_116036.3  NP_567116.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.248722 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.1(n)    AK101033.1 


    ENSEMBL Gene Tree for BECN1 (if available)
    TreeFam Gene Tree for BECN1 (if available) 

    Paralogs
    for BECN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BECN1 gene
    18/37 SIMAP similar genes for BECN1 using alignment to 13 protein entries:     BECN1_HUMAN (see all proteins) (see all similar genes):
    PLEKHH2    DNMT1    TCEB1    AURA2    ZNF564    HMGA2
    ZNF74    DCTN5    FKBP3    HKR1    NF2    LYRM4
    TMEM14B    BECN1P1    C4orf22    NEK4    SHANK2    APOD

    BECN1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BECN1
    PGOHUM00000245277 PGOHUM00000243666


    Genomic Variants
    for BECN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 NCBI SNPs in BECN1 are shown (see all 249)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1480604881,2
    		--40961720(+) TGGACA/GAGCAT 2 -- ds5001 ut310--------
    rs1909195991,2
    		--40962046(+) CTCTAA/CAGAAG 2 -- ut31 ds50010--------
    rs1813281641,2
    		--40962159(+) GTTTTC/TAGACT 2 -- ut310--------
    rs115521931,2
    		C,F,H--40962240(+) TATCTC/TTAACA 2 -- ut314Minor allele frequency- T:0.00NS NA 406
    rs1418112491,2
    		--40962304(+) AGCATC/GTGATC 2 -- ut310--------
    rs1863399981,2
    		--40962330(+) CAGGTA/GAAGCT 2 -- ut310--------
    rs802178481,2
    		--40962335(+) AAAGCC/TTAGAT 2 -- ut310--------
    rs1915902451,2
    		--40962418(+) TCATAC/TTGTTA 2 -- ut310--------
    rs1828677711,2
    		--40962432(+) GCAGGA/GAGTTG 2 -- ut310--------
    rs1403304921,2
    		--40962445(+) AGAGAG/TAAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for BECN1 (40962150 - 40985367 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BECN1: --

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    Disorders / Diseases
    for BECN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BECN1 for disorders           About GeneDecksing

    OMIM gene information: 604378    OMIM disorders: --

    20/51 diseases for BECN1 (see all 51):    About MalaCards
    machado-joseph disease    neurodegeneration    non-hodgkin lymphoma    squamous cell carcinoma
    esophageal squamous cell carcinoma    cervical squamous cell carcinoma    hodgkin's lymphoma    pancreatic ductal adenocarcinoma
    head injury    brain injury    cervix carcinoma    cystinosis
    epithelial ovarian cancer    malignant glioma    ovarian cancer    adenomyosis
    hepatocellular carcinoma    ptosis    colon cancer    carcinoma

    1 disease from the University of Copenhagen DISEASES database for BECN1:
    Cancer

    10/15 Novoseek disease relationships for BECN1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingolipidoses 57.3 4 17468177 (2), 17611388 (2)
    cancer 42.1 14 18184403 (2), 19060920 (2), 14657337 (1), 14638851 (1) (see all 8)
    tumors 39.7 52 20230646 (4), 14657337 (4), 11309306 (4), 16874027 (4) (see all 31)
    glioblastoma 26.2 3 19567133 (1), 19661320 (1), 19421400 (1)
    breast cancer 24.2 17 19762066 (5), 18829541 (2), 18184403 (1), 20230646 (1) (see all 9)
    glioma 18.1 3 20432283 (1), 19451193 (1), 19375507 (1), 19661320 (1)
    premalignant 15.9 1 14638851 (1)
    prostate cancer 14.6 2 20406981 (1), 10395800 (1)
    colon cancer 10.6 3 19066461 (2), 17595761 (1)
    ovarian cancer 10.4 3 11309306 (1), 17203225 (1), 10604474 (1)

    Human Genome Epidemiology (HuGE) Navigator: BECN1 (2 documents)

    Export disorders for BECN1 gene to outside databases

    Publications
    for BECN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BECN1 gene, integrated from 9 sources (see all 267):
    (articles sorted by number of sources associating them with BECN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. (PubMed id 9765397)1, 2, 3 Liang X.H.... Levine B. (1998)
    2. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. (PubMed id 10395800)1, 2, 9 Aita V.M.... Levine B. (1999)
    3. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. (PubMed id 19180116)1, 2, 9 Zalckvar E....Kimchi A. (2009)
    4. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. (PubMed id 17337444)1, 2, 9 Oberstein A.... Shi Y. (2007)
    5. Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin- 1. (PubMed id 17659302)1, 2, 9 Feng W.... Zhang M. (2007)
    6. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. (PubMed id 19050071)1, 2, 9 Sun Q....Zhong Q. (2008)
    7. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PubMed id 18843052)1, 2, 9 Itakura E....Mizushima N. (2008)
    8. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. (PubMed id 21962518)1, 2 Liu J....Yuan J. (2011)
    9. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (PubMed id 19270696)1, 2 Matsunaga K....Yoshimori T. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for BECN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BECN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8678 HGNC: 1034 AceView: BECN1 Ensembl:ENSG00000126581 euGenes: HUgn8678
    ECgene: BECN1 Kegg: 8678 H-InvDB: BECN1

    Other Databases showing BECN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BECN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BECN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BECN1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BECN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BECN1 gene:
    Search GeneIP for patents involving BECN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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