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Aliases for BECN1 Gene

Aliases for BECN1 Gene

  • Beclin 1, Autophagy Related 2 3
  • Coiled-Coil Myosin-Like BCL2-Interacting Protein 3 4
  • Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein) 2
  • Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein) 3
  • ATG6 Autophagy Related 6 Homolog (S. Cerevisiae) 2
  • ATG6 Autophagy Related 6 Homolog 3
  • Protein GT197 4
  • Beclin1 3
  • VPS30 3
  • GT197 4
  • ATG6 3

External Ids for BECN1 Gene

Previous GeneCards Identifiers for BECN1 Gene

  • GC17P040655
  • GC17M043124
  • GC17M040870
  • GC17M041335
  • GC17M038215
  • GC17M040963
  • GC17M036726

Summaries for BECN1 Gene

Entrez Gene Summary for BECN1 Gene

  • This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for BECN1 Gene

BECN1 (Beclin 1, Autophagy Related) is a Protein Coding gene. Diseases associated with BECN1 include pleomorphic adenoma carcinoma and breast cancer. Among its related pathways are Akt Signaling Pathway and Cellular Senescence. GO annotations related to this gene include sequence-specific DNA binding and phosphatidylinositol 3-kinase binding.

UniProtKB/Swiss-Prot for BECN1 Gene

  • Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

Gene Wiki entry for BECN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BECN1 Gene

Genomics for BECN1 Gene

Regulatory Elements for BECN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BECN1 Gene

Chromosome:
17
Start:
42,810,132 bp from pter
End:
42,833,350 bp from pter
Size:
23,219 bases
Orientation:
Minus strand

Genomic View for BECN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BECN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BECN1 Gene

Proteins for BECN1 Gene

  • Protein details for BECN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14457-BECN1_HUMAN
    Recommended name:
    Beclin-1
    Protein Accession:
    Q14457
    Secondary Accessions:
    • B2R6N7
    • O75595
    • Q9UNA8

    Protein attributes for BECN1 Gene

    Size:
    450 amino acids
    Molecular mass:
    51896 Da
    Quaternary structure:
    • Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex (PubMed:18843052, PubMed:19050071, PubMed:19270696, PubMed:23878393, PubMed:25490155). Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as KIAA0226/Rubicon, SH3GLB1/Bif-1 and AMBRA1 (PubMed:20643123, PubMed:19270696). PI3KC3-C1 probably associates with PIK3CB (By similarity). Interacts with AMBRA1, GOPC, GRID2 (By similarity). Interacts with BCL2 and BCL2L1 isoform Bcl-X(L); the interaction inhibits BECN1 function in promoting autophagy by interfering with the formation of the PI3K complex (PubMed:9765397, PubMed:16179260, PubMed:17446862, PubMed:17337444, PubMed:17659302). Interacts with cytosolic HMGB1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy (PubMed:20819940). Interacts with USP10, USP13, VMP1, DAPK1, RAB39A (PubMed:19180116, PubMed:17724469, PubMed:17337444, PubMed:21962518, PubMed:24349490). Interacts with SLAMF1 (PubMed:22493499). Interacts with human cytomegalovirus/HHV-5 protein TRS1 (PubMed:22205736). Interacts with TRIM5; the interaction causes activation of BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057).

    Three dimensional structures from OCA and Proteopedia for BECN1 Gene

neXtProt entry for BECN1 Gene

Proteomics data for BECN1 Gene at MOPED

Post-translational modifications for BECN1 Gene

  • Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy (PubMed:19180116). In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy (PubMed:23878393).
  • polyubiquitinated by NEDD4, both with Lys11- and Lys63-linkages. Lys-11-linked poyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes.
  • Ubiquitination at Lys 32
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for BECN1 (Beclin 1/ATG6)
  • Cell Signaling Technology (CST) Antibodies for BECN1 (beclin 1)

No data available for DME Specific Peptides for BECN1 Gene

Domains & Families for BECN1 Gene

Gene Families for BECN1 Gene

Protein Domains for BECN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BECN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14457

UniProtKB/Swiss-Prot:

BECN1_HUMAN :
  • Belongs to the beclin family.
Family:
  • Belongs to the beclin family.
genes like me logo Genes that share domains with BECN1: view

Function for BECN1 Gene

Molecular function for BECN1 Gene

GENATLAS Biochemistry:
beclin 1,myosin-like BCL2-interacting protein,potentially involved in antiviral host defense,deleted in breast cancer cell lines
UniProtKB/Swiss-Prot Function:
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

Gene Ontology (GO) - Molecular Function for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16417406
GO:0031625 ubiquitin protein ligase binding IPI 25127057
GO:0043548 phosphatidylinositol 3-kinase binding IPI 23878393
genes like me logo Genes that share ontologies with BECN1: view
genes like me logo Genes that share phenotypes with BECN1: view

Animal Models for BECN1 Gene

MGI Knock Outs for BECN1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BECN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BECN1 Gene

Localization for BECN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BECN1 Gene

Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome. Cytoplasmic vesicle, autophagosome. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250 UniProtKB:O88597, ECO:0000269 PubMed:19050071}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BECN1 Gene COMPARTMENTS Subcellular localization image for BECN1 gene
Compartment Confidence
endoplasmic reticulum 4
endosome 4
lysosome 3
mitochondrion 3
vacuole 3
cytosol 2
golgi apparatus 2
nucleus 2
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005737 cytoplasm --
GO:0005739 colocalizes_with mitochondrion IMP 23878393
GO:0005768 endosome IDA 23878393
GO:0005776 autophagosome IEA --
genes like me logo Genes that share ontologies with BECN1: view

Pathways & Interactions for BECN1 Gene

genes like me logo Genes that share pathways with BECN1: view

Pathways by source for BECN1 Gene

1 Cell Signaling Technology pathway for BECN1 Gene
1 BioSystems pathway for BECN1 Gene
2 Reactome pathways for BECN1 Gene

PCR Array Products

SIGNOR curated interactions for BECN1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly ISS --
GO:0000910 cytokinesis IMP 20208530
GO:0006914 autophagy IMP 24056303
GO:0006968 cellular defense response TAS 9765397
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with BECN1: view

Drugs & Compounds for BECN1 Gene

(6) Drugs for BECN1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxychloroquine Approved Pharma Autophagy inhibitor 128
3-Methyladenine Experimental Pharma Class III PI3K inhibitor, Class III PI 3-kinase inhibitor; also inhibits autophagy 0
cholesterol Experimental Pharma Agonist 0
Rapamycin Pharma mTOR inhibitor 0
serine Nutra 420

(7) Additional Compounds for BECN1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
C2ceramide
Ceramide
3102-57-6
inositol 1,4,5 trisphosphate
LIPID
genes like me logo Genes that share compounds with BECN1: view

Transcripts for BECN1 Gene

Unigene Clusters for BECN1 Gene

Beclin 1, autophagy related:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BECN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BECN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9:
SP10: - -
SP11: -
SP12:
SP13:

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for BECN1 Gene

GeneLoc Exon Structure for
BECN1
ECgene alternative splicing isoforms for
BECN1

Expression for BECN1 Gene

mRNA expression in normal human tissues for BECN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BECN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5) and Neutrophil (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BECN1 Gene



SOURCE GeneReport for Unigene cluster for BECN1 Gene Hs.716464

mRNA Expression by UniProt/SwissProt for BECN1 Gene

Q14457-BECN1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with BECN1: view

Protein tissue co-expression partners for BECN1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BECN1 Gene

Orthologs for BECN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BECN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BECN1 35
  • 94.79 (n)
  • 98.44 (a)
BECN1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BECN1 35
  • 94.94 (n)
  • 97.99 (a)
BECN1 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Becn1 35
  • 92.11 (n)
  • 98.44 (a)
Becn1 16
Becn1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BECN1 35
  • 99.78 (n)
  • 99.78 (a)
BECN1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Becn1 35
  • 92.49 (n)
  • 97.77 (a)
oppossum
(Monodelphis domestica)
Mammalia BECN1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BECN1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves BECN1 35
  • 79.12 (n)
  • 92.39 (a)
BECN1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BECN1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia becn1 35
  • 77.4 (n)
  • 88.96 (a)
Str.10355 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
becn1 35
  • 71.89 (n)
  • 79.19 (a)
becn1 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5429 37
  • 50 (a)
Atg6 35
  • 58.13 (n)
  • 53.17 (a)
Atg6 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003858 35
  • 59.02 (n)
  • 56.52 (a)
worm
(Caenorhabditis elegans)
Secernentea bec-1 35
  • 44.08 (n)
  • 32.23 (a)
bec-1 36
  • 29 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR154W 35
  • 47.45 (n)
  • 33.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01166g 35
  • 44.51 (n)
  • 31.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS30 35
  • 47.02 (n)
  • 35.11 (a)
VPS30 36
  • 21 (a)
OneToOne
VPS30 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG6 35
  • 44.84 (n)
  • 34.26 (a)
rice
(Oryza sativa)
Liliopsida Os.24872 35
Os01g0681400 35
  • 51.68 (n)
  • 38.44 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2772 35
corn
(Zea mays)
Liliopsida Zm.12996 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03122 35
  • 49.25 (n)
  • 36.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atg6 35
  • 44.87 (n)
  • 32.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2825 36
  • 55 (a)
OneToOne
Species with no ortholog for BECN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BECN1 Gene

ENSEMBL:
Gene Tree for BECN1 (if available)
TreeFam:
Gene Tree for BECN1 (if available)

Paralogs for BECN1 Gene

Pseudogenes.org Pseudogenes for BECN1 Gene

genes like me logo Genes that share paralogs with BECN1: view

No data available for Paralogs for BECN1 Gene

Variants for BECN1 Gene

Sequence variations from dbSNP and Humsavar for BECN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs751540 -- 42,817,680(-) gtagt(A/C)ctagc intron-variant
rs1079394 -- 42,819,926(-) ATTTA(A/G)GGCAT intron-variant
rs1399050 -- 42,816,182(-) GATCT(A/G)TGCCA intron-variant
rs2290039 -- 42,814,358(+) GGAGA(C/G)AGCCC intron-variant
rs3043208 -- 42,819,898(+) CACTT(-/AGC)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BECN1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv833450 CNV Loss 17160897

Variation tolerance for BECN1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BECN1 Gene

HapMap Linkage Disequilibrium report
BECN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BECN1 Gene

Disorders for BECN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BECN1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
pleomorphic adenoma carcinoma
  • carcinoma ex pleomorphic adenoma
breast cancer
  • breast cancer, invasive ductal
- elite association
Search BECN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BECN1

Genetic Association Database (GAD)
BECN1
Human Genome Epidemiology (HuGE) Navigator
BECN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BECN1
genes like me logo Genes that share disorders with BECN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BECN1 Gene

Publications for BECN1 Gene

  1. Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer. (PMID: 19762066) Won K.Y. … Lim S.J. (Hum. Pathol. 2010) 23 67
  2. Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. (PMID: 20101204) Djavaheri-Mergny M. … Kroemer G. (Oncogene 2010) 23 67
  3. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. (PMID: 19713971) Luo S. … Rubinsztein D.C. (Cell Death Differ. 2010) 23 67
  4. Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions. (PMID: 20004946) Miracco C. … Massi D. (Hum. Pathol. 2010) 23 67
  5. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. (PMID: 20010695) Chang N.C. … Shore G.C. (EMBO J. 2010) 23 67

Products for BECN1 Gene

Sources for BECN1 Gene

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