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Aliases for BECN1 Gene

Aliases for BECN1 Gene

  • Beclin 1, Autophagy Related 2 3
  • Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein) 2 3
  • Coiled-Coil Myosin-Like BCL2-Interacting Protein 3 4
  • Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein) 3
  • ATG6 Autophagy Related 6 Homolog (S. Cerevisiae) 2
  • ATG6 Autophagy Related 6 Homolog 3
  • Protein GT197 4
  • Beclin-1 3
  • Beclin1 3
  • VPS30 3
  • GT197 4
  • ATG6 3

External Ids for BECN1 Gene

Previous GeneCards Identifiers for BECN1 Gene

  • GC17P040655
  • GC17M043124
  • GC17M040870
  • GC17M041335
  • GC17M038215
  • GC17M040963
  • GC17M036726

Summaries for BECN1 Gene

Entrez Gene Summary for BECN1 Gene

  • Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]

GeneCards Summary for BECN1 Gene

BECN1 (Beclin 1, Autophagy Related) is a Protein Coding gene. Diseases associated with BECN1 include hepatocellular carcinoma. Among its related pathways are Akt Signaling Pathway and Apoptosis and Autophagy.

UniProtKB/Swiss-Prot for BECN1 Gene

  • Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

Gene Wiki entry for BECN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BECN1 Gene

Genomics for BECN1 Gene

Regulatory Elements for BECN1 Gene

Genomic Location for BECN1 Gene

Start:
42,810,132 bp from pter
End:
42,833,350 bp from pter
Size:
23,219 bases
Orientation:
Minus strand

Genomic View for BECN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BECN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BECN1 Gene

Proteins for BECN1 Gene

  • Protein details for BECN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14457-BECN1_HUMAN
    Recommended name:
    Beclin-1
    Protein Accession:
    Q14457
    Secondary Accessions:
    • B2R6N7
    • O75595
    • Q9UNA8

    Protein attributes for BECN1 Gene

    Size:
    450 amino acids
    Molecular mass:
    51896 Da
    Quaternary structure:
    • Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy (By similarity). Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB (By similarity). Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1.

    Three dimensional structures from OCA and Proteopedia for BECN1 Gene

neXtProt entry for BECN1 Gene

Proteomics data for BECN1 Gene at MOPED

Post-translational modifications for BECN1 Gene

  • Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy (PubMed:19180116). In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy (PubMed:23878393).
  • polyubiquitinated by NEDD4, both with Lys11- and Lys63-linkages. Lys-11-linked poyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes.
  • Ubiquitination at Lys32
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BECN1 Gene

Domains for BECN1 Gene

Protein Domains for BECN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BECN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14457

UniProtKB/Swiss-Prot:

BECN1_HUMAN :
  • Q14457
Family:
  • Belongs to the beclin family.
genes like me logo Genes that share domains with BECN1: view

No data available for Gene Families for BECN1 Gene

Function for BECN1 Gene

Molecular function for BECN1 Gene

GENATLAS Biochemistry: beclin 1,myosin-like BCL2-interacting protein,potentially involved in antiviral host defense,deleted in breast cancer cell lines
UniProtKB/Swiss-Prot Function: Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

Gene Ontology (GO) - Molecular Function for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16417406
GO:0043548 phosphatidylinositol 3-kinase binding IPI 23878393
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with BECN1: view
genes like me logo Genes that share phenotypes with BECN1: view

Animal Models for BECN1 Gene

MGI Knock Outs for BECN1:

miRNA for BECN1 Gene

miRTarBase miRNAs that target BECN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BECN1 Gene

Localization for BECN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BECN1 Gene

Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250 UniProtKB:O88597, ECO:0000269 PubMed:19050071}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BECN1 Gene COMPARTMENTS Subcellular localization image for BECN1 gene
Compartment Confidence
vacuole 4
golgi apparatus 3
lysosome 3
cytosol 2
endoplasmic reticulum 2
endosome 2
mitochondrion 2
nucleus 2
cytoskeleton 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005739 colocalizes_with mitochondrion IMP 23878393
GO:0005768 endosome IDA 23878393
genes like me logo Genes that share ontologies with BECN1: view

Pathways for BECN1 Gene

genes like me logo Genes that share pathways with BECN1: view

Pathways by source for BECN1 Gene

1 Cell Signaling Technology pathway for BECN1 Gene
1 BioSystems pathway for BECN1 Gene
1 KEGG pathway for BECN1 Gene

Gene Ontology (GO) - Biological Process for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly ISS --
GO:0000910 cytokinesis IMP 20208530
GO:0001666 response to hypoxia IEA --
GO:0006914 autophagy IMP 24056303
GO:0006968 cellular defense response TAS 9765397
genes like me logo Genes that share ontologies with BECN1: view

Compounds for BECN1 Gene

(13) Novoseek inferred chemical compound relationships for BECN1 Gene

Compound -log(P) Hits PubMed IDs
3-methyladenine 92 7
monodansylcadaverine 73.6 1
rapamycin 63.6 4
c2ceramide 59.4 2
hydroxychloroquine 39.4 2
genes like me logo Genes that share compounds with BECN1: view

Transcripts for BECN1 Gene

Unigene Clusters for BECN1 Gene

Beclin 1, autophagy related:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BECN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9:
SP10: - -
SP11: -
SP12:
SP13:

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for BECN1 Gene

GeneLoc Exon Structure for
BECN1
ECgene alternative splicing isoforms for
BECN1

Expression for BECN1 Gene

mRNA expression in normal human tissues for BECN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BECN1 Gene

SOURCE GeneReport for Unigene cluster for BECN1 Gene Hs.716464

mRNA Expression by UniProt/SwissProt for BECN1 Gene

Q14457-BECN1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with BECN1: view

No data available for mRNA differential expression in normal tissues for BECN1 Gene

Orthologs for BECN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BECN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BECN1 35
  • 99.78 (n)
  • 99.78 (a)
BECN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BECN1 35
  • 94.79 (n)
  • 98.44 (a)
BECN1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BECN1 35
  • 94.94 (n)
  • 97.99 (a)
BECN1 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Becn1 35
  • 92.11 (n)
  • 98.44 (a)
Becn1 16
Becn1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BECN1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BECN1 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Becn1 35
  • 92.49 (n)
  • 97.77 (a)
chicken
(Gallus gallus)
Aves BECN1 35
  • 79.12 (n)
  • 92.39 (a)
BECN1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BECN1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia becn1 35
  • 77.4 (n)
  • 88.96 (a)
Str.10355 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
becn1 35
  • 71.89 (n)
  • 79.19 (a)
becn1 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003858 35
  • 59.02 (n)
  • 56.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg6 35
  • 58.13 (n)
  • 53.17 (a)
Atg6 36
  • 52 (a)
OneToOne
CG5429 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea bec-1 35
  • 44.08 (n)
  • 32.23 (a)
bec-1 36
  • 29 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR154W 35
  • 47.45 (n)
  • 33.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS30 35
  • 47.02 (n)
  • 35.11 (a)
VPS30 36
  • 21 (a)
OneToOne
VPS30 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01166g 35
  • 44.51 (n)
  • 31.97 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG6 35
  • 44.84 (n)
  • 34.26 (a)
corn
(Zea mays)
Liliopsida Zm.12996 35
rice
(Oryza sativa)
Liliopsida Os.24872 35
Os01g0681400 35
  • 51.68 (n)
  • 38.44 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2772 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03122 35
  • 49.25 (n)
  • 36.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atg6 35
  • 44.87 (n)
  • 32.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2825 36
  • 55 (a)
OneToOne
Species with no ortholog for BECN1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BECN1 Gene

ENSEMBL:
Gene Tree for BECN1 (if available)
TreeFam:
Gene Tree for BECN1 (if available)

Paralogs for BECN1 Gene

Pseudogenes.org Pseudogenes for BECN1 Gene

genes like me logo Genes that share paralogs with BECN1: view

No data available for Paralogs for BECN1 Gene

Variants for BECN1 Gene

Sequence variations from dbSNP and Humsavar for BECN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs751540 -- 42,817,680(-) gtagt(A/C)ctagc intron-variant
rs1079394 -- 42,819,926(-) ATTTA(A/G)GGCAT intron-variant
rs1399050 -- 42,816,182(-) GATCT(A/G)TGCCA intron-variant
rs2290039 -- 42,814,358(+) GGAGA(C/G)AGCCC intron-variant
rs3043208 -- 42,819,898(+) CACTT(-/AGC)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BECN1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv833450 CNV Loss 17160897

Relevant External Links for BECN1 Gene

HapMap Linkage Disequilibrium report
BECN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BECN1 Gene

Disorders for BECN1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BECN1 Gene including...

Search for BECN1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BECN1 Gene

(15) Novoseek inferred disease relationships for BECN1 Gene

Disease -log(P) Hits PubMed IDs
sphingolipidoses 57.3 4
cancer 42.1 10
tumors 39.7 46
glioblastoma 26.2 3
breast cancer 24.2 14

Relevant External Links for BECN1

Genetic Association Database (GAD)
BECN1
Human Genome Epidemiology (HuGE) Navigator
BECN1
genes like me logo Genes that share disorders with BECN1: view

No data available for UniProtKB/Swiss-Prot for BECN1 Gene

Publications for BECN1 Gene

  1. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. (PMID: 10395800) Aita V.M. … Levine B. (Genomics 1999) 3 4 23
  2. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. (PMID: 17337444) Oberstein A. … Shi Y. (J. Biol. Chem. 2007) 3 4 23
  3. Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin- 1. (PMID: 17659302) Feng W. … Zhang M. (J. Mol. Biol. 2007) 3 4 23
  4. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PMID: 18843052) Itakura E. … Mizushima N. (Mol. Biol. Cell 2008) 3 4 23
  5. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. (PMID: 19050071) Sun Q. … Zhong Q. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 23

Products for BECN1 Gene

  • Addgene plasmids for BECN1

Sources for BECN1 Gene

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