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BEAN1 Gene

protein-coding   GIFtS: 38
GCID: GC16P066460

Brain Expressed, Associated With NEDD4, 1

(Previous name: spinocerebellar ataxia 31)
(Previous symbol: SCA31)
  See BEAN1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Brain Expressed, Associated With NEDD4, 11 2
SCA311 2 5
BEAN2 3 5
Brain-Expressed Protein Associating With Nedd4 Homolog2 3
Spinocerebellar Ataxia 311
Protein BEAN12

External Ids:    HGNC: 241601   Entrez Gene: 1462272   Ensembl: ENSG000001665467   OMIM: 6120515   UniProtKB: Q3B7T33   

Export aliases for BEAN1 gene to outside databases

Previous GC identifer: GC16P052336


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BEAN1 Gene:
The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of
ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is
developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic
insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with
spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for BEAN1 Gene:
BEAN1 (brain expressed, associated with NEDD4, 1) is a protein-coding gene. Diseases associated with BEAN1 include spinocerebellar ataxia 31, and ataxia.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for BEAN1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for BEAN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BEAN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

BEAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BEAN1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066460:  view genomic region     (about GC identifiers)

Start:
66,460,816 bp from pter      End:
66,527,432 bp from pter
Size:
66,617 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BEAN1_HUMAN, Q3B7T3 (See protein sequence)
Recommended Name: Protein BEAN1  
Size: 259 amino acids; 28626 Da
Subunit: Interacts with NEDD4 (By similarity)
Sequence caution: Sequence=AAI07478.1; Type=Erroneous initiation; Sequence=EG328447; Type=Frameshift;
Positions=79;
Secondary accessions: B3KPC0 H3BP97
Alternative splicing: 3 isoforms:  Q3B7T3-1   Q3B7T3-2   Q3B7T3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BEAN1: NX_Q3B7T3

REFSEQ proteins (4 alternative transcripts): 
NP_001129578.1  NP_001171491.1  NP_001184153.1  NP_001184154.1  

ENSEMBL proteins: 
 ENSP00000442793   ENSP00000456822   ENSP00000299694   ENSP00000455212   ENSP00000456430  
 ENSP00000462088  

BEAN1 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for BEAN1
OriGene Custom MassSpec
OriGene Custom Protein Services for BEAN1
GenScript Custom Purified and Recombinant Proteins Services for BEAN1
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for BEAN1 

 
Search antibodies-online for proteins for BEAN1 

 
antibodies-online peptides for BEAN1

BEAN1 Antibody Products:

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OriGene Custom Antibody Services for BEAN1
Novus Biologicals BEAN1 Antibody
Abcam antibodies for BEAN1
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for BEAN1
LSBio Antibodies in human, mouse, rat for BEAN1
antibodies-online antibodies for BEAN1 (23 products) 

BEAN1 Assay Products:

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GenScript Custom Assay Services for BEAN1
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for BEAN1 
antibodies-online kits for BEAN1 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q3B7T3


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with BEAN1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for BEAN1:
 Decreased viability with pacli 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BEAN1
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BEAN1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BEAN1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat BEAN1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate BEAN1 (see all 38):
hsa-miR-3678-3p hsa-miR-765 hsa-miR-29a hsa-miR-30d hsa-miR-570 hsa-miR-30a hsa-miR-298 hsa-miR-3163
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for BEAN1
Predesigned siRNA for gene silencing in human, mouse, rat BEAN1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for BEAN1

Clone
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OriGene clones in human, mouse for BEAN1 (see all 21)
OriGene ORF clones in mouse, rat for BEAN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): BEAN1 (NM_001197224)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEAN1
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BEAN1

Cell Line
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GenScript Custom overexpressing Cell Line Services for BEAN1
Browse ESI BIO Cell Lines and PureStem Progenitors for BEAN1 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEAN1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
BEAN1_HUMAN, Q3B7T3: Membrane; Single-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with BEAN1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BEAN1
Interactions:

    Search GeneGlobe Interaction Network for BEAN1

1 Interacting protein for BEAN1 (Q3B7T33) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
NEDD4P469343I2D: score=2 
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008219cell death IEA--

Find genes that share ontologies with BEAN1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for BEAN1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for BEAN1 gene (4 alternative transcripts): 
NM_001136106.4  NM_001178020.2  NM_001197224.2  NM_001197225.2  

Unigene Cluster for BEAN1:

Brain expressed, associated with NEDD4, 1
Hs.97805  [show with all ESTs]
Unigene Representative Sequence: AK130753
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000536005 ENST00000562849(uc002eop.2 uc021tjl.1 uc002eoq.3)
ENST00000299694 ENST00000561796(uc021tjm.1 uc021tjn.1 uc021tjo.1 uc021tjq.1)
ENST00000569272 ENST00000564819 ENST00000563075 ENST00000562146 ENST00000566654

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat BEAN1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate BEAN1 (see all 38):
hsa-miR-3678-3p hsa-miR-765 hsa-miR-29a hsa-miR-30d hsa-miR-570 hsa-miR-30a hsa-miR-298 hsa-miR-3163
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for BEAN1
Predesigned siRNA for gene silencing in human, mouse, rat BEAN1
Clone
Products:
     
OriGene clones in human, mouse for BEAN1 (see all 21)
OriGene ORF clones in mouse, rat for BEAN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): BEAN1 (NM_001197224)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for BEAN1
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BEAN1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for BEAN1
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BEAN1
  QuantiTect SYBR Green Assays in human, mouse, rat BEAN1
  QuantiFast Probe-based Assays in human, mouse, rat BEAN1

Additional mRNA sequence: 

AB472390.1 AB472391.1 AB472392.1 AB472393.1 AB472394.1 AB472396.1 AB472399.1 AF070610.1 
AK130753.1 BC000818.1 BC105723.1 BC105724.1 BC107477.1 

6 DOTS entries:

DT.313160  DT.102830498  DT.102819801  DT.403209  DT.120724929  DT.91823895 

Selected AceView cDNA sequences (see all 31):

AI698834 BX106363 AK056142 AF070610 BM666201 BC000818 BE537773 AW294004 
AA043142 BM711220 AI056905 AA351583 AI025464 CB265688 AA351584 AA040867 
H17282 AA035444 BI915496 AW005260 AA040873 CK023750 AA035584 AA043136 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BEAN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACACCCTTC
BEAN1 Expression
About this image

BEAN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.97805
    Custom PCR Arrays for BEAN1
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for BEAN1
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BEAN1
QuantiTect SYBR Green Assays in human, mouse, rat BEAN1
QuantiFast Probe-based Assays in human, mouse, rat BEAN1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEAN1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for BEAN1 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Bean11 , 5 brain expressed, associated with Nedd4, 11, 5 80.62(n)1
80.23(a)1
  8 (53.04 cM)5
651151  NM_001141922.11  NP_001135394.11 
 1041705135 
chicken
(Gallus gallus)
Aves BEAN16
Gallus gallus brain expressed, associated with NED...
36(a)
1 ↔ 1
11(10927995-10964663)
zebrafish
(Danio rerio)
Actinopterygii BEAN16
brain expressed, associated with NEDD4, 1
29(a)
1 ↔ 1
7(45472800-45568430) ENSDARG00000087413


ENSEMBL Gene Tree for BEAN1 (if available)
TreeFam Gene Tree for BEAN1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for BEAN1 gene
Selected SIMAP similar genes for BEAN1 using alignment to 3 protein entries:     BEAN1_HUMAN (see all proteins) (see all similar genes):
ATF1    IRF2    GALK2    EEF1E1    ABI2    EIF3G
LSM12    PTPN22    ZNF114    ARIH1    EIF3K    PFKFB3
C12orf76    TUBA1C    VPS33A    CDK10    NUP93    ZNF180

Find genes that share paralogs with BEAN1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for BEAN1 (see all 1073)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1843251801,2
--52335071(+) CAGTCC/TGAGGA 4 -- int10--------
rs1899963251,2
--52335189(+) CACTTA/GTCCCT 2 -- us2k10--------
rs1491604501,2
--52335216(+) CCACA-/ACACACA 2 -- us2k10--------
rs1811218901,2
--52335305(+) GGAAGA/GGTCAG 2 -- us2k10--------
rs1845424451,2
--52335616(+) AATAGC/TGCAGG 2 -- us2k10--------
rs129198861,2
C,F--52335664(+) GGGAGA/GTGTCC 2 -- us2k19Minor allele frequency- G:0.28NA WA CSA 252
rs1462645481,2
--52335731(+) AAGACA/GTGATG 2 -- us2k10--------
rs342856781,2
C--52335893(+) CACCAT/CGCTTT 2 -- us2k15Minor allele frequency- C:0.21NA WA EA 362
rs1889567341,2
C--52335899(+) GCTTTA/TTTTTT 2 -- us2k10--------
rs1143521791,2
C,F--52336087(+) CCCCTG/ACAGCC 2 -- us2k11Minor allele frequency- A:0.08WA 118

HapMap Linkage Disequilibrium report for BEAN1 (66460816 - 66527432 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for BEAN1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2672892CNV Deletion23128226
esv2714644CNV Deletion23290073
esv2661454CNV Deletion23128226
nsv1838CNV Insertion18451855
nsv906786CNV Loss21882294
nsv906785CNV Loss21882294
nsv827705CNV Gain20364138
nsv833264CNV Gain17160897

Human Gene Mutation Database (HGMD): BEAN1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing BEAN1
DNA2.0 Custom Variant and Variant Library Synthesis for BEAN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612051   
OMIM disorders: 117210  
UniProtKB/Swiss-Prot: BEAN1_HUMAN, Q3B7T3
  • Spinocerebellar ataxia 31 (SCA31) [MIM:117210]: A form of spinocerebellar ataxia, a clinically and
    genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and
    often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable
    involvement of the brainstem and spinal cord. SCA31 belongs to the autosomal dominant cerebellar ataxias type III
    (ADCA III) which are characterized by pure cerebellar ataxia without additional signs. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 2 diseases for BEAN1:    
    About MalaCards
    spinocerebellar ataxia 31    ataxia


    Find genes that share disorders with BEAN1           About GenesLikeMe


    Export disorders for BEAN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BEAN1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with BEAN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)n in the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis. (PubMed id 23607545)1, 3 Niimi Y....Ishikawa K. (Neuropathology 2013)
    2. Spinocerebellar ataxia type 31 is associated with 'inserted' penta- nucleotide repeats containing (TGGAA)n. (PubMed id 19878914)1, 2 Sato N.... Mizusawa H. (Am. J. Hum. Genet. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. (PubMed id 11042109)1, 3 Jolliffe C.N....Kumar S. (Biochem. J. 2000)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    6. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    7. SCA31 is rare in the Chinese population on Taiwan. (PubMed id 21163552)1 Lee Y.C....Soong B.W. (Neurobiol. Aging 2012)
    8. Pentanucleotide repeats at the spinocerebellar ataxia type 31 (SCA31) locus in Caucasians. (PubMed id 22049201)1 Ishikawa K....Mizusawa H. (Neurology 2011)
    9. Autosomal dominant cerebellar ataxias: polyglutamine expansions and beyond. (PubMed id 20723845)1 Durr A. (Lancet Neurol 2010)
    10. [Spinocerebellar ataxia type 31]. (PubMed id 21921537)1 Ishikawa K....Mizusawa H. (Rinsho Shinkeigaku 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146227 HGNC: 24160 AceView: BEAN Ensembl:ENSG00000166546 euGenes: HUgn146227
    ECgene: BEAN1 H-InvDB: BEAN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BEAN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BEAN1 gene:
    Search GeneIP for patents involving BEAN1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BEAN1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for BEAN1  
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     Block miRNA regulation of human, mouse, rat BEAN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BEAN1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BEAN1 Predesigned siRNA for gene silencing in human, mouse, rat BEAN1
     QuantiFast Probe-based Assays in human, mouse, rat BEAN1 QuantiTect SYBR Green Assays in human, mouse, rat BEAN1
     Custom PCR Arrays for BEAN1 Search Chromatin IP Primers for BEAN1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BEAN1  Search GeneGlobe Interaction Network for BEAN1
     Search Regulatory tfbs for BEAN1
     GenScript Custom Purified and Recombinant Proteins Services for BEAN1 GenScript cDNA clones with any tag delivered in your preferred vector for BEAN1
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     Search Tocris compounds for BEAN1
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     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
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     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for BEAN1
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BEAN1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for BEAN1
     Browse SwitchGear Promoter luciferase reporter plasmids for BEAN1
     Search ThermoFisher Antibodies for BEAN1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BEAN1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BEAN1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BEAN1
     LSBio Antibodies in human, mouse, rat for BEAN1
     Browse compounds at ApexBio
     Search Addgene for plasmids for BEAN1
      Search eBioscience for proteins for BEAN1
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      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
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     antibodies-online antibodies for BEAN1 (23 products)
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      Search antibodies-online for proteins for BEAN1
           
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