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Aliases for BEAN1 Gene

Aliases for BEAN1 Gene

  • Brain Expressed, Associated With NEDD4, 1 2 3
  • Brain-Expressed Protein Associating With Nedd4 Homolog 3 4
  • BEAN 3 4
  • Spinocerebellar Ataxia 31 2
  • SCA31 3

External Ids for BEAN1 Gene

Previous HGNC Symbols for BEAN1 Gene

  • SCA31

Previous GeneCards Identifiers for BEAN1 Gene

  • GC16P052336

Summaries for BEAN1 Gene

Entrez Gene Summary for BEAN1 Gene

  • The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for BEAN1 Gene

BEAN1 (Brain Expressed, Associated With NEDD4, 1) is a Protein Coding gene. Diseases associated with BEAN1 include spinocerebellar ataxia 31 and spinocerebellar degeneration.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEAN1 Gene

Genomics for BEAN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BEAN1 Gene

66,427,297 bp from pter
66,493,529 bp from pter
66,233 bases
Plus strand

Genomic View for BEAN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BEAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEAN1 Gene

No data available for Regulatory Elements for BEAN1 Gene

Proteins for BEAN1 Gene

  • Protein details for BEAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BEAN1
    Protein Accession:
    Secondary Accessions:
    • B3KPC0
    • H3BP97

    Protein attributes for BEAN1 Gene

    259 amino acids
    Molecular mass:
    28626 Da
    Quaternary structure:
    • Interacts with NEDD4.
    • Sequence=AAI07478.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EG328447; Type=Frameshift; Positions=79; Evidence={ECO:0000305};

    Alternative splice isoforms for BEAN1 Gene


neXtProt entry for BEAN1 Gene

Proteomics data for BEAN1 Gene at MOPED

Post-translational modifications for BEAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BEAN1 Gene

Domains & Families for BEAN1 Gene

Protein Domains for BEAN1 Gene


Suggested Antigen Peptide Sequences for BEAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BEAN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BEAN1 Gene

Function for BEAN1 Gene

Gene Ontology (GO) - Molecular Function for BEAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BEAN1: view

Phenotypes for BEAN1 Gene

genes like me logo Genes that share phenotypes with BEAN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BEAN1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BEAN1 Gene

Localization for BEAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEAN1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BEAN1 Gene COMPARTMENTS Subcellular localization image for BEAN1 gene
Compartment Confidence
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BEAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BEAN1: view

Pathways & Interactions for BEAN1 Gene

SuperPathways for BEAN1 Gene

No Data Available

Interacting Proteins for BEAN1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000442793 Q3B7T3-BEAN1_HUMAN for BEAN1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BEAN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for BEAN1 Gene

Drugs & Compounds for BEAN1 Gene

No Compound Related Data Available

Transcripts for BEAN1 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BEAN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEAN1 Gene

No ASD Table

Relevant External Links for BEAN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEAN1 Gene

mRNA expression in normal human tissues for BEAN1 Gene

mRNA differential expression in normal tissues according to GTEx for BEAN1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.2).

SOURCE GeneReport for Unigene cluster for BEAN1 Gene Hs.97805

genes like me logo Genes that share expression patterns with BEAN1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BEAN1 Gene

Orthologs for BEAN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEAN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BEAN1 35
  • 85.1 (n)
  • 85.1 (a)
BEAN1 36
  • 72 (a)
(Canis familiaris)
Mammalia BEAN1 35
  • 84.57 (n)
  • 84.05 (a)
BEAN1 36
  • 84 (a)
(Mus musculus)
Mammalia Bean1 35
  • 80.62 (n)
  • 80.23 (a)
Bean1 16
Bean1 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Bean1 35
  • 82.82 (n)
  • 81.4 (a)
(Pan troglodytes)
Mammalia BEAN1 36
  • 98 (a)
(Gallus gallus)
Aves BEAN1 36
  • 36 (a)
(Danio rerio)
Actinopterygii BEAN1 36
  • 29 (a)
Species with no ortholog for BEAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEAN1 Gene

Gene Tree for BEAN1 (if available)
Gene Tree for BEAN1 (if available)

Paralogs for BEAN1 Gene

genes like me logo Genes that share paralogs with BEAN1: view

No data available for Paralogs for BEAN1 Gene

Variants for BEAN1 Gene

Sequence variations from dbSNP and Humsavar for BEAN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs37166 -- 66,481,217(+) CTCCC(A/G)GCCTG utr-variant-3-prime, intron-variant
rs37167 -- 66,490,848(+) TCAGC(C/T)TTTCA intron-variant
rs40191 -- 66,483,423(+) CTACA(C/T)GTTTT intron-variant
rs94163 -- 66,478,921(-) GTGCT(C/T)GCCTG intron-variant, downstream-variant-500B
rs749345 -- 66,478,906(-) TGGGC(C/T)TTTGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BEAN1 Gene

Variant ID Type Subtype PubMed ID
nsv833264 CNV Gain 17160897
nsv906785 CNV Loss 21882294
nsv1838 CNV Insertion 18451855
nsv827705 CNV Gain 20364138
nsv906786 CNV Loss 21882294
esv2661454 CNV Deletion 23128226
esv2714644 CNV Deletion 23290073
esv2672892 CNV Deletion 23128226

Variation tolerance for BEAN1 Gene

Gene Damage Index Score: 1.91; 35.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BEAN1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEAN1 Gene

Disorders for BEAN1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for BEAN1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 31
  • sca31
spinocerebellar degeneration
  • spinocerebellar degenerations
spinocerebellar ataxia
  • cardiac arrest
- elite association
Search BEAN1 in MalaCards View complete list of genes associated with diseases


  • Spinocerebellar ataxia 31 (SCA31) [MIM:117210]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA31 belongs to the autosomal dominant cerebellar ataxias type III (ADCA III) which are characterized by pure cerebellar ataxia without additional signs. {ECO:0000269 PubMed:19878914}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for BEAN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BEAN1: view

No data available for Genatlas for BEAN1 Gene

Publications for BEAN1 Gene

  1. Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)n in the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis. (PMID: 23607545) Niimi Y. … Ishikawa K. (Neuropathology 2013) 2 67
  2. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. (PMID: 11042109) Jolliffe C.N. … Kumar S. (Biochem. J. 2000) 2 67
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 67
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 67
  5. SCA31 is rare in the Chinese population on Taiwan. (PMID: 21163552) Lee Y.C. … Soong B.W. (Neurobiol. Aging 2012) 67

Products for BEAN1 Gene

Sources for BEAN1 Gene

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