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Aliases for BDP1 Gene

Aliases for BDP1 Gene

  • B Double Prime 1, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB 2 3
  • TFNR 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase III, GTF3B Subunit 1 2 3
  • Transcription Factor-Like Nuclear Regulator 3 4
  • Transcription Factor IIIB 150 3 4
  • TFIIIB150 3 4
  • RNA Polymerase III Transcription Initiation Factor B 3
  • Transcription Factor TFIIIB Component B Homolog 3
  • HSA238520 3
  • TFIIIB90 3
  • KIAA1241 4
  • KIAA1689 4
  • TFIIIB 3
  • TAF3B1 3
  • TFC5 3

External Ids for BDP1 Gene

Previous Symbols for BDP1 Gene

  • TFNR
  • TAF3B1

Summaries for BDP1 Gene

Entrez Gene Summary for BDP1 Gene

  • The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for BDP1 Gene

BDP1 (B Double Prime 1, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for BDP1 Gene

  • General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.

Gene Wiki entry for BDP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDP1 Gene

Genomics for BDP1 Gene

Genomic Location for BDP1 Gene

Start:
71,455,615 bp from pter
End:
71,567,822 bp from pter
Size:
112,208 bases
Orientation:
Plus strand

Genomic View for BDP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDP1 Gene

Regulatory Elements for BDP1 Gene

Proteins for BDP1 Gene

  • Protein details for BDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6H8Y1-BDP1_HUMAN
    Recommended name:
    Transcription factor TFIIIB component B homolog
    Protein Accession:
    A6H8Y1
    Secondary Accessions:
    • Q68DS6
    • Q68DY5
    • Q6MZL9
    • Q6PIM7
    • Q86W98
    • Q96LR8
    • Q9C0H4
    • Q9H197
    • Q9H1A1
    • Q9HAW1
    • Q9HAW2
    • Q9HCY0
    • Q9ULH9

    Protein attributes for BDP1 Gene

    Size:
    2624 amino acids
    Molecular mass:
    293885 Da
    Quaternary structure:
    • Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the classical pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43.
    SequenceCaution:
    • Sequence=AAG09268.1; Type=Frameshift; Positions=837, 863; Evidence={ECO:0000305}; Sequence=AAH32146.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86555.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21780.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18085.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BDP1 Gene

neXtProt entry for BDP1 Gene

Proteomics data for BDP1 Gene at MOPED

Post-translational modifications for BDP1 Gene

  • Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BDP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for BDP1 Gene

Domains for BDP1 Gene

Protein Domains for BDP1 Gene

UniProtKB/Swiss-Prot:

BDP1_HUMAN
Domain:
  • Contains 1 Myb-like domain.:
    • A6H8Y1
genes like me logo Genes that share domains with BDP1: view

No data available for Gene Families for BDP1 Gene

Function for BDP1 Gene

Molecular function for BDP1 Gene

UniProtKB/Swiss-Prot Function: General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.
UniProtKB/Swiss-Prot Induction: By Epstein-Barr virus (EBV) resulting in the stimulation of the EBV EBER genes.

Gene Ontology (GO) - Molecular Function for BDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with BDP1: view
genes like me logo Genes that share phenotypes with BDP1: view

miRNA for BDP1 Gene

miRTarBase miRNAs that target BDP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BDP1 Gene

Localization for BDP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BDP1 Gene COMPARTMENTS Subcellular localization image for BDP1 gene
Compartment Confidence
nucleus 5
endosome 1

Gene Ontology (GO) - Cellular Components for BDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BDP1: view

Pathways for BDP1 Gene

genes like me logo Genes that share pathways with BDP1: view

Gene Ontology (GO) - Biological Process for BDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with BDP1: view

Transcripts for BDP1 Gene

Unigene Clusters for BDP1 Gene

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BDP1 Gene

No ASD Table

Relevant External Links for BDP1 Gene

GeneLoc Exon Structure for
BDP1
ECgene alternative splicing isoforms for
BDP1

Expression for BDP1 Gene

mRNA expression in normal human tissues for BDP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for BDP1 Gene

SOURCE GeneReport for Unigene cluster for BDP1 Gene Hs.258272

mRNA Expression by UniProt/SwissProt for BDP1 Gene

A6H8Y1-BDP1_HUMAN
Tissue specificity: Isoform 2 is highly expressed in cerebellum.
genes like me logo Genes that share expressions with BDP1: view

Orthologs for BDP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BDP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BDP1 36
  • 98.57 (n)
  • 97.26 (a)
BDP1 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BDP1 36
  • 80.61 (n)
  • 65.97 (a)
BDP1 37
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BDP1 36
  • 81.54 (n)
  • 68.33 (a)
BDP1 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bdp1 36
  • 71.22 (n)
  • 53.82 (a)
Bdp1 16
Bdp1 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BDP1 37
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 57 (a)
OneToMany
-- 37
  • 31 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
-- 37
  • 28 (a)
OneToMany
chicken
(Gallus gallus)
Aves BDP1 37
  • 59 (a)
OneToOne
LOC427394 36
  • 53.27 (n)
  • 40.01 (a)
lizard
(Anolis carolinensis)
Reptilia BDP1 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4371 36
zebrafish
(Danio rerio)
Actinopterygii BDP1 (1 of 2) 37
  • 19 (a)
OneToMany
BDP1 (2 of 2) 37
  • 22 (a)
OneToMany
Dr.17209 36
fruit fly
(Drosophila melanogaster)
Insecta CG9305 37
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0261.1 37
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BDP1 37
  • 19 (a)
OneToOne
BDP1 39
Species with no ortholog for BDP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BDP1 Gene

ENSEMBL:
Gene Tree for BDP1 (if available)
TreeFam:
Gene Tree for BDP1 (if available)

Paralogs for BDP1 Gene

Pseudogenes.org Pseudogenes for BDP1 Gene

genes like me logo Genes that share paralogs with BDP1: view

No data available for Paralogs for BDP1 Gene

Variants for BDP1 Gene

Sequence variations from dbSNP and Humsavar for BDP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs36092 -- 71,552,603(-) taacc(A/G)cgagt intron-variant
rs40153 -- 71,523,409(+) CCCAG(A/G)TACAA intron-variant
rs149114 -- 71,530,858(-) tcaag(C/T)gatct intron-variant
rs156753 -- 71,523,050(+) AGTCC(A/G)TTAGA intron-variant
rs156754 -- 71,538,250(+) tcata(A/G)tagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BDP1 Gene

Variant ID Type Subtype PubMed ID
nsv428117 CNV Gain+Loss 18775914
dgv6086n71 CNV Gain 21882294
dgv1806e1 CNV Complex 17122850
dgv1810e1 CNV Complex 17122850
nsv528571 CNV Loss 19592680
nsv882176 CNV Loss 21882294
nsv830340 CNV Loss 17160897
dgv6179n71 CNV Loss 21882294
esv1360871 CNV Deletion 17803354

Relevant External Links for BDP1 Gene

HapMap Linkage Disequilibrium report
BDP1
Human Gene Mutation Database (HGMD)
BDP1

Disorders for BDP1 Gene

(1) University of Copenhagen DISEASES for BDP1 Gene

Relevant External Links for BDP1

Genetic Association Database (GAD)
BDP1
Human Genome Epidemiology (HuGE) Navigator
BDP1
genes like me logo Genes that share disorders with BDP1: view

No data available for UniProtKB/Swiss-Prot for BDP1 Gene

Publications for BDP1 Gene

  1. The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1. (PMID: 11161782) Kelter A.R. … Wirth B. (Genomics 2000) 3 4 23
  2. Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB', is an essential component of human TFIIIC1 activity. (PMID: 15096501) Weser S. … Meissner W. (J. Biol. Chem. 2004) 3 4 23
  3. Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. (PMID: 11040218) Schramm L. … Hernandez N. (Genes Dev. 2000) 2 3 4
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for BDP1 Gene

Sources for BDP1 Gene

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