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Aliases for BDP1 Gene

Aliases for BDP1 Gene

  • B Double Prime 1, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase III, GTF3B Subunit 1 2 3
  • Transcription Factor-Like Nuclear Regulator 3 4
  • Transcription Factor IIIB 150 3 4
  • TFIIIB150 3 4
  • TFNR 3 4
  • RNA Polymerase III Transcription Initiation Factor B 3
  • HSA238520 3
  • TFIIIB90 3
  • KIAA1241 4
  • KIAA1689 4
  • TFIIIB 3
  • TAF3B1 3
  • TFC5 3

External Ids for BDP1 Gene

Previous HGNC Symbols for BDP1 Gene

  • TFNR
  • TAF3B1

Previous GeneCards Identifiers for BDP1 Gene

  • GC05P069557
  • GC05P070984
  • GC05P070790
  • GC05P070835
  • GC05P070787
  • GC05P065957

Summaries for BDP1 Gene

Entrez Gene Summary for BDP1 Gene

  • The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for BDP1 Gene

BDP1 (B Double Prime 1, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for BDP1 Gene

  • General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.

Gene Wiki entry for BDP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDP1 Gene

Genomics for BDP1 Gene

Regulatory Elements for BDP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BDP1 Gene

Chromosome:
5
Start:
71,455,383 bp from pter
End:
71,581,062 bp from pter
Size:
125,680 bases
Orientation:
Plus strand

Genomic View for BDP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDP1 Gene

Proteins for BDP1 Gene

  • Protein details for BDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6H8Y1-BDP1_HUMAN
    Recommended name:
    Transcription factor TFIIIB component B homolog
    Protein Accession:
    A6H8Y1
    Secondary Accessions:
    • Q68DS6
    • Q68DY5
    • Q6MZL9
    • Q6PIM7
    • Q86W98
    • Q96LR8
    • Q9C0H4
    • Q9H197
    • Q9H1A1
    • Q9HAW1
    • Q9HAW2
    • Q9HCY0
    • Q9ULH9

    Protein attributes for BDP1 Gene

    Size:
    2624 amino acids
    Molecular mass:
    293885 Da
    Quaternary structure:
    • Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the classical pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43.
    SequenceCaution:
    • Sequence=AAG09268.1; Type=Frameshift; Positions=837, 863; Evidence={ECO:0000305}; Sequence=AAH32146.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86555.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21780.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18085.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BDP1 Gene

neXtProt entry for BDP1 Gene

Proteomics data for BDP1 Gene at MOPED

Post-translational modifications for BDP1 Gene

  • Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BDP1 Gene

No data available for DME Specific Peptides for BDP1 Gene

Domains & Families for BDP1 Gene

Gene Families for BDP1 Gene

Protein Domains for BDP1 Gene

Suggested Antigen Peptide Sequences for BDP1 Gene

Graphical View of Domain Structure for InterPro Entry

A6H8Y1

UniProtKB/Swiss-Prot:

BDP1_HUMAN :
  • Contains 1 Myb-like domain.
Domain:
  • Contains 1 Myb-like domain.
genes like me logo Genes that share domains with BDP1: view

Function for BDP1 Gene

Molecular function for BDP1 Gene

UniProtKB/Swiss-Prot Function:
General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV) resulting in the stimulation of the EBV EBER genes.

Gene Ontology (GO) - Molecular Function for BDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001026 TFIIIB-type transcription factor activity --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with BDP1: view
genes like me logo Genes that share phenotypes with BDP1: view

miRNA for BDP1 Gene

miRTarBase miRNAs that target BDP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BDP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BDP1 Gene

Localization for BDP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BDP1 Gene COMPARTMENTS Subcellular localization image for BDP1 gene
Compartment Confidence
nucleus 4
cytosol 2
endosome 2
vacuole 1

Gene Ontology (GO) - Cellular Components for BDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000126 transcription factor TFIIIB complex --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BDP1: view

Pathways & Interactions for BDP1 Gene

genes like me logo Genes that share pathways with BDP1: view

Gene Ontology (GO) - Biological Process for BDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006359 regulation of transcription from RNA polymerase III promoter --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with BDP1: view

No data available for SIGNOR curated interactions for BDP1 Gene

Drugs & Compounds for BDP1 Gene

No Compound Related Data Available

Transcripts for BDP1 Gene

Unigene Clusters for BDP1 Gene

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BDP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BDP1 Gene

No ASD Table

Relevant External Links for BDP1 Gene

GeneLoc Exon Structure for
BDP1
ECgene alternative splicing isoforms for
BDP1

Expression for BDP1 Gene

mRNA expression in normal human tissues for BDP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BDP1 Gene

This gene is overexpressed in Amniocyte (28.3), Ovary (10.9), Bone marrow mesenchymal stem cell (9.3), and Serum (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BDP1 Gene



SOURCE GeneReport for Unigene cluster for BDP1 Gene Hs.258272

mRNA Expression by UniProt/SwissProt for BDP1 Gene

A6H8Y1-BDP1_HUMAN
Tissue specificity: Isoform 2 is highly expressed in cerebellum.
genes like me logo Genes that share expression patterns with BDP1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for BDP1 Gene

Orthologs for BDP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BDP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BDP1 35
  • 80.61 (n)
  • 65.97 (a)
BDP1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BDP1 35
  • 81.54 (n)
  • 68.33 (a)
BDP1 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bdp1 35
  • 71.22 (n)
  • 53.82 (a)
Bdp1 16
Bdp1 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BDP1 35
  • 98.57 (n)
  • 97.26 (a)
BDP1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BDP1 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC427394 35
  • 53.27 (n)
  • 40.01 (a)
BDP1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BDP1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4371 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17209 35
BDP1 (1 of 2) 36
  • 19 (a)
OneToMany
BDP1 (2 of 2) 36
  • 22 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9305 36
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0261.1 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BDP1 36
  • 19 (a)
OneToOne
BDP1 38
Species with no ortholog for BDP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BDP1 Gene

ENSEMBL:
Gene Tree for BDP1 (if available)
TreeFam:
Gene Tree for BDP1 (if available)

Paralogs for BDP1 Gene

Pseudogenes.org Pseudogenes for BDP1 Gene

genes like me logo Genes that share paralogs with BDP1: view

No data available for Paralogs for BDP1 Gene

Variants for BDP1 Gene

Sequence variations from dbSNP and Humsavar for BDP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_043312 -
VAR_043313 -
VAR_043314 -
VAR_043315 -
VAR_043316 -

Structural Variations from Database of Genomic Variants (DGV) for BDP1 Gene

Variant ID Type Subtype PubMed ID
nsv428117 CNV Gain+Loss 18775914
dgv6086n71 CNV Gain 21882294
dgv1806e1 CNV Complex 17122850
dgv1810e1 CNV Complex 17122850
nsv528571 CNV Loss 19592680
nsv882176 CNV Loss 21882294
nsv830340 CNV Loss 17160897
dgv6179n71 CNV Loss 21882294
esv1360871 CNV Deletion 17803354

Variation tolerance for BDP1 Gene

Residual Variation Intolerance Score: 98.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.89; 91.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BDP1 Gene

HapMap Linkage Disequilibrium report
BDP1
Human Gene Mutation Database (HGMD)
BDP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDP1 Gene

Disorders for BDP1 Gene

Relevant External Links for BDP1

Genetic Association Database (GAD)
BDP1
Human Genome Epidemiology (HuGE) Navigator
BDP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BDP1
genes like me logo Genes that share disorders with BDP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BDP1 Gene

Publications for BDP1 Gene

  1. Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB', is an essential component of human TFIIIC1 activity. (PMID: 15096501) Weser S. … Meissner W. (J. Biol. Chem. 2004) 23 67
  2. Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. (PMID: 11040218) Schramm L. … Hernandez N. (Genes Dev. 2000) 2 67
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  4. The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1. (PMID: 11161782) Kelter A.R. … Wirth B. (Genomics 2000) 23 67
  5. Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. (PMID: 24312468) Girotto G. … Gasparini P. (PLoS ONE 2013) 67

Products for BDP1 Gene

Sources for BDP1 Gene

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