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BDNF Gene

protein-coding   GIFtS: 68
GCID: GC11M027676

Brain-Derived Neurotrophic Factor

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Brain-Derived Neurotrophic Factor1 2
neurotrophin1 2
ANON22 5
BULN22 5
abrineurin2
Abrineurin3

External Ids:    HGNC: 10331   Entrez Gene: 6272   Ensembl: ENSG000001766977   OMIM: 1135055   UniProtKB: P235603   

Export aliases for BDNF gene to outside databases

Previous GC identifers: GC11P029056 GC11M028453 GC11M027715 GC11M027640 GC11M027633 GC11M027374


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BDNF Gene:
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons,
and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both
Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and
in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for
this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for BDNF Gene:
BDNF (brain-derived neurotrophic factor) is a protein-coding gene. Diseases associated with BDNF include mood disorder, and memory impairment. GO annotations related to this gene include growth factor activity and neurotrophin TRKB receptor binding. An important paralog of this gene is NTF4.

UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560
Function: During development, promotes the survival and differentiation of selected neuronal populations of the
peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of
dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in
many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive
neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of
short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability

summary for BDNF Gene:
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase
activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling
pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.
p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds
different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is
involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in
neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is
involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by
neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors
with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as
an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for BDNF (Brain-derived neurotrophic factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the BDNF gene promoter:
         NRSF form 1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): BDNF promoter sequence
   Search Chromatin IP Primers for BDNF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BDNF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14.1

BDNF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDNF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M027676:  view genomic region     (about GC identifiers)

Start:
27,676,440 bp from pter      End:
27,743,605 bp from pter
Size:
67,166 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560 (See protein sequence)
Recommended Name: Brain-derived neurotrophic factor precursor  
Size: 247 amino acids; 27818 Da
Subunit: Monomers and homodimers. Binds to NTRK2/TRKB
2 PDB 3D structures from and Proteopedia for BDNF:
1B8M (3D)        1BND (3D)    
Secondary accessions: A7LA85 A7LA92 D3DQZ2 Q598Q1 Q6DN19 Q6YNR2 Q6YNR3 Q9BYY7 Q9UC24
Alternative promoter usage, Alternative splicing: 5 isoforms:  P23560-1   P23560-2   P23560-3   P23560-4   P23560-5   

Explore the universe of human proteins at neXtProt for BDNF: NX_P23560

Explore proteomics data for BDNF at MOPED

Post-translational modifications: 

  • The propeptide is N-glycosylated and glycosulfated1
  • Converted into mature BDNF by plasmin (PLG) (By similarity)1
  • Glycosylation2 at Asn121
  • Modification sites at PhosphoSitePlus

  • See BDNF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (17 alternative transcripts): 
    NP_001137277.1  NP_001137278.1  NP_001137279.1  NP_001137280.1  NP_001137281.1  NP_001137282.1  NP_001137283.1  NP_001137284.1  
    NP_001137285.1  NP_001137286.1  NP_001137288.1  NP_001700.2  NP_733927.1  NP_733928.1  NP_733929.1  NP_733930.1  
    NP_733931.1  

    ENSEMBL proteins: 
     ENSP00000389345   ENSP00000437138   ENSP00000379309   ENSP00000432727   ENSP00000349084  
     ENSP00000400502   ENSP00000432376   ENSP00000435564   ENSP00000433003   ENSP00000379307  
     ENSP00000414303   ENSP00000435805   ENSP00000379305   ENSP00000379302   ENSP00000432035  
     ENSP00000320002   ENSP00000379304   ENSP00000389564  

    BDNF Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for BDNF
    Enzo Life Sciences proteins for BDNF
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    OriGene Protein Over-expression Lysate for BDNF
    OriGene MassSpec for BDNF
    OriGene Custom Protein Services for BDNF
    GenScript Custom Purified and Recombinant Proteins Services for BDNF
    Novus Biologicals BDNF Proteins
    Novus Biologicals BDNF Lysates
    Sino Biological Recombinant Protein for BDNF
    Sino Biological Cell Lysate for BDNF
    ProSpec Recombinant Protein for BDNF
    Cloud-Clone Corp. Proteins for BDNF

    BDNF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BDNF
    R&D Systems Antibodies for BDNF
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    OriGene Custom Antibody Services for BDNF
    Novus Biologicals BDNF Antibodies
    Abcam antibodies for BDNF
    Cloud-Clone Corp. Antibodies for BDNF
    ThermoFisher Antibodies for BDNF
    LSBio Antibodies in human, mouse, rat for BDNF

    BDNF Assay Products:

    EMD Millipore Kits and Assays for the Analysis of BDNF
    OriGene Custom Assay Services for BDNF
    R&D Systems Flow Cytometry Kits for BDNF         (see all)
    GenScript Custom Assay Services for BDNF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BDNF
    Cloud-Clone Corp. CLIAs for BDNF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR020430 Brain-der_neurotrophic_factor
     IPR002072 Nerve_growth_factor-rel
     IPR019846 Nerve_growth_factor_CS
     IPR020408 Nerve_growth_factor-like

    Graphical View of Domain Structure for InterPro Entry P23560

    ProtoNet protein and cluster: P23560

    1 Blocks protein domain: IPB002072 Nerve growth factor

    UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560
    Similarity: Belongs to the NGF-beta family


    BDNF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BDNF_HUMAN, P23560
    Function: During development, promotes the survival and differentiation of selected neuronal populations of the
    peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of
    dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in
    many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive
    neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of
    short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability

         Genatlas biochemistry entry for BDNF:
    brain-derived neurotrophic factor (neurotrophin 2) ligand for NTRK2 (TRKB),expressed in retina and the anterior
    segment of the developing eye

         Summary: 
    During embryonic development, BDNF as signaling molecule affects the following cells:
    Peripheral Nervous System: Immature Schwann Cells (Peripheral Nerve Domain)

    BDNF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 5)      fully expand
    Spinal Cord: Retinoic acid- and Sonic hedgehog-induced neural rosettes , Precursor lateral motor column neuron EBs      fully expand to see all 10 cells
    Neurons: Motor neuron-like cells, Motor neuron-like and interneuron-like cells (Mm)      fully expand to see all 10 cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005169neurotrophin TRKB receptor binding IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    BDNF for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 23 alleles(MGI details for Bdnf) (see all 16):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  integument  mortality/aging  nervous system 
     no phenotypic analysis  normal  reproductive system  respiratory system  taste/olfaction 

    BDNF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BDNF: Bdnftm1Lfr Bdnftm1Par Bdnftm1Tbn Bdnftm1Jae Bdnftm1Gdy

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BDNF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BDNF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BDNF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BDNF

    miRNA
    Products:
        
    miRTarBase miRNAs that target BDNF:
    hsa-mir-22-3p (MIRT005900), hsa-mir-210-3p (MIRT003153), hsa-mir-1 (MIRT002955)

    Block miRNA regulation of human, mouse, rat BDNF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BDNF (see all 108):
    hsa-miR-549 hsa-miR-579 hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-218-1* hsa-miR-134
    SwitchGear 3'UTR luciferase reporter plasmidBDNF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BDNF
    Predesigned siRNA for gene silencing in human, mouse, rat BDNF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BDNF

    Clone
    Products:
         
    OriGene clones in human, mouse for BDNF (see all 93)
    OriGene ORF clones in mouse, rat for BDNF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 17): BDNF (NM_170731)
    Sino Biological Human cDNA Clone for BDNF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BDNF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BDNF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BDNF
    Browse ESI BIO Cell Lines and PureStem Progenitors for BDNF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BDNF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BDNF_HUMAN, P23560: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton3
    nucleus3
    endoplasmic reticulum2
    mitochondrion2
    plasma membrane2
    cytosol1
    endosome1
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm ISS--
    GO:0008021synaptic vesicle IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle ----
    GO:0048471perinuclear region of cytoplasm ISS--

    BDNF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BDNF About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BDNF
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BDNF (see all 60)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for BDNF
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    Selected BioSystems Pathways for BDNF (see all 8)
        MAPK signaling pathway
    SIDS Susceptibility Pathways
    BDNF signaling pathway
    Spinal Cord Injury
    Integrated Pancreatic Cancer Pathway



    5 Kegg Pathways  (Kegg details for BDNF):
        MAPK signaling pathway
    Neurotrophin signaling pathway
    Huntington's disease
    Cocaine addiction
    Alcoholism


    BDNF for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BDNF (see all 16): 
              Parkinson's Disease in human mouse rat
              Neurogenesis in human mouse rat
              GABA & Glutamate in human mouse rat
              Alzheimer's Disease in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BDNF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BDNF (P235601, 2, 3 ENSP000004143034) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTF3P207831, 2, 3, ENSP000003972974EBI-1026003,EBI-1025994 MINT-24751 I2D: score=4 STRING: ENSP00000397297
    CADPS2Q86UW73, ENSP000004004014I2D: score=1 STRING: ENSP00000400401
    NGFRP081383, ENSP000001722294I2D: score=1 STRING: ENSP00000172229
    NTF4P341303, ENSP000003014114I2D: score=1 STRING: ENSP00000301411
    PLGP007473, ENSP000003089384I2D: score=1 STRING: ENSP00000308938
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001657ureteric bud development IEA--
    GO:0001662behavioral fear response IEA--
    GO:0001666response to hypoxia IEA--
    GO:0002544chronic inflammatory response IEA--
    GO:0006120mitochondrial electron transport, NADH to ubiquinone IEA--

    BDNF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for BDNF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BDNF (human)Activates TrkB and p75 receptors[218441-99-7]
    ANA 12TrkB receptor antagonist[219766-25-3]
    GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
    TLQP 21VGF-derived peptide[869988-94-3]
    7,8-Dihydroxyflavone TrkB agonist[38183-03-8]

    Selected Novoseek inferred chemical compound relationships for BDNF gene (see all 157)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 87 51 18289471 (2), 18959266 (2), 17880937 (2), 11698603 (1) (see all 34)
    tyrosine 72.2 230 9645956 (4), 10486198 (4), 15519688 (3), 10777780 (2) (see all 99)
    nmda 62.3 215 10212287 (7), 11594735 (7), 9792641 (5), 15519688 (5) (see all 81)
    glutamate 58.8 165 16337157 (6), 7684481 (6), 19570026 (5), 12470709 (4) (see all 90)
    dopamine 54.2 143 10718305 (5), 8566202 (4), 8090745 (4), 9671688 (4) (see all 70)
    rasagiline 53.3 8 17055733 (1), 18077571 (1), 17701352 (1), 19673610 (1) (see all 5)
    propargylamine 52.5 1 16148027 (1)
    axokine 51.7 4 10235570 (2), 9501871 (1)
    glatiramer acetate 49 45 12390966 (4), 16934924 (3), 17439900 (3), 15869765 (3) (see all 10)
    mhpg 48.3 30 17459549 (5), 18160197 (3), 18781277 (2), 19946939 (1) (see all 9)

    8 PharmGKB related drug/compound annotations for BDNF gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  
    desipramineCA  
    escitalopramCA  
    fluoxetineCA  
    methadoneCA  
    nortriptylineCA  
    paroxetineCA  



    BDNF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BDNF gene (18 alternative transcripts): 
    NM_001143805.1  NM_001143806.1  NM_001143807.1  NM_001143808.1  NM_001143809.1  NM_001143810.1  NM_001143811.1  NM_001143812.1  
    NM_001143813.1  NM_001143814.1  NM_001143816.1  NM_001709.4  NM_170731.4  NM_170732.4  NM_170733.3  NM_170734.3  
    NM_170735.5  NM_001143815.1  

    Unigene Cluster for BDNF:

    Brain-derived neurotrophic factor
    Hs.502182  [show with all ESTs]
    Unigene Representative Sequence: EF689009
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000439476(uc010rdu.2) ENST00000525528(uc021qff.1) ENST00000395986(uc001mrt.3)
    ENST00000533131 ENST00000356660(uc001mru.3) ENST00000418212(uc009yjd.3)
    ENST00000533246(uc010rdw.2) ENST00000530861(uc010rdx.2) ENST00000530786
    ENST00000395983(uc010rdy.2 uc009yjf.3) ENST00000438929(uc009yje.3)
    ENST00000584049 ENST00000532997(uc001mrw.4) ENST00000395981(uc001mrx.3)
    ENST00000395978(uc001mry.4) ENST00000525950(uc001mrz.4) ENST00000314915(uc001msa.3)
    ENST00000395980(uc001mrv.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat BDNF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BDNF (see all 108):
    hsa-miR-549 hsa-miR-579 hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-218-1* hsa-miR-134
    SwitchGear 3'UTR luciferase reporter plasmidBDNF 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BDNF
    Predesigned siRNA for gene silencing in human, mouse, rat BDNF
    Clone
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    OriGene clones in human, mouse for BDNF (see all 93)
    OriGene ORF clones in mouse, rat for BDNF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 17): BDNF (NM_170731)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BDNF
    Primer
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    Additional mRNA sequence: 

    AB038670.1 AB038671.1 AB038672.1 AB038673.1 AB038674.1 AF400438.1 AK289763.1 AK289853.1 
    AY054392.2 AY054393.2 AY054394.2 AY054395.2 AY054396.2 AY054397.2 AY054398.2 AY054399.2 
    AY054400.2 AY054406.3 AY442188.1 AY656701.1 BC029795.1 DQ250642.1 EF674517.1 EF674518.1 
    EF674519.1 EF674520.1 EF674521.1 EF689009.1 EF689010.1 EF689011.1 EF689012.1 EF689013.1 
    EF689014.1 EF689015.1 EF689016.1 EF689017.1 EF689018.1 EF689019.1 EF689020.1 EF689021.1 
    M61176.1 X60201.1 X91251.1 

    14 DOTS entries:

    DT.95167621  DT.411992  DT.95167624  DT.95337925  DT.95167619  DT.91653427  DT.95167620  DT.91753544 
    DT.100794512  DT.100794510  DT.100794513  DT.100008355  DT.120745545  DT.40291086 

    6 AceView cDNA sequences:

    AY513486 BG707452 AY054404 AY054402 AY054401 BG707369 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BDNF (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
    SP1:                                      -     -     -     -                                 
    SP2:                                            -     -     -                                 
    SP3:                                                  -     -                                 
    SP4:                                                        -                                 
    SP5:        -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for BDNF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BDNF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BDNF Expression
    About this image


    BDNF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Cerebellum
             Encapsulated choroid plexus cells (NTCELL)
             Astrocyte-like cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical tissue-derived cells (CNTO2476)
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Motor neuron progenitor cells
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Schwann-like cells
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Somatic Cells Ovigerous Cord
             Oviduct
    BDNF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BDNF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502182

    UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560
    Tissue specificity: Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also
    expressed in heart, lung, skeletal muscle, testis, prostate and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BDNF (see all 16): 
              Parkinson's Disease in human mouse rat
              Neurogenesis in human mouse rat
              GABA & Glutamate in human mouse rat
              Alzheimer's Disease in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for BDNF gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bdnf1 , 5 brain derived neurotrophic factor1, 5 92.26(n)1
    97.64(a)1
      2 (56.63 cM)5
    120641  NM_007540.41  NP_031566.41 
     1096747005 
    chicken
    (Gallus gallus)
    Aves BDNF1 brain-derived neurotrophic factor 85.91(n)
    91.87(a)
      396186  NM_001031616.1  NP_001026787.1 
    lizard
    (Anolis carolinensis)
    Reptilia BDNF6
    Brain-derived neurotrophic factor; Uncharacterized...
    87(a)
    1 ↔ 1
    GL343314.1(275643-276311)
    African clawed frog
    (Xenopus laevis)
    Amphibia bdnf-A2 brain-derived neurotrophic factor 86.49(n)    X61477.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bdnf2 brain-derived neurotrophic factor 81.04(n)   58118  BC058301.1 


    ENSEMBL Gene Tree for BDNF (if available)
    TreeFam Gene Tree for BDNF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for BDNF gene
    NTF42  NTF32  NGF2  
    5 SIMAP similar genes for BDNF using alignment to 5 protein entries:     BDNF_HUMAN (see all proteins):
    BDNF 1-5    BDNF 2-5    NTF3    NGF    NTF4

    BDNF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    BDNF_HUMAN, P23560: Variations in BDNF are associated with susceptibility to bulimia nervosa 2 (BULN2) [MIM:610269].
    Several genes with an essential role in the regulation of eating behavior and body weight are considered
    candidates involved in the etiology of eating disorders (ED), but no relevant susceptibility genes with a major
    effect on anorexia nervosa (AN) or bulimia nervosa (BN) have been identified. BDNF has been implicated in the
    regulation of food intake and body weight in rodents. A strong association has been reported of the Met-66 allele
    of the Val-66-Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients.
    Met-66 variant is strongly associated to all ED subtypes (AN, ANR, binge-eating/purging AN and BN) in European
    patients. Another single nucleotide polymorphism located in the promoter region of the BDNF gene showed an effect
    on BN and late age at onset of weight loss. These are two variants associated with the pathophysiology of ED in
    different populations. These variants support a role for BDNF in the susceptibility to aberrant eating behaviors


    Selected SNPs for BDNF (see all 1090)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81924661,2,,4
    C,F,HCongenital central hypoventilation syndrome (CCHS)4 pathogenic127608216(-) GATGAC/TCATCC 34 T I mis19Minor allele frequency- T:0.00NS EA NA EU 6171
    rs62651,2,,4
    C,F,O,A,Hother127608025(-) AACACG/ATGATA 34 /M /V mis139Minor allele frequency- A:0.18MN NS EA NA EU 9503
    rs57906611,2
    H--27379341(+) gtgtgC/Tgcgcg 17 -- int1 us2k10--------
    rs2006270591,2
    --27420247(+) CCCCC-/GCCCCC 15 -- int1 us2k10--------
    rs113751491,2
    C--27428300(+) TACTCT/-TTAAT 5 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1438312771,2
    C--27436121(+) AGAAA-/ACACACA 5 -- int10--------
    rs1845669841,2
    C--27436122(+) GAAAAA/CACACA 5 -- int10--------
    rs1855888541,2
    --27604370(+) TTCTCA/GGAAGC 17 -- ds50010--------
    rs31787391,2
    C--27604753(-) TATTCA/CCCATG 17 -- ut31 ese33Minor allele frequency- C:0.00MN NA 188
    rs1911377571,2
    --27604783(+) AACAAC/GGCCAC 17 -- ut310--------

    HapMap Linkage Disequilibrium report for BDNF (27676440 - 27743605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BDNF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819223CNV Gain19587683
    nsv832095CNV Gain17160897

    Human Gene Mutation Database (HGMD): BDNF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BDNF
    DNA2.0 Custom Variant and Variant Library Synthesis for BDNF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 113505   
    OMIM disorders: 209880  164230  607499  610269  
    UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560
  • Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal
    control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A
    deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal
    responses to hypercapnia and hypoxemia. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for BDNF (see all 189):    
    About MalaCards
    mood disorder    memory impairment    reversible cerebral vasoconstriction syndrome    conversion disorder
    obsessive-compulsive disorder, protection against    bulimia nervosa, age of onset of weight loss in    bulimia nervosa    cannabis abuse
    phobic disorder    wagro syndrome    anorexia nervosa    fetal alcohol spectrum disorder
    congenital central hypoventilation syndrome    sydenham's chorea    wagr syndrome    central hypoventilation syndrome
    huntington's disease    obsessive-compulsive disorder    aniridia    transient global amnesia

    16 diseases from the University of Copenhagen DISEASES database for BDNF:
    Schizophrenia     Huntington's disease     Alzheimer's disease     Parkinson's disease
    Toxic encephalopathy     Rett syndrome     Cerebrovascular accident     Amyotrophic lateral sclerosis
    Autistic disorder     Multiple sclerosis     Brain ischemia     Neuroblastoma
    Attention deficit hyperactivity disorder     Anxiety disorder     Bipolar disorder     Glaucoma

    BDNF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for BDNF gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 69.9 49 19498435 (2), 19748969 (2), 8197193 (1), 7523178 (1) (see all 39)
    bipolar disorder 68.6 111 17012654 (5), 17464718 (5), 16568151 (4), 16388065 (3) (see all 60)
    major depression 67.5 130 19371767 (4), 15291244 (4), 18406398 (4), 18329817 (3) (see all 62)
    mood disorders 67.4 91 15145621 (5), 20013430 (5), 19473771 (4), 15626819 (3) (see all 56)
    schizophrenia 62 269 19368899 (8), 19720106 (6), 15276697 (6), 17464718 (5) (see all 99)
    alzheimers disease 61.4 109 12456067 (3), 12654514 (3), 12358753 (3), 16362629 (3) (see all 70)
    huntington disease 61.3 39 19498435 (3), 18093249 (2), 17096834 (2), 17427191 (2) (see all 29)
    neurodegeneration 54.9 24 10867782 (1), 17990049 (1), 19679106 (1), 15262269 (1) (see all 16)
    rett syndrome 54.6 16 19349604 (3), 16996699 (2), 19096215 (1), 16446133 (1) (see all 12)
    parkinson disease 53.2 68 15666411 (3), 8197193 (2), 17069877 (2), 11040419 (2) (see all 45)

    Genetic Association Database (GAD): BDNF
    Human Genome Epidemiology (HuGE) Navigator: BDNF (536 documents)

    Export disorders for BDNF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BDNF gene, integrated from 10 sources (see all 2645):
    (articles sorted by number of sources associating them with BDNF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Brain-derived neurotrophic factor and obesity in the WAGR syndrome. (PubMed id 18753648)1, 2, 4, 9 Han J.C.... Yanovski J.A. (N. Engl. J. Med. 2008)
    2. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PubMed id 1889806)1, 2, 3, 9 Maisonpierre P.C....Yancopoulos G.D. (Genomics 1991)
    3. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. (PubMed id 12836135)1, 2, 4, 9 Hall D.... Karayiorgou M. (Am. J. Hum. Genet. 2003)
    4. Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. (PubMed id 15115760)1, 2, 4 Ribases M.... Estivill X. (Hum. Mol. Genet. 2004)
    5. Molecular cloning of a human gene that is a member of the nerve growth factor family. (PubMed id 2236018)1, 2, 3 Jones K.R. and Reichardt L.F. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    6. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. (PubMed id 15899246)1, 4, 9 Lee J....Ingelsson M. (Exp. Neurol. 2005)
    7. The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels. (PubMed id 19589373)1, 4, 9 Ozan E....Akarsu N. (Brain Res. Bull. 2010)
    8. Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. (PubMed id 18505307)1, 4, 9 Yu H....Deng L. (J Clin Psychiatry 2008)
    9. The common BDNF polymorphism may be a modifier of disease severity in Rett syndrome. (PubMed id 19349604)1, 4, 9 Zeev B.B....Christodoulou J. (Neurology 2009)
    10. [Cognitive function, serum BDNF levels and BDNF gene Val66Met polymorphism in amnestic mild cognitive impairment]. (PubMed id 18460776)1, 4, 9 Yu H....Deng L.L. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 627 HGNC: 1033 AceView: BDNF.1 Ensembl:ENSG00000176697 euGenes: HUgn627
    ECgene: BDNF Kegg: 627 H-InvDB: BDNF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BDNF Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BDNF gene:
    Search GeneIP for patents involving BDNF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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