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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BDNF Gene

protein-coding GIFtS: 69
GCID: GC11M027676

brain-derived neurotrophic factor

Explore 176 diseases affiliated with
BDNF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Brain-Derived Neurotrophic Factor¹ ²
ANON2²
BULN2²
Abrineurin³
Neurotrophin¹
Abrineurin³

External Ids:	HGNC: 1033¹	Entrez Gene: 627²	Ensembl: ENSG00000176697⁷	OMIM: 113505⁵	UniProtKB: P23560³

Export aliases for BDNF gene to outside databases

Previous GC identifers: GC11P029056 GC11M028453 GC11M027715 GC11M027640 GC11M027633 GC11M027374

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BDNF:

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and

is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and

Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood

disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. (provided by

RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560

Function: During development, promotes the survival and differentiation of selected neuronal populations of the

peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic

growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of

the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including

long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as

homeostatic regulation of intrinsic neuronal excitability

summary for BDNF:

Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase

activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling

pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.

p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds

different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is

involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in

neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is

involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by

neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors

with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as

an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for BDNF (Brain-derived neurotrophic factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BDNF gene promoter:
NRSF form 1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): BDNF promoter sequence

Search SABiosciences Chromatin IP Primers for BDNF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BDNF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p14.1 HGNC cytogenetic band: 11p14.1

BDNF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDNF gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M027676: view genomic region (about GC identifiers)

Start:	27,676,440 bp from pter	End:	27,743,605 bp from pter
Size:	67,166 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560 (See protein sequence)

Recommended Name: Brain-derived neurotrophic factor precursor

Size: 247 amino acids; 27818 Da

Subunit: Monomers and homodimers. Binds to NTRK2/TRKB

Subcellular location: Secreted

2 PDB 3D structures from and Proteopedia for BDNF:

1B8M (3D)

1BND (3D)

Secondary accessions: A7LA85 A7LA92 D3DQZ2 Q598Q1 Q6DN19 Q6YNR2 Q6YNR3 Q9BYY7 Q9UC24

Alternative promoter usage, Alternative splicing: 5 isoforms: P23560-1 P23560-2 P23560-3 P23560-4 P23560-5

Explore the universe of human proteins at neXtProt for BDNF: NX_P23560

Post-translational modifications:

The propeptide is N-glycosylated and glycosulfated¹

Converted into mature BDNF by plasmin (PLG) (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23560

BDNF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (17 alternative transcripts):

NP_001137277.1 NP_001137278.1 NP_001137279.1 NP_001137280.1 NP_001137281.1 NP_001137282.1 NP_001137283.1 NP_001137284.1

NP_001137285.1 NP_001137286.1 NP_001137288.1 NP_001700.2 NP_733927.1 NP_733928.1 NP_733929.1 NP_733930.1

NP_733931.1

ENSEMBL proteins:

ENSP00000389345 ENSP00000437138 ENSP00000379309 ENSP00000432727 ENSP00000349084

ENSP00000400502 ENSP00000432376 ENSP00000435564 ENSP00000433003 ENSP00000379307

ENSP00000414303 ENSP00000435805 ENSP00000379305 ENSP00000379302 ENSP00000432035

ENSP00000320002 ENSP00000431998 ENSP00000379304 ENSP00000389564

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant BDNF Protein
	R&D Systems Recombinant & Natural Proteins for BDNF
	Enzo Life Sciences proteins for BDNF
	OriGene Purified Protein: BDNF OriGene Protein Over-expression Lysate (see all 17): BDNF OriGene Custom Protein Services for BDNF
	GenScript Custom Purified and Recombinant Proteins Services for BDNF
	Novus Biologicals BDNF Proteins Novus Biologicals BDNF Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for BDNF
	Uscn Proteins for BDNF

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005737	cytoplasm	ISS	--
GO:0008021	synaptic vesicle	IEA	--
GO:0016023	cytoplasmic membrane-bounded vesicle	--	--
GO:0048471	perinuclear region of cytoplasm	ISS	--

BDNF for ontologies About GeneDecksing

BDNF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BDNF
	R&D Systems Antibodies for BDNF
	OriGene Antibodies (see all 2): BDNF OriGene Custom Antibody Services for BDNF
	GenScript Superior Antibodies for BDNF
	Novus Biologicals BDNF Antibodies
	Abcam antibodies for BDNF
	Uscn Antibodies for BDNF
	ThermoFisher Antibodies for BDNF

Assay Products for BDNF:

	EMD Millipore Kits and Assays for the Analysis of BDNF
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for BDNF
	GenScript Custom Assay Services for BDNF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BDNF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BDNF for domains About GeneDecksing

4 InterPro domains/families:

IPR020430 Brain-der_neurotrophic_factor

IPR019846 Nerve_growth_factor_CS

IPR002072 Nerve_growth_factor-rel

IPR020408 Nerve_growth_factor-like

Graphical View of Domain Structure for InterPro Entry P23560

ProtoNet protein and cluster: P23560

1 Blocks protein family: IPB002072 Nerve growth factor

UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560

Similarity: Belongs to the NGF-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560

Function: During development, promotes the survival and differentiation of selected neuronal populations of the

peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic

growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of

the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including

long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as

homeostatic regulation of intrinsic neuronal excitability

Genatlas biochemistry entry for BDNF:

brain-derived neurotrophic factor (neurotrophin 2) ligand for NTRK2 (TRKB),expressed in retina and the anterior segment

of the developing eye

Summary:

BDNF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Motor neuron-like cells, Motor neuron-like cells (see all 20).

miRNA Products:		miRTarBase miRNAs that target BDNF: hsa-mir-22 (MIRT005900), hsa-mir-210 (MIRT003153), hsa-mir-1 (MIRT002955)

		OriGene 3'-UTR Clone (see all 17): BDNF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BDNF
		8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate BDNF (see all 108):
		hsa-miR-549 hsa-miR-579 hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-218-1* hsa-miR-134

		SwitchGear 3'UTR luciferase reporter plasmid: BDNF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BDNF (see all 7) OriGene shRNA RFP: BDNF OriGene siRNA: BDNF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BDNF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BDNF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BDNF (see all 20) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BDNF (see all 18) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 17): BDNF (NM_170731)
		Sino Biological Human cDNA Clone for BDNF
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BDNF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BDNF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BDNF
		Search LifeMap BioReagents cell lines for BDNF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BDNF

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005169	neurotrophin TRKB receptor binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008083	growth factor activity	IEA	--

BDNF for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for BDNF: Bdnf^tm1Lfr Bdnf^tm1Par Bdnf^tm1Tbn Bdnf^tm1Jae Bdnf^tm1Gdy
     15/16 MGI mutant phenotypes (inferred from 23 alleles) (MGI details for Bdnf) (see all 16):

behavior/neurological	cellular	craniofacial	digestive/alimentary	growth/size
hearing/vestibular/ear	homeostasis/metabolism	integument	mortality/aging	nervous system
no phenotypic analysis	normal	reproductive system	respiratory system	taste/olfaction

BDNF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			JNK Pathway	0.50

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for BDNF

	Development Neurotrophin family signaling
	Development MAG-dependent inhibition of neurite outgrowth

1 R&D Systems Pathway for BDNF

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/60 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BDNF (see all 60)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

2 GeneGo (Thomson Reuters) Pathways for BDNF

	Development Neurotrophin family signaling
	Development MAG-dependent inhibition of neurite outgrowth

5/7 BioSystems Pathways for BDNF (see all 7)

	SIDS Susceptibility Pathways
	MAPK signaling pathway
	FSH signaling pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway

3 Kegg Pathways (Kegg details for BDNF):

	MAPK signaling pathway
	Neurotrophin signaling pathway
	Huntington's disease

BDNF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BDNF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for BDNF (P23560^{1, 2, 3} ENSP00000414303⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NTF3	P20783¹^,²^,³, ENSP00000397297⁴	EBI-1026003,EBI-1025994 MINT-24751 I2D: score=4 STRING: ENSP00000397297
CADPS2	Q86UW7³, ENSP00000400401⁴	I2D: score=1 STRING: ENSP00000400401
NGFR	P08138³, ENSP00000172229⁴	I2D: score=1 STRING: ENSP00000172229
NTF4	P34130³, ENSP00000301411⁴	I2D: score=1 STRING: ENSP00000301411
PLG	P00747³, ENSP00000308938⁴	I2D: score=1 STRING: ENSP00000308938

About this table

Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001657	ureteric bud development	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0002544	chronic inflammatory response	IEA	--
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	IEA	--
GO:0007399	nervous system development	TAS	2236018

BDNF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BDNF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for BDNF available from Tocris Bioscience About this table

Compound	Action	CAS #
BDNF (human)	Activates TrkB and p75 receptors	[218441-99-7]

10/157 Novoseek chemical compound relationships for BDNF gene (see all 157) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
k252a	87	51	18289471 (2), 18959266 (2), 17880937 (2), 11698603 (1) (see all 34)
tyrosine	72.2	230	9645956 (4), 10486198 (4), 15519688 (3), 10777780 (2) (see all 99)
nmda	62.3	215	10212287 (7), 11594735 (7), 9792641 (5), 15519688 (5) (see all 81)
glutamate	58.8	165	16337157 (6), 7684481 (6), 19570026 (5), 12470709 (4) (see all 90)
dopamine	54.2	143	10718305 (5), 8566202 (4), 8090745 (4), 9671688 (4) (see all 70)
rasagiline	53.3	8	17055733 (1), 18077571 (1), 17701352 (1), 19673610 (1) (see all 5)
propargylamine	52.5	1	16148027 (1)
axokine	51.7	4	10235570 (2), 9501871 (1)
glatiramer acetate	49	45	12390966 (4), 16934924 (3), 17439900 (3), 15869765 (3) (see all 10)
mhpg	48.3	30	17459549 (5), 18160197 (3), 18781277 (2), 19946939 (1) (see all 9)

3 PharmGKB related drug/compound annotations for BDNF gene

Drug/compound	PharmGKB Annotation
antidepressants	CA
desipramine	CA
fluoxetine	CA

About this table

Search CenterWatch for drugs/clinical trials and news about BDNF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BDNF gene (18 alternative transcripts):

NM_001143805.1 NM_001143806.1 NM_001143807.1 NM_001143808.1 NM_001143809.1 NM_001143810.1 NM_001143811.1 NM_001143812.1

NM_001143813.1 NM_001143814.1 NM_001143816.1 NM_001709.4 NM_170731.4 NM_170732.4 NM_170733.3 NM_170734.3

NM_170735.5 NM_001143815.1

Unigene Cluster for BDNF:

Brain-derived neurotrophic factor

Hs.502182 [show with all ESTs]

Unigene Representative Sequence: EF689009

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000439476(uc010rdu.2) ENST00000525528(uc021qff.1) ENST00000395986(uc001mrt.3)

ENST00000533131 ENST00000356660(uc001mru.3) ENST00000418212(uc009yjd.3)

ENST00000533246(uc010rdw.2) ENST00000530861(uc010rdx.2) ENST00000530786

ENST00000395983(uc010rdy.2 uc009yjf.3) ENST00000438929(uc009yje.3)

ENST00000584049 ENST00000532997(uc001mrw.4) ENST00000395981(uc001mrx.3)

ENST00000395978(uc001mry.4) ENST00000525950(uc001mrz.4) ENST00000314915(uc001msa.3)

ENST00000528035

miRNA Products:		OriGene 3'-UTR Clone (see all 17): BDNF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BDNF
		8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate BDNF (see all 108):
		hsa-miR-549 hsa-miR-579 hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-218-1* hsa-miR-134

		SwitchGear 3'UTR luciferase reporter plasmid: BDNF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BDNF (see all 7) OriGene shRNA RFP: BDNF OriGene siRNA: BDNF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BDNF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BDNF (see all 20) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BDNF (see all 18) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 17): BDNF (NM_170731)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BDNF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BDNF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BDNF Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BDNF
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BDNF

Additional cDNA sequence:

AB038670.1 AB038671.1 AB038672.1 AB038673.1 AB038674.1 AF400438.1 AK289763.1 AK289853.1

AY054392.2 AY054393.2 AY054394.2 AY054395.2 AY054396.2 AY054397.2 AY054398.2 AY054399.2

AY054400.2 AY054406.3 AY442188.1 AY656701.1 BC029795.1 DQ250642.1 EF674517.1 EF674518.1

EF674519.1 EF674520.1 EF674521.1 EF689009.1 EF689010.1 EF689011.1 EF689012.1 EF689013.1

EF689014.1 EF689015.1 EF689016.1 EF689017.1 EF689018.1 EF689019.1 EF689020.1 EF689021.1

M61176.1 X60201.1 X91251.1

14 DOTS entries:

DT.95167621 DT.411992 DT.95167624 DT.95337925 DT.95167619 DT.91653427 DT.95167620 DT.91753544

DT.100794512 DT.100794510 DT.100794513 DT.40291086 DT.100008355 DT.120745545

6 AceView cDNA sequences:

AY513486 BG707452 AY054401 AY054402 AY054404 BG707369

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for BDNF (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d	·	8e
SP1:													-		-		-		-
SP2:															-		-		-
SP3:																	-		-
SP4:																			-
SP5:			-		-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for BDNF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BDNF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

BDNF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Substantia Nigra pars Compacta

Adult Dopaminergic Neurons

Dopaminergic neurons

Brain

Substantia Nigra pars Compacta

Embryonic Dopaminergic Neurons

Dopaminergic neurons

Brain

Ventral Tegmental Area

Adult Dopaminergic Neurons

Dopaminergic neurons

Brain

Ventral Tegmental Area

Embryonic Dopaminergic Neurons

Dopaminergic neurons

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Bone

Maxillary Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

See BDNF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BDNF

SOURCE GeneReport for Unigene cluster: Hs.502182

UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560

Tissue specificity: Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in

heart, lung, skeletal muscle, testis, prostate and placenta

SABiosciences Expression via Pathway-Focused PCR Arrays including BDNF (see all 16):

Parkinson's Disease in human mouse rat

Neurogenesis in human mouse rat

GABA & Glutamate in human mouse rat

Alzheimer's Disease in human mouse rat

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BDNF gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BDNF¹	brain-derived neurotrophic factor	85.91(n) 91.87(a)		396186 NM_001031616.1 NP_001026787.1
lizard (Anolis carolinensis)	Reptilia	C5H0G8_ANOCA⁶	Brain-derived neurotrophic factor Fragment	86(a)	1 ↔ 1	GL343314.1(275643-276311)
African clawed frog (Xenopus laevis)	Amphibia	bdnf-A²	brain-derived neurotrophic factor	86.49(n)		X61477.1
zebrafish (Danio rerio)	Actinopterygii	bdnf²	brain-derived neurotrophic factor	81.04(n)		58118 BC058301.1

ENSEMBL Gene Tree for BDNF (if available)
TreeFam Gene Tree for BDNF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BDNF gene

NTF3² NTF4² NGF²

5 SIMAP similar genes for BDNF using alignment to 5 protein entries: BDNF_HUMAN (see all proteins):

BDNF 1-5 BDNF 2-5 NTF3 NGF NTF4

BDNF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560

Polymorphism: Variations in BDNF are associated with susceptibility to bulimia nervosa 2 (BULN2) [MIM:610269]. Several

genes with an essential role in the regulation of eating behavior and body weight are considered candidates involved

in the etiology of eating disorders (ED), but no relevant susceptibility genes with a major effect on anorexia nervosa

(AN) or bulimia nervosa (BN) have been identified. BDNF has been implicated in the regulation of food intake and body

weight in rodents. A strong association has been reported of the Met-66 allele of the Val-66-Met BDNF variant with

restricting AN (ANR) and low minimum body mass index in Spanish patients. Met-66 variant is strongly associated to all

ED subtypes (AN, ANR, binge-eating/purging AN and BN) in European patients. Another single nucleotide polymorphism

located in the promoter region of the BDNF gene showed an effect on BN and late age at onset of weight loss. These are

two variants associated with the pathophysiology of ED in different populations. These variants support a role for

BDNF in the susceptibility to aberrant eating behaviors

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8192466^1,2	C,F,H,	pathogenic	73853830(-)	`GATGAC/TCATCC`	34	T I	mis¹		9		NS EA NA EU	6171
rs6265^1,2	C,F,O,A,H,	other	73854021(-)	`AACACG/ATGATA`	34	/M /V	mis¹		39		MN NS EA NA EU	9503
rs3178739^1,2	C	--	27374789(-)	`TATTCA/CCCATG`	17	--	ut3¹ ese³		3		MN NA	188
rs80244532^1,2		--	27374956(+)	`GAACGA/GACACA`	17	--	ut3¹		0	--	--	--	--
rs41282914^1,2	C,F,	--	27375130(+)	`NNNNTG/AGGGGG`	17	--	ut3¹		1		NA	120
rs7124665^1,2	C,F,A,	--	27375233(+)	`acaaaG/Tataat`	17	--	ut3¹		1		WA	118
rs41282916^1,2	C,	--	27376349(+)	`TAGGTG/ATNNNN`	17	--	ut3¹		2		NA	122
rs116594815^1,2	C,F,	--	27376470(+)	`AATCTT/CCATTT`	17	--	ut3¹		1		WA	118
rs76327806^1,2	C,F,	--	27376557(+)	`CACAAT/CGTGTT`	17	--	ut3¹		3		WA CSA	122
rs77500722^1,2	F,	--	27376646(+)	`CAGAGG/CGGGAG`	17	--	ut3¹		1		EA	120

HapMap Linkage Disequilibrium report for BDNF (27676440 - 27743605 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BDNF
1 Indel: 58508
Human Gene Mutation Database (HGMD): BDNF

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BDNF for disorders           About GeneDecksing

OMIM gene information: 113505
OMIM disorders: 209880  164230  607499  606788
UniProtKB/Swiss-Prot: BDNF_HUMAN, P23560

Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as

congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of

respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in

autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia

and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in

about 16% of CCHS cases

20/176 diseases for BDNF (see all 176): About MalaCards

obsessive-compulsive disorder, protection against obsessive-compulsive disorder mood disorder bulimia nervosa, age of onset of weight loss in

attention deficit hyperactivity disorder central hypoventilation syndrome transient global amnesia memory impairment

bulimia nervosa spinal cord injury normal pressure hydrocephalus relapsing-remitting multiple sclerosis

cannabis abuse aids dementia complex anorexia nervosa status epilepticus

17 diseases from the University of Copenhagen DISEASES database for BDNF:

Schizophrenia Alzheimer's disease Parkinson's disease Huntington's disease

Toxic encephalopathy Rett syndrome Cerebrovascular accident Amyotrophic lateral sclerosis

Autistic disorder Neuroblastoma Multiple sclerosis Glaucoma

Attention deficit hyperactivity disorder Brain ischemia Bipolar disorder Neuropathy

Anxiety disorder

10/91 Novoseek disease relationships for BDNF gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases	69.9	49	19498435 (2), 19748969 (2), 8197193 (1), 7523178 (1) (see all 39)
bipolar disorder	68.6	111	17012654 (5), 17464718 (5), 16568151 (4), 16388065 (3) (see all 60)
major depression	67.5	130	19371767 (4), 15291244 (4), 18406398 (4), 18329817 (3) (see all 62)
mood disorders	67.4	91	15145621 (5), 20013430 (5), 19473771 (4), 15626819 (3) (see all 56)
schizophrenia	62	269	19368899 (8), 19720106 (6), 15276697 (6), 17464718 (5) (see all 99)
alzheimers disease	61.4	109	12456067 (3), 12654514 (3), 12358753 (3), 16362629 (3) (see all 70)
huntington disease	61.3	39	19498435 (3), 18093249 (2), 17096834 (2), 17427191 (2) (see all 29)
neurodegeneration	54.9	24	10867782 (1), 17990049 (1), 19679106 (1), 15262269 (1) (see all 16)
rett syndrome	54.6	16	19349604 (3), 16996699 (2), 19096215 (1), 16446133 (1) (see all 12)
parkinson disease	53.2	68	15666411 (3), 8197193 (2), 17069877 (2), 11040419 (2) (see all 45)

Genetic Association Database (GAD): BDNF
Human Genome Epidemiology (HuGE) Navigator: BDNF (536 documents)

Export disorders for BDNF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BDNF gene, integrated from 9 sources (see all 2491):
(articles sorted by number of sources associating them with BDNF)

Utopia: connect your pdf to the dynamic
world of online information

Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PubMed id 1889806)^{1, 2, 3, 9} Maisonpierre P.C....Yancopoulos G.D. (1991)
Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. (PubMed id 12836135)^{1, 2, 4, 9} Hall D.... Karayiorgou M. (2003)
Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. (PubMed id 15115760)^{1, 2, 4} Ribases M.... Estivill X. (2004)
Molecular cloning of a human gene that is a member of the nerve growth factor family. (PubMed id 2236018)^{1, 2, 3} Jones K.R. and Reichardt L.F. (1990)
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. (PubMed id 15899246)^{1, 4, 9} Lee J....Ingelsson M. (2005)
Brain-derived neurotrophic factor and obesity in the WAGR syndrome. (PubMed id 18753648)^{1, 2, 9} Han J.C.... Yanovski J.A. (2008)
Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease. (PubMed id 15726264)^{1, 4, 9} Vepsalainen S....Hiltunen M. (2005)
BDNF gene is a risk factor for schizophrenia in a Scottish population. (PubMed id 15630410)^{1, 4, 9} Neves-Pereira M....St Clair D.M. (2005)
No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia. (PubMed id 15949651)^{1, 4, 9} Szczepankiewicz A....Hauser J. (2005)
BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorder. (PubMed id 15626819)^{1, 4, 9} Strauss J....Kennedy J.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 627	HGNC: 1033	AceView: BDNF.1	Ensembl:ENSG00000176697	euGenes: HUgn627
ECgene: BDNF	Kegg: 627	H-InvDB: BDNF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BDNF	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor

Intellectual Property for BDNF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BDNF gene:
Search GeneIP for patents involving BDNF

GeneCards and IP:
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In Situ Hybridization Assays from
Advanced Cell Diagnostics
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brain-derived neurotrophic factor

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