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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BDKRB2 Gene

protein-coding GIFtS: 66
GCID: GC14P096671

bradykinin receptor B2

Explore 55 diseases affiliated with
BDKRB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bradykinin Receptor B2¹ ²		BK-2 Receptor² ³
BK-2¹ ²		BK2²
B2R² ³		BRB2²
BKR2² ³		B2 Bradykinin Receptor²

External Ids:	HGNC: 1030¹	Entrez Gene: 624²	Ensembl: ENSG00000168398⁷	OMIM: 113503⁵	UniProtKB: P30411³

Export aliases for BDKRB2 gene to outside databases

Previous GC identifers: GC14P094182 GC14P090487 GC14P094661 GC14P095740 GC14P076856

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BDKRB2:

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation,

edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a

phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411

Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second

messenger system

summary for BDKRB2:

Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and

pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their

action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor.

Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation,

smooth muscle contraction and pain.

Gene Wiki entry for BDKRB2 (Bradykinin receptor B2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BDKRB2 gene promoter:
CREB deltaCREB Nkx2-5 STAT1alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BDKRB2 promoter sequence

Search SABiosciences Chromatin IP Primers for BDKRB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BDKRB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1-q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.1-q32.2

BDKRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDKRB2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P096671: view genomic region (about GC identifiers)

Start:	96,671,016 bp from pter	End:	96,710,666 bp from pter
Size:	39,651 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411 (See protein sequence)

Recommended Name: B2 bradykinin receptor

Size: 391 amino acids; 44461 Da

Subunit: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1

Subcellular location: Cell membrane; Multi-pass membrane protein

Alternative splicing: 2 isoforms: P30411-1 P30411-2

Explore the universe of human proteins at neXtProt for BDKRB2: NX_P30411

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30411

BDKRB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000614.1

ENSEMBL proteins:

ENSP00000439459 ENSP00000450482 ENSP00000438376 ENSP00000307713

Reactome Protein details: P30411
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant BDKRB2 Protein
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	Uscn Proteins for BDKRB2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	IDA	17077303
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	7916737

BDKRB2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BDKRB2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BDKRB2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001504 Brdyknn_2_rcpt

IPR000496 Brdyknn_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P30411

ProtoNet protein and cluster: P30411

2 Blocks protein families:

IPB000496 Bradykinin receptor signature

IPB001504 B2 bradykinin receptor signature

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411

Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411

Function: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second

messenger system

Genatlas biochemistry entry for BDKRB2:

bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor

superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD)

miRNA Products:		OriGene 3'-UTR Clone: BDKRB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BDKRB2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate BDKRB2:
		hsa-miR-885-3p hsa-miR-1827 hsa-miR-486-3p
		SwitchGear 3'UTR luciferase reporter plasmid: BDKRB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BDKRB2 (see all 7) OriGene shRNA RFP: BDKRB2 OriGene siRNA: BDKRB2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BDKRB2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	17077303
GO:0004435	phosphatidylinositol phospholipase C activity	TAS	8302267
GO:0004947	bradykinin receptor activity	IDA	17077303
GO:0005515	protein binding	IPI	18672896
GO:0031702	type 1 angiotensin receptor binding	IPI	10993080

BDKRB2 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for BDKRB2:

Decreased telomerase activity	G0/1 arrest	Increased G1 DNA content	Increased cell transformation
Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for BDKRB2: Bdkrb2^tm1Jfh Bdkrb2/Bdkrb1^{Bdkrb2/tm1Mki}
15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bdkrb2):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system	integument
mortality/aging	normal	renal/urinary system	reproductive system	skeleton

BDKRB2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	1.00			ACE Inhibitor Pathway	0.85
	ACE Inhibitor Pathway, Pharmacodynamics	1.00

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for BDKRB2

	Selected targets of CREB1
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
	Selected targets of p53

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BDKRB2

eNOS Signaling

5 BioSystems Pathways for BDKRB2

	ACE Inhibitor Pathway
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Direct p53 effectors
	Peptide GPCRs

5/9 Reactome Pathways for BDKRB2 (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

2 PharmGKB Pathways for BDKRB2

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

5/6 Kegg Pathways (Kegg details for BDKRB2) (see all 6):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeleton
	Endocrine and other factor-regulated calcium reabsorption

BDKRB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BDKRB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/261 Interacting proteins for BDKRB2 (P30411³ ENSP00000307713⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 261)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124³, ENSP00000340944⁴	I2D: score=3 STRING: ENSP00000340944
AGTR1	P30556³, ENSP00000273430⁴	I2D: score=2 STRING: ENSP00000273430
GRK6	P43250³, ENSP00000377204⁴	I2D: score=2 STRING: ENSP00000377204
NOS1	P29475³, ENSP00000320758⁴	I2D: score=2 STRING: ENSP00000320758
PRKCD	Q05655³, ENSP00000331602⁴	I2D: score=2 STRING: ENSP00000331602

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002438	acute inflammatory response to antigenic stimulus	--	--
GO:0006939	smooth muscle contraction	IC	17077303
GO:0006954	inflammatory response	IC	17077303
GO:0007166	cell surface receptor signaling pathway	TAS	7916737
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	10653985

BDKRB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BDKRB2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for BDKRB2 available from Tocris Bioscience About this table

Compound	Action	CAS #
HOE 140	Potent and selective B2 antagonist	[138614-30-9]
Bombinakinin M	Potent bradykinin receptor agonist	[509151-65-9]
Lys-Bradykinin	Potent bradykinin receptor agonist (B2 > B1)	[342-10-9]
WIN 64338 hydrochloride	Bradykinin B2 antagonist	[151039-63-3]
Bradykinin	Endogenous agonist at bradykinin receptors (B2 > B1)	[6846-03-3]

2 HMDB Compounds for BDKRB2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Bradykinin	Callidin I (see all 5)	58-82-2	--
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for BDKRB2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Icatibant	--	130308-48-4	target	antagonist	14514033 11752352

10/63 Novoseek chemical compound relationships for BDKRB2 gene (see all 63) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
icatibant	91.5	26	8813637 (2), 10219847 (2), 11104833 (2), 9786500 (1) (see all 23)
fr190997	89.8	6	9647466 (1), 15140628 (1), 9224807 (1), 10615010 (1) (see all 6)
des-arg(10)-kallidin	86.9	2	18187413 (1), 11379050 (1)
fr173657	86.1	5	11104833 (2), 9051299 (1), 10204994 (1), 9203620 (1)
kallidin	85.3	6	10419551 (2), 18187413 (1), 8856153 (1), 11379050 (1)
cereport	82.2	8	19439100 (3), 11286321 (2), 10362103 (1), 11550318 (1)
anatibant	78.8	4	19958523 (2), 19958522 (2), 16379582 (1), 19958521 (1)
kininogen	65.2	6	19725054 (1), 18187413 (1), 16272198 (1), 15375773 (1) (see all 5)
enalaprilat	54.5	2	7853175 (1), 8953504 (1)
captopril	53.3	8	9383175 (1), 12424228 (1), 8953933 (1), 8389325 (1) (see all 7)

1 PharmGKB related drug/compound annotation for BDKRB2 gene

Drug/compound	PharmGKB Annotation
"Ace Inhibitors, Plain"	CA

About this table

Search CenterWatch for drugs/clinical trials and news about BDKRB2 / BKRB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BDKRB2 gene:

NM_000623.3

Unigene Clusters for BDKRB2:

Bradykinin receptor B2

Hs.654542 [show with all ESTs], Hs.726620 [show with all ESTs]

Unigene Representative Sequences: CR749338, NM_000623

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000542454(uc010avl.2 uc010twu.1) ENST00000554311 ENST00000539359

ENST00000306005(uc010avm.1 uc001yfg.2)

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		hsa-miR-885-3p hsa-miR-1827 hsa-miR-486-3p
		SwitchGear 3'UTR luciferase reporter plasmid: BDKRB2 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BDKRB2

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		GenScript: all cDNA clones in your preferred vector: BDKRB2 (NM_000623)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BDKRB2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BDKRB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BDKRB2

8 DOTS entries:

DT.95369242 DT.110466 DT.95235331 DT.91849441 DT.92431959 DT.95369243 DT.92431960 DT.120783283

24/87 AceView cDNA sequences (see all 87):

NM_000710 CD216772 BC074894 AW239080 BC074895 CA430240 AI095360 BU540691

AI803477 AY275465 AI742135 AJ238044 CA432819 BQ024471 X86165 AI242364

BQ917469 BQ014905 AU142100 BM823930 CB151921 BF057849 AI168004 U12512

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BDKRB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTTTTCT

About this image

BDKRB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BDKRB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BDKRB2

SOURCE GeneReport for Unigene clusters: Hs.654542 Hs.726620

UniProtKB/Swiss-Prot: BKRB2_HUMAN, P30411

Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons

SABiosciences Expression via Pathway-Focused PCR Arrays including BDKRB2:

G Protein Coupled Receptors 384HT in human mouse rat

Hypertension in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BDKRB2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BDKRB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB2 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BDKRB2¹	bradykinin receptor B2	63.02(n) 56.84(a)		428906 NM_001031553.1 NP_001026724.1
lizard (Anolis carolinensis)	Reptilia	BDKRB2⁶	--	52(a)	1 ↔ 1	1(7747242-7748551)
zebrafish (Danio rerio)	Actinopterygii	LOC100330960¹	b2 bradykinin receptor-like	55.25(n) 46.67(a)		100330960 XM_002665091.1 XP_002665137.1

ENSEMBL Gene Tree for BDKRB2 (if available)
TreeFam Gene Tree for BDKRB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BDKRB2 gene

RXFP3² BDKRB1² AGTR2² AGTR1² GPR25² CXCR7² APLNR² GPR15²

RXFP4² GPR182²

18/20 SIMAP similar genes for BDKRB2 using alignment to 2 protein entries: BKRB2_HUMAN (see all proteins) (see all similar genes):

DKFZp686O088 CCR8 CCR1 BDKRB1 CX3CR1 CCR2

CCR4 CXCR1 AGTR2 CXCR2 IL8RB AGTR1

CCR5 CCR3 APLNR CCR9 CCRL1 CXCR3

BDKRB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113562942^1,2		--	96669157(+)	`CAGACG/AGATGG`	1	--	us2k¹		3		CSA WA NA	240
rs28605743^1,2		--	96669180(+)	`ATGGAC/TGGACA`	1	--	us2k¹		3		NA WA	122
rs192188916^1,2		--	96669207(+)	`GATGGA/TTGGAT`	1	--	us2k¹		0	--	--	--	--
rs184028677^1,2		--	96669240(+)	`ACAGGC/TGAATA`	1	--	us2k¹		0	--	--	--	--
rs138875497^1,2		--	96669241(+)	`CAGGCA/GAATAA`	1	--	us2k¹		0	--	--	--	--
rs189932652^1,2		--	96669285(+)	`TGGGCA/GGATGT`	1	--	us2k¹		0	--	--	--	--
rs142800824^1,2		--	96669344(+)	`TAAGAC/TTAAAA`	1	--	us2k¹		0	--	--	--	--
rs4144131^1,2	C,F,A,H,	--	96669401(-)	`GTTCTA/GCCTTT`	1	--	us2k¹		23		NS EA NA CSA WA	2763
rs192761744^1,2		--	96669403(+)	`AGGTAA/GAACTT`	1	--	us2k¹		0	--	--	--	--
rs115806677^1,2	F,	--	96669466(+)	`TGCAAC/GTGGGG`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for BDKRB2 (96671016 - 96710666 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for BDKRB2
5 CNVs: 87335 49450 49451 53371 49449
Human Gene Mutation Database (HGMD): BDKRB2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BDKRB2 for disorders           About GeneDecksing

OMIM gene information: 113503    OMIM disorders: --

20/55 diseases for BDKRB2 (see all 55):    About MalaCards

placenta accreta acute mountain sickness interleukin receptor angioedema

traumatic brain injury myocardial infarction brain edema brain injury

chronic obstructive pulmonary disease hereditary angioedema essential hypertension acute myocardial infarction

allergic rhinitis polycystic kidney disease portal hypertension inflammatory bowel disease

ulcerative colitis insulin resistance kidney disease rhinitis

10/33 Novoseek disease relationships for BDKRB2 gene (see all 33) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
angioedema, hereditary	62	3	19758369 (2), 17073887 (1)
inflammation	37	13	9228537 (1), 16740128 (1), 20036002 (1), 9786513 (1) (see all 11)
angioedema	36.8	1	20461661 (1)
brain edema	34.5	2	14534854 (1), 14753436 (1)
glioma	19.1	7	12500695 (3), 8906560 (1), 9009737 (1), 16455538 (1)
reactive hyperemia	16.2	1	9054837 (1)
essential hypertension	14.5	3	15643125 (1), 15894833 (1), 18803964 (1)
diabetic nephropathies	14.3	5	15934924 (2), 16555685 (2), 15326315 (1)
airways disease	12.7	1	16455073 (1)
brain tumors	11.5	6	19439100 (2), 9525816 (1), 12500695 (1), 17359538 (1) (see all 5)

Genetic Association Database (GAD): BDKRB2
Human Genome Epidemiology (HuGE) Navigator: BDKRB2 (60 documents)

Export disorders for BDKRB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BDKRB2 gene, integrated from 9 sources (see all 391):
(articles sorted by number of sources associating them with BDKRB2)

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Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PubMed id 7916737)^{1, 2, 3, 9} Powell S.J.... Graham A. (1993)
Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. (PubMed id 15894833)^{1, 4, 9} Fu Y....Ogihara T. (2004)
Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. (PubMed id 12522467)^{1, 4, 9} Mukae S....Katagiri T. (2002)
Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. (PubMed id 7835885)^{1, 2, 9} Ma J.-X.... Chao L. (1994)
Association of the human bradykinin B2 receptor gene with chronic renal failure. (PubMed id 15771553)^{1, 4, 9} Jozwiak L....Buraczynska M. (2004)
Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. (PubMed id 1314587)^{1, 2, 9} Hess J.F.R.... Ransom R.W. (1992)
Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PubMed id 15643125)^{1, 4, 9} Cui J....Gavras H. (2005)
Rapid and reliable genotyping of the C181T polymorphism in the bradykinin B2 receptor gene. (PubMed id 12705334)^{1, 4, 9} Weiss J....Haefeli W.E. (2003)
Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. (PubMed id 14499231)^{1, 4, 9} Dhamrait S.S....Montgomery H.E. (2003)
Bradykinin B2 receptor gene polymorphism is associated with altered urinary albumin/creatinine values in diabetic patients. (PubMed id 12025967)^{1, 4, 9} Maltais I....Bachvarov D. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 624	HGNC: 1030	AceView: BDKRB2	Ensembl:ENSG00000168398	euGenes: HUgn624
ECgene: BDKRB2	Kegg: 624	H-InvDB: BDKRB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BDKRB2	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Bradykinin_receptor
SeattleSNPs	http://pga.gs.washington.edu/data/bdkrb2/

Intellectual Property for BDKRB2 gene
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Patent Information for BDKRB2 gene:
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bradykinin receptor B2

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