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Aliases for BDKRB2 Gene

Aliases for BDKRB2 Gene

  • Bradykinin Receptor B2 2 3
  • BK-2 Receptor 3 4
  • BKR2 3 4
  • B2R 3 4
  • B2 Bradykinin Receptor 3
  • BK-2 3
  • BRB2 3
  • BK2 3

External Ids for BDKRB2 Gene

Previous GeneCards Identifiers for BDKRB2 Gene

  • GC14P094182
  • GC14P090487
  • GC14P094661
  • GC14P095740
  • GC14P096671
  • GC14P076856

Summaries for BDKRB2 Gene

Entrez Gene Summary for BDKRB2 Gene

  • This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for BDKRB2 Gene

BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include acute mountain sickness and placenta accreta. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include protein heterodimerization activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for BDKRB2 Gene

  • Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for BDKRB2 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.

Gene Wiki entry for BDKRB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB2 Gene

Genomics for BDKRB2 Gene

Regulatory Elements for BDKRB2 Gene

Genomic Location for BDKRB2 Gene

96,204,679 bp from pter
96,244,329 bp from pter
39,651 bases
Plus strand

Genomic View for BDKRB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BDKRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDKRB2 Gene

Proteins for BDKRB2 Gene

  • Protein details for BDKRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B2 bradykinin receptor
    Protein Accession:
    Secondary Accessions:

    Protein attributes for BDKRB2 Gene

    391 amino acids
    Molecular mass:
    44461 Da
    Quaternary structure:
    • Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.

    Alternative splice isoforms for BDKRB2 Gene


neXtProt entry for BDKRB2 Gene

Proteomics data for BDKRB2 Gene at MOPED

Post-translational modifications for BDKRB2 Gene

  • Glycosylation at Asn30, Asn39, and Asn207
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BDKRB2 Gene

Domains for BDKRB2 Gene

Gene Families for BDKRB2 Gene

Suggested Antigen Peptide Sequences for BDKRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
genes like me logo Genes that share domains with BDKRB2: view

Function for BDKRB2 Gene

Molecular function for BDKRB2 Gene

GENATLAS Biochemistry:
bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD)
UniProtKB/Swiss-Prot Function:
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 17077303
GO:0004435 phosphatidylinositol phospholipase C activity TAS 8302267
GO:0004930 G-protein coupled receptor activity --
GO:0004947 bradykinin receptor activity IDA 17077303
GO:0005515 protein binding IPI 18672896
genes like me logo Genes that share ontologies with BDKRB2: view
genes like me logo Genes that share phenotypes with BDKRB2: view

Animal Models for BDKRB2 Gene

MGI Knock Outs for BDKRB2:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BDKRB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for BDKRB2 Gene

Localization for BDKRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BDKRB2 Gene COMPARTMENTS Subcellular localization image for BDKRB2 gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2

Gene Ontology (GO) - Cellular Components for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 17077303
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7916737
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with BDKRB2: view

Pathways for BDKRB2 Gene

genes like me logo Genes that share pathways with BDKRB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for BDKRB2 Gene

Selected Interacting proteins: P30411-BKRB2_HUMAN for BDKRB2 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IC 17077303
GO:0006954 inflammatory response IC 17077303
GO:0007166 cell surface receptor signaling pathway TAS 7916737
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 10653985
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with BDKRB2: view

Drugs for BDKRB2 Gene

(1) Drugbank Compounds for BDKRB2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • HOE 140
130308-48-4 71364 Target antagonist approved

(5) Tocris Compounds for BDKRB2 Gene

Compound Action Cas Number
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) [58-82-2]
HOE 140 Potent and selective B2 antagonist [130308-48-4]
Lys-[Des-Arg9]Bradykinin Selective B1 agonist [71800-36-7]
MEN 11270 Selective B2 antagonist; analog of HOE 140 (Cat. No. 3014) [235082-52-7]
Sar-[D-Phe8]-des-Arg9-Bradykinin Potent and selective B1 agonist [126959-88-4]

(3) HMDB Compounds for BDKRB2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Callidin I
  • Ca
  • JE049

(25) IUPHAR Ligand for BDKRB2 Gene

Ligand Type Action Affinity Pubmed IDs
B-9430 Antagonist Antagonist 9.6
[3H]NPC17731 Antagonist Antagonist 9.4
icatibant Antagonist Antagonist 9.4
kallidin Agonist Full agonist 9.3
bradykinin Agonist Full agonist 9.3
FR191413 Agonist Full agonist 9.2
JMV1116 Agonist Full agonist 9.2
Met-Lys-bradykinin Agonist Full agonist 8.7
JMV1431 Antagonist Antagonist 8.4
anatibant Antagonist Antagonist 8.2
FR173657 Antagonist Antagonist 8.1
NPC 17731 Antagonist Antagonist 8.1
[Tyr8]bradykinin Agonist Full agonist 8
FR190997 Agonist Full agonist 7.3
FR167344 Antagonist Antagonist 7.2
WIN 64338 Antagonist Antagonist 7.2
NPC-349 Antagonist Antagonist 7
NPC-567 Antagonist Antagonist 6.9
NPC 18565 Antagonist Antagonist 6.6
bradyzide Antagonist Antagonist 6.5
[Thi5,8,D-Phe7]bradykinin Antagonist Antagonist 6.3
[des-Arg9]bradykinin Agonist Full agonist 5.1
[Hyp3,Tyr(Me)8]BK Agonist Full agonist
[125I][Tyr8]bradykinin None None
[Phe8,psi(CH2-NH)Arg9]BK Agonist Full agonist

(63) Novoseek inferred chemical compound relationships for BDKRB2 Gene

Compound -log(P) Hits PubMed IDs
icatibant 91.5 26
fr190997 89.8 6
des-arg(10)-kallidin 86.9 2
fr173657 86.1 5
kallidin 85.3 5

(4) PharmGKB related drug/compound annotations for BDKRB2 Gene

genes like me logo Genes that share compounds with BDKRB2: view

Transcripts for BDKRB2 Gene

mRNA/cDNA for BDKRB2 Gene

Unigene Clusters for BDKRB2 Gene

Bradykinin receptor B2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BDKRB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB2 Gene

No ASD Table

Relevant External Links for BDKRB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BDKRB2 Gene

mRNA expression in normal human tissues for BDKRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BDKRB2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for BDKRB2 Gene

SOURCE GeneReport for Unigene cluster for BDKRB2 Gene Hs.654542

mRNA Expression by UniProt/SwissProt for BDKRB2 Gene

Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
genes like me logo Genes that share expressions with BDKRB2: view

Expression partners for BDKRB2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BDKRB2 Gene

Orthologs for BDKRB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BDKRB2 35
  • 85.68 (n)
  • 81.51 (a)
  • 80 (a)
(Canis familiaris)
Mammalia BDKRB2 35
  • 87.09 (n)
  • 81.03 (a)
  • 80 (a)
(Mus musculus)
Mammalia Bdkrb2 35
  • 83.25 (n)
  • 80.83 (a)
Bdkrb2 16
Bdkrb2 36
  • 80 (a)
(Pan troglodytes)
Mammalia BDKRB2 35
  • 99.32 (n)
  • 99.49 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Bdkrb2 35
  • 81.97 (n)
  • 78.97 (a)
(Monodelphis domestica)
Mammalia BDKRB2 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia BDKRB2 36
  • 66 (a)
(Gallus gallus)
Aves BDKRB2 35
  • 62.55 (n)
  • 56.63 (a)
  • 51 (a)
(Anolis carolinensis)
Reptilia BDKRB2 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bdkrb2 35
  • 59.88 (n)
  • 54.87 (a)
(Danio rerio)
Actinopterygii LOC100330960 35
  • 55.42 (n)
  • 47.29 (a)
BDKRB2 (1 of 2) 36
  • 38 (a)
CABZ01058422.1 36
  • 44 (a)
Species with no ortholog for BDKRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB2 Gene

Gene Tree for BDKRB2 (if available)
Gene Tree for BDKRB2 (if available)

Paralogs for BDKRB2 Gene

Paralogs for BDKRB2 Gene

(20) SIMAP similar genes for BDKRB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BDKRB2: view

Variants for BDKRB2 Gene

Sequence variations from dbSNP and Humsavar for BDKRB2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs5223 -- 96,204,885(+) GGTGG(G/T)GACGG utr-variant-5-prime
rs5224 -- 96,241,120(+) CAGAC(A/G)GAGAG reference, synonymous-codon
rs5225 -- 96,241,886(+) AGAAC(C/T)GCCAT utr-variant-3-prime
rs5226 -- 96,242,206(+) GGAAC(A/G)ACTGG utr-variant-3-prime
rs871547 -- 96,238,024(+) CAAGG(C/G/T)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BDKRB2 Gene

Variant ID Type Subtype PubMed ID
nsv1416 CNV Insertion 18451855
nsv515629 CNV Loss 19592680
dgv262n27 CNV Loss 19166990
esv1004672 CNV Insertion 20482838

Relevant External Links for BDKRB2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDKRB2 Gene

Disorders for BDKRB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BDKRB2 Gene in MalaCards »

(4) Diseases for BDKRB2 Gene

(33) Novoseek inferred disease relationships for BDKRB2 Gene

Disease -log(P) Hits PubMed IDs
angioedema, hereditary 62 3
inflammation 37 11
angioedema 36.8 1
brain edema 34.5 2
glioma 19.1 6

Relevant External Links for BDKRB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BDKRB2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for BDKRB2 Gene

Publications for BDKRB2 Gene

  1. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PMID: 7916737) Powell S.J. … Graham A. (Genomics 1993) 2 3 4 23
  2. Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. (PMID: 1314587) Hess J.F.R. … Ransom R.W. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  3. Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. (PMID: 7835885) Ma J.-X. … Chao L. (Genomics 1994) 3 4 23
  4. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. (PMID: 12522467) Mukae S. … Katagiri T. (J Hum Hypertens 2002) 3 23 48
  5. The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons. (PMID: 16461337) Saunders C.J. … Collins M. (Hum. Mol. Genet. 2006) 3 23 48

Products for BDKRB2 Gene

Sources for BDKRB2 Gene

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