Aliases for BDKRB2 Gene
External Ids for BDKRB2 Gene
Previous GeneCards Identifiers for BDKRB2 Gene
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for BDKRB2 Gene
BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include acute mountain sickness and placenta accreta. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include protein heterodimerization activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is ACKR3.
UniProtKB/Swiss-Prot for BDKRB2 Gene
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system
Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.