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Aliases for BDKRB2 Gene

Aliases for BDKRB2 Gene

  • Bradykinin Receptor B2 2 3 5
  • BK-2 Receptor 3 4
  • BKR2 3 4
  • B2R 3 4
  • B2 Bradykinin Receptor 3
  • BK-2 3
  • BRB2 3
  • BK2 3

External Ids for BDKRB2 Gene

Previous GeneCards Identifiers for BDKRB2 Gene

  • GC14P094182
  • GC14P090487
  • GC14P094661
  • GC14P095740
  • GC14P096671
  • GC14P076856

Summaries for BDKRB2 Gene

Entrez Gene Summary for BDKRB2 Gene

  • This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for BDKRB2 Gene

BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include Brain Edema and Angioedema, Hereditary, Types I And Ii. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protease binding. An important paralog of this gene is BDKRB1.

UniProtKB/Swiss-Prot for BDKRB2 Gene

  • Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for BDKRB2 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Gene Wiki entry for BDKRB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB2 Gene

Genomics for BDKRB2 Gene

Regulatory Elements for BDKRB2 Gene

Enhancers for BDKRB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F096100 1.5 FANTOM5 Ensembl ENCODE 14.1 -100.7 -100655 7.7 PKNOX1 SIN3A ZNF2 YY1 ZNF121 ZNF143 FOS ZNF263 ZHX2 REST BDKRB2 C14orf132 BDKRB1
GH14F096245 1.1 Ensembl ENCODE 17.9 +42.1 42144 2.3 GTF2F1 TBP CTCF MXI1 JUN INSM2 KLF17 MAX RAD21 RFX5 BDKRB2 GSKIP ENSG00000258793 PIR41586 ENSG00000259036
GH14F096094 1.2 Ensembl ENCODE 10.6 -108.5 -108469 3.7 SIN3A RAD21 RARA YY1 ZNF121 RCOR1 FOS MIXL1 ZHX2 CEBPB BDKRB2 C14orf132
GH14F096260 0.8 ENCODE 13.6 +57.4 57400 3.7 GTF2F1 CTCF MXI1 ESRRA MAX RAD21 ZIC2 ZBTB40 ZNF664 GATA3 BDKRB2 ATG2B PAPOLA ENSG00000258793 GC14M096266 BDKRB1
GH14F096264 1 Ensembl ENCODE 9.2 +62.8 62849 5.3 CTCF MAX ZIC2 RAD21 ZNF121 ZNF664 SMC3 NR2F6 ZNF600 PRDM10 ENSG00000258793 BDKRB2 PAPOLA GSKIP BDKRB1 GC14M096266
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BDKRB2 on UCSC Golden Path with GeneCards custom track

Promoters for BDKRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000423295 421 1401 ELF3 PKNOX1 ZNF76 KLF17 SIN3A FEZF1 GLIS2 ZNF366 EGR2 CEBPB

Genomic Location for BDKRB2 Gene

Chromosome:
14
Start:
96,204,679 bp from pter
End:
96,244,329 bp from pter
Size:
39,651 bases
Orientation:
Plus strand

Genomic View for BDKRB2 Gene

Genes around BDKRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BDKRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BDKRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDKRB2 Gene

Proteins for BDKRB2 Gene

  • Protein details for BDKRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30411-BKRB2_HUMAN
    Recommended name:
    B2 bradykinin receptor
    Protein Accession:
    P30411

    Protein attributes for BDKRB2 Gene

    Size:
    391 amino acids
    Molecular mass:
    44461 Da
    Quaternary structure:
    • Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.

    Alternative splice isoforms for BDKRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BDKRB2 Gene

Post-translational modifications for BDKRB2 Gene

  • Glycosylation at Asn 30, Asn 39, and Asn 207
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for BDKRB2

No data available for DME Specific Peptides for BDKRB2 Gene

Domains & Families for BDKRB2 Gene

Gene Families for BDKRB2 Gene

Suggested Antigen Peptide Sequences for BDKRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30411

UniProtKB/Swiss-Prot:

BKRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
genes like me logo Genes that share domains with BDKRB2: view

Function for BDKRB2 Gene

Molecular function for BDKRB2 Gene

GENATLAS Biochemistry:
bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD)
UniProtKB/Swiss-Prot Function:
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 17077303
GO:0004435 phosphatidylinositol phospholipase C activity TAS 8302267
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004947 bradykinin receptor activity IDA,TAS 17077303
genes like me logo Genes that share ontologies with BDKRB2: view
genes like me logo Genes that share phenotypes with BDKRB2: view

Animal Models for BDKRB2 Gene

MGI Knock Outs for BDKRB2:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for BDKRB2 (Bradykinin RB2/BDKRB2)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BDKRB2 Gene

Localization for BDKRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BDKRB2 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 17077303
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 7916737
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BDKRB2: view

Pathways & Interactions for BDKRB2 Gene

genes like me logo Genes that share pathways with BDKRB2: view

Interacting Proteins for BDKRB2 Gene

SIGNOR curated interactions for BDKRB2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IC 17077303
GO:0006950 response to stress IEA --
GO:0006954 inflammatory response IC 17077303
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 7916737
genes like me logo Genes that share ontologies with BDKRB2: view

Drugs & Compounds for BDKRB2 Gene

(74) Drugs for BDKRB2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icatibant Approved Pharma Antagonist, antagonist, Target 17
Lisinopril Approved, Investigational Pharma ACE inhibitor 118
Enalapril Approved, Vet_approved Pharma 120
Anatibant Investigational Pharma Antagonist, antagonist, Target 0
Bradykinin Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 50

(25) Additional Compounds for BDKRB2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Phe<sup>8</sup>,<i>psi</i>(CH<sub>2</sub>-NH)Arg<sup>9</sup>]BK
Full agonist, Agonist
[Phe8psi(CH-NH)-Arg9]-Bradykinin
118122-39-7

(5) Tocris Compounds for BDKRB2 Gene

Compound Action Cas Number
[Phe8psi(CH-NH)-Arg9]-Bradykinin Selective B2 agonist 118122-39-7
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) 58-82-2
HOE 140 Potent and selective B2 antagonist 130308-48-4
Lys-[Des-Arg9]Bradykinin Selective B1 agonist 71800-36-7
R 715 Potent and selective B1 antagonist 185052-09-9

(11) ApexBio Compounds for BDKRB2 Gene

Compound Action Cas Number
[Phe8Ψ(CH-NH)-Arg9]-Bradykinin 118122-39-7
Bombinakinin M 509151-65-9
Bombinakinin-GAP 573671-91-7
HOE 140 130308-48-4
Lys-[Des-Arg9]Bradykinin 71800-36-7
Lys-Bradykinin 342-10-9
MEN 11270 235082-52-7
R 715 185052-09-9
R 892 229030-05-1
Sar-[D-Phe8]-des-Arg9-Bradykinin 126959-88-4
WIN 64338 hydrochloride bradykinin B2 receptor antagonist, competitive 163727-74-0
genes like me logo Genes that share compounds with BDKRB2: view

Drug Products

Transcripts for BDKRB2 Gene

mRNA/cDNA for BDKRB2 Gene

Unigene Clusters for BDKRB2 Gene

Bradykinin receptor B2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for BDKRB2 (Bradykinin RB2/BDKRB2)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB2 Gene

No ASD Table

Relevant External Links for BDKRB2 Gene

GeneLoc Exon Structure for
BDKRB2
ECgene alternative splicing isoforms for
BDKRB2

Expression for BDKRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BDKRB2 Gene

Protein differential expression in normal tissues from HIPED for BDKRB2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BDKRB2 Gene



Protein tissue co-expression partners for BDKRB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BDKRB2 Gene:

BDKRB2

SOURCE GeneReport for Unigene cluster for BDKRB2 Gene:

Hs.654542

mRNA Expression by UniProt/SwissProt for BDKRB2 Gene:

P30411-BKRB2_HUMAN
Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
genes like me logo Genes that share expression patterns with BDKRB2: view

Primer Products

No data available for mRNA differential expression in normal tissues for BDKRB2 Gene

Orthologs for BDKRB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BDKRB2 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia BDKRB2 34 35
  • 87.09 (n)
cow
(Bos Taurus)
Mammalia BDKRB2 34 35
  • 85.68 (n)
mouse
(Mus musculus)
Mammalia Bdkrb2 34 16 35
  • 83.25 (n)
rat
(Rattus norvegicus)
Mammalia Bdkrb2 34
  • 81.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BDKRB2 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BDKRB2 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves BDKRB2 34 35
  • 62.55 (n)
lizard
(Anolis carolinensis)
Reptilia BDKRB2 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bdkrb2 34
  • 59.88 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330960 34
  • 55.42 (n)
CABZ01058422.1 35
  • 44 (a)
OneToMany
BDKRB2 (1 of 2) 35
  • 38 (a)
OneToMany
Species where no ortholog for BDKRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB2 Gene

ENSEMBL:
Gene Tree for BDKRB2 (if available)
TreeFam:
Gene Tree for BDKRB2 (if available)

Paralogs for BDKRB2 Gene

Paralogs for BDKRB2 Gene

(20) SIMAP similar genes for BDKRB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BDKRB2: view

Variants for BDKRB2 Gene

Sequence variations from dbSNP and Humsavar for BDKRB2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10130005 -- 96,234,643(+) TTCCT(C/T)AACCC intron-variant
rs10132462 -- 96,218,017(+) AGCCT(C/T)AGTTC intron-variant
rs10139406 -- 96,234,116(+) ATGCA(C/T)TCATC intron-variant
rs10143380 -- 96,229,828(+) ttaaa(C/T)tgaaa intron-variant
rs10145126 -- 96,227,546(+) ACACA(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BDKRB2 Gene

Variant ID Type Subtype PubMed ID
nsv983853 CNV duplication 23825009
nsv565647 CNV loss 21841781
nsv515629 CNV loss 19592680
nsv1416 CNV insertion 18451855
nsv1051786 CNV gain 25217958
esv3635420 CNV gain 21293372
esv3635419 CNV loss 21293372
esv3635418 CNV gain 21293372
esv3635417 CNV gain 21293372
esv1004672 CNV insertion 20482838
dgv262n27 CNV loss 19166990

Variation tolerance for BDKRB2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BDKRB2 Gene

Human Gene Mutation Database (HGMD)
BDKRB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BDKRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDKRB2 Gene

Disorders for BDKRB2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for BDKRB2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain edema
  • intracranial swelling
angioedema, hereditary, types i and ii
  • angioedema, hereditary, type i
angioedema
  • angioneurotic edema
c1 inhibitor deficiency
  • quincke edema
acute mountain sickness
  • altitude anoxia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BDKRB2

Genetic Association Database (GAD)
BDKRB2
Human Genome Epidemiology (HuGE) Navigator
BDKRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BDKRB2
genes like me logo Genes that share disorders with BDKRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BDKRB2 Gene

Publications for BDKRB2 Gene

  1. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PMID: 7916737) Powell S.J. … Graham A. (Genomics 1993) 2 3 4 22 64
  2. The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons. (PMID: 16461337) Saunders C.J. … Collins M. (Hum. Mol. Genet. 2006) 3 22 46 64
  3. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PMID: 15643125) Cui J. … Gavras H. (J. Hypertens. 2005) 3 22 46 64
  4. Association of the human bradykinin B2 receptor gene with chronic renal failure. (PMID: 15771553) Jozwiak L. … Buraczynska M. (Mol. Diagn. 2004) 3 22 46 64
  5. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. (PMID: 15894833) Fu Y. … Ogihara T. (Hypertens. Res. 2004) 3 22 46 64

Products for BDKRB2 Gene

Sources for BDKRB2 Gene

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