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Aliases for BDKRB1 Gene

Aliases for BDKRB1 Gene

  • Bradykinin Receptor B1 2 3 5
  • BK-1 Receptor 3 4
  • BRADYB1 3 4
  • B1R 3 4
  • B1 Bradykinin Receptor 3
  • Bradykinin B1 Receptor 3
  • Bradykinin Receptor B2 3
  • Bradykinin Receptor 1 3
  • BDKRB2 3
  • B1BKR 3
  • BKB1R 3
  • BKR1 3

External Ids for BDKRB1 Gene

Previous GeneCards Identifiers for BDKRB1 Gene

  • GC14P094233
  • GC14P090539
  • GC14P094712
  • GC14P095792
  • GC14P096722
  • GC14P076907

Summaries for BDKRB1 Gene

Entrez Gene Summary for BDKRB1 Gene

  • Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for BDKRB1 Gene

BDKRB1 (Bradykinin Receptor B1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity and bradykinin receptor activity. An important paralog of this gene is BDKRB2.

UniProtKB/Swiss-Prot for BDKRB1 Gene

  • This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Tocris Summary for BDKRB1 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Gene Wiki entry for BDKRB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB1 Gene

Genomics for BDKRB1 Gene

Regulatory Elements for BDKRB1 Gene

Enhancers for BDKRB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BDKRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BDKRB1 Gene

Chromosome:
14
Start:
96,255,824 bp from pter
End:
96,268,967 bp from pter
Size:
13,144 bases
Orientation:
Plus strand

Genomic View for BDKRB1 Gene

Genes around BDKRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BDKRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BDKRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDKRB1 Gene

Proteins for BDKRB1 Gene

  • Protein details for BDKRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46663-BKRB1_HUMAN
    Recommended name:
    B1 bradykinin receptor
    Protein Accession:
    P46663
    Secondary Accessions:
    • A8K7F5
    • Q546S7
    • Q8N0Y8

    Protein attributes for BDKRB1 Gene

    Size:
    353 amino acids
    Molecular mass:
    40495 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BDKRB1 Gene

Post-translational modifications for BDKRB1 Gene

  • Glycosylation at Asn 14, Asn 22, and Asn 185
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BDKRB1 Gene

Domains & Families for BDKRB1 Gene

Gene Families for BDKRB1 Gene

Suggested Antigen Peptide Sequences for BDKRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46663

UniProtKB/Swiss-Prot:

BKRB1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
genes like me logo Genes that share domains with BDKRB1: view

Function for BDKRB1 Gene

Molecular function for BDKRB1 Gene

GENATLAS Biochemistry:
bradykinin B1 receptor,selectively sensible to fragments of kinins,lacking the Cter Arg,G protein coupled receptor superfamily,putatively exercying protective role in the end stage renal disease (ESRD)
UniProtKB/Swiss-Prot Function:
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Gene Ontology (GO) - Molecular Function for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004947 bradykinin receptor activity IEA --
GO:0005515 protein binding IPI 23597562
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with BDKRB1: view
genes like me logo Genes that share phenotypes with BDKRB1: view

Animal Models for BDKRB1 Gene

MGI Knock Outs for BDKRB1:

Animal Model Products

CRISPR Products

miRNA for BDKRB1 Gene

miRTarBase miRNAs that target BDKRB1

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for BDKRB1 (Bradykinin RB1/BDKRB1)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BDKRB1 Gene

Localization for BDKRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BDKRB1 Gene COMPARTMENTS Subcellular localization image for BDKRB1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
endoplasmic reticulum 4
nucleus 1

Gene Ontology (GO) - Cellular Components for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9930991
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8063797
GO:0016020 membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with BDKRB1: view

Pathways & Interactions for BDKRB1 Gene

genes like me logo Genes that share pathways with BDKRB1: view

Gene Ontology (GO) - Biological Process for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006954 inflammatory response IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 8063797
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with BDKRB1: view

No data available for SIGNOR curated interactions for BDKRB1 Gene

Drugs & Compounds for BDKRB1 Gene

(58) Drugs for BDKRB1 Gene - From: PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icatibant Approved Pharma Antagonist, antagonist 16
Perindopril Approved Pharma ACE inhibitor, Angiotensin-converting enzyme (ACE) inhibitor 46
Bradykinin Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 49
KALLIDIN Pharma Full agonist, Agonist 0
HOE 140 Pharma Potent and selective B2 antagonist 0

(7) Additional Compounds for BDKRB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Phe8psi(CH-NH)-Arg9]-Bradykinin
118122-39-7

(5) Tocris Compounds for BDKRB1 Gene

Compound Action Cas Number
[Phe8psi(CH-NH)-Arg9]-Bradykinin Selective B2 agonist 118122-39-7
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) 58-82-2
HOE 140 Potent and selective B2 antagonist 130308-48-4
Lys-[Des-Arg9]Bradykinin Selective B1 agonist 71800-36-7
R 715 Potent and selective B1 antagonist 185052-09-9

(11) ApexBio Compounds for BDKRB1 Gene

Compound Action Cas Number
[Phe8Ψ(CH-NH)-Arg9]-Bradykinin 118122-39-7
Bombinakinin M 509151-65-9
Bombinakinin-GAP 573671-91-7
ELN441958 Potent and selective bradykinin B1 receptor antagonist 913064-47-8
HOE 140 130308-48-4
Lys-[Des-Arg9]Bradykinin 71800-36-7
Lys-Bradykinin 342-10-9
MEN 11270 235082-52-7
R 715 185052-09-9
R 892 229030-05-1
Sar-[D-Phe8]-des-Arg9-Bradykinin 126959-88-4
genes like me logo Genes that share compounds with BDKRB1: view

Transcripts for BDKRB1 Gene

mRNA/cDNA for BDKRB1 Gene

Unigene Clusters for BDKRB1 Gene

Bradykinin receptor B1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for BDKRB1 (Bradykinin RB1/BDKRB1)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB1 Gene

No ASD Table

Relevant External Links for BDKRB1 Gene

GeneLoc Exon Structure for
BDKRB1
ECgene alternative splicing isoforms for
BDKRB1

Expression for BDKRB1 Gene

mRNA expression in normal human tissues for BDKRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BDKRB1 Gene

This gene is overexpressed in Pancreas (x9.8), Esophagus - Mucosa (x5.5), and Testis (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of BDKRB1 Gene:

BDKRB1

SOURCE GeneReport for Unigene cluster for BDKRB1 Gene:

Hs.525572
genes like me logo Genes that share expression patterns with BDKRB1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BDKRB1 Gene

Orthologs for BDKRB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BDKRB1 34
  • 81.58 (n)
  • 77.21 (a)
BDKRB1 35
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BDKRB1 34
  • 80.65 (n)
  • 75.57 (a)
BDKRB1 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bdkrb1 34
  • 79.34 (n)
  • 75.08 (a)
Bdkrb1 16
Bdkrb1 35
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BDKRB1 34
  • 99.43 (n)
  • 99.15 (a)
BDKRB1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bdkrb1 34
  • 78.38 (n)
  • 74.68 (a)
oppossum
(Monodelphis domestica)
Mammalia BDKRB1 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BDKRB1 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves BDKRB1 34
  • 55.1 (n)
  • 44.41 (a)
BDKRB1 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bdkrb1 35
  • 33 (a)
OneToOne
Species where no ortholog for BDKRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB1 Gene

ENSEMBL:
Gene Tree for BDKRB1 (if available)
TreeFam:
Gene Tree for BDKRB1 (if available)

Paralogs for BDKRB1 Gene

Paralogs for BDKRB1 Gene

genes like me logo Genes that share paralogs with BDKRB1: view

Variants for BDKRB1 Gene

Sequence variations from dbSNP and Humsavar for BDKRB1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2229459 - 96,264,431(+) CACAG(C/T)GCTGA reference, missense
rs8004609 - 96,264,632(+) GGGCC(A/G)GCTCT reference, missense
rs11848191 -- 96,262,627(+) ttttt(G/T)ttgtt intron-variant
rs34334635 -- 96,261,785(+) GAGCC(A/G)CATAA intron-variant
rs3073017 -- 96,262,625(+) TTTTT(-/TTG)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BDKRB1 Gene

Variant ID Type Subtype PubMed ID
esv3635420 CNV gain 21293372
nsv565648 CNV loss 21841781

Variation tolerance for BDKRB1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BDKRB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BDKRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDKRB1 Gene

Disorders for BDKRB1 Gene

Relevant External Links for BDKRB1

Genetic Association Database (GAD)
BDKRB1
Human Genome Epidemiology (HuGE) Navigator
BDKRB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BDKRB1

No disorders were found for BDKRB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BDKRB1 Gene

Publications for BDKRB1 Gene

  1. A synergistic association of ACE I/D and eNOS G894T gene variants with the progression of immunoglobulin A nephropathy - a pilot study. (PMID: 19546528) RodrA-guez-PAcrez J.C. … Torres A. (Am. J. Nephrol. 2009) 3 22 46 65
  2. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PMID: 15643125) Cui J. … Gavras H. (J. Hypertens. 2005) 3 22 46 65
  3. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. (PMID: 10422787) Jones C. … McIntyre P. (Eur. J. Pharmacol. 1999) 3 4 22 65
  4. Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). (PMID: 8660997) Bachvarov D.R. … Marceau F. (Genomics 1996) 3 4 22 65
  5. Expression cloning of a human B1 bradykinin receptor. (PMID: 8063797) Menke J.G. … Hess J.F. (J. Biol. Chem. 1994) 3 4 22 65

Products for BDKRB1 Gene

Sources for BDKRB1 Gene

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