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Aliases for BDKRB1 Gene

Aliases for BDKRB1 Gene

  • Bradykinin Receptor B1 2 3 5
  • BK-1 Receptor 3 4
  • BRADYB1 3 4
  • B1R 3 4
  • Bradykinin B1 Receptor 3
  • Bradykinin Receptor B2 3
  • Bradykinin Receptor 1 3
  • BDKRB2 3
  • B1BKR 3
  • BKB1R 3
  • BKR1 3

External Ids for BDKRB1 Gene

Previous GeneCards Identifiers for BDKRB1 Gene

  • GC14P094233
  • GC14P090539
  • GC14P094712
  • GC14P095792
  • GC14P096722
  • GC14P076907

Summaries for BDKRB1 Gene

Entrez Gene Summary for BDKRB1 Gene

  • Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for BDKRB1 Gene

BDKRB1 (Bradykinin Receptor B1) is a Protein Coding gene. Diseases associated with BDKRB1 include vaccinia and chronic inflammatory demyelinating polyneuritis. Among its related pathways are Signaling by GPCR and Complement and coagulation cascades. GO annotations related to this gene include G-protein coupled receptor activity and bradykinin receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for BDKRB1 Gene

  • This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Tocris Summary for BDKRB1 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Gene Wiki entry for BDKRB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB1 Gene

Genomics for BDKRB1 Gene

Regulatory Elements for BDKRB1 Gene

Promoters for BDKRB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BDKRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BDKRB1 Gene

Chromosome:
14
Start:
96,255,824 bp from pter
End:
96,268,967 bp from pter
Size:
13,144 bases
Orientation:
Plus strand

Genomic View for BDKRB1 Gene

Genes around BDKRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BDKRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BDKRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDKRB1 Gene

Proteins for BDKRB1 Gene

  • Protein details for BDKRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46663-BKRB1_HUMAN
    Recommended name:
    B1 bradykinin receptor
    Protein Accession:
    P46663
    Secondary Accessions:
    • A8K7F5
    • Q546S7
    • Q8N0Y8

    Protein attributes for BDKRB1 Gene

    Size:
    353 amino acids
    Molecular mass:
    40495 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BDKRB1 Gene

Proteomics data for BDKRB1 Gene at MOPED

Post-translational modifications for BDKRB1 Gene

  • Glycosylation at Asn 14, Asn 22, and Asn 185
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BDKRB1 Gene

Domains & Families for BDKRB1 Gene

Gene Families for BDKRB1 Gene

Suggested Antigen Peptide Sequences for BDKRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46663

UniProtKB/Swiss-Prot:

BKRB1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
genes like me logo Genes that share domains with BDKRB1: view

Function for BDKRB1 Gene

Molecular function for BDKRB1 Gene

GENATLAS Biochemistry:
bradykinin B1 receptor,selectively sensible to fragments of kinins,lacking the Cter Arg,G protein coupled receptor superfamily,putatively exercying protective role in the end stage renal disease (ESRD)
UniProtKB/Swiss-Prot Function:
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Gene Ontology (GO) - Molecular Function for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with BDKRB1: view
genes like me logo Genes that share phenotypes with BDKRB1: view

Animal Models for BDKRB1 Gene

MGI Knock Outs for BDKRB1:

Animal Model Products

miRNA for BDKRB1 Gene

miRTarBase miRNAs that target BDKRB1

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BDKRB1 Gene

Localization for BDKRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BDKRB1 Gene COMPARTMENTS Subcellular localization image for BDKRB1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
endoplasmic reticulum 4
nucleus 1

Gene Ontology (GO) - Cellular Components for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with BDKRB1: view

Pathways & Interactions for BDKRB1 Gene

genes like me logo Genes that share pathways with BDKRB1: view

Gene Ontology (GO) - Biological Process for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006954 inflammatory response IEA --
GO:0019233 sensory perception of pain IEA --
GO:0030308 negative regulation of cell growth IEA --
genes like me logo Genes that share ontologies with BDKRB1: view

No data available for SIGNOR curated interactions for BDKRB1 Gene

Drugs & Compounds for BDKRB1 Gene

(46) Drugs for BDKRB1 Gene - From: Novoseek, IUPHAR, DGIdb, HMDB, Tocris, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icatibant Approved Pharma Antagonist, antagonist 16
Perindopril Approved Pharma ACE inhibitor, Angiotensin-converting enzyme (ACE) inhibitor 44
Bradykinin Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 47
KALLIDIN Pharma Full agonist, Agonist 0
[<small>D</small>-Lys<sup>1</sup>,des-Arg<sup>10</sup>]kallidin Pharma Full agonist, Agonist 0

(11) Additional Compounds for BDKRB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Des-Arg9]-Bradykinin
15958-92-6
Bombinakinin M
509151-65-9
Lys-[Des-Arg9]Bradykinin
71800-36-7
Lys-Bradykinin
342-10-9

(5) Tocris Compounds for BDKRB1 Gene

Compound Action Cas Number
[Des-Arg9]-Bradykinin Bradykinin receptor agonist (B1 > B2) 15958-92-6
Bombinakinin M Potent bradykinin receptor agonist 509151-65-9
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) 58-82-2
Lys-[Des-Arg9]Bradykinin Selective B1 agonist 71800-36-7
Lys-Bradykinin Potent bradykinin receptor agonist (B2 > B1) 342-10-9
genes like me logo Genes that share compounds with BDKRB1: view

Transcripts for BDKRB1 Gene

Unigene Clusters for BDKRB1 Gene

Bradykinin receptor B1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB1 Gene

No ASD Table

Relevant External Links for BDKRB1 Gene

GeneLoc Exon Structure for
BDKRB1
ECgene alternative splicing isoforms for
BDKRB1

Expression for BDKRB1 Gene

mRNA expression in normal human tissues for BDKRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BDKRB1 Gene

This gene is overexpressed in Pancreas (x9.8), Esophagus - Mucosa (x5.5), and Testis (x4.5).

SOURCE GeneReport for Unigene cluster for BDKRB1 Gene Hs.525572

genes like me logo Genes that share expression patterns with BDKRB1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BDKRB1 Gene

Orthologs for BDKRB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BDKRB1 35
  • 81.58 (n)
  • 77.21 (a)
BDKRB1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BDKRB1 35
  • 80.65 (n)
  • 75.57 (a)
BDKRB1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bdkrb1 35
  • 79.34 (n)
  • 75.08 (a)
Bdkrb1 16
Bdkrb1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BDKRB1 35
  • 99.43 (n)
  • 99.15 (a)
BDKRB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bdkrb1 35
  • 78.38 (n)
  • 74.68 (a)
oppossum
(Monodelphis domestica)
Mammalia BDKRB1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BDKRB1 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves BDKRB1 35
  • 55.1 (n)
  • 44.41 (a)
BDKRB1 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bdkrb1 36
  • 33 (a)
OneToOne
Species with no ortholog for BDKRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB1 Gene

ENSEMBL:
Gene Tree for BDKRB1 (if available)
TreeFam:
Gene Tree for BDKRB1 (if available)

Paralogs for BDKRB1 Gene

Paralogs for BDKRB1 Gene

genes like me logo Genes that share paralogs with BDKRB1: view

Variants for BDKRB1 Gene

Sequence variations from dbSNP and Humsavar for BDKRB1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2229459 - 96,264,431(+) CACAG(C/T)GCTGA reference, missense
rs8004609 - 96,264,632(+) GGGCC(A/G)GCTCT reference, missense
rs870282 -- 96,263,072(-) ATGGA(A/G)GCAGA intron-variant
rs885841 -- 96,262,549(+) tgtta(A/T)CCTTA intron-variant
rs885842 -- 96,262,579(+) TTTCT(A/C)TTTTT intron-variant

Variation tolerance for BDKRB1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BDKRB1 Gene

HapMap Linkage Disequilibrium report
BDKRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BDKRB1 Gene

Disorders for BDKRB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BDKRB1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BDKRB1

Genetic Association Database (GAD)
BDKRB1
Human Genome Epidemiology (HuGE) Navigator
BDKRB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BDKRB1
genes like me logo Genes that share disorders with BDKRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BDKRB1 Gene

Publications for BDKRB1 Gene

  1. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PMID: 15643125) Cui J. … Gavras H. (J. Hypertens. 2005) 3 23 48 67
  2. Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. (PMID: 18809736) Klein J. … Bascands J.L. (FASEB J. 2009) 3 23
  3. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. (PMID: 19038786) Bertram C.M. … Bhoola K.D. (J. Leukoc. Biol. 2009) 3 23
  4. Stimulation of the bradykinin B(1) receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway. (PMID: 19184415) Molina L. … Poblete M.T. (Breast Cancer Res. Treat. 2009) 3 23
  5. A synergistic association of ACE I/D and eNOS G894T gene variants with the progression of immunoglobulin A nephropathy - a pilot study. (PMID: 19546528) RodrA-guez-PAcrez J.C. … Torres A. (Am. J. Nephrol. 2009) 3 23

Products for BDKRB1 Gene

Sources for BDKRB1 Gene

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