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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BDKRB1 Gene

protein-coding   GIFtS: 64
GCID: GC14P096722

Bradykinin Receptor B1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bradykinin Receptor B11 2     BKB1R2
B1R2 3     BKR12
BRADYB12 3     B1 Bradykinin Receptor2
BK-1 Receptor2 3     Bradykinin B1 Receptor2
B1BKR2     Bradykinin Receptor 12

External Ids:    HGNC: 10291   Entrez Gene: 6232   Ensembl: ENSG000001007397   OMIM: 6003375   UniProtKB: P466633   

Export aliases for BDKRB1 gene to outside databases

Previous GC identifers: GC14P094233 GC14P090539 GC14P094712 GC14P095792 GC14P076907


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BDKRB1 Gene:
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns,
shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate
responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is
synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion
concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for BDKRB1 Gene: 
BDKRB1 (bradykinin receptor B1) is a protein-coding gene. Diseases associated with BDKRB1 include c1 inhibitor deficiency, and erysipelas, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and ACE Inhibitor Pathway. GO annotations related to this gene include bradykinin receptor activity and peptide binding. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663
Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

summary for BDKRB1 Gene:
Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and
pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their
action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor.
Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation,
smooth muscle contraction and pain.

Gene Wiki entry for BDKRB1 (Bradykinin receptor B1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BDKRB1 gene promoter:
         Bach2   HOXA5   p300   SEF-1 (1)   XBP-1   Nkx2-5   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBDKRB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BDKRB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BDKRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1-q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.1-q32.2

BDKRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDKRB1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096722:  view genomic region     (about GC identifiers)

Start:
96,722,161 bp from pter      End:
96,735,304 bp from pter
Size:
13,144 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663 (See protein sequence)
Recommended Name: B1 bradykinin receptor  
Size: 353 amino acids; 40495 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K7F5 Q546S7 Q8N0Y8

Explore the universe of human proteins at neXtProt for BDKRB1: NX_P46663

Explore proteomics data for BDKRB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46663

  • BDKRB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BDKRB1 Protein Expression
    REFSEQ proteins: NP_000701.2  
    ENSEMBL proteins: 
     ENSP00000216629   ENSP00000452064  
    Reactome Protein details: P46663
    Human Recombinant Protein Products for BDKRB1: 
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    Novus Biologicals BDKRB1 Protein
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for BDKRB1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9930991
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8063797
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    BDKRB1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BDKR: GPCR / Class A : Bradykinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: B1 receptor 
    Bradykinin receptors

    4 InterPro protein domains:
     IPR000496 Brdyknn_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR001186 Brdyknn_1_rcpt

    Graphical View of Domain Structure for InterPro Entry P46663

    ProtoNet protein and cluster: P46663

    2 Blocks protein domains:
    IPB000496 Bradykinin receptor signature
    IPB001186 B1 bradykinin receptor signature


    UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663
    Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1
    sub-subfamily


    BDKRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BKRB1_HUMAN, P46663
    Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

         Genatlas biochemistry entry for BDKRB1:
    bradykinin B1 receptor,selectively sensible to fragments of kinins,lacking the Cter Arg,G protein coupled receptor
    superfamily,putatively exercying protective role in the end stage renal disease (ESRD)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004947bradykinin receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0042277peptide binding IEA--
         
    BDKRB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BDKRB1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Bdkrb1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  integument 
     mortality/aging  normal  renal/urinary system 

    BDKRB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BDKRB1: Bdkrb1tm1Dgen Bdkrb1tm1Bdr Bdkrb2/Bdkrb1Bdkrb2/tm1Mki Bdkrb1tm2Bdr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BDKRB1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BDKRB1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BDKRB1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.37
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    ACE Inhibitor Pathway0.85
    ACE Inhibitor Pathway, Pharmacodynamics0.85
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.85
    3Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    4Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    5Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BDKRB1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BDKRB1
        eNOS Signaling

    5 BioSystems Pathways for BDKRB1
        ACE Inhibitor Pathway
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like
    Complement and Coagulation Cascades
    Peptide GPCRs


    5/9        Reactome Pathways for BDKRB1 (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding

    2 PharmGKB Pathways for BDKRB1
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for BDKRB1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Complement and coagulation cascades
    Regulation of actin cytoskeleton


    BDKRB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BDKRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/250 Interacting proteins for BDKRB1 (P466633 ENSP000002166294) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    MEP1AQ168193, ENSP000002305884I2D: score=1 STRING: ENSP00000230588
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADORA1ENSP000003085494STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001933negative regulation of protein phosphorylation IEA--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006950response to stress ----
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----

    BDKRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BDKRB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for BDKRB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HOE 140Potent and selective B2 antagonist[138614-30-9]
    WIN 64338 hydrochlorideBradykinin B2 antagonist[151039-63-3]
    R 715Potent and selective B1 antagonist[185052-09-9]
    Lys-[Des-Arg9]BradykininSelective B1 agonist[71800-36-7]
    BradykininEndogenous agonist at bradykinin receptors (B2 > B1)[6846-03-3]

    1 HMDB Compound for BDKRB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--

    10/36 IUPHAR Ligands for BDKRB1 (B1 receptor) (see all 36)    About this table 
    LigandTypeActionAffinityPubmed IDs
    compound 11 [PMID:12812482]
    AntagonistAntagonist10.512812482
    B-9858
    AntagonistAntagonist8.7 - 10.48995263 10422787 9276157
    B-9958
    AntagonistAntagonist9.2 - 10.316368899 9650825
    B-10356
    AntagonistAntagonist8.8 - 10.216368899
    NPC 18565
    AntagonistAntagonist10.28995263
    [125I]Hpp-desArg10HOE140
    NoneNone10--
    [des-Arg10]kallidin
    AgonistFull agonist9.6 - 1010422787 9313952 9111052
    D-Lys0-[des-Arg10]kallidin
    AgonistFull agonist9.59111052
    [3H]Lys-[des-Arg9]BK
    AgonistFull agonist9.4--
    [Leu9,des-Arg10]kallidin
    AntagonistAntagonist9.1 - 9.39111052 9313952

    10/18 Novoseek inferred chemical compound relationships for BDKRB1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    des-arg(10)-kallidin 94.9 9 9461531 (2), 10861834 (2), 9228537 (1), 11408528 (1) (see all 7)
    kallidin 87 6 10419551 (4), 9652332 (1)
    icatibant 76.8 2 10692400 (1), 15345332 (1)
    kininogen 67.2 4 10596865 (1), 19725054 (1), 20107486 (1)
    enalaprilat 57.9 1 18201802 (1)
    dimethyl sulfate 42.3 2 15705059 (2)
    puromycin 33 2 9461531 (1)
    cycloheximide 27.8 4 9461531 (1), 9822888 (1), 15743925 (1)
    phosphoinositide 26.1 1 10861834 (1)
    captopril 21.4 1 12424228 (1)

    1 PharmGKB related drug/compound annotation for BDKRB1 gene    About this table
    Drug/compound PharmGKB Annotation
    perindoprilCA  

    Search CenterWatch for drugs/clinical trials and news about BDKRB1 / BKRB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for BDKRB1 gene: 
    NM_000710.3  

    Unigene Cluster for BDKRB1:

    Bradykinin receptor B1
    Hs.525572  [show with all ESTs]
    Unigene Representative Sequence: AK309528
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216629(uc001yfh.3) ENST00000553356 ENST00000557122
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    Additional mRNA sequence: 

    AJ238044.1 AK291970.1 AK309528.1 BC034705.1 U12512.1 

    2 DOTS entries:

    DT.308969  DT.120783271 

    24/87 AceView cDNA sequences (see all 87):

    AI742135 AI803477 AY275465 AW239080 BU540691 NM_000710 AI242364 CA432819 
    CD216772 AI095360 BQ014905 X86165 BQ024471 BC074895 CA430240 BM823930 
    BQ917469 BC074894 AU142100 AJ238044 AI761846 BX471529 BQ436655 X69680 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BDKRB1 expression in normal human tissues (normalized intensities)      BDKRB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCCTGGCA
    BDKRB1 Expression
    About this image


    BDKRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
     
     Mesenchymal Stem Cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Colon (Gastrointestinal Tract)
             Human Colonic Smooth Muscle Cells (HCoSMC)   

    See BDKRB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BDKRB1

    SOURCE GeneReport for Unigene cluster: Hs.525572
        SABiosciences Expression via Pathway-Focused PCR Arrays including BDKRB1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BDKRB1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bdkrb11 , 5 bradykinin receptor, beta 11, 5 79.34(n)1
    75.08(a)1
      12 (55.81 cM)5
    120611  NM_007539.21  NP_031565.11 
     1056030855 
    chicken
    (Gallus gallus)
    Aves BDKRB11 bradykinin receptor B1 55.29(n)
    44.41(a)
      772372  NM_001080720.1  NP_001074189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bdkrb11 bradykinin receptor B1 50.51(n)
    40.34(a)
      368199  NM_183073.1  NP_898896.1 


    ENSEMBL Gene Tree for BDKRB1 (if available)
    TreeFam Gene Tree for BDKRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BDKRB1 gene
    RXFP32  AGTR22  GPR252  AGTR12  APLNR2  ACKR32  GPR152  BDKRB22  
    RXFP42  GPR1822  
    18/30 SIMAP similar genes for BDKRB1 using alignment to 2 protein entries:     BKRB1_HUMAN (see all proteins) (see all similar genes):
    GPR1    CXCR1    CCR2    CX3CR1    CXCR2    CMKLR1
    CCR-5    DKFZp686O088    BDKRB2    CCR8    IL8RB    CCR7
    AGTR1    CCR1    CCR4    CXCR4    SSTR5    CCR5

    BDKRB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/329 SNPs in BDKRB1 are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101471111,2
    C,A--96720588(+) cggtgG/Tctcac 1 -- us2k10--------
    rs1875585951,2
    --96720594(+) CTCACG/TCCTGT 1 -- us2k10--------
    rs1927806871,2
    --96720681(+) AGAAAC/TCCCGT 1 -- us2k10--------
    rs1503342781,2
    C--96720855(+) AAAAA-/AGAAAA 1 -- us2k10--------
    rs1499326811,2
    --96720931(+) CTGCTA/GTCTTC 1 -- us2k10--------
    rs1440117591,2
    --96720965(+) TTCTTC/TCACAG 1 -- us2k10--------
    rs1854609491,2
    --96720970(+) TCACAA/GATTTG 1 -- us2k10--------
    rs1485375631,2
    --96721051(+) GAGCCC/TGGGCC 1 -- us2k10--------
    rs774174631,2
    F--96721255(+) TGTGGC/TAGAGC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs605317221,2
    C,F--96721354(+) CTGAAG/TGGAGA 1 -- us2k13Minor allele frequency- T:0.14WA NA 240

    HapMap Linkage Disequilibrium report for BDKRB1 (96722161 - 96735304 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BDKRB1: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600337    OMIM disorders: --

    20/28 diseases for BDKRB1 (see all 28):    About MalaCards
    c1 inhibitor deficiency    erysipelas    polycystic kidney disease, type 1    chronic pain
    end stage renal failure    gastric ulcer    vaccinia    angioedema
    osteosarcoma    polycystic kidney disease    kidney disease    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    skin disease    multiple myeloma    inflammatory bowel disease
    myeloma    multiple sclerosis    myocardial infarction    prostate cancer


    BDKRB1 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for BDKRB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 48.7 26 8667195 (1), 9461531 (1), 10599786 (1), 10842322 (1) (see all 23)
    edema 8.36 1 12424228 (1)
    cancer 4.47 1 18182242 (1)
    renal failure chronic 3.33 1 12481150 (1)
    ischemia 0 2 15840906 (1), 19647718 (1)
    osteosarcoma 0 1 15345332 (1)
    tumors 0 5 19184415 (2), 19074839 (1)
    prostate cancer 0 7 12727816 (3), 12534343 (1), 18182242 (1)
    heart failure 0 1 15840906 (1)

    Genetic Association Database (GAD): BDKRB1
    Human Genome Epidemiology (HuGE) Navigator: BDKRB1 (15 documents)

    Export disorders for BDKRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BDKRB1 gene, integrated from 9 sources (see all 191):
    (articles sorted by number of sources associating them with BDKRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PubMed id 15643125)1, 4, 9 Cui J....Gavras H. (2005)
    2. Expression cloning of a human B1 bradykinin receptor. (PubMed id 8063797)1, 2, 9 Menke J.G.... Hess J.F. (1994)
    3. Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. (PubMed id 14499231)1, 4, 9 Dhamrait S.S....Montgomery H.E. (2003)
    4. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. (PubMed id 10422787)1, 2, 9 Jones C.... McIntyre P. (1999)
    5. Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). (PubMed id 8660997)1, 2, 9 Bachvarov D.R.... Marceau F. (1996)
    6. A synergistic association of ACE I/D and eNOS G894T g ene variants with the progression of immunoglobulin A nephropathy - a pilot stu dy. (PubMed id 19546528)1, 4, 9 RodrA-guez-PAcrez J.C....Torres A. (2009)
    7. Polymorphic genes for kinin receptors, nephropathy and blood pressure in type 2 diabetic patients. (PubMed id 12481150)1, 4, 9 Zychma M.J....Grzeszczak W. (2003)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. (PubMed id 19082699)1, 4 Brugts J.J....Simoons M.L. (2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 623 HGNC: 1029 AceView: BDKRB2 Ensembl:ENSG00000100739 euGenes: HUgn623
    ECgene: BDKRB1 Kegg: 623 H-InvDB: BDKRB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BDKRB1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Bradykinin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BDKRB1 gene:
    Search GeneIP for patents involving BDKRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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