Aliases for BDKRB1 Gene
External Ids for BDKRB1 Gene
Previous GeneCards Identifiers for BDKRB1 Gene
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for BDKRB1 Gene
BDKRB1 (Bradykinin Receptor B1) is a Protein Coding gene. Diseases associated with BDKRB1 include burns and erysipelas. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include peptide binding and bradykinin receptor activity. An important paralog of this gene is ACKR3.
UniProtKB/Swiss-Prot for BDKRB1 Gene
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation
Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.