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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BDKRB1 Gene

protein-coding GIFtS: 62
GCID: GC14P096722

bradykinin receptor B1

Explore 30 diseases affiliated with
BDKRB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bradykinin Receptor B1¹ ²		Bradyb1¹
B1BKR¹ ²		BKB1R²
BKR1¹ ²		B1 Bradykinin Receptor²
B1R² ³		Bradykinin B1 Receptor²
BRADYB1² ³		Bradykinin Receptor 1²
BK-1 Receptor² ³

External Ids:	HGNC: 1029¹	Entrez Gene: 623²	Ensembl: ENSG00000100739⁷	OMIM: 600337⁵	UniProtKB: P46663³

Export aliases for BDKRB1 gene to outside databases

Previous GC identifers: GC14P094233 GC14P090539 GC14P094712 GC14P095792 GC14P076907

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BDKRB1:

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and

allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these

pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo

following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately

resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have

been found for this gene. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663

Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

summary for BDKRB1:

Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and

pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their

action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor.

Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation,

smooth muscle contraction and pain.

Gene Wiki entry for BDKRB1 (Bradykinin receptor B1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BDKRB1 gene promoter:
Bach2 HOXA5 p300 SEF-1 (1) XBP-1 Nkx2-5 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BDKRB1 promoter sequence

Search SABiosciences Chromatin IP Primers for BDKRB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BDKRB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1-q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.1-q32.2

BDKRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDKRB1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P096722: view genomic region (about GC identifiers)

Start:	96,722,161 bp from pter	End:	96,735,304 bp from pter
Size:	13,144 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663 (See protein sequence)

Recommended Name: B1 bradykinin receptor

Size: 353 amino acids; 40495 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A8K7F5 Q546S7 Q8N0Y8

Explore the universe of human proteins at neXtProt for BDKRB1: NX_P46663

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P46663

BDKRB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000701.2

ENSEMBL proteins:

ENSP00000216629 ENSP00000452064

Reactome Protein details: P46663
Human Recombinant Protein Products for BDKRB1:

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	Uscn Proteins for BDKRB1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005783	endoplasmic reticulum	TAS	9930991
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8063797
GO:0016021	integral to membrane	--	--

BDKRB1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BDKRB1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BDKRB1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000496 Brdyknn_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

IPR001186 Brdyknn_1_rcpt

Graphical View of Domain Structure for InterPro Entry P46663

ProtoNet protein and cluster: P46663

2 Blocks protein families:

IPB000496 Bradykinin receptor signature

IPB001186 B1 bradykinin receptor signature

UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663

Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: BKRB1_HUMAN, P46663

Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

Genatlas biochemistry entry for BDKRB1:

bradykinin B1 receptor,selectively sensible to fragments of kinins,lacking the Cter Arg,G protein coupled receptor

superfamily,putatively exercying protective role in the end stage renal disease (ESRD)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004947	bradykinin receptor activity	IEA	--
GO:0042277	peptide binding	IEA	--

BDKRB1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for BDKRB1:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Bdkrb1):

behavior/neurological	cardiovascular system	homeostasis/metabolism	immune system	integument
mortality/aging	normal	renal/urinary system

BDKRB1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for BDKRB1: Bdkrb1^tm1Dgen Bdkrb1^tm1Bdr Bdkrb2/Bdkrb1^{Bdkrb2/tm1Mki} Bdkrb1^tm2Bdr

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BDKRB1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BDKRB1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics	1.00			ACE Inhibitor Pathway	0.85
	ACE Inhibitor Pathway, Pharmacodynamics	1.00

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for BDKRB1

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BDKRB1

eNOS Signaling

5 BioSystems Pathways for BDKRB1

	ACE Inhibitor Pathway
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Complement and Coagulation Cascades
	Peptide GPCRs

5/9 Reactome Pathways for BDKRB1 (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

2 PharmGKB Pathways for BDKRB1

	ACE Inhibitor Pathway, Pharmacodynamics
	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for BDKRB1):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeleton

BDKRB1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BDKRB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/250 Interacting proteins for BDKRB1 (P46663³ ENSP00000216629⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 250)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=1 STRING: ENSP00000286548
MEP1A	Q16819³, ENSP00000230588⁴	I2D: score=1 STRING: ENSP00000230588
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001933	negative regulation of protein phosphorylation	IEA	--
GO:0002687	positive regulation of leukocyte migration	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0007204	elevation of cytosolic calcium ion concentration	TAS	8063797
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IEA	--

BDKRB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BDKRB1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for BDKRB1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Bombinakinin M	Potent bradykinin receptor agonist	[509151-65-9]
[Des-Arg9]-Bradykinin	Bradykinin receptor agonist (B1 > B2)	[15958-92-6]
R 715	Potent and selective B1 antagonist	[185052-09-9]
Lys-[Des-Arg9]Bradykinin	Selective B1 agonist	[71800-36-7]
Bradykinin	Endogenous agonist at bradykinin receptors (B2 > B1)	[6846-03-3]

1 HMDB Compound for BDKRB1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Bradykinin	Callidin I (see all 5)	58-82-2	--

10/18 Novoseek chemical compound relationships for BDKRB1 gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
des-arg(10)-kallidin	94.9	9	9461531 (2), 10861834 (2), 9228537 (1), 11408528 (1) (see all 7)
kallidin	87	6	10419551 (4), 9652332 (1)
icatibant	76.8	2	10692400 (1), 15345332 (1)
kininogen	67.2	4	10596865 (1), 19725054 (1), 20107486 (1)
enalaprilat	57.9	1	18201802 (1)
dimethyl sulfate	42.3	2	15705059 (2)
puromycin	33	2	9461531 (1)
cycloheximide	27.8	4	9461531 (1), 9822888 (1), 15743925 (1)
phosphoinositide	26.1	1	10861834 (1)
captopril	21.4	1	12424228 (1)

1 PharmGKB related drug/compound annotation for BDKRB1 gene About this table

Drug/compound	PharmGKB Annotation
perindopril	CA

Search CenterWatch for drugs/clinical trials and news about BDKRB1 / BKRB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for BDKRB1 gene:

NM_000710.3

Unigene Cluster for BDKRB1:

Bradykinin receptor B1

Hs.525572 [show with all ESTs]

Unigene Representative Sequence: AK309528

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216629(uc001yfh.3) ENST00000553356 ENST00000557122

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Additional cDNA sequence:

AJ238044.1 AK291970.1 AK309528.1 BC034705.1 U12512.1

2 DOTS entries:

DT.308969 DT.120783271

24/87 AceView cDNA sequences (see all 87):

AI742135 NM_000710 CA432819 AU142100 CD216772 AI095360 AI803477 AI242364

BU540691 BM823930 BC074895 CA430240 BQ014905 AY275465 BQ024471 BQ917469

BC074894 AW239080 AJ238044 X86165 AA523879 BX473119 CF126800 AI762640

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BDKRB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCCTGGCA

About this image

BDKRB1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

See BDKRB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BDKRB1

SOURCE GeneReport for Unigene cluster: Hs.525572

SABiosciences Expression via Pathway-Focused PCR Arrays including BDKRB1:

G Protein Coupled Receptors 384HT in human mouse rat

Hypertension in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BDKRB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB1 gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BDKRB1¹	bradykinin receptor B1	55.29(n) 44.41(a)		772372 NM_001080720.1 NP_001074189.1
zebrafish (Danio rerio)	Actinopterygii	bdkrb1¹	bradykinin receptor B1	50.51(n) 40.34(a)		368199 NM_183073.1 NP_898896.1

ENSEMBL Gene Tree for BDKRB1 (if available)
TreeFam Gene Tree for BDKRB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BDKRB1 gene

RXFP3² AGTR2² AGTR1² GPR25² CXCR7² APLNR² GPR15² BDKRB2²

RXFP4² GPR182²

18/30 SIMAP similar genes for BDKRB1 using alignment to 2 protein entries: BKRB1_HUMAN (see all proteins) (see all similar genes):

CCR2 GPR1 CXCR1 CX3CR1 CXCR2 CMKLR1

CCR-5 DKFZp686O088 BDKRB2 CCR8 IL8RB CCR7

AGTR1 CCR1 CCR4 CXCR4 SSTR5 CCR5

BDKRB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10147111^1,2	C,A	--	96720588(+)	`cggtgG/Tctcac`	1	--	us2k¹		0	--	--	--	--
rs187558595^1,2		--	96720594(+)	`CTCACG/TCCTGT`	1	--	us2k¹		0	--	--	--	--
rs192780687^1,2		--	96720681(+)	`AGAAAC/TCCCGT`	1	--	us2k¹		0	--	--	--	--
rs150334278^1,2		--	96720855(+)	`GTCTC-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs149932681^1,2		--	96720931(+)	`CTGCTA/GTCTTC`	1	--	us2k¹		0	--	--	--	--
rs144011759^1,2		--	96720965(+)	`TTCTTC/TCACAG`	1	--	us2k¹		0	--	--	--	--
rs185460949^1,2		--	96720970(+)	`TCACAA/GATTTG`	1	--	us2k¹		0	--	--	--	--
rs148537563^1,2		--	96721051(+)	`GAGCCC/TGGGCC`	1	--	us2k¹		0	--	--	--	--
rs77417463^1,2	F	--	96721255(+)	`TGTGGC/TAGAGC`	1	--	us2k¹		1		WA	118
rs60531722^1,2	C	--	96721354(+)	`CTGAAG/TGGAGA`	1	--	us2k¹		3		WA NA	240

HapMap Linkage Disequilibrium report for BDKRB1 (96722161 - 96735304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BDKRB1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BDKRB1 for disorders           About GeneDecksing

OMIM gene information: 600337    OMIM disorders: --

20/30 diseases for BDKRB1 (see all 30):    About MalaCards

end stage renal failure erysipelas polycystic kidney disease inflammatory bowel disease

chronic pain intrahepatic cholangiocarcinoma kidney disease myocardial infarction

angioedema squamous cell carcinoma gastric ulcer multiple myeloma

bone cancer multiple sclerosis skin disease cholangiocarcinoma

osteosarcoma prostate cancer vaccinia hermaphroditism

9 Novoseek disease relationships for BDKRB1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	48.7	26	8667195 (1), 9461531 (1), 10599786 (1), 10842322 (1) (see all 23)
edema	8.36	1	12424228 (1)
cancer	4.47	1	18182242 (1)
renal failure chronic	3.33	1	12481150 (1)
ischemia	0	2	15840906 (1), 19647718 (1)
osteosarcoma	0	1	15345332 (1)
tumors	0	5	19184415 (2), 19074839 (1)
prostate cancer	0	7	12727816 (3), 12534343 (1), 18182242 (1)
heart failure	0	1	15840906 (1)

Genetic Association Database (GAD): BDKRB1
Human Genome Epidemiology (HuGE) Navigator: BDKRB1 (15 documents)

Export disorders for BDKRB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BDKRB1 gene, integrated from 9 sources (see all 187):
(articles sorted by number of sources associating them with BDKRB1)

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Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PubMed id 15643125)^{1, 4, 9} Cui J....Gavras H. (2005)
Expression cloning of a human B1 bradykinin receptor. (PubMed id 8063797)^{1, 2, 9} Menke J.G.... Hess J.F. (1994)
Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. (PubMed id 14499231)^{1, 4, 9} Dhamrait S.S....Montgomery H.E. (2003)
Molecular characterisation of cloned bradykinin B1 receptors from rat and human. (PubMed id 10422787)^{1, 2, 9} Jones C.... McIntyre P. (1999)
Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). (PubMed id 8660997)^{1, 2, 9} Bachvarov D.R.... Marceau F. (1996)
Polymorphic genes for kinin receptors, nephropathy and blood pressure in type 2 diabetic patients. (PubMed id 12481150)^{1, 4, 9} Zychma M.J....Grzeszczak W. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Bradykinin B2 receptor gene polymorphism is associated with altered urinary albumin/creatinine values in diabetic patients. (PubMed id 12025967)^{1, 4} Maltais I....Bachvarov D. (2002)
Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions. (PubMed id 8651911)^{1, 2} Yang X. and Polgar P. (1996)
Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1. (PubMed id 8808279)^{1, 3} Chai K.X....Chao L. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 623	HGNC: 1029	AceView: BDKRB2	Ensembl:ENSG00000100739	euGenes: HUgn623
ECgene: BDKRB1	Kegg: 623	H-InvDB: BDKRB1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BDKRB1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Bradykinin_receptor

Intellectual Property for BDKRB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BDKRB1 gene:
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