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Aliases for BDKRB1 Gene

Aliases for BDKRB1 Gene

  • Bradykinin Receptor B1 2 3
  • BK-1 Receptor 3 4
  • BRADYB1 3 4
  • B1R 3 4
  • Bradykinin Receptor B2 3
  • B1 Bradykinin Receptor 3
  • Bradykinin B1 Receptor 3
  • Bradykinin Receptor 1 3
  • BDKRB2 3
  • B1BKR 3
  • BKB1R 3
  • BKR1 3

External Ids for BDKRB1 Gene

Previous GeneCards Identifiers for BDKRB1 Gene

  • GC14P094233
  • GC14P090539
  • GC14P094712
  • GC14P095792
  • GC14P096722
  • GC14P076907

Summaries for BDKRB1 Gene

Entrez Gene Summary for BDKRB1 Gene

  • Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for BDKRB1 Gene

BDKRB1 (Bradykinin Receptor B1) is a Protein Coding gene. Diseases associated with BDKRB1 include burns and erysipelas. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include peptide binding and bradykinin receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for BDKRB1 Gene

  • This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

Tocris Summary for BDKRB1 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor. Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain.

Gene Wiki entry for BDKRB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB1 Gene

Genomics for BDKRB1 Gene

Regulatory Elements for BDKRB1 Gene

Genomic Location for BDKRB1 Gene

Start:
96,255,824 bp from pter
End:
96,268,967 bp from pter
Size:
13,144 bases
Orientation:
Plus strand

Genomic View for BDKRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BDKRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDKRB1 Gene

Proteins for BDKRB1 Gene

  • Protein details for BDKRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46663-BKRB1_HUMAN
    Recommended name:
    B1 bradykinin receptor
    Protein Accession:
    P46663
    Secondary Accessions:
    • A8K7F5
    • Q546S7
    • Q8N0Y8

    Protein attributes for BDKRB1 Gene

    Size:
    353 amino acids
    Molecular mass:
    40495 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BDKRB1 Gene

Proteomics data for BDKRB1 Gene at MOPED

Post-translational modifications for BDKRB1 Gene

  • Glycosylation at Asn14, Asn22, and Asn185
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BDKRB1 Gene

Domains for BDKRB1 Gene

Gene Families for BDKRB1 Gene

HGNC:
  • BDKR :GPCR / Class A : Bradykinin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for BDKRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46663

UniProtKB/Swiss-Prot:

BKRB1_HUMAN :
  • P46663
Family:
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
genes like me logo Genes that share domains with BDKRB1: view

Function for BDKRB1 Gene

Molecular function for BDKRB1 Gene

GENATLAS Biochemistry: bradykinin B1 receptor,selectively sensible to fragments of kinins,lacking the Cter Arg,G protein coupled receptor superfamily,putatively exercying protective role in the end stage renal disease (ESRD)
UniProtKB/Swiss-Prot Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

Gene Ontology (GO) - Molecular Function for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004947 bradykinin receptor activity IEA --
GO:0005515 protein binding IPI 23597562
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with BDKRB1: view
genes like me logo Genes that share phenotypes with BDKRB1: view

Animal Models for BDKRB1 Gene

MGI Knock Outs for BDKRB1:

Animal Model Products

miRNA for BDKRB1 Gene

miRTarBase miRNAs that target BDKRB1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BDKRB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BDKRB1 Gene

Localization for BDKRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BDKRB1 Gene COMPARTMENTS Subcellular localization image for BDKRB1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9930991
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8063797
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with BDKRB1: view

Pathways for BDKRB1 Gene

genes like me logo Genes that share pathways with BDKRB1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 8063797
genes like me logo Genes that share ontologies with BDKRB1: view

Compounds for BDKRB1 Gene

(5) Tocris Compounds for BDKRB1 Gene

Compound Action Cas Number
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) [58-82-2]
HOE 140 Potent and selective B2 antagonist [130308-48-4]
Lys-[Des-Arg9]Bradykinin Selective B1 agonist [71800-36-7]
MEN 11270 Selective B2 antagonist; analog of HOE 140 (Cat. No. 3014) [235082-52-7]
Sar-[D-Phe8]-des-Arg9-Bradykinin Potent and selective B1 agonist [126959-88-4]

(1) HMDB Compounds for BDKRB1 Gene

Compound Synonyms Cas Number PubMed IDs
Bradykinin
  • Callidin I
58-82-2

(36) IUPHAR Ligand for BDKRB1 Gene

Ligand Type Action Affinity Pubmed IDs
compound 11 [PMID:12812482] Antagonist Antagonist 10.5
B-9858 Antagonist Antagonist 10.4
B-9958 Antagonist Antagonist 10.3
B-10356 Antagonist Antagonist 10.2
[125I]Hpp-desArg10HOE140 None None 10
[des-Arg10]kallidin Agonist Full agonist 10
B-9430 Antagonist Antagonist 9.6
D-Lys0-[des-Arg10]kallidin Agonist Full agonist 9.5
[3H]Lys-[des-Arg9]BK Agonist Full agonist 9.4
icatibant Antagonist Antagonist 9.4
[Leu9,des-Arg10]kallidin Antagonist Antagonist 9.3
kallidin Agonist Full agonist 9.3
bradykinin Agonist Full agonist 9.3
R-715 Antagonist Antagonist 9.2
SSR240612 Antagonist Antagonist 9.2
compound 12 [PMID:12723943] Antagonist Antagonist 9.2
Met-Lys-bradykinin Agonist Full agonist 8.7
R 914 Antagonist Antagonist 8.6
chroman 28 Antagonist Antagonist 8.5
[des-Arg10]icatibant Antagonist Antagonist 8.4
JMV1431 Antagonist Antagonist 8.4
PS020990 Antagonist Antagonist 8.2
NVP-SAA164 Antagonist Antagonist 8.1
NPC 17731 Antagonist Antagonist 8.1
[D-Lys1,des-Arg10]kallidin Agonist Full agonist 7.6
[Leu8,des-Arg9]bradykinin Antagonist Antagonist 7.2
Lys-kallidin Agonist Full agonist 6.9
NPC 18565 Antagonist Antagonist 6.6
[des-Phe9,des-Arg10]kallidin Agonist Full agonist 6.2
Ac-Lys-[MeAla6,Leu8,des-Arg9]bradykinin Antagonist Antagonist 6.2
[des-Arg11]T-kinin Agonist Full agonist 5.9
[des-Pro8,des-Phe9,des-Arg10]kallidin Agonist Full agonist 5.9
[Sar,D-Phe8,des-Arg9]bradykinin Agonist Full agonist 5.7
T-kinin Agonist Full agonist 5.2
[des-Arg9]bradykinin Agonist Full agonist 5.1
[3H]Lys-[Leu8][des-Arg9]BK Antagonist Antagonist

(18) Novoseek inferred chemical compound relationships for BDKRB1 Gene

Compound -log(P) Hits PubMed IDs
des-arg(10)-kallidin 94.9 9
kallidin 87 5
icatibant 76.8 2
kininogen 67.2 3
enalaprilat 57.9 1

(1) PharmGKB related drug/compound annotations for BDKRB1 Gene

Drug/compound Annotation
perindopril CA
genes like me logo Genes that share compounds with BDKRB1: view

Transcripts for BDKRB1 Gene

mRNA/cDNA for BDKRB1 Gene

Unigene Clusters for BDKRB1 Gene

Bradykinin receptor B1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BDKRB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB1 Gene

No ASD Table

Relevant External Links for BDKRB1 Gene

GeneLoc Exon Structure for
BDKRB1
ECgene alternative splicing isoforms for
BDKRB1

Expression for BDKRB1 Gene

mRNA expression in normal human tissues for BDKRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BDKRB1 Gene

This gene is overexpressed in Pancreas (9.8), Esophagus - Mucosa (5.5), and Testis (4.5).

SOURCE GeneReport for Unigene cluster for BDKRB1 Gene Hs.525572

genes like me logo Genes that share expressions with BDKRB1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for BDKRB1 Gene

Orthologs for BDKRB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BDKRB1 35
  • 99.43 (n)
  • 99.15 (a)
BDKRB1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BDKRB1 35
  • 81.58 (n)
  • 77.21 (a)
BDKRB1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BDKRB1 35
  • 80.65 (n)
  • 75.57 (a)
BDKRB1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bdkrb1 35
  • 79.34 (n)
  • 75.08 (a)
Bdkrb1 16
Bdkrb1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BDKRB1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BDKRB1 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bdkrb1 35
  • 78.38 (n)
  • 74.68 (a)
chicken
(Gallus gallus)
Aves BDKRB1 35
  • 55.1 (n)
  • 44.41 (a)
BDKRB1 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bdkrb1 36
  • 33 (a)
OneToOne
Species with no ortholog for BDKRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB1 Gene

ENSEMBL:
Gene Tree for BDKRB1 (if available)
TreeFam:
Gene Tree for BDKRB1 (if available)

Paralogs for BDKRB1 Gene

Paralogs for BDKRB1 Gene

genes like me logo Genes that share paralogs with BDKRB1: view

Variants for BDKRB1 Gene

Sequence variations from dbSNP and Humsavar for BDKRB1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs870282 -- 96,263,072(-) ATGGA(A/G)GCAGA intron-variant
rs885841 -- 96,262,549(+) tgtta(A/T)CCTTA intron-variant
rs885842 -- 96,262,579(+) TTTCT(A/C)TTTTT intron-variant
rs885845 -- 96,263,391(+) TGTAC(C/T)GGGAT intron-variant
rs2071083 -- 96,263,509(+) CGCTC(A/G)ACTCC intron-variant

Relevant External Links for BDKRB1 Gene

HapMap Linkage Disequilibrium report
BDKRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BDKRB1 Gene

Disorders for BDKRB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for BDKRB1 Gene including...

Search for BDKRB1 Gene in MalaCards »

(9) Novoseek inferred disease relationships for BDKRB1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 48.7 23
edema 8.36 1
cancer 4.47 1
renal failure chronic 3.33 1
ischemia 0 2

Relevant External Links for BDKRB1

Genetic Association Database (GAD)
BDKRB1
Human Genome Epidemiology (HuGE) Navigator
BDKRB1
genes like me logo Genes that share disorders with BDKRB1: view

No data available for UniProtKB/Swiss-Prot for BDKRB1 Gene

Publications for BDKRB1 Gene

  1. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. (PMID: 10422787) Jones C. … McIntyre P. (Eur. J. Pharmacol. 1999) 3 4 23
  2. Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). (PMID: 8660997) Bachvarov D.R. … Marceau F. (Genomics 1996) 3 4 23
  3. Expression cloning of a human B1 bradykinin receptor. (PMID: 8063797) Menke J.G. … Hess J.F. (J. Biol. Chem. 1994) 3 4 23
  4. Polymorphic genes for kinin receptors, nephropathy and blood pressure in type 2 diabetic patients. (PMID: 12481150) Zychma M.J. … Grzeszczak W. (Am. J. Nephrol. 2003) 3 23 48
  5. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PMID: 15643125) Cui J. … Gavras H. (J. Hypertens. 2005) 3 23 48

Products for BDKRB1 Gene

Sources for BDKRB1 Gene

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