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BDKRB1 Gene

protein-coding   GIFtS: 64
GCID: GC14P096722

Bradykinin Receptor B1

  See BDKRB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bradykinin Receptor B11 2     BKB1R2
B1R2 3     BKR12
BRADYB12 3     B1 Bradykinin Receptor2
BK-1 Receptor2 3     Bradykinin B1 Receptor2
B1BKR2     Bradykinin Receptor 12

External Ids:    HGNC: 10291   Entrez Gene: 6232   Ensembl: ENSG000001007397   OMIM: 6003375   UniProtKB: P466633   

Export aliases for BDKRB1 gene to outside databases

Previous GC identifers: GC14P094233 GC14P090539 GC14P094712 GC14P095792 GC14P076907


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BDKRB1 Gene:
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns,
shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate
responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is
synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion
concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for BDKRB1 Gene:
BDKRB1 (bradykinin receptor B1) is a protein-coding gene. Diseases associated with BDKRB1 include burns, and erysipelas. GO annotations related to this gene include bradykinin receptor activity and peptide binding. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663
Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

summary for BDKRB1 Gene:
Bradykinin and related kinins are a family of small peptides which act as mediators of inflammation and
pain. They exert a variety of biological effects on the endothelium and peripheral circulation through their
action on two G-protein-coupled bradykinin receptor subtypes, the B1 receptor and the B2 receptor.
Bradykinin is an important pro-inflammatory molecule that causes vasodilation, plasma protein extravasation,
smooth muscle contraction and pain.

Gene Wiki entry for BDKRB1 (Bradykinin receptor B1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the BDKRB1 gene promoter:
         Bach2   HOXA5   p300   SEF-1 (1)   XBP-1   Nkx2-5   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBDKRB1 promoter sequence
   Search Chromatin IP Primers for BDKRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BDKRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1-q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.1-q32.2

BDKRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDKRB1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096722:  view genomic region     (about GC identifiers)

Start:
96,722,161 bp from pter      End:
96,735,304 bp from pter
Size:
13,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663 (See protein sequence)
Recommended Name: B1 bradykinin receptor  
Size: 353 amino acids; 40495 Da
Secondary accessions: A8K7F5 Q546S7 Q8N0Y8

Explore the universe of human proteins at neXtProt for BDKRB1: NX_P46663

Explore proteomics data for BDKRB1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn14, Asn22, Asn185

  • See BDKRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000701.2  
    ENSEMBL proteins: 
     ENSP00000216629   ENSP00000452064  
    Reactome Protein details: P46663

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BDKR: GPCR / Class A : Bradykinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: B1 receptor
    Bradykinin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001186 Brdyknn_1_rcpt
     IPR000496 Brdyknn_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P46663

    ProtoNet protein and cluster: P46663

    2 Blocks protein domains:
    IPB000496 Bradykinin receptor signature
    IPB001186 B1 bradykinin receptor signature


    UniProtKB/Swiss-Prot: BKRB1_HUMAN, P46663
    Similarity: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1
    sub-subfamily


    Find genes that share domains with BDKRB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BKRB1_HUMAN, P46663
    Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation

         Genatlas biochemistry entry for BDKRB1:
    bradykinin B1 receptor,selectively sensible to fragments of kinins,lacking the Cter Arg,G protein coupled receptor
    superfamily,putatively exercying protective role in the end stage renal disease (ESRD)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004947bradykinin receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0042277peptide binding IEA--
         
    Find genes that share ontologies with BDKRB1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BDKRB1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Bdkrb1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  integument 
     mortality/aging  normal  renal/urinary system 

    Find genes that share phenotypes with BDKRB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BDKRB1: Bdkrb1tm1Dgen Bdkrb1tm1Bdr Bdkrb2/Bdkrb1Bdkrb2/tm1Mki Bdkrb1tm2Bdr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BDKRB1
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    miRTarBase miRNAs that target BDKRB1:
    hsa-mir-124-3p (MIRT023170)

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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BKRB1_HUMAN, P46663: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9930991
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8063797
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with BDKRB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BDKRB1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway0.00
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    3Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    4Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    5Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with BDKRB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BDKRB1
        eNOS Signaling

    5 BioSystems Pathways for BDKRB1
        ACE Inhibitor Pathway
    Regulation of Actin Cytoskeleton
    Complement and Coagulation Cascades
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    3 Reactome Pathways for BDKRB1
        Peptide ligand-binding receptors
    G alpha (q) signalling events
    G alpha (i) signalling events

    2 PharmGKB Pathways for BDKRB1
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for BDKRB1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Complement and coagulation cascades
    Inflammatory mediator regulation of TRP channels
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BDKRB1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BDKRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BDKRB1 (P466631, 3 ENSP000002166294) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    KNG1P010421, ENSP000002650234EBI-6623218,EBI-6623250 STRING: ENSP00000265023
    MEP1AQ168193, ENSP000002305884I2D: score=1 STRING: ENSP00000230588
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001933negative regulation of protein phosphorylation IEA--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS8063797

    Find genes that share ontologies with BDKRB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for BDKRB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HOE 140Potent and selective B2 antagonist[138614-30-9]
    WIN 64338 hydrochlorideBradykinin B2 antagonist[151039-63-3]
    R 715Potent and selective B1 antagonist[185052-09-9]
    Lys-[Des-Arg9]BradykininSelective B1 agonist[71800-36-7]
    BradykininEndogenous agonist at bradykinin receptors (B2 > B1)[6846-03-3]

    1 HMDB Compound for BDKRB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--

    Selected IUPHAR Ligands for BDKRB1 (B1 receptor) (see all 36)    About this table
    LigandTypeActionAffinityPubmed IDs
    compound 11 [PMID:12812482]
    AntagonistAntagonist10.512812482
    B-9858
    AntagonistAntagonist8.7 - 10.48995263 10422787 9276157
    B-9958
    AntagonistAntagonist9.2 - 10.316368899 9650825
    B-10356
    AntagonistAntagonist8.8 - 10.216368899
    NPC 18565
    AntagonistAntagonist10.28995263
    [125I]Hpp-desArg10HOE140
    NoneNone10--
    [des-Arg10]kallidin
    AgonistFull agonist9.6 - 1010422787 9313952 9111052
    D-Lys0-[des-Arg10]kallidin
    AgonistFull agonist9.59111052
    [3H]Lys-[des-Arg9]BK
    AgonistFull agonist9.4--
    [Leu9,des-Arg10]kallidin
    AntagonistAntagonist9.1 - 9.39111052 9313952

    Selected Novoseek inferred chemical compound relationships for BDKRB1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    des-arg(10)-kallidin 94.9 9 9461531 (2), 10861834 (2), 9228537 (1), 11408528 (1) (see all 7)
    kallidin 87 6 10419551 (4), 9652332 (1)
    icatibant 76.8 2 10692400 (1), 15345332 (1)
    kininogen 67.2 4 10596865 (1), 19725054 (1), 20107486 (1)
    enalaprilat 57.9 1 18201802 (1)
    dimethyl sulfate 42.3 2 15705059 (2)
    puromycin 33 2 9461531 (1)
    cycloheximide 27.8 4 9461531 (1), 9822888 (1), 15743925 (1)
    phosphoinositide 26.1 1 10861834 (1)
    captopril 21.4 1 12424228 (1)

    1 PharmGKB related drug/compound annotation for BDKRB1 gene    About this table
    Drug/compound PharmGKB Annotation
    perindoprilCA  



    Find genes that share compounds with BDKRB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BDKRB1 gene: 
    NM_000710.3  

    Unigene Cluster for BDKRB1:

    Bradykinin receptor B1
    Hs.525572  [show with all ESTs]
    Unigene Representative Sequence: AK309528
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216629(uc001yfh.3) ENST00000553356 ENST00000557122
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    Additional mRNA sequence: 

    AJ238044.1 AK291970.1 AK309528.1 BC034705.1 U12512.1 

    2 DOTS entries:

    DT.308969  DT.120783271 

    Selected AceView cDNA sequences (see all 87):

    AY275465 NM_000710 AI803477 AI242364 BQ014905 AI095360 AU142100 BQ917469 
    BM823930 CA432819 AJ238044 AW239080 CA430240 BU540691 BC074894 BQ024471 
    X86165 AI742135 BC074895 CD216772 BP340852 CB126972 CF128364 CF127506 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BDKRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCCTGGCA
    BDKRB1 Expression
    About this image


    BDKRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
     
     Brain (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus
    BDKRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BDKRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525572
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BDKRB1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BDKRB1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bdkrb11 , 5 bradykinin receptor, beta 11, 5 79.34(n)1
    75.08(a)1
      12 (55.81 cM)5
    120611  NM_007539.21  NP_031565.11 
     1056030855 
    chicken
    (Gallus gallus)
    Aves BDKRB11 bradykinin receptor B1 55.1(n)
    44.41(a)
      772372  NM_001080720.1  NP_001074189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bdkrb16
    bradykinin receptor B1
    33(a)
    1 ↔ 1
    17(2611654-2612733) ENSDARG00000020744


    ENSEMBL Gene Tree for BDKRB1 (if available)
    TreeFam Gene Tree for BDKRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BDKRB1 gene
    RXFP32  AGTR22  GPR252  AGTR12  APLNR2  ACKR32  GPR152  BDKRB22  
    RXFP42  GPR1822  
    Selected SIMAP similar genes for BDKRB1 using alignment to 2 protein entries:     BKRB1_HUMAN (see all proteins) (see all similar genes):
    CCR2    GPR1    CXCR1    CX3CR1    CXCR2    CMKLR1
    CCR-5    DKFZp686O088    BDKRB2    CCR8    IL8RB    CCR7
    AGTR1    CCR1    CCR4    CXCR4    SSTR5    CCR5

    Find genes that share paralogs with BDKRB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for BDKRB1 (see all 329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101471111,2
    C,A--96720588(+) cggtgG/Tctcac 1 -- us2k10--------
    rs1875585951,2
    --96720594(+) CTCACG/TCCTGT 1 -- us2k10--------
    rs1927806871,2
    --96720681(+) AGAAAC/TCCCGT 1 -- us2k10--------
    rs1503342781,2
    C--96720855(+) AAAAA-/AGAAAA 1 -- us2k10--------
    rs1499326811,2
    --96720931(+) CTGCTA/GTCTTC 1 -- us2k10--------
    rs1440117591,2
    --96720965(+) TTCTTC/TCACAG 1 -- us2k10--------
    rs1854609491,2
    --96720970(+) TCACAA/GATTTG 1 -- us2k10--------
    rs1485375631,2
    --96721051(+) GAGCCC/TGGGCC 1 -- us2k10--------
    rs774174631,2
    F--96721255(+) TGTGGC/TAGAGC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs605317221,2
    C,F--96721354(+) CTGAAG/TGGAGA 1 -- us2k13Minor allele frequency- T:0.14WA NA 240

    HapMap Linkage Disequilibrium report for BDKRB1 (96722161 - 96735304 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BDKRB1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing BDKRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for BDKRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600337    OMIM disorders: --

    4 diseases for BDKRB1:    
    About MalaCards
    burns    erysipelas    c1 inhibitor deficiency    polycystic kidney disease, type 1


    Find genes that share disorders with BDKRB1           About GenesLikeMe

    9 Novoseek inferred disease relationships for BDKRB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 48.7 26 8667195 (1), 9461531 (1), 10599786 (1), 10842322 (1) (see all 23)
    edema 8.36 1 12424228 (1)
    cancer 4.47 1 18182242 (1)
    renal failure chronic 3.33 1 12481150 (1)
    ischemia 0 2 15840906 (1), 19647718 (1)
    osteosarcoma 0 1 15345332 (1)
    tumors 0 5 19184415 (2), 19074839 (1)
    prostate cancer 0 7 12727816 (3), 12534343 (1), 18182242 (1)
    heart failure 0 1 15840906 (1)

    Genetic Association Database (GAD): BDKRB1
    Human Genome Epidemiology (HuGE) Navigator: BDKRB1 (15 documents)

    Export disorders for BDKRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BDKRB1 gene, integrated from 10 sources (see all 194):
    (articles sorted by number of sources associating them with BDKRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PubMed id 15643125)1, 4, 9 Cui J....Gavras H. (J. Hypertens. 2005)
    2. Expression cloning of a human B1 bradykinin receptor. (PubMed id 8063797)1, 2, 9 Menke J.G.... Hess J.F. (J. Biol. Chem. 1994)
    3. Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. (PubMed id 14499231)1, 4, 9 Dhamrait S.S....Montgomery H.E. (Eur. Heart J. 2003)
    4. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. (PubMed id 10422787)1, 2, 9 Jones C.... McIntyre P. (Eur. J. Pharmacol. 1999)
    5. Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). (PubMed id 8660997)1, 2, 9 Bachvarov D.R.... Marceau F. (Genomics 1996)
    6. A synergistic association of ACE I/D and eNOS G894T gene variants with the progression of immunoglobulin A nephropathy - a pilot study. (PubMed id 19546528)1, 4, 9 RodrA-guez-PAcrez J.C....Torres A. (Am. J. Nephrol. 2009)
    7. Polymorphic genes for kinin receptors, nephropathy and blood pressure in type 2 diabetic patients. (PubMed id 12481150)1, 4, 9 Zychma M.J....Grzeszczak W. (Am. J. Nephrol. 2003)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. (PubMed id 19082699)1, 4 Brugts J.J....Simoons M.L. (Cardiovasc Drugs Ther 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 623 HGNC: 1029 AceView: BDKRB2 Ensembl:ENSG00000100739 euGenes: HUgn623
    ECgene: BDKRB1 Kegg: 623 H-InvDB: BDKRB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BDKRB1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Bradykinin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BDKRB1 gene:
    Search GeneIP for patents involving BDKRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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