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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BDH2 Gene

protein-coding   GIFtS: 52
GCID: GC04M103998

3-hydroxybutyrate dehydrogenase, type 2

(Previous name: dehydrogenase/reductase (SDR family) member 6 )
(Previous symbol: DHRS6)
 Explore 4 diseases affiliated with
BDH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BDH2    

Aliases
for BDH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
3-Hydroxybutyrate Dehydrogenase, Type 21 2     Oxidoreductase UCPA2 3
DHRS61 2 3     R-Beta-Hydroxybutyrate Dehydrogenase2 3
PRO209331 2     FLJ132611
SDR15C11 2     3-Hydroxybutyrate Dehydrogenase Type 22
UCPA-OR1 2     EFA6R2
UNQ63081 2     Short Chain Dehydrogenase/Reductase Family 15C, Member 12
Dehydrogenase/Reductase (SDR Family) Member 61 2     EC 1.1.1.-3
Dehydrogenase/Reductase SDR Family Member 62 3     EC 1.1.1.303

External Ids:    HGNC: 323891   Entrez Gene: 568982   Ensembl: ENSG000001640397   UniProtKB: Q9BUT13   

Export aliases for BDH2 gene to outside databases

Previous GC identifers: GC04M104359 GC04M104218 GC04M099732


Summaries
for BDH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: BDH2_HUMAN, Q9BUT1
Function: Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares
structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron
homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)




Genomic Views
for BDH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BDH2 gene promoter:
         TBP   Olf-1   IRF-1   FOXL1   AREB6   IRF-2   SRY   Nkx6-1   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BDH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BDH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BDH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

BDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BDH2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M103998:  view genomic region     (about GC identifiers)

Start:
 103,998,782 bp from pter      End:
 104,021,040 bp from pter
Size:
 22,259 bases      Orientation:
 minus strand

Proteins
for BDH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BDH2_HUMAN, Q9BUT1 (See protein sequence)
Recommended Name: 3-hydroxybutyrate dehydrogenase type 2  
Size: 245 amino acids; 26724 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for BDH2:
2AG5 (3D)    
Secondary accessions: A8K295 B4DUF6 Q503A0 Q6IA46 Q6UWD3 Q9H8S8 Q9NRX8
Alternative splicing: 3 isoforms:  Q9BUT1-1   Q9BUT1-2   Q9BUT1-3   

Explore the universe of human proteins at neXtProt for BDH2: NX_Q9BUT1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUT1

    • BDH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064524.3  
    ENSEMBL proteins: 
     ENSP00000296424   ENSP00000424173   ENSP00000421516   ENSP00000427442   ENSP00000422891  

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    Novus Biologicals BDH2 Proteins
    Novus Biologicals BDH2 Lysates
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    ProSpec Recombinant Protein for BDH2
    Uscn Proteins for BDH2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16380372
    GO:0005739NOT mitochondrion IDA16380372


    BDH2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for BDH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BDH2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BUT1

    ProtoNet protein and cluster: Q9BUT1

    2 Blocks protein families:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: BDH2_HUMAN, Q9BUT1
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    Function
    for BDH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BDH2_HUMAN, Q9BUT1
    Function: Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares
    structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron
    homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)
    Catalytic activity: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH
    Biophysicochemical properties: Kinetic parameters: KM=60 uM for NAD; KM=10 mM for R-hydroxybutyrate; Vmax=82
    nmol/min/mg enzyme (at 30 degrees Celsius); pH dependence: Optimum pH is 7.5-9.0;

    Enzyme Numbers (IUBMB): EC 1.1.1.301 EC 1.1.1.-1

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    SwitchGear 3'UTR luciferase reporter plasmid: BDH2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:00038583-hydroxybutyrate dehydrogenase activity IDA16380372
    GO:00086672,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity ----
    GO:0016491oxidoreductase activity ----
    GO:0016628oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISS--


    BDH2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for BDH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ketone body metabolism
    		Synthesis and degradation of ketone bodies0.56
    		Butanoate metabolism0.17
    2ketolysis
    		ketolysis1.00
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for BDH2 
        ketolysis


    3         Kegg Pathways  (Kegg details for BDH2):
        Synthesis and degradation of ketone bodies
    Butanoate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: BDH2_HUMAN, Q9BUT1
    Pathway: Siderophore biosynthesis


    BDH2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BDH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for BDH2 (ENSP000002964244) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AACSENSP000003248424STRING: ENSP00000324842
    OXCT1ENSP000001963714STRING: ENSP00000196371
    OXCT2ENSP000003619144STRING: ENSP00000361914
    HMGCLENSP000003636144STRING: ENSP00000363614
    BDH1ENSP000003509144STRING: ENSP00000350914
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006635fatty acid beta-oxidation IDA16380372
    GO:0009239enterobactin biosynthetic process ----
    GO:0019290siderophore biosynthetic process ISS--
    GO:0042168heme metabolic process ISS--
    GO:0055072iron ion homeostasis ISS--


    BDH2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BDH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BDH2

    6 HMDB Compounds for BDH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    (R)-3-Hydroxybutyric acid(R)-(-)-b-Hydroxybutyrate (see all 20)625-72-9--
    (S)-3-Hydroxybutyric acid(S)-3-hydroxy-Butanoic acid (see all 25)6168-83-8--
    3-Hydroxybutyric acid3-OH-butyric acid (see all 27)300-85-6--
    Acetoacetic acid3-Ketobutyrate (see all 9)541-50-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Search CenterWatch for drugs/clinical trials and news about BDH2 

    Transcripts
    for BDH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BDH2 gene: 
    NM_020139.3  

    Unigene Cluster for BDH2:

    3-hydroxybutyrate dehydrogenase, type 2
    Hs.124696  [show with all ESTs]
    Unigene Representative Sequence: NM_020139
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296424(uc003hwz.3) ENST00000492366 ENST00000464039 ENST00000475058
    ENST00000506521 ENST00000511354 ENST00000504285 ENST00000509245 ENST00000513518


    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate BDH2 (see all 12):
    hsa-miR-1178 hsa-miR-548am hsa-miR-4311 hsa-miR-4318 hsa-miR-4297 hsa-miR-4282 hsa-miR-548l hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BDH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BDH2 (see all 7)
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    OriGene siRNA: BDH2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF164790.1 AK023323.1 AK128463.1 AK290160.1 AK291335.1 AK300626.1 AY358841.1 BC001953.1 
    BC037277.2 BC095414.1 CR457309.1 

    24/26 DOTS entries (see all 26):

    DT.100809859  DT.95185359  DT.418705  DT.451650  DT.121253064  DT.100809860  DT.121252834  DT.121253007 
    DT.100761636  DT.121253151  DT.121253234  DT.121364875  DT.91861883  DT.92326978  DT.102824113  DT.91702012 
    DT.97791685  DT.121252797  DT.91837485  DT.91910021  DT.100809858  DT.100809867  DT.121253075  DT.97858719 

    24/305 AceView cDNA sequences (see all 305):

    BQ641518 CA414243 BP349943 BQ641860 AI669406 CR625169 AA747300 BQ575352 
    BQ018407 AA995087 AI127132 BM560424 AL703489 N75160 BQ641853 CR601062 
    BC037277 BE350470 BM560338 BP341786 BQ575493 AL555621 BU682310 BC001953 

    GeneLoc Exon Structure


    Expression
    for BDH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BDH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BDH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See BDH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BDH2

    SOURCE GeneReport for Unigene cluster: Hs.124696
        SABiosciences Expression via Pathway-Focused PCR Arrays including BDH2: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for BDH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for BDH2 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BDH21 3-hydroxybutyrate dehydrogenase, type 2 76.73(n)
    80(a)    		   422715  XM_420669.3  XP_420669.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.166322 Transcribed sequence with weak similarity to protein more 75.71(n)    BX740093.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.155842 Transcribed sequence with moderate similarity to protein more 78.31(n)    BM184141.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G031401 Rossmann-fold NAD(P)-binding domain-containing protein 46.22(n)
    34.87(a)    		   828065  NM_116548.2  NP_567251.2 
    rice
    (Oryza sativa)    		 Liliopsida Os07g06635001 hypothetical protein 43.61(n)
    37.08(a)    		   4344196  NM_001067085.2  NP_001060550.2 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ucpA6
    srlD6
    		 sorbitol-6-phosphate dehydrogenase
    		 33(a)
    20(a)
    		 1 ↔ 1
    possible ortholog
    		 Chromosome(2541854-2542645)
    Chromosome(2825759-2826538)


    ENSEMBL Gene Tree for BDH2 (if available)
    TreeFam Gene Tree for BDH2 (if available) 

    Paralogs
    for BDH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BDH2 gene
    DECR22  DCXR2  PECR2  HSD17B142  DHRS22  DHRS42  DHRS4L22  DECR12  
    10 SIMAP similar genes for BDH2 using alignment to 6 protein entries:     BDH2_HUMAN (see all proteins):
    SLC9B2    RDH13    DCXR    DHRS4    CBR4    HSD17B8
    DHRS2    HPGD    HSD17B4    HSD17B14

    BDH2 for paralogs           About GeneDecksing



    Genomic Variants
    for BDH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for BDH2
         1 CNV: 3505
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for BDH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BDH2 for disorders           About GeneDecksing

    4 diseases for BDH2:    About MalaCards
    alcohol dependence    alcoholism    pneumonia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: BDH2 (1 document)

    Export disorders for BDH2 gene to outside databases

    Publications
    for BDH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BDH2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with BDH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta- hydroxybutyrate dehydrogenase. (PubMed id 16380372)1, 2, 3 Guo K....Oppermann U. (2006)
    2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. Siderophore-mediated iron trafficking in humans is reg ulated by iron. (PubMed id 22527885)1 Liu Z....Devireddy L. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for BDH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing BDH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56898 HGNC: 32389 AceView: DHRS6 Ensembl:ENSG00000164039 euGenes: HUgn56898
    ECgene: BDH2 Kegg: 56898 H-InvDB: BDH2

    Other Databases showing BDH2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BDH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BDH2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BDH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BDH2 gene:
    Search GeneIP for patents involving BDH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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