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Aliases for BDH2 Gene

Aliases for BDH2 Gene

  • 3-Hydroxybutyrate Dehydrogenase, Type 2 2 3
  • Short Chain Dehydrogenase/Reductase Family 15C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 6 2 3
  • Dehydrogenase/Reductase SDR Family Member 6 3 4
  • R-Beta-Hydroxybutyrate Dehydrogenase 3 4
  • Oxidoreductase UCPA 3 4
  • SDR15C1 3 4
  • DHRS6 3 4
  • Short Chain Dehydrogenase/Reductase Family 15C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 15C 2
  • 3-Hydroxybutyrate Dehydrogenase Type 2 3
  • EC 4
  • EC 1.1.1.- 4
  • Member 1 2
  • PRO20933 3
  • UCPA-OR 3
  • UNQ6308 3
  • EFA6R 3

External Ids for BDH2 Gene

Previous HGNC Symbols for BDH2 Gene

  • DHRS6

Previous GeneCards Identifiers for BDH2 Gene

  • GC04M104359
  • GC04M104218
  • GC04M103998
  • GC04M099732

Summaries for BDH2 Gene

GeneCards Summary for BDH2 Gene

BDH2 (3-Hydroxybutyrate Dehydrogenase, Type 2) is a Protein Coding gene. Among its related pathways are Metabolism and Synthesis and Degradation of Ketone Bodies. GO annotations related to this gene include NAD binding and 3-hydroxybutyrate dehydrogenase activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for BDH2 Gene

  • Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDH2 Gene

Genomics for BDH2 Gene

Regulatory Elements for BDH2 Gene

Genomic Location for BDH2 Gene

103,077,613 bp from pter
103,099,883 bp from pter
22,271 bases
Minus strand

Genomic View for BDH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BDH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDH2 Gene

Proteins for BDH2 Gene

  • Protein details for BDH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    3-hydroxybutyrate dehydrogenase type 2
    Protein Accession:
    Secondary Accessions:
    • A8K295
    • B4DUF6
    • Q503A0
    • Q6IA46
    • Q6UWD3
    • Q9H8S8
    • Q9NRX8

    Protein attributes for BDH2 Gene

    245 amino acids
    Molecular mass:
    26724 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for BDH2 Gene

    Alternative splice isoforms for BDH2 Gene


neXtProt entry for BDH2 Gene

Proteomics data for BDH2 Gene at MOPED

Post-translational modifications for BDH2 Gene

  • Ubiquitination at Lys48 and Lys159
  • Modification sites at PhosphoSitePlus

Other Protein References for BDH2 Gene

No data available for DME Specific Peptides for BDH2 Gene

Domains for BDH2 Gene

Gene Families for BDH2 Gene

  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Suggested Antigen Peptide Sequences for BDH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BUT1
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with BDH2: view

Function for BDH2 Gene

Molecular function for BDH2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=60 uM for NAD {ECO:0000269 PubMed:16380372}; KM=10 mM for R-hydroxybutyrate {ECO:0000269 PubMed:16380372}; Vmax=82 nmol/min/mg enzyme (at 30 degrees Celsius) {ECO:0000269 PubMed:16380372}; pH dependence: Optimum pH is 7.5-9.0. {ECO:0000269 PubMed:16380372};
UniProtKB/Swiss-Prot CatalyticActivity: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH
UniProtKB/Swiss-Prot Function: Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).

Enzyme Numbers (IUBMB) for BDH2 Gene

Gene Ontology (GO) - Molecular Function for BDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003858 3-hydroxybutyrate dehydrogenase activity IDA 16380372
GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity --
GO:0016491 oxidoreductase activity --
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISS --
GO:0051287 NAD binding IDA 16380372
genes like me logo Genes that share ontologies with BDH2: view

Animal Model Products

CRISPR Products

miRNA for BDH2 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BDH2 Gene

Localization for BDH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDH2 Gene


Subcellular locations from

Jensen Localization Image for BDH2 Gene COMPARTMENTS Subcellular localization image for BDH2 gene
Compartment Confidence
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 NOT mitochondrion IDA 16380372
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BDH2: view

Pathways for BDH2 Gene

genes like me logo Genes that share pathways with BDH2: view

Pathways by source for BDH2 Gene

1 BioSystems pathway for BDH2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Fatty Acid Metabolism in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat

UniProtKB/Swiss-Prot Q9BUT1-BDH2_HUMAN

  • Pathway: Siderophore biosynthesis

Interacting Proteins for BDH2 Gene

Gene Ontology (GO) - Biological Process for BDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006635 fatty acid beta-oxidation IDA 16380372
GO:0008152 metabolic process --
GO:0019290 siderophore biosynthetic process ISS --
GO:0030855 epithelial cell differentiation IDA 21492153
GO:0042168 heme metabolic process ISS --
genes like me logo Genes that share ontologies with BDH2: view

Compounds for BDH2 Gene

(6) HMDB Compounds for BDH2 Gene

Compound Synonyms Cas Number PubMed IDs
(R)-3-Hydroxybutyric acid
  • (R)-(-)-b-Hydroxybutyrate
(S)-3-Hydroxybutyric acid
  • (S)-3-hydroxy-Butanoic acid
3-Hydroxybutyric acid
  • 3-OH-butyric acid
Acetoacetic acid
  • 3-Ketobutyrate
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
genes like me logo Genes that share compounds with BDH2: view

Transcripts for BDH2 Gene

Unigene Clusters for BDH2 Gene

3-hydroxybutyrate dehydrogenase, type 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BDH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BDH2 Gene

No ASD Table

Relevant External Links for BDH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BDH2 Gene

mRNA expression in normal human tissues for BDH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BDH2 Gene

SOURCE GeneReport for Unigene cluster for BDH2 Gene Hs.124696

genes like me logo Genes that share expressions with BDH2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BDH2 Gene

Orthologs for BDH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BDH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 85 (a)
-- 36
  • 96 (a)
BDH2 35
  • 99.59 (n)
  • 100 (a)
(Bos Taurus)
Mammalia BDH2 35
  • 89.52 (n)
  • 92.65 (a)
BDH2 36
  • 93 (a)
(Canis familiaris)
Mammalia BDH2 35
  • 90.2 (n)
  • 91.84 (a)
BDH2 36
  • 92 (a)
(Mus musculus)
Mammalia Bdh2 35
  • 85.31 (n)
  • 90.61 (a)
Bdh2 16
Bdh2 36
  • 87 (a)
(Monodelphis domestica)
Mammalia BDH2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia BDH2 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Bdh2 35
  • 86.12 (n)
  • 88.98 (a)
(Gallus gallus)
Aves BDH2 35
  • 76.73 (n)
  • 80 (a)
BDH2 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bdh2 35
  • 74.83 (n)
  • 82.04 (a)
Str.16632 35
(Danio rerio)
Actinopterygii bdh2 35
  • 72.79 (n)
  • 76.33 (a)
bdh2 36
  • 76 (a)
Dr.15584 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26760 35
  • 45.94 (n)
  • 35.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02480 35
  • 48.37 (n)
  • 37.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for BDH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDH2 Gene

Gene Tree for BDH2 (if available)
Gene Tree for BDH2 (if available)

Paralogs for BDH2 Gene

Selected SIMAP similar genes for BDH2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BDH2: view

Variants for BDH2 Gene

Sequence variations from dbSNP and Humsavar for BDH2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs736048 -- 103,089,338(+) TTAGG(A/G)GCAGG intron-variant
rs746829 -- 103,089,910(-) AGTGC(C/T)TAGAA intron-variant
rs1054707 - 103,092,639(-) TGCCA(A/G)TGAAG reference, missense
rs1062018 -- 103,085,924(-) ACAAT(A/C)TGGCA intron-variant
rs2069274 -- 103,099,624(-) TCTGT(C/G)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BDH2 Gene

Variant ID Type Subtype PubMed ID
dgv1656e1 CNV Complex 17122850
nsv830021 CNV Loss 17160897

Relevant External Links for BDH2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDH2 Gene

Disorders for BDH2 Gene

Relevant External Links for BDH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BDH2: view

No data available for UniProtKB/Swiss-Prot for BDH2 Gene

Publications for BDH2 Gene

  1. Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta- hydroxybutyrate dehydrogenase. (PMID: 16380372) Guo K. … Oppermann U. (J. Biol. Chem. 2006) 2 3 4
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for BDH2 Gene

  • Addgene plasmids for BDH2

Sources for BDH2 Gene

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