BCRP3 Gene

Aliases
for BCRP3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Summaries
for BCRP3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for BCRP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000022.10  NC_018933.2  NT_011520.13  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCRP3

BCRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P025030:  view genomic region     (about GC identifiers)

Proteins
for BCRP3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Domains /
Families
for BCRP3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

Function
for BCRP3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Localization
for BCRP3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Pathways & Interactions
for BCRP3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Drugs & Compounds
for BCRP3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for BCRP3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Unigene Cluster for BCRP3:

miRNA Products:		Block miRNA regulation of human, mouse, rat BCRP3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate BCRP3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse OriGene RNAi
		Predesigned siRNA for gene silencing in human, mouse, rat BCRP3

Clone Products:		Browse OriGene untagged/tagged cDNA clones in CMV expression vector OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for BCRP3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCRP3
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BCRP3

Primer Products:		Browse OriGene qPCR
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat BCRP3
		QuantiTect SYBR Green Assays in human, mouse, rat BCRP3
		QuantiFast Probe-based Assays in human, mouse, rat BCRP3

Additional mRNA sequence: 

6 DOTS entries:

Expression
for BCRP3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCRP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCACTTGGTG

About this image

Primer Products:		Browse OriGene qPCR
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat BCRP3
		QuantiTect SYBR Green Assays in human, mouse, rat BCRP3
		QuantiFast Probe-based Assays in human, mouse, rat BCRP3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCRP3

Orthologs
for BCRP3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for BCRP3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Genomic Variants
for BCRP3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for BCRP3 (see all 390)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs2015871031,2	C	--	25026900(+)	CTTATC/GTCAAC	1	--	us2k1		0	--	--	--	--
rs1899196641,2		--	25026968(+)	GTGTCG/TGGCTG	1	--	us2k1		0	--	--	--	--
rs60042091,2	C	--	25026980(+)	ggaacG/Agtcag	1	--	us2k1		1		NA	2
rs59967251,2	F	--	25027002(+)	CCCACA/GAGGCC	1	--	us2k1		1		NA	2
rs60042111,2	C	--	25027097(+)	TTGTGC/TCCCTG	1	--	us2k1		0	--	--	--	--
rs1417503731,2	C	--	25027104(+)	CCTGCG/TTACTT	1	--	us2k1		0	--	--	--	--
rs608247741,2		--	25027191(+)	GCCCTG/TAATCC	1	--	us2k1		0	--	--	--	--
rs130552061,2	C	--	25027248(+)	TGGGGA/C/GTAGGG	1	--	us2k1		1		NA	2
rs110903291,2	C,A,H	--	25027257(+)	ggttaC/Tagatt	1	--	us2k1		0	--	--	--	--
rs57477341,2	C	--	25027283(-)	aaattA/Cttttg	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for BCRP3 (25028882 - 25049327 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for BCRP3:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2659398	CNV	Deletion	23128226
esv2724068	CNV	Deletion	23290073
esv2724041	CNV	Deletion	23290073
esv2530395	CNV	Loss	19546169
esv25356	CNV	Gain	19812545
nsv9884	CNV	Gain+Loss	18304495
nsv7350	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing BCRP3

DNA2.0 Custom Variant and Variant Library Synthesis for BCRP3

Disorders / Diseases
for BCRP3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for BCRP3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Linear order of the four BCR-related loci in 22q11. (PubMed id 3267213)^{1, 3} Budarf M....Emanuel B.S. (Genomics 1988)
2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
3. The DNA sequence of human chromosome 22. (PubMed id 10591208)¹ Dunham I.... Wright H. (Nature 1999)

External Searches for BCRP3 gene

Genome Databases showing BCRP3 gene

Other Databases showing BCRP3 gene

Specialized Databases showing BCRP3 gene

Products
for BCRP3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section