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BCRP3 Gene

pseudogene GIFtS: 20
GCID: GC22P025030

Breakpoint Cluster Region Pseudogene 3

(Previous names: breakpoint cluster region-like 6, breakpoint cluster region-like...)
(Previous symbols: BCR3, BCRL6, BCRL3)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Breakpoint Cluster Region Pseudogene 3¹ ²
BCRL3¹ ² ⁵
BCR3¹ ²
BCRL6¹ ²
Breakpoint Cluster Region-Like 3¹
Breakpoint Cluster Region-Like 6¹

External Ids:	HGNC: 1016¹	Entrez Gene: 644165²	Ensembl: ENSG00000215481⁷	OMIM: 113640⁵

Export aliases for BCRP3 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BCRP3 Gene:

BCRP3 (breakpoint cluster region pseudogene 3) is a pseudogene.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000022.10 NC_018933.2 NT_011520.13

Regulatory elements:

Search for regulatory transcription factor binding sites for BCRP3
Other transcription factors

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCRP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11

BCRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCRP3 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P025030: view genomic region (about GC identifiers)

Start:	25,028,882 bp from pter	End:	25,049,327 bp from pter
Size:	20,446 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for BCRP3

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for BCRP3
Interactions:

Search GeneGlobe Interaction Network for BCRP3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for BCRP3:

Breakpoint cluster region pseudogene 3

Hs.655234 [show with all ESTs]

Unigene Representative Sequence: AK297038

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382243 ENST00000447261(uc011ajv.2)

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Additional mRNA sequence:

AK297038.1 NR_024494.1

6 DOTS entries:

DT.40272767 DT.99964341 DT.100826983 DT.100826988 DT.102841720 DT.120677784

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BCRP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCACTTGGTG

About this image

BCRP3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

--

SOURCE GeneReport for Unigene cluster: Hs.655234

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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--

ENSEMBL Gene Tree for BCRP3 (if available)
TreeFam Gene Tree for BCRP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201587103^1,2	C	--	25026900(+)	`CTTATC/GTCAAC`	1	--	us2k¹		0	--	--	--	--
rs189919664^1,2		--	25026968(+)	`GTGTCG/TGGCTG`	1	--	us2k¹		0	--	--	--	--
rs6004209^1,2	C	--	25026980(+)	`ggaacG/Agtcag`	1	--	us2k¹		1		NA	2
rs5996725^1,2	F	--	25027002(+)	`CCCACA/GAGGCC`	1	--	us2k¹		1		NA	2
rs6004211^1,2	C	--	25027097(+)	`TTGTGC/TCCCTG`	1	--	us2k¹		0	--	--	--	--
rs141750373^1,2	C	--	25027104(+)	`CCTGCG/TTACTT`	1	--	us2k¹		0	--	--	--	--
rs60824774^1,2		--	25027191(+)	`GCCCTG/TAATCC`	1	--	us2k¹		0	--	--	--	--
rs13055206^1,2	C	--	25027248(+)	`TGGGGA/C/GTAGGG`	1	--	us2k¹		1		NA	2
rs11090329^1,2	C,A,H	--	25027257(+)	`ggttaC/Tagatt`	1	--	us2k¹		0	--	--	--	--
rs5747734^1,2	C	--	25027283(-)	`aaattA/Cttttg`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BCRP3 (25028882 - 25049327 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for BCRP3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2659398	CNV	Deletion	23128226
esv2724068	CNV	Deletion	23290073
esv2724041	CNV	Deletion	23290073
esv2530395	CNV	Loss	19546169
esv25356	CNV	Gain	19812545
nsv9884	CNV	Gain+Loss	18304495
nsv7350	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 113640 OMIM disorders: --

Find genes that share disorders with BCRP3 About GenesLikeMe

Export disorders for BCRP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BCRP3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with BCRP3)

Utopia: connect your pdf to the dynamic
world of online information

Linear order of the four BCR-related loci in 22q11. (PubMed id 3267213)^{1, 3} Budarf M....Emanuel B.S. (Genomics 1988)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
The DNA sequence of human chromosome 22. (PubMed id 10591208)¹ Dunham I.... Wright H. (Nature 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 644165	HGNC: 1016	Ensembl:ENSG00000215481	euGenes: HUgn644165	ECgene: BCRP3
H-InvDB: BCRP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Intellectual Property for BCRP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BCRP3 gene:
Search GeneIP for patents involving BCRP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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BCRP3 Gene

Breakpoint Cluster Region Pseudogene 3

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Breakpoint Cluster Region Pseudogene 3

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