BCR Gene
protein-coding GIFtS: 70
GCID: GC22P023521
|
|
breakpoint cluster region
(Previous symbols: D22S11, BCR1)
| |
Aliases
for BCR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Breakpoint Cluster Region1 2 | | D22S6621 2 | | BCR11 2 3 | | Renal Carcinoma Antigen NY-REN-262 3 | | D22S111 2 3 | | EC 2.7.11.13 8 | | ALL1 2 5 | | BCR/FGFR1 Chimera Protein2 | | CML1 2 5 | | Breakpoint Cluster Region Protein2 | | PHL1 2 5 | | FGFR1/BCR Chimera Protein2 |
Export aliases for BCR gene to outside databasesPrevious GC identifers: GC22P020221 GC22P021847 GC22P021822 GC22P006461 |
Summaries
for BCR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BCR:
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found inpatients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within theBCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene atthe chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of thenormal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activatingprotein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BCR_HUMAN, P11274Function: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, therebyactivating them. Displays serine/threonine kinase activity
Gene Wiki entry for BCR (BCR gene)
|
Genomic Views
for BCR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BCR gene promoter:
AREB6 p53 HOXA5 HSF1short HSF1 (long) POU6F1 (c2) NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BCR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11BCR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P023521: view genomic region
(about GC identifiers)
Start:
|
23,521,891 bp from pter |
End:
|
23,660,224 bp from pter |
Size:
|
138,334 bases |
Orientation:
|
plus strand |
|
Proteins
for BCR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BCR_HUMAN, P11274 (See
protein sequence)Recommended Name: Breakpoint cluster region protein Size: 1271 amino acids; 142819 Da
Subunit: Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1,PIK3R1 and GRB2. Interacts with HCK
Sequence caution: Sequence=BAE06073.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for BCR:1K1F (3D)
2AIN (3D)
Secondary accessions: P78501 Q12842 Q4LE80 Q6NZI3Alternative splicing: 2 isoforms: P11274-1 P11274-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BCR: NX_P11274
Post-translational modifications:
Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinaseactivity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P11274
3 DME Specific Peptides for BCR (P11274)
BCR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004318.3 NP_067585.2
ENSEMBL proteins: ENSP00000303507 ENSP00000352535 ENSP00000396531 ENSP00000381524 Reactome Protein details: P11274
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
BCR for ontologies About GeneDecksing
BCR Antibody Products:
Assay Products for BCR: |
Protein
Domains /
Families
for BCR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BCR for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry P11274ProtoNet protein and cluster: P11274 4 Blocks protein families: IPB000008 C2 domain IPB000198 RhoGAP domain IPB000219 DH domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: BCR_HUMAN, P11274Domain: The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thrphosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase andtransforming potential of the chimeric BCR-ABL oncogeneDomain: The DH domain is involved in interaction with CCPG1 (By similarity)Similarity: Contains 1 C2 domainSimilarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 Rho-GAP domain |
Function
for BCR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BCR_HUMAN, P11274Function: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, therebyactivating them. Displays serine/threonine kinase activityCatalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for BCR:breakpoint cluster region
Enzyme Number (IUBMB): EC 2.7.11.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BCR (NM_021574) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCR | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BCR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCR |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
BCR for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for BCR:
Animal Models:
Mouse knock-out Bcrtm1Hkp for BCR
12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bcr):
BCR for phenotypes About GeneDecksing
|
Pathways & Interactions
for BCR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling Regulation of RAC1 activity | | | 2 | G-protein signaling TC21 regulation pathway | | | 3 | Signaling by FGFR1 mutants | | | 4 | G-protein signaling K-RAS regulation pathway | | | 5 | Cell death signalling via NRAGE, NRIF and NADE | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for BCR (see all 6)
1 
Cell Signaling Technology (CST) Pathway for BCR
5/6  GeneGo (Thomson Reuters) Pathways for BCR (see all 6)
2  BioSystems Pathways for BCR
5/9 
Reactome Pathways for BCR (see all 9)
1  PharmGKB Pathway for BCR
2 
Kegg Pathways (Kegg details for BCR):
BCR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/133 Interacting proteins for BCR (P112741, 2, 3 ENSP000003035074) via UniProtKB, MINT, STRING, and/or I2D (see all 133)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GRB2 | P629932, 3, ENSP000003390074 | MINT-8026563 MINT-8026477 MINT-8026578 MINT-8026593 MINT-8026462 MINT-8026548 MINT-8026507 MINT-8026492 MINT-8026533 I2D:
score=5 STRING: ENSP00000339007 | | CFTR | P135692, 3, ENSP000000030844 | MINT-69537 I2D:
score=2 STRING: ENSP00000003084 | | ATP2B1 | P200202, 3, ENSP000002611734 | MINT-69534 I2D:
score=1 STRING: ENSP00000261173 | | GRAP | Q135882, 3, ENSP000002841544 | MINT-8026518 I2D:
score=1 STRING: ENSP00000284154 | | RGS12 | O149242, 3, ENSP000003393814 | MINT-69542 I2D:
score=1 STRING: ENSP00000339381 |
About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table
BCR for ontologies About GeneDecksing
|
Drugs & Compounds
for BCR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BCR for compounds About GeneDecksing
 Browse Tocris compounds for BCR
3 HMDB Compounds for BCR About this table
10/52 Novoseek chemical compound relationships for BCR gene (see all 52) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
80.9 |
439 |
8955135 (6), 10405761 (6), 9178913 (6), 7529874 (5) (see all 99) |
| imatinib |
80.5 |
43 |
12829585 (3), 14635084 (2), 17493325 (2), 18406870 (2) (see all 32) |
| blys |
63.9 |
9 |
17548587 (2), 14962189 (2), 12956429 (2), 18978795 (1) (see all 5) |
| dasatinib |
60.6 |
1 |
18956997 (1) |
| inositol |
49.7 |
15 |
10196207 (2), 9743328 (1), 10617650 (1), 15081531 (1) (see all 14) |
| phosphatidylinositol |
48.8 |
19 |
11823472 (2), 14555967 (1), 8805618 (1), 11345196 (1) (see all 14) |
| phosphotyrosine |
46.2 |
15 |
10442632 (4), 1712671 (2), 8912843 (1), 11809685 (1) (see all 7) |
| inositol 1,4,5 trisphosphate |
42.1 |
8 |
9565626 (2), 10327049 (1), 20224233 (1), 14558886 (1) (see all 7) |
| bgl ii |
34.8 |
2 |
8632666 (1), 11672777 (1) |
| phosphoinositide |
34.2 |
8 |
9139721 (1), 12077122 (1), 12524457 (1), 9252119 (1) (see all 8) |
2 PharmGKB related drug/compound annotations for BCR geneAbout this table
Search CenterWatch for drugs/clinical trials and news about BCR
|
Transcripts
for BCR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BCR gene (2 alternative transcripts): NM_004327.3 NM_021574.2 Unigene Clusters for BCR: Breakpoint cluster region Hs.517461 [show with all ESTs], Hs.715409 Unigene Representative Sequences: NM_004327, BC07174216 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479188 ENST00000305877(uc002zww.3 uc002zwx.3 uc011aiy.2)
ENST00000359540(uc010gtx.1) ENST00000463770 ENST00000487679 ENST00000480973
ENST00000427791 ENST00000487968(uc002zwy.2) ENST00000466076 ENST00000419722
ENST00000471452 ENST00000478978 ENST00000475025 ENST00000436990 ENST00000458056
ENST00000398512
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BCR (NM_021574) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCR | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BCR |
Additional cDNA sequence: BC071742.1 24/37 DOTS entries (see all 37): DT.115766 DT.100826988 DT.86995909 DT.100826985 DT.102841720 DT.120677584 DT.95354641 DT.102841710 DT.120677784 DT.120676864 DT.100826990 DT.97836027 DT.92006114 DT.106787 DT.120677442 DT.100038569 DT.121201744 DT.91761972 DT.91761973 DT.92031691 DT.100826986 DT.120642698 DT.120677236 DT.120677378 24/127 AceView cDNA sequences (see all 127): CB144645 BC031568 BQ709937 BU196996 BQ691951 CR623143 AY536250 H55699 BQ422888 BX489609 AA371833 BE315159 BM454840 H55545 BE739832 BM910362 BF873836 H55543 H55528 BQ945725 BV198213 BQ227532 BE615094 BE267891
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BCR (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BCR
|
Expression
for BCR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BCR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTAAAAGT
About this image
See BCR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCR
SOURCE GeneReport for Unigene clusters: Hs.517461 Hs.715409
SABiosciences Expression via Pathway-Focused PCR Arrays including BCR:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCR |
Orthologs
for BCR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BCR gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BCR1 |
breakpoint cluster region |
77.89(n)
87.25(a) |
|
416952 XM_415244.3 XP_415244.3 |
lizard
(Anolis carolinensis) |
Reptilia |
BCR6 |
-- |
79(a) |
1 ↔ 1 |
GL343947.1(27833-38018) |
zebrafish
(Danio rerio) |
Actinopterygii |
bcr1 |
breakpoint cluster region |
72(n)
78.98(a) |
|
568320 XM_002665937.1 XP_002665983.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RhoGAP1A3 |
GTPase activator |
35(a) |
|
1A -- |
ENSEMBL Gene Tree for BCR (if available)
TreeFam Gene Tree for BCR (if available) |
Paralogs
for BCR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BCR gene
- RACGAP12 SYDE22 ABR2 SYDE12
11 SIMAP similar genes for BCR using alignment to 13 protein entries: BCR_HUMAN (see all proteins):BCR/ABL1 fusion FLJ00077 BCR-ABL fusion BCR/ABL fusion BCR-ABL1 BCR-ABL1 e19a2
FBXW4 ABR ARHGAP12 CHN1 ARHGAP9
BCR for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for BCR (see all 8)
PGOHUM00000248620 PGOHUM00000246224 PGOHUM00000246249 PGOHUM00000259691 PGOHUM00000246290
|
Genomic Variants
for BCR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BCR (23521891 - 23660224 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for BCR
6 CNVs: 73778 31074 90955 79495 73777 32451
1 Indel: 67851
Human Gene Mutation Database (HGMD): BCR
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCR |
|
Disorders
/ Diseases
for BCR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BCR for disorders About GeneDecksing
OMIM gene information: 151410
OMIM disorders: 608232 613065
UniProtKB/Swiss-Prot: BCR_HUMAN, P11274
Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocationt(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acutelymphoblastic leukemia (ALL)
20/80  diseases for BCR (see all 80): About MalaCardsphiladelphia-negative chronic myeloid leukemia leukemia splenic marginal zone lymphoma xeroderma pigmentosum
xeroderma pigmentosum, group b renal carcinoma diffuse large b-cell lymphoma hypersensitivity reaction type ii disease
central nervous system lymphoma gastrointestinal stromal tumor b-cell lymphomas anaplastic large cell lymphoma
pilomyxoid astrocytoma myeloproliferative disorder non-hodgkin lymphoma myeloid leukemia
carcinoma polycythemia vera chronic myeloid leukemia lymphoblastic leukemia
2 diseases from the University of Copenhagen DISEASES database for BCR:Leukemia Bone marrow cancer 10/63 Novoseek disease relationships for BCR gene (see all 63) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| myeloid leukemia chronic |
91.4 |
161 |
12011769 (2), 2403827 (2), 7512367 (2), 2337672 (2) (see all 99) |
| blast crisis |
81.5 |
12 |
7683349 (3), 2337672 (3), 1961034 (1), 1427440 (1) (see all 8) |
| leukemia |
75.3 |
122 |
8435337 (4), 9341866 (3), 7513545 (2), 1961034 (2) (see all 94) |
| philadelphia chromosome positive chronic myelogenous leukemia |
70.8 |
1 |
17604501 (1) |
| leukemia lymphocytic chronic |
69.2 |
14 |
17928528 (1), 17003377 (1), 9369427 (1), 15057307 (1) (see all 14) |
| lymphoblastic leukemia acute |
69 |
26 |
2145450 (2), 1705008 (1), 8426467 (1), 11369654 (1) (see all 23) |
| myeloproliferative disorders |
67.9 |
9 |
8818385 (2), 19394693 (1), 19936007 (1), 10490629 (1) (see all 6) |
| lymphocytic leukemia chronic b-cell |
64.4 |
5 |
16616061 (1), 9049959 (1), 19074730 (1), 15591116 (1) (see all 5) |
| burkitt lymphoma |
59.4 |
12 |
10438726 (2), 11027651 (2), 9233773 (1), 9533441 (1) (see all 10) |
| leukemia b-cell |
56.1 |
1 |
19074730 (1) |
Genetic Association Database (GAD): BCR
Human Genome Epidemiology (HuGE) Navigator: BCR (207 documents)
Tumor Gene Database (TGDB): BCR
Export disorders for BCR gene to outside databases
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Publications
for BCR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for BCR gene, integrated from 9 sources (see all 998):
(articles sorted by number of sources associating them with BCR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The BCR gene encodes a novel serine/threonine kinase activity within a single exon. (PubMed id 1657398)1, 2, 3, 9 Maru Y. and Witte O.N. (1991)
- Characterization of the BCR promoter in Philadelphia chromosome- positive and -negative cell lines. (PubMed id 1900918)1, 2, 9 Shah N.P.... Denny C.T. (1991)
- Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. (PubMed id 7665185)1, 2, 9 Chissoe S.L.... Roe B.A. (1995)
- BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine- dependent manner. (PubMed id 1712671)1, 2, 9 Pendergast A.M.... Witte O.N. (1991)
- Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. (PubMed id 15494376)1, 2, 9 Malmberg E.K.... Riordan J.R. (2004)
- [Polymorphism analysis of 5' promotor region of BCR gene] (PubMed id 15248918)1, 4, 9 Tian H....Zhou S.Y. (2004)
- Bcr encodes a GTPase-activating protein for p21rac. (PubMed id 1903516)1, 2, 9 Diekmann D.... Hall A. (1991)
- Activity of the Bcr GTPase-activating domain is regul ated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor. (PubMed id 18070886)1, 3 Kweon S.M....Heisterkamp N. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- [Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia] (PubMed id 15968309)1, 4 Zhu Y.L....Liu J. (2005)
|
External Searches for BCR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing BCR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing BCR gene
(According to HUGE)
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Specialized Databases showing BCR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for BCR gene:
Search GeneIP for patents involving BCR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for BCR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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| | |  | OriGene Antibodies for BCR | | OriGene shRNA RFP for BCR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCR | | | OriGene Protein Over-expression Lysate for BCR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BCR | | OriGene 3'-UTR Clone for BCR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BCR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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