Aliases for BCR Gene
External Ids for BCR Gene
Previous HGNC Symbols for BCR Gene
Previous GeneCards Identifiers for BCR Gene
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCR Gene
BCR (BCR, RhoGEF And GTPase Activating Protein) is a Protein Coding gene. Diseases associated with BCR include Leukemia, Chronic Myeloid, Somatic and Leukemia, Acute Lymphoblastic. Among its related pathways are G-protein signaling_H-RAS regulation pathway and FGFR1 mutant receptor activation. GO annotations related to this gene include protein tyrosine kinase activity and enzyme binding. An important paralog of this gene is ABR.
UniProtKB/Swiss-Prot for BCR Gene
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.