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Aliases for BCR Gene

Aliases for BCR Gene

  • Breakpoint Cluster Region 2 3
  • Renal Carcinoma Antigen NY-REN-26 3 4
  • EC 2.7.11.1 4 63
  • D22S11 3 4
  • BCR1 3 4
  • ALL 3 6
  • CML 3 6
  • PHL 3 6
  • Breakpoint Cluster Region Protein 3
  • BCR/FGFR1 Chimera Protein 3
  • FGFR1/BCR Chimera Protein 3
  • D22S662 3

External Ids for BCR Gene

Previous HGNC Symbols for BCR Gene

  • D22S11
  • BCR1

Previous GeneCards Identifiers for BCR Gene

  • GC22P020221
  • GC22P021847
  • GC22P021822
  • GC22P023521
  • GC22P006461

Summaries for BCR Gene

Entrez Gene Summary for BCR Gene

  • A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCR Gene

BCR (Breakpoint Cluster Region) is a Protein Coding gene. Diseases associated with BCR include leukemia, chronic myeloid and leukemia, acute lymphoblastic. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. GO annotations related to this gene include protein serine/threonine kinase activity and enzyme binding. An important paralog of this gene is ABR.

UniProtKB/Swiss-Prot for BCR Gene

  • GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Gene Wiki entry for BCR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCR Gene

Genomics for BCR Gene

Regulatory Elements for BCR Gene

Genomic Location for BCR Gene

Start:
23,179,704 bp from pter
End:
23,318,037 bp from pter
Size:
138,334 bases
Orientation:
Plus strand

Genomic View for BCR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCR Gene

Proteins for BCR Gene

  • Protein details for BCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11274-BCR_HUMAN
    Recommended name:
    Breakpoint cluster region protein
    Protein Accession:
    P11274
    Secondary Accessions:
    • P78501
    • Q12842
    • Q4LE80
    • Q6NZI3

    Protein attributes for BCR Gene

    Size:
    1271 amino acids
    Molecular mass:
    142819 Da
    Quaternary structure:
    • Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK. Interacts with SH2D5 (PubMed:25331951).
    SequenceCaution:
    • Sequence=BAE06073.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCR Gene

    Alternative splice isoforms for BCR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCR Gene

Proteomics data for BCR Gene at MOPED

Selected DME Specific Peptides for BCR Gene

Post-translational modifications for BCR Gene

  • Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCR (Bcr)

Domains for BCR Gene

Gene Families for BCR Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Graphical View of Domain Structure for InterPro Entry

P11274

UniProtKB/Swiss-Prot:

BCR_HUMAN :
  • P11274
Domain:
  • The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene
  • The DH domain is involved in interaction with CCPG1.
  • Contains 1 C2 domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with BCR: view

Function for BCR Gene

Molecular function for BCR Gene

GENATLAS Biochemistry:
breakpoint cluster region
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Enzyme Numbers (IUBMB) for BCR Gene

Gene Ontology (GO) - Molecular Function for BCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 10887132
genes like me logo Genes that share ontologies with BCR: view
genes like me logo Genes that share phenotypes with BCR: view

Animal Models for BCR Gene

MGI Knock Outs for BCR:

Animal Model Products

miRNA for BCR Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCR

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for BCR Gene

Localization for BCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCR Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCR Gene COMPARTMENTS Subcellular localization image for BCR gene
Compartment Confidence
cytosol 4
cytoskeleton 2
endosome 2
extracellular 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane --
GO:0014069 postsynaptic density ISS --
genes like me logo Genes that share ontologies with BCR: view

Pathways for BCR Gene

genes like me logo Genes that share pathways with BCR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 1657398
GO:0007165 signal transduction TAS 1657398
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007420 brain development IEA --
GO:0018108 peptidyl-tyrosine phosphorylation TAS --
genes like me logo Genes that share ontologies with BCR: view

Compounds for BCR Gene

(8) ApexBio Compounds for BCR Gene

Compound Action Cas Number
Bafetinib (INNO-406) Bcr-Abl/Lyn tyrosine kinase inhibitor [887650-05-7]
Bosutinib (SKI-606) Potent Abl/Src kinases [380843-75-4]
DCC-2036 (Rebastinib) Bcr-Abl inhibitor [1020172-07-9]
GNF 2 Bcr-Abl inhibitor [778270-11-4]
GNF 5 Bcr-Abl inhibitor [778277-15-9]
GZD824 "Bcr-Abl inhibitor,novel orally bioavailable" [1421783-64-3]
Nilotinib(AMN-107) "Bcr-Abl kinase inhibitor,selective" [641571-10-0]
PD173955 "Dual Src/Abl kinase inhibitor, ATP-competitive," [260415-63-2]

(3) HMDB Compounds for BCR Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Guanosine triphosphate
  • 5'-GTP
86-01-1

(52) Novoseek inferred chemical compound relationships for BCR Gene

Compound -log(P) Hits PubMed IDs
tyrosine 80.9 187
imatinib 80.5 37
blys 63.9 8
dasatinib 60.6 1
inositol 49.7 15

(7) PharmGKB related drug/compound annotations for BCR Gene

genes like me logo Genes that share compounds with BCR: view

Transcripts for BCR Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6:

Relevant External Links for BCR Gene

GeneLoc Exon Structure for
BCR
ECgene alternative splicing isoforms for
BCR

Expression for BCR Gene

mRNA expression in normal human tissues for BCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BCR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Cervix (7.7), Placenta (7.2), and Frontal cortex (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCR Gene

SOURCE GeneReport for Unigene cluster for BCR Gene Hs.517461

genes like me logo Genes that share expressions with BCR: view

Expression partners for BCR Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BCR Gene

Orthologs for BCR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BCR Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia BCR 35
  • 90.57 (n)
  • 94.45 (a)
BCR 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcr 35
  • 89.17 (n)
  • 93.85 (a)
Bcr 16
Bcr 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCR 35
  • 99.5 (n)
  • 99.75 (a)
BCR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcr 35
  • 88.07 (n)
  • 92.73 (a)
cow
(Bos Taurus)
Mammalia BCR 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCR 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCR 35
  • 77.73 (n)
  • 86.86 (a)
BCR 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCR 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcr 35
  • 70.43 (n)
  • 77.08 (a)
zebrafish
(Danio rerio)
Actinopterygii bcr 35
  • 72.07 (n)
  • 78.64 (a)
bcr 36
  • 74 (a)
OneToMany
BCR (1 of 2) 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP1A 37
  • 35 (a)
RhoGAP1A 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BEM2 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for BCR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCR Gene

ENSEMBL:
Gene Tree for BCR (if available)
TreeFam:
Gene Tree for BCR (if available)

Paralogs for BCR Gene

Paralogs for BCR Gene

genes like me logo Genes that share paralogs with BCR: view

Variants for BCR Gene

Sequence variations from dbSNP and Humsavar for BCR Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs3680 -- 23,317,788(-) GAGAA(C/T)GCTGC utr-variant-3-prime
rs9155 -- 23,315,694(+) AGATC(C/T)GCCCA utr-variant-3-prime
rs16802 -- 23,290,326(+) CTTTG(A/G)TCTCT intron-variant
rs28375 -- 23,243,124(+) aattt(C/T)ctgaa intron-variant
rs131671 -- 23,252,624(+) TGGGG(-/T)TTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCR Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv4900n71 CNV Gain 21882294
nsv521695 CNV Loss 19592680
nsv9876 CNV Gain+Loss 18304495
dgv749n67 CNV Loss 20364138
esv2724039 CNV Deletion 23290073
esv2665954 CNV Deletion 23128226
esv29702 CNV Loss 19812545
esv994062 CNV Gain 20482838
esv22663 CNV Gain 19812545
nsv914578 CNV Gain 21882294
dgv4903n71 CNV Gain 21882294
esv2724041 CNV Deletion 23290073

Relevant External Links for BCR Gene

HapMap Linkage Disequilibrium report
BCR
Human Gene Mutation Database (HGMD)
BCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCR Gene

Disorders for BCR Gene

(2) OMIM Diseases for BCR Gene (151410)

UniProtKB/Swiss-Prot

BCR_HUMAN
  • Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Note=A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

(4) University of Copenhagen DISEASES for BCR Gene

(63) Novoseek inferred disease relationships for BCR Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia chronic 91.4 108
blast crisis 81.5 12
leukemia 75.3 110
philadelphia chromosome positive chronic myelogenous leukemia 70.8 1
leukemia lymphocytic chronic 69.2 14

Relevant External Links for BCR

Genetic Association Database (GAD)
BCR
Human Genome Epidemiology (HuGE) Navigator
BCR
Tumor Gene Database (TGDB):
BCR
genes like me logo Genes that share disorders with BCR: view

No data available for Genatlas for BCR Gene

Publications for BCR Gene

  1. The BCR gene encodes a novel serine/threonine kinase activity within a single exon. (PMID: 1657398) Maru Y. … Witte O.N. (Cell 1991) 2 3 4 23
  2. Characterization of the BCR promoter in Philadelphia chromosome- positive and -negative cell lines. (PMID: 1900918) Shah N.P. … Denny C.T. (Mol. Cell. Biol. 1991) 3 4 23
  3. Bcr encodes a GTPase-activating protein for p21rac. (PMID: 1903516) Diekmann D. … Hall A. (Nature 1991) 3 4 23
  4. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine- dependent manner. (PMID: 1712671) Pendergast A.M. … Witte O.N. (Cell 1991) 3 4 23
  5. Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. (PMID: 7665185) Chissoe S.L. … Roe B.A. (Genomics 1995) 3 4 23

Products for BCR Gene

Sources for BCR Gene

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