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BCR Gene

protein-coding GIFtS: 74

GC22P021822

breakpoint cluster region
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: D22S11, BCR1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALL ^¹, ², ⁵
BCR1 ^², ³
CML ^¹, ², ⁵
D22S11 ^², ³
D22S662 ^¹, ²
EC 2.7.11.1 ^³
FLJ16453 ^²
PHL ^¹, ², ⁵

Descriptions
Renal carcinoma antigen NY-REN-26 ^³
breakpoint cluster region ^²

External Ids
HGNC: 1014¹
Entrez Gene: 613²
UniProtKB: P11274³
Ensembl: ENSG00000186716⁷

Search outside databases for aliases for BCR gene

Previous GC identifers: GC22P020221 GC22P021847

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BCR:

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which

is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for

this translocation is located within the BCR gene. The translocation produces a fusion protein

which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint.

Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR

gene product is not clear. The protein has serine/threonine kinase activity and is a

GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have

been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: BCR_HUMAN, P11274

Function: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound

GDP by GTP, thereby activating them. Displays serine/threonine kinase activity

Gene Wiki entry for BCR (BCR_gene)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BCR gene

Entrez Gene cytogenetic band: 22q11|22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11

BCR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P021822: (about GC identifiers)

Start:	21,852,552 bp from pter
End:	21,990,224 bp from pter
Size:	137,673 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BCR_HUMAN, P11274 (See protein sequence)

Recommended Name: Breakpoint cluster region protein

Size: 1271 amino acids; 142819 Da

Subunit: Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity)

PDB structure from and Proteopedia :

1K1F (3D)

2AIN (3D)

Secondary accessions: P78501 Q12842 Q4LE80 Q6NZI3

Alternative splicing: 2 isoforms: P11274-1 P11274-2

Post-translational modifications:

Autophosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004318.3 NP_067585.2

ENSEMBL proteins:

ENSP00000335450 ENSP00000381524 ENSP00000292697 ENSP00000290956 ENSP00000352535 ENSP00000303507

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bcr)
	Human Recombinant Proteins from Abnova (BCR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

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Antibodies for BCR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for BCR
	Cell Signaling Technology (CST) Antibodies for BCR
	Antibodies from Abcam (Bcr), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BCR)
	Novus Biologicals Antibodies for BCR

Assays for BCR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11274

ProtoNet protein and cluster: P11274

4 Blocks protein families:

IPB000008 C2 domain

IPB000198 RhoGAP domain

IPB000219 DH domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: BCR_HUMAN, P11274

Domain: The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to

be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the

ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene

Domain: The DH domain is involved in interaction with CCPG1 (By similarity)

Similarity: Contains 1 C2 domain

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 Rho-GAP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021574

Applied Biosystems Silencer® siRNAs for BCR

Sigma-Aldrich siRNA and siRNA Panels for BCR

Sigma-Aldrich shRNA Panels and shRNA for BCR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004327
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004327
untagged cDNA clones in CMV expression vector (see all 2): NM_004327

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004327

UniProtKB/Swiss-Prot: BCR_HUMAN, P11274

Function: GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound

GDP by GTP, thereby activating them. Displays serine/threonine kinase activity

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for BCR:

breakpoint cluster region

11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bcr):

behavior/neurological	digestive/alimentary	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	liver/biliary system	nervous system
renal/urinary system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	TAS	1657398
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005096	GTPase activator activity	TAS	1903516
GO:0016301	kinase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for BCR

5/132 Interacting proteins for BCR (ENSP00000303507³ P11274²) via UniProtKB, MINT, and/or STRING (see all 132 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBA3	O96018²	STRING (score=.71) MINT-69545 MINT-69538 MINT-69541 MINT-69543 MINT-69544
CFTR	P13569²	STRING (score=.793) MINT-69537
MLLT4	P55196²	STRING (score=.897) MINT-4961172
PDZK1	Q5T2W1²	MINT-69532 MINT-69529 MINT-69530 MINT-69531 MINT-69533
PTPN1	P18031²	MINT-6762657 MINT-6762620

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	1657398
GO:0007242	intracellular signaling cascade	IEA	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BCR
10/33 Novoseek chemical compound relationships for BCR gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	80.55	412	8955135 (6), 10405761 (6), 9178913 (6), 7529874 (5) (see all 99)
blys	65.42	9	17548587 (2), 14962189 (2), 12956429 (2), 18978795 (1) (see all 5)
phosphatidylinositol	50.48	19	11823472 (2), 14555967 (1), 8805618 (1), 11345196 (1) (see all 14)
phosphotyrosine	44.28	15	10442632 (4), 1712671 (2), 8912843 (1), 11809685 (1) (see all 7)
inositol 1,4,5 trisphosphate	39.19	7	9565626 (2), 10327049 (1), 14558886 (1), 15284241 (1) (see all 6)
phosphoinositide	36.23	8	9139721 (1), 12077122 (1), 12524457 (1), 9252119 (1) (see all 8)
bgl ii	36.13	2	8632666 (1), 11672777 (1)
threonine	35.43	26	9467953 (3), 8622703 (3), 10900006 (2), 16648854 (1) (see all 14)
calcium	30.76	79	18426802 (4), 9533441 (3), 10196207 (3), 9565626 (2) (see all 46)
benzoyl-coa	29.15	2	16116275 (1), 15721605 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_021574

Sigma-Aldrich siRNA and siRNA Panels for BCR

Sigma-Aldrich shRNA Panels and shRNA for BCR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004327 NM_021574

REFSEQ mRNAs for BCR gene (2 alternative transcripts):

NM_004327.3 NM_021574.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004327 NM_021574

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004327
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004327
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004327

Additional cDNA sequence: BC071742.1

24/36 DOTS entries (see all 36 ):

DT.115766 DT.100826988 DT.86995909 DT.100826985 DT.102841720 DT.120677584 DT.95184998 DT.95354641

DT.102841710 DT.120677784 DT.120676864 DT.100826990 DT.97836027 DT.92006114 DT.106787 DT.120677442

DT.100038569 DT.121201744 DT.91732517 DT.91761972 DT.91761973 DT.92031691 DT.95086271 DT.100826986

24/127 AceView cDNA sequences (see all 127 ):

BE315159 BF873836 BC031568 BE739832 H55528 BM910362 BX489609 BQ709937

AA371833 BQ422888 BU196996 CR623143 BM454840 CB144645 H55545 BQ691951

H55543 AY536250 H55699 AY536248 BE272823 F06286 BQ441890 AK124310

highest scoring ESTs for BCR:

R54450 X02596 AA126020 AA284789 AA419342 AA594249 AA594310 AA633478 AA776955 AI015232

Unigene Clusters for BCR:

Breakpoint cluster region

Hs.517461 [show with all ESTs], Hs.715409 [show with all ESTs]

Unigene Representative Sequences: NM_004327, BC071742

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BCR (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15	^	16
SP1:																													-
SP2:					-		-
SP3:																					-								-
SP4:
SP5:			-				-

About this scheme

ECgene alternative splicing isoforms for BCR

6 Ensembl transcripts including schematic representations:

ENST00000334149 ENST00000398512 ENST00000292697 ENST00000290956 ENST00000359540 ENST00000305877

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BCR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCR

¹ / ² / ³

17 probe-sets matching BCR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1339_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.26	0.76	X14675	0.40	1.00	0.76	1
2043_s_at²^{, 3}	U95-A	2	1.00	0.81	0.05	0.58	M15025	0.20	1.00	0.72	1
34679_at²^{, 3}	U95-A	4	1.00	0.67	0.68	1.15	U07000	0.20	0.50	0.38	1
74612_s_at²^{, 3}	U95-D	4	1.00	0.62	0.94	1.44	R54450	1.00	1.00	1.00	1
91641_g_at²^{, 3}	U95-E	2	1.00	0.53	0.63	1.07	H09896	0.80	0.57	0.69	1
1333_f_at²^{, 3}	U95-A	11	1.00	0.43	0.91	0.77	X02596	1.00	0.87	0.94	1
537_f_at²^{, 3}	U95-A	11	1.00	0.38	0.93	0.76	U07000	0.20	0.50	0.38	1
68350_s_at²^{, 3}	U95-D	7	1.00	0.37	0.78	1.38	AI589365	0.40	0.75	0.60	1
754_s_at²^{, 3}	U95-A	4	1.00	0.29	0.89	0.84	D87002	0.20	0.04	0.14	1
91639_at²^{, 3}	U95-E	5	1.00	0.28	0.91	1.05	H09896	0.80	0.57	0.69	1
64904_at²^{, 3}	U95-C	6	0.50	0.17	0.88	1.24	AL041418	0.20	0.06	0.15	3
202315_s_at²^{, 3}	U133-A	4	1.00	0.56	--	--	NM_004327	0.60	1.00	0.82	1
226602_s_at²^{, 3}	U133-B	6	1.00	0.18	--	--	T30183	0.60	0.83	0.73	1
217223_s_at²^{, 3}	U133-A	11	1.00	0.17	--	--	U07000	0.20	0.50	0.38	1
202315_s_at²	U133Plus2	4	1.00	0.56	--	--	--	--	--	--	--
226602_s_at²	U133Plus2	6	1.00	0.18	--	--	--	--	--	--	--
217223_s_at²	U133Plus2	11	1.00	0.17	--	--	--	--	--	--	--

GeneDecks BCR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.517461 Hs.715409
Expression variation in blood from EXPOLDB for BCR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BCR gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCR¹	--	breakpoint cluster region	90.94(n) 94.39(a)	607482 XM_843561.1 XP_848654.1
rat (Rattus norvegicus)	Bcr¹	--	breakpoint cluster region	88.59(n) 93.99(a)	309696 XM_228091.4 XP_228091.4
mouse (Mus musculus)	Bcr^{1, 5}	10 (40.50 cM)⁵	breakpoint cluster region^{1, 5}	89.35(n)¹ 94.16(a)¹	110279¹ NM_001081412.1¹ NP_001074881.1¹ AI561783⁵ AI853148⁵ (see all 16)
chicken (Gallus gallus)	BCR¹	--	breakpoint cluster region	77.87(n) 87.18(a)	416952 XM_415244.2 XP_415244.2
zebrafish (Danio rerio)	si:dkey-83d9.7¹	--	si:dkey-83d9.7	71.96(n) 78.5(a)	568320 XM_691643.2 XP_696735.2

About this table Species with no ortholog for BCR

ENSEMBL Gene Tree for BCR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BCR gene

SYDE2² LOC728468² BCRL4² FLJ42953² ABR² SYDE1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/974 NCBI SNPs in BCR are shown (see all 974 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 321)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3761418^1,2	A,C,F,H	21851094(+)	`CTGGAA/GATCTG`	2	--	ng5¹		6		EA EU WA	1316
	rs140504^1,2	A,C,F,H	21957369(+)	`CAAGAG/ATGACA`	2	S/N	mis¹		17		MN EU EA WA NA	2974
	rs4437065^1,2	C,H	21933648(+)	`CCACAA/CGGAGT`	2	K/T	mis¹ ese³		5		EU EA WA	582
--	rs11558699^1,2	H	21957275(+)	`GCTTCC/TAGATG`	2	Q/X	non¹ ese³		4		EU EA WA	402
--	rs6003540^1,2	A	21851698(+)	`TTGGCC/GGCCCC`	2	--	ng5¹		0	--	--	--	--
--	rs12484731^1,2	C	21957238(+)	`TATGAA/CTGCAA`	2	D/E	mis¹ ese³		0	--	--	--	--
--	rs180823^1,2	A	21989270(+)	`TGGCAA/CCCGCT`	2	--	ut3¹		0	--	--	--	--
--	rs2229038^1,2	O	21964790(+)	`CGCGCG/ATCTAC`	2	I/V	mis¹		1		MN	56
	rs34437269^1,2	F	21853969(+)	`CCCCTG/AGAGTA`	2	L/L	syn¹		1		NA	72
	rs35727393^1,2	F	21957256(+)	`ATTCCG/ACTCAC`	2	P/P	syn¹		1		NA	46

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HapMap Linkage Disequilibrium images for BCR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 151410

UniProtKB/Swiss-Prot: BCR_HUMAN, P11274

A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia (CML)

[MIM:608232]. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found

also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)

10/61 Novoseek disease relationships for BCR gene (see all 61 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	91.54	154	12011769 (2), 2403827 (2), 7512367 (2), 2337672 (2) (see all 99)
blast crisis	81.88	12	7683349 (3), 2337672 (3), 1961034 (1), 1427440 (1) (see all 8)
leukemia	75.49	118	8435337 (4), 9341866 (3), 7513545 (2), 1961034 (2) (see all 90)
philadelphia chromosome positive chronic myelogenous leukemia	71.45	1	17604501 (1)
lymphoblastic leukemia acute	69.59	25	2145450 (2), 1705008 (1), 8426467 (1), 11369654 (1) (see all 22)
myeloproliferative disorders	67.12	8	8818385 (2), 19394693 (1), 11746971 (1), 10490629 (1) (see all 5)
leukemia lymphocytic chronic	65.92	12	17928528 (1), 17003377 (1), 9369427 (1), 15057307 (1) (see all 12)
lymphocytic leukemia chronic b-cell	60.65	5	16616061 (1), 9049959 (1), 19074730 (1), 15591116 (1) (see all 5)
burkitt lymphoma	60.23	12	10438726 (2), 11027651 (2), 9233773 (1), 9533441 (1) (see all 10)
x-linked agammaglobulinemia	56.76	2	15466623 (1), 10201980 (1)

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Human Gene Mutation Database: BCR
Genetic Association Database: BCR
Human Genome Epidemiology Navigator: BCR (144 documents)
Tumor Gene Database: BCR

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/848 PubMed articles for BCR gene (see all 848 ):

The BCR gene encodes a novel serine/threonine kinase activity within a single exon. (PubMed id 1657398)^{1, 2, 3, 4} Maru Y. and Witte O.N. (1991)
Characterization of the BCR promoter in Philadelphia chromosome- positive and -negative cell lines. (PubMed id 1900918)^{1, 3, 4} Shah N.P.... Denny C.T. (1991)
Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. (PubMed id 7665185)^{1, 3, 4} Chissoe S.L.... Roe B.A. (1995)
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine- dependent manner. (PubMed id 1712671)^{1, 3, 4} Pendergast A.M.... Witte O.N. (1991)
Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. (PubMed id 15494376)^{1, 3, 4} Malmberg E.K.... Riordan J.R. (2004)
[Polymorphism analysis of 5' promotor region of BCR gene] (PubMed id 15248918)^{1, 3, 6} Tian H....Zhou S.Y. (2004)
Bcr encodes a GTPase-activating protein for p21rac. (PubMed id 1903516)^{1, 3, 4} Diekmann D.... Hall A. (1991)
Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor. (PubMed id 18070886)^{2, 3} Kweon S.M....Heisterkamp N. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
[Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia] (PubMed id 15968309)^{3, 6} Zhu Y.L....Liu J. (2005)

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Entrez Gene: 613	HGNC: 1014	AceView: BCR	Ensembl:ENSG00000186716	euGenes: HUgn613
ECgene: BCR	H-InvDB: BCR

(According to HUGE)
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BCR Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for BCR

Summaries
for BCR

Genomic Location
for BCR

Proteins
for BCR

Protein Domains/
Families
for BCR

Gene Function
for BCR

Pathways & Interactions
for BCR

Drugs & Compounds
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BCR Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor BCR

Summariesfor BCR

Genomic Locationfor BCR

Proteinsfor BCR

Protein Domains/Familiesfor BCR

Gene Functionfor BCR

Pathways & Interactionsfor BCR

Drugs & Compoundsfor BCR

Transcriptsfor BCR

Expression for BCR

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Medical Newsfor BCR

Publicationsfor BCR

Search for BCR

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Servicesfor BCR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BCR

Summaries
for BCR

Genomic Location
for BCR

Proteins
for BCR

Protein Domains/
Families
for BCR

Gene Function
for BCR

Pathways & Interactions
for BCR

Drugs & Compounds
for BCR

Transcripts
for BCR

Expression
for BCR

Orthologs
for BCR

Paralogs
for BCR

SNPs/Variants
for BCR

Disorders & Mutations
for BCR

Medical News
for BCR

Publications
for BCR

Licensable Technologies
for BCR

Services
for BCR