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Aliases for BCORL1 Gene

Aliases for BCORL1 Gene

  • BCL6 Corepressor-Like 1 2 3 5
  • BCoR-Like Protein 1 3 4
  • BCoR-L1 3 4
  • Chromosome X Open Reading Frame 10 2
  • BCL6 Co-Repressor-Like 1 2
  • CXorf10 3

External Ids for BCORL1 Gene

Previous HGNC Symbols for BCORL1 Gene

  • CXorf10

Previous GeneCards Identifiers for BCORL1 Gene

  • GC0XP128842
  • GC0XP128944
  • GC0XP129115
  • GC0XP118537

Summaries for BCORL1 Gene

Entrez Gene Summary for BCORL1 Gene

  • The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for BCORL1 Gene

BCORL1 (BCL6 Corepressor-Like 1) is a Protein Coding gene. An important paralog of this gene is ANKRD12.

UniProtKB/Swiss-Prot for BCORL1 Gene

  • Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCORL1 Gene

Genomics for BCORL1 Gene

Regulatory Elements for BCORL1 Gene

Genomic Location for BCORL1 Gene

Chromosome:
X
Start:
129,980,283 bp from pter
End:
130,058,083 bp from pter
Size:
77,801 bases
Orientation:
Plus strand

Genomic View for BCORL1 Gene

Genes around BCORL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCORL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCORL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCORL1 Gene

Proteins for BCORL1 Gene

  • Protein details for BCORL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9F3-BCORL_HUMAN
    Recommended name:
    BCL-6 corepressor-like protein 1
    Protein Accession:
    Q5H9F3
    Secondary Accessions:
    • B5MDQ8
    • Q5H9F2
    • Q5H9F4
    • Q6ZVE0
    • Q8TEN3
    • Q9Y528

    Protein attributes for BCORL1 Gene

    Size:
    1711 amino acids
    Molecular mass:
    182526 Da
    Quaternary structure:
    • Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7. Interacts with PCGF1; the interaction is direct.
    SequenceCaution:
    • Sequence=BAC85922.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCORL1 Gene

    Alternative splice isoforms for BCORL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCORL1 Gene

Proteomics data for BCORL1 Gene at MOPED

Post-translational modifications for BCORL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCORL1 Gene

No data available for DME Specific Peptides for BCORL1 Gene

Domains & Families for BCORL1 Gene

Gene Families for BCORL1 Gene

Protein Domains for BCORL1 Gene

Suggested Antigen Peptide Sequences for BCORL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5H9F3

UniProtKB/Swiss-Prot:

BCORL_HUMAN :
  • Belongs to the BCOR family.
  • Contains 3 ANK repeats.
Family:
  • Belongs to the BCOR family.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with BCORL1: view

Function for BCORL1 Gene

Molecular function for BCORL1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
genes like me logo Genes that share phenotypes with BCORL1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCORL1 Gene

Localization for BCORL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCORL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCORL1 Gene COMPARTMENTS Subcellular localization image for BCORL1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for BCORL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BCORL1: view

Pathways & Interactions for BCORL1 Gene

SuperPathways for BCORL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCORL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with BCORL1: view

No data available for Pathways by source and SIGNOR curated interactions for BCORL1 Gene

Drugs & Compounds for BCORL1 Gene

No Compound Related Data Available

Transcripts for BCORL1 Gene

Unigene Clusters for BCORL1 Gene

BCL6 corepressor-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCORL1 Gene

No ASD Table

Relevant External Links for BCORL1 Gene

GeneLoc Exon Structure for
BCORL1
ECgene alternative splicing isoforms for
BCORL1

Expression for BCORL1 Gene

mRNA expression in normal human tissues for BCORL1 Gene

Protein differential expression in normal tissues from HIPED for BCORL1 Gene

This gene is overexpressed in Bone (41.5), Platelet (12.2), Fetal heart (9.0), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BCORL1 Gene



SOURCE GeneReport for Unigene cluster for BCORL1 Gene Hs.496748

mRNA Expression by UniProt/SwissProt for BCORL1 Gene

Q5H9F3-BCORL_HUMAN
Tissue specificity: Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.
genes like me logo Genes that share expression patterns with BCORL1: view

Protein tissue co-expression partners for BCORL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCORL1 Gene

Orthologs for BCORL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BCORL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCORL1 35
  • 91.09 (n)
  • 89.1 (a)
cow
(Bos Taurus)
Mammalia BCORL1 36
  • 89 (a)
OneToOne
BCORL1 35
  • 88.65 (n)
  • 91.97 (a)
dog
(Canis familiaris)
Mammalia BCORL1 35
  • 90.61 (n)
  • 92.97 (a)
BCORL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcorl1 16
Bcorl1 35
  • 86.79 (n)
  • 88.65 (a)
Bcorl1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCORL1 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCORL1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcorl1 35
  • 86.82 (n)
  • 89.28 (a)
chicken
(Gallus gallus)
Aves BCORL1 36
  • 55 (a)
OneToOne
BCORL1 35
  • 66.82 (n)
  • 61.43 (a)
lizard
(Anolis carolinensis)
Reptilia BCORL1 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12934 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bcorl1 35
  • 55.83 (n)
  • 48.92 (a)
zebrafish
(Danio rerio)
Actinopterygii CU459160.2 36
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14073 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOS4 36
  • 11 (a)
OneToMany
Species with no ortholog for BCORL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCORL1 Gene

ENSEMBL:
Gene Tree for BCORL1 (if available)
TreeFam:
Gene Tree for BCORL1 (if available)

Paralogs for BCORL1 Gene

Paralogs for BCORL1 Gene

(5) SIMAP similar genes for BCORL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with BCORL1: view

Variants for BCORL1 Gene

Sequence variations from dbSNP and Humsavar for BCORL1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5932715 - 130,013,397(+) CTCCC(A/G)GTTCG reference, missense
VAR_037468 A breast cancer sample
rs4830173 - 130,013,103(+) AGGGC(C/T)TCTTG reference, missense
VAR_070559 -
rs762949 -- 130,009,043(+) GTCCA(A/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCORL1 Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV Gain 19592680
nsv7090 CNV Loss 18451855

Variation tolerance for BCORL1 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCORL1 Gene

HapMap Linkage Disequilibrium report
BCORL1
Human Gene Mutation Database (HGMD)
BCORL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCORL1 Gene

Disorders for BCORL1 Gene

Relevant External Links for BCORL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCORL1

No disorders were found for BCORL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCORL1 Gene

Publications for BCORL1 Gene

  1. Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. (PMID: 23523425) Junco S.E. … Kim C.A. (Structure 2013) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. Mutational analysis of BCORL1 in the leukemic transformation of chronic myeloproliferative neoplasms. (PMID: 23793880) Rotunno G. … Vannucchi A.M. (Ann. Hematol. 2014) 3
  5. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3

Products for BCORL1 Gene

Sources for BCORL1 Gene

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