BCORL1 Gene
protein-coding GIFtS: 46
GCID: GC0XP129115
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BCL6 corepressor-like 1(Previous names: chromosome X open reading frame 10, BCL6 co-repressor-like...)
(Previous symbol: CXorf10)
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Aliases
for BCORL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BCL6 Corepressor-Like 11 2 | | BCoR-Like Protein 12 3 | | CXorf101 2 | | FLJ113621 | | BCL6 Co-Repressor-Like 11 2 | | Chromosome X Open Reading Frame 101 | | BCoR-L12 3 | | BCL-6 Corepressor-Like Protein 12 |
Export aliases for BCORL1 gene to outside databasesPrevious GC identifers: GC0XP128842 GC0XP128944 GC0XP118537 |
Summaries
for BCORL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BCORL1:
The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions byDNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to represstranscription. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,May 2010)
UniProtKB/Swiss-Prot: BCORL_HUMAN, Q5H9F3Function: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions bysequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histonedeacetylase activities which can associate with this corepressor
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Genomic Views
for BCORL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BCORL1 gene promoter:
POU2F1 POU2F1a GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BCORL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCORL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq25-q26.1 Ensembl cytogenetic band: Xq26.1 HGNC cytogenetic band: Xq25-q26.1BCORL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP129115: view genomic region
(about GC identifiers)
Start:
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129,115,083 bp from pter |
End:
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129,192,058 bp from pter |
Size:
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76,976 bases |
Orientation:
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plus strand |
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Proteins
for BCORL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BCORL_HUMAN, Q5H9F3 (See
protein sequence)Recommended Name: BCL-6 corepressor-like protein 1 Size: 1711 amino acids; 182526 Da
Subunit: Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7
Subcellular location: Nucleus
Sequence caution: Sequence=BAC85922.1; Type=Erroneous initiation;
Secondary accessions: B5MDQ8 Q5H9F2 Q5H9F4 Q6ZVE0 Q8TEN3 Q9Y528Alternative splicing: 3 isoforms: Q5H9F3-1 Q5H9F3-2 Q5H9F3-3 (Contains a phosphoserine at position 1476)Explore the universe of human proteins at neXtProt for BCORL1: NX_Q5H9F3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5H9F3
BCORL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068765.3
ENSEMBL proteins: ENSP00000218147 ENSP00000399483 ENSP00000416520 ENSP00000307541 ENSP00000352253 ENSP00000437775
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
BCORL1 for ontologies About GeneDecksing
BCORL1 Antibody Products:
Assay Products for BCORL1: |
Protein
Domains /
Families
for BCORL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BCORL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5H9F3ProtoNet protein and cluster: Q5H9F3 UniProtKB/Swiss-Prot: BCORL_HUMAN, Q5H9F3Similarity: Belongs to the BCOR familySimilarity: Contains 3 ANK repeats |
Function
for BCORL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BCORL_HUMAN, Q5H9F3Function: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions bysequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histonedeacetylase activities which can associate with this corepressor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCORL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCORL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCORL1 |
1 GenomeRNAi human phenotype for BCORL1:
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Pathways & Interactions
for BCORL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BCORL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for BCORL1 (Q5H9F33 ENSP000002181474) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0016568 | chromatin modification |
IEA | -- |
BCORL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for BCORL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BCORL1
Search CenterWatch for drugs/clinical trials and news about BCORL1 / BCORL
|
Transcripts
for BCORL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BCORL1 gene (2 alternative transcripts): NM_021946.4 NM_001184772.1 Unigene Cluster for BCORL1: BCL6 corepressor-like 1 Hs.496748 [show with all ESTs]Unigene Representative Sequence: NM_0219467 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000488135 ENST00000218147 ENST00000456822 ENST00000441294 ENST00000303743
ENST00000359304(uc010nrd.1) ENST00000540052(uc022cdu.1 uc004evc.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCORL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCORL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BCORL1 (NM_021946) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCORL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCORL1 |
Additional cDNA sequence: AK021424.1 AK074089.1 AK124676.1 AL096777.1 BC044652.1 7 DOTS entries: DT.454704 DT.100747170 DT.121288669 DT.100704250 DT.100747169 DT.121288646 DT.97841754 24/90 AceView cDNA sequences (see all 90): BM683765 CD369739 AL096777 BQ011735 AK021424 AI917324 BM457842 BX107682 BM930296 BI031136 BQ719887 BU620363 CD671907 BM973587 AK124676 CR621400 CD630956 BF765194 BQ011054 AK074089 R53772 BQ707930 BQ007466 NM_021946
GeneLoc Exon Structure
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Expression
for BCORL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BCORL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See BCORL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCORL1
SOURCE GeneReport for Unigene cluster: Hs.496748
UniProtKB/Swiss-Prot: BCORL_HUMAN, Q5H9F3Tissue specificity: Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen
SABiosciences Custom PCR Arrays for BCORL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCORL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCORL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCORL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCORL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCORL1 |
Orthologs
for BCORL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BCORL1 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for BCORL1 (if available)
TreeFam Gene Tree for BCORL1 (if available) |
Paralogs
for BCORL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BCORL1 gene
- BCOR2
5 SIMAP similar genes for BCORL1 using alignment to 4 protein entries: BCORL_HUMAN (see all proteins):BCOR BCOR-RARA DKFZp761E1322 MTPN PPP1R12A
BCORL1 for paralogs About GeneDecksing
|
Genomic Variants
for BCORL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BCORL1 (129115083 - 129192058 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BCORL1: --
Human Gene Mutation Database (HGMD): BCORL1
Locus Specific Mutation Databases (LSDB): BCORL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCORL1 |
|
Disorders
/ Diseases
for BCORL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BCORL1 for disorders About GeneDecksing
OMIM gene information: 300688
OMIM disorders: --
4  diseases for BCORL1: About MalaCardsmale breast cancer breast cancer leukemia prostatitis
Export disorders for BCORL1 gene to outside databases
|
Publications
for BCORL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BCORL1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with BCORL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. (PubMed id 17379597)1, 2 Pagan J.K.... Khanna K.K. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia. (PubMed id 21989985)1 Li M....Malek S.N. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
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External Searches for BCORL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BCORL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BCORL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BCORL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BCORL1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BCORL1 gene:
Search GeneIP for patents involving BCORL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BCORL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BCORL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCORL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCORL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BCORL1 | | OriGene 3'-UTR Clone for BCORL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCORL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCORL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCORL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCORL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCORL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCORL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCORL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCORL1 |
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 | | | BCORL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCORL1 |
|  |  |  | | | | ThermoFisher Antibody for BCORL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCORL1 |
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