Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCOR Gene

protein-coding   GIFtS: 61
GCID: GC0XM039909

BCL6 Corepressor

(Previous name: BCL6 co-repressor)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL6 Corepressor1 2     BCL6 Co-Repressor1
ANOP22 5     BCL-6 Corepressor2
MAA22 5     BCL-6 Interacting Corepressor2
MCOPS22 5     BCoR3
KIAA15753 5     

External Ids:    HGNC: 208931   Entrez Gene: 548802   Ensembl: ENSG000001833377   OMIM: 3004855   UniProtKB: Q6W2J93   

Export aliases for BCOR gene to outside databases

Previous GC identifers: GC0XM038755 GC0XM038941 GC0XM039666 GC0XM039794 GC0XM037648


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCOR Gene:
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger
transcription repressor that is required for germinal center formation and may influence apoptosis. This protein
selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II
histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link
between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for
this gene. A pseudogene of this gene is found on chromosome Y.(provided by RefSeq, Jun 2010)

GeneCards Summary for BCOR Gene: 
BCOR (BCL6 corepressor) is a protein-coding gene. Diseases associated with BCOR include lenz microphthalmia syndrome, and oculofaciocardiodental syndrome. GO annotations related to this gene include transcription corepressor activity and transcription factor binding. An important paralog of this gene is BARD1.

UniProtKB/Swiss-Prot: BCOR_HUMAN, Q6W2J9
Function: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions
by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in
part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of
TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative
regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on
histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2)

Gene Wiki entry for BCOR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCOR gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   E2F-2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCOR promoter sequence
   Search SABiosciences Chromatin IP Primers for BCOR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11.4

BCOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCOR gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM039909:  view genomic region     (about GC identifiers)

Start:
39,909,068 bp from pter      End:
40,036,582 bp from pter
Size:
127,515 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BCOR_HUMAN, Q6W2J9 (See protein sequence)
Recommended Name: BCL-6 corepressor  
Size: 1755 amino acids; 192189 Da
Subunit: Isoform 1 may interact with MLLT3/AF9 (By similarity). Interacts with BCL6; the interaction is direct.
Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B.
Component of an approximative 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1,
RNF2/RING2, KDM2B and SKP1
Subcellular location: Nucleus
Sequence caution: Sequence=AAH63536.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Presence of
complementary strand sequence in the clone; Sequence=BAA91061.1; Type=Miscellaneous discrepancy; Note=Intron
retention; Sequence=BAB13401.2; Type=Erroneous initiation; Sequence=BAB85037.1; Type=Frameshift; Positions=1353;
2 PDB 3D structures from and Proteopedia for BCOR:
3BIM (3D)        4HPL (3D)    
Secondary accessions: D3DWB3 D3DWB4 Q29RF6 Q6P4B6 Q7Z2K7 Q8TEB4 Q96DB3 Q9H232 Q9H233 Q9HCJ7
Q9NXF2
Alternative splicing: 4 isoforms:  Q6W2J9-1   Q6W2J9-2   Q6W2J9-3   Q6W2J9-4   

Explore the universe of human proteins at neXtProt for BCOR: NX_Q6W2J9

Explore proteomics data for BCOR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6W2J9

  • BCOR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCOR Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001116855.1  NP_001116856.1  NP_001116857.1  NP_060215.4  

    ENSEMBL proteins: 
     ENSP00000408006   ENSP00000367724   ENSP00000380512   ENSP00000367716   ENSP00000367705  
     ENSP00000387552   ENSP00000403823   ENSP00000384485   ENSP00000390273   ENSP00000345923  

    Human Recombinant Protein Products for BCOR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCOR
    OriGene Protein Over-expression Lysate for BCOR
    OriGene MassSpec for BCOR 
    OriGene Custom Protein Services for BCOR
    GenScript Custom Purified and Recombinant Proteins Services for BCOR
    Novus Biologicals BCOR Proteins
    Novus Biologicals BCOR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCOR 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10898795
    GO:0031519colocalizes with PcG protein complex IDA16943429

    BCOR for ontologies           About GeneDecksing



    BCOR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BCOR
    GenScript Custom Superior Antibodies Services for BCOR
    Novus Biologicals BCOR Antibodies
    Abcam antibodies for BCOR
    Cloud-Clone Corp. Antibodies for BCOR 
    ThermoFisher Antibodies for BCOR
    LSBio Antibodies in human, mouse, rat for BCOR 

    Assay Products for BCOR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCOR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCOR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BCOR 
    Cloud-Clone Corp. CLIAs for BCOR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q6W2J9

    ProtoNet protein and cluster: Q6W2J9

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: BCOR_HUMAN, Q6W2J9
    Similarity: Belongs to the BCOR family
    Similarity: Contains 3 ANK repeats


    BCOR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCOR_HUMAN, Q6W2J9
    Function: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions
    by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in
    part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of
    TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative
    regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on
    histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IMP15878880
    GO:0004842contributes to ubiquitin-protein ligase activity IDA16943429
    GO:0005515protein binding IPI10898795
    GO:0008134transcription factor binding IPI10898795
    GO:0031072heat shock protein binding IDA16943429
         
    BCOR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCOR:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Bcor):
     cardiovascular system  craniofacial  embryogenesis  mortality/aging  nervous system 

    BCOR for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCOR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCOR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCOR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCOR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCOR
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate BCOR (see all 37):
    hsa-miR-3607-3p hsa-miR-485-3p hsa-miR-3653 hsa-miR-30d hsa-miR-570 hsa-miR-30a hsa-miR-3658 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidBCOR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BCOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCOR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCOR
    Sirion Biotech Customized adenovirus for overexpression of BCOR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BCOR (see all 22)
    OriGene ORF clones in mouse, rat for BCOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): BCOR (NM_001123384)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCOR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCOR
    Search LifeMap BioReagents cell lines for BCOR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCOR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCOR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by HDAC Class II
    Signaling events mediated by HDAC Class II


    1 BioSystems Pathway for BCOR
        Signaling events mediated by HDAC Class II


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for BCOR (Q6W2J91, 2, 3 ENSP000003677054) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDM2BQ8NHM51, 3, ENSP000003662714EBI-950027,EBI-3955564 I2D: score=3 STRING: ENSP00000366271
    ENSG00000235107Q065873, ENSP000003964394I2D: score=1 STRING: ENSP00000396439
    ENSG00000206287Q065873I2D: score=1 
    ENSG00000226788Q065873I2D: score=1 
    ENSG00000228520Q065873I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP19578371
    GO:0000415negative regulation of histone H3-K36 methylation IMP19578371
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007507heart development IMP17517692
    GO:0030502negative regulation of bone mineralization IMP19578371

    BCOR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCOR

    Search CenterWatch for drugs/clinical trials and news about BCOR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCOR gene (6 alternative transcripts): 
    NM_001123383.1  NM_001123384.1  NM_001123385.1  NM_017745.5  NM_001130139.1  NM_020926.2  

    Unigene Cluster for BCOR:

    BCL6 corepressor
    Hs.659681  [show with all ESTs]
    Unigene Representative Sequence: JN813375
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413905 ENST00000378463 ENST00000397354(uc010nhb.3 uc004dem.4)
    ENST00000378455(uc004deo.4) ENST00000378444(uc004den.4) ENST00000442018
    ENST00000427012 ENST00000406200 ENST00000490976(uc004deq.4) ENST00000412952
    ENST00000342274(uc004dep.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCOR
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate BCOR (see all 37):
    hsa-miR-3607-3p hsa-miR-485-3p hsa-miR-3653 hsa-miR-30d hsa-miR-570 hsa-miR-30a hsa-miR-3658 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidBCOR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BCOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCOR
    Clone
    Products:
         
    OriGene clones in human, mouse for BCOR (see all 22)
    OriGene ORF clones in mouse, rat for BCOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): BCOR (NM_001123384)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCOR
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BCOR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCOR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCOR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCOR

    Additional mRNA sequence: 

    AF317391.1 AK000292.1 AK056538.1 AK074286.1 AK095360.1 AK225581.1 AY316592.1 BC009675.2 
    BC063536.1 BC114220.1 BC128387.1 HM597846.1 JN813375.1 

    15 DOTS entries:

    DT.92418971  DT.411076  DT.97841302  DT.100780299  DT.205488  DT.97814660  DT.97841303  DT.121311318 
    DT.40267574  DT.95155854  DT.121311362  DT.86845733  DT.75164970  DT.91783369  DT.95370753 

    24/115 AceView cDNA sequences (see all 115):

    AW071020 AK074286 AB046795 AK095360 AL044059 AW969328 BF793183 BG390446 
    BQ879529 BC009675 BU181901 AA469036 BM466278 AL044058 AI635681 BP355895 
    AW502817 AA535437 AK056538 BE792825 AI005244 AJ706599 BG117044 AI674453 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BCOR (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                            -                                                                             -         
    SP2:                                            -                       -                                                     -         
    SP3:                                            -     -                 -                                                     -         
    SP4:                                                                                                                                    
    SP5:        -                                                                                                                           


    ECgene alternative splicing isoforms for BCOR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCOR expression in normal human tissues (normalized intensities)      BCOR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTAGAGT
    BCOR Expression
    About this image


    BCOR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             cmps   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord

     -- (Extraembryonic Tissues)
             extraembryonic component   

    See BCOR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCOR

    SOURCE GeneReport for Unigene cluster: Hs.659681

    UniProtKB/Swiss-Prot: BCOR_HUMAN, Q6W2J9
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including BCOR: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BCOR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCOR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCOR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCOR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BCOR gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcor1 , 5 BCL6 interacting corepressor1, 5 87.94(n)1
    89.1(a)1
      X (6.83 cM)5
    714581  NM_029510.31  NP_083786.21 
     120367405 
    chicken
    (Gallus gallus)
    Aves BCOR1 BCL6 corepressor 72.57(n)
    71.51(a)
      418574  XM_003640508.1  XP_003640556.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCOR6
    BCL6 corepressor
    70(a)
    1 ↔ 1
    3(133398858-133459421)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.161632 Danio rerio BCL-6 corepressor mRNA, complete cds 73.89(n)    AY316593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG140736
    --
    8(a)
    1 → many
    3L(18795365-18813775)


    ENSEMBL Gene Tree for BCOR (if available)
    TreeFam Gene Tree for BCOR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCOR gene
    BARD12  ANKRD112  TONSL2  ANKRD322  ANKRD122  ANKRD312  BCORL12  
    7 SIMAP similar genes for BCOR using alignment to 8 protein entries:     BCOR_HUMAN (see all proteins):
    BCOR-RARA    BCORP1    BCORL1    IkBa    PPP1R12A    DKFZp761E1322
    MTPN

    BCOR for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BCOR
    PGOHUM00000233784


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1635 SNPs in BCOR are shown (see all 1635)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0209214
    Microphthalmia, syndromic, 2 (MCOPS2)4--see VAR_0209212 P L mis40--------
    rs1817917531,2
    --37694177(+) GCCGCC/TGAGCT 1 -- int10--------
    rs1847210771,2
    --39874957(+) CCAGAA/GGAGCC 2 -- int10--------
    rs78799041,2
    C,F,H--39875141(+) GTCGGC/AGAGCG 2 -- int113Minor allele frequency- A:0.24NS EA NA CSA 1647
    rs1810314401,2
    --39876071(+) ACAACC/TGATGC 2 -- int10--------
    rs1864288941,2
    --39876286(+) CTATTC/TTTTAT 2 -- int10--------
    rs1913255611,2
    --39876370(+) AGGCCA/TCTGGT 2 -- int10--------
    rs1493560051,2
    --39876447(+) GGAAGG/TCTGAA 2 -- int10--------
    rs1813303731,2
    --39876995(+) GGGGTA/GCTGTA 2 -- int10--------
    rs128411081,2
    C,F,H--39877066(+) GGCCAG/ATAAAT 2 -- int1 tfbs38Minor allele frequency- A:0.05NS EA NA 1086

    HapMap Linkage Disequilibrium report for BCOR (39909068 - 40036582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BCOR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672664CNV Deletion23128226
    esv33829CNV Loss17666407
    esv21995CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): BCOR

    Locus Specific Mutation Databases (LSDB): BCOR
    1 SABiosciences Cancer Mutation PCR Assay for BCOR:
    Cosmic IdAA Change
    26337p.T322T
    SeqTarget long-range PCR primers for resequencing BCOR
    DNA2.0 Custom Variant and Variant Library Synthesis for BCOR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300485   
    OMIM disorders: 300166  
    UniProtKB/Swiss-Prot: BCOR_HUMAN, Q6W2J9
  • Microphthalmia, syndromic, 2 (MCOPS2) [MIM:300166]: A very rare multiple congenital anomaly syndrome
    characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities
    (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or
    submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral
    valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth,
    or variable root length). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye
    to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs
    in association with syndromes that include non-ocular abnormalities. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 19 diseases for BCOR:    About MalaCards
    lenz microphthalmia syndrome    oculofaciocardiodental syndrome    bcor-related lenz microphthalmia syndrome    radioulnar synostosis
    dextrocardia    synostosis    microphthalmia    ventricular septal defect
    acute promyelocytic leukemia    coloboma    microcephaly    cataract
    cleft palate    glaucoma    mental retardation    acute myeloid leukemia
    myeloid leukemia    sarcoma    leukemia

    2 diseases from the University of Copenhagen DISEASES database for BCOR:
    Microphthalmia     Coloboma

    BCOR for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for BCOR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ofcd syndrome 98.3 10 19367324 (3), 15770227 (3), 16943429 (1)
    microphthalmia 83.1 10 15770227 (4), 19367324 (3), 17033686 (1)
    mental retardation 55.7 1 19367324 (1)

    GeneTests: BCOR
    GeneReviews: BCOR

    Export disorders for BCOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCOR gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with BCOR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BCoR, a novel corepressor involved in BCL-6 repression. (PubMed id 10898795)1, 2, 3, 9 Huynh K.D.... Bardwell V.J. (2000)
    2. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (2006)
    3. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. (PubMed id 19578371)1, 2 Fan Z....Wang C.-Y. (2009)
    4. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. (PubMed id 18280243)1, 2 Ghetu A.F....Prive G.G. (2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. (PubMed id 15004558)1, 2 Ng D....Biesecker L.G. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    9. BCOR analysis in patients with OFCD and Lenz micropht halmia syndromes, mental retardation with ocular anomalies, and cardiac lateral ity defects. (PubMed id 19367324)1, 9 Hilton E....Black G. (2009)
    10. Novel mutations in BCOR in three patients with oculo-facio-cardio-dental syndrome, but none in Lenz microphthalmia syndrome. (PubMed id 15770227)1, 9 Horn D....Kutsche K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54880 HGNC: 20893 AceView: BCOR Ensembl:ENSG00000183337 euGenes: HUgn54880
    ECgene: BCOR H-InvDB: BCOR

    (According to HUGE)
    About This Section
    HUGE: KIAA1575

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCOR Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/BCOR

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCOR gene:
    Search GeneIP for patents involving BCOR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BCOR  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for BCOR  
     OriGene MassSpec something-or-other for BCOR   OriGene clones in human, mouse for BCOR  
     OriGene qSTAR qPCR primer pairs in human, mouse for BCOR   OriGene Purified Protein for BCOR  
     OriGene ORF clones in mouse, rat for BCOR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCOR   OriGene Custom Protein Services for BCOR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCOR
     QIAGEN SeqTarget long-range PCR primers for resequencing BCOR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCOR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCOR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCOR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCOR
     GenScript Custom Purified and Recombinant Proteins Services for BCOR GenScript cDNA clones with any tag delivered in your preferred vector for BCOR
     GenScript Custom Assay Services for BCOR GenScript Custom Superior Antibodies Services for BCOR
     GenScript Custom overexpressing Cell Line Services for BCOR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BCOR promoter
     Search Chromatin IP Primers for BCOR
     RT2 qPCR Primer Assay in human, mouse, rat BCOR
     GNC Network for BCOR
     SABiosciences PCR Arrays including human, mouse, rat BCOR
     Search Tocris compounds for BCOR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BCOR antibodies
     BCOR proteins
     BCOR lysates
     Antibodies for BCOR
     See all of Abcam's Antibodies, Kits and Proteins for BCOR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for BCOR
     Antibodies for BCOR
     ELISAs for BCOR
     CLIAs for BCOR
     Search LifeMap BioReagents cell lines for BCOR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCOR
     SwitchGear 3'UTR luciferase reporter plasmids for BCOR
     SwitchGear Promoter luciferase reporter plasmids for BCOR
     ThermoFisher Antibodies for BCOR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCOR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BCOR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCOR
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of BCOR
     LSBio Antibodies in human, mouse, rat for BCOR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCOR gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4