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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCO2 Gene

protein-coding   GIFtS: 53
GCID: GC11P112046

beta-carotene oxygenase 2

(Previous name: beta-carotene dioxygenase 2 )
(Previous symbol: BCDO2)
 Explore 5 diseases affiliated with
BCO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BCO2    

Aliases
for BCO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Beta-Carotene Oxygenase 21 2     Beta,Beta-Carotene 9',10'-Oxygenase2
BCDO21 2 3 5     Beta-Carotene 9',10' Oxygenase2
Beta-Carotene Dioxygenase 21 2 3     B-Diox-II1
B-DIOX-II1 2     EC 1.13.11.713
FLJ344641     EC 1.14.998
B,B-Carotene-9',10'-Dioxygenase1     EC 1.14.99.368
Beta,Beta-Carotene 9',10'-Dioxygenase Variant 12     

External Ids:    HGNC: 185031   Entrez Gene: 838752   Ensembl: ENSG000001975807   OMIM: 6117405   UniProtKB: Q9BYV73   

Export aliases for BCO2 gene to outside databases

Previous GC identifers: GC11P111552 GC11P107970


Summaries
for BCO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BCO2:
This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: BCDO2_HUMAN, Q9BYV7
Function: Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of
beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals
formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological
effects




Genomic Views
for BCO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCO2 gene promoter:
         TBP   AP-1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BCO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

BCO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCO2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P112046:  view genomic region     (about GC identifiers)

Start:
 112,046,190 bp from pter      End:
 112,095,422 bp from pter
Size:
 49,233 bases      Orientation:
 plus strand

Proteins
for BCO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BCDO2_HUMAN, Q9BYV7 (See protein sequence)
Recommended Name: Beta,beta-carotene 9',10'-oxygenase  
Size: 579 amino acids; 65674 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subcellular location: Mitochondrion
Sequence caution: Sequence=CAC27994.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B0YIX5 Q96JC8 Q96JY5
Alternative splicing: 3 isoforms:  Q9BYV7-1   Q9BYV7-2   Q9BYV7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCO2: NX_Q9BYV7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYV7

    • 4/15 DME Specific Peptides for BCO2 (Q9BYV7) (see all 15)
     YNHWFDG  IDLCCQD  TSKIRGK  PSYYHSFG 

    BCO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001032367.2  NP_001243326.1  NP_001243327.1  NP_001243329.1  NP_114144.4  

    ENSEMBL proteins: 
     ENSP00000350314   ENSP00000434488   ENSP00000354338   ENSP00000435869   ENSP00000436956  
     ENSP00000414843   ENSP00000436615   ENSP00000431802   ENSP00000437053   ENSP00000432045  
     ENSP00000431882   ENSP00000376752  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC11278918
    GO:0005739mitochondrion TAS--


    BCO2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for BCO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BCO2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004294 Carotenoid_Oase

    Graphical View of Domain Structure for InterPro Entry Q9BYV7

    ProtoNet protein and cluster: Q9BYV7

    UniProtKB/Swiss-Prot: BCDO2_HUMAN, Q9BYV7
    Similarity: Belongs to the carotenoid oxygenase family


    Function
    for BCO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BCDO2_HUMAN, Q9BYV7
    Function: Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of
    beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals
    formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological
    effects
    Catalytic activity: All-trans-beta-carotene + O(2) = all-trans-10'-apo-beta-carotenal + beta-ionone

    Enzyme Numbers (IUBMB): EC 1.14.992 EC 1.13.11.711 EC 1.14.99.362

    miRNA
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    hsa-miR-498 hsa-miR-630 hsa-miR-578 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: BCO2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for BCO2

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA--
    GO:0046872metal ion binding IEA--


    BCO2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BCO2:
     Decreased viability of wild-ty 

    Animal Models:
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bco2):
     adipose tissue  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  reproductive system 

    BCO2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BCO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Retinol metabolism
    		Retinol metabolism1.00
    		Retinol metabolism0.95
    2Vitamin A and carotenoid metabolism
    		Vitamin A and carotenoid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for BCO2
        Retinol metabolism


    1 GeneGo (Thomson Reuters) Pathway for BCO2
        Retinol metabolism

    1 BioSystems Pathway for BCO2 
        Vitamin A and carotenoid metabolism



    BCO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BCO2

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016116carotenoid metabolic process ISS--
    GO:0016119carotene metabolic process IDA11278918
    GO:0016121carotene catabolic process IDA--
    GO:0042573retinoic acid metabolic process NAS11278918
    GO:0042574retinal metabolic process NAS11278918


    BCO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BCO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCO2

    2 HMDB Compounds for BCO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    Lycopene(6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-Octamethyl-2,6,8,10,12,14,16,18,20,22,24,26,30-dotriacontatridecaene (see all 7)502-65-8--
    Search CenterWatch for drugs/clinical trials and news about BCO2 / BCDO2 

    Transcripts
    for BCO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BCO2 gene (5 alternative transcripts): 
    NM_001037290.2  NM_001256397.1  NM_001256398.1  NM_001256400.1  NM_031938.5  

    Unigene Cluster for BCO2:

    Beta-carotene oxygenase 2
    Hs.728325  [show with all ESTs]
    Unigene Representative Sequence: NM_031938
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000357685(uc001pnf.3 uc001png.3 uc001pnh.3 uc010rwt.2 uc009yyn.3)
    ENST00000460924 ENST00000461480 ENST00000534550 ENST00000361053 ENST00000531003
    ENST00000494860(uc001pne.1) ENST00000527939 ENST00000534122 ENST00000438022
    ENST00000526088 ENST00000532593 ENST00000531169(uc001pni.3) ENST00000530677
    ENST00000527198 ENST00000525175 ENST00000532716 ENST00000532673

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BCO2:
    hsa-miR-498 hsa-miR-630 hsa-miR-578 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: BCO2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCO2

    Additional cDNA sequence: 

    AB096252.1 AF276432.1 AJ290393.1 AK027801.1 AK297853.1 AK315300.1 BC041656.1 

    9 DOTS entries:

    DT.99976659  DT.100774403  DT.95087586  DT.95261081  DT.97796521  DT.100774405  DT.120733726  DT.101961111 
    DT.40230284 

    24/1371 AceView cDNA sequences (see all 1371):

    BX354210 AJ709307 BX476384 CR617068 BQ962548 BM758814 AA298733 AA302990 
    CB162567 AL561498 BC041656 AK091783 CD245358 BM476425 BQ938179 AB096252 
    T24605 BF698281 AA421012 BU159491 BQ222328 BE877634 BM312481 CD105572 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for BCO2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13
    SP1:                    -     -           -           -                                               -                 -               
    SP2:                                      -           -                                               -                 -               
    SP3:                                      -           -                                               -           -     -               
    SP4:                    -     -           -           -     -     -                                   -                 -               
    SP5:                    -     -     -     -                                                           -                                 


    ECgene alternative splicing isoforms for BCO2

    Expression
    for BCO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCCCAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BCO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Embryoid bodies (Two-step protocol fo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BCO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCO2

    SOURCE GeneReport for Unigene cluster: Hs.728325

    UniProtKB/Swiss-Prot: BCDO2_HUMAN, Q9BYV7
    Tissue specificity: Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver,
    testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level)

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    In Situ
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    Orthologs
    for BCO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BCO2 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BCO21 beta-carotene oxygenase 2 70.5(n)
    68.39(a)    		   419792  XM_417929.3  XP_417929.2 
    lizard
    (Anolis carolinensis)    		 Reptilia BCO26
    		 --
    		 40(a)
    		 1 ↔ 1
    		 GL343973.1(16623-36304)
    zebrafish
    (Danio rerio)    		 Actinopterygii bcdo22 beta-carotene 15, 15-dioxygenase 2 73.06(n)   84041  AJ290391.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ninaB6
    		 neither inactivation nor afterpotential B
    		 29(a)
    		 1 → many
    		 3R(9526308-9528844)
    worm
    (Caenorhabditis elegans)    		 Secernentea bcmo-26
    bcmo-16
    		 Beta-Carotene 15,15'-MonoOxygenase family member (...
    Beta-Carotene 15,15'-MonoOxygenase family member (...
    		 31(a)
    31(a)
    		 many ↔ many
    many ↔ many
    		 II(3908491-3910839)
    II(12830638-12832651)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CCD81 carotenoid cleavage dioxygenase 8 45.02(n)
    34.43(a)    		   829417  NM_119434.3  NP_195007.2 
    rice
    (Oryza sativa)    		 Liliopsida Os01g07464001 hypothetical protein 42.17(n)
    34.3(a)    		   4326177  NM_001050764.2  NP_001044229.2 


    ENSEMBL Gene Tree for BCO2 (if available)
    TreeFam Gene Tree for BCO2 (if available) 

    Paralogs
    for BCO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCO2 gene
    BCMO12  RPE652  
    3 SIMAP similar genes for BCO2 using alignment to 8 protein entries:     BCDO2_HUMAN (see all proteins):
    BCDO2    BCMO1    RPE65

    BCO2 for paralogs           About GeneDecksing



    Genomic Variants
    for BCO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/798 NCBI SNPs in BCO2 are shown (see all 798)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs112141091,2
    		C,--112044226(+) TGGTGC/TGATCT 2 -- us2k13Minor allele frequency- T:0.07NS NA 42
    rs1876238861,2
    		--112044227(+) GGTGCA/GATCTT 2 -- us2k10--------
    rs1924933831,2
    		--112044325(+) CACCCA/GGCTAA 2 -- us2k10--------
    rs455704411,2
    		F--112044339(+) TTGTAT/GTTTTA 2 -- us2k11Minor allele frequency- G:0.26NS 38
    rs124204761,2
    		C,F,H,--112044398(+) acctcA/Cggtga 2 -- us2k1 tfbs34Minor allele frequency- C:0.20NS NA 44
    rs1407513291,2
    		--112044514(+) TAATAC/TGACAT 2 -- us2k10--------
    rs801043151,2
    		--112044537(+) TCGACC/TTACCA 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs454916971,2
    		F--112044584(+) TAATAT/AGAAAA 2 -- us2k11Minor allele frequency- A:0.08NS 38
    rs133288431,2
    		C,F,--112044687(+) TGCAGG/CTTCAG 2 -- us2k111Minor allele frequency- C:0.47NS NA WA CSA EA 410
    rs25539341,2
    		C,F,H,--112044693(-) AATTTT/ACTGAA 2 -- us2k114Minor allele frequency- A:0.04NS EA NA WA CSA 543

    HapMap Linkage Disequilibrium report for BCO2 (112046190 - 112095422 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for BCO2
         1 CNV: 86043
         1 Indel: 75825

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCO2
    DNA2.0 Custom Variant and Variant Library Synthesis for BCO2

    Disorders / Diseases
    for BCO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BCO2 for disorders           About GeneDecksing

    OMIM gene information: 611740    OMIM disorders: --

    5 diseases for BCO2:    About MalaCards
    leber congenital amaurosis    intrahepatic cholangiocarcinoma    cholangiocarcinoma    retinitis
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: BCO2 (4 documents)

    Export disorders for BCO2 gene to outside databases

    Publications
    for BCO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCO2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with BCO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues. (PubMed id 15983114)1, 2, 3 Lindqvist A.... Andersson S. (2005)
    2. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. (PubMed id 11278918)1, 2, 3 Kiefer C.... von Lintig J. (2001)
    3. A mitochondrial enzyme degrades carotenoids and prote cts against oxidative stress. (PubMed id 21106934)1, 2 Amengual J....von Lintig J. (2011)
    4. Towards a better understanding of carotenoid metaboli sm in animals. (PubMed id 15949678)1, 3 von Lintig J....Vogt K. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    7. Production of I^-apo-10'-carotenal from I^-carotene by human I^-carotene-9',10'-oxygenase expressed in E. coli. (PubMed id 21302131)1 Kim Y.S....Oh D.K. (2011)
    8. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    9. Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels. (PubMed id 20150558)1 He M....Qi L. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    External Searches for BCO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing BCO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83875 HGNC: 18503 AceView: SDHDandTEX12 Ensembl:ENSG00000197580 euGenes: HUgn83875
    ECgene: BCO2 H-InvDB: BCO2

    Other Databases showing BCO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BCO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCO2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BCO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BCO2 gene:
    Search GeneIP for patents involving BCO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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