Aliases for BCO1 Gene
External Ids for BCO1 Gene
Previous HGNC Symbols for BCO1 Gene
Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCO1 Gene
BCO1 (Beta-Carotene Oxygenase 1) is a Protein Coding gene. Diseases associated with BCO1 include Hypercarotenemia And Vitamin A Deficiency, Autosomal Dominant and Hereditary Hypercarotenemia And Vitamin A Deficiency. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. GO annotations related to this gene include monooxygenase activity and beta-carotene 15,15-monooxygenase activity. An important paralog of this gene is RPE65.
UniProtKB/Swiss-Prot for BCO1 Gene
Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.