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Aliases for BCLAF3 Gene

Aliases for BCLAF3 Gene

  • BCLAF1 And THRAP3 Family Member 3 2 3 5
  • CXorf23 3 4
  • Chromosome X Open Reading Frame 23 2
  • Uncharacterized Protein CXorf23 3

External Ids for BCLAF3 Gene

Previous HGNC Symbols for BCLAF3 Gene

  • CXorf23

Summaries for BCLAF3 Gene

GeneCards Summary for BCLAF3 Gene

BCLAF3 (BCLAF1 And THRAP3 Family Member 3) is a Protein Coding gene. An important paralog of this gene is THRAP3.

Additional gene information for BCLAF3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCLAF3 Gene

Genomics for BCLAF3 Gene

Regulatory Elements for BCLAF3 Gene

Enhancers for BCLAF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH020139 1 ENCODE 44.5 -150.8 -150765 4 HDGF PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF121 BCLAF3 EIF1AX EIF1AX-AS1
GH0XH019989 1.1 Ensembl ENCODE 38.3 +0.2 234 2 RB1 ZNF76 SIN3A RAD21 GLIS2 ELK1 ZNF143 RCOR1 SP3 ZBTB11 BCLAF3 MAP7D2 LOC729609
GH0XH020066 1.1 Ensembl ENCODE 27.7 -76.8 -76809 1 ZBTB40 RAD21 ZNF143 FOS ZNF654 CEBPB ZEB2 REST MAFF PRDM4 BCLAF3 MAP7D2 SH3KBP1 MIR23C
GH0XH019846 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +143.7 143698 2 ATF1 MAX EBF1 BATF FOSL1 ZNF664 ZNF316 ZBTB48 EED FOS BCLAF3 SH3KBP1 GC0XP019714
GH0XH019771 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +216.4 216365 7 HDGF PKNOX1 RB1 ZSCAN4 YBX1 EBF1 BATF RELA ZFHX2 EED SH3KBP1 BCLAF3 MAP7D2 RPS6KA3 GC0XP019714
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCLAF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCLAF3 Gene

Chromosome:
X
Start:
19,912,860 bp from pter
End:
19,990,934 bp from pter
Size:
78,075 bases
Orientation:
Minus strand

Genomic View for BCLAF3 Gene

Genes around BCLAF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCLAF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCLAF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCLAF3 Gene

Proteins for BCLAF3 Gene

  • Protein details for BCLAF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2AJT9-CX023_HUMAN
    Recommended name:
    Uncharacterized protein CXorf23
    Protein Accession:
    A2AJT9
    Secondary Accessions:
    • A1A4E8
    • Q5VSM7
    • Q5VSN1
    • Q6ZS60
    • Q8N1W7

    Protein attributes for BCLAF3 Gene

    Size:
    711 amino acids
    Molecular mass:
    83871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04399.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87094.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71712.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for BCLAF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCLAF3 Gene

Post-translational modifications for BCLAF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCLAF3 Gene

Domains & Families for BCLAF3 Gene

Gene Families for BCLAF3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BCLAF3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCLAF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCLAF3: view

No data available for UniProtKB/Swiss-Prot for BCLAF3 Gene

Function for BCLAF3 Gene

genes like me logo Genes that share phenotypes with BCLAF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCLAF3 Gene

Localization for BCLAF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCLAF3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCLAF3 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BCLAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with BCLAF3: view

Pathways & Interactions for BCLAF3 Gene

SuperPathways for BCLAF3 Gene

No Data Available

Interacting Proteins for BCLAF3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369009%0d%0a9606.ENSP00000354346%0d%0a
Selected Interacting proteins: ENSP00000369009 A2AJT9-CX023_HUMAN for BCLAF3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BCLAF3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BCLAF3 Gene

Drugs & Compounds for BCLAF3 Gene

No Compound Related Data Available

Transcripts for BCLAF3 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCLAF3 Gene

No ASD Table

Relevant External Links for BCLAF3 Gene

GeneLoc Exon Structure for
BCLAF3
ECgene alternative splicing isoforms for
BCLAF3

Expression for BCLAF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCLAF3 Gene:

BCLAF3

Evidence on tissue expression from TISSUES for BCLAF3 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCLAF3 Gene

Orthologs for BCLAF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCLAF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXorf23 34
  • 100 (a)
OneToOne
CXHXorf23 33
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia CXHXorf23 33
  • 87.27 (n)
CXorf23 34
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXHXorf23 33
  • 84.09 (n)
CXORF23 34
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562161 33
  • 79.81 (n)
mouse
(Mus musculus)
Mammalia A830080D01Rik 33 34
  • 78.53 (n)
Bclaf3 16
oppossum
(Monodelphis domestica)
Mammalia CXorf23 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1HXorf23 33
  • 69.24 (n)
CXorf23 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXorf23 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490423 33
  • 55.03 (n)
Species where no ortholog for BCLAF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCLAF3 Gene

ENSEMBL:
Gene Tree for BCLAF3 (if available)
TreeFam:
Gene Tree for BCLAF3 (if available)

Paralogs for BCLAF3 Gene

Paralogs for BCLAF3 Gene

genes like me logo Genes that share paralogs with BCLAF3: view

Variants for BCLAF3 Gene

Sequence variations from dbSNP and Humsavar for BCLAF3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000044649 -- 19,966,133(+) GTTGA(C/T)TGGGA nc-transcript-variant, reference, synonymous-codon
rs1000118738 -- 19,970,956(+) AATAC(A/G)AGCAC intron-variant, upstream-variant-2KB
rs1000177973 -- 19,986,665(+) AAACT(A/G)AGAAA intron-variant, downstream-variant-500B
rs1000234218 -- 19,983,582(+) TGGTG(A/G)CATGC intron-variant
rs1000240583 -- 19,959,121(+) ACAGG(A/T)CAAAG intron-variant, reference, stop-lost

Structural Variations from Database of Genomic Variants (DGV) for BCLAF3 Gene

Variant ID Type Subtype PubMed ID
nsv1110597 CNV duplication 24896259
nsv1140019 CNV duplication 24896259
nsv1150454 CNV duplication 26484159

Variation tolerance for BCLAF3 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCLAF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCLAF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCLAF3 Gene

Disorders for BCLAF3 Gene

Relevant External Links for BCLAF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCLAF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCLAF3

No disorders were found for BCLAF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCLAF3 Gene

Publications for BCLAF3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 60
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 60

Products for BCLAF3 Gene

Sources for BCLAF3 Gene

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