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Aliases for BCLAF1 Gene

Aliases for BCLAF1 Gene

  • BCL2-Associated Transcription Factor 1 2 3
  • BTF 3 4 6
  • KIAA0164 4 6
  • Bcl-2-Associated Transcription Factor 1 3
  • BK211L9.1 3

External Ids for BCLAF1 Gene

Summaries for BCLAF1 Gene

Entrez Gene Summary for BCLAF1 Gene

  • This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCLAF1 Gene

BCLAF1 (BCL2-Associated Transcription Factor 1) is a Protein Coding gene. An important paralog of this gene is CXorf23.

UniProtKB/Swiss-Prot for BCLAF1 Gene

  • Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Wiki entry for BCLAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCLAF1 Gene

Genomics for BCLAF1 Gene

Genomic Location for BCLAF1 Gene

Start:
136,256,863 bp from pter
End:
136,290,645 bp from pter
Size:
33,783 bases
Orientation:
Minus strand

Genomic View for BCLAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCLAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCLAF1 Gene

Regulatory Elements for BCLAF1 Gene

Proteins for BCLAF1 Gene

  • Protein details for BCLAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYF8-BCLF1_HUMAN
    Recommended name:
    Bcl-2-associated transcription factor 1
    Protein Accession:
    Q9NYF8
    Secondary Accessions:
    • A2RU75
    • B7ZM58
    • E1P586
    • Q14673
    • Q86WU6
    • Q86WY0

    Protein attributes for BCLAF1 Gene

    Size:
    920 amino acids
    Molecular mass:
    106122 Da
    Quaternary structure:
    • Interacts with Bcl-2 related proteins, EMD, with the adenovirus E1B 19 kDa protein and with DNA. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN.
    SequenceCaution:
    • Sequence=AAH47687.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47887.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH56894.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH63846.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA11481.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BCLAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCLAF1 Gene

Proteomics data for BCLAF1 Gene at MOPED

Post-translational modifications for BCLAF1 Gene

  • Citrullinated by PADI4.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys421, Lys517, Lys567, Lys593, Lys622, and Lys845

No data available for DME Specific Peptides for BCLAF1 Gene

Domains for BCLAF1 Gene

Protein Domains for BCLAF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCLAF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCLAF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BCLAF1 Gene

Function for BCLAF1 Gene

Molecular function for BCLAF1 Gene

UniProtKB/Swiss-Prot Function: Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.

Gene Ontology (GO) - Molecular Function for BCLAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 10330179
GO:0005515 protein binding IPI 10837489
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BCLAF1: view
genes like me logo Genes that share phenotypes with BCLAF1: view

Animal Models for BCLAF1 Gene

MGI Knock Outs for BCLAF1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCLAF1 Gene

Localization for BCLAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCLAF1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCLAF1 Gene COMPARTMENTS Subcellular localization image for BCLAF1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BCLAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BCLAF1: view

Pathways for BCLAF1 Gene

SuperPathways for BCLAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCLAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS 10330179
GO:0043065 positive regulation of apoptotic process IDA 10330179
GO:0043620 regulation of DNA-templated transcription in response to stress IMP 17938203
GO:0045892 negative regulation of transcription, DNA-templated TAS 10330179
genes like me logo Genes that share ontologies with BCLAF1: view

No data available for Pathways by source for BCLAF1 Gene

Transcripts for BCLAF1 Gene

Unigene Clusters for BCLAF1 Gene

BCL2-associated transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCLAF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for BCLAF1 Gene

GeneLoc Exon Structure for
BCLAF1
ECgene alternative splicing isoforms for
BCLAF1

Expression for BCLAF1 Gene

mRNA expression in normal human tissues for BCLAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCLAF1 Gene

SOURCE GeneReport for Unigene cluster for BCLAF1 Gene Hs.486542

mRNA Expression by UniProt/SwissProt for BCLAF1 Gene

Q9NYF8-BCLF1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with BCLAF1: view

No data available for mRNA differential expression in normal tissues for BCLAF1 Gene

Orthologs for BCLAF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCLAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCLAF1 35
  • 99.75 (n)
  • 99.89 (a)
BCLAF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCLAF1 35
  • 96.07 (n)
  • 98.15 (a)
BCLAF1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCLAF1 35
  • 96.69 (n)
  • 98.5 (a)
BCLAF1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bclaf1 35
  • 92.08 (n)
  • 96.29 (a)
Bclaf1 16
Bclaf1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BCLAF1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bclaf1 35
  • 91.59 (n)
  • 95.95 (a)
chicken
(Gallus gallus)
Aves BCLAF1 35
  • 86.6 (n)
  • 90.36 (a)
BCLAF1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCLAF1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24564 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bclaf1 35
  • 64.09 (n)
  • 54.43 (a)
Str.20167 35
Species with no ortholog for BCLAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCLAF1 Gene

ENSEMBL:
Gene Tree for BCLAF1 (if available)
TreeFam:
Gene Tree for BCLAF1 (if available)

Paralogs for BCLAF1 Gene

Paralogs for BCLAF1 Gene

Pseudogenes.org Pseudogenes for BCLAF1 Gene

genes like me logo Genes that share paralogs with BCLAF1: view

Variants for BCLAF1 Gene

Sequence variations from dbSNP and Humsavar for BCLAF1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14514 -- 136,258,717(-) AATTA(C/T)AATTT utr-variant-3-prime, nc-transcript-variant
rs703192 -- 136,288,138(+) AACAG(C/T)TTCCT intron-variant
rs703193 -- 136,288,212(+) TGAAA(C/T)ATGAA intron-variant
rs718185 -- 136,281,042(-) TCATC(C/T)TAGTA intron-variant
rs718186 -- 136,280,749(-) TATGT(C/G)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCLAF1 Gene

Variant ID Type Subtype PubMed ID
esv2732746 CNV Deletion 23290073
esv2732747 CNV Deletion 23290073
esv2673118 CNV Deletion 23128226
esv9082 CNV Loss 19470904
esv2732748 CNV Deletion 23290073
esv2732749 CNV Deletion 23290073
esv1925105 CNV Deletion 18987734
esv6857 CNV Loss 19470904
esv2732751 CNV Deletion 23290073
esv2732752 CNV Deletion 23290073
esv2732753 CNV Deletion 23290073
esv990963 CNV Deletion 20482838
esv2063708 CNV Deletion 18987734
dgv1063e201 CNV Deletion 23290073
dgv1064e201 CNV Deletion 23290073
dgv1065e201 CNV Deletion 23290073
esv2161601 CNV Deletion 18987734
esv4525 CNV Deletion 18987735

Relevant External Links for BCLAF1 Gene

HapMap Linkage Disequilibrium report
BCLAF1
Human Gene Mutation Database (HGMD)
BCLAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCLAF1 Gene

Disorders for BCLAF1 Gene

Relevant External Links for BCLAF1

Genetic Association Database (GAD)
BCLAF1
Human Genome Epidemiology (HuGE) Navigator
BCLAF1
genes like me logo Genes that share disorders with BCLAF1: view

No data available for UniProtKB/Swiss-Prot for BCLAF1 Gene

Publications for BCLAF1 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. (PMID: 10330179) Kasof G.M. … White E. (Mol. Cell. Biol. 1999) 2 3 4
  3. Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor. (PMID: 15681850) Mansharamani M. … Wilson K.L. (J. Biol. Chem. 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for BCLAF1 Gene

  • antibodies-online peptides for BCLAF1
  • antibodies-online antibodies for BCLAF1
  • antibodies-online kits for BCLAF1

Sources for BCLAF1 Gene

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