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Aliases for BCL9L Gene

Aliases for BCL9L Gene

  • B-Cell CLL/Lymphoma 9-Like 2 3
  • B-Cell Lymphoma 9-Like Protein 3 4
  • BCL9-Like Protein 3 4
  • Protein BCL9-2 3 4
  • DLNB11 3 4
  • Nuclear Co-Factor Of Beta-Catenin Signalling 3
  • B-Cell CLL/Lymphoma 9-Like Protein 3
  • BCL9-2 3

External Ids for BCL9L Gene

Previous GeneCards Identifiers for BCL9L Gene

  • GC11M118304
  • GC11M118272
  • GC11M118766
  • GC11M114706

Summaries for BCL9L Gene

GeneCards Summary for BCL9L Gene

BCL9L (B-Cell CLL/Lymphoma 9-Like) is a Protein Coding gene. Diseases associated with BCL9L include colorectal adenoma. Among its related pathways are Wnt signaling pathway (KEGG). GO annotations related to this gene include transcription coactivator activity and beta-catenin binding. An important paralog of this gene is BCL9.

UniProtKB/Swiss-Prot for BCL9L Gene

  • Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL9L Gene

Genomics for BCL9L Gene

Regulatory Elements for BCL9L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BCL9L Gene

Start:
118,893,875 bp from pter
End:
118,925,618 bp from pter
Size:
31,744 bases
Orientation:
Minus strand

Genomic View for BCL9L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL9L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL9L Gene

Proteins for BCL9L Gene

  • Protein details for BCL9L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UU0-BCL9L_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 9-like protein
    Protein Accession:
    Q86UU0
    Secondary Accessions:
    • A1A4C1
    • Q67FY1
    • Q6ZWJ0
    • Q6ZWK2

    Protein attributes for BCL9L Gene

    Size:
    1499 amino acids
    Molecular mass:
    157129 Da
    Quaternary structure:
    • Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1.
    SequenceCaution:
    • Sequence=AAH33257.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85512.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL9L Gene

    Alternative splice isoforms for BCL9L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL9L Gene

Proteomics data for BCL9L Gene at MOPED

Post-translational modifications for BCL9L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL9L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCL9L (Bcl-9L)

No data available for DME Specific Peptides for BCL9L Gene

Domains for BCL9L Gene

Protein Domains for BCL9L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL9L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UU0

UniProtKB/Swiss-Prot:

BCL9L_HUMAN :
  • Q86UU0
Domain:
  • Tne C-terminal domain is important for its transactivation activity.
Family:
  • Belongs to the BCL9 family.
genes like me logo Genes that share domains with BCL9L: view

No data available for Gene Families for BCL9L Gene

Function for BCL9L Gene

Molecular function for BCL9L Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).

Gene Ontology (GO) - Molecular Function for BCL9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 19328798
GO:0008013 beta-catenin binding IDA 15574752
genes like me logo Genes that share ontologies with BCL9L: view

Phenotypes for BCL9L Gene

MGI mutant phenotypes for BCL9L:
inferred from 1 alleles
GenomeRNAi human phenotypes for BCL9L:
genes like me logo Genes that share phenotypes with BCL9L: view

Animal Model Products

miRNA for BCL9L Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL9L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BCL9L Gene

Localization for BCL9L Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL9L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL9L Gene COMPARTMENTS Subcellular localization image for BCL9L gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BCL9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15574752
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with BCL9L: view

Pathways for BCL9L Gene

SuperPathways for BCL9L Gene

Superpath Contained pathways
1 Wnt signaling pathway (KEGG)
genes like me logo Genes that share pathways with BCL9L: view

Pathways by source for BCL9L Gene

1 R&D Systems pathway for BCL9L Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for BCL9L Gene

Gene Ontology (GO) - Biological Process for BCL9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010718 positive regulation of epithelial to mesenchymal transition IMP 19328798
GO:0022604 regulation of cell morphogenesis IMP 19328798
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP 19328798
GO:0035019 somatic stem cell maintenance IEA --
genes like me logo Genes that share ontologies with BCL9L: view

Transcripts for BCL9L Gene

Unigene Clusters for BCL9L Gene

B-cell CLL/lymphoma 9-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL9L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL9L Gene

No ASD Table

Relevant External Links for BCL9L Gene

GeneLoc Exon Structure for
BCL9L
ECgene alternative splicing isoforms for
BCL9L

Expression for BCL9L Gene

mRNA expression in normal human tissues for BCL9L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BCL9L Gene

This gene is overexpressed in Blymphocyte (28.2), Cervix (12.4), Frontal cortex (8.3), and Fetal gut (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL9L Gene

SOURCE GeneReport for Unigene cluster for BCL9L Gene Hs.414740

mRNA Expression by UniProt/SwissProt for BCL9L Gene

Q86UU0-BCL9L_HUMAN
Tissue specificity: Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.
genes like me logo Genes that share expressions with BCL9L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for BCL9L Gene

Orthologs for BCL9L Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL9L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BCL9L 35
  • 92.22 (n)
  • 95.18 (a)
BCL9L 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL9L 35
  • 91.84 (n)
  • 95.59 (a)
BCL9L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl9l 35
  • 89.11 (n)
  • 92.97 (a)
Bcl9l 16
Bcl9l 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCL9L 35
  • 99.32 (n)
  • 99.32 (a)
BCL9L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl9l 35
  • 88.89 (n)
  • 92.86 (a)
oppossum
(Monodelphis domestica)
Mammalia BCL9L 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCL9L 35
  • 72.74 (n)
  • 73.61 (a)
BCL9L 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL9L 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl9l 35
  • 59.47 (n)
  • 56.43 (a)
zebrafish
(Danio rerio)
Actinopterygii bcl9l 35
  • 57.01 (n)
  • 52.9 (a)
bcl9l 36
  • 40 (a)
OneToOne
Species with no ortholog for BCL9L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL9L Gene

ENSEMBL:
Gene Tree for BCL9L (if available)
TreeFam:
Gene Tree for BCL9L (if available)

Paralogs for BCL9L Gene

Paralogs for BCL9L Gene

genes like me logo Genes that share paralogs with BCL9L: view

Variants for BCL9L Gene

Sequence variations from dbSNP and Humsavar for BCL9L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs519925 -- 118,897,060(-) CCTCT(G/T)CCCAG utr-variant-3-prime
rs585123 -- 118,914,653(-) ACTGA(C/G)ACCAG intron-variant
rs694769 -- 118,897,721(-) GTTAT(G/T)GCTCC utr-variant-3-prime
rs2509047 -- 118,913,535(+) TACCC(A/T)ATCCC intron-variant
rs2510899 -- 118,926,574(-) TTCAT(G/T)GCCTC upstream-variant-2KB

Relevant External Links for BCL9L Gene

HapMap Linkage Disequilibrium report
BCL9L
Human Gene Mutation Database (HGMD)
BCL9L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCL9L Gene

Disorders for BCL9L Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BCL9L Gene in MalaCards »

(1) Diseases for BCL9L Gene including...

Relevant External Links for BCL9L

Genetic Association Database (GAD)
BCL9L
genes like me logo Genes that share disorders with BCL9L: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BCL9L Gene

Publications for BCL9L Gene

  1. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. (PMID: 12964048) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 23
  2. BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. (PMID: 17113272) Hoffmans R. … Basler K. (Mech. Dev. 2007) 3 4 23
  3. Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. (PMID: 15371335) Brembeck F.H. … Birchmeier W. (Genes Dev. 2004) 3 4
  4. Crystal structure of a beta-catenin/BCL9/Tcf4 complex. (PMID: 17052462) Sampietro J. … Xu W. (Mol. Cell 2006) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for BCL9L Gene

Sources for BCL9L Gene

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