Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BCL9L Gene

protein-coding   GIFtS: 50
GCID: GC11M118766

B-Cell CLL/Lymphoma 9-Like

  See BCL9L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
B-Cell CLL/Lymphoma 9-Like1 2     BCL9-Like Protein2 3
Protein BCL9-22 3     BCL9-22
DLNB112 3     B-Cell CLL/Lymphoma 9-Like Protein2
B-Cell Lymphoma 9-Like Protein2 3     Nuclear Co-Factor Of Beta-Catenin Signalling2

External Ids:    HGNC: 236881   Entrez Gene: 2831492   Ensembl: ENSG000001861747   OMIM: 6090045   UniProtKB: Q86UU03   

Export aliases for BCL9L gene to outside databases

Previous GC identifers: GC11M118304 GC11M118272 GC11M114706


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for BCL9L Gene:
BCL9L (B-cell CLL/lymphoma 9-like) is a protein-coding gene. Diseases associated with BCL9L include colorectal adenoma. GO annotations related to this gene include transcription coactivator activity and beta-catenin binding. An important paralog of this gene is BCL9.

UniProtKB/Swiss-Prot: BCL9L_HUMAN, Q86UU0
Function: Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity.
Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCL9L gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   E47   c-Ets-1   E2F   E2F-1   Hand1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BCL9L promoter sequence
   Search Chromatin IP Primers for BCL9L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL9L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

BCL9L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL9L gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118766:  view genomic region     (about GC identifiers)

Start:
118,764,584 bp from pter      End:
118,796,317 bp from pter
Size:
31,734 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BCL9L_HUMAN, Q86UU0 (See protein sequence)
Recommended Name: B-cell CLL/lymphoma 9-like protein  
Size: 1499 amino acids; 157129 Da
Subunit: Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1
Sequence caution: Sequence=AAH33257.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC85500.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC85512.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for BCL9L:
2XB1 (3D)    
Secondary accessions: A1A4C1 Q67FY1 Q6ZWJ0 Q6ZWK2
Alternative splicing: 4 isoforms:  Q86UU0-1   Q86UU0-2   Q86UU0-3   Q86UU0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCL9L: NX_Q86UU0

Explore proteomics data for BCL9L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BCL9L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872363.1  
    ENSEMBL proteins: 
     ENSP00000335320   ENSP00000432804  
    Reactome Protein details: Q86UU0

    BCL9L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BCL9L
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BCL9L
    GenScript Custom Purified and Recombinant Proteins Services for BCL9L
    Novus Biologicals BCL9L Proteins
    Novus Biologicals BCL9L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for BCL9L 

    BCL9L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BCL9L (Bcl9-2)
    OriGene Antibodies for BCL9L
    OriGene Custom Antibody Services for BCL9L
    Novus Biologicals BCL9L Antibodies
    Search for Antibodies for BCL9L at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for BCL9L
    LSBio Antibodies in human, mouse, rat for BCL9L

    BCL9L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCL9L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCL9L
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for BCL9L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR015668 Bcl-9
     IPR024670 BCL9_beta-catenin-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q86UU0

    ProtoNet protein and cluster: Q86UU0

    UniProtKB/Swiss-Prot: BCL9L_HUMAN, Q86UU0
    Domain: Tne C-terminal domain is important for its transactivation activity (By similarity)
    Similarity: Belongs to the BCL9 family


    Find genes that share domains with BCL9L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL9L_HUMAN, Q86UU0
    Function: Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity.
    Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS19328798
    GO:0008013beta-catenin binding IDA15574752
         
    Find genes that share ontologies with BCL9L           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BCL9L:
     Decreased Wnt reporter activit  Wnt reporter downregulated 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Bcl9l):
     muscle 

    Find genes that share phenotypes with BCL9L           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL9L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCL9L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL9L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL9L

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCL9L:
    hsa-mir-7-5p (MIRT025830), hsa-mir-331-3p (MIRT043506), hsa-mir-320b (MIRT036179), hsa-mir-92a-3p (MIRT049213), hsa-mir-193b-3p (MIRT041321)

    Block miRNA regulation of human, mouse, rat BCL9L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL9L (see all 74):
    hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-138-2* hsa-miR-637 hsa-miR-761 hsa-miR-34c-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidBCL9L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BCL9L
    Predesigned siRNA for gene silencing in human, mouse, rat BCL9L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCL9L

    Clone
    Products:
         
    OriGene clones in human, mouse for BCL9L (see all 7)
    OriGene ORF clones in mouse, rat for BCL9L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCL9L (NM_182557)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL9L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL9L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCL9L
    Browse ESI BIO Cell Lines and PureStem Progenitors for BCL9L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL9L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BCL9L_HUMAN, Q86UU0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15574752

    Find genes that share ontologies with BCL9L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BCL9L About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40


    Find genes that share SuperPaths with BCL9L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BCL9L
        Wnt Signaling Pathways


    2 Reactome Pathways for BCL9L
        deactivation of the beta-catenin transactivating complex
    formation of the beta-catenin:TCF transactivating complex


        Pathway & Disease-focused RT2 Profiler PCR Array including BCL9L: 
              Stem Cell Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL9L

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for BCL9L (Q86UU02, 3 ENSP000003353204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    --P310162MINT-8105937 MINT-8106343
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0010718positive regulation of epithelial to mesenchymal transition IMP19328798
    GO:0022604regulation of cell morphogenesis IMP19328798
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IMP19328798
    GO:0035019somatic stem cell maintenance IEA--

    Find genes that share ontologies with BCL9L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCL9L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BCL9L gene: 
    NM_182557.2  

    Unigene Cluster for BCL9L:

    B-cell CLL/lymphoma 9-like
    Hs.414740  [show with all ESTs]
    Unigene Representative Sequence: NM_182557
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334801(uc001pug.3 uc009zal.3) ENST00000526143 ENST00000526514
    ENST00000530293 ENST00000527266 ENST00000532899
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BCL9L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL9L (see all 74):
    hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-138-2* hsa-miR-637 hsa-miR-761 hsa-miR-34c-5p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidBCL9L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BCL9L
    Predesigned siRNA for gene silencing in human, mouse, rat BCL9L
    Clone
    Products:
         
    OriGene clones in human, mouse for BCL9L (see all 7)
    OriGene ORF clones in mouse, rat for BCL9L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCL9L (NM_182557)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL9L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL9L
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BCL9L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCL9L
      QuantiTect SYBR Green Assays in human, mouse, rat BCL9L
      QuantiFast Probe-based Assays in human, mouse, rat BCL9L

    Additional mRNA sequence: 

    AB094091.1 AK122650.1 AK122882.1 AY296059.1 BC033257.1 

    7 DOTS entries:

    DT.40250888  DT.100671753  DT.40109977  DT.95335895  DT.120727423  DT.212254  DT.40250893 

    Selected AceView cDNA sequences (see all 135):

    BU624696 BU170053 AY296059 AL534956 BM466326 BQ937674 AK122882 AI921203 
    BU624631 AW295172 BF476567 AB094091 NM_182557 BQ226630 AI348687 BQ931752 
    BU729067 CR606474 BQ671127 BF438189 AA470525 AW024061 AI298130 AK122650 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BCL9L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BCL9L Expression
    About this image


    BCL9L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Zeugopod Long Bone
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Meckel's Cartilage
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    BCL9L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL9L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414740

    UniProtKB/Swiss-Prot: BCL9L_HUMAN, Q86UU0
    Tissue specificity: Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal
    adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate,
    pancreatic and prostate cancers, head and neck tumors and embryonal tumor

        Pathway & Disease-focused RT2 Profiler PCR Array including BCL9L: 
              Stem Cell Signaling in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BCL9L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCL9L
    QuantiTect SYBR Green Assays in human, mouse, rat BCL9L
    QuantiFast Probe-based Assays in human, mouse, rat BCL9L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL9L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for BCL9L gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl9l1 , 5 B cell CLL/lymphoma 9-like1, 5 89.11(n)1
    92.97(a)1
      9 (24.84 cM)5
    802881  NM_030256.21  NP_084532.21 
     444991365 
    chicken
    (Gallus gallus)
    Aves BCL9L1 B-cell CLL/lymphoma 9-like 72.74(n)
    73.61(a)
      419785  XM_004948130.1  XP_004948187.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL9L6
    B-cell CLL/lymphoma 9-like
    62(a)
    1 ↔ 1
    GL344088.1(4915-15100)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bcl9l1 B-cell CLL/lymphoma 9-like 59.47(n)
    56.43(a)
      100495254  XM_002932924.2  XP_002932970.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bcl9l1 B-cell CLL/lymphoma 9-like 57.01(n)
    52.9(a)
      449532  NM_001005575.1  NP_001005575.1 


    ENSEMBL Gene Tree for BCL9L (if available)
    TreeFam Gene Tree for BCL9L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BCL9L gene
    BCL92  

    Find genes that share paralogs with BCL9L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BCL9L (see all 404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754380461,2
    C,F--118767564(+) CTCCCG/AAGGCA 1 -- ut311Minor allele frequency- A:0.01EA 120
    rs1810365451,2
    --118767605(+) TTACTC/TCTGGG 1 -- ut310--------
    rs1164546801,2
    C,F--118767666(+) AAAGGC/TGGATA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs5199251,2
    H--118767769(-) CCTCTG/TCCCAG 1 -- ut31 ese35Minor allele frequency- T:0.00MN NS EA 598
    rs1159266451,2
    C,F--118767811(+) AGGAGG/ACGGCA 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs735754111,2
    C,F--118767832(+) TCCCCG/AATTCC 1 -- ut312Minor allele frequency- A:0.50WA 4
    rs783483291,2
    C,F--118767925(+) CAGCAG/ACCTCT 1 -- ut312Minor allele frequency- A:0.05WA 120
    rs1472833861,2
    --118768029(+) GGGGG-/CCCACA 1 -- ut310--------
    rs1855007741,2
    --118768100(+) GGCTAA/TGATGT 1 -- ut310--------
    rs1898454131,2
    --118768182(+) ATGCAA/CGTGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BCL9L (118764584 - 118796317 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BCL9L: --
    Human Gene Mutation Database (HGMD): BCL9L
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL9L
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL9L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609004    OMIM disorders: --

    1 disease for BCL9L:    
    About MalaCards
    colorectal adenoma


    Find genes that share disorders with BCL9L           About GenesLikeMe

    Genetic Association Database (GAD): BCL9L

    Export disorders for BCL9L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BCL9L gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with BCL9L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. (PubMed id 12964048)1, 2, 3, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
    2. BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. (PubMed id 17113272)1, 2, 9 Hoffmans R. and Basler K. (Mech. Dev. 2007)
    3. Crystal structure of a beta-catenin/BCL9/Tcf4 complex. (PubMed id 17052462)1, 2 Sampietro J.... Xu W. (Mol. Cell 2006)
    4. Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. (PubMed id 15371335)1, 2 Brembeck F.H.... Birchmeier W. (Genes Dev. 2004)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. Identification of a link between Wnt/I^-catenin signalling and the cell fusion pathway. (PubMed id 22109522)1 Matsuura K....Akiyama T. (Nat Commun 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. BCL9-2 promotes early stages of intestinal tumor progression. (PubMed id 21703997)1 Brembeck F.H....Birchmeier W. (Gastroenterology 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 283149 HGNC: 23688 AceView: BCL9L Ensembl:ENSG00000186174 euGenes: HUgn283149
    ECgene: BCL9L H-InvDB: BCL9L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BCL9L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL9L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BCL9L gene:
    Search GeneIP for patents involving BCL9L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for BCL9L (Bcl9-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BCL9L   OriGene RNAi products in human, mouse, rat for BCL9L  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for BCL9L  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BCL9L  
     OriGene qSTAR qPCR primer pairs in human, mouse for BCL9L   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BCL9L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCL9L   OriGene Custom Protein Services for BCL9L  

     
     
     Block miRNA regulation of human, mouse, rat BCL9L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BCL9L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL9L Predesigned siRNA for gene silencing in human, mouse, rat BCL9L
     QuantiFast Probe-based Assays in human, mouse, rat BCL9L QuantiTect SYBR Green Assays in human, mouse, rat BCL9L
     PCR Arrays including human, mouse, rat BCL9L Search Chromatin IP Primers for BCL9L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCL9L  GeneGlobe Interaction Network for BCL9L
     Regulatory tfbs in BCL9L promoter
     GenScript Custom Purified and Recombinant Proteins Services for BCL9L GenScript cDNA clones with any tag delivered in your preferred vector for BCL9L
     GenScript Custom Assay Services for BCL9L GenScript Custom overexpressing Cell Line Services for BCL9L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BCL9L
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BCL9L antibodies
     BCL9L proteins
     BCL9L lysates
     Search for Antibodies for BCL9L at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for BCL9L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for BCL9L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL9L
     SwitchGear 3'UTR luciferase reporter plasmids for BCL9L
     SwitchGear Promoter luciferase reporter plasmids for BCL9L
     ThermoFisher Antibodies for BCL9L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL9L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL9L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCL9L
     LSBio Antibodies in human, mouse, rat for BCL9L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BCL9L
      Search eBioscience for proteins for BCL9L
      Search eBioscience for elisas for BCL9L
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCL9L gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4