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Aliases for BCL9L Gene

Aliases for BCL9L Gene

  • B-Cell CLL/Lymphoma 9-Like 2 3 5
  • B-Cell Lymphoma 9-Like Protein 3 4
  • BCL9-Like Protein 3 4
  • Protein BCL9-2 3 4
  • DLNB11 3 4
  • Nuclear Co-Factor Of Beta-Catenin Signalling 3
  • BCL9-2 3

External Ids for BCL9L Gene

Previous GeneCards Identifiers for BCL9L Gene

  • GC11M118304
  • GC11M118272
  • GC11M118766
  • GC11M114706

Summaries for BCL9L Gene

GeneCards Summary for BCL9L Gene

BCL9L (B-Cell CLL/Lymphoma 9-Like) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. GO annotations related to this gene include transcription coactivator activity and beta-catenin binding. An important paralog of this gene is BCL9.

UniProtKB/Swiss-Prot for BCL9L Gene

  • Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL9L Gene

Genomics for BCL9L Gene

Regulatory Elements for BCL9L Gene

Genomic Location for BCL9L Gene

Chromosome:
11
Start:
118,893,875 bp from pter
End:
118,925,618 bp from pter
Size:
31,744 bases
Orientation:
Minus strand

Genomic View for BCL9L Gene

Genes around BCL9L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL9L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL9L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL9L Gene

Proteins for BCL9L Gene

  • Protein details for BCL9L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UU0-BCL9L_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 9-like protein
    Protein Accession:
    Q86UU0
    Secondary Accessions:
    • A1A4C1
    • Q67FY1
    • Q6ZWJ0
    • Q6ZWK2

    Protein attributes for BCL9L Gene

    Size:
    1499 amino acids
    Molecular mass:
    157129 Da
    Quaternary structure:
    • Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1.
    SequenceCaution:
    • Sequence=AAH33257.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85512.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL9L Gene

    Alternative splice isoforms for BCL9L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL9L Gene

Proteomics data for BCL9L Gene at MOPED

Post-translational modifications for BCL9L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL9L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCL9L (Bcl-9L)

No data available for DME Specific Peptides for BCL9L Gene

Domains & Families for BCL9L Gene

Protein Domains for BCL9L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL9L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UU0

UniProtKB/Swiss-Prot:

BCL9L_HUMAN :
  • Tne C-terminal domain is important for its transactivation activity.
  • Belongs to the BCL9 family.
Domain:
  • Tne C-terminal domain is important for its transactivation activity.
Family:
  • Belongs to the BCL9 family.
genes like me logo Genes that share domains with BCL9L: view

No data available for Gene Families for BCL9L Gene

Function for BCL9L Gene

Molecular function for BCL9L Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).

Gene Ontology (GO) - Molecular Function for BCL9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008013 beta-catenin binding IEA,IDA 15574752
genes like me logo Genes that share ontologies with BCL9L: view
genes like me logo Genes that share phenotypes with BCL9L: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL9L Gene

Localization for BCL9L Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL9L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL9L Gene COMPARTMENTS Subcellular localization image for BCL9L gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for BCL9L Gene

Pathways & Interactions for BCL9L Gene

genes like me logo Genes that share pathways with BCL9L: view

Interacting Proteins for BCL9L Gene

Gene Ontology (GO) - Biological Process for BCL9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010718 positive regulation of epithelial to mesenchymal transition IMP 19328798
GO:0035019 somatic stem cell population maintenance IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IMP 19328798
GO:0060070 canonical Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with BCL9L: view

No data available for SIGNOR curated interactions for BCL9L Gene

Drugs & Compounds for BCL9L Gene

No Compound Related Data Available

Transcripts for BCL9L Gene

Unigene Clusters for BCL9L Gene

B-cell CLL/lymphoma 9-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL9L Gene

No ASD Table

Relevant External Links for BCL9L Gene

GeneLoc Exon Structure for
BCL9L
ECgene alternative splicing isoforms for
BCL9L

Expression for BCL9L Gene

mRNA expression in normal human tissues for BCL9L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCL9L Gene

This gene is overexpressed in Blymphocyte (28.2), Cervix (12.4), Frontal cortex (8.3), and Fetal gut (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL9L Gene



SOURCE GeneReport for Unigene cluster for BCL9L Gene Hs.414740

mRNA Expression by UniProt/SwissProt for BCL9L Gene

Q86UU0-BCL9L_HUMAN
Tissue specificity: Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.
genes like me logo Genes that share expression patterns with BCL9L: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for BCL9L Gene

Orthologs for BCL9L Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL9L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL9L 36
  • 99 (a)
OneToOne
BCL9L 35
  • 99.32 (n)
  • 99.32 (a)
cow
(Bos Taurus)
Mammalia BCL9L 36
  • 95 (a)
OneToOne
BCL9L 35
  • 92.22 (n)
  • 95.18 (a)
dog
(Canis familiaris)
Mammalia BCL9L 35
  • 91.84 (n)
  • 95.59 (a)
BCL9L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl9l 16
Bcl9l 36
  • 94 (a)
OneToOne
Bcl9l 35
  • 89.11 (n)
  • 92.97 (a)
oppossum
(Monodelphis domestica)
Mammalia BCL9L 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl9l 35
  • 88.89 (n)
  • 92.86 (a)
chicken
(Gallus gallus)
Aves BCL9L 35
  • 72.74 (n)
  • 73.61 (a)
BCL9L 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL9L 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl9l 35
  • 59.47 (n)
  • 56.43 (a)
zebrafish
(Danio rerio)
Actinopterygii bcl9l 36
  • 40 (a)
OneToOne
bcl9l 35
  • 57.01 (n)
  • 52.9 (a)
Species with no ortholog for BCL9L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL9L Gene

ENSEMBL:
Gene Tree for BCL9L (if available)
TreeFam:
Gene Tree for BCL9L (if available)

Paralogs for BCL9L Gene

Paralogs for BCL9L Gene

genes like me logo Genes that share paralogs with BCL9L: view

Variants for BCL9L Gene

Sequence variations from dbSNP and Humsavar for BCL9L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs585123 -- 118,914,653(-) ACTGA(C/G)ACCAG intron-variant
rs2509047 -- 118,913,535(+) TACCC(A/T)ATCCC intron-variant
rs2510899 -- 118,926,574(-) TTCAT(G/T)GCCTC upstream-variant-2KB
rs2510900 -- 118,926,518(-) GTGTG(A/T)GAGAG upstream-variant-2KB
rs7102433 -- 118,916,120(+) GTAGC(A/G)AGGCA intron-variant

Variation tolerance for BCL9L Gene

Residual Variation Intolerance Score: 2.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.79; 73.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL9L Gene

HapMap Linkage Disequilibrium report
BCL9L
Human Gene Mutation Database (HGMD)
BCL9L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCL9L Gene

Disorders for BCL9L Gene

Relevant External Links for BCL9L

Genetic Association Database (GAD)
BCL9L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL9L

No disorders were found for BCL9L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL9L Gene

Publications for BCL9L Gene

  1. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. (PMID: 12964048) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 23 67
  2. BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. (PMID: 17113272) Hoffmans R. … Basler K. (Mech. Dev. 2007) 3 23
  3. The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis. (PMID: 25149534) Zatula N. … Brembeck F.H. (Oncotarget 2014) 3
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  5. LATS2 suppresses oncogenic Wnt signaling by disrupting I^-catenin/BCL9 interaction. (PMID: 24360964) Li J. … Wang C.Y. (Cell Rep 2013) 3

Products for BCL9L Gene

Sources for BCL9L Gene

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