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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL9 Gene

protein-coding   GIFtS: 59
GCID: GC01P147013

B-Cell CLL/Lymphoma 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 91 2     B-Cell CLL/Lymphoma 9 Protein2
Protein Legless Homolog2 3     bcl-92
B-Cell Lymphoma 9 Protein2 3     Bcl-93
LGS2     

External Ids:    HGNC: 10081   Entrez Gene: 6072   Ensembl: ENSG000001161287   OMIM: 6025975   UniProtKB: O005123   

Export aliases for BCL9 gene to outside databases

Previous GC identifers: GC01P145227 GC01P143738 GC01P144357 GC01P144520 GC01P144237 GC01P145479 GC01P120426


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL9 Gene:
BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell
malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic
significance in B-cell malignancies. (provided by RefSeq, Jul 2008)

GeneCards Summary for BCL9 Gene: 
BCL9 (B-cell CLL/lymphoma 9) is a protein-coding gene. Diseases associated with BCL9 include b-cell lymphomas, and acute lymphoblastic leukemia, and among its related super-pathways are Wnt signaling pathway. GO annotations related to this gene include protein binding and beta-catenin binding. An important paralog of this gene is BCL9L.

UniProtKB/Swiss-Prot: BCL9_HUMAN, O00512
Function: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional
activity (By similarity)

Gene Wiki entry for BCL9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167185.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL9 gene promoter:
         STAT1   NF-1/L   NF-1   GR-beta   CUTL1   GATA-1   PPAR-gamma1   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL9 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

BCL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P147013:  view genomic region     (about GC identifiers)

Start:
147,013,182 bp from pter      End:
147,098,017 bp from pter
Size:
84,836 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BCL9_HUMAN, O00512 (See protein sequence)
Recommended Name: B-cell CLL/lymphoma 9 protein  
Size: 1426 amino acids; 149290 Da
Subunit: Binds to beta-catenin (CTNNB1), PYGO1 and PYGO2
Subcellular location: Nucleus (By similarity)
Caution: It is uncertain whether Met-1 or Met-27 is the initiator
Sequence caution: Sequence=CAA73942.1; Type=Frameshift; Positions=1391;
6/7 PDB 3D structures from and Proteopedia for BCL9 (see all 7):
2GL7 (3D)        2VP7 (3D)        2VPB (3D)        2VPD (3D)        2VPE (3D)        2VPG (3D)    
Secondary accessions: Q5T489

Explore the universe of human proteins at neXtProt for BCL9: NX_O00512

Explore proteomics data for BCL9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00512

  • BCL9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCL9 Protein Expression
    REFSEQ proteins: NP_004317.2  
    ENSEMBL proteins: 
     ENSP00000234739  

    Human Recombinant Protein Products for BCL9: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--

    BCL9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR024670 BCL9_beta-catenin-bd_dom
     IPR015668 Bcl-9

    Graphical View of Domain Structure for InterPro Entry O00512

    ProtoNet protein and cluster: O00512

    UniProtKB/Swiss-Prot: BCL9_HUMAN, O00512
    Similarity: Belongs to the BCL9 family


    BCL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL9_HUMAN, O00512
    Function: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional
    activity (By similarity)

         Genatlas biochemistry entry for BCL9:
    gene coding for a large proline-rich protein with two transcripts,expressed in all tissues and a third expressed
    only in thymus,spleen,small intestine,involved in translocation t(1;14) and t(1;22)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11955446
    GO:0008013beta-catenin binding IEA--
         
    BCL9 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BCL9:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased cell transformation 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Bcl9):
     muscle 

    BCL9 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCL9 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL9 
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    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL9 (see all 46):
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    SwitchGear 3'UTR luciferase reporter plasmidBCL9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCL9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt Signaling Pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2WNT Signaling
    WNT Signaling
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BCL9
        Wnt Signaling Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BCL9
        WNT Signaling

    2 BioSystems Pathways for BCL9
        Wnt Signaling Pathway NetPath
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for BCL9 (O005121, 2, 3 ENSP000002347394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC73Q6P1J91, 3, ENSP000003564054EBI-533127,EBI-930143 I2D: score=2 STRING: ENSP00000356405
    PYGO1Q9Y3Y41, 3, ENSP000003023274EBI-533127,EBI-3397474 I2D: score=4 STRING: ENSP00000302327
    CTNNB1P352221, 3, ENSP000003444564EBI-533127,EBI-491549 I2D: score=5 STRING: ENSP00000344456
    PYGO2Q9BRQ02, 3, ENSP000003574424MINT-8183368 I2D: score=2 STRING: ENSP00000357442
    TCF4P158843, ENSP000003464404I2D: score=2 STRING: ENSP00000346440
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014908myotube differentiation involved in skeletal muscle regeneration IEA--
    GO:0017015NOT regulation of transforming growth factor beta receptor signaling pathway IMP19328798
    GO:0035019somatic stem cell maintenance IEA--
    GO:0035914skeletal muscle cell differentiation ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    BCL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCL9

    Search CenterWatch for drugs/clinical trials and news about BCL9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCL9 gene: 
    NM_004326.3  

    Unigene Cluster for BCL9:

    B-cell CLL/lymphoma 9
    Hs.415209  [show with all ESTs]
    Unigene Representative Sequence: NM_004326
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234739(uc010ozr.1 uc001epq.3) ENST00000497938 ENST00000473292

    miRNA
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    hsa-miR-140-5p hsa-miR-548j hsa-miR-188-5p hsa-miR-605 hsa-miR-30d hsa-miR-218 hsa-miR-3921 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidBCL9 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL9

    Additional mRNA sequence: 

    BC115016.1 BC115017.1 BC115018.1 BC115019.1 BC116451.1 Y13620.1 

    6 DOTS entries:

    DT.311064  DT.65286142  DT.95152086  DT.95254678  DT.430753  DT.75151309 

    24/106 AceView cDNA sequences (see all 106):

    BM701828 BU689763 BU931046 CR597072 AI391511 AI467999 BG107403 AA515870 
    BU845594 BF751695 AW008730 AW104430 BQ683054 BE018332 AI858878 AA665891 
    BU854880 AI452504 BG825575 AI379590 AW243387 BF115910 AL569759 BG011142 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BCL9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:        -                                                                           
    SP2:                                                                                    
    SP3:                                                  -                                 


    ECgene alternative splicing isoforms for BCL9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL9 expression in normal human tissues (normalized intensities)      BCL9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTAAGACGT
    BCL9 Expression
    About this image


    BCL9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon

    See BCL9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL9

    SOURCE GeneReport for Unigene cluster: Hs.415209

    UniProtKB/Swiss-Prot: BCL9_HUMAN, O00512
    Tissue specificity: Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower
    levels in spleen, colon and blood

        SABiosciences Expression via Pathway-Focused PCR Arrays including BCL9: 
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BCL9 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl91 , 5 B cell CLL/lymphoma 91, 5 92.87(n)1
    95.37(a)1
      3 (42.04 cM)5
    775781  NM_029933.41  NP_084209.31 
     972036625 
    chicken
    (Gallus gallus)
    Aves BCL91 B-cell CLL/lymphoma 9 82.01(n)
    87.81(a)
      418456  XM_416666.3  XP_416666.2 
    lizard
    (Anolis carolinensis)
    Reptilia BCL96
    Uncharacterized protein
    84(a)
    1 ↔ 1
    3(162122064-162153631)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24262 Xenopus laevis transcribed sequence with moderate similarity more 80.57(n)    AW645530.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bcl91 B-cell CLL/lymphoma 9 64.33(n)
    64.25(a)
      449616  NM_001005604.1  NP_001005604.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DLP6
    Ncoa66
    (see all 8)
    --
    6(a)
    5(a)
    (see all 8)
    possible ortholog
    possible ortholog
    (see all 8)
    2L(6480956-6487585)
    2L(5315426-5326683)
    worm
    (Caenorhabditis elegans)
    Secernentea nra-36
    pqn-206
    (see all 9)
    Protein PQN-20
    (see all 9)
    8(a)
    5(a)
    (see all 9)
    possible ortholog
    possible ortholog
    (see all 9)
    X(9925923-9931460)
    I(6791025-6797470)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GAL116
    Subunit of the RNA polymerase II mediator complex;...
    1(a)
    1 → many
    XV(234940-238185)


    ENSEMBL Gene Tree for BCL9 (if available)
    TreeFam Gene Tree for BCL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCL9 gene
    BCL9L2  

    BCL9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BCL9
    PGOHUM00000235614


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1634 SNPs in BCL9 are shown (see all 1634)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453802591,2
    C--147011185(+) GAGTAC/TCTGGA 1 -- us2k10--------
    rs1924919051,2
    --147011218(+) TATGGC/TGGGTA 1 -- us2k10--------
    rs741257241,2
    C,F--147011219(+) ATGGCG/AGGTAA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1476646751,2
    --147011324(+) TGCCTC/TGTTTT 1 -- us2k10--------
    rs1398259071,2
    C--147011329(+) CGTTTG/TTCTAT 1 -- us2k10--------
    rs1837299161,2
    --147011384(+) CAAATC/GAGTGG 1 -- us2k10--------
    rs1881016041,2
    C--147011418(+) TACTTA/TAAAAA 1 -- us2k10--------
    rs2014885601,2
    --147011427(+) AAAGG-/TTATTATT 1 -- us2k10--------
    rs557764251,2
    C,F--147011447(+) TTATAT/CTACCA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1917513891,2
    --147011476(+) GAGTCA/GGGACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCL9 (147013182 - 147098017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BCL9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663751CNV Deletion23128226
    nsv831426CNV Loss17160897
    nsv831414CNV Gain17160897
    nsv872266CNV Gain21882294
    nsv7181OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): BCL9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL9
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602597    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCL9_HUMAN, O00512
  • Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute
    lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact,
    but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of
    translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies

  • 12 diseases for BCL9:    About MalaCards
    b-cell lymphomas    acute lymphoblastic leukemia    lymphoblastic leukemia    skeletal muscle regeneration
    atrioventricular septal defect    leukemia    oral squamous cell carcinoma    chronic lymphocytic leukemia
    squamous cell carcinoma    colorectal cancer    ovarian cancer    prostatitis


    BCL9 for disorders           About GeneDecksing

    Genatlas disease: BCL9
    B-cell CLL ,chronic lymphocytic leukemia with translocation t(1;14)(q21;q32),t(1;22)(q21;q11)

    Genetic Association Database (GAD): BCL9
    Human Genome Epidemiology (HuGE) Navigator: BCL9 (6 documents)

    Export disorders for BCL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL9 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with BCL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. (PubMed id 9490669)1, 2, 3, 9 Willis T.G....Dyer M.J.S. (1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. (PubMed id 11955446)1, 2 Kramps T.... Basler K. (2002)
    5. Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin. (PubMed id 18347063)1, 9 Sustmann C....Grosschedl R. (2008)
    6. BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. (PubMed id 17113272)1, 9 Hoffmans R. and Basler K. (2007)
    7. BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. (PubMed id 23382809)1 Xu C....Wang K. (2013)
    8. Targeted disruption of the BCL9/b-catenin complex inhi bits oncogenic Wnt signaling. (PubMed id 22914623)1 Takada K....Carrasco D.R. (2012)
    9. MicroRNA-30c-2* expressed in ovarian cancer cells supp resses growth factor-induced cellular proliferation and downregulates the oncoge ne BCL9. (PubMed id 22024689)1 Jia W....Murph M.M. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 607 HGNC: 1008 AceView: BCL9 Ensembl:ENSG00000116128 euGenes: HUgn607
    ECgene: BCL9 H-InvDB: BCL9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCL9 gene:
    Search GeneIP for patents involving BCL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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