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Aliases for BCL7C Gene

Aliases for BCL7C Gene

  • BCL Tumor Suppressor 7C 2 3 5
  • B-Cell CLL/Lymphoma 7C 2

External Ids for BCL7C Gene

Previous GeneCards Identifiers for BCL7C Gene

  • GC16P9B0085
  • GC16M031396
  • GC16M030896
  • GC16M030935
  • GC16M030806
  • GC16M030847

Summaries for BCL7C Gene

Entrez Gene Summary for BCL7C Gene

  • This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for BCL7C Gene

BCL7C (BCL Tumor Suppressor 7C) is a Protein Coding gene. Diseases associated with BCL7C include Lymphoma. An important paralog of this gene is BCL7B.

UniProtKB/Swiss-Prot for BCL7C Gene

  • May play an anti-apoptotic role.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL7C Gene

Genomics for BCL7C Gene

Regulatory Elements for BCL7C Gene

Enhancers for BCL7C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F030052 0.2 ENCODE 66.5 +840.8 840756 3.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 ZNF747 ZNF764 SMG1P2 NPIPB13 BCL7C ZNF785 PRR14 ZNF629 ZNF689 ENSG00000235560
GH16F030555 1.2 Ensembl ENCODE 56.7 +336.9 336889 4.2 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC ENSG00000260267 ZNF764 SMG1P2 NPIPB13 ENSG00000260304 ZNF785 BCL7C MIR762HG ENSG00000261474 PRR14
GH16F030785 0.2 ENCODE 48.8 +108.2 108223 3.4 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000260267 ENSG00000260304 ZNF764 BCL7C NPIPB13 ZNF747 PRR14 ZNF720 ENSG00000235560 CDIPT
GH16F031025 1.4 Ensembl ENCODE 47.9 -131.1 -131141 1.0 ZNF493 ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 ZNF302 ZNF143 ZNF548 ENSG00000260267 ZNF747 ZNF720 NPIPB13 ZNF764 ENSG00000260304 BCL7C ZNF785 ENSG00000261474 KAT8
GH16F030589 0.8 ENCODE 47.9 +304.5 304478 1.0 ZFP64 ZNF493 ZEB1 ZNF121 ZNF23 ZNF138 KLF7 ZNF548 ZNF202 ZNF362 ENSG00000260267 NPIPB13 ZNF764 SMG1P2 ZNF747 ENSG00000260304 BCL7C ENSG00000261474 ZNF785 ENSG00000235560
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BCL7C on UCSC Golden Path with GeneCards custom track

Promoters for BCL7C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001632994 1060 1401 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143
ENSR00001800941 -1840 1201 HDGF PKNOX1 ARID4B ETS1 YY1 GLIS2 ELK1 ZNF143 KDM4B KLF13

Genomic Location for BCL7C Gene

Chromosome:
16
Start:
30,833,626 bp from pter
End:
30,894,960 bp from pter
Size:
61,335 bases
Orientation:
Minus strand

Genomic View for BCL7C Gene

Genes around BCL7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL7C Gene

Proteins for BCL7C Gene

  • Protein details for BCL7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUZ0-BCL7C_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member C
    Protein Accession:
    Q8WUZ0
    Secondary Accessions:
    • O43770
    • Q6PD89

    Protein attributes for BCL7C Gene

    Size:
    217 amino acids
    Molecular mass:
    23468 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL7C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL7C Gene

Post-translational modifications for BCL7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCL7C Gene

Domains & Families for BCL7C Gene

Protein Domains for BCL7C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL7C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUZ0

UniProtKB/Swiss-Prot:

BCL7C_HUMAN :
  • Belongs to the BCL7 family.
Family:
  • Belongs to the BCL7 family.
genes like me logo Genes that share domains with BCL7C: view

No data available for Gene Families for BCL7C Gene

Function for BCL7C Gene

Molecular function for BCL7C Gene

GENATLAS Biochemistry:
putative F-actin cross-linking protein 12,homolog,BCL7A family
UniProtKB/Swiss-Prot Function:
May play an anti-apoptotic role.
genes like me logo Genes that share phenotypes with BCL7C: view

Animal Model Products

miRNA for BCL7C Gene

miRTarBase miRNAs that target BCL7C

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL7C Gene

Localization for BCL7C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL7C Gene COMPARTMENTS Subcellular localization image for BCL7C gene
Compartment Confidence
nucleus 4
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BCL7C Gene

Pathways & Interactions for BCL7C Gene

SuperPathways for BCL7C Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BCL7C: view

No data available for Pathways by source and SIGNOR curated interactions for BCL7C Gene

Transcripts for BCL7C Gene

Unigene Clusters for BCL7C Gene

B-cell CLL/lymphoma 7C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL7C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for BCL7C Gene

GeneLoc Exon Structure for
BCL7C
ECgene alternative splicing isoforms for
BCL7C

Expression for BCL7C Gene

mRNA expression in normal human tissues for BCL7C Gene

Protein differential expression in normal tissues from HIPED for BCL7C Gene

This gene is overexpressed in Nasal epithelium (33.9), Blymphocyte (10.2), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL7C Gene



Protein tissue co-expression partners for BCL7C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCL7C Gene:

BCL7C

SOURCE GeneReport for Unigene cluster for BCL7C Gene:

Hs.658547

mRNA Expression by UniProt/SwissProt for BCL7C Gene:

Q8WUZ0-BCL7C_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with BCL7C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCL7C Gene

Orthologs for BCL7C Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL7C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia BCL7C 34 35
  • 94.32 (n)
cow
(Bos Taurus)
Mammalia BCL7C 34 35
  • 92.17 (n)
chimpanzee
(Pan troglodytes)
Mammalia BCL7C 34 35
  • 92.01 (n)
mouse
(Mus musculus)
Mammalia Bcl7c 34 16 35
  • 90.32 (n)
rat
(Rattus norvegicus)
Mammalia Bcl7c 34
  • 90.17 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL7C 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL7C 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL7C 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158618 34
  • 58.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta BCL7-like 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C28H8.1 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for BCL7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for BCL7C Gene

ENSEMBL:
Gene Tree for BCL7C (if available)
TreeFam:
Gene Tree for BCL7C (if available)

Paralogs for BCL7C Gene

Paralogs for BCL7C Gene

(3) SIMAP similar genes for BCL7C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BCL7C: view

Variants for BCL7C Gene

Sequence variations from dbSNP and Humsavar for BCL7C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10431984 -- 30,877,622(+) tttta(A/G)tagag intron-variant
rs10431985 -- 30,877,625(+) tagta(A/G)agatg intron-variant
rs111305997 -- 30,849,761(+) TTTTC(-/T)TTTTT intron-variant
rs111337799 -- 30,866,913(+) GCTGA(A/G)CATGG intron-variant
rs11150596 -- 30,838,921(+) CAAAT(C/T)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL7C Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
esv28742 CNV loss 19812545
nsv1060384 CNV gain 25217958
nsv1113781 CNV deletion 24896259
nsv457483 CNV loss 19166990
nsv507813 OTHER sequence alteration 20534489
nsv571820 CNV loss 21841781
nsv833189 CNV loss 17160897
nsv953802 CNV deletion 24416366

Variation tolerance for BCL7C Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL7C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL7C Gene

Disorders for BCL7C Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCL7C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search BCL7C in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCL7C

Genetic Association Database (GAD)
BCL7C
Human Genome Epidemiology (HuGE) Navigator
BCL7C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL7C
genes like me logo Genes that share disorders with BCL7C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL7C Gene

Publications for BCL7C Gene

  1. The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel D.M. … Dyer M.J.S. (Gene 1998) 2 3 4 22 64
  2. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton L.M. … Hartge P. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 46 64
  3. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PMID: 19573080) Liang X.S. … Goldin L.R. (Br. J. Haematol. 2009) 3 46 64
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for BCL7C Gene

Sources for BCL7C Gene

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