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Aliases for BCL7C Gene

Aliases for BCL7C Gene

  • B-Cell CLL/Lymphoma 7C 2 3

External Ids for BCL7C Gene

Previous GeneCards Identifiers for BCL7C Gene

  • GC16P9B0085
  • GC16M031396
  • GC16M030896
  • GC16M030935
  • GC16M030806
  • GC16M030847

Summaries for BCL7C Gene

Entrez Gene Summary for BCL7C Gene

  • This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for BCL7C Gene

BCL7C (B-Cell CLL/Lymphoma 7C) is a Protein Coding gene. An important paralog of this gene is BCL7A.

UniProtKB/Swiss-Prot for BCL7C Gene

  • May play an anti-apoptotic role.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL7C Gene

Genomics for BCL7C Gene

Regulatory Elements for BCL7C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BCL7C Gene

30,833,626 bp from pter
30,894,960 bp from pter
61,335 bases
Minus strand

Genomic View for BCL7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL7C Gene

Proteins for BCL7C Gene

  • Protein details for BCL7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member C
    Protein Accession:
    Secondary Accessions:
    • O43770
    • Q6PD89

    Protein attributes for BCL7C Gene

    217 amino acids
    Molecular mass:
    23468 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL7C Gene


neXtProt entry for BCL7C Gene

Proteomics data for BCL7C Gene at MOPED

Post-translational modifications for BCL7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL7C Gene

No data available for DME Specific Peptides for BCL7C Gene

Domains & Families for BCL7C Gene

Protein Domains for BCL7C Gene


Suggested Antigen Peptide Sequences for BCL7C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BCL7 family.
  • Belongs to the BCL7 family.
genes like me logo Genes that share domains with BCL7C: view

No data available for Gene Families for BCL7C Gene

Function for BCL7C Gene

Molecular function for BCL7C Gene

GENATLAS Biochemistry:
putative F-actin cross-linking protein 12,homolog,BCL7A family
UniProtKB/Swiss-Prot Function:
May play an anti-apoptotic role.

Phenotypes for BCL7C Gene

GenomeRNAi human phenotypes for BCL7C:
genes like me logo Genes that share phenotypes with BCL7C: view

Animal Model Products

miRNA for BCL7C Gene

miRTarBase miRNAs that target BCL7C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL7C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL7C Gene

Localization for BCL7C Gene

Subcellular locations from

Jensen Localization Image for BCL7C Gene COMPARTMENTS Subcellular localization image for BCL7C gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BCL7C Gene

Pathways & Interactions for BCL7C Gene

SuperPathways for BCL7C Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BCL7C: view

No data available for Pathways by source and SIGNOR curated interactions for BCL7C Gene

Drugs & Compounds for BCL7C Gene

No Compound Related Data Available

Transcripts for BCL7C Gene

Unigene Clusters for BCL7C Gene

B-cell CLL/lymphoma 7C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL7C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL7C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -

Relevant External Links for BCL7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL7C Gene

mRNA expression in normal human tissues for BCL7C Gene

Protein differential expression in normal tissues from HIPED for BCL7C Gene

This gene is overexpressed in Nasal epithelium (33.9), Blymphocyte (10.2), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL7C Gene

SOURCE GeneReport for Unigene cluster for BCL7C Gene Hs.658547

mRNA Expression by UniProt/SwissProt for BCL7C Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with BCL7C: view

Protein tissue co-expression partners for BCL7C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCL7C Gene

Orthologs for BCL7C Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL7C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BCL7C 35
  • 92.17 (n)
  • 97.24 (a)
BCL7C 36
  • 84 (a)
(Canis familiaris)
Mammalia BCL7C 35
  • 94.32 (n)
  • 98.62 (a)
BCL7C 36
  • 74 (a)
(Mus musculus)
Mammalia Bcl7c 35
  • 90.32 (n)
  • 93.09 (a)
Bcl7c 16
Bcl7c 36
  • 93 (a)
(Pan troglodytes)
Mammalia BCL7C 35
  • 92.01 (n)
  • 90.32 (a)
BCL7C 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Bcl7c 35
  • 90.17 (n)
  • 94.01 (a)
(Monodelphis domestica)
Mammalia BCL7C 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia BCL7C 36
  • 81 (a)
(Anolis carolinensis)
Reptilia BCL7C 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158618 35
  • 58.59 (n)
  • 52.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta BCL7-like 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea C28H8.1 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for BCL7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for BCL7C Gene

Gene Tree for BCL7C (if available)
Gene Tree for BCL7C (if available)

Paralogs for BCL7C Gene

Paralogs for BCL7C Gene

(3) SIMAP similar genes for BCL7C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BCL7C: view

Variants for BCL7C Gene

Sequence variations from dbSNP and Humsavar for BCL7C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2125293 -- 30,852,554(+) tattg(C/T)gatct intron-variant
rs2168834 -- 30,852,526(+) ctgct(C/T)tggcg intron-variant
rs2335013 -- 30,866,025(+) CCACC(G/T)CGCCC intron-variant
rs2878304 -- 30,867,045(+) AGATA(C/T)CCTGT intron-variant
rs4046092 -- 30,865,891(+) CCTAA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL7C Gene

Variant ID Type Subtype PubMed ID
nsv905728 CNV Loss 21882294
nsv905729 CNV Loss 21882294
nsv905733 CNV Loss 21882294
nsv833189 CNV Loss 17160897
dgv35n68 CNV Loss 17160897
dgv2670n71 CNV Loss 21882294
dgv2671n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990

Variation tolerance for BCL7C Gene

Residual Variation Intolerance Score: 49.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL7C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL7C Gene

Disorders for BCL7C Gene

Relevant External Links for BCL7C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BCL7C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL7C Gene

Publications for BCL7C Gene

  1. The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel D.M. … Dyer M.J.S. (Gene 1998) 2 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PMID: 23275444) Steunou A.L. … Nieto L. (Mol. Cell Proteomics 2013) 67

Products for BCL7C Gene

Sources for BCL7C Gene

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