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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL7C Gene

protein-coding GIFtS: 49
GCID: GC16M030849

B-cell CLL/lymphoma 7C

Explore 5 diseases affiliated with
BCL7C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 7C¹ ²
B-Cell CLL/Lymphoma 7 Protein Family Member C²

External Ids:	HGNC: 1006¹	Entrez Gene: 9274²	Ensembl: ENSG00000099385⁷	OMIM: 605847⁵	UniProtKB: Q8WUZ0³

Export aliases for BCL7C gene to outside databases

Previous GC identifers: GC16P9B0085 GC16M031396 GC16M030896 GC16M030935 GC16M030806 GC16M030847

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL7C:

This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein

is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell

line. The function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BCL7C_HUMAN, Q8WUZ0

Function: May play an anti-apoptotic role (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL7C gene promoter:
STAT1 p53 STAT1beta CUTL1 NF-kappaB STAT1alpha STAT3 ARP-1 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BCL7C promoter sequence

Search SABiosciences Chromatin IP Primers for BCL7C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL7C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11

BCL7C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL7C gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M030849: view genomic region (about GC identifiers)

Start:	30,844,947 bp from pter	End:	30,906,281 bp from pter
Size:	61,335 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BCL7C_HUMAN, Q8WUZ0 (See protein sequence)

Recommended Name: B-cell CLL/lymphoma 7 protein family member C

Size: 217 amino acids; 23468 Da

Secondary accessions: O43770 Q6PD89

Alternative splicing: 2 isoforms: Q8WUZ0-1 Q8WUZ0-2

Explore the universe of human proteins at neXtProt for BCL7C: NX_Q8WUZ0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WUZ0

BCL7C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004756.2

ENSEMBL proteins:

ENSP00000369674 ENSP00000461177 ENSP00000459007 ENSP00000215115

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCL7C for domains About GeneDecksing

1 InterPro domain/family:

IPR006804 BCL7

Graphical View of Domain Structure for InterPro Entry Q8WUZ0

ProtoNet protein and cluster: Q8WUZ0

UniProtKB/Swiss-Prot: BCL7C_HUMAN, Q8WUZ0

Similarity: Belongs to the BCL7 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BCL7C_HUMAN, Q8WUZ0

Function: May play an anti-apoptotic role (By similarity)

Genatlas biochemistry entry for BCL7C:

putative F-actin cross-linking protein 12,homolog,BCL7A family

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BCL7C

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/564 Interacting proteins for BCL7C (Q8WUZ0^{2, 3} ENSP00000215115⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 564)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACTB	P60709²^,³, ENSP00000349960⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000349960
ARID1A	O14497²^,³, ENSP00000320485⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000320485
SMARCB1	Q12824²^,³, ENSP00000263121⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000263121
SMARCD1	Q96GM5²^,³, ENSP00000378414⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000378414
SMARCE1	Q969G3²^,³, ENSP00000323967⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000323967

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--

BCL7C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Browse Tocris compounds for BCL7C
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for BCL7C gene:

NM_004765.2

Unigene Cluster for BCL7C:

B-cell CLL/lymphoma 7C

Hs.658547 [show with all ESTs]

Unigene Representative Sequence: BC058863

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380317(uc021tgq.1) ENST00000574418 ENST00000576194 ENST00000572628

ENST00000215115(uc002dzv.3)

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Additional cDNA sequence:

AJ223980.1 BC019071.1 BC058863.1

6 DOTS entries:

DT.102621 DT.86850688 DT.446279 DT.91758025 DT.97814657 DT.91758026

24/88 AceView cDNA sequences (see all 88):

BQ186087 CK825699 CD518801 BU902606 BQ181046 BC010017 NM_004765 BQ420735

AW249720 AI377560 BG684506 BP429860 BC019071 AI146266 BU507579 BM793374

BM682538 BQ212740 BG760881 BQ189495 BI668566 CB243151 BU160225 BU850184

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL7C About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6
SP1:											-
SP2:

ECgene alternative splicing isoforms for BCL7C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL7C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGGCCGGA

About this image

BCL7C expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BCL7C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL7C

SOURCE GeneReport for Unigene cluster: Hs.658547

UniProtKB/Swiss-Prot: BCL7C_HUMAN, Q8WUZ0

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BCL7C gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	BCL7C⁶	--	51(a)	1 ↔ 1	GL343220.1(1720811-1728456)
fruit fly (Drosophila melanogaster)	Insecta	BCL7-like⁶	BCL7-like	30(a)	1 → many	X(9250667-9252627)
worm (Caenorhabditis elegans)	Secernentea	C28H8.1⁶	BCL7-like protein C28H8.1	29(a)	1 → many	III(5926015-5927121)

ENSEMBL Gene Tree for BCL7C (if available)
TreeFam Gene Tree for BCL7C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BCL7C gene

BCL7B² BCL7A²

3 SIMAP similar genes for BCL7C using alignment to 3 protein entries: BCL7C_HUMAN (see all proteins):

BCL7B SETMAR BCL7A

BCL7C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191800612^1,2		--	30899017(+)	`GTCCTC/GTCAGA`	1	--	ds500¹		0	--	--	--	--
rs184326078^1,2		--	30899020(+)	`CTCTCA/GGAGCC`	1	--	ds500¹		0	--	--	--	--
rs200463487^1,2		--	30899153(+)	`AGGGGC/TCCCTG`	1	--	ut3¹		0	--	--	--	--
rs112518198^1,2		--	30899393(+)	`GCCTCC/TACTCC`	1	--	int¹		1		CSA	2
rs75283978^1,2	C,	--	30899465(+)	`GGCACA/CAAAAA`	1	--	int¹		0	--	--	--	--
rs139294330^1,2		--	30899473(+)	`AAACAA/GCAACG`	1	--	int¹		0	--	--	--	--
rs78708752^1,2	C,F,	--	30899502(+)	`GGAACG/AAACCT`	1	--	int¹		1		WA	118
rs190156426^1,2		--	30899546(+)	`GCCTCA/GTGAGA`	1	--	int¹		0	--	--	--	--
rs181929520^1,2		--	30899848(+)	`AGACGC/GGGTTT`	1	--	int¹		0	--	--	--	--
rs113428907^1,2		--	30899946(+)	`CCACCG/ACGCCC`	1	--	int¹		1		CSA	2

HapMap Linkage Disequilibrium report for BCL7C (30844947 - 30906281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BCL7C
2 CNVs: 4942 4941

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BCL7C for disorders           About GeneDecksing

OMIM gene information: 605847    OMIM disorders: --

5 diseases for BCL7C:    About MalaCards

burkitt's lymphoma b-cell non-hodgkin lymphoma non-hodgkin lymphoma hodgkin's lymphoma

williams syndrome

Human Genome Epidemiology (HuGE) Navigator: BCL7C (3 documents)

Export disorders for BCL7C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BCL7C gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with BCL7C)

Utopia: connect your pdf to the dynamic
world of online information

The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PubMed id 9931421)^{1, 2, 3, 9} Jadayel D.M....Dyer M.J. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)¹ Rahman S....Howley P.M. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)¹ Golebiowski F....Hay R.T. (2009)
Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)¹ Hosgood H.D....Lan Q. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)¹ Liang X.S....Goldin L.R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9274	HGNC: 1006	AceView: BCL7C	Ensembl:ENSG00000099385	euGenes: HUgn9274
ECgene: BCL7C	H-InvDB: BCL7C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BCL7C	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BCL7C	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BCL7C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BCL7C gene:
Search GeneIP for patents involving BCL7C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCL7C
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	GenScript Custom Purified and Recombinant Proteins Services for BCL7C		GenScript cDNA clones with any tag delivered in your preferred vector for BCL7C
	GenScript Custom Assay Services for BCL7C		GenScript Custom Superior Antibodies Services for BCL7C
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	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL7C

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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BCL7C Gene

B-cell CLL/lymphoma 7C

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BCL7C Gene

B-cell CLL/lymphoma 7C

Aliasesfor BCL7C gene

Summariesfor BCL7C gene

Genomic Viewsfor BCL7C gene

Proteinsfor BCL7C gene

Protein Domains /Familiesfor BCL7C gene

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