External Ids for BCL7B Gene
Previous GeneCards Identifiers for BCL7B Gene
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for BCL7B Gene
BCL7B (BCL Tumor Suppressor 7B) is a Protein Coding gene. Diseases associated with BCL7B include Lymphoma and Atopic Dermatitis. GO annotations related to this gene include actin binding. An important paralog of this gene is BCL7C.
UniProtKB/Swiss-Prot for BCL7B Gene
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).