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Aliases for BCL7A Gene

Aliases for BCL7A Gene

  • B-Cell CLL/Lymphoma 7A 2 3
  • B-Cell CLL/Lymphoma-7 3
  • BCL7 3

External Ids for BCL7A Gene

Previous HGNC Symbols for BCL7A Gene

  • BCL7

Previous GeneCards Identifiers for BCL7A Gene

  • GC12M120913
  • GC12P121880
  • GC12P122228
  • GC12P120857
  • GC12P120921
  • GC12P122459
  • GC12P119470

Summaries for BCL7A Gene

Entrez Gene Summary for BCL7A Gene

  • This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL7A Gene

BCL7A (B-Cell CLL/Lymphoma 7A) is a Protein Coding gene. Diseases associated with BCL7A include hodgkin lymphoma and burkitt lymphoma. An important paralog of this gene is BCL7B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL7A Gene

Genomics for BCL7A Gene

Regulatory Elements for BCL7A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BCL7A Gene

122,019,422 bp from pter
122,062,044 bp from pter
42,623 bases
Plus strand

Genomic View for BCL7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for BCL7A Gene

Proteins for BCL7A Gene

  • Protein details for BCL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member A
    Protein Accession:
    Secondary Accessions:
    • B4DJN6
    • B7ZB21
    • Q13843
    • Q14CT7

    Protein attributes for BCL7A Gene

    210 amino acids
    Molecular mass:
    22810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL7A Gene


neXtProt entry for BCL7A Gene

Proteomics data for BCL7A Gene at MOPED

Post-translational modifications for BCL7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL7A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for BCL7A

No data available for DME Specific Peptides for BCL7A Gene

Domains & Families for BCL7A Gene

Protein Domains for BCL7A Gene


Suggested Antigen Peptide Sequences for BCL7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BCL7 family.
  • Belongs to the BCL7 family.
genes like me logo Genes that share domains with BCL7A: view

No data available for Gene Families for BCL7A Gene

Function for BCL7A Gene

Molecular function for BCL7A Gene

GENATLAS Biochemistry:
putative F-actin cross-linking protein 12,homolog to caldesmon,involved with MYC and IGH in a Burkitt lymphoma cell line with complex translocation t(9;14;12)(q24.1;q32.3;q24.1)

Gene Ontology (GO) - Molecular Function for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BCL7A: view
genes like me logo Genes that share phenotypes with BCL7A: view

Animal Model Products

miRNA for BCL7A Gene

miRTarBase miRNAs that target BCL7A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL7A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL7A Gene

Localization for BCL7A Gene

Gene Ontology (GO) - Cellular Components for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with BCL7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for BCL7A Gene

Pathways & Interactions for BCL7A Gene

SuperPathways for BCL7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated NAS 15897551
genes like me logo Genes that share ontologies with BCL7A: view

No data available for Pathways by source and SIGNOR curated interactions for BCL7A Gene

Drugs & Compounds for BCL7A Gene

No Compound Related Data Available

Transcripts for BCL7A Gene

mRNA/cDNA for BCL7A Gene

Unigene Clusters for BCL7A Gene

B-cell CLL/lymphoma 7A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL7A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL7A Gene

No ASD Table

Relevant External Links for BCL7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL7A Gene

mRNA expression in normal human tissues for BCL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCL7A Gene

This gene is overexpressed in Blymphocyte (45.8), Fetal gut (7.9), and Islet of Langerhans (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL7A Gene

SOURCE GeneReport for Unigene cluster for BCL7A Gene Hs.530970

genes like me logo Genes that share expression patterns with BCL7A: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BCL7A Gene

Orthologs for BCL7A Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL7A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BCL7A 35
  • 83.93 (n)
  • 85.14 (a)
BCL7A 36
  • 83 (a)
(Canis familiaris)
Mammalia BCL7A 35
  • 90.48 (n)
  • 92.64 (a)
BCL7A 36
  • 94 (a)
(Mus musculus)
Mammalia Bcl7a 35
  • 89.37 (n)
  • 94.29 (a)
Bcl7a 16
Bcl7a 36
  • 94 (a)
(Pan troglodytes)
Mammalia BCL7A 35
  • 99.57 (n)
  • 99.57 (a)
BCL7A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC690085 35
  • 89.35 (n)
  • 93.81 (a)
(Monodelphis domestica)
Mammalia BCL7A 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia BCL7A 36
  • 79 (a)
(Gallus gallus)
Aves BCL7A 35
  • 78.89 (n)
  • 84.76 (a)
gga-mir-762 36
  • 79 (a)
(Anolis carolinensis)
Reptilia BCL7A 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl7a 35
  • 66.83 (n)
  • 68.75 (a)
(Danio rerio)
Actinopterygii bcl7a 35
  • 69.4 (n)
  • 73.33 (a)
bcl7a 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta BCL7-like 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C28H8.1 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for BCL7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCL7A Gene

Gene Tree for BCL7A (if available)
Gene Tree for BCL7A (if available)

Paralogs for BCL7A Gene

Paralogs for BCL7A Gene

(2) SIMAP similar genes for BCL7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BCL7A: view

Variants for BCL7A Gene

Sequence variations from dbSNP and Humsavar for BCL7A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs884785 -- 122,035,242(+) AATAA(A/G)ATATT intron-variant
rs884786 -- 122,035,276(+) AGCAC(A/G)TGTGC intron-variant
rs1110123 -- 122,029,310(+) TGAGG(C/T)GTCTG intron-variant
rs1169091 -- 122,024,580(+) AGACT(C/T)AGCCC intron-variant
rs1169092 -- 122,025,996(+) cgggc(A/G)cgttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL7A Gene

Variant ID Type Subtype PubMed ID
esv2676551 CNV Deletion 23128226

Variation tolerance for BCL7A Gene

Residual Variation Intolerance Score: 33.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL7A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL7A Gene

Disorders for BCL7A Gene

MalaCards: The human disease database

(2) MalaCards diseases for BCL7A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
burkitt lymphoma
  • burkitt's lymphoma
- elite association
Search BCL7A in MalaCards View complete list of genes associated with diseases


  • Note=Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.

Relevant External Links for BCL7A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BCL7A: view

No data available for Genatlas for BCL7A Gene

Publications for BCL7A Gene

  1. The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel D.M. … Dyer M.J.S. (Gene 1998) 2 23 67
  2. Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (PMID: 8605326) Zani V.J. … Dyer M.J.S. (Blood 1996) 2 23 67
  3. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton L.M. … Hartge P. (Cancer Epidemiol. Biomarkers Prev. 2009) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for BCL7A Gene

Sources for BCL7A Gene

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