BCL7A Gene
protein-coding GIFtS: 52
GCID: GC12P122459
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B-cell CLL/lymphoma 7A
(Previous symbol: BCL7)
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Aliases
for BCL7A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| B-Cell CLL/Lymphoma 7A1 2 | | BCL71 2 5 | | B-Cell CLL/Lymphoma 7 Protein Family Member A2 | | B-Cell CLL/Lymphoma-72 |
Export aliases for BCL7A gene to outside databasesPrevious GC identifers: GC12M120913 GC12P121880 GC12P122228 GC12P120857 GC12P120921 GC12P119470 |
Summaries
for BCL7A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BCL7A:
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. Asa result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to berelated to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved inthe translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Twotranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
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Genomic Views
for BCL7A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BCL7A gene promoter:
Pax-5 MIF-1 E47 GATA-2 PPAR-alpha Pax-3 c-Myb FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BCL7A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL7A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.13 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.1BCL7A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P122459: view genomic region
(about GC identifiers)
Start:
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122,457,328 bp from pter |
End:
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122,499,950 bp from pter |
Size:
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42,623 bases |
Orientation:
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plus strand |
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Proteins
for BCL7A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BCL7A_HUMAN, Q4VC05 (See
protein sequence)Recommended Name: B-cell CLL/lymphoma 7 protein family member A Size: 210 amino acids; 22810 Da
Secondary accessions: B4DJN6 B7ZB21 Q13843 Q14CT7Alternative splicing: 2 isoforms: Q4VC05-1 Q4VC05-2 Explore the universe of human proteins at neXtProt for BCL7A: NX_Q4VC05
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4VC05
BCL7A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001019979.1 NP_066273.1
ENSEMBL proteins: ENSP00000445868 ENSP00000261822
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
BCL7A for ontologies About GeneDecksing
BCL7A Antibody Products:
Assay Products for BCL7A: |
Protein
Domains /
Families
for BCL7A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BCL7A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4VC05ProtoNet protein and cluster: Q4VC05 UniProtKB/Swiss-Prot: BCL7A_HUMAN, Q4VC05Similarity: Belongs to the BCL7 family |
Function
for BCL7A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for BCL7A:putative F-actin cross-linking protein 12,homolog to caldesmon,involved with MYC and IGH in a Burkitt lymphoma cellline with complex translocation t(9;14;12)(q24.1;q32.3;q24.1)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL7A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
BCL7A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BCL7A:
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Pathways & Interactions
for BCL7A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BCL7A
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for BCL7A (Q4VC052, 3 ENSP000002618224) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045892 | negative regulation of transcription, DNA-dependent |
NAS | 15897551 |
BCL7A for ontologies About GeneDecksing
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Drugs & Compounds
for BCL7A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BCL7A
Search CenterWatch for drugs/clinical trials and news about BCL7A
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Transcripts
for BCL7A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BCL7A gene (2 alternative transcripts): NM_001024808.1 NM_020993.3 Unigene Cluster for BCL7A: B-cell CLL/lymphoma 7A Hs.530970 [show with all ESTs]Unigene Representative Sequence: X899843 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000538010(uc001ubo.3 uc001ubp.3) ENST00000261822 ENST00000432926
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL7A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL7A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BCL7A (NM_020993) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCL7A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL7A |
Additional cDNA sequence: AK296159.1 AK316486.1 BC094723.1 BC113627.1 X89984.1 5 DOTS entries: DT.447256 DT.40263407 DT.100719098 DT.86852966 DT.86853243 24/140 AceView cDNA sequences (see all 140): AI684370 AA417616 BX390202 BQ216908 BE550028 AI380191 H79678 BE047975 BM665948 AI199447 BU509110 AW874477 AW295296 AW768827 BI916374 BM468560 BG056289 BM711997 Z41714 BQ930841 F02907 AI671188 AW592618 F02911
GeneLoc Exon Structure
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Expression
for BCL7A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BCL7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAATGTCT
About this image
See BCL7A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL7A
SOURCE GeneReport for Unigene cluster: Hs.530970
SABiosciences Custom PCR Arrays for BCL7A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL7A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCL7A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL7A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL7A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL7A |
Orthologs
for BCL7A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for BCL7A gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for BCL7A (if available)
TreeFam Gene Tree for BCL7A (if available) |
Paralogs
for BCL7A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BCL7A gene
- BCL7B2 BCL7C2
2 SIMAP similar genes for BCL7A using alignment to 1 protein entry: BCL7A_HUMAN:BCL7B BCL7C
BCL7A for paralogs About GeneDecksing
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Genomic Variants
for BCL7A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BCL7A (122457328 - 122499950 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BCL7A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL7A |
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Disorders
/ Diseases
for BCL7A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BCL7A for disorders About GeneDecksing
OMIM gene information: 601406
OMIM disorders: --
UniProtKB/Swiss-Prot: BCL7A_HUMAN, Q4VC05
Note=Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-waytranslocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions
10  diseases for BCL7A: About MalaCardsb-cell non-hodgkin lymphoma non-hodgkin lymphoma b-cell non-hodgkin lymphoma, high-grade hodgkin's lymphoma
burkitt's lymphoma supravalvular aortic stenosis mycosis fungoides juvenile astrocytoma
cutaneous t cell lymphoma williams syndrome
Human Genome Epidemiology (HuGE) Navigator: BCL7A (3 documents)
Export disorders for BCL7A gene to outside databases
|
Publications
for BCL7A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BCL7A gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with BCL7A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (PubMed id 8605326)1, 2, 3, 9 Zani V.J.... Dyer M.J.S. (1996)
- The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PubMed id 9931421)1, 3, 9 Jadayel D.M....Dyer M.J. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PubMed id 19336552)1, 9 Morton L.M....Hartge P. (2009)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
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External Searches for BCL7A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BCL7A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BCL7A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BCL7A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BCL7A gene:
Search GeneIP for patents involving BCL7A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BCL7A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for BCL7A | | OriGene Custom Protein Services for BCL7A | | | OriGene Custom Immunoassay Development | | |
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|  |  |  | | | | ThermoFisher Antibodies for BCL7A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL7A |
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