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Aliases for BCL7A Gene

Aliases for BCL7A Gene

  • B-Cell CLL/Lymphoma 7A 2 3
  • BCL7 3 6
  • B-Cell CLL/Lymphoma 7 Protein Family Member A 3
  • B-Cell CLL/Lymphoma-7 3

External Ids for BCL7A Gene

Previous Symbols for BCL7A Gene

  • BCL7

Summaries for BCL7A Gene

Entrez Gene Summary for BCL7A Gene

  • This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL7A Gene

BCL7A (B-Cell CLL/Lymphoma 7A) is a Protein Coding gene. Diseases associated with BCL7A include burkitt lymphoma and hodgkin lymphoma. An important paralog of this gene is BCL7B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL7A Gene

Genomics for BCL7A Gene

Genomic Location for BCL7A Gene

Start:
122,019,422 bp from pter
End:
122,062,044 bp from pter
Size:
42,623 bases
Orientation:
Plus strand

Genomic View for BCL7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL7A Gene

Regulatory Elements for BCL7A Gene

Proteins for BCL7A Gene

  • Protein details for BCL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC05-BCL7A_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member A
    Protein Accession:
    Q4VC05
    Secondary Accessions:
    • B4DJN6
    • B7ZB21
    • Q13843
    • Q14CT7

    Protein attributes for BCL7A Gene

    Size:
    210 amino acids
    Molecular mass:
    22810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL7A Gene

Proteomics data for BCL7A Gene at MOPED

Post-translational modifications for BCL7A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys27

Other Protein References for BCL7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL7A Gene

Domains for BCL7A Gene

Protein Domains for BCL7A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BCL7A_HUMAN
Family:
  • Belongs to the BCL7 family.:
    • Q4VC05
genes like me logo Genes that share domains with BCL7A: view

No data available for Gene Families for BCL7A Gene

Function for BCL7A Gene

Molecular function for BCL7A Gene

GENATLAS Biochemistry: putative F-actin cross-linking protein 12,homolog to caldesmon,involved with MYC and IGH in a Burkitt lymphoma cell line with complex translocation t(9;14;12)(q24.1;q32.3;q24.1)

Gene Ontology (GO) - Molecular Function for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BCL7A: view

Phenotypes for BCL7A Gene

GenomeRNAi human phenotypes for BCL7A:
genes like me logo Genes that share phenotypes with BCL7A: view

miRNA for BCL7A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BCL7A Gene

Localization for BCL7A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL7A Gene COMPARTMENTS Subcellular localization image for BCL7A gene
Compartment Confidence
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with BCL7A: view

Pathways for BCL7A Gene

SuperPathways for BCL7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated NAS 15897551
genes like me logo Genes that share ontologies with BCL7A: view

No data available for Pathways by source for BCL7A Gene

Transcripts for BCL7A Gene

mRNA/cDNA for BCL7A Gene

Unigene Clusters for BCL7A Gene

B-cell CLL/lymphoma 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL7A Gene

No ASD Table

Relevant External Links for BCL7A Gene

GeneLoc Exon Structure for
BCL7A
ECgene alternative splicing isoforms for
BCL7A

Expression for BCL7A Gene

mRNA expression in normal human tissues for BCL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL7A Gene

SOURCE GeneReport for Unigene cluster for BCL7A Gene Hs.530970

genes like me logo Genes that share expressions with BCL7A: view

Orthologs for BCL7A Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL7A 36
  • 99.57 (n)
  • 99.57 (a)
BCL7A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL7A 36
  • 83.93 (n)
  • 85.14 (a)
BCL7A 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL7A 36
  • 90.48 (n)
  • 92.64 (a)
BCL7A 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl7a 36
  • 89.37 (n)
  • 94.29 (a)
Bcl7a 16
Bcl7a 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL7A 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL7A 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC690085 36
  • 89.35 (n)
  • 93.81 (a)
chicken
(Gallus gallus)
Aves BCL7A 36
  • 78.89 (n)
  • 84.76 (a)
gga-mir-762 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL7A 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl7a 36
  • 66.83 (n)
  • 68.75 (a)
zebrafish
(Danio rerio)
Actinopterygii bcl7a 36
  • 69.4 (n)
  • 73.33 (a)
bcl7a 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BCL7-like 37
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C28H8.1 37
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for BCL7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCL7A Gene

ENSEMBL:
Gene Tree for BCL7A (if available)
TreeFam:
Gene Tree for BCL7A (if available)

Paralogs for BCL7A Gene

Paralogs for BCL7A Gene

Selected SIMAP similar genes for BCL7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BCL7A: view

Variants for BCL7A Gene

Sequence variations from dbSNP and Humsavar for BCL7A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs884785 -- 122,035,242(+) AATAA(A/G)ATATT intron-variant
rs884786 -- 122,035,276(+) AGCAC(A/G)TGTGC intron-variant
rs1110123 -- 122,029,310(+) TGAGG(C/T)GTCTG intron-variant
rs1169091 -- 122,024,580(+) AGACT(C/T)AGCCC intron-variant
rs1169092 -- 122,025,996(+) cgggc(A/G)cgttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL7A Gene

Variant ID Type Subtype PubMed ID
esv2676551 CNV Deletion 23128226

Relevant External Links for BCL7A Gene

HapMap Linkage Disequilibrium report
BCL7A

Disorders for BCL7A Gene

UniProtKB/Swiss-Prot

BCL7A_HUMAN
  • Note=Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.

Relevant External Links for BCL7A

Genetic Association Database (GAD)
BCL7A
Human Genome Epidemiology (HuGE) Navigator
BCL7A
genes like me logo Genes that share disorders with BCL7A: view

Publications for BCL7A Gene

  1. Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (PMID: 8605326) Zani V.J. … Dyer M.J.S. (Blood 1996) 2 3 4 23
  2. The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel D.M. … Dyer M.J.S. (Gene 1998) 2 3 23
  3. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton L.M. … Hartge P. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PMID: 19573080) Liang X.S. … Goldin L.R. (Br. J. Haematol. 2009) 3 49

Products for BCL7A Gene

Sources for BCL7A Gene

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