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Aliases for BCL6B Gene

Aliases for BCL6B Gene

  • B-Cell CLL/Lymphoma 6B 2 3 5
  • Zinc Finger Protein 62 2 3 4
  • B-Cell CLL/Lymphoma 6, Member B (Zinc Finger Protein) 2 3
  • Bcl6-Associated Zinc Finger Protein 3 4
  • ZNF62 3 4
  • BAZF 3 4
  • B-Cell CLL/Lymphoma 6 Member B Protein 3
  • B-Cell CLL/Lymphoma 6, Member B 2
  • ZBTB28 3

External Ids for BCL6B Gene

Previous HGNC Symbols for BCL6B Gene

  • ZNF62

Previous GeneCards Identifiers for BCL6B Gene

  • GC17U990185
  • GC17P006871
  • GC17P007126
  • GC17P006867
  • GC17P006926

Summaries for BCL6B Gene

GeneCards Summary for BCL6B Gene

BCL6B (B-Cell CLL/Lymphoma 6B) is a Protein Coding gene. Diseases associated with BCL6B include Lymphoma. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is BCL6.

UniProtKB/Swiss-Prot for BCL6B Gene

  • Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Wiki entry for BCL6B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL6B Gene

Genomics for BCL6B Gene

Regulatory Elements for BCL6B Gene

Enhancers for BCL6B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007130 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +109.2 109192 4.0 HDGF PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68 GABARAP SAT2
GH17G007010 1.8 FANTOM5 ENCODE dbSUPER 10.9 -5.3 -5307 13.7 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DVL2 NLGN2 ENSG00000262089 ZBTB4 SNORD10 NEURL4 CNTROB SNORA48 MIR497HG SENP3
GH17G007135 1.4 Ensembl ENCODE dbSUPER 10.9 +114.6 114625 4.3 AGO1 ARID4B YY1 ZNF121 GLIS2 ZNF143 ZNF207 SP5 REST TBX21 SLC16A11 RPL7AP64 ASGR2 BCL6B MIR324 CLEC10A KCNAB3 LOC105371512
GH17G006853 1.2 Ensembl ENCODE 10.5 -168.4 -168359 2.7 ELF3 ARID4B SIN3A DMAP1 THRB RAD21 ZBTB7B ZBTB40 RARA YY1 TEKT1 FBXO39 BCL6B SLC13A5 MIR195 ALOX12P2 GC17M006868
GH17G007171 1.2 Ensembl ENCODE 10.2 +150.7 150661 4.2 FOXA2 ZNF133 YBX1 GLI4 ZNF207 KLF7 ZNF548 PAF1 ZNF202 ZNF662 DVL2 NLGN2 NEURL4 SNORD10 ATP1B2 SNORA48 MIR324 ZBTB4 PER1 LOC100996842
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCL6B on UCSC Golden Path with GeneCards custom track

Promoters for BCL6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090786 680 201 ATF1 BACH1 RBBP5 E2F1 POLR2A CREM ZNF680 ZBTB2 NRF1 ZBTB11

Genomic Location for BCL6B Gene

Chromosome:
17
Start:
7,023,020 bp from pter
End:
7,030,290 bp from pter
Size:
7,271 bases
Orientation:
Plus strand

Genomic View for BCL6B Gene

Genes around BCL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL6B Gene

Proteins for BCL6B Gene

  • Protein details for BCL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N143-BCL6B_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 6 member B protein
    Protein Accession:
    Q8N143
    Secondary Accessions:
    • Q6PCB4

    Protein attributes for BCL6B Gene

    Size:
    479 amino acids
    Molecular mass:
    51531 Da
    Quaternary structure:
    • Associates with BCL6 through the BTB domain.

neXtProt entry for BCL6B Gene

Post-translational modifications for BCL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL6B Gene

No data available for DME Specific Peptides for BCL6B Gene

Domains & Families for BCL6B Gene

Gene Families for BCL6B Gene

Protein Domains for BCL6B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCL6B: view

No data available for UniProtKB/Swiss-Prot for BCL6B Gene

Function for BCL6B Gene

Molecular function for BCL6B Gene

UniProtKB/Swiss-Prot Function:
Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Ontology (GO) - Molecular Function for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with BCL6B: view
genes like me logo Genes that share phenotypes with BCL6B: view

Animal Models for BCL6B Gene

MGI Knock Outs for BCL6B:

Animal Model Products

CRISPR Products

miRNA for BCL6B Gene

miRTarBase miRNAs that target BCL6B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL6B Gene

Localization for BCL6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL6B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BCL6B: view

Pathways & Interactions for BCL6B Gene

SuperPathways for BCL6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0042092 type 2 immune response IBA --
GO:0042127 regulation of cell proliferation IBA --
GO:0050727 regulation of inflammatory response IBA --
genes like me logo Genes that share ontologies with BCL6B: view

No data available for Pathways by source and SIGNOR curated interactions for BCL6B Gene

Transcripts for BCL6B Gene

Unigene Clusters for BCL6B Gene

B-cell CLL/lymphoma 6, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for BCL6B Gene

GeneLoc Exon Structure for
BCL6B
ECgene alternative splicing isoforms for
BCL6B

Expression for BCL6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL6B Gene

This gene is overexpressed in Lung (x4.4).

Protein differential expression in normal tissues from HIPED for BCL6B Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCL6B Gene



Protein tissue co-expression partners for BCL6B Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL6B Gene:

BCL6B

SOURCE GeneReport for Unigene cluster for BCL6B Gene:

Hs.22575

mRNA Expression by UniProt/SwissProt for BCL6B Gene:

Q8N143-BCL6B_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression found in heart and placenta.
genes like me logo Genes that share expression patterns with BCL6B: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL6B Gene

Orthologs for BCL6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL6B 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia BCL6B 34 35
  • 89.36 (n)
dog
(Canis familiaris)
Mammalia BCL6B 34 35
  • 89.33 (n)
mouse
(Mus musculus)
Mammalia Bcl6b 34 16 35
  • 86.99 (n)
rat
(Rattus norvegicus)
Mammalia Bcl6b 34
  • 86.72 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL6B 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL6B 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BCL6B 35
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for BCL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL6B Gene

ENSEMBL:
Gene Tree for BCL6B (if available)
TreeFam:
Gene Tree for BCL6B (if available)

Paralogs for BCL6B Gene

Paralogs for BCL6B Gene

genes like me logo Genes that share paralogs with BCL6B: view

Variants for BCL6B Gene

Sequence variations from dbSNP and Humsavar for BCL6B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000145965 -- 7,024,003(+) TTTTT(C/T)AGGGG intron-variant
rs1000880100 -- 7,028,267(+) TAGGG(A/C)AGCTC utr-variant-3-prime
rs1000944195 -- 7,022,245(+) GGCGG(A/G)TGCCC upstream-variant-2KB
rs1000978265 -- 7,022,055(+) AGGTT(G/T)CAGCC upstream-variant-2KB
rs1001311702 -- 7,023,242(+) AATTC(C/T)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL6B Gene

Variant ID Type Subtype PubMed ID
esv1009485 CNV insertion 20482838
esv1378459 CNV insertion 17803354
esv2422288 CNV deletion 17116639
esv3302465 CNV tandem duplication 20981092
esv3302715 CNV tandem duplication 20981092
esv3362853 CNV insertion 20981092
esv3416608 CNV insertion 20981092
esv3451987 CNV insertion 20981092
esv987894 CNV insertion 20482838
nsv111719 CNV insertion 16902084
nsv112411 CNV insertion 16902084
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv827869 CNV gain 20364138
nsv952117 CNV deletion 24416366

Variation tolerance for BCL6B Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL6B Gene

Disorders for BCL6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCL6B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search BCL6B in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCL6B

Genetic Association Database (GAD)
BCL6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL6B
genes like me logo Genes that share disorders with BCL6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL6B Gene

Publications for BCL6B Gene

  1. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. (PMID: 9632807) Okabe S. … Tokuhisa T. (Mol. Cell. Biol. 1998) 2 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene. (PMID: 11855826) Sakashita C. … Miki T. (Biochem. Biophys. Res. Commun. 2002) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis. (PMID: 25970780) Wang W. … Zheng S. (Oncotarget 2015) 3 64

Products for BCL6B Gene

Sources for BCL6B Gene

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