Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BCL6B Gene

Aliases for BCL6B Gene

  • B-Cell CLL/Lymphoma 6, Member B 2 3
  • Zinc Finger Protein 62 2 3 4
  • BAZF 3 4 6
  • B-Cell CLL/Lymphoma 6, Member B (Zinc Finger Protein) 2 3
  • Bcl6-Associated Zinc Finger Protein 3 4
  • ZNF62 3 4
  • B-Cell CLL/Lymphoma 6 Member B Protein 3
  • ZBTB28 3

External Ids for BCL6B Gene

Previous HGNC Symbols for BCL6B Gene

  • ZNF62

Previous GeneCards Identifiers for BCL6B Gene

  • GC17U990185
  • GC17P006871
  • GC17P007126
  • GC17P006867
  • GC17P006926

Summaries for BCL6B Gene

GeneCards Summary for BCL6B Gene

BCL6B (B-Cell CLL/Lymphoma 6, Member B) is a Protein Coding gene. An important paralog of this gene is BCL6.

UniProtKB/Swiss-Prot for BCL6B Gene

  • Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Wiki entry for BCL6B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL6B Gene

Genomics for BCL6B Gene

Regulatory Elements for BCL6B Gene

Genomic Location for BCL6B Gene

Start:
7,023,020 bp from pter
End:
7,030,290 bp from pter
Size:
7,271 bases
Orientation:
Plus strand

Genomic View for BCL6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL6B Gene

Proteins for BCL6B Gene

  • Protein details for BCL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N143-BCL6B_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 6 member B protein
    Protein Accession:
    Q8N143
    Secondary Accessions:
    • Q6PCB4

    Protein attributes for BCL6B Gene

    Size:
    479 amino acids
    Molecular mass:
    51531 Da
    Quaternary structure:
    • Associates with BCL6 through the BTB domain.

neXtProt entry for BCL6B Gene

Proteomics data for BCL6B Gene at MOPED

Post-translational modifications for BCL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL6B Gene

No data available for DME Specific Peptides for BCL6B Gene

Domains for BCL6B Gene

Gene Families for BCL6B Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for BCL6B Gene

Graphical View of Domain Structure for InterPro Entry

Q8N143

UniProtKB/Swiss-Prot:

BCL6B_HUMAN :
  • Q8N143
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with BCL6B: view

Function for BCL6B Gene

Molecular function for BCL6B Gene

UniProtKB/Swiss-Prot Function: Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Ontology (GO) - Molecular Function for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with BCL6B: view
genes like me logo Genes that share phenotypes with BCL6B: view

Animal Models for BCL6B Gene

MGI Knock Outs for BCL6B:

miRNA for BCL6B Gene

miRTarBase miRNAs that target BCL6B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL6B Gene

Localization for BCL6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL6B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL6B Gene COMPARTMENTS Subcellular localization image for BCL6B gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BCL6B: view

Pathways for BCL6B Gene

SuperPathways for BCL6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with BCL6B: view

No data available for Pathways by source for BCL6B Gene

Transcripts for BCL6B Gene

Unigene Clusters for BCL6B Gene

B-cell CLL/lymphoma 6, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for BCL6B Gene

GeneLoc Exon Structure for
BCL6B
ECgene alternative splicing isoforms for
BCL6B

Expression for BCL6B Gene

mRNA expression in normal human tissues for BCL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL6B Gene

This gene is overexpressed in Lung (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BCL6B Gene

SOURCE GeneReport for Unigene cluster for BCL6B Gene Hs.22575

mRNA Expression by UniProt/SwissProt for BCL6B Gene

Q8N143-BCL6B_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression found in heart and placenta.
genes like me logo Genes that share expressions with BCL6B: view

Orthologs for BCL6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL6B 35
  • 99.65 (n)
  • 99.79 (a)
BCL6B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL6B 35
  • 89.36 (n)
  • 92.18 (a)
BCL6B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL6B 35
  • 89.33 (n)
  • 92.42 (a)
BCL6B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl6b 35
  • 86.99 (n)
  • 91.14 (a)
Bcl6b 16
Bcl6b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL6B 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL6B 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl6b 35
  • 86.72 (n)
  • 91.31 (a)
zebrafish
(Danio rerio)
Actinopterygii BCL6B 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for BCL6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL6B Gene

ENSEMBL:
Gene Tree for BCL6B (if available)
TreeFam:
Gene Tree for BCL6B (if available)

Paralogs for BCL6B Gene

Paralogs for BCL6B Gene

genes like me logo Genes that share paralogs with BCL6B: view

Variants for BCL6B Gene

Sequence variations from dbSNP and Humsavar for BCL6B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs312460 -- 7,022,811(+) TCCCT(A/C)ACCTC upstream-variant-2KB
rs312461 -- 7,024,031(-) AGACA(C/T)GCGCA intron-variant
rs393059 -- 7,025,072(-) GCCTA(C/G/T)GCAGA intron-variant
rs421264 -- 7,029,898(+) GAGGC(G/T)GCAGG downstream-variant-500B
rs525697 -- 7,024,129(-) CACGT(C/G)CACCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for BCL6B Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907634 CNV Loss 21882294
nsv457659 CNV Loss 19166990
esv269077 CNV Insertion 20981092
nsv827869 CNV Gain 20364138
esv259439 OTHER Complex 20981092
esv259689 OTHER Complex 20981092
esv987894 CNV Insertion 20482838
nsv111719 CNV Insertion 16902084
esv1009485 CNV Insertion 20482838
esv1378459 CNV Insertion 17803354
nsv112411 CNV Insertion 16902084

Relevant External Links for BCL6B Gene

HapMap Linkage Disequilibrium report
BCL6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL6B Gene

Disorders for BCL6B Gene

Relevant External Links for BCL6B

Genetic Association Database (GAD)
BCL6B
genes like me logo Genes that share disorders with BCL6B: view

No data available for UniProtKB/Swiss-Prot for BCL6B Gene

Publications for BCL6B Gene

  1. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. (PMID: 9632807) Okabe S. … Tokuhisa T. (Mol. Cell. Biol. 1998) 2 3 23
  2. Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene. (PMID: 11855826) Sakashita C. … Miki T. (Biochem. Biophys. Res. Commun. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival. (PMID: 21917650) Xu L. … Yu J. (Gut 2012) 3
  5. BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis. (PMID: 22279058) Ohnuki H. … Higashiyama S. (Blood 2012) 3

Products for BCL6B Gene

Sources for BCL6B Gene

Back to Top

Content