BCL6B Gene
protein-coding GIFtS : 49
GCID: GC17 P006926
B-cell CLL/lymphoma 6, member B (Previous names: zinc finger protein 62, B-cell CLL/lymphoma 6, member B... ) (Previous symbol: ZNF62 )
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Aliasesfor BCL6B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases B-Cell CLL/Lymphoma 6, Member B 1 2 ZBTB281 2 BAZF1 2 3 5 B-Cell CLL/Lymphoma 6, Member B (Zinc Finger Protein)1 2 Zinc Finger Protein 621 2 3 Bcl6-Associated Zinc Finger Protein2 3 ZNF621 2 3 B-Cell CLL/Lymphoma 6 Member B Protein2
Export aliases for BCL6B gene to outside databases Previous GC identifers: GC17U990185 GC17P006871 GC17P007126 GC17P006867
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Summariesfor BCL6B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: BCL6B_HUMAN, Q8N143 Function : Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrowstage or be related to some events in the early B-cell development Gene Wiki entry for BCL6B
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Genomic Viewsfor BCL6B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010718.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BCL6B gene promoter: E2F-4 E2F-3a E2F-5 Spz1 Nkx2-5 E2F-2 POU3F2 E2F E2F-1 Sox9 Other transcription factors Search SABiosciences Chromatin IP Primers for BCL6B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat BCL6B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1 BCL6B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P006926: view genomic region
(about GC identifiers )
Start:
6,926,339 bp from pter
End:
6,933,609 bp from pter
Size:
7,271 bases
Orientation:
plus strand
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Proteinsfor BCL6B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: BCL6B_HUMAN, Q8N143 (See
protein sequence )Recommended Name: B-cell CLL/lymphoma 6 member B protein Size : 479 amino acids; 51531 Da
Subunit : Associates with BCL6 through the BTB domain (By similarity)
Subcellular location : Nucleus (By similarity)
Secondary accessions : Q6PCB4Explore the universe of human proteins at neXtProt for BCL6B: NX_Q8N143 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N143 BCL6B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_862827.1 ENSEMBL proteins: ENSP00000293805 ENSP00000460071 ENSP00000460282 ENSP00000445010 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
BCL6B for ontologies About GeneDecksing BCL6B Antibody Products: Assay Products for BCL6B:
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Protein
Domains / Familiesfor BCL6B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
BCL6B for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q8N143 ProtoNet protein and cluster: Q8N143
1 Blocks protein family : IPB000210 BTB/POZ domain UniProtKB/Swiss-Prot: BCL6B_HUMAN, Q8N143 Similarity : Contains 1 BTB (POZ) domainSimilarity : Contains 5 C2H2-type zinc fingers
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Functionfor BCL6B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: BCL6B_HUMAN, Q8N143 Function : Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrowstage or be related to some events in the early B-cell development
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BCL6B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BCL6B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: BCL6B (NM_181844 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCL6B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BCL6B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL6B
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
BCL6B for ontologies About GeneDecksing 4 GenomeRNAi human phenotypes for BCL6B :Animal Models: Mouse knock-outs for BCL6B: Bcl6b tm2Dent Bcl6b tm1Dtf Bcl6b tm1Tto 4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Bcl6b) :
BCL6B for phenotypes About GeneDecksing
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Pathways & Interactionsfor BCL6B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL6B STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)5 Interacting proteins for BCL6B (Q8N143 3 ENSP00000293805 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
IEA --
BCL6B for ontologies About GeneDecksing
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Drugs & Compoundsfor BCL6B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for BCL6B Search CenterWatch for drugs/clinical trials and news about BCL6B
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Transcriptsfor BCL6B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for BCL6B gene: NM_181844.3 Unigene Cluster for BCL6B:
B-cell CLL/lymphoma 6, member B Hs.22575 [show with all ESTs ] Unigene Representative Sequence: BC059404 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000293805 (uc010clt.1 uc002geg.2 ) ENST00000572216 ENST00000576705 ENST00000573503 ENST00000537931 ENST00000571729 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BCL6B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BCL6B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: BCL6B (NM_181844 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCL6B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BCL6B
Additional cDNA sequence: AB076580.1 AK024695.1 AK122893.1 AK292878.1 AK293102.1 BC059404.1
5 DOTS entries : DT.75170305 DT.101982286
DT.407931 DT.95201154 DT.75107801 24/64 AceView cDNA sequences (see all 64 ):
NM_181844 N78611 BU741643 AI420964 BU102140 CA392306 H21615 AW271709 AI473457 AW451460 CB988714 BX281547 AK122893 AA703151 AI672318 CB990449 BF515380 AI932294 BM724372 BU101996 BU102174 AI004344 AB076580 BU102175 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL6B About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 SP1 :     -                           SP2 :                               SP3 :     -     -                       SP4 :                           -    
ECgene alternative splicing isoforms for BCL6B
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Expression for BCL6B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section BCL6B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATTTCTATTT
About this image BCL6B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See BCL6B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for BCL6B SOURCE GeneReport for Unigene cluster: Hs.22575 UniProtKB/Swiss-Prot: BCL6B_HUMAN, Q8N143 Tissue specificity : Ubiquitously expressed with higher expression found in heart and placenta SABiosciences Custom PCR Arrays for BCL6B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for BCL6BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat BCL6B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat BCL6B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat BCL6B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL6B
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Orthologsfor BCL6B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for BCL6B gene from 1/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
BX322601.36
--
36(a)
1 ↔ 1
7(21176760-21184134)
ENSEMBL Gene Tree for BCL6B (if available)TreeFam Gene Tree for BCL6B (if available)
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Paralogsfor BCL6B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for BCL6B gene BCL6 2 18/142 SIMAP similar genes for BCL6B using alignment to 5 protein entries: BCL6B_HUMAN (see all proteins )
(see all similar genes ):ZNF kr-znf3 ZNF626 ZNF285 ZNF56 HZF30 ZFS-6 ZNF253 ZNF83 ZBTB20 ZNF283 ZNF420 ZNF525 ZNF763 ZNF78L1 ZNF146 BACH1 DKFZp434J0650
BCL6B for paralogs About GeneDecksing
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Genomic Variantsfor BCL6B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for BCL6B (6926339 - 6933609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for BCL6B: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing BCL6B
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Disorders
/ Diseasesfor BCL6B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
BCL6B for disorders About GeneDecksing
OMIM gene information: 608992
OMIM disorders : --2 diseases for BCL6B : About MalaCards enamel erosion b-cell lymphomas Export disorders for BCL6B gene to outside databases
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Publicationsfor BCL6B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for BCL6B gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with BCL6B) Utopia : connect your pdf to the dynamic world of online information
BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. (PubMed id 9632807) 1 , 3, 9 Okabe S....Tokuhisa T. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene. (PubMed id 11855826) 1 , 2 Sakashita C.... Miki T. (2002) Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606) 1 Lin Y.Y....Boeke J.D. (2012) BAZF, a novel component of cullin3-based E3 ligase com plex, mediates VEGFR and Notch cross-signaling in angiogenesis. (PubMed id 22279058) 1 Ohnuki H....Higashiyama S. (2012) Epigenetic inactivation of BCL6B, a novel functional t umour suppressor for gastric cancer, is associated with poor survival. (PubMed id 21917650) 1 Xu L....Yu J. (2012) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196) 2 Zody M.C.... Nusbaum C. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Bcl6-dependent transcriptional repression by BAZF. (PubMed id 12659862) 1 Takenaga M....Tokuhisa T. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for BCL6B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing BCL6B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing BCL6B gene
(According to HUGE )
About This Section --
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Specialized Databases showing BCL6B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for BCL6B gene: Search GeneIP for patents involving BCL6B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor BCL6B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for BCL6B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for BCL6B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for BCL6B OriGene Protein Over-expression Lysate for BCL6B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for BCL6B OriGene 3'-UTR Clone for BCL6B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BCL6B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BCL6B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for BCL6B OriGene Custom Protein Services for BCL6B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCL6B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing BCL6B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat BCL6B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat BCL6B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat BCL6B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat BCL6B
Search Tocris compounds for BCL6B
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL6B
Search ThermoFisher Antibodies for BCL6B
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BCL6B
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Aliases for BCL6B
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