V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

BCL6 Gene

protein-coding GIFtS: 71

GC03M188921

B-cell CLL/lymphoma 6
(Previous name: zinc finger protein 51 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF51)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCL-5 ^³
BCL-6 ^³
BCL5 ^¹, ², ³
BCL6A ^¹, ²
LAZ3 ^¹, ², ³
ZBTB27 ^¹, ², ³
ZNF51 ^², ³

Descriptions
B-cell CLL/lymphoma 6 ^²
B-cell lymphoma 6 protein ^²
B-cell lymphoma 6 protein transcript ^²
LAZ-3 protein ^³
Zinc finger and BTB domain-containing protein 27 ^³
Zinc finger protein 51 ^¹, ², ³
cys-his2 zinc finger transcription factor ^²
lymphoma-associated zinc finger gene on chromosome 3 ^²
zinc finger transcription factor BCL6S ^²

External Ids
HGNC: 1001¹
Entrez Gene: 604²
UniProtKB: P41182³
Ensembl: ENSG00000113916⁷

Search outside databases for aliases for BCL6 gene

Previous GC identifers: GC03M184254 GC03M188700 GC03M188841 GC03M188760

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BCL6:

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal

POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been

shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can

interact with a variety of POZ-containing proteins that function as transcription corepressors.

This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma

(DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants

encoding different protein isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182

Function: Transcriptional repressor which is required for germinal center formation and antibody

affinity maturation. Probably plays an important role in lymphomagenesis

Gene Wiki entry for BCL6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BCL6 gene

Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27

BCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M188921: (about GC identifiers)

Start:	188,921,859 bp from pter
End:	188,946,169 bp from pter
Size:	24,311 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182 (See protein sequence)

Recommended Name: B-cell lymphoma 6 protein

Size: 706 amino acids; 78846 Da

Subunit: Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of

HDAC9

Subcellular location: Nucleus (By similarity)

PDB structures from and Proteopedia :

1R28 (3D)

1R29 (3D)

1R2B (3D)

2EN2 (3D)

2EOS (3D)

2YRM (3D)

3BIM (3D)

3E4U (3D)

Post-translational modifications:

Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its

degradation by ubiquitin/proteasome pathway¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001124317.1 NP_001128210.1 NP_001697.2 NP_620309.1

ENSEMBL proteins:

ENSP00000384371 ENSP00000232014

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bcl6, bcl-6)
	Human Recombinant Proteins from Abnova (BCL6)

OriGene Purified Recombinant Human Protein: BCL6

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	10898795
GO:0005657	colocalizes with replication fork	IDA	10490843

About this table

Antibodies for BCL6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BCL6
	Sigma-Aldrich Antibodies for BCL6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Bcl6, bcl-6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BCL6)
	Novus Biologicals Antibodies for BCL6

Assays for BCL6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P41182

ProtoNet protein and cluster: P41182

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 6 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCL6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001706

Applied Biosystems Silencer® siRNAs for BCL6

Sigma-Aldrich siRNA and siRNA Panels for BCL6

Sigma-Aldrich shRNA Panels and shRNA for BCL6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BCL6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001130845
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001130845
untagged cDNA clones in CMV expression vector (see all 4): NM_001130845

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001706

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182

Function: Transcriptional repressor which is required for germinal center formation and antibody

affinity maturation. Probably plays an important role in lymphomagenesis

Induction: Down-regulated during maturation of dendritic cells by selective stimuli such as LPS,

CD40L and zymosan

Genatlas biochemistry entry for BCL6:

breakpoint in B cell non Hodgkin lymphoma,in translocations t(3;14),t(2;3),t(3;22),t(3;4),t(3;11)

and others,same as LAZ3

11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Bcl6):

	cellular	growth/size	hematopoietic system	immune system
lethality-postnatal	life span-post-weaning/aging	liver/biliary system	muscle	reproductive system
respiratory system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IMP	15577913
GO:0005515	protein binding	IPI	10898795 16819511
GO:0008270	zinc ion binding	IEA	--
GO:0016564	transcription repressor activity	NAS	9135990
GO:0031490	chromatin DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for BCL6 (Your Favorite Gene powered by Ingenuity)

B Cell Receptor Signaling

GeneDecks BCL6 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BCL6

5/81 Interacting proteins for BCL6 (P41182^{1, 2} ENSP00000232014³) via UniProtKB, MINT, and/or STRING (see all 81 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HDAC4	P56524¹, ENSP00000264606³	EBI-765407, EBI-308629 STRING (score=.909)
HDAC9	Q9UKV0¹, ENSP00000262069³	EBI-765407, EBI-765444 STRING (score=.852)
ZMYND8	Q9ULU4¹	EBI-765407, EBI-765834
BCOR	ENSP00000367705³	STRING (score=.999)
IRF4	ENSP00000370343³	STRING (score=.999)

About this table

5/30 Gene Ontology (GO) biological process terms (links to tree view) (see all 30 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IGI	11821949
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	15577913
GO:0000902	cell morphogenesis	IEA	--
GO:0001953	negative regulation of cell-matrix adhesion	IEA	--
GO:0002634	regulation of germinal center formation	NAS	7795255

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BCL6
5 Novoseek chemical compound relationships for BCL6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
(h,g)-a-l	67.32	2	17296566 (1), 17038524 (1)
cytidine	56.58	4	16380510 (1), 16895557 (1), 15188366 (1), 12818155 (1)
zinc	52.56	52	11854457 (3), 9135990 (3), 10757802 (2), 11352661 (2) (see all 33)
bromodeoxyuridine	0.00	7	11046151 (3), 9921651 (1)
12-o-tetradecanoylphorbol 13-acetate	0.00	17	9180294 (5), 9188861 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCL6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001706

Sigma-Aldrich siRNA and siRNA Panels for BCL6

Sigma-Aldrich shRNA Panels and shRNA for BCL6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130845 NM_001134738 NM_001706

REFSEQ mRNAs for BCL6 gene (4 alternative transcripts):

NM_001130845.1 NM_001134738.1 NM_001706.3 NM_138931.1

NM_001130845 NM_001134738 NM_001706

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001130845
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001130845
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001130845

Additional cDNA sequence:

AK090890.1 AK304325.1 AK308162.1 AL713713.1 AL832990.1 BC142705.1 BC146796.1 BC150184.1

EU139066.1 EU883531.1 U00115.1 Z21943.1

16 DOTS entries:

DT.99956826 DT.99978801 DT.212094 DT.454834 DT.443706 DT.91757283 DT.100817094 DT.120907804

DT.120907845 DT.100662547 DT.100662593 DT.100735246 DT.120907853 DT.87016782 DT.95238239 DT.95345389

24/195 AceView cDNA sequences (see all 195 ):

AW629110 AA281781 CA405856 AW074564 CA405981 W95808 NM_138931 AA447608

BX419860 AW665543 BQ716058 T27711 AW576580 AA749422 BM454297 W79813

AI362271 AA371071 BQ722826 W95815 BM801045 AI362233 BU428597 AA448107

highest scoring ESTs for BCL6:

U00115 AA324061 AL534712 AU077329 AU279518 AW408149 BF959882 BI596814 BI599247 BI600342

Unigene Cluster for BCL6:

B-cell CLL/lymphoma 6

Hs.478588 [show with all ESTs]

Unigene Representative Sequence: NM_001130845

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL6

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:							-
SP2:							-				-
SP3:																					-
SP4:

About this scheme

ECgene alternative splicing isoforms for BCL6

2 Ensembl transcripts including schematic representations:

ENST00000406870 ENST00000232014

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BCL6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCL6

¹ / ² / ³

7 probe-sets matching BCL6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40091_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U00115	1.00	1.00	1.00	1
979_g_at²^{, 3}	U95-A	1	1.00	1.00	-0.19	0.11	Z79581	0.20	1.00	0.72	1
978_at*²^{, 3}	U95-A	1	--	--	0.01	0.15	Z79581	0.20	1.00	0.72	1
215990_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S67779	0.40	1.00	0.76	1
203140_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_001706	0.60	1.00	0.82	1
215990_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203140_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTGTGTTAT

SOURCE GeneReport for Unigene cluster: Hs.478588
Expression variation in blood from EXPOLDB for BCL6
UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
Tissue specificity: Expressed in germinal center T and B cells and in primary immature dendritic
cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BCL6 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCL6¹	--	B-cell CLL/lymphoma 6	92.59(n) 96.32(a)	488124 XM_545248.2 XP_545248.2
chimpanzee (Pan troglodytes)	BCL6¹	--	B-cell CLL/lymphoma 6	99.48(n) 99.72(a)	460926 XM_001158812.1 XP_001158812.1
cow (Bos taurus)	BCL6¹	--	B-cell CLL/lymphoma 6	91.41(n) 95.18(a)	539020 XM_584289.3 XP_584289.1
rat (Rattus norvegicus)	Bcl6¹	--	B-cell CLL/lymphoma 6	89.33(n) 95.18(a)	303836 XM_221333.4 XP_221333.1
mouse (Mus musculus)	Bcl6^{1, 5}	16 (13.90 cM)⁵	B-cell leukemia/lymphoma 6^{1, 5}	89.19(n)¹ 94.76(a)¹	12053¹ NM_009744.3¹ NP_033874.1¹ AK036975⁵ AK039228⁵ (see all 11)

About this table Species with no ortholog for BCL6

ENSEMBL Gene Tree for BCL6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BCL6 gene

BCL6B² ZBTB8A² ENSG00000215897²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/97 NCBI SNPs in BCL6 are shown (see all 97 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 83)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1523469^1,2	C,F	188946380(-)	`AGTTTA/C/GTGGGT`	1	--	ng3¹		3	MN EA	540
	rs954655^1,2	H	188947353(+)	`ACAGTC/TTTCTT`	1	--	ng3¹		4	EU EA WA	418
--	rs16862537^1,2	F	188946666(-)	`AAAATA/GCAGAA`	1	--	ng3¹ tfbs³		2	MN EA	356
	rs2378319^1,2	H	188947754(+)	`AATTCT/GTAAAG`	1	--	ng3¹ tfbs³		4	EU EA WA	418
	rs1523474^1,2	A,C,F,H,O	188942191(-)	`TGTGAA/GTCAAC`	1	--	int¹		20	EA NA MN EU WA	3042
	rs3821817^1,2	A,C,F,H	188939598(-)	`AGGAGG/CGGGGA`	1	--	int¹ trp³		2	EU WA	240
	rs4686467^1,2	A,C,F,H	188944990(+)	`CTCTCG/ATTAGG`	1	--	int¹		6	EU WA EA NA	454
	rs3774304^1,2	A,C,F,H	188937425(-)	`CACCCC/GGAGCC`	1	--	int¹		4	EU EA WA	416
	rs3172469^1,2	A,C,F,H	188941782(-)	`AGTACA/CTAAAG`	1	--	int¹		15	EA MN NA EU WA CSAM	2510
	rs3774303^1,2	A,C,F,H	188940815(-)	`GCCTGG/CACCAA`	1	--	int¹		12	EU EA WA NA	1202

About this table

HapMap Linkage Disequilibrium images for BCL6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109565

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182

Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma.

Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions

A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia.

Translocation t(3;11)(q27;q23) with POU2AF1/OBF1

A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation

t(3;4)(q27;p11) with ARHH/TTF

10/58 Novoseek disease relationships for BCL6 gene (see all 58 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma b-cell	93.60	199	18925696 (5), 9283593 (4), 7742550 (3), 10843287 (3) (see all 99)
lymphoma follicular	90.60	75	18925696 (5), 18500267 (3), 14674895 (3), 10208461 (2) (see all 51)
lymphoma large cell diffuse	88.83	34	7639334 (3), 9648553 (2), 15998973 (2), 7895484 (1) (see all 25)
lymphoma	85.92	224	15375218 (5), 12399978 (5), 10626250 (4), 9044511 (3) (see all 99)
lymphoma non-hodgkins	81.37	87	7742550 (2), 10953971 (2), 16125304 (2), 7472775 (2) (see all 61)
ofcd syndrome	76.07	2	17517692 (1), 15770227 (1)
malt lymphoma	73.59	43	15153535 (4), 17122510 (3), 11120333 (3), 18166802 (3) (see all 15)
burkitt lymphoma	72.67	18	16772123 (3), 9359519 (3), 16618762 (2), 12191569 (1) (see all 11)
lymphoid neoplasm	72.08	3	9373196 (1), 8703825 (1), 9209377 (1)
lymphoma large cell	68.47	6	11840294 (1), 8703825 (1), 10396291 (1), 9209377 (1) (see all 6)

About this table

1 PharmGKB disease relationship for BCL6 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Genatlas disease: BCL6

B-cell,diffuse large-cell lymphoma,follicular lymphoma and mantel cell lymphoma,mucosa-associated

lymphoid tissue non Hodgkin lymphoma with translocations

t(3;14)(q27;q32),t(3;13)(q27;q14),t(2;3)(p12;q27),t(3;22)(q27;q11),t(3;4)(q27;p11),t(3;11)(q27;q23),t(3;6)(q27;p21.3),also

rearranged in some marginal zone B-cell lymphoma,mutated in human herpes-8 positive primary

effusion lymphoma (PEL)

Genetic Association Database: BCL6
Human Genome Epidemiology Navigator: BCL6 (10 documents)
Tumor Gene Database: BCL6

(Possibly Related Articles in Doctor's Guide)
About This Section

Study Shows Promising Results Treating Blood-Borne and Bone Marrow Diseases: Presented at ASH

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/521 PubMed articles for BCL6 gene (see all 521 ):

A polymorphism in the BCL-6 gene is associated with follicle center lymphoma. (PubMed id 11911418)^{1, 3, 6} Lossos I.S....Levy R. (2001)
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large- cell lymphoma. (PubMed id 8235596)^{1, 3, 4} Ye B.H.... Dalla-Favera R. (1993)
Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma. (PubMed id 16125304)^{1, 3, 6} Susova S....Soucek P. (2006)
Clinical and biological relevance of single-nucleotide polymorphisms and acquired somatic mutations of the BCL6 first intron in follicular lymphoma. (PubMed id 16094416)^{1, 3, 6} Jardin F....Bastard C. (2005)
Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. (PubMed id 9649500)^{1, 3, 4} Niu H.... Dalla-Favera R. (1998)
Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein. (PubMed id 8274740)^{1, 3, 4} Miki T.... Aoki N. (1994)
Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. (PubMed id 16455075)^{3, 4} Pantano S.... Natoli G. (2006)
The histone deacetylase 9 gene encodes multiple protein isoforms. (PubMed id 12590135)^{3, 4} Petrie K....Zelent A. (2003)
Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. (PubMed id 8506375)^{3, 4} Baron B.W....McKeithan T.W. (1993)
LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. (PubMed id 8220427)^{3, 4} Kerckaert J.-P....Bastard C. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 604	HGNC: 1001	AceView: BCL6	Ensembl:ENSG00000113916	euGenes: HUgn604
ECgene: BCL6	H-InvDB: BCL6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BCL6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BCL6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BCL6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BCL6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BCL6		Antibodies for BCL6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BCL6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BCL6)
	Antibodies (BCL6)
	Chimera RNAi (BCL6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Bcl6, bcl-6)
	Antibodies (Bcl6, bcl-6)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for BCL6

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BCL6

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BCL6 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

BCL6 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for BCL6

Summaries
for BCL6

Genomic Location
for BCL6

Proteins
for BCL6

Protein Domains/
Families
for BCL6

Gene Function
for BCL6

Pathways & Interactions
for BCL6

Drugs & Compounds
for BCL6

Transcripts
for BCL6

Expression
for BCL6

Orthologs
for BCL6

Paralogs
for BCL6

SNPs/Variants
for BCL6

Disorders & Mutations
for BCL6

Medical News
for BCL6

Publications
for BCL6

Search for BCL6

Genome Databases showing BCL6

Other Databases showing BCL6

Specialized Databases showing BCL6

Licensable Technologies
for BCL6

Services
for BCL6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BCL6 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor BCL6

Summariesfor BCL6

Genomic Locationfor BCL6

Proteinsfor BCL6

Protein Domains/Familiesfor BCL6

Gene Functionfor BCL6

Pathways & Interactionsfor BCL6

Drugs & Compoundsfor BCL6

Transcriptsfor BCL6

Expression for BCL6

Orthologsfor BCL6

Paralogsfor BCL6

SNPs/Variantsfor BCL6

Disorders & Mutationsfor BCL6

Medical Newsfor BCL6

Publicationsfor BCL6

Search for BCL6

Genome Databases showing BCL6

Other Databases showing BCL6

Specialized Databases showing BCL6

Licensable Technologiesfor BCL6

Servicesfor BCL6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BCL6

Summaries
for BCL6

Genomic Location
for BCL6

Proteins
for BCL6

Protein Domains/
Families
for BCL6

Gene Function
for BCL6

Pathways & Interactions
for BCL6

Drugs & Compounds
for BCL6

Transcripts
for BCL6

Expression
for BCL6

Orthologs
for BCL6

Paralogs
for BCL6

SNPs/Variants
for BCL6

Disorders & Mutations
for BCL6

Medical News
for BCL6

Publications
for BCL6

Licensable Technologies
for BCL6

Services
for BCL6