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BCL6 Gene

protein-coding   GIFtS: 67
GCID: GC03M187439

B-Cell CLL/Lymphoma 6

(Previous name: zinc finger protein 51)
(Previous symbol: ZNF51)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B-Cell CLL/Lymphoma 61 2     ZBTB272 3
Zinc Finger Protein 511 2 3     B-Cell Lymphoma 5 Protein2 3
ZNF511 2 3     BCL6A2
Protein LAZ-32 3     B-Cell Lymphoma 6 Protein2
Zinc Finger And BTB Domain-Containing Protein 272 3     B-Cell Lymphoma 6 Protein Transcript2
BCL-52 3     Cys-His2 Zinc Finger Transcription Factor2
BCL-62 3     Lymphoma-Associated Zinc Finger Gene On Chromosome 32
BCL52 3     Zinc Finger Transcription Factor BCL6S2
LAZ32 3     

External Ids:    HGNC: 10011   Entrez Gene: 6042   Ensembl: ENSG000001139167   OMIM: 1095655   UniProtKB: P411823   

Export aliases for BCL6 gene to outside databases

Previous GC identifers: GC03M184254 GC03M188700 GC03M188841 GC03M188760 GC03M188921 GC03M184843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCL6 Gene:
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This
protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription
of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins
that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in
diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced
transcript variants encoding different protein isoforms have been found for this gene. (provided by RefSeq, Sep
2008)

GeneCards Summary for BCL6 Gene:
BCL6 (B-cell CLL/lymphoma 6) is a protein-coding gene. Diseases associated with BCL6 include primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma, and primary bone lymphoma. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BCL6B.

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
Function: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity
maturation which has different mechanisms of action specific to the lineage and biological functions. Forms
complexes with different corepressors and histone deacetylases to repress the transcriptional expression of
different subsets of target genes. Represses its target genes by binding directly to the DNA sequence
5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription
factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle
control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some
genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An
important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens
and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic
hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells
(T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2
and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and
B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on
certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC
B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the
alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as
HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to
neuronal differentiation

Gene Wiki entry for BCL6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCL6 gene promoter:
         AP-1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL6 promoter sequence
   Search Chromatin IP Primers for BCL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27

BCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M187439:  view genomic region     (about GC identifiers)

Start:
187,439,165 bp from pter      End:
187,463,515 bp from pter
Size:
24,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182 (See protein sequence)
Recommended Name: B-cell lymphoma 6 protein  
Size: 706 amino acids; 78846 Da
Subunit: Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions
are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer
elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone
deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with
SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts
(when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress.
Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its
transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective
NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4,
HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6
transpriptional repression
Selected PDB 3D structures from and Proteopedia for BCL6 (see all 10):
1R28 (3D)        1R29 (3D)        1R2B (3D)        2EN2 (3D)        2EOS (3D)        2LCE (3D)    
Secondary accessions: A7E241 B8PSA7 D3DNV5
Alternative splicing: 2 isoforms:  P41182-1   P41182-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCL6: NX_P41182

Explore proteomics data for BCL6 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM
    in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway1
  • Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome1
  • Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor
    function. Deacetylated by HDAC- and SIR2-dependent pathways1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BCL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124317.1  NP_001128210.1  NP_001697.2  

    ENSEMBL proteins: 
     ENSP00000384371   ENSP00000398014   ENSP00000232014   ENSP00000413122   ENSP00000415574  
     ENSP00000414455  

    BCL6 Human Recombinant Protein Products:

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    Novus Biologicals BCL6 Lysate
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    Browse Sino Biological Cell Lysates
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    BCL6 Antibody Products:

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    R&D Systems Antibodies for BCL6 (Bcl-6)
    Cell Signaling Technology (CST) Antibodies for BCL6  (Bcl-6)
    OriGene Antibodies for BCL6
    OriGene Custom Antibody Services for BCL6
    Novus Biologicals BCL6 Antibodies
    Search for Antibodies for BCL6 at Abcam
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    BCL6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCL6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry P41182

    ProtoNet protein and cluster: P41182

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
    Domain: The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to
    corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to
    facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and
    BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity)
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 C2H2-type zinc fingers


    BCL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL6_HUMAN, P41182
    Function: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity
    maturation which has different mechanisms of action specific to the lineage and biological functions. Forms
    complexes with different corepressors and histone deacetylases to repress the transcriptional expression of
    different subsets of target genes. Represses its target genes by binding directly to the DNA sequence
    5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription
    factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle
    control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some
    genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An
    important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens
    and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic
    hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells
    (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2
    and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and
    B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on
    certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC
    B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the
    alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as
    HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to
    neuronal differentiation
    Induction: Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial
    lipopolysaccharides (LPS), CD40LG and zymosan. Protein levels decreases upon genotoxic stress in a dose- and
    time-dependent way

         Genatlas biochemistry entry for BCL6:
    breakpoint in B cell non Hodgkin lymphoma,in translocations t(3;14),t(2;3),t(3;22),t(3;4),t(3;11) and others,same
    as LAZ3

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IDA12097386
    GO:0003700sequence-specific DNA binding transcription factor activity IMP15577913
    GO:0005515protein binding IPI10898795
    GO:0031490chromatin DNA binding IEA--
         
    BCL6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BCL6:
     Increased cell death HMECs cel  Increased homologous recombina  Synthetic lethal with c-Myc af 

         13 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Bcl6):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  no phenotypic analysis 
     normal  reproductive system  respiratory system 

    BCL6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BCL6: Bcl6tm1Sdt Bcl6tm1Rdf Bcl6tm1Tto Bcl6tm2Rdf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCL6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL6

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NNNCTTTCCAGGAAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCL6:
    hsa-mir-30b-5p (MIRT006324), hsa-mir-127-3p (MIRT004463), hsa-mir-335-5p (MIRT017492), hsa-mir-21-5p (MIRT035524), hsa-mir-339-5p (MIRT005929), hsa-mir-155-5p (MIRT006927), hsa-mir-9-5p (MIRT000640), hsa-mir-124-3p (MIRT022507)

    Block miRNA regulation of human, mouse, rat BCL6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL6 (see all 49):
    hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-30d hsa-miR-632 hsa-miR-346 hsa-miR-519a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidBCL6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BCL6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): BCL6 (NM_001130845)
    Sino Biological Human cDNA Clone for BCL6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BCL6_HUMAN, P41182: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10898795
    GO:0005657colocalizes with replication fork IDA10490843

    BCL6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCL6 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    2Wnt Signaling Pathway (WikiPathways)
    DNA damage response (only ATM dependent)0.32
    3Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    4Signaling events mediated by HDAC Class II
    Signaling events mediated by HDAC Class II
    5Selected targets of p53
    Selected targets of p53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BCL6
        Notch Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for BCL6
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for BCL6
        Immune response BCR pathway

    Selected BioSystems Pathways for BCL6 (see all 6)
        DNA damage response (only ATM dependent)
    B Cell Receptor Signaling Pathway
    IL4-mediated signaling events
    Direct p53 effectors
    Signaling events mediated by HDAC Class II



    2 Kegg Pathways  (Kegg details for BCL6):
        FoxO signaling pathway
    Transcriptional misregulation in cancer


    BCL6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL6 (see all 6): 
              Th1/Th2 Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCL6 (P411821, 2, 3 ENSP000002320144) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565241, 3, ENSP000002646064EBI-765407,EBI-308629 I2D: score=3 STRING: ENSP00000264606
    ENSG00000272333Q9UMN63, ENSP000002222704I2D: score=3 STRING: ENSP00000222270
    HDAC9Q9UKV01, 3, ENSP000004086174EBI-765407,EBI-765444 I2D: score=3 STRING: ENSP00000408617
    ZMYND8Q9ULU41, 3, ENSP000004182104EBI-765407,EBI-765834 I2D: score=3 STRING: ENSP00000418210
    PPARDQ031813, ENSP000003109284I2D: score=4 STRING: ENSP00000310928
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IGI11821949
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11929873
    GO:0000902cell morphogenesis IEA--
    GO:0001953negative regulation of cell-matrix adhesion IEA--
    GO:0002467germinal center formation IEA--

    BCL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCL6

    Selected Novoseek inferred chemical compound relationships for BCL6 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (h,g)-a-l 73.3 3 17296566 (1), 17038524 (1), 19234720 (1)
    cytidine 56.1 4 16380510 (1), 16895557 (1), 15188366 (1), 12818155 (1)
    zinc 51.3 57 11854457 (3), 9135990 (3), 10757802 (2), 20175752 (2) (see all 35)
    rituximab 35.6 8 19797725 (3), 19786664 (1), 16449523 (1)
    paraffin 33.4 12 10843287 (2), 15723651 (1), 9209651 (1), 10208461 (1) (see all 9)
    vincristine 32.1 2 19786664 (1), 16449523 (1)
    cyclophosphamide 18.8 2 19786664 (1), 16449523 (1)
    doxorubicin 9.46 2 19786664 (1), 16449523 (1)
    estrogen 5.29 5 19824433 (1), 12165517 (1)
    serine 3.76 2 12881702 (1), 9188861 (1)



    BCL6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BCL6 gene (4 alternative transcripts): 
    NM_001130845.1  NM_001134738.1  NM_001706.4  NM_138931.1  

    Unigene Cluster for BCL6:

    B-cell CLL/lymphoma 6
    Hs.478588  [show with all ESTs]
    Unigene Representative Sequence: NM_001130845
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406870(uc011bsf.1 uc003frq.2) ENST00000419510(uc003frp.3 uc010hza.2)
    ENST00000232014 ENST00000450123 ENST00000479110 ENST00000430339 ENST00000480458
    ENST00000438077 ENST00000470319 ENST00000496823
    miRNA
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    hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-30d hsa-miR-632 hsa-miR-346 hsa-miR-519a hsa-miR-374c
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    Additional mRNA sequence: 

    AK090890.1 AK304325.1 AK308162.1 AL713713.1 AL832990.1 BC142705.1 BC146796.1 BC150184.1 
    EU139066.1 EU883531.1 U00115.1 Z21943.1 

    15 DOTS entries:

    DT.99956826  DT.99978801  DT.454834  DT.212094  DT.91757283  DT.100817094  DT.120907804  DT.120907845 
    DT.443706  DT.100662547  DT.100662593  DT.100735246  DT.87016782  DT.95345389  DT.120907853 

    Selected AceView cDNA sequences (see all 195):

    AI080223 AW665543 AW302390 AW074564 AA749422 W79813 BQ230532 S67779 
    AA448107 BU428597 AU279518 CA405856 NM_001706 AA447608 AL603333 AA281781 
    AI362233 BM454297 AI090269 BQ716058 AI362271 AA371071 AI659577 W95815 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL6    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -                                                                     
    SP2:                    -           -                                                         
    SP3:                                                              -                           
    SP4:                                                                                          


    ECgene alternative splicing isoforms for BCL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BCL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTGTTAT
    BCL6 Expression
    About this image


    BCL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    BCL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.478588

    UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
    Tissue specificity: Expressed in germinal center T- and B-cells and in primary immature dendritic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL6 (see all 6): 
              Th1/Th2 Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BCL6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl61 , 5 B cell leukemia/lymphoma 61, 5 89.19(n)1
    94.76(a)1
      16 (15.26 cM)5
    120531  NM_009744.31  NP_033874.11 
     239650525 
    chicken
    (Gallus gallus)
    Aves BCL61 B-cell CLL/lymphoma 6 77.05(n)
    79.8(a)
      424912  NM_001012930.1  NP_001012948.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL66
    B-cell CLL/lymphoma 6
    76(a)
    1 ↔ 1
    GL343905.1(115608-137758)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bcl61 B-cell CLL/lymphoma 6 68.21(n)
    68.93(a)
      100126063  NM_001122806.1  NP_001116278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731622 B-cell lymphoma 6 protein 76.5(n)   393707  BC059515.1 


    ENSEMBL Gene Tree for BCL6 (if available)
    TreeFam Gene Tree for BCL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for BCL6 gene
    BCL6B2  
    Selected SIMAP similar genes for BCL6 using alignment to 8 protein entries:     BCL6_HUMAN (see all proteins) (see all similar genes):
    BACH2    ZNF    Bach2    ZNF818P    BACH1    KLHL3
    DKFZp434J0650    ZBTB21    ZNF78L1    ZNF883    KLHL2    ZNF410
    ZNF55    HIC1    ZBTB3    kr-znf3    KLHL32    ZBTB17

    BCL6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCL6 (see all 706)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131772921,2
    C,F--187308018(+) CTGAGG/ATCAGG 3 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1466385121,2
    C--187308029(+) AGTTCA/GAGACC 3 -- ds50010--------
    rs1398343901,2
    --187308164(+) GAGGCA/GGAGGT 3 -- ds50010--------
    rs46864661,2
    C,F,A,H--187308176(+) GCAGTG/AAGCTG 3 -- ds500112Minor allele frequency- A:0.33NA WA CSA 258
    rs1498245351,2
    --187308187(+) AGATCC/TGAGTC 3 -- ds50010--------
    rs1165590181,2
    F--187308231(+) AAAACA/GAAAGT 3 -- ds50011Minor allele frequency- G:0.02NA 120
    rs559340241,2
    C--187308247(+) GCCTAG/CAGCTG 3 -- ds50014Minor allele frequency- C:0.15WA NA EA 360
    rs793232381,2
    C,F--187308286(+) CTGAGC/GTCTTC 3 -- ds50011Minor allele frequency- G:0.09WA 118
    rs1490547571,2
    --187308401(+) GAGAAA/TGCAGC 3 -- ds50010--------
    rs284772201,2
    C,F--187308455(+) GGAGCT/CGAGGG 3 -- ds50018Minor allele frequency- C:0.27NA WA CSA EA 367

    HapMap Linkage Disequilibrium report for BCL6 (187439165 - 187463515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BCL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664940CNV Deletion23128226
    nsv878077CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL6
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 109565    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
  • Note=Chromosomal aberrations involving BCL6 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL),
    including diffuse large B-cell lymphoma and follicular lymphoma. Approximately 40% of diffuse large B-cell
    lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate
    expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain. Translocation
    t(3;14)(q27;q32). Translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Translocation t(3;7)(q27;p12)
    with IKZF1 gene 5'non-coding region. Translocation t(3;6)(q27;p21) with Histone H4. Translocation
    t(3;16)(q27;p11) with IL21R. Translocation t(3;13)(q27;q14) with LCP1
  • Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation
    t(3;11)(q27;q23) with POU2AF1/OBF1
  • Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11)
    with ARHH/TTF

  • Selected diseases for BCL6 (see all 87):    
    About MalaCards
    primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma    primary bone lymphoma    intravascular large b-cell lymphoma    primary mediastinal large b-cell lymphoma
    heart lymphoma    b-cell lymphomas    testicular lymphoma    lymphoid interstitial pneumonia
    bone lymphoma    lymphoma, follicular, somatic    immunoproliferative small intestinal disease    lenz microphthalmia syndrome
    nodal marginal zone b-cell lymphoma    breast lymphoma    diffuse large b-cell lymphoma of the central nervous system    gastric lymphoma
    follicular lymphoma    diffuse large b-cell lymphoma    plasmablastic lymphoma    central nervous system lymphoma

    6 diseases from the University of Copenhagen DISEASES database for BCL6:
    Lymphoma     Reticulosarcoma     Central nervous system lymphoma     Testicular lymphoma
    Heart lymphoma     Leukemia

    BCL6 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for BCL6 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 93.8 219 19797725 (6), 18925696 (5), 9283593 (4), 7742550 (3) (see all 99)
    lymphoma follicular 90.4 76 18925696 (5), 18500267 (3), 14674895 (3), 10208461 (2) (see all 52)
    lymphoma large cell diffuse 88.1 34 7639334 (3), 9648553 (2), 15998973 (2), 7895484 (1) (see all 25)
    lymphoma 86.1 238 15375218 (5), 12399978 (5), 10626250 (4), 9044511 (3) (see all 99)
    lymphoma non-hodgkins 81.6 87 7742550 (2), 10953971 (2), 16125304 (2), 7472775 (2) (see all 61)
    burkitt lymphoma 76 20 16772123 (3), 9359519 (3), 20079013 (2), 16618762 (2) (see all 12)
    ofcd syndrome 73.3 2 17517692 (1), 15770227 (1)
    malt lymphoma 73.1 43 15153535 (4), 17122510 (3), 11120333 (3), 18166802 (3) (see all 15)
    lymphoid neoplasm 71.4 3 9373196 (1), 8703825 (1), 9209377 (1)
    lymphoma large cell 67 6 11840294 (1), 8703825 (1), 10396291 (1), 9209377 (1) (see all 6)

    Genatlas disease: BCL6
    B-cell,diffuse large-cell lymphoma,follicular lymphoma and mantel cell lymphoma,mucosa-associated lymphoid tissue
    non Hodgkin lymphoma with translocations
    t(3;14)(q27;q32),t(3;13)(q27;q14),t(2;3)(p12;q27),t(3;22)(q27;q11),t(3;4)(q27;p11),t(3;11)(q27;q23),t(3;6)(q27;p21.3),also
    rearranged in some marginal zone B-cell lymphoma,mutated in human herpes-8 positive primary effusion lymphoma
    (PEL)

    Genetic Association Database (GAD): BCL6
    Human Genome Epidemiology (HuGE) Navigator: BCL6 (24 documents)
    Tumor Gene Database (TGDB): BCL6

    Export disorders for BCL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCL6 gene, integrated from 10 sources (see all 656):
    (articles sorted by number of sources associating them with BCL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CtBP is an essential corepressor for BCL6 autoregulation. (PubMed id 18212045)1, 2, 9 Mendez L.M....Ye B.H. (Mol. Cell. Biol. 2008)
    2. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. (PubMed id 11821949)1, 2, 9 Ueda C....Ohno H. (Oncogene 2002)
    3. BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia. (PubMed id 19367498)1, 4, 9 Jantus Lewintre E....GarcA-a-Conde J. (amp 2009)
    4. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. (PubMed id 15577913)1, 2, 9 Phan R.T. and Dalla-Favera R. (Nature 2004)
    5. Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma. (PubMed id 16125304)1, 4, 9 Susova S....Soucek P. (Cancer Lett. 2006)
    6. Clinical and biological relevance of single-nucleotide polymorphisms and acquired somatic mutations of the BCL6 first intron in follicular lymphoma. (PubMed id 16094416)1, 4, 9 Jardin F....Bastard C. (Leukemia 2005)
    7. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large- cell lymphoma. (PubMed id 8235596)1, 2, 9 Ye B.H.... Dalla-Favera R. (Science 1993)
    8. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PubMed id 19336552)1, 4, 9 Morton L.M....Hartge P. (amp 2009)
    9. Structure of the wild-type human BCL6 POZ domain. (PubMed id 19052359)1, 2, 9 Stead M.A....Wright S.C. (Acta Crystallogr. F 2008)
    10. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. (PubMed id 16142238)1, 2, 9 Phan R.T....Dalla-Favera R. (Nat. Immunol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 604 HGNC: 1001 AceView: BCL6 Ensembl:ENSG00000113916 euGenes: HUgn604
    ECgene: BCL6 Kegg: 604 H-InvDB: BCL6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BCL6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCL6 gene:
    Search GeneIP for patents involving BCL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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