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Aliases for BCL6 Gene

Aliases for BCL6 Gene

  • B-Cell CLL/Lymphoma 6 2 3
  • Zinc Finger Protein 51 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 27 3 4
  • B-Cell Lymphoma 5 Protein 3 4
  • Protein LAZ-3 3 4
  • ZBTB27 3 4
  • ZNF51 3 4
  • BCL-5 3 4
  • BCL-6 3 4
  • BCL5 3 4
  • LAZ3 3 4
  • Lymphoma-Associated Zinc Finger Gene On Chromosome 3 3
  • Cys-His2 Zinc Finger Transcription Factor 3
  • Zinc Finger Transcription Factor BCL6S 3
  • B-Cell Lymphoma 6 Protein Transcript 3
  • B-Cell Lymphoma 6 Protein 3
  • BCL6A 3

External Ids for BCL6 Gene

Previous HGNC Symbols for BCL6 Gene

  • ZNF51

Previous GeneCards Identifiers for BCL6 Gene

  • GC03M184254
  • GC03M188700
  • GC03M188841
  • GC03M188760
  • GC03M188921
  • GC03M187439
  • GC03M184843

Summaries for BCL6 Gene

Entrez Gene Summary for BCL6 Gene

  • The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for BCL6 Gene

BCL6 (B-Cell CLL/Lymphoma 6) is a Protein Coding gene. Diseases associated with BCL6 include intravascular large b-cell lymphoma and primary mediastinal large b-cell lymphoma. Among its related pathways are IL4-mediated signaling events and B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is BCL6B.

UniProtKB/Swiss-Prot for BCL6 Gene

  • Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5-TTCCTAGAA-3 (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Gene Wiki entry for BCL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL6 Gene

Genomics for BCL6 Gene

Regulatory Elements for BCL6 Gene

Transcription factor binding sites by QIAGEN in the BCL6 gene promoter:

Genomic Location for BCL6 Gene

Start:
187,721,377 bp from pter
End:
187,745,727 bp from pter
Size:
24,351 bases
Orientation:
Minus strand

Genomic View for BCL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL6 Gene

Proteins for BCL6 Gene

  • Protein details for BCL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41182-BCL6_HUMAN
    Recommended name:
    B-cell lymphoma 6 protein
    Protein Accession:
    P41182
    Secondary Accessions:
    • A7E241
    • B8PSA7
    • D3DNV5

    Protein attributes for BCL6 Gene

    Size:
    706 amino acids
    Molecular mass:
    78846 Da
    Quaternary structure:
    • Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.

    Three dimensional structures from OCA and Proteopedia for BCL6 Gene

    Alternative splice isoforms for BCL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL6 Gene

Proteomics data for BCL6 Gene at MOPED

Post-translational modifications for BCL6 Gene

  • Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.
  • Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
  • Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCL6 Gene

Domains for BCL6 Gene

Gene Families for BCL6 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry

P41182

UniProtKB/Swiss-Prot:

BCL6_HUMAN :
  • P41182
Domain:
  • The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2 (PubMed:18212045). Interaction with corepressors through the BTB domain is needed to facilitate the rapid proliferation and survival of GC B-cells but is not involved in the T(FH) formation and BCL6-mediated suppression of T(H)2 and T(H)17 differentiationrequired for GC formation (By similarity).
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with BCL6: view

Function for BCL6 Gene

Molecular function for BCL6 Gene

GENATLAS Biochemistry: breakpoint in B cell non Hodgkin lymphoma,in translocations t(3;14),t(2;3),t(3;22),t(3;4),t(3;11) and others,same as LAZ3
UniProtKB/Swiss-Prot Function: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5-TTCCTAGAA-3 (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
UniProtKB/Swiss-Prot Induction: Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial lipopolysaccharides (LPS), CD40LG and zymosan. Protein levels decreases upon genotoxic stress in a dose- and time-dependent way.

Gene Ontology (GO) - Molecular Function for BCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IDA 12097386
GO:0003700 sequence-specific DNA binding transcription factor activity IMP 15577913
genes like me logo Genes that share ontologies with BCL6: view
genes like me logo Genes that share phenotypes with BCL6: view

Animal Models for BCL6 Gene

MGI Knock Outs for BCL6:
Targeting motifs for BCL6 Gene
HOMER Transcription Factor Regulatory Elements motif BCL6
  • Consensus sequence: NNNCTTTCCAGGAAA Submotif: canonical Cell Type: Liver GeoId: GSE31578

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for BCL6 Gene

Localization for BCL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL6 Gene COMPARTMENTS Subcellular localization image for BCL6 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10898795
GO:0005657 colocalizes_with replication fork IDA 10490843
genes like me logo Genes that share ontologies with BCL6: view

Pathways for BCL6 Gene

genes like me logo Genes that share pathways with BCL6: view

Pathways by source for BCL6 Gene

1 GeneGo (Thomson Reuters) pathway for BCL6 Gene
1 R&D Systems pathway for BCL6 Gene

Gene Ontology (GO) - Biological Process for BCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IGI 11821949
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11929873
GO:0000902 cell morphogenesis IEA --
GO:0001953 negative regulation of cell-matrix adhesion IEA --
GO:0002467 germinal center formation IEA --
genes like me logo Genes that share ontologies with BCL6: view

Compounds for BCL6 Gene

(17) Novoseek inferred chemical compound relationships for BCL6 Gene

Compound -log(P) Hits PubMed IDs
(h,g)-a-l 73.3 3
cytidine 56.1 4
zinc 51.3 46
rituximab 35.6 5
paraffin 33.4 10
genes like me logo Genes that share compounds with BCL6: view

Transcripts for BCL6 Gene

Unigene Clusters for BCL6 Gene

B-cell CLL/lymphoma 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for BCL6 Gene

GeneLoc Exon Structure for
BCL6
ECgene alternative splicing isoforms for
BCL6

Expression for BCL6 Gene

mRNA expression in normal human tissues for BCL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL6 Gene

This gene is overexpressed in Whole Blood (10.0) and Muscle - Skeletal (6.2).

SOURCE GeneReport for Unigene cluster for BCL6 Gene Hs.478588

mRNA Expression by UniProt/SwissProt for BCL6 Gene

P41182-BCL6_HUMAN
Tissue specificity: Expressed in germinal center T- and B-cells and in primary immature dendritic cells.
genes like me logo Genes that share expressions with BCL6: view

No data available for Protein expression for BCL6 Gene

Orthologs for BCL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL6 35
  • 99.48 (n)
  • 99.72 (a)
BCL6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL6 35
  • 91.41 (n)
  • 95.18 (a)
BCL6 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL6 35
  • 92.45 (n)
  • 96.32 (a)
mouse
(Mus musculus)
Mammalia Bcl6 35
  • 89.19 (n)
  • 94.76 (a)
Bcl6 16
Bcl6 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 15 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BCL6 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl6 35
  • 89.33 (n)
  • 95.18 (a)
chicken
(Gallus gallus)
Aves BCL6 35
  • 77.05 (n)
  • 79.8 (a)
BCL6 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL6 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl6 35
  • 68.21 (n)
  • 68.93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7076 35
zebrafish
(Danio rerio)
Actinopterygii bcl6a 35
  • 64.15 (n)
  • 63.52 (a)
bcl6a 36
  • 59 (a)
OneToMany
bcl6ab 36
  • 48 (a)
OneToMany
zgc73162 35
fruit fly
(Drosophila melanogaster)
Insecta Kr 37
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for BCL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL6 Gene

ENSEMBL:
Gene Tree for BCL6 (if available)
TreeFam:
Gene Tree for BCL6 (if available)

Paralogs for BCL6 Gene

Paralogs for BCL6 Gene

genes like me logo Genes that share paralogs with BCL6: view

Variants for BCL6 Gene

Sequence variations from dbSNP and Humsavar for BCL6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8715 -- 187,737,955(-) GCAGC(G/T)CAGGC upstream-variant-2KB, intron-variant, utr-variant-5-prime
rs954655 -- 187,746,871(+) ACAGT(C/T)TTCTT upstream-variant-2KB
rs1523469 -- 187,745,898(-) AGTTT(A/C/G)TGGGT upstream-variant-2KB
rs1523470 -- 187,742,519(-) AACTG(A/G)GCGAC intron-variant, upstream-variant-2KB
rs1523471 -- 187,742,518(-) ACTGG(A/G)CGACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BCL6 Gene

Variant ID Type Subtype PubMed ID
nsv878077 CNV Gain 21882294
esv2664940 CNV Deletion 23128226

Relevant External Links for BCL6 Gene

HapMap Linkage Disequilibrium report
BCL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL6 Gene

Disorders for BCL6 Gene

UniProtKB/Swiss-Prot

BCL6_HUMAN
  • Note=Chromosomal aberrations involving BCL6 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL), including diffuse large B-cell lymphoma and follicular lymphoma. Approximately 40% of diffuse large B-cell lymphomas and 5 to 10% of follicular lymphomas are associated with chromosomal translocations that deregulate expression of BCL6 by juxtaposing heterologous promoters to the BCL6 coding domain. Translocation t(3;14)(q27;q32). Translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Translocation t(3;7)(q27;p12) with IKZF1 gene 5non-coding region. Translocation t(3;6)(q27;p21) with Histone H4. Translocation t(3;16)(q27;p11) with IL21R. Translocation t(3;13)(q27;q14) with LCP1.
  • Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.
  • Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

(58) Novoseek inferred disease relationships for BCL6 Gene

Disease -log(P) Hits PubMed IDs
lymphoma b-cell 93.8 151
lymphoma follicular 90.4 65
lymphoma large cell diffuse 88.1 29
lymphoma 86.1 149
lymphoma non-hodgkins 81.6 77

Genatlas disease for BCL6 Gene

B-cell,diffuse large-cell lymphoma,follicular lymphoma and mantel cell lymphoma,mucosa-associated lymphoid tissue non Hodgkin lymphoma with translocations t(3;14)(q27;q32),t(3;13)(q27;q14),t(2;3)(p12;q27),t(3;22)(q27;q11),t(3;4)(q27;p11),t(3;11)(q27;q23),t(3;6)(q27;p21.3),also rearranged in some marginal zone B-cell lymphoma,mutated in human herpes-8 positive primary effusion lymphoma (PEL)

Relevant External Links for BCL6

Genetic Association Database (GAD)
BCL6
Human Genome Epidemiology (HuGE) Navigator
BCL6
Tumor Gene Database (TGDB):
BCL6
genes like me logo Genes that share disorders with BCL6: view

Publications for BCL6 Gene

  1. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large- cell lymphoma. (PMID: 8235596) Ye B.H. … Dalla-Favera R. (Science 1993) 3 4 23
  2. Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein. (PMID: 8274740) Miki T. … Aoki N. (Blood 1994) 3 4 23
  3. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. (PMID: 9649500) Niu H. … Dalla-Favera R. (Genes Dev. 1998) 3 4 23
  4. The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. (PMID: 11821949) Ueda C. … Ohno H. (Oncogene 2002) 3 4 23
  5. A polymorphism in the BCL-6 gene is associated with follicle center lymphoma. (PMID: 11911418) Lossos I.S. … Levy R. (Leuk. Lymphoma 2001) 3 23 48

Products for BCL6 Gene

  • Addgene plasmids for BCL6

Sources for BCL6 Gene

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