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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL6 Gene

protein-coding   GIFtS: 68
GCID: GC03M187439

B-Cell CLL/Lymphoma 6

(Previous name: zinc finger protein 51)
(Previous symbol: ZNF51)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 61 2     ZBTB272 3
Zinc Finger Protein 511 2 3     B-Cell Lymphoma 5 Protein2 3
ZNF511 2 3     BCL6A2
Protein LAZ-32 3     B-Cell Lymphoma 6 Protein2
Zinc Finger And BTB Domain-Containing Protein 272 3     B-Cell Lymphoma 6 Protein Transcript2
BCL-52 3     Cys-His2 Zinc Finger Transcription Factor2
BCL-62 3     Lymphoma-Associated Zinc Finger Gene On Chromosome 32
BCL52 3     Zinc Finger Transcription Factor BCL6S2
LAZ32 3     

External Ids:    HGNC: 10011   Entrez Gene: 6042   Ensembl: ENSG000001139167   OMIM: 1095655   UniProtKB: P411823   

Export aliases for BCL6 gene to outside databases

Previous GC identifers: GC03M184254 GC03M188700 GC03M188841 GC03M188760 GC03M188921 GC03M184843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL6 Gene:
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This
protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription
of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins
that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in
diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced
transcript variants encoding different protein isoforms have been found for this gene. (provided by RefSeq, Sep
2008)

GeneCards Summary for BCL6 Gene: 
BCL6 (B-cell CLL/lymphoma 6) is a protein-coding gene. Diseases associated with BCL6 include primary mediastinal large b-cell lymphoma, and primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma, and among its related super-pathways are Immune response Fc epsilon RI pathway and Wnt Signaling Pathway. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF131.

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
Function: Transcriptional repressor which is required for germinal center formation and antibody affinity
maturation. Probably plays an important role in lymphomagenesis

Gene Wiki entry for BCL6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL6 gene promoter:
         AP-1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27

BCL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M187439:  view genomic region     (about GC identifiers)

Start:
187,439,165 bp from pter      End:
187,463,515 bp from pter
Size:
24,351 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182 (See protein sequence)
Recommended Name: B-cell lymphoma 6 protein  
Size: 706 amino acids; 78846 Da
Subunit: Homodimer. Interacts (via BTB domain) with BCOR; the interaction is direct. Interacts (via BTB domain)
with NCOR2; the interaction is direct. Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the
catalytic domain of HDAC9
Subcellular location: Nucleus (By similarity)
6/10 PDB 3D structures from and Proteopedia for BCL6 (see all 10):
1R28 (3D)        1R29 (3D)        1R2B (3D)        2EN2 (3D)        2EOS (3D)        2LCE (3D)    
Secondary accessions: A7E241 B8PSA7 D3DNV5
Alternative splicing: 2 isoforms:  P41182-1   P41182-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCL6: NX_P41182

Explore proteomics data for BCL6 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylation induces
    its degradation by ubiquitin/proteasome pathway
  • UniProtKB: Polyubiquitinated. Polyubiquitination leads to degradation by the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41182

  • BCL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCL6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001124317.1  NP_001128210.1  NP_001697.2  

    ENSEMBL proteins: 
     ENSP00000384371   ENSP00000398014   ENSP00000232014   ENSP00000413122   ENSP00000415574  
     ENSP00000414455  

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    Novus Biologicals BCL6 Proteins
    Novus Biologicals BCL6 Lysate
    Sino Biological Recombinant Protein for BCL6
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for BCL6
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005657colocalizes with replication fork IDA10490843
    GO:0005730NOT nucleolus IDA--

    BCL6 for ontologies           About GeneDecksing



    BCL6 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P41182

    ProtoNet protein and cluster: P41182

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
    Domain: The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to
    corepressors BCOR and NCOR2
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 C2H2-type zinc fingers


    BCL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL6_HUMAN, P41182
    Function: Transcriptional repressor which is required for germinal center formation and antibody affinity
    maturation. Probably plays an important role in lymphomagenesis
    Induction: Down-regulated during maturation of dendritic cells by selective stimuli such as bacterial
    lipopolysaccharides (LPS), CD40LG and zymosan

         Genatlas biochemistry entry for BCL6:
    breakpoint in B cell non Hodgkin lymphoma,in translocations t(3;14),t(2;3),t(3;22),t(3;4),t(3;11) and others,same
    as LAZ3

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IDA12097386
    GO:0003700sequence-specific DNA binding transcription factor activity IMP15577913
    GO:0005515protein binding IPI10898795
    GO:0008270zinc ion binding ----
         
    BCL6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BCL6:
     Increased cell death HMECs cel  Increased homologous recombina  Synthetic lethal with c-Myc af 

         12 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Bcl6):
     cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  no phenotypic analysis 
     reproductive system  respiratory system 

    BCL6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BCL6: Bcl6tm1Sdt Bcl6tm1Rdf Bcl6tm1Tto Bcl6tm2Rdf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCL6 
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL6 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL6
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL6 (see all 49):
    hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-30d hsa-miR-632 hsa-miR-346 hsa-miR-519a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidBCL6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL6
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCL6 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.45
    2Wnt Signaling Pathway
    DNA damage response (only ATM dependent)0.32
    3Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    4Signaling events mediated by HDAC Class II
    Signaling events mediated by HDAC Class II
    5Selected targets of p53
    Selected targets of p53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for BCL6
        Immune response BCR pathway
    Selected targets of p53

    1 R&D Systems Pathway for BCL6
        Notch Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for BCL6
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for BCL6
        Immune response BCR pathway

    5/6 BioSystems Pathways for BCL6 (see all 6)
        DNA damage response (only ATM dependent)
    B Cell Receptor Signaling Pathway
    FoxO family signaling
    Signaling events mediated by HDAC Class II
    Direct p53 effectors



    1         Kegg Pathway  (Kegg details for BCL6):
        Transcriptional misregulation in cancer


    BCL6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/121 Interacting proteins for BCL6 (P411821, 2, 3 ENSP000002320144) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565241, 3, ENSP000002646064EBI-765407,EBI-308629 I2D: score=3 STRING: ENSP00000264606
    HDAC9Q9UKV01, 3, ENSP000004086174EBI-765407,EBI-765444 I2D: score=3 STRING: ENSP00000408617
    ZMYND8Q9ULU41, 3, ENSP000004182104EBI-765407,EBI-765834 I2D: score=3 STRING: ENSP00000418210
    ARHGAP35Q9NRY43, ENSP000003857204I2D: score=3 STRING: ENSP00000385720
    BCL6BQ8N1433, ENSP000002938054I2D: score=3 STRING: ENSP00000293805
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IGI11821949
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11929873
    GO:0000902cell morphogenesis IEA--
    GO:0001953negative regulation of cell-matrix adhesion IEA--
    GO:0002467germinal center formation IEA--

    BCL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCL6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCL6

    10/17 Novoseek inferred chemical compound relationships for BCL6 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (h,g)-a-l 73.3 3 17296566 (1), 17038524 (1), 19234720 (1)
    cytidine 56.1 4 16380510 (1), 16895557 (1), 15188366 (1), 12818155 (1)
    zinc 51.3 57 11854457 (3), 9135990 (3), 10757802 (2), 20175752 (2) (see all 35)
    rituximab 35.6 8 19797725 (3), 19786664 (1), 16449523 (1)
    paraffin 33.4 12 10843287 (2), 15723651 (1), 9209651 (1), 10208461 (1) (see all 9)
    vincristine 32.1 2 19786664 (1), 16449523 (1)
    cyclophosphamide 18.8 2 19786664 (1), 16449523 (1)
    doxorubicin 9.46 2 19786664 (1), 16449523 (1)
    estrogen 5.29 5 19824433 (1), 12165517 (1)
    serine 3.76 2 12881702 (1), 9188861 (1)

    Search CenterWatch for drugs/clinical trials and news about BCL6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCL6 gene (4 alternative transcripts): 
    NM_001130845.1  NM_001134738.1  NM_001706.4  NM_138931.1  

    Unigene Cluster for BCL6:

    B-cell CLL/lymphoma 6
    Hs.478588  [show with all ESTs]
    Unigene Representative Sequence: NM_001130845
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406870(uc011bsf.1 uc003frq.2) ENST00000419510(uc003frp.3 uc010hza.2)
    ENST00000232014 ENST00000450123 ENST00000479110 ENST00000430339 ENST00000480458
    ENST00000438077 ENST00000470319 ENST00000496823
    miRNA
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    hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-30d hsa-miR-632 hsa-miR-346 hsa-miR-519a hsa-miR-374c
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    Additional mRNA sequence: 

    AK090890.1 AK304325.1 AK308162.1 AL713713.1 AL832990.1 BC142705.1 BC146796.1 BC150184.1 
    EU139066.1 EU883531.1 U00115.1 Z21943.1 

    15 DOTS entries:

    DT.99956826  DT.99978801  DT.454834  DT.212094  DT.91757283  DT.100817094  DT.120907804  DT.120907845 
    DT.443706  DT.100662547  DT.100662593  DT.100735246  DT.87016782  DT.95345389  DT.120907853 

    24/195 AceView cDNA sequences (see all 195):

    AU279518 W95815 BQ722826 AI659577 AW302390 NM_138931 BU428597 AA371071 
    AW576580 BF924437 BM454297 S67779 NM_001706 AA447608 BM801045 AI080223 
    T27711 W81333 AA749422 AA448107 BX419860 AI362271 BQ716058 W95808 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL6    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -                                                                     
    SP2:                    -           -                                                         
    SP3:                                                              -                           
    SP4:                                                                                          


    ECgene alternative splicing isoforms for BCL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL6 expression in normal human tissues (normalized intensities)      BCL6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTGTTAT
    BCL6 Expression
    About this image


    BCL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Inner Cell Mass (Early Embryonic Tissues)
             CyT49
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End

    See BCL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL6

    SOURCE GeneReport for Unigene cluster: Hs.478588

    UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
    Tissue specificity: Expressed in germinal center T and B-cells and in primary immature dendritic cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BCL6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl61 , 5 B cell leukemia/lymphoma 61, 5 89.19(n)1
    94.76(a)1
      16 (15.26 cM)5
    120531  NM_009744.31  NP_033874.11 
     239650525 
    chicken
    (Gallus gallus)
    Aves BCL61 B-cell CLL/lymphoma 6 77.29(n)
    80.09(a)
      424912  NM_001012930.1  NP_001012948.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL66
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343905.1(115608-137758)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731622 B-cell lymphoma 6 protein 76.5(n)   393707  BC059515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kr3 axon guidance DNA binding 51(a)   2 60F5   --


    ENSEMBL Gene Tree for BCL6 (if available)
    TreeFam Gene Tree for BCL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCL6 gene
    ZNF1312  BCL6B2  
    18/98 SIMAP similar genes for BCL6 using alignment to 8 protein entries:     BCL6_HUMAN (see all proteins) (see all similar genes):
    BACH2    ZNF    ZNF818P    BACH1    KLHL3    DKFZp434J0650
    ZBTB21    ZNF78L1    ZNF883    KLHL2    ZNF410    ZNF55
    HIC1    ZBTB3    kr-znf3    KLHL32    ZBTB17    ZBTB49

    BCL6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/706 SNPs in BCL6 are shown (see all 706)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131772921,2
    C,F--187308018(+) CTGAGG/ATCAGG 3 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1466385121,2
    C--187308029(+) AGTTCA/GAGACC 3 -- ds50010--------
    rs1398343901,2
    --187308164(+) GAGGCA/GGAGGT 3 -- ds50010--------
    rs46864661,2
    C,F,A,H--187308176(+) GCAGTG/AAGCTG 3 -- ds500112Minor allele frequency- A:0.33NA WA CSA 258
    rs1498245351,2
    --187308187(+) AGATCC/TGAGTC 3 -- ds50010--------
    rs1165590181,2
    F--187308231(+) AAAACA/GAAAGT 3 -- ds50011Minor allele frequency- G:0.02NA 120
    rs559340241,2
    C--187308247(+) GCCTAG/CAGCTG 3 -- ds50014Minor allele frequency- C:0.15WA NA EA 360
    rs793232381,2
    C,F--187308286(+) CTGAGC/GTCTTC 3 -- ds50011Minor allele frequency- G:0.09WA 118
    rs1490547571,2
    --187308401(+) GAGAAA/TGCAGC 3 -- ds50010--------
    rs284772201,2
    C,F--187308455(+) GGAGCT/CGAGGG 3 -- ds50018Minor allele frequency- C:0.27NA WA CSA EA 367

    HapMap Linkage Disequilibrium report for BCL6 (187439165 - 187463515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BCL6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664940CNV Deletion23128226
    nsv878077CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109565    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCL6_HUMAN, P41182
  • Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation
    t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions
  • Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation
    t(3;11)(q27;q23) with POU2AF1/OBF1
  • Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11)
    with ARHH/TTF

  • 20/82 diseases for BCL6 (see all 82):    About MalaCards
    primary mediastinal large b-cell lymphoma    primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma    primary bone lymphoma    bone lymphoma
    lenz microphthalmia syndrome    lymphoid interstitial pneumonia    testicular lymphoma    immunoproliferative small intestinal disease
    diffuse large b-cell lymphoma of the central nervous system    breast lymphoma    nodal marginal zone b-cell lymphoma    diffuse large b-cell lymphoma
    nodular lymphocyte predominant hodgkin lymphoma    follicular lymphoma    gastric lymphoma    central nervous system lymphoma
    plasmablastic lymphoma    angioimmunoblastic t-cell lymphoma    reticulosarcoma    b-cell lymphomas

    6 diseases from the University of Copenhagen DISEASES database for BCL6:
    Lymphoma     Reticulosarcoma     Central nervous system lymphoma     Testicular lymphoma
    Heart lymphoma     Leukemia

    BCL6 for disorders           About GeneDecksing

    10/58 Novoseek inferred disease relationships for BCL6 gene (see all 58)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 93.8 219 19797725 (6), 18925696 (5), 9283593 (4), 7742550 (3) (see all 99)
    lymphoma follicular 90.4 76 18925696 (5), 18500267 (3), 14674895 (3), 10208461 (2) (see all 52)
    lymphoma large cell diffuse 88.1 34 7639334 (3), 9648553 (2), 15998973 (2), 7895484 (1) (see all 25)
    lymphoma 86.1 238 15375218 (5), 12399978 (5), 10626250 (4), 9044511 (3) (see all 99)
    lymphoma non-hodgkins 81.6 87 7742550 (2), 10953971 (2), 16125304 (2), 7472775 (2) (see all 61)
    burkitt lymphoma 76 20 16772123 (3), 9359519 (3), 20079013 (2), 16618762 (2) (see all 12)
    ofcd syndrome 73.3 2 17517692 (1), 15770227 (1)
    malt lymphoma 73.1 43 15153535 (4), 17122510 (3), 11120333 (3), 18166802 (3) (see all 15)
    lymphoid neoplasm 71.4 3 9373196 (1), 8703825 (1), 9209377 (1)
    lymphoma large cell 67 6 11840294 (1), 8703825 (1), 10396291 (1), 9209377 (1) (see all 6)

    Genatlas disease: BCL6
    B-cell,diffuse large-cell lymphoma,follicular lymphoma and mantel cell lymphoma,mucosa-associated lymphoid tissue
    non Hodgkin lymphoma with translocations
    t(3;14)(q27;q32),t(3;13)(q27;q14),t(2;3)(p12;q27),t(3;22)(q27;q11),t(3;4)(q27;p11),t(3;11)(q27;q23),t(3;6)(q27;p21.3),also
    rearranged in some marginal zone B-cell lymphoma,mutated in human herpes-8 positive primary effusion lymphoma
    (PEL)

    Genetic Association Database (GAD): BCL6
    Human Genome Epidemiology (HuGE) Navigator: BCL6 (24 documents)
    Tumor Gene Database (TGDB): BCL6

    Export disorders for BCL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL6 gene, integrated from 9 sources (see all 646):
    (articles sorted by number of sources associating them with BCL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia. (PubMed id 19367498)1, 4, 9 Jantus Lewintre E....GarcA-a-Conde J. (2009)
    2. Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma. (PubMed id 16125304)1, 4, 9 Susova S....Soucek P. (2006)
    3. Clinical and biological relevance of single-nucleotide polymorphisms and acquired somatic mutations of the BCL6 first intron in follicular lymphoma. (PubMed id 16094416)1, 4, 9 Jardin F....Bastard C. (2005)
    4. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large- cell lymphoma. (PubMed id 8235596)1, 2, 9 Ye B.H.... Dalla-Favera R. (1993)
    5. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PubMed id 19336552)1, 4, 9 Morton L.M....Hartge P. (2009)
    6. Structure of the wild-type human BCL6 POZ domain. (PubMed id 19052359)1, 2, 9 Stead M.A....Wright S.C. (2008)
    7. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. (PubMed id 14690607)1, 2, 9 Ahmad K.F....Prive G.G. (2003)
    8. A polymorphism in the BCL-6 gene is associated with follicle center lymphoma. (PubMed id 11911418)1, 4, 9 Lossos I.S....Levy R. (2001)
    9. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. (PubMed id 9649500)1, 2, 9 Niu H.... Dalla-Favera R. (1998)
    10. Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kruppel-like zinc-finger protein. (PubMed id 8274740)1, 2, 9 Miki T.... Aoki N. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 604 HGNC: 1001 AceView: BCL6 Ensembl:ENSG00000113916 euGenes: HUgn604
    ECgene: BCL6 Kegg: 604 H-InvDB: BCL6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCL6 gene:
    Search GeneIP for patents involving BCL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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