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BCL3 Gene

protein-coding GIFtS: 66

GC19P049943

B-cell CLL/lymphoma 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: D19S37, BCL4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCL4 ^², ³
D19S37 ^², ³

Descriptions
B-cell CLL/lymphoma 3 ^²
B-cell leukemia/lymphoma 3 ^²
B-cell lymphoma 3-encoded protein ^²
Protein Bcl-3 ^³
chronic lymphatic leukemia protein ^²

External Ids
HGNC: 998¹
Entrez Gene: 602²
UniProtKB: P20749³
Ensembl: ENSG00000069399⁷

Search outside databases for aliases for BCL3 gene

Previous GC identifers: GC19P045896 GC19P045642 GC19P049927

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BCL3:

This gene is a proto-oncogene candidate. It is identified by its translocation into the

immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene

contains seven ankyrin repeats, which are most closely related to those found in I kappa B

proteins. This protein functions as a transcriptional co-activator that activates through its

association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B,

which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa

B. [provided by RefSeq]

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749

Function: Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific

for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus

Gene Wiki entry for BCL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BCL3 gene

Entrez Gene cytogenetic band: 19q13.1-q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.1-q13.2

BCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P049943: (about GC identifiers)

Start:	49,943,644 bp from pter
End:	49,955,141 bp from pter
Size:	11,498 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749 (See protein sequence)

Recommended Name: B-cell lymphoma 3-encoded protein

Size: 446 amino acids; 46800 Da

Subunit: Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component

of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2 and

COPS5

Subcellular location: Nucleus

PDB structure from and Proteopedia :

1K1A (3D)

1K1B (3D)

Post-translational modifications:

Activated by phosphorylation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005169.2

ENSEMBL proteins:

ENSP00000384024 ENSP00000164227

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bcl3)
	Human Recombinant Proteins from Abnova (BCL3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	8196632 16280327 16306601
GO:0005737	cytoplasm	IDA	11387332
GO:0032996	Bcl3-Bcl10 complex	IDA	16280327
GO:0033257	Bcl3/NF-kappaB2 complex	IDA	9407099

About this table

Antibodies for BCL3:

	Invitrogen Antibodies for BCL3
	Millipore Mono- and Polyclonal Antibodies for the study of BCL3
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Bcl3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BCL3)
	Novus Biologicals Antibodies for BCL3

Assays for BCL3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20749

ProtoNet protein and cluster: P20749

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749

Similarity: Contains 7 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL3)
		Millipore RNAi Products for the Analysis of BCL3 Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005178

Applied Biosystems Silencer® siRNAs for BCL3

Sigma-Aldrich siRNA and siRNA Panels for BCL3

Sigma-Aldrich shRNA Panels and shRNA for BCL3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BCL3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005178
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005178
untagged cDNA clones in CMV expression vector (see all 2): NM_005178

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005178

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749

Function: Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific

for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus

Genatlas biochemistry entry for BCL3:

inhibitor of REL/NFKB transcription factors,IKB (NFKBI) family

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Bcl3):

hematopoietic system

homeostasis/metabolism

immune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0008134	transcription factor binding	IPI	8196632 11387332 16108830 16306601
GO:0030674	protein binding, bridging	TAS	16306601

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/40 Sigma-Aldrich "Your Favorite Gene" Pathways for BCL3 (Your Favorite Gene powered by Ingenuity) (see all 40 )

Induction of Apoptosis by HIV1
Erythropoietin Signaling
TR/RXR Activation
IL-6 Signaling
Dendritic Cell Maturation

GeneDecks BCL3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BCL3

5/45 Interacting proteins for BCL3 (ENSP00000164227³ P20749^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL10	O95999¹	STRING (score=.812) EBI-958997, EBI-958922
NFKB1	P19838²	STRING (score=.999) MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544
NFKB2	Q00653²	STRING (score=.999) MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544
REL	Q04864²	STRING (score=.992) MINT-6178520 MINT-6178504 MINT-6178544
RELA	Q04206²	STRING (score=.994) MINT-6178467 MINT-6178520 MINT-6178544

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5/30 Gene Ontology (GO) biological process terms (links to tree view) (see all 30 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IMP	16280327
GO:0002268	follicular dendritic cell differentiation	IEA	--
GO:0002315	marginal zone B cell differentiation	IEA	--
GO:0002455	humoral immune response mediated by circulating immunoglobulin	IEA	--
GO:0002467	germinal center formation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for BCL3 available from Tocris Bioscience
2 Novoseek chemical compound relationships for BCL3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]	55.76	6	16123212 (3), 16108830 (2)
tyrosine	0.00	7	16099425 (3), 9576921 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL3)
		Millipore RNAi Products for the Analysis of BCL3 Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005178

Sigma-Aldrich siRNA and siRNA Panels for BCL3

Sigma-Aldrich shRNA Panels and shRNA for BCL3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005178

REFSEQ mRNAs for BCL3 gene:

NM_005178.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005178

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005178
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005178
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005178

Additional cDNA sequence:

AK296180.1 AK309453.1 BC064993.1 M31732.1

7 DOTS entries:

DT.313673 DT.121499920 DT.91651190 DT.91756691 DT.121499915 DT.91981506 DT.95169089

24/128 AceView cDNA sequences (see all 128 ):

BM713016 BU145268 CA392189 CD678867 BM676215 BM918173 BF001239 BQ673686

AI347138 BM708626 BU501187 BF590941 BM759970 AI168170 BC064993 BI084242

BQ669654 CA392190 BQ670418 BQ673772 AA293187 BQ877688 AI580285 BM560834

highest scoring ESTs for BCL3:

AA064651 AA293187 AA307228 AA594356 AA631354 AA845677 AI205817 AV705787 AW084504 AW364291

Unigene Cluster for BCL3:

B-cell CLL/lymphoma 3

Hs.31210 [show with all ESTs]

Unigene Representative Sequence: BC064993

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL3

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b
SP1:													-								-
SP2:													-
SP3:																					-
SP4:

About this scheme

ECgene alternative splicing isoforms for BCL3

2 Ensembl transcripts including schematic representations:

ENST00000403534 ENST00000164227

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BCL3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCL3

¹ / ² / ³

5 probe-sets matching BCL3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1796_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U05681	0.20	1.00	0.72	1
204908_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005178	0.60	1.00	0.82	1
204907_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI829875	0.60	1.00	0.82	1
204908_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204907_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.31210
Expression variation in blood from EXPOLDB for BCL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BCL3 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCL3¹	--	B-cell CLL/lymphoma 3	78.57(n) 78.11(a)	612349 XM_850082.1 XP_855175.1
cow (Bos taurus)	BCL3¹	--	B-cell CLL/lymphoma 3	89.24(n) 90.13(a)	531942 XM_610447.3 XP_610447.3
rat (Rattus norvegicus)	Bcl3¹	--	B-cell CLL/lymphoma 3	82.35(n) 82.95(a)	680611 XM_001057993.1 XP_001057993.1
mouse (Mus musculus)	Bcl3^{1, 5}	7 (6.50 cM)⁵	B-cell leukemia/lymphoma 3^{1, 5}	82.27(n)¹ 82.27(a)¹	12051¹ NM_033601.1¹ NP_291079.1¹ AF067774⁵ AI450238⁵ (see all 13)
zebrafish (Danio rerio)	LOC565656¹	--	similar to B-cell lymphoma 3-encoded protein (Protein more	54.07(n) 55.52(a)	565656 XM_688922.3 XP_694014.3

About this table Species with no ortholog for BCL3

ENSEMBL Gene Tree for BCL3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BCL3 gene

NFKBID² NFKBIZ²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/105 NCBI SNPs in BCL3 are shown (see all 105 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 32)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2965170^1,2	A,C,F,H	49942348(-)	`CCCTGG/AGACCT`	1	--	ng5¹ tfbs³		4		EU EA WA	412
	rs2965169^1,2	A,C	49942996(-)	`TGCACG/TCGTTG`	1	--	ng5¹		0	--	--	--	--
	rs1079086^1,2	C,F	49942204(+)	`GGGAGA/GTCCAG`	1	--	ng5¹		4		EA NA MN	242
	rs873470^1,2	F,H	49942756(-)	`GATGGG/ATGGGG`	1	--	ng5¹		8		EA NA MN EU WA	658
--	rs2006134^1,2	A	49955468(+)	`TCAAGC/TGATTC`	1	--	ng3¹		0	--	--	--	--
--	rs1046881^1,2	F	49954765(+)	`CCCTGT/AGGGGT`	1	--	ut3¹		1		MN	184
--	rs12460388^1,2	C	49942171(+)	`GTGCTC/TGGGAT`	1	--	ng5¹		0	--	--	--	--
	rs2927457^1,2	A,C,F,H	49948787(-)	`GGGGAC/TCCAGA`	1	--	int¹		4		EU EA WA	412
	rs8100239^1,2	A,C,F,H	49944944(+)	`GAAAAT/ATTCAG`	1	--	int¹		12		EU EA WA	1256
	rs8103315^1,2	C,F,H	49946008(+)	`CAGTCC/ACTGGG`	1	--	int¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for BCL3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109560

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749

A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic

leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions

10/24 Novoseek disease relationships for BCL3 gene (see all 24 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia lymphocytic chronic	76.80	15	15716244 (2), 2243504 (2), 8011990 (2), 17644518 (1) (see all 12)
lymphocytic leukemia chronic b-cell	72.69	4	8336935 (1), 8011990 (1), 11713278 (1), 16533741 (1)
lymphoma t-cell peripheral	59.66	2	15105810 (1), 16123212 (1)
lymphoma b-cell	55.81	6	15105810 (1), 11672772 (1), 18052923 (1), 16384933 (1)
trisomy	55.56	2	9078289 (1), 15716244 (1)
lymphoma non-hodgkins	54.13	8	2243504 (2), 15105810 (1), 12835724 (1), 8011990 (1) (see all 6)
lymphoid neoplasm	50.16	1	15105810 (1)
anaplastic large cell lymphoma	49.04	3	16108830 (1), 12456498 (1), 16533741 (1)
lymphoma follicular	48.21	6	8400234 (3), 15105810 (1), 1923524 (1)
hodgkin disease	44.87	8	15105810 (3), 15716244 (1), 12456498 (1), 16533741 (1)

About this table

Genatlas disease: BCL3

B cell lymphoma with translocation t(14;19)(q32;q13.1)

Genetic Association Database: BCL3
Human Genome Epidemiology Navigator: BCL3 (5 documents)
Tumor Gene Database: BCL3

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/112 PubMed articles for BCL3 gene (see all 112 ):

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. (PubMed id 2180580)^{1, 2, 3, 4} Ohno H....McKeithan T.W. (1990)
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. (PubMed id 15469820)^{1, 3, 4} Viatour P....Chariot A. (2004)
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. (PubMed id 11707390)^{1, 3, 4} Michel F....Muller C.W. (2001)
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. (PubMed id 8453667)^{1, 3, 4} Bours V....Siebenlist U. (1993)
Genomic structure of the candidate proto-oncogene BCL3. (PubMed id 7896265)^{1, 3, 4} McKeithan T.W.... Hume E. (1994)
[Possible association due to linkage disequilibrium of TGFA, RARA and BCL3 with nonsyndromic cleft lip with or without cleft palate in the Chilean population] (PubMed id 16311697)^{3, 6} Suazo J....Blanco R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. (PubMed id 12730195)^{3, 4} Watanabe N.... Fujita T. (2003)
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. (PubMed id 10362352)^{3, 4} Dechend R.... Leutz A. (1999)
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. (PubMed id 10469655)^{3, 4} Heissmeyer V.... Scheidereit C. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 602	HGNC: 998	AceView: BCL3	Ensembl:ENSG00000069399	euGenes: HUgn602
ECgene: BCL3	H-InvDB: BCL3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BCL3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BCL3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BCL3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BCL3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BCL3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BCL3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for BCL3

Tocris compounds for BCL3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BCL3

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BCL3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for BCL3

Summaries
for BCL3

Genomic Location
for BCL3

Proteins
for BCL3

Protein Domains/
Families
for BCL3

Gene Function
for BCL3

Pathways & Interactions
for BCL3

Drugs & Compounds
for BCL3

Transcripts
for BCL3

Expression
for BCL3

Orthologs
for BCL3

Paralogs
for BCL3

SNPs/Variants
for BCL3

Disorders & Mutations
for BCL3

Medical News
for BCL3

Publications
for BCL3

Search for BCL3

Genome Databases showing BCL3

Other Databases showing BCL3

Specialized Databases showing BCL3

Licensable Technologies
for BCL3

Services
for BCL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BCL3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor BCL3

Summariesfor BCL3

Genomic Locationfor BCL3

Proteinsfor BCL3

Protein Domains/Familiesfor BCL3

Gene Functionfor BCL3

Pathways & Interactionsfor BCL3

Drugs & Compoundsfor BCL3

Transcriptsfor BCL3

Expression for BCL3

Orthologsfor BCL3

Paralogsfor BCL3

SNPs/Variantsfor BCL3

Disorders & Mutationsfor BCL3

Medical Newsfor BCL3

Publicationsfor BCL3

Search for BCL3

Genome Databases showing BCL3

Other Databases showing BCL3

Specialized Databases showing BCL3

Licensable Technologiesfor BCL3

Servicesfor BCL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BCL3

Summaries
for BCL3

Genomic Location
for BCL3

Proteins
for BCL3

Protein Domains/
Families
for BCL3

Gene Function
for BCL3

Pathways & Interactions
for BCL3

Drugs & Compounds
for BCL3

Transcripts
for BCL3

Expression
for BCL3

Orthologs
for BCL3

Paralogs
for BCL3

SNPs/Variants
for BCL3

Disorders & Mutations
for BCL3

Medical News
for BCL3

Publications
for BCL3

Licensable Technologies
for BCL3

Services
for BCL3