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BCL3 Gene

protein-coding   GIFtS: 61
GCID: GC19P045250

B-Cell CLL/Lymphoma 3


(Previous symbols: D19S37, BCL4)
  See BCL3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B-Cell CLL/Lymphoma 31 2     Chronic Lymphatic Leukemia Protein1 2
BCL41 2 3     Proto-Oncogene BCL32 3
D19S371 2 3     BCL-32 3
B-Cell Leukemia/Lymphoma 31 2     B-Cell Lymphoma 3 Protein2
B-Cell Lymphoma 3-Encoded Protein1 2     

External Ids:    HGNC: 9981   Entrez Gene: 6022   Ensembl: ENSG000000693997   OMIM: 1095605   UniProtKB: P207493   

Export aliases for BCL3 gene to outside databases

Previous GC identifers: GC19P045896 GC19P045642 GC19P049927 GC19P049943 GC19P041684


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCL3 Gene:
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus
in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most
closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator
that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by
NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
(provided by RefSeq, Jul 2008)

GeneCards Summary for BCL3 Gene:
BCL3 (B-cell CLL/lymphoma 3) is a protein-coding gene. Diseases associated with BCL3 include leukemia/lymphoma, b-cell, 3, and mature b-cell neoplasm. GO annotations related to this gene include protein binding, bridging and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749
Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the
cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as
transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation
of cell proliferation (By similarity)

Gene Wiki entry for BCL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCL3 gene promoter:
         STAT5B   STAT1   Lmo2   Olf-1   AP-2gamma   NF-kappaB   C/EBPalpha   GATA-2   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL3 promoter sequence
   Search Chromatin IP Primers for BCL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.1-q13.2

BCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045250:  view genomic region     (about GC identifiers)

Start:
45,250,962 bp from pter      End:
45,263,301 bp from pter
Size:
12,340 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749 (See protein sequence)
Recommended Name: B-cell lymphoma 3 protein  
Size: 454 amino acids; 47584 Da
Subunit: Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex
consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD
(By similarity)
Caution: It is uncertain whether Met-1 or Met-9 is the initiator
Sequence caution: Sequence=AAA51815.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA51816.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH64993.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for BCL3:
1K1A (3D)        1K1B (3D)    

Explore the universe of human proteins at neXtProt for BCL3: NX_P20749

Explore proteomics data for BCL3 at MOPED

Post-translational modifications: 

  • Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
    Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents
    nuclear accumulation (By similarity)1
  • Activated by phosphorylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BCL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005169.2  
    ENSEMBL proteins: 
     ENSP00000164227   ENSP00000393731  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P20749

    ProtoNet protein and cluster: P20749

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749
    Similarity: Contains 7 ANK repeats


    Find genes that share domains with BCL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL3_HUMAN, P20749
    Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the
    cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as
    transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation
    of cell proliferation (By similarity)

         Genatlas biochemistry entry for BCL3:
    inhibitor of REL/NFKB transcription factors,IKB (NFKBI) family

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10362352
    GO:0008134transcription factor binding IPI11387332
    GO:0030674protein binding, bridging TAS16306601
         
    Find genes that share ontologies with BCL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL3:
     Increased cell number in S 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Bcl3):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with BCL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BCL3: Bcl3tm1Sbn Bcl3tm1Ver Bcl3tm1Rsch Bcl3tm1Rie

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL3
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    Selected qRT-PCR Assays for microRNAs that regulate BCL3 (see all 13):
    hsa-miR-4324 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidBCL3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BCL3_HUMAN, P20749: Nucleus. Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity).
    Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0032996Bcl3-Bcl10 complex IDA16280327
    GO:0033257Bcl3/NF-kappaB2 complex IDA9407099

    Find genes that share ontologies with BCL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCL3 About    
    See pathways by source

    SuperPathContained pathways About
    1IL-9 Signaling Pathways
    Immune response IL 9 signaling pathway0.42
    IL-9 Pathway0.36
    2NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    3TNF signaling pathway
    TNF signaling pathway
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    5Atypical NF-kappaB pathway
    Atypical NF-kappaB pathway


    Find genes that share SuperPaths with BCL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BCL3
        IL-9 Pathway
    NF-KappaB Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for BCL3
        Immune response IL-9 signaling pathway

    2 BioSystems Pathways for BCL3
        TNF-alpha/NF-kB Signaling Pathway
    Atypical NF-kappaB pathway


    1 Kegg Pathway  (Kegg details for BCL3):
        TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL3: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCL3 (P207491, 2, 3 ENSP000001642274) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062391, 2, 3, ENSP000003378254EBI-958997,EBI-1348 MINT-7212378 MINT-7212356 MINT-7212320 I2D: score=1 STRING: ENSP00000337825
    NFKB1P198382, 3, ENSP000002265744MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544 I2D: score=5 STRING: ENSP00000226574
    NFKB2Q006532, 3, ENSP000001894444MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544 I2D: score=5 STRING: ENSP00000189444
    RELBQ012012, 3, ENSP000002214524MINT-6178520 MINT-6178488 MINT-6178544 I2D: score=1 STRING: ENSP00000221452
    FYNP062412, 3, ENSP000003576564MINT-7212338 I2D: score=4 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IMP16280327
    GO:0002268follicular dendritic cell differentiation IEA--
    GO:0002315marginal zone B cell differentiation IEA--
    GO:0002455humoral immune response mediated by circulating immunoglobulin IEA--
    GO:0002467germinal center formation IEA--

    Find genes that share ontologies with BCL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCL3

    3 Novoseek inferred chemical compound relationships for BCL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 54 6 16123212 (3), 16108830 (2)
    rapamycin 8.15 4 17110454 (2), 9576921 (1)
    tyrosine 0 7 16099425 (3), 9576921 (1)



    Find genes that share compounds with BCL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BCL3 gene: 
    NM_005178.4  

    Unigene Cluster for BCL3:

    B-cell CLL/lymphoma 3
    Hs.31210  [show with all ESTs]
    Unigene Representative Sequence: BC064993
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403534 ENST00000487394 ENST00000164227(uc010xxe.2) ENST00000444487
    ENST00000473468 ENST00000464319 ENST00000474300 ENST00000477832 ENST00000473473

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    hsa-miR-4324 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-19b
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    Additional mRNA sequence: 

    AK296180.1 AK309453.1 BC064993.1 M31732.1 

    6 DOTS entries:

    DT.313673  DT.121499920  DT.91651190  DT.91756691  DT.95169089  DT.91981506 

    Selected AceView cDNA sequences (see all 128):

    CA392190 BI084242 BM708626 CD678867 BQ669654 BM713016 BM918173 BM759970 
    BF001239 BQ670418 CA392189 BQ673686 BQ673772 AA293187 BU501187 BU145268 
    AI168170 BM676215 BC064993 BF590941 AI347138 AW364291 BQ893402 AI949568 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                                      -                       -                     
    SP2:                                      -                                             
    SP3:                                                              -                     
    SP4:                                                                                    


    ECgene alternative splicing isoforms for BCL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BCL3 Expression
    About this image


    BCL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    BCL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.31210
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL3: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BCL3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl31 , 5 B cell leukemia/lymphoma 31, 5 82.44(n)1
    82.37(a)1
      7 (9.95 cM)5
    120511  NM_033601.31  NP_291079.21 
     198084625 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    13(a)
    many ↔ many
    24(5515277-5527369)
    lizard
    (Anolis carolinensis)
    Reptilia BCL36
    B-cell CLL/lymphoma 3
    53(a)
    1 ↔ 1
    GL344711.1(5551-14148)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004896001 B-cell lymphoma 3 protein homolog 59.5(n)
    58.06(a)
      100489600  XM_002941035.2  XP_002941081.2 
    zebrafish
    (Danio rerio)
    Actinopterygii bcl36
    B-cell CLL/lymphoma 3
    32(a)
    1 ↔ 1
    16(27941266-27980506) ENSDARG00000087832


    ENSEMBL Gene Tree for BCL3 (if available)
    TreeFam Gene Tree for BCL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCL3 gene
    NFKBID2  NFKBIB2  NFKBIA2  NFKBIE2  NFKBIZ2  
    2 SIMAP similar genes for BCL3 using alignment to 2 protein entries:     BCL3_HUMAN (see all proteins):
    IkBa    NFKBIE

    Find genes that share paralogs with BCL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCL3 (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606024041,2
    C,F--45250038(+) GCCTCG/ACCCCT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1869405581,2
    --45250144(+) AACACA/CGCCCC 1 -- us2k10--------
    rs1502442761,2
    C--45250172(+) TTCCTC/TCCCTC 1 -- us2k10--------
    rs1458286871,2
    --45250192(+) TGTGGC/GCCCCA 1 -- us2k10--------
    rs124603881,2
    C,H--45250331(+) GTGCTC/TGGGAT 1 -- us2k14Minor allele frequency- T:0.10WA NA EA 360
    rs1131141981,2
    C,F--45250342(+) GTTTCG/ACCATG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs10790861,2
    C,F--45250364(+) GGGAGA/GTCCAG 1 -- us2k111Minor allele frequency- G:0.15EA NA MN WA CSA 364
    rs29651701,2
    C,F,A,H--45250508(-) CCCTGG/AGACCT 1 -- us2k1 tfbs316Minor allele frequency- A:0.21NS EA NA WA CSA 1312
    rs1926928891,2
    C--45250680(+) CCCCGC/GCCCCT 1 -- us2k10--------
    rs1850036991,2
    --45250793(+) TCGGGA/GCCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCL3 (45250962 - 45263301 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BCL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833841CNV Loss17160897
    nsv912116CNV Loss21882294
    nsv2506CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL3
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109560    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749
  • Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia
    (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions

  • 4 diseases for BCL3:    
    About MalaCards
    leukemia/lymphoma, b-cell, 3    mature b-cell neoplasm    leukemia    marginal zone b-cell lymphoma

    4 diseases from the University of Copenhagen DISEASES database for BCL3:
    Cleft lip     Lymphoma     Cleft palate     Leukemia

    Find genes that share disorders with BCL3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BCL3 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 75.2 15 15716244 (2), 2243504 (2), 8011990 (2), 17644518 (1) (see all 12)
    lymphocytic leukemia chronic b-cell 71.4 4 8336935 (1), 8011990 (1), 11713278 (1), 16533741 (1)
    lymphoma t-cell peripheral 57.4 2 15105810 (1), 16123212 (1)
    trisomy 53.9 2 9078289 (1), 15716244 (1)
    lymphoma b-cell 53.4 6 15105810 (1), 11672772 (1), 18052923 (1), 16384933 (1)
    lymphoma non-hodgkins 52.3 8 2243504 (2), 15105810 (1), 12835724 (1), 8011990 (1) (see all 6)
    lymphoid neoplasm 47.7 1 15105810 (1)
    anaplastic large cell lymphoma 47 3 16108830 (1), 12456498 (1), 16533741 (1)
    lymphoma follicular 45.8 6 8400234 (3), 15105810 (1), 1923524 (1)
    hodgkin disease 42.9 8 15105810 (3), 15716244 (1), 12456498 (1), 16533741 (1)

    Genatlas disease: BCL3
    B cell lymphoma with translocation t(14;19)(q32;q13.1)

    Genetic Association Database (GAD): BCL3
    Human Genome Epidemiology (HuGE) Navigator: BCL3 (13 documents)
    Tumor Gene Database (TGDB): BCL3

    Export disorders for BCL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCL3 gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with BCL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. (PubMed id 2180580)1, 2, 3, 9 Ohno H.... McKeithan T.W. (Cell 1990)
    2. GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. (PubMed id 15469820)1, 2, 9 Viatour P.... Chariot A. (Mol. Cell 2004)
    3. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. (PubMed id 11707390)1, 2, 9 Michel F....Muller C.W. (EMBO J. 2001)
    4. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. (PubMed id 8453667)1, 2, 9 Bours V....Siebenlist U. (Cell 1993)
    5. Genomic structure of the candidate proto-oncogene BCL3. (PubMed id 7896265)1, 2, 9 McKeithan T.W.... Hume E. (Genomics 1994)
    6. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (Eur. J. Oral Sci. 2010)
    7. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    8. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1, 4 Fransen K....Weersma R.K. (Hum. Mol. Genet. 2010)
    9. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    10. Differential parental transmission of markers in BCL3 among Korean cleft case-parent trios. (PubMed id 19229118)1, 4 Park B.Y....Beaty T.H. (J Prev Med Public Health 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 602 HGNC: 998 AceView: BCL3 Ensembl:ENSG00000069399 euGenes: HUgn602
    ECgene: BCL3 Kegg: 602 H-InvDB: BCL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BCL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCL3 gene:
    Search GeneIP for patents involving BCL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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