Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL3 Gene

protein-coding   GIFtS: 61
GCID: GC19P045250

B-Cell CLL/Lymphoma 3


(Previous symbols: D19S37, BCL4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 31 2     Chronic Lymphatic Leukemia Protein1 2
BCL41 2 3     Proto-Oncogene BCL32 3
D19S371 2 3     BCL-32 3
B-Cell Leukemia/Lymphoma 31 2     B-Cell Lymphoma 3 Protein2
B-Cell Lymphoma 3-Encoded Protein1 2     

External Ids:    HGNC: 9981   Entrez Gene: 6022   Ensembl: ENSG000000693997   OMIM: 1095605   UniProtKB: P207493   

Export aliases for BCL3 gene to outside databases

Previous GC identifers: GC19P045896 GC19P045642 GC19P049927 GC19P049943 GC19P041684


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL3 Gene:
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus
in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most
closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator
that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by
NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
(provided by RefSeq, Jul 2008)

GeneCards Summary for BCL3 Gene: 
BCL3 (B-cell CLL/lymphoma 3) is a protein-coding gene. Diseases associated with BCL3 include mature b-cell neoplasm, and translocation renal cell carcinoma, and among its related super-pathways are IL-9 Signaling Pathways and NF-KappaB (p50-p65) Pathway. GO annotations related to this gene include protein binding, bridging and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFKBID.

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749
Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the
cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as
transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation
of cell proliferation (By similarity)

Gene Wiki entry for BCL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL3 gene promoter:
         STAT5B   STAT1   Lmo2   Olf-1   AP-2gamma   NF-kappaB   C/EBPalpha   GATA-2   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.1-q13.2

BCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045250:  view genomic region     (about GC identifiers)

Start:
45,250,962 bp from pter      End:
45,263,301 bp from pter
Size:
12,340 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749 (See protein sequence)
Recommended Name: B-cell lymphoma 3 protein  
Size: 454 amino acids; 47584 Da
Subunit: Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex
consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD
(By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity).
Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation (By similarity)
Caution: It is uncertain whether Met-1 or Met-9 is the initiator
Sequence caution: Sequence=AAA51815.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA51816.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH64993.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for BCL3:
1K1A (3D)        1K1B (3D)    

Explore the universe of human proteins at neXtProt for BCL3: NX_P20749

Explore proteomics data for BCL3 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.
    Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents
    nuclear accumulation (By similarity)
  • UniProtKB: Activated by phosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20749

  • BCL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCL3 Protein Expression
    REFSEQ proteins: NP_005169.2  
    ENSEMBL proteins: 
     ENSP00000164227   ENSP00000393731  

    Human Recombinant Protein Products for BCL3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCL3
    OriGene Protein Over-expression Lysate for BCL3
    OriGene MassSpec for BCL3 
    OriGene Custom Protein Services for BCL3
    GenScript Custom Purified and Recombinant Proteins Services for BCL3
    Novus Biologicals BCL3 Protein
    Novus Biologicals BCL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16280327
    GO:0005737cytoplasm IDA11387332
    GO:0032996Bcl3-Bcl10 complex IDA16280327
    GO:0033257Bcl3/NF-kappaB2 complex IDA9407099
    GO:0043234protein complex IDA16280327

    BCL3 for ontologies           About GeneDecksing



    BCL3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for BCL3
    OriGene Custom Antibody Services for BCL3
    GenScript Custom Superior Antibodies Services for BCL3
    Novus Biologicals BCL3 Antibodies
    Abcam antibodies for BCL3
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for BCL3
    LSBio Antibodies in human, mouse, rat for BCL3 

    Assay Products for BCL3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCL3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCL3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry P20749

    ProtoNet protein and cluster: P20749

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749
    Similarity: Contains 7 ANK repeats


    BCL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL3_HUMAN, P20749
    Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the
    cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as
    transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation
    of cell proliferation (By similarity)

         Genatlas biochemistry entry for BCL3:
    inhibitor of REL/NFKB transcription factors,IKB (NFKBI) family

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10362352
    GO:0008134transcription factor binding IPI11387332
    GO:0030674protein binding, bridging TAS16306601
         
    BCL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL3:
     Increased cell number in S 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Bcl3):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    BCL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BCL3: Bcl3tm1Sbn Bcl3tm1Ver Bcl3tm1Rsch Bcl3tm1Rie

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL3
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL3 (see all 13):
    hsa-miR-4324 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidBCL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BCL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCL3
    Sirion Biotech Customized adenovirus for overexpression of BCL3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BCL3 (see all 8)
    OriGene ORF clones in mouse, rat for BCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCL3 (NM_005178)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL3
    Sirion Biotech Customized lentivirus for stable overexpression of BCL3 
                         Customized lentivirus expression plasmids for stable overexpression of BCL3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCL3
    Search LifeMap BioReagents cell lines for BCL3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    Immune response IL-9 signaling pathway0.42
    IL-9 Pathway0.36
    2NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    4Atypical NF-kappaB pathway
    Atypical NF-kappaB pathway
    5TNF signaling pathway
    TNF signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BCL3
        Immune response IL-9 signaling pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCL3
        IL-9 Pathway
    NF-KappaB Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for BCL3
        Immune response IL-9 signaling pathway

    2 BioSystems Pathways for BCL3
        TNF-alpha/NF-kB Signaling Pathway
    Atypical NF-kappaB pathway


    1         Kegg Pathway  (Kegg details for BCL3):
        TNF signaling pathway


    BCL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for BCL3 (P207491, 2, 3 ENSP000001642274) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198382, 3, ENSP000002265744MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544 I2D: score=5 STRING: ENSP00000226574
    NFKB2Q006532, 3, ENSP000001894444MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544 I2D: score=5 STRING: ENSP00000189444
    LCKP062392, 3, ENSP000003378254MINT-7212378 MINT-7212356 MINT-7212320 I2D: score=1 STRING: ENSP00000337825
    RELBQ012012, 3, ENSP000002214524MINT-6178520 MINT-6178488 MINT-6178544 I2D: score=1 STRING: ENSP00000221452
    FYNP062412, 3, ENSP000003576564MINT-7212338 I2D: score=4 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IMP16280327
    GO:0002268follicular dendritic cell differentiation IEA--
    GO:0002315marginal zone B cell differentiation IEA--
    GO:0002455humoral immune response mediated by circulating immunoglobulin IEA--
    GO:0002467germinal center formation IEA--

    BCL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCL3

    3 Novoseek inferred chemical compound relationships for BCL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 54 6 16123212 (3), 16108830 (2)
    rapamycin 8.15 4 17110454 (2), 9576921 (1)
    tyrosine 0 7 16099425 (3), 9576921 (1)

    Search CenterWatch for drugs/clinical trials and news about BCL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCL3 gene: 
    NM_005178.4  

    Unigene Cluster for BCL3:

    B-cell CLL/lymphoma 3
    Hs.31210  [show with all ESTs]
    Unigene Representative Sequence: BC064993
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403534 ENST00000487394 ENST00000164227(uc010xxe.2) ENST00000444487
    ENST00000473468 ENST00000464319 ENST00000474300 ENST00000477832 ENST00000473473

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL3
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL3 (see all 13):
    hsa-miR-4324 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-19b
    SwitchGear 3'UTR luciferase reporter plasmidBCL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BCL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL3
    Clone
    Products:
         
    OriGene clones in human, mouse for BCL3 (see all 8)
    OriGene ORF clones in mouse, rat for BCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCL3 (NM_005178)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL3
    Sirion Biotech Customized lentivirus for stable overexpression of BCL3 
                         Customized lentivirus expression plasmids for stable overexpression of BCL3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for BCL3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCL3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL3

    Additional mRNA sequence: 

    AK296180.1 AK309453.1 BC064993.1 M31732.1 

    6 DOTS entries:

    DT.313673  DT.121499920  DT.91651190  DT.91756691  DT.95169089  DT.91981506 

    24/128 AceView cDNA sequences (see all 128):

    BI084242 BM918173 BM713016 AA293187 BQ669654 BU145268 AI347138 BQ673686 
    CA392190 BF001239 CA392189 BQ673772 AI168170 BM676215 BM759970 BF590941 
    BU501187 BM708626 CD678867 BQ670418 BC064993 BQ941806 AI949568 AI743183 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                                      -                       -                     
    SP2:                                      -                                             
    SP3:                                                              -                     
    SP4:                                                                                    


    ECgene alternative splicing isoforms for BCL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BCL3 Expression
    About this image


    See BCL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL3

    SOURCE GeneReport for Unigene cluster: Hs.31210
        SABiosciences Expression via Pathway-Focused PCR Arrays including BCL3: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BCL3
    OriGene qSTAR qPCR primer pairs in human, mouse for BCL3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCL3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BCL3 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl31 , 5 B cell leukemia/lymphoma 31, 5 82.59(n)1
    82.59(a)1
      7 (9.95 cM)5
    120511  NM_033601.31  NP_291079.21 
     198084625 
    lizard
    (Anolis carolinensis)
    Reptilia BCL36
    Uncharacterized protein
    52(a)
    1 ↔ 1
    GL344711.1(5551-14148)
    zebrafish
    (Danio rerio)
    Actinopterygii bcl36
    B-cell CLL/lymphoma 3
    31(a)
    1 ↔ 1
    16(27941794-27978612)


    ENSEMBL Gene Tree for BCL3 (if available)
    TreeFam Gene Tree for BCL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCL3 gene
    NFKBID2  NFKBIB2  NFKBIA2  NFKBIE2  NFKBIZ2  
    2 SIMAP similar genes for BCL3 using alignment to 2 protein entries:     BCL3_HUMAN (see all proteins):
    IkBa    NFKBIE

    BCL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/324 SNPs in BCL3 are shown (see all 324)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606024041,2
    C,F--45250038(+) GCCTCG/ACCCCT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1869405581,2
    --45250144(+) AACACA/CGCCCC 1 -- us2k10--------
    rs1502442761,2
    C--45250172(+) TTCCTC/TCCCTC 1 -- us2k10--------
    rs1458286871,2
    --45250192(+) TGTGGC/GCCCCA 1 -- us2k10--------
    rs124603881,2
    C,H--45250331(+) GTGCTC/TGGGAT 1 -- us2k14Minor allele frequency- T:0.10WA NA EA 360
    rs1131141981,2
    C,F--45250342(+) GTTTCG/ACCATG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs10790861,2
    C,F--45250364(+) GGGAGA/GTCCAG 1 -- us2k111Minor allele frequency- G:0.15EA NA MN WA CSA 364
    rs29651701,2
    C,F,A,H--45250508(-) CCCTGG/AGACCT 1 -- us2k1 tfbs316Minor allele frequency- A:0.21NS EA NA WA CSA 1312
    rs1926928891,2
    C--45250680(+) CCCCGC/GCCCCT 1 -- us2k10--------
    rs1850036991,2
    --45250793(+) TCGGGA/GCCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCL3 (45250962 - 45263301 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BCL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833841CNV Loss17160897
    nsv912116CNV Loss21882294
    nsv2506CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL3
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109560    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749
  • Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia
    (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions

  • 20/34 diseases for BCL3 (see all 34):    About MalaCards
    mature b-cell neoplasm    translocation renal cell carcinoma    t-cell leukemia    b-cell lymphomas
    peripheral t-cell lymphoma    anaplastic large cell lymphoma    marginal zone b-cell lymphoma    orofacial cleft
    nasopharyngitis    leukemia    human t-cell leukemia virus type 1    cleft lip
    chronic lymphocytic leukemia    b-cell chronic lymphocytic leukemia    cleft palate    retinoblastoma
    chondrosarcoma    hodgkin's lymphoma    non-hodgkin lymphoma    crohn's disease

    4 diseases from the University of Copenhagen DISEASES database for BCL3:
    Cleft lip     Lymphoma     Cleft palate     Leukemia

    BCL3 for disorders           About GeneDecksing

    10/24 Novoseek inferred disease relationships for BCL3 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 75.2 15 15716244 (2), 2243504 (2), 8011990 (2), 17644518 (1) (see all 12)
    lymphocytic leukemia chronic b-cell 71.4 4 8336935 (1), 8011990 (1), 11713278 (1), 16533741 (1)
    lymphoma t-cell peripheral 57.4 2 15105810 (1), 16123212 (1)
    trisomy 53.9 2 9078289 (1), 15716244 (1)
    lymphoma b-cell 53.4 6 15105810 (1), 11672772 (1), 18052923 (1), 16384933 (1)
    lymphoma non-hodgkins 52.3 8 2243504 (2), 15105810 (1), 12835724 (1), 8011990 (1) (see all 6)
    lymphoid neoplasm 47.7 1 15105810 (1)
    anaplastic large cell lymphoma 47 3 16108830 (1), 12456498 (1), 16533741 (1)
    lymphoma follicular 45.8 6 8400234 (3), 15105810 (1), 1923524 (1)
    hodgkin disease 42.9 8 15105810 (3), 15716244 (1), 12456498 (1), 16533741 (1)

    Genatlas disease: BCL3
    B cell lymphoma with translocation t(14;19)(q32;q13.1)

    Genetic Association Database (GAD): BCL3
    Human Genome Epidemiology (HuGE) Navigator: BCL3 (13 documents)
    Tumor Gene Database (TGDB): BCL3

    Export disorders for BCL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL3 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with BCL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. (PubMed id 2180580)1, 2, 3, 9 Ohno H.... McKeithan T.W. (1990)
    2. GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. (PubMed id 15469820)1, 2, 9 Viatour P.... Chariot A. (2004)
    3. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. (PubMed id 11707390)1, 2, 9 Michel F....Muller C.W. (2001)
    4. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. (PubMed id 8453667)1, 2, 9 Bours V....Siebenlist U. (1993)
    5. Genomic structure of the candidate proto-oncogene BCL3. (PubMed id 7896265)1, 2, 9 McKeithan T.W.... Hume E. (1994)
    6. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (2010)
    7. Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (2010)
    8. Analysis of SNPs with an effect on gene expression id entifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1, 4 Fransen K....Weersma R.K. (2010)
    9. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    10. Differential parental transmission of markers in BCL3 among Korean cleft case-parent trios. (PubMed id 19229118)1, 4 Park B.Y....Beaty T.H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 602 HGNC: 998 AceView: BCL3 Ensembl:ENSG00000069399 euGenes: HUgn602
    ECgene: BCL3 Kegg: 602 H-InvDB: BCL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCL3 gene:
    Search GeneIP for patents involving BCL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL3
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BCL3   OriGene RNAi products in human, mouse, rat for BCL3  
     OriGene qPCR primer pairs and template standards for BCL3   OriGene Protein Over-expression Lysate for BCL3  
     OriGene MassSpec something-or-other for BCL3   OriGene clones in human, mouse for BCL3  
     OriGene qSTAR qPCR primer pairs in human, mouse for BCL3   OriGene Purified Protein for BCL3  
     OriGene ORF clones in mouse, rat for BCL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCL3   OriGene Custom Protein Services for BCL3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCL3
     QIAGEN SeqTarget long-range PCR primers for resequencing BCL3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL3
     GenScript Custom Purified and Recombinant Proteins Services for BCL3 GenScript cDNA clones with any tag delivered in your preferred vector for BCL3
     GenScript Custom Assay Services for BCL3 GenScript Custom Superior Antibodies Services for BCL3
     GenScript Custom overexpressing Cell Line Services for BCL3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BCL3 promoter
     Search Chromatin IP Primers for BCL3
     RT2 qPCR Primer Assay in human, mouse, rat BCL3
     GNC Network for BCL3
     SABiosciences PCR Arrays including human, mouse, rat BCL3
     Search Tocris compounds for BCL3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BCL3 antibodies
     BCL3 proteins
     BCL3 lysates
     Antibodies for BCL3
     See all of Abcam's Antibodies, Kits and Proteins for BCL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for BCL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL3
     SwitchGear 3'UTR luciferase reporter plasmids for BCL3
     SwitchGear Promoter luciferase reporter plasmids for BCL3
     ThermoFisher Antibody for BCL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BCL3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCL3
    Customized:
     lentivirus for stable overexpression of BCL3
     lentivirus expression plasmids for stable overexpression of BCL3
     adenovirus for overexpression of BCL3
     LSBio Antibodies in human, mouse, rat for BCL3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCL3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4