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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL3 Gene

protein-coding GIFtS: 61
GCID: GC19P045250

B-cell CLL/lymphoma 3

(Previous symbols: D19S37, BCL4)

Explore 36 diseases affiliated with
BCL3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 3¹ ²		B-Cell Leukemia/Lymphoma 3²
BCL4¹ ² ³		B-Cell Lymphoma 3 Protein²
D19S37¹ ² ³		B-Cell Lymphoma 3-Encoded Protein²
Proto-Oncogene BCL3² ³		Chronic Lymphatic Leukemia Protein²
BCL-3² ³

External Ids:	HGNC: 998¹	Entrez Gene: 602²	Ensembl: ENSG00000069399⁷	OMIM: 109560⁵	UniProtKB: P20749³

Export aliases for BCL3 gene to outside databases

Previous GC identifers: GC19P045896 GC19P045642 GC19P049927 GC19P049943 GC19P041684

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL3:

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in

some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely

related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates

through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which

forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749

Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm,

inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator

that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By

similarity)

Gene Wiki entry for BCL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL3 gene promoter:
STAT5B STAT1 Lmo2 Olf-1 AP-2gamma NF-kappaB C/EBPalpha GATA-2 STAT3 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BCL3 promoter sequence

Search SABiosciences Chromatin IP Primers for BCL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.1-q13.2

BCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P045250: view genomic region (about GC identifiers)

Start:	45,250,962 bp from pter	End:	45,263,301 bp from pter
Size:	12,340 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749 (See protein sequence)

Recommended Name: B-cell lymphoma 3 protein

Size: 454 amino acids; 47584 Da

Subunit: Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex

consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By

similarity)

Subcellular location: Nucleus. Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity).

Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation (By similarity)

Caution: It is uncertain whether Met-1 or Met-9 is the initiator

Sequence caution: Sequence=AAA51815.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAA51816.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH64993.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

2 PDB 3D structures from and Proteopedia for BCL3:

1K1A (3D)

1K1B (3D)

Explore the universe of human proteins at neXtProt for BCL3: NX_P20749

Post-translational modifications:

Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.

Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear

accumulation (By similarity)¹

Activated by phosphorylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20749

BCL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005169.2

ENSEMBL proteins:

ENSP00000164227 ENSP00000393731

Human Recombinant Protein Products for BCL3:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	8196632
GO:0005737	cytoplasm	IDA	11387332
GO:0032996	Bcl3-Bcl10 complex	IDA	16280327
GO:0033257	Bcl3/NF-kappaB2 complex	IDA	9407099
GO:0043234	protein complex	IDA	16280327

BCL3 for ontologies About GeneDecksing

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Assay Products for BCL3:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCL3 for domains About GeneDecksing

2 InterPro domains/families:

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry P20749

ProtoNet protein and cluster: P20749

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749

Similarity: Contains 7 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: BCL3_HUMAN, P20749

Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm,

inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator

that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By

inhibitor of REL/NFKB transcription factors,IKB (NFKBI) family

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008134	transcription factor binding	IPI	16306601
GO:0030674	protein binding, bridging	TAS	16306601

BCL3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for BCL3:

Increased cell number in S

5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Bcl3):

cellular

hematopoietic system

homeostasis/metabolism

immune system

mortality/aging

BCL3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for BCL3: Bcl3^tm1Sbn Bcl3^tm1Ver Bcl3^tm1Rsch Bcl3^tm1Rie

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BCL3

miRNA Products:		OriGene 3'-UTR Clone: BCL3 Browse MicroRNA Expression Plasmids
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		hsa-miR-4324 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-19b

		SwitchGear 3'UTR luciferase reporter plasmid: BCL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IL-9 Signaling Pathways

	Immune response_IL-9 signaling pathway	0.42			IL-9 Pathway	0.22
	Immune response IL-9 signaling pathway	0.42

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

Atypical NF-kappaB pathway

Atypical NF-kappaB pathway

1.00

NF-KappaB Family Pathway

NF-KappaB Family Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for BCL3

Immune response IL-9 signaling pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCL3

	IL-9 Pathway
	NF-KappaB Family Pathway

1 GeneGo (Thomson Reuters) Pathway for BCL3

Immune response IL-9 signaling pathway

2 BioSystems Pathways for BCL3

	TNF-alpha/NF-kB Signaling Pathway
	Atypical NF-kappaB pathway

BCL3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BCL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for BCL3 (P20749^{1, 2, 3} ENSP00000164227⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838²^,³, ENSP00000226574⁴	MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544 I2D: score=5 STRING: ENSP00000226574
NFKB2	Q00653²^,³, ENSP00000189444⁴	MINT-6178467 MINT-6178520 MINT-6178504 MINT-6178488 MINT-6178544 I2D: score=5 STRING: ENSP00000189444
LCK	P06239²^,³, ENSP00000337825⁴	MINT-7212378 MINT-7212356 MINT-7212320 I2D: score=1 STRING: ENSP00000337825
RELB	Q01201²^,³, ENSP00000221452⁴	MINT-6178520 MINT-6178488 MINT-6178544 I2D: score=1 STRING: ENSP00000221452
FYN	P06241²^,³, ENSP00000357656⁴	MINT-7212338 I2D: score=4 STRING: ENSP00000357656

About this table

Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IMP	16280327
GO:0002268	follicular dendritic cell differentiation	IEA	--
GO:0002315	marginal zone B cell differentiation	IEA	--
GO:0002455	humoral immune response mediated by circulating immunoglobulin	IEA	--
GO:0002467	germinal center formation	IEA	--

BCL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BCL3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BCL3
3 Novoseek chemical compound relationships for BCL3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]	54	6	16123212 (3), 16108830 (2)
rapamycin	8.15	4	17110454 (2), 9576921 (1)
tyrosine	0	7	16099425 (3), 9576921 (1)

Search CenterWatch for drugs/clinical trials and news about BCL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BCL3 gene:

NM_005178.4

Unigene Cluster for BCL3:

B-cell CLL/lymphoma 3

Hs.31210 [show with all ESTs]

Unigene Representative Sequence: BC064993

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000403534 ENST00000487394 ENST00000164227(uc010xxe.2) ENST00000444487

ENST00000473468 ENST00000464319 ENST00000474300 ENST00000477832 ENST00000473473

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		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL3 (see all 13):
		hsa-miR-4324 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-324-3p hsa-miR-128 hsa-miR-3681* hsa-miR-19b

		SwitchGear 3'UTR luciferase reporter plasmid: BCL3 3' UTR sequence

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Additional cDNA sequence:

AK296180.1 AK309453.1 BC064993.1 M31732.1

6 DOTS entries:

DT.313673 DT.121499920 DT.91651190 DT.91756691 DT.95169089 DT.91981506

24/128 AceView cDNA sequences (see all 128):

AI168170 BF590941 BM676215 BU145268 CA392189 BQ670418 AA293187 BI084242

BM759970 BQ673772 BF001239 BC064993 CD678867 BM708626 AI347138 CA392190

BU501187 BQ669654 BM918173 BM713016 BQ673686 CB528691 BQ893402 AI498131

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for BCL3 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b
SP1:													-								-
SP2:													-
SP3:																					-
SP4:

ECgene alternative splicing isoforms for BCL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See BCL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL3

SOURCE GeneReport for Unigene cluster: Hs.31210
SABiosciences Expression via Pathway-Focused PCR Arrays including BCL3:

NFKB Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BCL3 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bcl3^{1 , 5}	B cell leukemia/lymphoma 3^{1, 5}	82.59(n)¹ 82.59(a)¹		7 (9.95 cM)⁵ 12051¹ NM_033601.3¹ NP_291079.2¹ 19808462⁵
lizard (Anolis carolinensis)	Reptilia	BCL3⁶	--	56(a)	1 ↔ 1	GL344711.1(6454-14148)
zebrafish (Danio rerio)	Actinopterygii	bcl3⁶	B-cell CLL/lymphoma 3	29(a)	1 ↔ 1	16(27941794-27978612)

ENSEMBL Gene Tree for BCL3 (if available)
TreeFam Gene Tree for BCL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BCL3 gene

NFKBID² NFKBIA² NFKBIB² NFKBIE² NFKBIZ²

2 SIMAP similar genes for BCL3 using alignment to 2 protein entries: BCL3_HUMAN (see all proteins):

IkBa NFKBIE

BCL3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60602404^1,2		--	45250038(+)	`GCCTCG/ACCCCT`	1	--	us2k¹		2		CSA WA	120
rs186940558^1,2		--	45250144(+)	`AACACA/CGCCCC`	1	--	us2k¹		0	--	--	--	--
rs150244276^1,2		--	45250172(+)	`TTCCTC/TCCCTC`	1	--	us2k¹		0	--	--	--	--
rs145828687^1,2		--	45250192(+)	`TGTGGC/GCCCCA`	1	--	us2k¹		0	--	--	--	--
rs12460388^1,2	C,H	--	45250331(+)	`GTGCTC/TGGGAT`	1	--	us2k¹		4		WA NA EA	360
rs113114198^1,2		--	45250342(+)	`GTTTCG/ACCATG`	1	--	us2k¹		1		CSA	2
rs1079086^1,2	C,F	--	45250364(+)	`GGGAGA/GTCCAG`	1	--	us2k¹		11		EA NA MN WA CSA	364
rs2965170^1,2	C,F,A,H	--	45250508(-)	`CCCTGG/AGACCT`	1	--	us2k¹ tfbs³		16		NS EA NA WA CSA	1312
rs192692889^1,2		--	45250680(+)	`CCCCGC/GCCCCT`	1	--	us2k¹		0	--	--	--	--
rs185003699^1,2		--	45250793(+)	`TCGGGA/GCCCCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BCL3 (45250962 - 45263301 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BCL3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BCL3 for disorders About GeneDecksing

OMIM gene information: 109560 OMIM disorders: --

UniProtKB/Swiss-Prot: BCL3_HUMAN, P20749

Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL).

Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions

20/36 diseases for BCL3 (see all 36): About MalaCards

b-cell lymphomas leukemia/lymphoma t-cell leukemia leukemia

leukemia/lymphoma, b-cell, 3 marginal zone b-cell lymphoma mature b-cell neoplasm anaplastic large cell lymphoma

human t-cell leukemia virus type 1 cleft lip/palate cleft lip non-hodgkin lymphoma

orofacial cleft lymphocytic leukemia peripheral t-cell lymphoma cleft palate

hodgkin's lymphoma chronic lymphocytic leukemia myeloproliferative disorder renal cell carcinoma

4 diseases from the University of Copenhagen DISEASES database for BCL3:

Cleft lip Chronic lymphocytic leukemia Lymphoma Cleft palate

10/24 Novoseek disease relationships for BCL3 gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia lymphocytic chronic	75.2	15	15716244 (2), 2243504 (2), 8011990 (2), 17644518 (1) (see all 12)
lymphocytic leukemia chronic b-cell	71.4	4	8336935 (1), 8011990 (1), 11713278 (1), 16533741 (1)
lymphoma t-cell peripheral	57.4	2	15105810 (1), 16123212 (1)
trisomy	53.9	2	9078289 (1), 15716244 (1)
lymphoma b-cell	53.4	6	15105810 (1), 11672772 (1), 18052923 (1), 16384933 (1)
lymphoma non-hodgkins	52.3	8	2243504 (2), 15105810 (1), 12835724 (1), 8011990 (1) (see all 6)
lymphoid neoplasm	47.7	1	15105810 (1)
anaplastic large cell lymphoma	47	3	16108830 (1), 12456498 (1), 16533741 (1)
lymphoma follicular	45.8	6	8400234 (3), 15105810 (1), 1923524 (1)
hodgkin disease	42.9	8	15105810 (3), 15716244 (1), 12456498 (1), 16533741 (1)

Genatlas disease: BCL3

B cell lymphoma with translocation t(14;19)(q32;q13.1)

Genetic Association Database (GAD): BCL3
Human Genome Epidemiology (HuGE) Navigator: BCL3 (13 documents)
Tumor Gene Database (TGDB): BCL3

Export disorders for BCL3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BCL3 gene, integrated from 9 sources (see all 143):
(articles sorted by number of sources associating them with BCL3)

Utopia: connect your pdf to the dynamic
world of online information

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. (PubMed id 2180580)^{1, 2, 3, 9} Ohno H.... McKeithan T.W. (1990)
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. (PubMed id 15469820)^{1, 2, 9} Viatour P.... Chariot A. (2004)
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. (PubMed id 11707390)^{1, 2, 9} Michel F....Muller C.W. (2001)
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. (PubMed id 8453667)^{1, 2, 9} Bours V....Siebenlist U. (1993)
Genomic structure of the candidate proto-oncogene BCL3. (PubMed id 7896265)^{1, 2, 9} McKeithan T.W.... Hume E. (1994)
[Possible association due to linkage disequilibrium of TGFA, RARA and BCL3 with nonsyndromic cleft lip with or without cleft palate in the Chilean population] (PubMed id 16311697)^{1, 4} Suazo J....Blanco R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. (PubMed id 12730195)^{1, 2} Watanabe N.... Fujita T. (2003)
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. (PubMed id 10362352)^{1, 2} Dechend R.... Leutz A. (1999)
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. (PubMed id 10469655)^{1, 2} Heissmeyer V.... Scheidereit C. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 602	HGNC: 998	AceView: BCL3	Ensembl:ENSG00000069399	euGenes: HUgn602
ECgene: BCL3	H-InvDB: BCL3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BCL3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BCL3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BCL3 gene
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Patent Information for BCL3 gene:
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