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Aliases for BCL2L2-PABPN1 Gene

Aliases for BCL2L2-PABPN1 Gene

  • BCL2L2-PABPN1 Readthrough 2 3
  • Apoptosis Regulator Bcl-W 4
  • BCL2-L-2 4
  • KIAA0271 4
  • BCL2L2 4
  • BCLW 4

External Ids for BCL2L2-PABPN1 Gene

Previous GeneCards Identifiers for BCL2L2-PABPN1 Gene

  • GC14U901221
  • GC14P023777
  • GC14P023792

Summaries for BCL2L2-PABPN1 Gene

Entrez Gene Summary for BCL2L2-PABPN1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]

GeneCards Summary for BCL2L2-PABPN1 Gene

BCL2L2-PABPN1 (BCL2L2-PABPN1 Readthrough) is a Protein Coding gene. Among its related pathways are Influenza A and mRNA surveillance pathway. An important paralog of this gene is PABPN1.

UniProtKB/Swiss-Prot for BCL2L2-PABPN1 Gene

  • Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L2-PABPN1 Gene

Genomics for BCL2L2-PABPN1 Gene

Genomic Location for BCL2L2-PABPN1 Gene

23,306,762 bp from pter
23,326,185 bp from pter
19,424 bases
Plus strand

Genomic View for BCL2L2-PABPN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL2L2-PABPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L2-PABPN1 Gene

No data available for Regulatory Elements for BCL2L2-PABPN1 Gene

Proteins for BCL2L2-PABPN1 Gene

  • Protein details for BCL2L2-PABPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K0F4
    • Q2M3U0
    • Q5U0H4

    Protein attributes for BCL2L2-PABPN1 Gene

    193 amino acids
    Molecular mass:
    20746 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    • Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L2-PABPN1 Gene

    Alternative splice isoforms for BCL2L2-PABPN1 Gene


neXtProt entry for BCL2L2-PABPN1 Gene

Proteomics data for BCL2L2-PABPN1 Gene at MOPED

Protein Expression for BCL2L2-PABPN1 Gene

Post-translational modifications for BCL2L2-PABPN1 Gene

  • Ubiquitination at Lys164, Lys234, and Lys250
  • Modification sites at PhosphoSitePlus

Other Protein References for BCL2L2-PABPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL2L2-PABPN1 Gene

Domains for BCL2L2-PABPN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q92843
  • The BH4 motif seems to be involved in the anti-apoptotic function
  • The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L2-PABPN1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BCL2L2-PABPN1 Gene

Function for BCL2L2-PABPN1 Gene

Molecular function for BCL2L2-PABPN1 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Gene Ontology (GO) - Molecular Function for BCL2L2-PABPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity --
GO:0046982 protein heterodimerization activity --
genes like me logo Genes that share ontologies with BCL2L2-PABPN1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BCL2L2-PABPN1 Gene

Localization for BCL2L2-PABPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L2-PABPN1 Gene

Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Gene Ontology (GO) - Cellular Components for BCL2L2-PABPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane --
GO:0070062 extracellular exosome --
genes like me logo Genes that share ontologies with BCL2L2-PABPN1: view

No data available for Subcellular locations from COMPARTMENTS for BCL2L2-PABPN1 Gene

Pathways for BCL2L2-PABPN1 Gene

SuperPathways for BCL2L2-PABPN1 Gene

genes like me logo Genes that share pathways with BCL2L2-PABPN1: view

Pathways by source for BCL2L2-PABPN1 Gene

2 KEGG pathways for BCL2L2-PABPN1 Gene

Gene Ontology (GO) - Biological Process for BCL2L2-PABPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage --
GO:0042981 regulation of apoptotic process --
GO:0043066 negative regulation of apoptotic process --
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand --
genes like me logo Genes that share ontologies with BCL2L2-PABPN1: view

Transcripts for BCL2L2-PABPN1 Gene

mRNA/cDNA for BCL2L2-PABPN1 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L2-PABPN1 Gene

No ASD Table

Relevant External Links for BCL2L2-PABPN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L2-PABPN1 Gene

mRNA expression in normal human tissues for BCL2L2-PABPN1 Gene

Protein differential expression in normal tissues for BCL2L2-PABPN1 Gene

This gene is overexpressed in Bone (13.8) and Frontal cortex (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL2L2-PABPN1 Gene

mRNA Expression by UniProt/SwissProt for BCL2L2-PABPN1 Gene

Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
genes like me logo Genes that share expressions with BCL2L2-PABPN1: view

Expression partners for BCL2L2-PABPN1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCL2L2-PABPN1 Gene

Orthologs for BCL2L2-PABPN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BCL2L2-PABPN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
(Mus musculus)
Mammalia Gm20521 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
(Danio rerio)
Actinopterygii pabpn1 35
  • 69.14 (n)
  • 74.54 (a)
pabpn1 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pabp2 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea pabp-2 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGN1 36
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PABN1 35
  • 58.09 (n)
  • 57.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1647 36
  • 67 (a)
Species with no ortholog for BCL2L2-PABPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BCL2L2-PABPN1 Gene

Gene Tree for BCL2L2-PABPN1 (if available)
Gene Tree for BCL2L2-PABPN1 (if available)

Paralogs for BCL2L2-PABPN1 Gene

Paralogs for BCL2L2-PABPN1 Gene

Selected SIMAP similar genes for BCL2L2-PABPN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BCL2L2-PABPN1: view

Variants for BCL2L2-PABPN1 Gene

Sequence variations from dbSNP and Humsavar for BCL2L2-PABPN1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7142474 -- 23,316,396(+) AGGCA(A/G)GATAA intron-variant
rs7148554 -- 23,316,742(+) gcgca(C/T)gccac intron-variant
rs7148851 -- 23,316,873(+) acagg(C/T)atgag intron-variant
rs8009057 -- 23,312,748(+) GTTAA(A/G)TTGCA intron-variant
rs9323298 -- 23,313,560(+) GATGA(A/G)CCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L2-PABPN1 Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Relevant External Links for BCL2L2-PABPN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L2-PABPN1 Gene

Disorders for BCL2L2-PABPN1 Gene

No disorders were found for BCL2L2-PABPN1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for BCL2L2-PABPN1 Gene

Publications for BCL2L2-PABPN1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for BCL2L2-PABPN1 Gene

Sources for BCL2L2-PABPN1 Gene

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