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Aliases for BCL2L2-PABPN1 Gene

Aliases for BCL2L2-PABPN1 Gene

  • BCL2L2-PABPN1 Readthrough 2 3 5
  • Apoptosis Regulator Bcl-W 4
  • Bcl2-L-2 4
  • KIAA0271 4
  • BCL2L2 4
  • BCLW 4

External Ids for BCL2L2-PABPN1 Gene

Previous GeneCards Identifiers for BCL2L2-PABPN1 Gene

  • GC14U901221
  • GC14P023777
  • GC14P023792
  • GC14P023457
  • GC14P023562
  • GC14P023676
  • GC14P023798
  • GC14P023888
  • GC14P023947

Summaries for BCL2L2-PABPN1 Gene

Entrez Gene Summary for BCL2L2-PABPN1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]

GeneCards Summary for BCL2L2-PABPN1 Gene

BCL2L2-PABPN1 (BCL2L2-PABPN1 Readthrough) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Influenza A. GO annotations related to this gene include nucleic acid binding and protein heterodimerization activity. An important paralog of this gene is PABPN1.

UniProtKB/Swiss-Prot for BCL2L2-PABPN1 Gene

  • Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Additional gene information for BCL2L2-PABPN1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L2-PABPN1 Gene

Genomics for BCL2L2-PABPN1 Gene

Regulatory Elements for BCL2L2-PABPN1 Gene

Enhancers for BCL2L2-PABPN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H022927 1.4 ENCODE dbSUPER 20.4 -377.2 -377155 3 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC MEF2D SSRP1 NGDN HAUS4 PRMT5 ACIN1 SLC7A8 PABPN1 SLC22A17 LOC102724814 BCL2L2-PABPN1 PPP1R3E
GH14H022976 1.9 FANTOM5 ENCODE dbSUPER 10 -326.9 -326857 7 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ACIN1 NGDN PRMT5 RBM23 C14orf93 HAUS4 MMP14 LOC102724814 PABPN1 SLC22A17
GH14H023284 1.4 ENCODE dbSUPER 12.4 -21.0 -21012 3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ACIN1 PRMT5 IPO4 HOMEZ RNF31 NGDN THTPA TSSK4 RABGGTA RNA5SP383
GH14H024270 1.5 FANTOM5 ENCODE 10.8 +966.1 966064 5 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 IPO4 TSSK4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1 TINF2 LTB4R
GH14H023093 1.4 ENCODE dbSUPER 10.9 -211.5 -211497 3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ACIN1 RBM23 NGDN BCL2L2-PABPN1 PRMT5 OXA1L C14orf119 HOMEZ LRP10 LOC102724814
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCL2L2-PABPN1 on UCSC Golden Path with GeneCards custom track

Promoters for BCL2L2-PABPN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066725 238 1201 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for BCL2L2-PABPN1 Gene

Chromosome:
14
Start:
23,306,762 bp from pter
End:
23,326,185 bp from pter
Size:
19,424 bases
Orientation:
Plus strand

Genomic View for BCL2L2-PABPN1 Gene

Genes around BCL2L2-PABPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L2-PABPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L2-PABPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L2-PABPN1 Gene

Proteins for BCL2L2-PABPN1 Gene

  • Protein details for BCL2L2-PABPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92843-B2CL2_HUMAN
    Recommended name:
    Bcl-2-like protein 2
    Protein Accession:
    Q92843
    Secondary Accessions:
    • A8K0F4
    • Q2M3U0
    • Q5U0H4

    Protein attributes for BCL2L2-PABPN1 Gene

    Size:
    193 amino acids
    Molecular mass:
    20746 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    SequenceCaution:
    • Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L2-PABPN1 Gene

    Alternative splice isoforms for BCL2L2-PABPN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2L2-PABPN1 Gene

Protein Expression for BCL2L2-PABPN1 Gene

Post-translational modifications for BCL2L2-PABPN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL2L2-PABPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL2L2-PABPN1 Gene

Domains & Families for BCL2L2-PABPN1 Gene

Gene Families for BCL2L2-PABPN1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

Q92843

UniProtKB/Swiss-Prot:

B2CL2_HUMAN :
  • The BH4 motif seems to be involved in the anti-apoptotic function.
  • Belongs to the Bcl-2 family.
Domain:
  • The BH4 motif seems to be involved in the anti-apoptotic function.
  • The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L2-PABPN1: view

No data available for Suggested Antigen Peptide Sequences for BCL2L2-PABPN1 Gene

Function for BCL2L2-PABPN1 Gene

Molecular function for BCL2L2-PABPN1 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Phenotypes From GWAS Catalog for BCL2L2-PABPN1 Gene

Gene Ontology (GO) - Molecular Function for BCL2L2-PABPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IBA --
GO:0097718 disordered domain specific binding IPI --
genes like me logo Genes that share ontologies with BCL2L2-PABPN1: view

Phenotypes for BCL2L2-PABPN1 Gene

genes like me logo Genes that share phenotypes with BCL2L2-PABPN1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for BCL2L2-PABPN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L2-PABPN1 Gene

Localization for BCL2L2-PABPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L2-PABPN1 Gene

Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L2-PABPN1 gene
Compartment Confidence
extracellular 5
mitochondrion 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for BCL2L2-PABPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IBA --
GO:0016020 membrane IEA --
GO:0031966 mitochondrial membrane IEA --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with BCL2L2-PABPN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BCL2L2-PABPN1 Gene

Pathways & Interactions for BCL2L2-PABPN1 Gene

SuperPathways for BCL2L2-PABPN1 Gene

genes like me logo Genes that share pathways with BCL2L2-PABPN1: view

Pathways by source for BCL2L2-PABPN1 Gene

2 KEGG pathways for BCL2L2-PABPN1 Gene

Gene Ontology (GO) - Biological Process for BCL2L2-PABPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007283 spermatogenesis TAS --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0042981 regulation of apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with BCL2L2-PABPN1: view

No data available for SIGNOR curated interactions for BCL2L2-PABPN1 Gene

Drugs & Compounds for BCL2L2-PABPN1 Gene

No Compound Related Data Available

Transcripts for BCL2L2-PABPN1 Gene

mRNA/cDNA for BCL2L2-PABPN1 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for BCL2L2-PABPN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L2-PABPN1 Gene

No ASD Table

Relevant External Links for BCL2L2-PABPN1 Gene

GeneLoc Exon Structure for
BCL2L2-PABPN1
ECgene alternative splicing isoforms for
BCL2L2-PABPN1

Expression for BCL2L2-PABPN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L2-PABPN1 Gene

Protein differential expression in normal tissues from HIPED for BCL2L2-PABPN1 Gene

This gene is overexpressed in Bone (13.8) and Frontal cortex (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2L2-PABPN1 Gene



Protein tissue co-expression partners for BCL2L2-PABPN1 Gene

mRNA Expression by UniProt/SwissProt for BCL2L2-PABPN1 Gene:

Q92843-B2CL2_HUMAN
Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.

Evidence on tissue expression from TISSUES for BCL2L2-PABPN1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with BCL2L2-PABPN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L2-PABPN1 Gene

Orthologs for BCL2L2-PABPN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BCL2L2-PABPN1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm20521 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pabpn1 33 34
  • 69.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pabp2 34
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pabp-2 34
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGN1 34
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PABN1 33
  • 58.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1647 34
  • 67 (a)
OneToMany
Species where no ortholog for BCL2L2-PABPN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BCL2L2-PABPN1 Gene

ENSEMBL:
Gene Tree for BCL2L2-PABPN1 (if available)
TreeFam:
Gene Tree for BCL2L2-PABPN1 (if available)

Paralogs for BCL2L2-PABPN1 Gene

Paralogs for BCL2L2-PABPN1 Gene

(5) SIMAP similar genes for BCL2L2-PABPN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BCL2L2-PABPN1: view

Variants for BCL2L2-PABPN1 Gene

Sequence variations from dbSNP and Humsavar for BCL2L2-PABPN1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs104894466 Pathogenic 23,321,504(+) AGCGG(C/G)GGCTG intron-variant, reference, missense
rs886041261 Pathogenic 23,321,492(+) GCGGC(-/GGCGGC/GGCGGCGGC)AGCAG intron-variant, cds-indel
rs794727719 Uncertain significance 23,323,984(+) AGTTC(C/T)CAGAC reference, missense
rs886042198 Uncertain significance 23,321,638(+) TGGAG(C/T)CTGAG intron-variant, reference, missense
rs886043674 Uncertain significance 23,321,521(+) GTCGG(G/T)GCTCC intron-variant, reference, missense

Variation tolerance for BCL2L2-PABPN1 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L2-PABPN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL2L2-PABPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCL2L2-PABPN1 Gene

Disorders for BCL2L2-PABPN1 Gene

Relevant External Links for BCL2L2-PABPN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L2-PABPN1

No disorders were found for BCL2L2-PABPN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L2-PABPN1 Gene

Publications for BCL2L2-PABPN1 Gene

  1. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A … Comb MJ (Molecular & cellular proteomics : MCP 2014) 4 60
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 60
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 60

Products for BCL2L2-PABPN1 Gene

Sources for BCL2L2-PABPN1 Gene

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