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Aliases for BCL2L2 Gene

Aliases for BCL2L2 Gene

  • BCL2-Like 2 2 3
  • BCLW 3 4 6
  • BCL2-L-2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 51 3
  • Apoptosis Regulator BCL-W 3
  • Apoptosis Regulator Bcl-W 4
  • Protein Phosphatase 1 2
  • Regulatory Subunit 51 2
  • Bcl-2-Like Protein 2 3
  • KIAA0271 4
  • PPP1R51 3
  • BCL-W 3

External Ids for BCL2L2 Gene

Summaries for BCL2L2 Gene

Entrez Gene Summary for BCL2L2 Gene

  • This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for BCL2L2 Gene

BCL2L2 (BCL2-Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include severe acute respiratory syndrome. Among its related pathways are MicroRNAs in cancer and Direct p53 effectors. An important paralog of this gene is BAK1.

UniProtKB/Swiss-Prot for BCL2L2 Gene

  • Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Gene Wiki entry for BCL2L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L2 Gene

Genomics for BCL2L2 Gene

Genomic Location for BCL2L2 Gene

23,298,790 bp from pter
23,311,759 bp from pter
12,970 bases
Plus strand

Genomic View for BCL2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L2 Gene

Regulatory Elements for BCL2L2 Gene

Proteins for BCL2L2 Gene

  • Protein details for BCL2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K0F4
    • Q2M3U0
    • Q5U0H4

    Protein attributes for BCL2L2 Gene

    193 amino acids
    Molecular mass:
    20746 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    • Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L2 Gene

    Alternative splice isoforms for BCL2L2 Gene


neXtProt entry for BCL2L2 Gene

Proteomics data for BCL2L2 Gene at MOPED

Post-translational modifications for BCL2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys164, Lys234, and Lys250

Other Protein References for BCL2L2 Gene

No data available for DME Specific Peptides for BCL2L2 Gene

Domains for BCL2L2 Gene

Gene Families for BCL2L2 Gene

  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits


  • The BH4 motif seems to be involved in the anti-apoptotic function:
    • Q92843
  • The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2:
    • Q92843
  • Belongs to the Bcl-2 family.:
    • Q92843
genes like me logo Genes that share domains with BCL2L2: view

Function for BCL2L2 Gene

Molecular function for BCL2L2 Gene

GENATLAS Biochemistry: BCL2-like 2,antiapoptotic,expressed in lymphoid and myeloid cells
UniProtKB/Swiss-Prot Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Gene Ontology (GO) - Molecular Function for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15694340
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IBA --
GO:0051400 BH domain binding IEA --
genes like me logo Genes that share ontologies with BCL2L2: view
genes like me logo Genes that share phenotypes with BCL2L2: view

Animal Models for BCL2L2 Gene

MGI Knock Outs for BCL2L2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL2L2 Gene

Localization for BCL2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L2 Gene

Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Subcellular locations from

Jensen Localization Image for BCL2L2 Gene COMPARTMENTS Subcellular localization image for BCL2L2 gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IBA --
GO:0005829 cytosol IEA --
GO:0031966 mitochondrial membrane --
genes like me logo Genes that share ontologies with BCL2L2: view

Pathways for BCL2L2 Gene

genes like me logo Genes that share pathways with BCL2L2: view

Pathways by source for BCL2L2 Gene

1 Sino Biological pathway for BCL2L2 Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for BCL2L2 Gene
1 Cell Signaling Technology pathway for BCL2L2 Gene
3 BioSystems pathways for BCL2L2 Gene
1 KEGG pathway for BCL2L2 Gene

Gene Ontology (GO) - Biological Process for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0007283 spermatogenesis TAS 8761287
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0042981 regulation of apoptotic process --
GO:0043066 negative regulation of apoptotic process IMP 17289999
genes like me logo Genes that share ontologies with BCL2L2: view

Compounds for BCL2L2 Gene

(19) ApexBio Compounds for BCL2L2 Gene

Compound Action Cas Number
2,3-DCPE hydrochloride Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. [418788-90-6]
ABT-199 Selective Bcl-2 inhibitor [1257044-40-8]
ABT-263 (Navitoclax) orally sellecitive inhibitor of Bcl-2 family proteins [923564-51-6]
ABT-737 novel and potent inhibitor of BCL-2 family proteins [852808-04-9]
Apogossypolone (ApoG2) pan Bcl-2 inhibitor [886578-07-0]
AT-101 R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 [90141-22-3]
Bax channel blocker Potent inhibitor of Bax-mediated mitochondrial cytochrome c release. [335165-68-9]
Bax inhibitor peptide P5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-83-4]
Bax inhibitor peptide V5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-81-2]
Bax inhibitor peptide, negative control Negative control peptide for the Bax inhibitor peptides V5 and P5 [1315378-74-5]
BM-1074 potent and efficacious Bcl-2/Bcl-xL inhibitor [1391108-10-3]
Gambogic Acid activates caspases with EC50 of 0.78-1.64 uM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 [2752-65-0]
HA14-1 non-peptidic ligand of a Bcl-2 [65673-63-4]
Marinopyrrole A novel and specific Mcl-1 inhibitor [1227962-62-0]
MIM1 Inhibitor of Mcl-1
Obatoclax mesylate (GX15-070) potently inhibits BCL-2 family [803712-79-0]
Sabutoclax pan-Bcl-2 inhibitor [1228108-65-3]
TW-37 potent small-molecule inhibitor of BCL-2 [877877-35-5]
WEHI-539 high affinity (subnanomolar) and selectivity for BCL-XL [1431866-33-9]

(1) Novoseek inferred chemical compound relationships for BCL2L2 Gene

Compound -log(P) Hits PubMed IDs
cisplatin 24.3 1
genes like me logo Genes that share compounds with BCL2L2: view

Transcripts for BCL2L2 Gene

Unigene Clusters for BCL2L2 Gene

BCL2-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for BCL2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L2 Gene

mRNA expression in normal human tissues for BCL2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL2L2 Gene

SOURCE GeneReport for Unigene cluster for BCL2L2 Gene Hs.410026

mRNA Expression by UniProt/SwissProt for BCL2L2 Gene

Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
genes like me logo Genes that share expressions with BCL2L2: view

Orthologs for BCL2L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCL2L2 36
  • 99.83 (n)
  • 100 (a)
BCL2L2 37
  • 99 (a)
(Bos Taurus)
Mammalia BCL2L2 36
  • 95.85 (n)
  • 100 (a)
BCL2L2 37
  • 99 (a)
(Canis familiaris)
Mammalia BCL2L2 36
  • 94.82 (n)
  • 100 (a)
BCL2L2 37
  • 99 (a)
(Mus musculus)
Mammalia Bcl2l2 36
  • 93.78 (n)
  • 98.96 (a)
Bcl2l2 16
Bcl2l2 37
  • 98 (a)
(Monodelphis domestica)
Mammalia BCL2L2 37
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia BCL2L2 37
  • 73 (a)
(Rattus norvegicus)
Mammalia Bcl2l2 36
  • 94.3 (n)
  • 98.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia xR1 36
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl2l2 36
  • 67.03 (n)
  • 70.17 (a)
Species with no ortholog for BCL2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L2 Gene

Gene Tree for BCL2L2 (if available)
Gene Tree for BCL2L2 (if available)

Paralogs for BCL2L2 Gene

Paralogs for BCL2L2 Gene

Selected SIMAP similar genes for BCL2L2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BCL2L2: view

Variants for BCL2L2 Gene

Sequence variations from dbSNP and Humsavar for BCL2L2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_048418 -

Structural Variations from Database of Genomic Variants (DGV) for BCL2L2 Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Relevant External Links for BCL2L2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for BCL2L2 Gene

(6) Novoseek inferred disease relationships for BCL2L2 Gene

Disease -log(P) Hits PubMed IDs
cancer 26.8 3
adenoma 0.374 4
necrosis 0 3
adenocarcinoma 0 3
tumors 0 2

Relevant External Links for BCL2L2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BCL2L2: view

No data available for UniProtKB/Swiss-Prot for BCL2L2 Gene

Publications for BCL2L2 Gene

  1. Bcl-w, a novel member of the Bcl-2 family, promotes cell survival. (PMID: 8761287) Gibson L. … Cory S. (Oncogene 1996) 2 3 4 23
  2. Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. (PMID: 12651847) Denisov A.Y. … Gehring K. (J. Biol. Chem. 2003) 3 4 23
  3. Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. (PMID: 11483855) Bae J. … Hsueh A.J. (Apoptosis 2001) 3 23
  4. Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. (PMID: 10381646) Holmgreen S.P. … Cory S. (Cell Death Differ. 1999) 3 23
  5. Neuroprotective properties of Bcl-w in Alzheimer disease. (PMID: 15147516) Zhu X. … Smith M.A. (J. Neurochem. 2004) 3 23

Products for BCL2L2 Gene

Sources for BCL2L2 Gene

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