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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL2L2 Gene

protein-coding GIFtS: 65
GCID: GC14P023776

BCL2-like 2

Explore 39 diseases affiliated with
BCL2L2 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BCL2-Like 2¹ ²		Apoptosis Regulator Bcl-W² ³
BCLW² ³ ⁵		BCL2-L-2²
BCL-W¹ ²		Bcl-2-Like Protein 2²
PPP1R51¹ ²		Protein Phosphatase 1, Regulatory Subunit 51²
KIAA0271¹ ³		Bcl2-L-2³

External Ids:	HGNC: 995¹	Entrez Gene: 599²	Ensembl: ENSG00000129473⁷	OMIM: 601931⁵	UniProtKB: Q92843³

Export aliases for BCL2L2 gene to outside databases

Previous GC identifers: GC14P021148 GC14P017563 GC14P021766 GC14P022845 GC14P003892

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2L2:

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act

as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell

apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and

BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult

spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists

between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. (provided by

RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: B2CL2_HUMAN, Q92843

Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli

cells by suppressing death-promoting activity of BAX

Gene Wiki entry for BCL2L2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL2L2 gene promoter:
STAT1 E2F E2F-1 Sp1 E2F-2 c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BCL2L2 promoter sequence

Search SABiosciences Chromatin IP Primers for BCL2L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2-q12 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2-q12

BCL2L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P023776: view genomic region (about GC identifiers)

Start:	23,767,999 bp from pter	End:	23,780,968 bp from pter
Size:	12,970 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B2CL2_HUMAN, Q92843 (See protein sequence)

Recommended Name: Bcl-2-like protein 2

Size: 193 amino acids; 20746 Da

Subunit: Interacts with BOP (By similarity)

Subcellular location: Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the

mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane

Sequence caution: Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

4 PDB 3D structures from and Proteopedia for BCL2L2:

1MK3 (3D)

1O0L (3D)

1ZY3 (3D)

2Y6W (3D)

Secondary accessions: A8K0F4 Q2M3U0 Q5U0H4

Alternative splicing: 2 isoforms: Q92843-1 Q92843-2 (Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein. No experimental confirmation available. Contains a phosphoserine at position 177)

Explore the universe of human proteins at neXtProt for BCL2L2: NX_Q92843

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92843

BCL2L2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186768.1 NP_004041.1

ENSEMBL proteins:

ENSP00000451148 ENSP00000250405 ENSP00000451701 ENSP00000452265 ENSP00000451234

ENSP00000451197

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	ProSpec Recombinant Protein for BCL2L2
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--
GO:0031966	mitochondrial membrane	IEA	--

BCL2L2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCL2L2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR020731 Bcl2_BH4_motif_CS

IPR013280 Apop_reg_BclW

IPR003093 Bcl2_BH4

IPR002475 Bcl2-like

IPR026298 Blc2_fam

Graphical View of Domain Structure for InterPro Entry Q92843

ProtoNet protein and cluster: Q92843

2 Blocks protein families:

IPB000712 Apoptosis regulator Bcl-2 protein

IPB003093 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: B2CL2_HUMAN, Q92843

Domain: The BH4 motif seems to be involved in the anti-apoptotic function

Domain: The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some

pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival

activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing

its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: B2CL2_HUMAN, Q92843

Function: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli

cells by suppressing death-promoting activity of BAX

Genatlas biochemistry entry for BCL2L2:

BCL2-like 2,antiapoptotic,expressed in lymphoid and myeloid cells

miRNA Products:		miRTarBase miRNAs that target BCL2L2: hsa-mir-204 (MIRT005819), hsa-mir-122 (MIRT004364), hsa-mir-133b (MIRT001076), hsa-mir-630 (MIRT005579), hsa-mir-203 (MIRT005453)

		OriGene 3'-UTR Clone: BCL2L2 Browse MicroRNA Expression Plasmids
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		8/141 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2L2 (see all 141):
		hsa-miR-194* hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-106a hsa-miR-1224-3p hsa-miR-3921 hsa-miR-519a hsa-miR-1273d

		SwitchGear 3'UTR luciferase reporter plasmid: BCL2L2 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for BCL2L2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

BCL2L2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Bcl2l2^tm1Sco for BCL2L2
     7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bcl2l2):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	homeostasis/metabolism
nervous system	reproductive system

BCL2L2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Apoptosis

0.38

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

0.24

Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

0.24

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Direct p53 effectors

Direct p53 effectors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for BCL2L2

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

1 Cell Signaling Technology (CST) Pathway for BCL2L2

Apoptosis and Autophagy

1 GeneGo (Thomson Reuters) Pathway for BCL2L2

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

3 BioSystems Pathways for BCL2L2

	Apoptosis
	Apoptosis Modulation and Signaling
	Direct p53 effectors

BCL2L2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BCL2L2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/21 Interacting proteins for BCL2L2 (Q92843^{1, 2, 3} ENSP00000250405⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BBC3	Q9BXH1¹^,³, ENSP00000404503⁴	EBI-707714,EBI-519884 I2D: score=4 STRING: ENSP00000404503
BAX	Q07812¹^,³, ENSP00000293288⁴	EBI-707714,EBI-516580 I2D: score=2 STRING: ENSP00000293288
BCL2L11	O43521¹^,³	EBI-707714,EBI-1002160 I2D: score=5
TP53BP2	Q13625²^,³, ENSP00000341957⁴	MINT-7235907 MINT-7235618 I2D: score=1 STRING: ENSP00000341957
BID	P55957¹^,³, ENSP00000318822⁴	EBI-707714,EBI-519672 I2D: score=5 STRING: ENSP00000318822

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007283	spermatogenesis	TAS	8761287
GO:0042981	regulation of apoptotic process	--	--
GO:0043066	negative regulation of apoptotic process	IMP	17289999
GO:0060011	Sertoli cell proliferation	IEA	--

BCL2L2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BCL2L2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BCL2L2
1 Novoseek chemical compound relationship for BCL2L2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cisplatin	24.3	2	19240170 (1)

Search CenterWatch for drugs/clinical trials and news about BCL2L2 / B2CL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BCL2L2 gene (2 alternative transcripts):

NM_001199839.1 NM_004050.4

Unigene Cluster for BCL2L2:

BCL2-like 2

Hs.410026 [show with all ESTs]

Unigene Representative Sequence: NM_004050

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000553824 ENST00000250405(uc001wjg.4 uc021rqx.1 uc001wji.4)

ENST00000557236 ENST00000557579 ENST00000554635 ENST00000556599

miRNA Products:		OriGene 3'-UTR Clone: BCL2L2 Browse OriGene MicroRNA Expression Plasmids
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		8/141 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2L2 (see all 141):
		hsa-miR-194* hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-106a hsa-miR-1224-3p hsa-miR-3921 hsa-miR-519a hsa-miR-1273d

		SwitchGear 3'UTR luciferase reporter plasmid: BCL2L2 3' UTR sequence

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Additional cDNA sequence:

AK289519.1 BC021198.2 BC104789.1 BC113522.1 BT019549.1 D87461.1 U59747.1

10 DOTS entries:

DT.92015271 DT.95072625 DT.95196148 DT.100788706 DT.456241 DT.100788707 DT.95167766 DT.100045303

DT.100045304 DT.91901642

24/631 AceView cDNA sequences (see all 631):

BQ647068 CD678971 CR599417 BG323731 BX331373 CA430348 BU736669 CR613466

AI681508 AI827810 BM718927 AI335949 BE378332 AI493697 BM127838 AI755272

CA306227 BE044589 BU621314 BX354963 BM669990 BX247976 BQ925876 AA098908

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5a	·	5b
SP1:					-		-
SP2:							-
SP3:							-
SP4:
SP5:

ECgene alternative splicing isoforms for BCL2L2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL2L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAGGTTAC

About this image
See BCL2L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL2L2

SOURCE GeneReport for Unigene cluster: Hs.410026

UniProtKB/Swiss-Prot: B2CL2_HUMAN, Q92843

Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord,

testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not

detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial

origin. Not detected in most lymphoid cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2L2:

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L2 gene from 1/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
African clawed frog (Xenopus laevis)	Amphibia	xR1²	X.laevis R1 mRNA	77.57(n)		X82462.1

ENSEMBL Gene Tree for BCL2L2 (if available)
TreeFam Gene Tree for BCL2L2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BCL2L2 gene

BAK1² BCL2² BCL2L1² BAX²

5 SIMAP similar genes for BCL2L2 using alignment to 6 protein entries: B2CL2_HUMAN (see all proteins):

BCL2L2-PABPN1 BCL2L1 BCL2 bcl-2 BAX

BCL2L2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139104616^1,2		--	23774021(+)	`GCAACA/GTAATG`	3	--	us2k¹		0	--	--	--	--
rs184256203^1,2		--	23774110(+)	`AAGTGA/GGAAGA`	3	--	us2k¹		0	--	--	--	--
rs75497041^1,2	C,F,	--	23774161(+)	`NNNNAC/TCACTG`	3	--	us2k¹		1		NA	120
rs188437107^1,2		--	23774204(+)	`GTATCA/GCAAAC`	3	--	us2k¹		0	--	--	--	--
rs192508957^1,2		--	23774227(+)	`CAGGAA/GTGCAA`	3	--	us2k¹		0	--	--	--	--
rs116490250^1,2	F,	--	23774243(+)	`GACTTG/CGACTA`	3	--	us2k¹		1		WA	118
rs144803569^1,2		--	23774309(+)	`TAAGAA/GCAAAA`	3	--	us2k¹		0	--	--	--	--
rs113250906^1,2	C,	--	23774436(+)	`AACCAC/TATTGA`	3	--	us2k¹		0	--	--	--	--
rs116087065^1,2		--	23774580(+)	`TTCATA/GGAATG`	3	--	us2k¹		1		WA	118
rs141066031^1,2	C,	--	23774631(+)	`ACATG-/TAAAAA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BCL2L2 (23767999 - 23780968 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BCL2L2: --
Human Gene Mutation Database (HGMD): BCL2L2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BCL2L2 for disorders           About GeneDecksing

OMIM gene information: 601931    OMIM disorders: --

20/39 diseases for BCL2L2 (see all 39):    About MalaCards

spinal cord injury non-hodgkin lymphoma severe acute respiratory syndrome parathyroid adenoma

hodgkin's lymphoma male infertility acute lymphoblastic leukemia chronic lymphocytic leukemia

chronic myeloid leukemia lymphoblastic leukemia lymphocytic leukemia neuronitis

myeloid leukemia squamous cell carcinoma multiple myeloma leukemia

alzheimer's disease adenoma infertility myeloma

6 Novoseek disease relationships for BCL2L2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	26.8	3	18767026 (1), 16996562 (1), 18289121 (1)
adenoma	0.374	4	10944610 (2), 10638987 (2)
necrosis	0	3	20062536 (2), 12696008 (1)
adenocarcinoma	0	3	10638987 (3)
tumors	0	2	12696008 (1), 16996562 (1)
alzheimers disease	0	1	15147516 (1)

Human Genome Epidemiology (HuGE) Navigator: BCL2L2 (11 documents)

Export disorders for BCL2L2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BCL2L2 gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with BCL2L2)

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Bcl-w, a novel member of the Bcl-2 family, promotes cell survival. (PubMed id 8761287)^{1, 2, 3, 9} Gibson L.... Cory S. (1996)
Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. (PubMed id 12651847)^{1, 2, 9} Denisov A.Y.... Gehring K. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. (PubMed id 12660157)^{1, 2} Hinds M.G....Day C.L. (2003)
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. (PubMed id 12952938)^{1, 2} Wilson-Annan J.... Huang D.C.S. (2003)
Tissue expression and subcellular localization of the pro-survival molecule Bcl-w. (PubMed id 11423909)^{1, 2} O'Reilly L.A.... Strasser A. (2001)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2} Nagase T....Nomura N. (1996)
Neuroprotective properties of Bcl-w in Alzheimer disease. (PubMed id 15147516)^{1, 9} Zhu X....Smith M.A. (2004)
Akt regulates drug-induced cell death through Bcl-w downregulation. (PubMed id 19114998)^{1, 9} Garofalo M....Condorelli G. (2008)
Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis. (PubMed id 20062536)^{1, 9} Crawford A.C....Clarke R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 599	HGNC: 995	AceView: BCL2L2andPABPN1	Ensembl:ENSG00000129473	euGenes: HUgn599
ECgene: BCL2L2	H-InvDB: BCL2L2

(According to HUGE)
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HUGE: KIAA0271

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BCL2L2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BCL2L2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BCL2L2 gene
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Patent Information for BCL2L2 gene:
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GeneCards and IP:
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