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Aliases for BCL2L2 Gene

Aliases for BCL2L2 Gene

  • BCL2 Like 2 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 51 2 3
  • Bcl2-L-2 3 4
  • BCLW 3 4
  • Apoptosis Regulator Bcl-W 4
  • Apoptosis Regulator BCL-W 3
  • Bcl-2-Like Protein 2 3
  • KIAA0271 4
  • PPP1R51 3
  • BCL-W 3

External Ids for BCL2L2 Gene

Previous GeneCards Identifiers for BCL2L2 Gene

  • GC14P021148
  • GC14P017563
  • GC14P021766
  • GC14P022845
  • GC14P023776
  • GC14P003892
  • GC14P023791
  • GC14P023464
  • GC14P023564
  • GC14P023677
  • GC14P023800
  • GC14P023889

Summaries for BCL2L2 Gene

Entrez Gene Summary for BCL2L2 Gene

  • This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for BCL2L2 Gene

BCL2L2 (BCL2 Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include Small Intestinal Adenocarcinoma. Among its related pathways are Apoptosis and Autophagy and Regulation of Apoptosis by Parathyroid Hormone-related Protein. GO annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.

UniProtKB/Swiss-Prot for BCL2L2 Gene

  • Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Gene Wiki entry for BCL2L2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L2 Gene

Genomics for BCL2L2 Gene

Regulatory Elements for BCL2L2 Gene

Enhancers for BCL2L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022504 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10 -760.6 -760603 66.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 MMP14 ABHD4 OXA1L EFS BCL2L2-PABPN1 DAD1 LOC105370399 TRAC C14orf119 OR6J1
GH14G022976 1.9 FANTOM5 ENCODE dbSUPER 10 -318.9 -318885 7.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 PRMT5 HAUS4 LOC102724814 MMP14 PSMB5 C14orf119 CDH24 C14orf93 PSMB11 PABPN1
GH14G022456 1.7 Ensembl ENCODE dbSUPER 10 -839.5 -839467 6.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 METTL3 PABPN1 HOMEZ BCL2L2 TRDJ3 TRDC
GH14G022587 1.7 FANTOM5 ENCODE dbSUPER 10 -709.7 -709717 3.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 MMP14 PABPN1 OXA1L DAD1 ABHD4 OR6J1 BCL2L2 LRP10 REM2 LINC02332
GH14G022927 1.4 ENCODE dbSUPER 10 -369.2 -369183 3.2 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC HAUS4 LOC102724814 BCL2L2-PABPN1 PABPN1 PPP1R3E BCL2L2 ENSG00000258457 PRMT5 LOC101926933
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCL2L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCL2L2 Gene

Chromosome:
14
Start:
23,298,790 bp from pter
End:
23,311,759 bp from pter
Size:
12,970 bases
Orientation:
Plus strand

Genomic View for BCL2L2 Gene

Genes around BCL2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L2 Gene

Proteins for BCL2L2 Gene

  • Protein details for BCL2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92843-B2CL2_HUMAN
    Recommended name:
    Bcl-2-like protein 2
    Protein Accession:
    Q92843
    Secondary Accessions:
    • A8K0F4
    • Q2M3U0
    • Q5U0H4

    Protein attributes for BCL2L2 Gene

    Size:
    193 amino acids
    Molecular mass:
    20746 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    • Interacts with HIF3A (via C-terminus domain). Interacts with BOP.
    SequenceCaution:
    • Sequence=BAA19666.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L2 Gene

    Alternative splice isoforms for BCL2L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2L2 Gene

Post-translational modifications for BCL2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL2L2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCL2L2 (BCL2L2)
  • Cloud-Clone Corp. Antibodies for BCL2L2
  • Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L2

Protein Products

No data available for DME Specific Peptides for BCL2L2 Gene

Domains & Families for BCL2L2 Gene

Suggested Antigen Peptide Sequences for BCL2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92843

UniProtKB/Swiss-Prot:

B2CL2_HUMAN :
  • The BH4 motif seems to be involved in the anti-apoptotic function.
  • Belongs to the Bcl-2 family.
Domain:
  • The BH4 motif seems to be involved in the anti-apoptotic function.
  • The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L2: view

Function for BCL2L2 Gene

Molecular function for BCL2L2 Gene

GENATLAS Biochemistry:
BCL2-like 2,antiapoptotic,expressed in lymphoid and myeloid cells
UniProtKB/Swiss-Prot Function:
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Gene Ontology (GO) - Molecular Function for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15694340
GO:0046982 protein heterodimerization activity IEA,IMP 16645638
GO:0051400 BH domain binding IEA --
GO:0097718 disordered domain specific binding IPI 16645638
genes like me logo Genes that share ontologies with BCL2L2: view
genes like me logo Genes that share phenotypes with BCL2L2: view

Animal Models for BCL2L2 Gene

MGI Knock Outs for BCL2L2:

Animal Model Products

CRISPR Products

miRNA for BCL2L2 Gene

miRTarBase miRNAs that target BCL2L2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L2 Gene

Localization for BCL2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L2 Gene

Mitochondrion membrane; Peripheral membrane protein. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L2 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 4
plasma membrane 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BCL2L2: view

Pathways & Interactions for BCL2L2 Gene

genes like me logo Genes that share pathways with BCL2L2: view

Pathways by source for BCL2L2 Gene

SIGNOR curated interactions for BCL2L2 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BCL2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007283 spermatogenesis TAS 8761287
GO:0042981 regulation of apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process TAS,IMP 17289999
GO:0060011 Sertoli cell proliferation IEA --
genes like me logo Genes that share ontologies with BCL2L2: view

Drugs & Compounds for BCL2L2 Gene

(10) Drugs for BCL2L2 Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ABT-263 Investigational Pharma Target 0
ABT-263 (Navitoclax) Pharma Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w 0
ABT-737 Pharma Bcl-2 inhibitor 0
AT-101 Pharma BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors 0
Bax inhibitor peptide P5 Pharma Bax inhibitor 0

(7) ApexBio Compounds for BCL2L2 Gene

Compound Action Cas Number
ABT-263 (Navitoclax) Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w 923564-51-6
ABT-737 Bcl-2 inhibitor 852808-04-9
AT-101 BH3-mimetic,gossypol enantiomer 90141-22-3
Bax inhibitor peptide P5 Bax inhibitor 579492-83-4
Bax inhibitor peptide V5 Bax inhibitor 579492-81-2
Gossypol PAF inhibitor;anti-fertility and anti-cancer 303-45-7
Sabutoclax pan-Bcl-2 inhibitor 1228108-65-3
genes like me logo Genes that share compounds with BCL2L2: view

Drug Products

Transcripts for BCL2L2 Gene

Unigene Clusters for BCL2L2 Gene

BCL2-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for BCL2L2 Gene

GeneLoc Exon Structure for
BCL2L2
ECgene alternative splicing isoforms for
BCL2L2

Expression for BCL2L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L2 Gene

Protein differential expression in normal tissues from HIPED for BCL2L2 Gene

This gene is overexpressed in Bone (13.8) and Frontal cortex (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2L2 Gene



Protein tissue co-expression partners for BCL2L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL2L2 Gene:

BCL2L2

SOURCE GeneReport for Unigene cluster for BCL2L2 Gene:

Hs.410026

mRNA Expression by UniProt/SwissProt for BCL2L2 Gene:

Q92843-B2CL2_HUMAN
Tissue specificity: Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.

Evidence on tissue expression from TISSUES for BCL2L2 Gene

  • Nervous system(4.6)
  • Lung(4.4)
  • Liver(4.3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with BCL2L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L2 Gene

Orthologs for BCL2L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2L2 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia BCL2L2 34 35
  • 95.85 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL2L2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL2L2 34 35
  • 94.82 (n)
rat
(Rattus norvegicus)
Mammalia Bcl2l2 34
  • 94.3 (n)
mouse
(Mus musculus)
Mammalia Bcl2l2 34 16 35
  • 93.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BCL2L2 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl2l2 34
  • 67.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia xR1 34
Species where no ortholog for BCL2L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L2 Gene

ENSEMBL:
Gene Tree for BCL2L2 (if available)
TreeFam:
Gene Tree for BCL2L2 (if available)

Paralogs for BCL2L2 Gene

Paralogs for BCL2L2 Gene

(5) SIMAP similar genes for BCL2L2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BCL2L2: view

Variants for BCL2L2 Gene

Sequence variations from dbSNP and Humsavar for BCL2L2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000038650 -- 23,309,658(+) GAAAG(C/T)GATTG intron-variant, utr-variant-3-prime
rs1000946613 -- 23,310,177(+) AGCCA(C/T)ACTGT intron-variant, utr-variant-3-prime
rs1001383421 -- 23,309,267(+) TGGAA(C/T)TTGCT intron-variant, utr-variant-3-prime
rs1001866831 -- 23,304,779(+) TCAAG(C/T)TGGCC upstream-variant-2KB
rs1002085630 -- 23,304,872(+) ACCTC(G/T)AGTCC upstream-variant-2KB

Variation tolerance for BCL2L2 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L2 Gene

Human Gene Mutation Database (HGMD)
BCL2L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCL2L2 Gene

Disorders for BCL2L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCL2L2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
small intestinal adenocarcinoma
  • adenocarcinoma of small bowel
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BCL2L2

Genetic Association Database (GAD)
BCL2L2
Human Genome Epidemiology (HuGE) Navigator
BCL2L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L2
genes like me logo Genes that share disorders with BCL2L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L2 Gene

Publications for BCL2L2 Gene

  1. Bcl-w, a novel member of the Bcl-2 family, promotes cell survival. (PMID: 8761287) Gibson L. … Cory S. (Oncogene 1996) 2 3 4 22 64
  2. Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. (PMID: 12651847) Denisov A.Y. … Gehring K. (J. Biol. Chem. 2003) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 64
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly J.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for BCL2L2 Gene

Sources for BCL2L2 Gene

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