Aliases for BCL2L2 Gene
External Ids for BCL2L2 Gene
Previous GeneCards Identifiers for BCL2L2 Gene
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for BCL2L2 Gene
BCL2L2 (BCL2 Like 2) is a Protein Coding gene. Diseases associated with BCL2L2 include Small Intestinal Adenocarcinoma. Among its related pathways are Apoptosis and Autophagy and Regulation of Apoptosis by Parathyroid Hormone-related Protein. GO annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.
UniProtKB/Swiss-Prot for BCL2L2 Gene
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.