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Aliases for BCL2L15 Gene

Aliases for BCL2L15 Gene

  • BCL2 Like 15 2 3 5
  • Bcl2-L-15 3 4
  • C1orf178 3 4
  • Chromosome 1 Open Reading Frame 178 2
  • Pro-Apoptotic Bcl-2 Protein 3
  • Bcl-2-Like Protein 15 3
  • Bfk 3

External Ids for BCL2L15 Gene

Previous HGNC Symbols for BCL2L15 Gene

  • C1orf178

Previous GeneCards Identifiers for BCL2L15 Gene

  • GC01M114220
  • GC01M114419
  • GC01M112277

Summaries for BCL2L15 Gene

GeneCards Summary for BCL2L15 Gene

BCL2L15 (BCL2 Like 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L15 Gene

Genomics for BCL2L15 Gene

Regulatory Elements for BCL2L15 Gene

Enhancers for BCL2L15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F113857 1.3 Ensembl ENCODE 11.6 +27.7 27693 4.7 TBL1XR1 CHAMP1 ZNF207 RCOR1 CREM JUNB TBX21 SMARCB1 SP1 MAFF HIPK1 AP4B1 DCLRE1B BCL2L15 HIPK1-AS1 PTPN22 OLFML3 PHTF1 GC01M113841
GH01F113911 1 Ensembl ENCODE 10.7 -25.3 -25250 2.0 PKNOX1 JUN FEZF1 YBX1 FOSL1 PRDM10 TRIM24 HLF GATAD2B POLR2H RSBN1 BCL2L15 TRIM33 ENSG00000231128 OLFML3 GC01P113912 AP4B1
GH01F113914 0.8 ENCODE 10.7 -26.9 -26907 0.2 PKNOX1 ATF1 ARNT ELK1 GATA2 NCOA1 CREB3 MBD2 MEF2D SMARCA4 BCL2L15 ENSG00000231128 RSBN1 TRIM33 OLFML3 GC01P113912 HIPK1
GH01F113942 0.7 Ensembl 4.5 -55.8 -55831 0.8 ZNF146 HLF NR2F1 CEBPB ZNF140 CEBPG EP300 CEBPA ZNF580 NR2F6 LRIG2 TRIM33 SIKE1 LOC100421402 AP4B1-AS1 BCL2L15 HIPK1-AS1 OLFML3
GH01F113886 1 Ensembl ENCODE 0.8 0.0 -16 2.3 ZNF121 NBN YBX1 PRDM10 TCF7L2 AP4B1-AS1 AP4B1 BCL2L15 DCLRE1B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BCL2L15 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCL2L15 Gene

Chromosome:
1
Start:
113,876,814 bp from pter
End:
113,887,547 bp from pter
Size:
10,734 bases
Orientation:
Minus strand

Genomic View for BCL2L15 Gene

Genes around BCL2L15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L15 Gene

Proteins for BCL2L15 Gene

  • Protein details for BCL2L15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TBC7-B2L15_HUMAN
    Recommended name:
    Bcl-2-like protein 15
    Protein Accession:
    Q5TBC7
    Secondary Accessions:
    • A0PJY6
    • A8K074
    • I6LA82

    Protein attributes for BCL2L15 Gene

    Size:
    163 amino acids
    Molecular mass:
    17725 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2L15 Gene

Post-translational modifications for BCL2L15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL2L15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL2L15 Gene

Domains & Families for BCL2L15 Gene

Gene Families for BCL2L15 Gene

Protein Domains for BCL2L15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL2L15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCL2L15: view

No data available for UniProtKB/Swiss-Prot for BCL2L15 Gene

Function for BCL2L15 Gene

Gene Ontology (GO) - Molecular Function for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BCL2L15: view

Phenotypes for BCL2L15 Gene

genes like me logo Genes that share phenotypes with BCL2L15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L15 Gene

Localization for BCL2L15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2L15 Gene COMPARTMENTS Subcellular localization image for BCL2L15 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with BCL2L15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL2L15 Gene

Pathways & Interactions for BCL2L15 Gene

SuperPathways for BCL2L15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BCL2L15: view

No data available for Pathways by source and SIGNOR curated interactions for BCL2L15 Gene

Drugs & Compounds for BCL2L15 Gene

(2) Drugs for BCL2L15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for BCL2L15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BCL2L15: view

Transcripts for BCL2L15 Gene

Unigene Clusters for BCL2L15 Gene

BCL2-like 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L15 Gene

No ASD Table

Relevant External Links for BCL2L15 Gene

GeneLoc Exon Structure for
BCL2L15
ECgene alternative splicing isoforms for
BCL2L15

Expression for BCL2L15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCL2L15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L15 Gene

This gene is overexpressed in Colon - Transverse (x16.3), Small Intestine - Terminal Ileum (x10.1), Pancreas (x6.3), and Stomach (x4.9).

Protein differential expression in normal tissues from HIPED for BCL2L15 Gene

This gene is overexpressed in Nasal epithelium (44.1) and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL2L15 Gene



NURSA nuclear receptor signaling pathways regulating expression of BCL2L15 Gene:

BCL2L15

SOURCE GeneReport for Unigene cluster for BCL2L15 Gene:

Hs.123106
genes like me logo Genes that share expression patterns with BCL2L15: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BCL2L15 Gene

Orthologs for BCL2L15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2L15 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia BCL2L15 34 35
  • 86.3 (n)
cow
(Bos Taurus)
Mammalia BCL2L15 34 35
  • 83.12 (n)
rat
(Rattus norvegicus)
Mammalia Bcl2l15 34
  • 78.4 (n)
mouse
(Mus musculus)
Mammalia Bcl2l15 34 16 35
  • 77.91 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL2L15 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCL2L15 34 35
  • 55.94 (n)
Species where no ortholog for BCL2L15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L15 Gene

ENSEMBL:
Gene Tree for BCL2L15 (if available)
TreeFam:
Gene Tree for BCL2L15 (if available)

Paralogs for BCL2L15 Gene

(1) SIMAP similar genes for BCL2L15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BCL2L15: view

No data available for Paralogs for BCL2L15 Gene

Variants for BCL2L15 Gene

Sequence variations from dbSNP and Humsavar for BCL2L15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1018592 -- 113,887,996(+) TCAGT(G/T)CACTT intron-variant, upstream-variant-2KB
rs11102690 -- 113,877,338(+) TTTTT(A/T)AAAAA intron-variant, utr-variant-3-prime
rs11102691 -- 113,878,691(+) CTCAT(C/T)ATCTT intron-variant, utr-variant-3-prime
rs11102692 -- 113,880,583(+) atcgc(A/G)ccact intron-variant, utr-variant-3-prime
rs11102693 -- 113,880,604(+) CTGGG(C/T)GACAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BCL2L15 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV loss 19812545
esv3587240 CNV loss 21293372
esv3587251 CNV loss 21293372

Variation tolerance for BCL2L15 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL2L15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L15 Gene

Disorders for BCL2L15 Gene

Relevant External Links for BCL2L15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L15

No disorders were found for BCL2L15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L15 Gene

Publications for BCL2L15 Gene

  1. Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. (PMID: 15961081) Dempsey C.E. … Renshaw S.A. (FEBS Lett. 2005) 2 3 4 22 64
  2. Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization. (PMID: 17412810) Pujianto D.A. … Poutanen M. (Endocrinology 2007) 2 3 64
  3. Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. (PMID: 16690252) Luo H.Y. … Li T.J. (Int J Oral Maxillofac Surg 2006) 2 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for BCL2L15 Gene

Sources for BCL2L15 Gene

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