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Aliases for BCL2L15 Gene

Aliases for BCL2L15 Gene

  • BCL2 Like 15 2 3 5
  • Bcl2-L-15 3 4
  • C1orf178 3 4
  • Chromosome 1 Open Reading Frame 178 2
  • Pro-Apoptotic Bcl-2 Protein 3
  • Bcl-2-Like Protein 15 3
  • Bfk 3

External Ids for BCL2L15 Gene

Previous HGNC Symbols for BCL2L15 Gene

  • C1orf178

Previous GeneCards Identifiers for BCL2L15 Gene

  • GC01M114220
  • GC01M114419
  • GC01M112277

Summaries for BCL2L15 Gene

GeneCards Summary for BCL2L15 Gene

BCL2L15 (BCL2 Like 15) is a Protein Coding gene. Among its related pathways are Regulation of Apoptosis by Parathyroid Hormone-related Protein.

Additional gene information for BCL2L15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L15 Gene

Genomics for BCL2L15 Gene

Regulatory Elements for BCL2L15 Gene

Enhancers for BCL2L15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H113857 1.1 Ensembl ENCODE 11.6 +27.7 27693 4 HDAC1 TBL1XR1 NFRKB SIN3A BATF ZNF207 ATF7 RCOR1 RUNX3 CREM HIPK1 AP4B1 DCLRE1B BCL2L15 HIPK1-AS1 PTPN22 OLFML3 PHTF1 GC01M113841
GH01H113914 1 ENCODE 10.8 -26.9 -26907 0 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 ZC3H11A NCOA1 BCL2L15 RSBN1 ENSG00000231128 LOC100421402 OLFML3 GC01P113912 HIPK1
GH01H113911 0.8 Ensembl ENCODE 10.8 -25.3 -25250 1 NFIC IKZF1 ZBTB33 PRDM10 BCL2L15 ENSG00000231128 RSBN1 OLFML3 GC01P113912 AP4B1
GH01H113941 0.7 dbSUPER 4.5 -55.4 -55441 2 ZNF146 HLF ZNF140 CEBPB CEBPG EP300 ZNF316 POLR2A CEBPA ZNF580 LRIG2 TRIM33 SIKE1 LOC100421402 AP4B1-AS1 BCL2L15 HIPK1-AS1 OLFML3
GH01H113965 0.2 dbSUPER 4.7 -78.7 -78659 0 BCL2L15 OLFML3 HIPK1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCL2L15 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCL2L15 Gene

Chromosome:
1
Start:
113,876,814 bp from pter
End:
113,887,547 bp from pter
Size:
10,734 bases
Orientation:
Minus strand

Genomic View for BCL2L15 Gene

Genes around BCL2L15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L15 Gene

Proteins for BCL2L15 Gene

  • Protein details for BCL2L15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TBC7-B2L15_HUMAN
    Recommended name:
    Bcl-2-like protein 15
    Protein Accession:
    Q5TBC7
    Secondary Accessions:
    • A0PJY6
    • A8K074
    • I6LA82

    Protein attributes for BCL2L15 Gene

    Size:
    163 amino acids
    Molecular mass:
    17725 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2L15 Gene

Post-translational modifications for BCL2L15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL2L15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL2L15 Gene

Domains & Families for BCL2L15 Gene

Gene Families for BCL2L15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BCL2L15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL2L15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCL2L15: view

No data available for UniProtKB/Swiss-Prot for BCL2L15 Gene

Function for BCL2L15 Gene

Phenotypes From GWAS Catalog for BCL2L15 Gene

Gene Ontology (GO) - Molecular Function for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BCL2L15: view

Phenotypes for BCL2L15 Gene

genes like me logo Genes that share phenotypes with BCL2L15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BCL2L15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L15 Gene

Localization for BCL2L15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L15 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with BCL2L15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for BCL2L15 Gene

Pathways & Interactions for BCL2L15 Gene

genes like me logo Genes that share pathways with BCL2L15: view

Pathways by source for BCL2L15 Gene

Gene Ontology (GO) - Biological Process for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with BCL2L15: view

No data available for SIGNOR curated interactions for BCL2L15 Gene

Drugs & Compounds for BCL2L15 Gene

(2) Drugs for BCL2L15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for BCL2L15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BCL2L15: view

Transcripts for BCL2L15 Gene

Unigene Clusters for BCL2L15 Gene

BCL2-like 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BCL2L15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L15 Gene

No ASD Table

Relevant External Links for BCL2L15 Gene

GeneLoc Exon Structure for
BCL2L15
ECgene alternative splicing isoforms for
BCL2L15

Expression for BCL2L15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L15 Gene

This gene is overexpressed in Colon - Transverse (x16.3), Small Intestine - Terminal Ileum (x10.1), Pancreas (x6.3), and Stomach (x4.9).

Protein differential expression in normal tissues from HIPED for BCL2L15 Gene

This gene is overexpressed in Nasal epithelium (44.1) and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL2L15 Gene



NURSA nuclear receptor signaling pathways regulating expression of BCL2L15 Gene:

BCL2L15

SOURCE GeneReport for Unigene cluster for BCL2L15 Gene:

Hs.123106
genes like me logo Genes that share expression patterns with BCL2L15: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L15 Gene

Orthologs for BCL2L15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2L15 33 34
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia BCL2L15 33 34
  • 86.3 (n)
cow
(Bos Taurus)
Mammalia BCL2L15 33 34
  • 83.12 (n)
rat
(Rattus norvegicus)
Mammalia Bcl2l15 33
  • 78.4 (n)
mouse
(Mus musculus)
Mammalia Bcl2l15 33 16 34
  • 77.91 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL2L15 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCL2L15 33 34
  • 55.94 (n)
Species where no ortholog for BCL2L15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L15 Gene

ENSEMBL:
Gene Tree for BCL2L15 (if available)
TreeFam:
Gene Tree for BCL2L15 (if available)

Paralogs for BCL2L15 Gene

(1) SIMAP similar genes for BCL2L15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BCL2L15: view

No data available for Paralogs for BCL2L15 Gene

Variants for BCL2L15 Gene

Sequence variations from dbSNP and Humsavar for BCL2L15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000019424 -- 113,887,188(+) TCACT(G/T)CGCCC intron-variant
rs1000148245 -- 113,888,142(+) AAAAA(A/G)GAGGC intron-variant, upstream-variant-2KB
rs1001745390 -- 113,878,879(+) AGTTT(C/T)GCTTT intron-variant, utr-variant-3-prime
rs1001821199 -- 113,882,720(+) GATCA(C/T)ATGAG intron-variant
rs1001874911 -- 113,883,092(+) CCAAG(C/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L15 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV loss 19812545
esv3587240 CNV loss 21293372
esv3587251 CNV loss 21293372

Variation tolerance for BCL2L15 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL2L15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L15 Gene

Disorders for BCL2L15 Gene

Relevant External Links for BCL2L15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L15

No disorders were found for BCL2L15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L15 Gene

Publications for BCL2L15 Gene

  1. Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. (PMID: 15961081) Dempsey CE … Renshaw SA (FEBS letters 2005) 2 3 4 22 60
  2. Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization. (PMID: 17412810) Pujianto DA … Poutanen M (Endocrinology 2007) 2 3 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. (PMID: 16690252) Luo HY … Li TJ (International journal of oral and maxillofacial surgery 2006) 2 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for BCL2L15 Gene

Sources for BCL2L15 Gene

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