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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL2L15 Gene

protein-coding GIFtS: 41
GCID: GC01M114419

BCL2-like 15

(Previous name: chromosome 1 open reading frame 178 )
(Previous symbol: C1orf178)

Explore 17 diseases affiliated with
BCL2L15 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BCL2-Like 15¹ ²		Bcl-2-Like Protein 15²
C1orf178¹ ² ³		Bcl2-L-15³
Bfk¹ ²		Pro-Apoptotic Bcl-2 Protein²
FLJ22588¹		Bcl2-L-15³
Chromosome 1 Open Reading Frame 178¹

External Ids:	HGNC: 33624¹	Entrez Gene: 440603²	Ensembl: ENSG00000188761⁷	UniProtKB: Q5TBC7³

Export aliases for BCL2L15 gene to outside databases

Previous GC identifers: GC01M114220 GC01M112277

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL2L15 gene promoter:
AML1a GATA-3 HTF Lmo2 RORalpha2 MEF-2A PPAR-gamma1 FOXJ2 (long isoform) PPAR-gamma2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BCL2L15 promoter sequence

Search SABiosciences Chromatin IP Primers for BCL2L15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2L15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2

BCL2L15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L15 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M114419: view genomic region (about GC identifiers)

Start:	114,419,436 bp from pter	End:	114,430,169 bp from pter
Size:	10,734 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B2L15_HUMAN, Q5TBC7 (See protein sequence)

Recommended Name: Bcl-2-like protein 15

Size: 163 amino acids; 17725 Da

Secondary accessions: A0PJY6 A8K074

Explore the universe of human proteins at neXtProt for BCL2L15: NX_Q5TBC7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5TBC7

BCL2L15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001010922.1

ENSEMBL proteins:

ENSP00000376992 ENSP00000376995 ENSP00000417458

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	IEA	--

BCL2L15 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5TBC7

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BCL2L15

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--

BCL2L15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BCL2L15 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BCL2L15
3 Novoseek chemical compound relationships for BCL2L15 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipid	0.165	1	18291090 (1)
oxygen	0	1	15601573 (1)
calcium	0	1	17371290 (1)

Search CenterWatch for drugs/clinical trials and news about BCL2L15 / B2L15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for BCL2L15 gene (4 alternative transcripts):

NM_001029944.1 NM_001029945.1 NM_001029946.1 NM_001010922.2

Unigene Cluster for BCL2L15:

BCL2-like 15

Hs.123106 [show with all ESTs]

Unigene Representative Sequence: NM_001010922

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369580(uc001edw.3 uc001edx.3 uc001edy.3) ENST00000393316(uc001edz.1)

ENST00000488450 ENST00000393320 ENST00000471267 ENST00000486485

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Additional cDNA sequence:

AK026241.1 AK289439.1 AY265861.1 AY265862.1 AY265863.1 AY265864.1 BC127719.1 BC127720.1

BC132904.1 BC132906.1

6 DOTS entries:

DT.75100992 DT.70101895 DT.99961115 DT.305715 DT.97824568 DT.75128994

24/25 AceView cDNA sequences (see all 25):

AI821052 CB142909 BX091865 BM755890 BX091267 AA594246 CA312911 AW138724

BM829833 AI802637 AW004997 AI821801 AW204165 AK026241 CR749373 AA877677

AW137209 AI821221 BF445012 AI632962 BU607853 BX644415 AA483638 BX483608

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL2L15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACATCGATA

About this image
See BCL2L15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL2L15

SOURCE GeneReport for Unigene cluster: Hs.123106

SABiosciences Custom PCR Arrays for BCL2L15

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L15 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bcl2l15^{1 , 5}	BCLl2-like 15^{1, 5}	77.91(n)¹ 71.17(a)¹		3 (45.52 cM)⁵ 229672¹ NM_001142959.1¹ NP_001136431.1¹ 103832601⁵
chicken (Gallus gallus)	Aves	BCL2L15¹	BCL2-like 15	54.34(n) 41.78(a)		772088 XM_001233930.2 XP_001233931.1

ENSEMBL Gene Tree for BCL2L15 (if available)
TreeFam Gene Tree for BCL2L15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188546708^1,2		--	114419083(+)	`TTGCTA/GTTGTC`	2	--	int¹ ds500¹		0	--	--	--	--
rs2358816^1,2	C,F,A,H,	--	114419368(+)	`TTTTTA/TAAATA`	2	--	int¹ ds500¹		6		NS EA NA	626
rs199793648^1,2		--	114419368(+)	`TTTTT-/AAAATA`	2	--	int¹ ds500¹		0	--	--	--	--
rs112275192^1,2		--	114419439(+)	`CATCTG/AAGTCA`	2	--	int¹ ut3¹		1		CSA	2
rs184718856^1,2		--	114419482(+)	`AATATC/TGATGT`	2	--	ut3¹ int¹		0	--	--	--	--
rs11584821^1,2	C,F,H,	--	114419489(+)	`ATGTAC/TATGCC`	2	--	int¹ ut3¹		15		NS EA NA WA	1004
rs11580882^1,2	C,H	--	114419548(+)	`ATTCAG/TCAATC`	2	--	int¹ ut3¹		4		NS EA	418
rs1217384^1,2	C,F,O,A,H,	--	114419760(-)	`ATATTG/CCTTTT`	2	--	int¹ ut3¹		33		MN NS EA NA WA CSA	2925
rs189531493^1,2		--	114419783(+)	`ACAGTA/GGGAGG`	2	--	int¹ ut3¹		0	--	--	--	--
rs115216230^1,2	C,F,	--	114419812(+)	`GGCTCG/AGTTAT`	2	--	int¹ ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for BCL2L15 (114419436 - 114430169 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for BCL2L15
3 CNVs: 2322 3306 64644

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BCL2L15 for disorders About GeneDecksing

17 diseases for BCL2L15: About MalaCards

contagious pustular dermatitis drug-induced hepatitis rhinotracheitis dermatitis

ischemia cervical carcinoma hepatocellular carcinoma seizures

cervicitis colorectal cancer lung cancer breast cancer

hepatitis carcinoma retinitis melanoma

neuronitis

3 Novoseek disease relationships for BCL2L15 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	10.4	3	9422523 (1), 17392282 (1), 17921043 (1)
necrosis	8.96	2	17520191 (1), 17029566 (1)
ischemia	0	1	19696224 (1)

Export disorders for BCL2L15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BCL2L15 gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with BCL2L15)

Utopia: connect your pdf to the dynamic
world of online information

Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. (PubMed id 15961081)^{1, 3, 9} Dempsey C.E....Renshaw S.A. (2005)
Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization. (PubMed id 17412810)^{1, 3} Pujianto D.A....Poutanen M. (2007)
Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. (PubMed id 16690252)^{1, 3} Luo H.Y....Li T.J. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region. (PubMed id 12700646)^{1, 3} Coultas L....Strasser A. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels. (PubMed id 17881896)⁹ Ewings K.E....Cook S.J. (2007)
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. (PubMed id 19726685)⁹ Lee E.F....Fairlie W.D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 440603	HGNC: 33624	AceView: LOC440603	Ensembl:ENSG00000188761	euGenes: HUgn440603
ECgene: BCL2L15	H-InvDB: BCL2L15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BCL2L15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BCL2L15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BCL2L15 gene:
Search GeneIP for patents involving BCL2L15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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BCL2L15 Gene

BCL2-like 15

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BCL2L15 Gene

BCL2-like 15

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