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Aliases for BCL2L15 Gene

Aliases for BCL2L15 Gene

  • BCL2-Like 15 2 3
  • Bcl2-L-15 3 4
  • C1orf178 3 4
  • Chromosome 1 Open Reading Frame 178 2
  • Pro-Apoptotic Bcl-2 Protein 3
  • Bfk 3

External Ids for BCL2L15 Gene

Previous HGNC Symbols for BCL2L15 Gene

  • C1orf178

Previous GeneCards Identifiers for BCL2L15 Gene

  • GC01M114220
  • GC01M114419
  • GC01M112277

Summaries for BCL2L15 Gene

GeneCards Summary for BCL2L15 Gene

BCL2L15 (BCL2-Like 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L15 Gene

Genomics for BCL2L15 Gene

Regulatory Elements for BCL2L15 Gene

Genomic Location for BCL2L15 Gene

Chromosome:
1
Start:
113,876,814 bp from pter
End:
113,887,547 bp from pter
Size:
10,734 bases
Orientation:
Minus strand

Genomic View for BCL2L15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for BCL2L15 Gene

Proteins for BCL2L15 Gene

  • Protein details for BCL2L15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TBC7-B2L15_HUMAN
    Recommended name:
    Bcl-2-like protein 15
    Protein Accession:
    Q5TBC7
    Secondary Accessions:
    • A0PJY6
    • A8K074
    • I6LA82

    Protein attributes for BCL2L15 Gene

    Size:
    163 amino acids
    Molecular mass:
    17725 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2L15 Gene

Proteomics data for BCL2L15 Gene at MOPED

Post-translational modifications for BCL2L15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL2L15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BCL2L15 Gene

Domains & Families for BCL2L15 Gene

Gene Families for BCL2L15 Gene

Protein Domains for BCL2L15 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BCL2L15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCL2L15: view

No data available for UniProtKB/Swiss-Prot for BCL2L15 Gene

Function for BCL2L15 Gene

Gene Ontology (GO) - Molecular Function for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BCL2L15: view

Phenotypes for BCL2L15 Gene

GenomeRNAi human phenotypes for BCL2L15:
genes like me logo Genes that share phenotypes with BCL2L15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL2L15

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L15 Gene

Localization for BCL2L15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2L15 Gene COMPARTMENTS Subcellular localization image for BCL2L15 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with BCL2L15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL2L15 Gene

Pathways & Interactions for BCL2L15 Gene

SuperPathways for BCL2L15 Gene

No Data Available

Interacting Proteins for BCL2L15 Gene

Gene Ontology (GO) - Biological Process for BCL2L15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BCL2L15: view

No data available for Pathways by source and SIGNOR curated interactions for BCL2L15 Gene

Drugs & Compounds for BCL2L15 Gene

(1) Drugs for BCL2L15 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(2) Additional Compounds for BCL2L15 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LIPID
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with BCL2L15: view

Transcripts for BCL2L15 Gene

Unigene Clusters for BCL2L15 Gene

BCL2-like 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL2L15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L15 Gene

No ASD Table

Relevant External Links for BCL2L15 Gene

GeneLoc Exon Structure for
BCL2L15
ECgene alternative splicing isoforms for
BCL2L15

Expression for BCL2L15 Gene

mRNA expression in normal human tissues for BCL2L15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L15 Gene

This gene is overexpressed in Colon - Transverse (x16.3), Small Intestine - Terminal Ileum (x10.1), Pancreas (x6.3), and Stomach (x4.9).

Protein differential expression in normal tissues from HIPED for BCL2L15 Gene

This gene is overexpressed in Nasal epithelium (44.1) and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL2L15 Gene



SOURCE GeneReport for Unigene cluster for BCL2L15 Gene Hs.123106

genes like me logo Genes that share expression patterns with BCL2L15: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BCL2L15 Gene

Orthologs for BCL2L15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BCL2L15 35
  • 83.12 (n)
  • 76.87 (a)
BCL2L15 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL2L15 35
  • 86.3 (n)
  • 82.21 (a)
BCL2L15 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl2l15 35
  • 77.91 (n)
  • 71.17 (a)
Bcl2l15 16
Bcl2l15 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCL2L15 35
  • 99.39 (n)
  • 98.77 (a)
BCL2L15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl2l15 35
  • 78.4 (n)
  • 70.37 (a)
oppossum
(Monodelphis domestica)
Mammalia BCL2L15 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCL2L15 35
  • 55.94 (n)
  • 44.76 (a)
BCL2L15 36
  • 36 (a)
OneToOne
Species with no ortholog for BCL2L15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L15 Gene

ENSEMBL:
Gene Tree for BCL2L15 (if available)
TreeFam:
Gene Tree for BCL2L15 (if available)

Paralogs for BCL2L15 Gene

(1) SIMAP similar genes for BCL2L15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BCL2L15: view

No data available for Paralogs for BCL2L15 Gene

Variants for BCL2L15 Gene

Sequence variations from dbSNP and Humsavar for BCL2L15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_031475 -

Structural Variations from Database of Genomic Variants (DGV) for BCL2L15 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV Loss 19812545

Variation tolerance for BCL2L15 Gene

Residual Variation Intolerance Score: 57.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L15 Gene

HapMap Linkage Disequilibrium report
BCL2L15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L15 Gene

Disorders for BCL2L15 Gene

Relevant External Links for BCL2L15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L15
genes like me logo Genes that share disorders with BCL2L15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L15 Gene

Publications for BCL2L15 Gene

  1. Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. (PMID: 15961081) Dempsey C.E. … Renshaw S.A. (FEBS Lett. 2005) 2 23 67
  2. Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA. (PMID: 20046046) Isomoto H. … Hirayama T. (Tohoku J. Exp. Med. 2010) 23 67
  3. Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737. (PMID: 20307556) Young K.W. … Nicotera P. (Neuropharmacology 2010) 23 67
  4. HY253, a novel compound isolated from Aralia continentalis, induces apoptosis via cytochrome c-mediated intrinsic pathway in HeLa cells. (PMID: 19097782) Oh H.L. … Lee C.H. (Bioorg. Med. Chem. Lett. 2009) 23 67
  5. Molecular basis for Bcl-2 homology 3 domain recognition in the Bcl-2 protein family: identification of conserved hot spot interactions. (PMID: 19293158) Moroy G. … Stote R.H. (J. Biol. Chem. 2009) 23 67

Products for BCL2L15 Gene

Sources for BCL2L15 Gene

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