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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL2L15 Gene

protein-coding   GIFtS: 40
GCID: GC01M114419

BCL2-Like 15

(Previous name: chromosome 1 open reading frame 178)
(Previous symbol: C1orf178)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2-Like 151 2     Bcl-2-Like Protein 152
C1orf1781 2 3     bcl2-L-152
Chromosome 1 Open Reading Frame 1781     Pro-Apoptotic Bcl-2 Protein2
Bfk2     Bcl2-L-153

External Ids:    HGNC: 336241   Entrez Gene: 4406032   Ensembl: ENSG000001887617   UniProtKB: Q5TBC73   

Export aliases for BCL2L15 gene to outside databases

Previous GC identifers: GC01M114220 GC01M112277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BCL2L15 Gene: 
BCL2L15 (BCL2-like 15) is a protein-coding gene. Diseases associated with BCL2L15 include contagious pustular dermatitis, and rhinotracheitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL2L15 gene promoter:
         AML1a   GATA-3   HTF   Lmo2   RORalpha2   MEF-2A   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL2L15 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL2L15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2L15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

BCL2L15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L15 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M114419:  view genomic region     (about GC identifiers)

Start:
114,419,436 bp from pter      End:
114,430,169 bp from pter
Size:
10,734 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: B2L15_HUMAN, Q5TBC7 (See protein sequence)
Recommended Name: Bcl-2-like protein 15  
Size: 163 amino acids; 17725 Da
Secondary accessions: A0PJY6 A8K074 I6LA82
Alternative splicing: 2 isoforms:  Q5TBC7-1   Q5TBC7-2   (Pro-apoptotic when overexpressed)

Explore the universe of human proteins at neXtProt for BCL2L15: NX_Q5TBC7

Explore proteomics data for BCL2L15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TBC7

  • BCL2L15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCL2L15 Protein Expression
    REFSEQ proteins: NP_001010922.1  
    ENSEMBL proteins: 
     ENSP00000376992   ENSP00000376995   ENSP00000417458  

    Human Recombinant Protein Products for BCL2L15: 
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    Cloud-Clone Corp. Proteins for BCL2L15 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    BCL2L15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5TBC7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCL2L15 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BCL2L15

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    BCL2L15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCL2L15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCL2L15 (B2L15)

    3 Novoseek inferred chemical compound relationships for BCL2L15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 0.165 1 18291090 (1)
    oxygen 0 1 15601573 (1)
    calcium 0 1 17371290 (1)

    Search CenterWatch for drugs/clinical trials and news about BCL2L15 / B2L15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCL2L15 gene (4 alternative transcripts): 
    NM_001029944.1  NM_001029945.1  NM_001029946.1  NM_001010922.2  

    Unigene Cluster for BCL2L15:

    BCL2-like 15
    Hs.123106  [show with all ESTs]
    Unigene Representative Sequence: NM_001010922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369580(uc001edw.3 uc001edx.3 uc001edy.3) ENST00000393316(uc001edz.1)
    ENST00000488450 ENST00000393320 ENST00000471267 ENST00000486485
    miRNA
    Products:
         
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2L15 (see all 29):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-676 hsa-miR-125a-3p hsa-miR-3614-3p hsa-miR-216b hsa-miR-29b-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BCL2L15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2L15
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2L15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2L15

    Additional mRNA sequence: 

    AK026241.1 AK289439.1 AY265861.1 AY265862.1 AY265863.1 AY265864.1 BC127719.1 BC127720.1 
    BC132904.1 BC132906.1 

    6 DOTS entries:

    DT.75100992  DT.70101895  DT.99961115  DT.305715  DT.97824568  DT.75128994 

    24/25 AceView cDNA sequences (see all 25):

    BX091865 CB142909 AI821052 AW137209 AI802637 CR749373 BM829833 AW204165 
    CA312911 BF445012 AI821801 AW004997 AA594246 AI632962 BX091267 AA877677 
    BU607853 BM755890 AW138724 AI821221 AK026241 BX483608 BX644415 AA483638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL2L15 expression in normal human tissues (normalized intensities)      BCL2L15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATCGATA
    BCL2L15 Expression
    About this image


    BCL2L15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See BCL2L15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL2L15

    SOURCE GeneReport for Unigene cluster: Hs.123106
        SABiosciences Custom PCR Arrays for BCL2L15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2L15 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl2l151 , 5 BCLl2-like 151, 5 77.91(n)1
    71.17(a)1
      3 (45.52 cM)5
    2296721  NM_001142959.11  NP_001136431.11 
     1038326015 
    chicken
    (Gallus gallus)
    Aves BCL2L151 BCL2-like 15 54.34(n)
    41.78(a)
      772088  XM_001233930.2  XP_001233931.1 


    ENSEMBL Gene Tree for BCL2L15 (if available)
    TreeFam Gene Tree for BCL2L15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCL2L15 gene
    1 SIMAP similar gene for BCL2L15 using alignment to 2 protein entries:     B2L15_HUMAN (see all proteins):
    DKFZp779F1429

    BCL2L15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in BCL2L15 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0314754
    ----see VAR_0314752 D N mis40--------

    HapMap Linkage Disequilibrium report for BCL2L15 (114419436 - 114430169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BCL2L15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv23869CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for BCL2L15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    15 diseases for BCL2L15:    About MalaCards
    contagious pustular dermatitis    rhinotracheitis    drug-induced hepatitis    ischemia
    dermatitis    cervicitis    retinitis    hepatocellular carcinoma
    colorectal cancer    lung cancer    endotheliitis    hepatitis
    melanoma    neuronitis    breast cancer


    BCL2L15 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for BCL2L15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 10.4 3 9422523 (1), 17392282 (1), 17921043 (1)
    necrosis 8.96 2 17520191 (1), 17029566 (1)
    ischemia 0 1 19696224 (1)


    Export disorders for BCL2L15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL2L15 gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with BCL2L15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. (PubMed id 15961081)1, 2, 3, 9 Dempsey C.E....Renshaw S.A. (2005)
    2. Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization. (PubMed id 17412810)1, 3 Pujianto D.A....Poutanen M. (2007)
    3. Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. (PubMed id 16690252)1, 3 Luo H.Y....Li T.J. (2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region. (PubMed id 12700646)1, 3 Coultas L....Strasser A. (2003)
    7. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels. (PubMed id 17881896)9 Ewings K.E....Cook S.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440603 HGNC: 33624 AceView: LOC440603 Ensembl:ENSG00000188761 euGenes: HUgn440603
    ECgene: BCL2L15 H-InvDB: BCL2L15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL2L15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL2L15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCL2L15 gene:
    Search GeneIP for patents involving BCL2L15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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