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Aliases for BCL2L14 Gene

Aliases for BCL2L14 Gene

  • BCL2-Like 14 (Apoptosis Facilitator) 2 3
  • BCLG 3 4 6
  • Bcl2-L-14 3 4
  • Apoptosis Facilitator Bcl-2-Like Protein 14 3
  • Apoptosis Regulator BCL-G 3
  • Apoptosis Regulator Bcl-G 4

External Ids for BCL2L14 Gene

Previous GeneCards Identifiers for BCL2L14 Gene

  • GC12P012115
  • GC12P011989
  • GC12P012202

Summaries for BCL2L14 Gene

Entrez Gene Summary for BCL2L14 Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for BCL2L14 Gene

BCL2L14 (BCL2-Like 14 (Apoptosis Facilitator)) is a Protein Coding gene. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for BCL2L14 Gene

  • Plays a role in apoptosis

Gene Wiki entry for BCL2L14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L14 Gene

Genomics for BCL2L14 Gene

Regulatory Elements for BCL2L14 Gene

Transcription factor binding sites by QIAGEN in the BCL2L14 gene promoter:

Genomic Location for BCL2L14 Gene

12,049,844 bp from pter
12,211,084 bp from pter
161,241 bases
Plus strand

Genomic View for BCL2L14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL2L14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L14 Gene

Proteins for BCL2L14 Gene

  • Protein details for BCL2L14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apoptosis facilitator Bcl-2-like protein 14
    Protein Accession:
    Secondary Accessions:
    • A8KAD0
    • Q96QR5
    • Q9BZR7

    Protein attributes for BCL2L14 Gene

    327 amino acids
    Molecular mass:
    36598 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L14 Gene


neXtProt entry for BCL2L14 Gene

Proteomics data for BCL2L14 Gene at MOPED

Post-translational modifications for BCL2L14 Gene

  • Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for BCL2L14 Gene

Domains for BCL2L14 Gene

Gene Families for BCL2L14 Gene

Protein Domains for BCL2L14 Gene

Suggested Antigen Peptide Sequences for BCL2L14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Bcl-2 family.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L14: view

Function for BCL2L14 Gene

Molecular function for BCL2L14 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in apoptosis

Gene Ontology (GO) - Molecular Function for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11054413
GO:0019901 protein kinase binding IPI 17280616
genes like me logo Genes that share ontologies with BCL2L14: view

Phenotypes for BCL2L14 Gene

GenomeRNAi human phenotypes for BCL2L14:
genes like me logo Genes that share phenotypes with BCL2L14: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BCL2L14 Gene

Localization for BCL2L14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L14 Gene

Isoform 1: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Note=Predominantly localized to cytosolic organelles.

Subcellular locations from

Jensen Localization Image for BCL2L14 Gene COMPARTMENTS Subcellular localization image for BCL2L14 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 11054413
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0043229 intracellular organelle IDA 11054413
genes like me logo Genes that share ontologies with BCL2L14: view

Pathways for BCL2L14 Gene

SuperPathways for BCL2L14 Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with BCL2L14: view

Pathways by source for BCL2L14 Gene

1 BioSystems pathway for BCL2L14 Gene

Gene Ontology (GO) - Biological Process for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 17280616
GO:0042981 regulation of apoptotic process IEA --
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA 11054413
genes like me logo Genes that share ontologies with BCL2L14: view

Transcripts for BCL2L14 Gene

Unigene Clusters for BCL2L14 Gene

BCL2-like 14 (apoptosis facilitator):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL2L14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for BCL2L14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L14 Gene

mRNA expression in normal human tissues for BCL2L14 Gene

mRNA differential expression in normal tissues according to GTEx for BCL2L14 Gene

This gene is overexpressed in Testis (19.7), Colon - Transverse (10.8), Small Intestine - Terminal Ileum (5.2), and Stomach (5.0).

Protein differential expression in normal tissues for BCL2L14 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BCL2L14 Gene

SOURCE GeneReport for Unigene cluster for BCL2L14 Gene Hs.210343

mRNA Expression by UniProt/SwissProt for BCL2L14 Gene

Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is testis-specific.
genes like me logo Genes that share expressions with BCL2L14: view

Expression partners for BCL2L14 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BCL2L14 Gene

Orthologs for BCL2L14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BCL2L14 35
  • 78.05 (n)
  • 68.63 (a)
BCL2L14 36
  • 61 (a)
(Canis familiaris)
Mammalia BCL2L14 35
  • 79.14 (n)
  • 69.02 (a)
BCL2L14 36
  • 68 (a)
(Mus musculus)
Mammalia Bcl2l14 35
  • 77.43 (n)
  • 69.57 (a)
Bcl2l14 16
Bcl2l14 36
  • 68 (a)
(Pan troglodytes)
Mammalia BCL2L14 35
  • 98.88 (n)
  • 97.86 (a)
BCL2L14 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Bcl2l14 35
  • 77.16 (n)
  • 69.44 (a)
(Gallus gallus)
Aves BCL2L14 35
  • 50.22 (n)
  • 33.55 (a)
BCL2L14 36
  • 28 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732952 35
  • 55.19 (n)
  • 40.16 (a)
(Danio rerio)
Actinopterygii CABZ01020840.1 36
  • 22 (a)
Species with no ortholog for BCL2L14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL2L14 Gene

Gene Tree for BCL2L14 (if available)
Gene Tree for BCL2L14 (if available)

Paralogs for BCL2L14 Gene

(1) SIMAP similar genes for BCL2L14 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with BCL2L14: view

No data available for Paralogs for BCL2L14 Gene

Variants for BCL2L14 Gene

Sequence variations from dbSNP and Humsavar for BCL2L14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs879732 -- 12,087,265(+) GTTTA(C/T)TCCTG reference, synonymous-codon
rs884139 -- 12,095,363(-) AAATG(C/T)CATGA intron-variant
rs885636 -- 12,095,596(+) TACTA(C/G)CCCAC intron-variant
rs885637 -- 12,095,346(+) ATGCA(A/G)AGACT intron-variant
rs885720 -- 12,095,165(+) ATGGA(A/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L14 Gene

Variant ID Type Subtype PubMed ID
esv2676351 CNV Deletion 23128226

Relevant External Links for BCL2L14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L14 Gene

Disorders for BCL2L14 Gene

Relevant External Links for BCL2L14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for BCL2L14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BCL2L14 Gene

Publications for BCL2L14 Gene

  1. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. (PMID: 11054413) Guo B. … Reed J.C. (J. Biol. Chem. 2001) 2 3 4
  2. Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia. (PMID: 15284860) Montpetit A. … Sinnett D. (Leukemia 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. (PMID: 17280616) Lin M.L. … Katagiri T. (Breast Cancer Res. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for BCL2L14 Gene

Sources for BCL2L14 Gene

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