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Aliases for BCL2L14 Gene

Aliases for BCL2L14 Gene

  • BCL2 Like 14 2 3 5
  • BCL2-Like 14 (Apoptosis Facilitator) 2 3
  • Bcl2-L-14 3 4
  • BCLG 3 4
  • Apoptosis Facilitator Bcl-2-Like Protein 14 3
  • Testicular Tissue Protein Li 26 3
  • Apoptosis Regulator BCL-G 3
  • Apoptosis Regulator Bcl-G 4

External Ids for BCL2L14 Gene

Previous GeneCards Identifiers for BCL2L14 Gene

  • GC12P012115
  • GC12P011989
  • GC12P012202

Summaries for BCL2L14 Gene

Entrez Gene Summary for BCL2L14 Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for BCL2L14 Gene

BCL2L14 (BCL2 Like 14) is a Protein Coding gene. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene Expression. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for BCL2L14 Gene

  • Plays a role in apoptosis.

Gene Wiki entry for BCL2L14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L14 Gene

Genomics for BCL2L14 Gene

Regulatory Elements for BCL2L14 Gene

Enhancers for BCL2L14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F011742 1.7 FANTOM5 Ensembl ENCODE 25.5 -297.9 -297876 18.3 HDGF PKNOX1 ATF1 WRNIP1 ELK1 ZNF207 ZNF548 JUNB TBX21 SREBF1 ETV6 BCL2L14 TAS2R43 TAS2R20 TAS2R50 ENSG00000256981 ENSG00000256682 TAS2R14 DDX55P1 LINC01252
GH12F011808 1.5 FANTOM5 Ensembl ENCODE 21.4 -237.6 -237564 7.0 SOX13 CTCF TBP WRNIP1 JUN SIN3A DMAP1 RAD21 RELA ZNF366 BCL2L14 ETV6 TAS2R43 TAS2R20 TAS2R50 ENSG00000256981 ENSG00000256682 GC12M011721 PIR45971
GH12F011828 1.6 FANTOM5 Ensembl ENCODE 19.4 -214.8 -214820 12.2 HDGF TBP HDAC1 PKNOX1 WRNIP1 BMI1 RAD21 ZNF416 FOS ETV6 ETV6 BCL2L14 PIR45971 GC12M011721
GH12F011821 1.5 FANTOM5 Ensembl ENCODE 20.4 -224.9 -224856 7.3 HDGF TBP PKNOX1 WRNIP1 BMI1 ZBTB40 ZNF121 CBX5 ETV6 CREM BCL2L14 ETV6 TAS2R19 GC12M011721 PIR45971
GH12F011880 1.1 FANTOM5 Ensembl 19.4 -169.3 -169319 0.3 ELF3 CTCF LEF1 ZNF2 RAD21 ZNF101 ZBTB48 SCRT2 EED ZNF143 BCL2L14 ETV6 PIR45971 GC12M011721
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCL2L14 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BCL2L14 gene promoter:

Genomic Location for BCL2L14 Gene

12,049,844 bp from pter
12,211,084 bp from pter
161,241 bases
Plus strand

Genomic View for BCL2L14 Gene

Genes around BCL2L14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L14 Gene

Proteins for BCL2L14 Gene

  • Protein details for BCL2L14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apoptosis facilitator Bcl-2-like protein 14
    Protein Accession:
    Secondary Accessions:
    • A8KAD0
    • Q96QR5
    • Q9BZR7

    Protein attributes for BCL2L14 Gene

    327 amino acids
    Molecular mass:
    36598 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L14 Gene


neXtProt entry for BCL2L14 Gene

Post-translational modifications for BCL2L14 Gene

  • Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for BCL2L14 Gene

Domains & Families for BCL2L14 Gene

Gene Families for BCL2L14 Gene

Protein Domains for BCL2L14 Gene

Suggested Antigen Peptide Sequences for BCL2L14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Bcl-2 family.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L14: view

Function for BCL2L14 Gene

Molecular function for BCL2L14 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in apoptosis.

Gene Ontology (GO) - Molecular Function for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11054413
GO:0019901 protein kinase binding IPI 17280616
genes like me logo Genes that share ontologies with BCL2L14: view
genes like me logo Genes that share phenotypes with BCL2L14: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L14 Gene

Localization for BCL2L14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L14 Gene

Isoform 1: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Note=Predominantly localized to cytosolic organelles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L14 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0043229 intracellular organelle IDA 11054413
genes like me logo Genes that share ontologies with BCL2L14: view

Pathways & Interactions for BCL2L14 Gene

genes like me logo Genes that share pathways with BCL2L14: view

Gene Ontology (GO) - Biological Process for BCL2L14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA,IDA 17280616
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with BCL2L14: view

No data available for SIGNOR curated interactions for BCL2L14 Gene

Transcripts for BCL2L14 Gene

Unigene Clusters for BCL2L14 Gene

BCL2-like 14 (apoptosis facilitator):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for BCL2L14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCL2L14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L14 Gene

This gene is overexpressed in Testis (x19.7), Colon - Transverse (x10.8), Small Intestine - Terminal Ileum (x5.2), and Stomach (x5.0).

Protein differential expression in normal tissues from HIPED for BCL2L14 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCL2L14 Gene

Protein tissue co-expression partners for BCL2L14 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL2L14 Gene:


SOURCE GeneReport for Unigene cluster for BCL2L14 Gene:


mRNA Expression by UniProt/SwissProt for BCL2L14 Gene:

Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is testis-specific.
genes like me logo Genes that share expression patterns with BCL2L14: view

Orthologs for BCL2L14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCL2L14 34 35
  • 98.88 (n)
(Canis familiaris)
Mammalia BCL2L14 34 35
  • 79.14 (n)
(Bos Taurus)
Mammalia BCL2L14 34 35
  • 78.05 (n)
(Mus musculus)
Mammalia Bcl2l14 34 16 35
  • 77.43 (n)
(Rattus norvegicus)
Mammalia Bcl2l14 34
  • 77.16 (n)
(Gallus gallus)
Aves BCL2L14 34 35
  • 50.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732952 34
  • 55.19 (n)
(Danio rerio)
Actinopterygii CABZ01020840.1 35
  • 22 (a)
Species where no ortholog for BCL2L14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL2L14 Gene

Gene Tree for BCL2L14 (if available)
Gene Tree for BCL2L14 (if available)

Paralogs for BCL2L14 Gene

(1) SIMAP similar genes for BCL2L14 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with BCL2L14: view

No data available for Paralogs for BCL2L14 Gene

Variants for BCL2L14 Gene

Sequence variations from dbSNP and Humsavar for BCL2L14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10082709 -- 12,090,649(+) aataa(A/T)aaaaa intron-variant
rs10129033 -- 12,098,444(+) ATGTT(A/C)AGCCA intron-variant
rs10492119 -- 12,086,560(+) CTTTT(A/C/G/T)TCAGC intron-variant
rs10538473 -- 12,074,981(+) CATAC(-/ACTGT)ACTGT intron-variant
rs10716109 -- 12,078,404(+) CCTTT(-/A)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L14 Gene

Variant ID Type Subtype PubMed ID
nsv557583 CNV gain 21841781
nsv1046355 CNV loss 25217958
esv7410 CNV loss 19470904
esv3628598 CNV loss 21293372
esv2676351 CNV deletion 23128226

Variation tolerance for BCL2L14 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L14 Gene

Disorders for BCL2L14 Gene

Relevant External Links for BCL2L14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BCL2L14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L14 Gene

Publications for BCL2L14 Gene

  1. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. (PMID: 11054413) Guo B. … Reed J.C. (J. Biol. Chem. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly J.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for BCL2L14 Gene

Sources for BCL2L14 Gene

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