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BCL2L13 Gene

protein-coding   GIFtS: 58
GCID: GC22P018111

BCL2-Like 13 (Apoptosis Facilitator)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
BCL2-Like 13 (Apoptosis Facilitator)1 2     Bcl-2-Like Protein 132
Bcl2-L-132 3     Bcl-rambo3
MIL12 3     Protein Mil13
BCL-RAMBO2     

External Ids:    HGNC: 171641   Entrez Gene: 237862   Ensembl: ENSG000000999687   UniProtKB: Q9BXK53   
ORGUL members:         

Export aliases for BCL2L13 gene to outside databases

Previous GC identifers: GC22P015052 GC22P016486 GC22P016496 GC22P001936


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCL2L13 Gene:
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs.
Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been
observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for BCL2L13 Gene:
BCL2L13 (BCL2-like 13 (apoptosis facilitator)) is a protein-coding gene. Diseases associated with BCL2L13 include cat eye syndrome, and b-cell lymphomas. GO annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process.

UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5
Function: May promote the activation of caspase-3 and apoptosis

Gene Wiki entry for BCL2L13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_187355.1  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCL2L13 gene promoter:
         AhR   NF-YA   Egr-1   Arnt   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCL2L13 promoter sequence
   Search Chromatin IP Primers for BCL2L13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL2L13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11

BCL2L13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L13 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P018111:  view genomic region     (about GC identifiers)

Start:
18,111,621 bp from pter      End:
18,213,388 bp from pter
Size:
101,768 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5 (See protein sequence)
Recommended Name: Bcl-2-like protein 13  
Size: 485 amino acids; 52723 Da
Subunit: Monomer (Probable)
Sequence caution: Sequence=AAF03602.1; Type=Erroneous initiation; Sequence=AAG09680.1; Type=Frameshift;
Positions=Several;
1 PDB 3D structure from and Proteopedia for BCL2L13:
2IPD (3D)    
Secondary accessions: B3KPE7 Q96B37 Q96IB7 Q9BY01 Q9HC05 Q9UFE0 Q9UKN3
Alternative splicing: 3 isoforms:  Q9BXK5-1   Q9BXK5-2   Q9BXK5-4   

Explore the universe of human proteins at neXtProt for BCL2L13: NX_Q9BXK5

Explore proteomics data for BCL2L13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys450
  • Modification sites at PhosphoSitePlus

  • See BCL2L13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001257655.1  NP_001257656.1  NP_001257657.1  NP_001257658.1  NP_001257659.1  NP_001257660.1  NP_001257661.1  NP_001257662.1  
    NP_001257663.1  NP_001257664.1  NP_056182.2  

    ENSEMBL proteins: 
     ENSP00000382682   ENSP00000318883   ENSP00000436321   ENSP00000434764   ENSP00000347133  
     ENSP00000382677   ENSP00000410019   ENSP00000441344   ENSP00000437667   ENSP00000338932  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002475 Bcl2-like
     IPR026298 Blc2_fam

    Graphical View of Domain Structure for InterPro Entry Q9BXK5

    ProtoNet protein and cluster: Q9BXK5

    2 Blocks protein domains:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5
    Similarity: Belongs to the Bcl-2 family


    BCL2L13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B2L13_HUMAN, Q9BXK5
    Function: May promote the activation of caspase-3 and apoptosis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process NAS11262395
         
    BCL2L13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL2L13:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL2L13
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    miRNA
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    miRTarBase miRNAs that target BCL2L13:
    hsa-mir-34a-5p (MIRT025555), hsa-mir-1301-3p (MIRT036025), hsa-mir-10a-5p (MIRT025589), hsa-mir-125b-5p (MIRT046068), hsa-mir-192-5p (MIRT026746), hsa-mir-215-5p (MIRT024899)

    Block miRNA regulation of human, mouse, rat BCL2L13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL2L13 (see all 23):
    hsa-miR-548j hsa-miR-137 hsa-miR-548i hsa-miR-548k hsa-miR-1271 hsa-miR-624 hsa-miR-3162-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidBCL2L13 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BCL2L13

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B2L13_HUMAN, Q9BXK5: Isoform 2: Mitochondrion membrane; Single-pass membrane protein (Potential). Nucleus
    (Probable)
    B2L13_HUMAN, Q9BXK5: Isoform 1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    cytosol2
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion NAS11262395
    GO:0016021integral component of membrane IDA11262395
    GO:0031966mitochondrial membrane IEA--

    BCL2L13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCL2L13 About    
    See pathways by source

    SuperPathContained pathways About
    1Legionellosis
    Legionellosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for BCL2L13):
        Legionellosis


    BCL2L13 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including BCL2L13: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL2L13

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for BCL2L13 (Q9BXK52, 3 ENSP000003188834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605203, ENSP000000372434I2D: score=4 STRING: ENSP00000037243
    HSPD1P108092MINT-8391250
    SLC25A4P122352MINT-8391231
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS11262395
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process NAS11262395
    GO:0042981regulation of apoptotic process ----

    BCL2L13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCL2L13 (B2L13)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BCL2L13 gene (11 alternative transcripts): 
    NM_001270726.1  NM_001270727.1  NM_001270728.1  NM_001270729.1  NM_001270730.1  NM_001270731.1  NM_001270732.1  NM_001270733.1  
    NM_001270734.1  NM_001270735.1  NM_015367.3  

    Unigene Cluster for BCL2L13:

    BCL2-like 13 (apoptosis facilitator)
    Hs.631672  [show with all ESTs]
    Unigene Representative Sequence: NM_015367
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399781 ENST00000399782(uc002zmu.3) ENST00000317582 ENST00000498133
    ENST00000464649 ENST00000493680 ENST00000355028(uc002zmw.3 uc002zmx.3 uc002zmy.3 uc010gqy.3 uc011agk.2 uc010gqz.3 uc002zmz.3 uc002zna.3)
    ENST00000399777 ENST00000479296 ENST00000485631 ENST00000418951 ENST00000538149
    ENST00000543133 ENST00000337612
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BCL2L13 (see all 23):
    hsa-miR-548j hsa-miR-137 hsa-miR-548i hsa-miR-548k hsa-miR-1271 hsa-miR-624 hsa-miR-3162-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidBCL2L13 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: BCL2L13 (NM_015367)
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    OriGene qPCR primer pairs and template standards for BCL2L13
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCL2L13
      QuantiTect SYBR Green Assays in human, mouse, rat BCL2L13
      QuantiFast Probe-based Assays in human, mouse, rat BCL2L13

    Additional mRNA sequence: 

    AF086412.1 AF146568.1 AF246665.1 AF325209.1 AF539453.1 AK027443.1 AK056248.1 AK075044.1 
    AK291449.1 AK294286.1 AK301394.1 AK314489.1 AL133029.1 AL831982.2 BC003032.1 BC007658.2 
    BC016037.1 CR456521.1 NR_073068.1 NR_073069.1 

    Selected DOTS entries (see all 35):

    DT.116941  DT.100060839  DT.100036828  DT.100060841  DT.100661063  DT.120653579  DT.100882422  DT.120653493 
    DT.95262744  DT.120653518  DT.97848973  DT.100882415  DT.92055018  DT.100882414  DT.402888  DT.100882417 
    DT.100882427  DT.120653520  DT.120653572  DT.100882426  DT.120653494  DT.120653501  DT.92409517  DT.100705108 

    Selected AceView cDNA sequences (see all 393):

    AI283481 BX357428 BM712483 BG742753 AF325209 BG034549 AI810309 BC007658 
    BU179480 BM910427 AI985843 AA349543 AI368149 BQ049592 BM761914 CR602532 
    BC003032 BX402375 AI290409 CD369228 BX379504 AF246665 AA928129 AW769004 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L13 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
    SP1:                                                  -                       -                 -                       -     -     -     -                     
    SP2:                    -     -     -     -     -     -                       -                 -                                                               
    SP3:                                                  -                       -                 -     -                 -     -     -     -                     
    SP4:                                                  -                       -                 -                                                               
    SP5:                                                  -     -     -     -     -                 -                       -     -     -     -                     

    ExUns: 14d · 14e · 14f · 14g · 14h · 14i
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for BCL2L13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCL2L13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGAGGGCC
    BCL2L13 Expression
    About this image

    BCL2L13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL2L13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631672

    UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5
    Tissue specificity: Ubiquitous, with the highest levels of expression in heart, placenta and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including BCL2L13: 
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat BCL2L13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2L13 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl2l131 , 5 BCL2-like 13 (apoptosis facilitator)1, 5 80.03(n)1
    76.73(a)1
      6 (57.01 cM)5
    940441  NM_153516.21  NP_705736.11 
     1208362305 
    chicken
    (Gallus gallus)
    Aves BCL2L131 BCL2-like 13 (apoptosis facilitator) 68.74(n)
    70.82(a)
      418163  XM_416394.4  XP_416394.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL2L136
    BCL2-like 13 (apoptosis facilitator)
    66(a)
    1 ↔ 1
    5(14030402-14054633)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.9492 Transcribed sequence with weak similarity to protein more 76.54(n)    AL970202.2 
    zebrafish
    (Danio rerio)
    Actinopterygii bcl2l131 BCL2-like 13 (apoptosis facilitator) 53.86(n)
    51.69(a)
      559355  NM_001044891.2  NP_001038356.1 


    ENSEMBL Gene Tree for BCL2L13 (if available)
    TreeFam Gene Tree for BCL2L13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCL2L13 gene
    8 SIMAP similar genes for BCL2L13 using alignment to 7 protein entries:     B2L13_HUMAN (see all proteins):
    DKFZp451F173    NSD1    PSD3    HGSNAT    KLHDC1    WDR6
    ZNHIT3    IFT122

    BCL2L13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCL2L13 (see all 2213)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922635521,2
    --18119404(+) ACAAAA/GAAAAA 10 -- us2k10--------
    rs1133761871,2
    C--18119456(+) ACTCAG/CGAGGC 10 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs96053561,2
    C,F--18119476(+) agaatC/Tgcttg 10 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1501462141,2
    --18119494(+) GAGGTG/TAGGTT 10 -- us2k10--------
    rs96053571,2
    C,F,A--18119516(+) gatcgC/Tgccat 10 -- us2k12Minor allele frequency- T:0.50NA CSA 4
    rs1839817481,2
    --18119721(+) GTACAC/TACAGT 10 -- us2k10--------
    rs668382411,2
    C--18119761(+) GGGCCG/AGGCGC 10 -- us2k13Minor allele frequency- A:0.14NA 124
    rs713282281,2
    C--18119773(+) GTGGCA/GCACCC 10 -- us2k12Minor allele frequency- G:0.25NA 4
    rs121576421,2
    C,F,A--18119777(+) cgcacG/Ccctgt 10 -- us2k15Minor allele frequency- C:0.33NA CSA 9
    rs1383405961,2
    --18119870(+) CCCGTC/TTCTAT 10 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCL2L13 (18111621 - 18213388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BCL2L13 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660619CNV Deletion23128226
    esv2669345CNV Deletion23128226
    nsv820926CNV Deletion20802225
    esv2723953CNV Deletion23290073
    esv2673622CNV Deletion23128226
    esv2665896CNV Deletion23128226
    esv1008890CNV Deletion20482838
    nsv828930CNV Loss20364138
    nsv914152CNV Loss21882294
    nsv524899CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL2L13
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL2L13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    16 diseases for BCL2L13:    
    About MalaCards
    cat eye syndrome    b-cell lymphomas    churg-strauss syndrome    cowpox
    legionellosis    leukemia/lymphoma, t-cell    liposarcoma    non-hodgkin lymphoma
    hodgkin's lymphoma    lymphoblastic leukemia    hepatitis b    leukemia
    hepatitis    prostate cancer    breast cancer    prostatitis


    BCL2L13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BCL2L13
    Human Genome Epidemiology (HuGE) Navigator: BCL2L13 (6 documents)

    Export disorders for BCL2L13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCL2L13 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with BCL2L13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. (PubMed id 11381032)1, 2, 3 Footz T.K....McDermid H.E. (Genome Res. 2001)
    2. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. (PubMed id 11262395)1, 2, 3 Kataoka T....Tschopp J. (J. Biol. Chem. 2001)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    6. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1, 2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23786 HGNC: 17164 AceView: BCL2L13 Ensembl:ENSG00000099968 euGenes: HUgn23786
    ECgene: BCL2L13 Kegg: 23786 H-InvDB: BCL2L13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BCL2L13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCL2L13 gene:
    Search GeneIP for patents involving BCL2L13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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