Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL2L13 Gene

protein-coding   GIFtS: 54
GCID: GC22P018111

BCL2-like 13 (apoptosis facilitator)

 Explore 16 diseases affiliated with
BCL2L13 via our new
 Human Malady Compendium 
Biological research products
for BCL2L13
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
BCL2-Like 13 (Apoptosis Facilitator)1 2     Bcl-2-Like Protein 132
MIL11 2 3     Bcl-Rambo1
BCL-RAMBO1 2     Protein Mil13
Bcl2-L-132 3     

External Ids:    HGNC: 171641   Entrez Gene: 237862   Ensembl: ENSG000000999687   UniProtKB: Q9BXK53   

Export aliases for BCL2L13 gene to outside databases

Previous GC identifers: GC22P015052 GC22P016486 GC22P016496 GC22P001936


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2L13:
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression
of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this
gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5
Function: May promote the activation of caspase-3 and apoptosis

Gene Wiki entry for BCL2L13


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL2L13 gene promoter:
         AhR   NF-YA   Egr-1   Arnt   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCL2L13 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL2L13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2L13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11

BCL2L13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L13 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P018111:  view genomic region     (about GC identifiers)

Start:
18,111,621 bp from pter      End:
18,213,388 bp from pter
Size:
101,768 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5 (See protein sequence)
Recommended Name: Bcl-2-like protein 13  
Size: 485 amino acids; 52723 Da
Subunit: Monomer (Probable)
Subcellular location: Isoform 2: Mitochondrion membrane; Single-pass membrane protein (Potential). Nucleus (Probable)
Subcellular location: Isoform 1: Nucleus (Probable)
Sequence caution: Sequence=AAF03602.1; Type=Erroneous initiation; Sequence=AAG09680.1; Type=Frameshift;
Positions=Several;
1 PDB 3D structure from and Proteopedia for BCL2L13:
2IPD (3D)    
Secondary accessions: Q96B37 Q96IB7 Q9BY01 Q9HC05 Q9UFE0 Q9UKN3
Alternative splicing: 2 isoforms:  Q9BXK5-1   Q9BXK5-2   

Explore the universe of human proteins at neXtProt for BCL2L13: NX_Q9BXK5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BXK5

  • BCL2L13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (11 alternative transcripts): 
    NP_001257655.1  NP_001257656.1  NP_001257657.1  NP_001257658.1  NP_001257659.1  NP_001257660.1  NP_001257661.1  NP_001257662.1  
    NP_001257663.1  NP_001257664.1  NP_056182.2  

    ENSEMBL proteins: 
     ENSP00000382682   ENSP00000318883   ENSP00000436321   ENSP00000434764   ENSP00000347133  
     ENSP00000382677   ENSP00000410019   ENSP00000441344   ENSP00000437667   ENSP00000338932  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: BCL2L13
    OriGene Protein Over-expression Lysate: BCL2L13
    OriGene Custom Protein Services for BCL2L13 
    GenScript Custom Purified and Recombinant Proteins Services for BCL2L13
    Novus Biologicals BCL2L13 Proteins
    Novus Biologicals BCL2L13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BCL2L13

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion NAS11262395
    GO:0016021integral to membrane IDA11262395
    GO:0031966mitochondrial membrane IEA--


    BCL2L13 for ontologies           About GeneDecksing



    BCL2L13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: BCL2L13
    OriGene Custom Antibody Services for BCL2L13 
    GenScript Custom Superior Antibodies Services for BCL2L13
    Novus Biologicals BCL2L13 Antibodies
    Abcam antibodies for BCL2L13 
    Uscn Antibodies for BCL2L13
    ThermoFisher Antibodies for BCL2L13

    Assay Products for BCL2L13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCL2L13
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BCL2L13


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BCL2L13 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002475 Bcl2-like
     IPR026298 Blc2_fam

    Graphical View of Domain Structure for InterPro Entry Q9BXK5

    ProtoNet protein and cluster: Q9BXK5

    2 Blocks protein families:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5
    Similarity: Belongs to the Bcl-2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5
    Function: May promote the activation of caspase-3 and apoptosis

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: BCL2L13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2L13
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2L13 (see all 23):
    hsa-miR-548j hsa-miR-137 hsa-miR-548i hsa-miR-548k hsa-miR-1271 hsa-miR-624 hsa-miR-3162-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidBCL2L13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2L13 (see all 7)
    OriGene shRNA RFP: BCL2L13
    OriGene siRNA: BCL2L13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2L13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCL2L13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2L13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2L13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BCL2L13 (NM_015367)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2L13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2L13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCL2L13
    Search LifeMap BioReagents cell lines for BCL2L13

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L13

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process NAS11262395


    BCL2L13 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BCL2L13:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL2L13

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for BCL2L13 (Q9BXK52, 3 ENSP000003188834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605203, ENSP000000372434I2D: score=4 STRING: ENSP00000037243
    HSPD1P108092MINT-8391250
    SLC25A4P122352MINT-8391231
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006917induction of apoptosis NAS11262395
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process NAS11262395
    GO:0042981regulation of apoptotic process ----


    BCL2L13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCL2L13
    Search CenterWatch for drugs/clinical trials and news about BCL2L13 / B2L13 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCL2L13 gene (11 alternative transcripts): 
    NM_001270726.1  NM_001270727.1  NM_001270728.1  NM_001270729.1  NM_001270730.1  NM_001270731.1  NM_001270732.1  NM_001270733.1  
    NM_001270734.1  NM_001270735.1  NM_015367.3  

    Unigene Cluster for BCL2L13:

    BCL2-like 13 (apoptosis facilitator)
    Hs.631672  [show with all ESTs]
    Unigene Representative Sequence: NM_015367
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399781 ENST00000399782(uc002zmu.3) ENST00000317582 ENST00000498133
    ENST00000464649 ENST00000493680 ENST00000355028(uc002zmw.3 uc002zmx.3 uc002zmy.3 uc010gqy.3 uc011agk.2 uc010gqz.3 uc002zmz.3 uc002zna.3)
    ENST00000399777 ENST00000479296 ENST00000485631 ENST00000418951 ENST00000538149
    ENST00000543133 ENST00000337612

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: BCL2L13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2L13
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2L13 (see all 23):
    hsa-miR-548j hsa-miR-137 hsa-miR-548i hsa-miR-548k hsa-miR-1271 hsa-miR-624 hsa-miR-3162-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidBCL2L13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2L13 (see all 7)
    OriGene shRNA RFP: BCL2L13
    OriGene siRNA: BCL2L13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2L13
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2L13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2L13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BCL2L13 (NM_015367)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2L13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2L13 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2L13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCL2L13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2L13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2L13

    Additional cDNA sequence: 

    AF086412.1 AF146568.1 AF246665.1 AF325209.1 AF539453.1 AK027443.1 AK056248.1 AK075044.1 
    AK291449.1 AK294286.1 AK301394.1 AK314489.1 AL133029.1 AL831982.2 BC003032.1 BC007658.2 
    BC016037.1 CR456521.1 NR_073068.1 NR_073069.1 

    24/35 DOTS entries (see all 35):

    DT.116941  DT.100060839  DT.100036828  DT.100060841  DT.100661063  DT.120653579  DT.100882422  DT.120653493 
    DT.95262744  DT.120653518  DT.97848973  DT.100882415  DT.92055018  DT.100882414  DT.402888  DT.100882417 
    DT.100882427  DT.120653520  DT.120653572  DT.100882426  DT.120653494  DT.120653501  DT.92409517  DT.100705108 

    24/393 AceView cDNA sequences (see all 393):

    BE293272 BQ720818 BM726667 BM761914 BM672198 BM687928 AI364348 BM767112 
    BQ049592 BM910427 BM767486 BU730017 BQ958582 AI566619 NM_015367 BU179480 
    CA446170 AI831026 AA928129 BU155651 AA037409 BX402374 AA226881 BG034549 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L13 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ·
    SP1:                                                  -                       -                 -                       -     -     -     -                     
    SP2:                    -     -     -     -     -     -                       -                 -                                                               
    SP3:                                                  -                       -                 -     -                 -     -     -     -                     
    SP4:                                                  -                       -                 -                                                               
    SP5:                                                  -     -     -     -     -                 -                       -     -     -     -                     

    ExUns: 14d · 14e · 14f · 14g · 14h · 14i
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for BCL2L13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL2L13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCGAGGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See BCL2L13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL2L13

    SOURCE GeneReport for Unigene cluster: Hs.631672

    UniProtKB/Swiss-Prot: B2L13_HUMAN, Q9BXK5
    Tissue specificity: Ubiquitous, with the highest levels of expression in heart, placenta and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including BCL2L13: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2L13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCL2L13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2L13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2L13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2L13 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl2l131 , 5 BCL2-like 13 (apoptosis facilitator)1, 5 79.72(n)1
    76.73(a)1
      6 (57.01 cM)5
    940441  NM_153516.21  NP_705736.11 
     1208362305 
    chicken
    (Gallus gallus)
    Aves BCL2L131 BCL2-like 13 (apoptosis facilitator) 69.31(n)
    71.67(a)
      418163  XM_416394.3  XP_416394.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL2L136
    --
    72(a)
    1 ↔ 1
    5(14030460-14054437)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.9492 Transcribed sequence with weak similarity to protein more 76.54(n)    AL970202.2 
    zebrafish
    (Danio rerio)
    Actinopterygii bcl2l131 BCL2-like 13 (apoptosis facilitator) 53.63(n)
    50.44(a)
      559355  NM_001044891.2  NP_001038356.1 


    ENSEMBL Gene Tree for BCL2L13 (if available)
    TreeFam Gene Tree for BCL2L13 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1882 NCBI SNPs in BCL2L13 are shown (see all 1882    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922635521,2
    --18119404(+) ACAAAA/GAAAAA 10 -- us2k10--------
    rs1133761871,2
    --18119456(+) ACTCAG/CGAGGC 10 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs96053561,2
    C,--18119476(+) agaatC/Tgcttg 10 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1501462141,2
    --18119494(+) GAGGTG/TAGGTT 10 -- us2k10--------
    rs96053571,2
    F,A,--18119516(+) gatcgC/Tgccat 10 -- us2k12Minor allele frequency- T:0.50NA CSA 4
    rs1839817481,2
    --18119721(+) GTACAC/TACAGT 10 -- us2k10--------
    rs668382411,2
    C,--18119761(+) GGGCCG/AGGCGC 10 -- us2k13Minor allele frequency- A:0.14NA 124
    rs713282281,2
    C,--18119773(+) GTGGCA/GCACCC 10 -- us2k12Minor allele frequency- G:0.25NA 4
    rs121576421,2
    C,F,A,--18119777(+) CGCACG/CCCTGT 10 -- us2k15Minor allele frequency- C:0.33NA CSA 9
    rs1383405961,2
    --18119870(+) CCCGTC/TTCTAT 10 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCL2L13 (18111621 - 18213388 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for BCL2L13
         4 CNVs: 67830 79424 90862 67829
         2 Indels: 79423 79425

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2L13
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL2L13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BCL2L13 for disorders           About GeneDecksing

    16 diseases for BCL2L13:    About MalaCards
    b-cell lymphomas    cat eye syndrome    non-hodgkin lymphoma    hodgkin's lymphoma
    acute lymphoblastic leukemia    lymphoblastic leukemia    cowpox    hepatitis b
    leukemia    hepatitis    prostatitis    churg-strauss syndrome
    leukemia/lymphoma, t-cell    leukemia/lymphoma    liposarcoma    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: BCL2L13 (6 documents)

    Export disorders for BCL2L13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL2L13 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with BCL2L13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. (PubMed id 11381032)1, 2, 3 Footz T.K....McDermid H.E. (2001)
    2. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. (PubMed id 11262395)1, 2, 3 Kataoka T....Tschopp J. (2001)
    3. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (2008)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1, 2 Bechtel S.... Schupp I. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. Bcl-rambo induces apoptosis via interaction with the a denine nucleotide translocator. (PubMed id 22921587)1 Kim J.Y....Park J.H. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23786 HGNC: 17164 AceView: BCL2L13 Ensembl:ENSG00000099968 euGenes: HUgn23786
    ECgene: BCL2L13 H-InvDB: BCL2L13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL2L13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCL2L13 gene:
    Search GeneIP for patents involving BCL2L13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for BCL2L13   OriGene shRNA RFP for BCL2L13  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2L13   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2L13  
     OriGene Protein Over-expression Lysate for BCL2L13   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BCL2L13   OriGene 3'-UTR Clone for BCL2L13  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2L13   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2L13  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for BCL2L13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCL2L13   OriGene Custom Protein Services for BCL2L13  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCL2L13
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2L13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2L13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2L13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2L13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2L13
     GenScript Custom Purified and Recombinant Proteins Services for BCL2L13 GenScript cDNA clones with any tag delivered in your preferred vector for BCL2L13
     GenScript Custom Assay Services for BCL2L13 GenScript Custom Superior Antibodies Services for BCL2L13
     GenScript Custom overexpressing Cell Line Services for BCL2L13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BCL2L13 promoter
     Search Chromatin IP Primers for BCL2L13
     RT2 qPCR Primer Assay in human, mouse, rat BCL2L13
     GNC Network for BCL2L13
     SABiosciences PCR Arrays including human, mouse, rat BCL2L13
     Search Tocris compounds for BCL2L13
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BCL2L13 antibodies
     BCL2L13 proteins
     BCL2L13 lysates
     Antibodies for BCL2L13
     See all of Abcam's Antibodies, Kits and Proteins for BCL2L13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     BCL2L13 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for BCL2L13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L13
     SwitchGear 3'UTR luciferase reporter plasmids for BCL2L13
     SwitchGear Promoter luciferase reporter plasmids for BCL2L13
     ThermoFisher Antibodies for BCL2L13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2L13
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCL2L13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4