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Aliases for BCL2L12 Gene

Aliases for BCL2L12 Gene

  • BCL2-Like 12 (Proline Rich) 2 3
  • Bcl-2-Related Proline-Rich Protein 4
  • Bcl2-L-12 4
  • BPR 4

External Ids for BCL2L12 Gene

Summaries for BCL2L12 Gene

Entrez Gene Summary for BCL2L12 Gene

  • This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for BCL2L12 Gene

BCL2L12 (BCL2-Like 12 (Proline Rich)) is a Protein Coding gene.

Gene Wiki entry for BCL2L12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L12 Gene

Genomics for BCL2L12 Gene

Genomic Location for BCL2L12 Gene

Start:
49,665,142 bp from pter
End:
49,673,916 bp from pter
Size:
8,775 bases
Orientation:
Plus strand

Genomic View for BCL2L12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL2L12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L12 Gene

Regulatory Elements for BCL2L12 Gene

Proteins for BCL2L12 Gene

  • Protein details for BCL2L12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB09-B2L12_HUMAN
    Recommended name:
    Bcl-2-like protein 12
    Protein Accession:
    Q9HB09
    Secondary Accessions:
    • Q3SY11
    • Q3SY13
    • Q96I96
    • Q9HB08

    Protein attributes for BCL2L12 Gene

    Size:
    334 amino acids
    Molecular mass:
    36821 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2L12 Gene

Proteomics data for BCL2L12 Gene at MOPED

Post-translational modifications for BCL2L12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCL2L12 Gene

Domains for BCL2L12 Gene

Protein Domains for BCL2L12 Gene

UniProtKB/Swiss-Prot:

B2L12_HUMAN
Family:
  • Belongs to the Bcl-2 family.:
    • Q9HB09
genes like me logo Genes that share domains with BCL2L12: view

No data available for Gene Families for BCL2L12 Gene

Function for BCL2L12 Gene

Gene Ontology (GO) - Molecular Function for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0005515 protein binding IPI 19376117
genes like me logo Genes that share ontologies with BCL2L12: view

Phenotypes for BCL2L12 Gene

genes like me logo Genes that share phenotypes with BCL2L12: view

Animal Models for BCL2L12 Gene

MGI Knock Outs for BCL2L12:

miRNA for BCL2L12 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL2L12 Gene

Localization for BCL2L12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2L12 Gene COMPARTMENTS Subcellular localization image for BCL2L12 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20837658
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BCL2L12: view

Pathways for BCL2L12 Gene

SuperPathways for BCL2L12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 22262180
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA --
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IDA 22262180
GO:2000773 negative regulation of cellular senescence IEA --
genes like me logo Genes that share ontologies with BCL2L12: view

No data available for Pathways by source for BCL2L12 Gene

Transcripts for BCL2L12 Gene

Unigene Clusters for BCL2L12 Gene

BCL2-like 12 (proline rich):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2:
SP3: -
SP4: - -
SP5: - -
SP6:

Relevant External Links for BCL2L12 Gene

GeneLoc Exon Structure for
BCL2L12
ECgene alternative splicing isoforms for
BCL2L12

Expression for BCL2L12 Gene

mRNA expression in normal human tissues for BCL2L12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL2L12 Gene

SOURCE GeneReport for Unigene cluster for BCL2L12 Gene Hs.289052

mRNA Expression by UniProt/SwissProt for BCL2L12 Gene

Q9HB09-B2L12_HUMAN
Tissue specificity: Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle
genes like me logo Genes that share expressions with BCL2L12: view

Orthologs for BCL2L12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2L12 36
  • 98.9 (n)
  • 98.2 (a)
BCL2L12 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL2L12 36
  • 87.2 (n)
  • 90 (a)
BCL2L12 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL2L12 36
  • 88.15 (n)
  • 89.06 (a)
BCL2L12 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl2l12 36
  • 80.53 (n)
  • 84.8 (a)
Bcl2l12 16
Bcl2l12 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl2l12 36
  • 82.67 (n)
  • 85.6 (a)
lizard
(Anolis carolinensis)
Reptilia BCL2L12 37
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BCL2L12 37
  • 24 (a)
OneToOne
Species with no ortholog for BCL2L12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL2L12 Gene

ENSEMBL:
Gene Tree for BCL2L12 (if available)
TreeFam:
Gene Tree for BCL2L12 (if available)

Paralogs for BCL2L12 Gene

Pseudogenes.org Pseudogenes for BCL2L12 Gene

genes like me logo Genes that share paralogs with BCL2L12: view

No data available for Paralogs for BCL2L12 Gene

Variants for BCL2L12 Gene

Sequence variations from dbSNP and Humsavar for BCL2L12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs881785 -- 49,670,034(-) GGATA(C/G)TGGCC intron-variant
rs1045567 -- 49,673,529(+) CCTCA(A/C/T)CCCTG intron-variant
rs2379092 -- 49,669,379(+) aaaaa(A/T)aaaaa intron-variant
rs2379093 -- 49,669,381(+) aaaaa(A/C)aaaaa intron-variant
rs2569635 -- 49,671,463(-) aattt(G/T)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L12 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195

Relevant External Links for BCL2L12 Gene

HapMap Linkage Disequilibrium report
BCL2L12

Disorders for BCL2L12 Gene

(2) Novoseek inferred disease relationships for BCL2L12 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 24.9 5
cancer 0 1

Relevant External Links for BCL2L12

Genetic Association Database (GAD)
BCL2L12
Human Genome Epidemiology (HuGE) Navigator
BCL2L12
genes like me logo Genes that share disorders with BCL2L12: view

No data available for UniProtKB/Swiss-Prot for BCL2L12 Gene

Publications for BCL2L12 Gene

  1. Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. (PMID: 11401436) Scorilas A. … Diamandis E.P. (Genomics 2001) 3 4 23
  2. Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors. (PMID: 12783122) Talieri M. … Scorilas A. (Thromb. Haemost. 2003) 3 23
  3. Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer. (PMID: 15493871) Mathioudaki K. … Talieri M. (Biol. Chem. 2004) 3 23
  4. Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS. (PMID: 16895478) Thomadaki H. … Scorilas A. (Biol. Chem. 2006) 3 23
  5. What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. (PMID: 18769159) Stegh A.H. … DePinho R.A. (Cell Cycle 2008) 3 23

Products for BCL2L12 Gene

Sources for BCL2L12 Gene

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