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Aliases for BCL2L12 Gene

Aliases for BCL2L12 Gene

  • BCL2 Like 12 2 3 5
  • Bcl-2-Related Proline-Rich Protein 4
  • BCL2-Like 12 (Proline Rich) 2
  • Bcl2-L-12 4
  • BPR 4

External Ids for BCL2L12 Gene

Previous GeneCards Identifiers for BCL2L12 Gene

  • GC19P050826
  • GC19P050536
  • GC19P054844
  • GC19P054860
  • GC19P050168
  • GC19P046545

Summaries for BCL2L12 Gene

Entrez Gene Summary for BCL2L12 Gene

  • This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for BCL2L12 Gene

BCL2L12 (BCL2 Like 12) is a Protein Coding gene. GO annotations related to this gene include p53 binding.

Gene Wiki entry for BCL2L12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L12 Gene

Genomics for BCL2L12 Gene

Regulatory Elements for BCL2L12 Gene

Enhancers for BCL2L12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BCL2L12 on UCSC Golden Path with GeneCards custom track

Promoters for BCL2L12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BCL2L12 Gene

49,665,142 bp from pter
49,673,916 bp from pter
8,775 bases
Plus strand

Genomic View for BCL2L12 Gene

Genes around BCL2L12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L12 Gene

Proteins for BCL2L12 Gene

  • Protein details for BCL2L12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-like protein 12
    Protein Accession:
    Secondary Accessions:
    • Q3SY11
    • Q3SY13
    • Q96I96
    • Q9HB08

    Protein attributes for BCL2L12 Gene

    334 amino acids
    Molecular mass:
    36821 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL2L12 Gene


neXtProt entry for BCL2L12 Gene

Post-translational modifications for BCL2L12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCL2L12 Gene

Domains & Families for BCL2L12 Gene

Gene Families for BCL2L12 Gene

Protein Domains for BCL2L12 Gene

Suggested Antigen Peptide Sequences for BCL2L12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Bcl-2 family.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L12: view

Function for BCL2L12 Gene

Gene Ontology (GO) - Molecular Function for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
genes like me logo Genes that share ontologies with BCL2L12: view
genes like me logo Genes that share phenotypes with BCL2L12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL2L12 Gene

Localization for BCL2L12 Gene

Subcellular locations from

Jensen Localization Image for BCL2L12 Gene COMPARTMENTS Subcellular localization image for BCL2L12 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20837658
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with BCL2L12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL2L12 Gene

Pathways & Interactions for BCL2L12 Gene

SuperPathways for BCL2L12 Gene

No Data Available

SIGNOR curated interactions for BCL2L12 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BCL2L12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 22262180
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA --
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IDA 22262180
GO:2000773 negative regulation of cellular senescence IEA --
genes like me logo Genes that share ontologies with BCL2L12: view

No data available for Pathways by source for BCL2L12 Gene

Drugs & Compounds for BCL2L12 Gene

No Compound Related Data Available

Transcripts for BCL2L12 Gene

Unigene Clusters for BCL2L12 Gene

BCL2-like 12 (proline rich):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP3: -
SP4: - -
SP5: - -

Relevant External Links for BCL2L12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL2L12 Gene

mRNA expression in normal human tissues for BCL2L12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCL2L12 Gene

This gene is overexpressed in Bone (49.8) and Breast (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2L12 Gene

Protein tissue co-expression partners for BCL2L12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCL2L12 Gene:


SOURCE GeneReport for Unigene cluster for BCL2L12 Gene:


mRNA Expression by UniProt/SwissProt for BCL2L12 Gene:

Tissue specificity: Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with BCL2L12: view

Primer Products

No data available for mRNA differential expression in normal tissues for BCL2L12 Gene

Orthologs for BCL2L12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BCL2L12 34
  • 87.2 (n)
  • 90 (a)
BCL2L12 35
  • 90 (a)
(Canis familiaris)
Mammalia BCL2L12 34
  • 88.15 (n)
  • 89.06 (a)
BCL2L12 35
  • 88 (a)
(Mus musculus)
Mammalia Bcl2l12 34
  • 80.53 (n)
  • 84.8 (a)
Bcl2l12 16
Bcl2l12 35
  • 83 (a)
(Pan troglodytes)
Mammalia BCL2L12 34
  • 98.9 (n)
  • 98.2 (a)
BCL2L12 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Bcl2l12 34
  • 82.67 (n)
  • 85.6 (a)
(Anolis carolinensis)
Reptilia BCL2L12 35
  • 31 (a)
(Danio rerio)
Actinopterygii BCL2L12 35
  • 24 (a)
Species where no ortholog for BCL2L12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL2L12 Gene

Gene Tree for BCL2L12 (if available)
Gene Tree for BCL2L12 (if available)

Paralogs for BCL2L12 Gene Pseudogenes for BCL2L12 Gene

genes like me logo Genes that share paralogs with BCL2L12: view

No data available for Paralogs for BCL2L12 Gene

Variants for BCL2L12 Gene

Sequence variations from dbSNP and Humsavar for BCL2L12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_048419 -
rs3210720 -- 49,670,238(+) CCTGC(C/G)CAGCA intron-variant, nc-transcript-variant, reference, missense
rs3210721 -- 49,670,254(+) GTCCG(A/C)CTGTC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs3745469 -- 49,673,914(-) GAATA(C/T)TTTGT nc-transcript-variant, utr-variant-3-prime
rs34075534 -- 49,669,680(+) CACAA(C/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L12 Gene

Variant ID Type Subtype PubMed ID
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv817854 CNV gain 17921354
nsv828578 CNV loss 20364138
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for BCL2L12 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L12 Gene

Disorders for BCL2L12 Gene

Relevant External Links for BCL2L12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BCL2L12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCL2L12 Gene

Publications for BCL2L12 Gene

  1. Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family. (PMID: 11401436) Scorilas A. … Diamandis E.P. (Genomics 2001) 3 4 22 65
  2. Molecular analysis and prognostic impact of the novel apoptotic gene BCL2L12 in gastric cancer. (PMID: 19903463) Florou D. … Scorilas A. (Biochem. Biophys. Res. Commun. 2010) 3 22 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly J.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 65
  5. What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. (PMID: 18769159) Stegh A.H. … DePinho R.A. (Cell Cycle 2008) 3 22 65

Products for BCL2L12 Gene

Sources for BCL2L12 Gene

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