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BCL2L11 Gene

protein-coding   GIFtS: 68
GCID: GC02P111876

BCL2-Like 11 (Apoptosis Facilitator)

  See BCL2L11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BCL2-Like 11 (Apoptosis Facilitator)1 2     Bcl-2 Interacting Protein Bim2
BIM2 3 5     Bcl-2-Like Protein 112
BAM2     Bcl-2-Related Ovarian Death Agonist2
BOD2     Bcl2-L-113
Bcl-2 Interacting Mediator Of Cell Death2     Bcl2-Interacting Mediator Of Cell Death3

External Ids:    HGNC: 9941   Entrez Gene: 100182   Ensembl: ENSG000001530947   OMIM: 6038275   UniProtKB: O435213   

Export aliases for BCL2L11 gene to outside databases

Previous GC identifers: GC02P109111 GC02P109802 GC02P111785 GC02P111976 GC02P111597 GC02P104757


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCL2L11 Gene:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or
homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular
activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to
interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of
this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1,
which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse
counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative
selection. Several alternatively spliced transcript variants of this gene have been identified. (provided by
RefSeq, Jun 2013)

GeneCards Summary for BCL2L11 Gene:
BCL2L11 (BCL2-like 11 (apoptosis facilitator)) is a protein-coding gene. Diseases associated with BCL2L11 include hematologic cancer, and mn1. GO annotations related to this gene include microtubule binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521
Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1,
isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL
and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a
caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis

summary for BCL2L11 Gene:
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein
family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as
Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2
proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma
and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members
contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial
and other intracellular membranes.

Gene Wiki entry for BCL2L11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCL2L11 gene promoter:
         AML1a   Pax-5   C/EBPalpha   CREB   CHOP-10   deltaCREB   Chx10   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): BCL2L11 promoter sequence
   Search Chromatin IP Primers for BCL2L11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL2L11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

BCL2L11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P111876:  view genomic region     (about GC identifiers)

Start:
111,876,955 bp from pter      End:
111,926,024 bp from pter
Size:
49,070 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521 (See protein sequence)
Recommended Name: Bcl-2-like protein 11  
Size: 198 amino acids; 22171 Da
Subunit: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform
Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCLW. Isoform BimS and isoform Bim-alpha3 interact with BAX; this interaction
induces the conformationally active form of BAX. Does not heterodimerize with proapoptotic proteins such as BAD,
BOK or BAK. Interacts with DYNLL1 and YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is
associated with ubiquitination and degradation. Interacts with MCL1; may sequester BCL2L11 to prevent its
pro-apoptotic activity
Selected PDB 3D structures from and Proteopedia for BCL2L11 (see all 15):
1F95 (3D)        2K7W (3D)        2NL9 (3D)        2V6Q (3D)        2VM6 (3D)        2WH6 (3D)    
Secondary accessions: A8K2W2 O43522 Q0MSE7 Q0MSE8 Q0MSE9 Q53R28 Q6JTU6 Q6T851 Q6TE14 Q6TE15
Q6TE16 Q6V402 Q8WYL6 Q8WYL7 Q8WYL8 Q8WYL9 Q8WYM0 Q8WYM1
Alternative splicing: 20 isoforms:  O43521-1   O43521-2   O43521-3   O43521-4   O43521-5   O43521-6   O43521-7   O43521-8   
O43521-9   O43521-10   O43521-11   O43521-12   O43521-13   O43521-14   O43521-15   O43521-16   
O43521-17   O43521-18   O43521-19   O43521-20   

Explore the universe of human proteins at neXtProt for BCL2L11: NX_O43521

Explore proteomics data for BCL2L11 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-69 by MAPK1/MAPK3 induces interaction with TRIM2, followed by polyubiquitination1
  • Ubiquitinated by TRIM2 following phosphorylation by MAPK1/MAPK3, leading to degradation by the proteasome (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BCL2L11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (18 alternative transcripts): 
    NP_001191035.1  NP_001191036.1  NP_001191037.1  NP_001191038.1  NP_001191039.1  NP_001191040.1  NP_001191041.1  NP_001191042.1  
    NP_006529.1  NP_619527.1  NP_619528.1  NP_619529.1  NP_619530.1  NP_619531.1  NP_619532.1  NP_619533.1  
    NP_996885.1  NP_996886.1  

    ENSEMBL proteins: 
     ENSP00000411870   ENSP00000309226   ENSP00000376943   ENSP00000376941   ENSP00000401662  
     ENSP00000384641   ENSP00000393781   ENSP00000403727   ENSP00000412892   ENSP00000391292  
     ENSP00000354879   ENSP00000394640   ENSP00000411137   ENSP00000389225   ENSP00000350398  
     ENSP00000376942   ENSP00000338374  
    Reactome Protein details: O43521

    BCL2L11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BCL2L11 (BIM Long)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BCL2L11
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BCL2L11
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    Novus Biologicals BCL2L11 Proteins
    Novus Biologicals BCL2L11 Lysate
    Sino Biological Recombinant Protein for BCL2L11
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BCL2L11
    Cloud-Clone Corp. Proteins for BCL2L11

     
    Search eBioscience for Proteins for BCL2L11 

     
    antibodies-online proteins for BCL2L11 (11 products) 

     
    antibodies-online peptides for BCL2L11

    BCL2L11 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2L11
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    ThermoFisher Antibody for BCL2L11
    LSBio Antibodies in human, mouse, rat for BCL2L11
    antibodies-online antibodies for BCL2L11 (238 products) 

    BCL2L11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCL2L11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCL2L11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BCL2L11
    Cloud-Clone Corp. CLIAs for BCL2L11
    Search eBioscience for ELISAs for BCL2L11 
    antibodies-online kits for BCL2L11 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015040 Bcl-x_interacting_BH3_dom
     IPR017288 Bcl-2-like_11
     IPR014771 Apoptosis_Bim_N

    Graphical View of Domain Structure for InterPro Entry O43521

    ProtoNet protein and cluster: O43521

    1 Blocks protein domain: IPB009616 Bim

    UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521
    Domain: The BH3 motif is required for Bcl-2 binding and cytotoxicity
    Similarity: Belongs to the Bcl-2 family


    Find genes that share domains with BCL2L11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B2L11_HUMAN, O43521
    Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1,
    isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL
    and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a
    caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis
    Induction: By ER stress in a DDIT3/CHOP-dependent manner

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14596824
    GO:0008017microtubule binding IEA--
    GO:0046982protein heterodimerization activity ----
         
    Find genes that share ontologies with BCL2L11           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BCL2L11:
     G0/1 arrest  Increased G1 DNA content 

         Selected MGI mutant phenotypes (inferred from 15 alleles(MGI details for Bcl2l11) (see all 18):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  normal  pigmentation 

    Find genes that share phenotypes with BCL2L11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BCL2L11: Bcl2l11tm1Ast Bcl2l11tm1Sjk Bcl2l11tm1.1Ast

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL2L11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCL2L11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL2L11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL2L11

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCL2L11:
    hsa-mir-17-5p (MIRT001206), hsa-mir-340-5p (MIRT019539), hsa-mir-181a-5p (MIRT005767), hsa-mir-19a-3p (MIRT004452), hsa-mir-10b-5p (MIRT006366), hsa-mir-494-3p (MIRT006981), hsa-mir-375 (MIRT019675), hsa-let-7a-5p (MIRT052551), hsa-mir-221-3p (MIRT000140), hsa-mir-195-5p (MIRT000785), hsa-mir-32-5p (MIRT003739), hsa-mir-25-3p (MIRT003413), hsa-mir-24-3p (MIRT030547), hsa-mir-19b-3p (MIRT004523)

    Block miRNA regulation of human, mouse, rat BCL2L11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL2L11 (see all 130):
    hsa-miR-376b hsa-miR-106a hsa-miR-1245 hsa-miR-938 hsa-miR-3653 hsa-miR-3921 hsa-miR-4275 hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat BCL2L11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCL2L11

    Clone
    Products:
         
    OriGene clones in human, mouse for BCL2L11 (see all 21)
    OriGene ORF clones in mouse, rat for BCL2L11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 18): BCL2L11 (NM_006538)
    Sino Biological Human cDNA Clone for BCL2L11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2L11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2L11
    Addgene plasmids for BCL2L11 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L11

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10816) for BCL2L11 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B2L11_HUMAN, O43521: Endomembrane system; Peripheral membrane protein (By similarity). Note=Associated with
    intracytoplasmic membranes (By similarity)
    B2L11_HUMAN, O43521: Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of
    cell adherence
    B2L11_HUMAN, O43521: Isoform BimL: Mitochondrion
    B2L11_HUMAN, O43521: Isoform BimS: Mitochondrion
    B2L11_HUMAN, O43521: Isoform Bim-alpha1: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus3
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    plasma membrane1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005829cytosol TAS--
    GO:0005874colocalizes with microtubule IDA--

    Find genes that share ontologies with BCL2L11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCL2L11 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members0.00
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    2p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    3Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BIM and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Cellular Apoptosis Pathway0.85
    5Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38


    Find genes that share SuperPaths with BCL2L11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for BCL2L11
        Akt Signaling Pathway

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BCL2L11
        Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    14-3-3 and Regulation of BAD Activity
    Cellular Apoptosis Pathway

    1 Cell Signaling Technology (CST) Pathway for BCL2L11
        Apoptosis and Autophagy

    3 GeneGo (Thomson Reuters) Pathways for BCL2L11
        Apoptosis and survival FAS signaling cascades
    Signal transduction AKT signaling
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    Selected BioSystems Pathways for BCL2L11 (see all 10)
        Apoptosis
    Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)
    ErbB signaling pathway
    BDNF signaling pathway


    3 Reactome Pathways for BCL2L11
        Activation of BIM and translocation to mitochondria
    NRAGE signals death through JNK
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members


    4 Kegg Pathways  (Kegg details for BCL2L11):
        FoxO signaling pathway
    PI3K-Akt signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL2L11: 
              Cancer PathwayFinder in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL2L11

    Selected Interacting proteins for BCL2L11 (O435211, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078121, 2, 3EBI-526406,EBI-516580 MINT-4980301 MINT-7034079 MINT-4980279 MINT-7034069 MINT-7034114 MINT-4980319 I2D: score=2 
    MCL1Q078201, 2, 3EBI-526406,EBI-1003422 MINT-68751 MINT-4980348 MINT-4980279 MINT-4980319 MINT-7543162 I2D: score=12 
    BCL2P104151, 2, 3EBI-526406,EBI-77694 MINT-6629252 MINT-4980319 I2D: score=12 
    BADQ929341, 2, 3EBI-526406,EBI-700771 MINT-7034091 MINT-7034079 I2D: score=1 
    BCL2L1Q078171, 2, 3EBI-526406,EBI-78035 MINT-4980301 MINT-4980319 I2D: score=10 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001776leukocyte homeostasis ----
    GO:0001782B cell homeostasis IEA--
    GO:0001783B cell apoptotic process IEA--
    GO:0001822kidney development IEA--

    Find genes that share ontologies with BCL2L11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for BCL2L11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AT 101Downregulates Bcl-2 and Mcl-1; pro-apoptotic[90141-22-3]
    HA14-1Bcl-2 inhibitor. Induces apoptosis[65673-63-4]
    MIM1Mcl-1 inhibitor; proapoptotic--
    Bax channel blockerInhibits Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide V5Inhibitor of Bax-mediated apoptosis[579492-81-2]

    Selected Novoseek inferred chemical compound relationships for BCL2L11 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 88.3 54 18794091 (4), 16888645 (4), 17525724 (4), 17618288 (3) (see all 23)
    bortezomib 70.6 12 15767553 (5), 16528474 (1), 17545623 (1), 15766661 (1)
    suberoylanilide hydroxamic acid 66.6 8 18505786 (2), 17470784 (1), 19330811 (1), 17351739 (1)
    sp 600125 59.1 1 17698840 (1)
    mg 132 55 5 16230407 (2), 18064628 (1), 16431916 (1)
    ly294002 50.6 7 18251703 (1), 12618753 (1), 18266951 (1), 15855272 (1) (see all 5)
    gossypol 48.6 11 16258364 (2), 17156797 (1)
    imatinib 48.5 34 15688014 (7), 16230407 (4), 15226421 (3), 20231287 (2) (see all 10)
    depsipeptide 45.6 8 19308286 (4), 15069698 (1)
    etoposide 35.8 2 16778834 (2)



    Find genes that share compounds with BCL2L11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BCL2L11 gene (18 alternative transcripts): 
    NM_001204106.1  NM_001204107.1  NM_001204108.1  NM_001204109.1  NM_001204110.1  NM_001204111.1  NM_001204112.1  NM_001204113.1  
    NM_006538.4  NM_138621.4  NM_138622.3  NM_138623.3  NM_138624.3  NM_138625.3  NM_138626.3  NM_138627.3  
    NM_207002.3  NM_207003.2  

    Unigene Cluster for BCL2L11:

    BCL2-like 11 (apoptosis facilitator)
    Hs.469658  [show with all ESTs]
    Unigene Representative Sequence: NM_001204108
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432179 ENST00000308659 ENST00000393256(uc002thb.2 uc002tgx.2 uc021vmp.1 uc010fkd.2 uc002tgz.2 uc002thd.2 uc002tha.2 uc010fke.2 uc021vmq.1 uc002thc.2 uc021vmr.1 uc002tgw.2 uc021vms.1 uc002tgu.1 uc002tgy.2 uc002tgv.1)
    ENST00000393252 ENST00000433098 ENST00000405953 ENST00000415458 ENST00000436733
    ENST00000437029 ENST00000452231 ENST00000361493 ENST00000431217 ENST00000439718
    ENST00000438054(uc021vmo.1) ENST00000357757 ENST00000393253 ENST00000337565(uc002tgt.1)

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    Additional mRNA sequence: 

    AF032457.1 AF032458.1 AF086141.1 AK027160.1 AK290377.1 AK291269.1 AY305714.1 AY352518.1 
    BC033694.1 DQ849201.1 

    7 DOTS entries:

    DT.100662647  DT.100755121  DT.75123969  DT.447772  DT.95270536  DT.121016827  DT.91827574 

    Selected AceView cDNA sequences (see all 185):

    AI590070 AA019073 AI151517 AW136146 AB071200 CA843589 AA861490 AB071198 
    AA016186 AA748859 AW119033 AY352518 W81277 NM_138624 BQ446484 AI261753 
    AA699672 AI261518 NM_207003 H85882 NM_138621 AY428962 BU178928 AA346887 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L11 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -     -                       -               
    SP2:              -     -                 -                     
    SP3:                                      -     -               
    SP4:              -     -                                       
    SP5:              -     -                 -     -               


    ECgene alternative splicing isoforms for BCL2L11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BCL2L11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTGGTTC
    BCL2L11 Expression
    About this image

    BCL2L11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL2L11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469658

    UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521
    Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously
    expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and
    colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2L11 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl2l111 , 5 BCL2-like 11 (apoptosis facilitator)1, 5 89.35(n)1
    89.18(a)1
      2 (62.23 cM)5
    121251  NM_207680.21  NP_997563.11 
     1281260385 
    lizard
    (Anolis carolinensis)
    Reptilia BCL2L116
    BCL2-like 11 (apoptosis facilitator)
    42(a)
    1 ↔ 1
    GL343437.1(718198-740996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bcl2l111 bcl2-like 11 (apoptosis facilitator) 60.49(n)
    56.61(a)
      613103  NM_001032340.1  NP_001027511.1 


    ENSEMBL Gene Tree for BCL2L11 (if available)
    TreeFam Gene Tree for BCL2L11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCL2L11 (see all 1082)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387800741,2
    C--104782648(+) GCTTT-/CTTTTT 17 -- int10--------
    rs38382201,2
    C--104792882(-) CACACAT/-GTTTG 16 -- int11Minor allele frequency- -:0.00CSA 2
    rs728363451,2
    C,F--111389899(+) TTTAGT/CGCCCC 18 -- us2k11Minor allele frequency- C:0.09NA 120
    rs1849335841,2
    --111389915(+) GCAGCA/GCTTAG 18 -- us2k10--------
    rs1463572541,2
    C--111389969(+) GTCGCA/GAGAGC 18 -- us2k10--------
    rs728363461,2
    C,F--111389973(+) CGAGAG/CCGAGC 18 -- us2k11Minor allele frequency- C:0.11NA 120
    rs75778241,2
    C,F,A--111390123(+) GCTTCG/AGGCTC 18 -- us2k17Minor allele frequency- A:0.43WA NA CSA EA 366
    rs1389824591,2
    --111390252(+) CGAGTC/TTACTT 18 -- us2k10--------
    rs75936381,2
    C,F,A--111390301(+) AAATAA/CCTGGG 18 -- us2k16Minor allele frequency- C:0.43WA NA CSA EA 364
    rs1430068731,2
    --111390432(+) TTACAA/GAAGCG 18 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCL2L11 (111876955 - 111926024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for BCL2L11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667742CNV Deletion23128226
    esv2720516CNV Deletion23290073
    nsv874842CNV Loss21882294
    nsv829619CNV Loss20364138
    nsv428402CNV Loss18775914
    nsv834331CNV Loss17160897
    nsv874838CNV Loss21882294
    nsv521956CNV Loss19592680
    nsv829618CNV Gain20364138
    dgv1236e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): BCL2L11
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing BCL2L11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603827    OMIM disorders: --

    5 diseases for BCL2L11:    
    About MalaCards
    hematologic cancer    mn1    burkitt's lymphoma    glucocorticoid resistance
    chronic myeloid leukemia

    2 diseases from the University of Copenhagen DISEASES database for BCL2L11:
    Leukemia     Lymphoma

    Find genes that share disorders with BCL2L11           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BCL2L11 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 42.5 16 15459900 (4), 19914305 (2), 17158029 (2), 17681275 (1) (see all 9)
    tumors 41 38 15079075 (3), 19881544 (2), 18794091 (2), 15766661 (2) (see all 22)
    cancer 39.8 7 19308286 (1), 20112357 (1), 19904742 (1), 16443928 (1) (see all 6)
    melanoma 32.6 38 17637819 (6), 18715233 (5), 17051334 (2), 17652623 (2) (see all 8)
    leukemia 23.8 9 19773546 (2), 17233818 (2), 19850739 (1), 14996839 (1) (see all 7)
    burkitt lymphoma 22.8 4 16116183 (1), 19332026 (1), 18193085 (1)
    lymphoma 20.6 7 16094360 (2), 17470784 (1), 15505424 (1), 17525724 (1) (see all 5)
    breast cancer 19.3 9 14527951 (3), 17914587 (1), 16443928 (1), 19242112 (1) (see all 7)
    prostate cancer 17.2 6 12019181 (2), 15767553 (1), 12629510 (1)
    pancreatic cancer 15.5 1 16258364 (1)

    Genetic Association Database (GAD): BCL2L11
    Human Genome Epidemiology (HuGE) Navigator: BCL2L11 (10 documents)

    Export disorders for BCL2L11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCL2L11 gene, integrated from 10 sources (see all 521):
    (articles sorted by number of sources associating them with BCL2L11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bim: a novel member of the Bcl-2 family that promotes apoptosis. (PubMed id 9430630)1, 2, 3 O'Connor L.... Huang D.C.S. (EMBO J. 1998)
    2. Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis. (PubMed id 15147734)1, 2, 9 Chen J.Z.... Mao Y.M. (Int. J. Biochem. Cell Biol. 2004)
    3. Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. (PubMed id 12019181)1, 2, 9 Liu J.-W.... Tang D.G. (Cancer Res. 2002)
    4. Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. (PubMed id 11734221)1, 2, 9 Mami U.... Yamada M. (FEBS Lett. 2001)
    5. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. (PubMed id 21151127)1, 4 Melum E....Karlsen T.H. (Nat. Genet. 2011)
    6. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PubMed id 21533175)1, 4 Zhai G....Wallaschofski H. (PLoS Genet. 2011)
    7. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. (PubMed id 21478148)1, 2 Thompson S.... Meller R. (J. Biol. Chem. 2011)
    8. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    9. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    10. Genetic susceptibility variants for chronic lymphocytic leukemia. (PubMed id 20332261)1, 4 Slager S.L....Cerhan J.R. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10018 HGNC: 994 AceView: BCL2L11 Ensembl:ENSG00000153094 euGenes: HUgn10018
    ECgene: BCL2L11 Kegg: 10018 H-InvDB: BCL2L11

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BCL2L11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL2L11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCL2L11 gene:
    Search GeneIP for patents involving BCL2L11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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