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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL2L10 Gene

protein-coding GIFtS: 54
GCID: GC15M052401

BCL2-like 10 (apoptosis facilitator)

Explore 18 diseases affiliated with
BCL2L10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BCL2-Like 10 (Apoptosis Facilitator)¹ ²		Apoptosis Regulator Bcl-B² ³
BCL-B¹ ²		Bcl-2-Like Protein 10²
Boo¹ ²		Bcl2-L-10³
Diva¹ ²		BCLB³
Anti-Apoptotic Protein NrH² ³		Bcl2-L-10³

External Ids:	HGNC: 993¹	Entrez Gene: 10017²	Ensembl: ENSG00000137875⁷	OMIM: 606910⁵	UniProtKB: Q9HD36³

Export aliases for BCL2L10 gene to outside databases

Previous GC identifers: GC15M047960 GC15M045448 GC15M049980 GC15M050117 GC15M050189 GC15M029232

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2L10:

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers

and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein

encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of

BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress

cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating

caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein

complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic

pathway. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: B2L10_HUMAN, Q9HD36

Function: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK

Gene Wiki entry for BCL2L10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL2L10 gene promoter:
E2F-3a E2F-4 E2F-5 GATA-3 Lmo2 E2F-2 C/EBPalpha E2F E2F-1 ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BCL2L10 promoter sequence

Search SABiosciences Chromatin IP Primers for BCL2L10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2L10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21

BCL2L10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L10 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M052401: view genomic region (about GC identifiers)

Start:	52,401,460 bp from pter	End:	52,404,972 bp from pter
Size:	3,513 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B2L10_HUMAN, Q9HD36 (See protein sequence)

Recommended Name: Bcl-2-like protein 10

Size: 194 amino acids; 21973 Da

Subunit: Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1

Subcellular location: Mitochondrion. Nucleus membrane

Sequence caution: Sequence=AAG00503.1; Type=Erroneous initiation; Sequence=AAH93826.1; Type=Erroneous initiation;

Sequence=AAH93828.1; Type=Erroneous initiation; Sequence=AAI04443.1; Type=Erroneous initiation; Sequence=AAI04444.1;

Type=Erroneous initiation; Sequence=AAK48715.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for BCL2L10:

4B4S (3D)

Secondary accessions: Q3SX80 Q52LQ9 Q8TCS9

Explore the universe of human proteins at neXtProt for BCL2L10: NX_Q9HD36

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HD36

BCL2L10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065129.1

ENSEMBL proteins:

ENSP00000260442 ENSP00000453562

Human Recombinant Protein Products:

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	Uscn Proteins for BCL2L10

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005739	mitochondrion	IDA	11278245
GO:0005829	cytosol	IDA	11278245
GO:0016020	membrane	TAS	9878060
GO:0016021	integral to membrane	IEA	--

BCL2L10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCL2L10 for domains About GeneDecksing

5 InterPro domains/families:

IPR002475 Bcl2-like

IPR026298 Blc2_fam

IPR026312 BCL2L10

IPR020717 Bcl2_BH1_motif_CS

IPR020726 Bcl2_BH2_motif_CS

Graphical View of Domain Structure for InterPro Entry Q9HD36

ProtoNet protein and cluster: Q9HD36

1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: B2L10_HUMAN, Q9HD36

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: B2L10_HUMAN, Q9HD36

Function: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2L10
		1 QIAGEN miScript miRNA Assays for microRNA that regulate BCL2L10:
		hsa-miR-4277
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In Situ Assay
Products:

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11278245

BCL2L10 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Bcl2l10^tm1Pmc for BCL2L10
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Bcl2l10):

normal

BCL2L10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

0.24

Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins

0.24

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Busulfan Pathway, Pharmacodynamics

Busulfan Pathway, Pharmacodynamics

1.00

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for BCL2L10

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

1 Cell Signaling Technology (CST) Pathway for BCL2L10

Apoptosis and Autophagy

1 GeneGo (Thomson Reuters) Pathway for BCL2L10

Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

1 BioSystems Pathway for BCL2L10

Apoptosis Modulation and Signaling

1 PharmGKB Pathway for BCL2L10

Busulfan Pathway, Pharmacodynamics

BCL2L10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BCL2L10

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/13 Interacting proteins for BCL2L10 (Q9HD36^{2, 3} ENSP00000260442⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MT-RNR2	Q8IVG9²^,³	MINT-19419 I2D: score=1
BAX	Q07812³, ENSP00000293288⁴	I2D: score=2 STRING: ENSP00000293288
BCL2	P10415³, ENSP00000329623⁴	I2D: score=2 STRING: ENSP00000329623
APAF1	O14727³, ENSP00000353059⁴	I2D: score=1 STRING: ENSP00000353059
BAD	Q92934³, ENSP00000309103⁴	I2D: score=1 STRING: ENSP00000309103

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	--	--
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	9829980
GO:0007283	spermatogenesis	TAS	9878060
GO:0007292	female gamete generation	TAS	9878060
GO:0042981	regulation of apoptotic process	--	--

BCL2L10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BCL2L10
Search CenterWatch for drugs/clinical trials and news about BCL2L10 / B2L10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BCL2L10 gene:

NM_020396.2

Unigene Cluster for BCL2L10:

BCL2-like 10 (apoptosis facilitator)

Hs.283672 [show with all ESTs]

Unigene Representative Sequence: NM_020396

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000260442(uc002abq.3) ENST00000561198

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2L10
		1 QIAGEN miScript miRNA Assays for microRNA that regulate BCL2L10:
		hsa-miR-4277
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Additional cDNA sequence:

AF285092.1 AF326964.1 BC093826.1 BC093828.1 BC104442.1 BC104443.1 BC143227.1

1 DOTS entry:

DT.108849

4 AceView cDNA sequences:

NM_020396 AF285092 AF326964 AA005293

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL2L10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGTTAACA

About this image

BCL2L10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

See BCL2L10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL2L10

SOURCE GeneReport for Unigene cluster: Hs.283672

UniProtKB/Swiss-Prot: B2L10_HUMAN, Q9HD36

Tissue specificity: Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2L10:

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BCL2L10 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bcl2l10^{1 , 5}	Bcl2-like 10^{1, 5}	67.03(n)¹ 50.81(a)¹		9 (42.30 cM)⁵ 12049¹ NM_013479.2¹ NP_038507.1¹ 75347758⁵
zebrafish (Danio rerio)	Actinopterygii	bcl2l10⁶	BCL2-like 10 (apoptosis facilitator)	25(a)	1 ↔ 1	18(37544009-37556294)

ENSEMBL Gene Tree for BCL2L10 (if available)
TreeFam Gene Tree for BCL2L10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191743055^1,2		--	52401407(+)	`CATCAA/TTTCTA`	1	--	ds500¹		0	--	--	--	--
rs184712827^1,2		--	52401414(+)	`TCTACC/TTACTC`	1	--	ds500¹		0	--	--	--	--
rs143525072^1,2		--	52401432(+)	`TGAACA/GCTTAT`	1	--	ds500¹		0	--	--	--	--
rs138692638^1,2		--	52401457(+)	`CTAAG-/ATTTTT`	1	--	ds500¹		0	--	--	--	--
rs148037270^1,2		--	52401490(+)	`AAAACC/TTTGCA`	1	--	ds500¹		0	--	--	--	--
rs76299580^1,2		--	52401539(+)	`AAACCC/TAGAAG`	1	--	ds500¹		0	--	--	--	--
rs7172382^1,2	C,F,H,	--	52401638(+)	`TTCTAC/ATTTGG`	1	--	ds500¹		5		NS EA WA	514
rs190055812^1,2		--	52401719(+)	`AGGTTC/TGCACT`	1	--	ds500¹		0	--	--	--	--
rs2231297^1,2	C,F,A,H,	--	52401933(-)	`TTTTAC/TCTGAA`	1	--	ut3¹		25		EA NA NS CSA WA	2564
rs2227308^1,2	C,F,H,	--	52401951(-)	`TTCCCC/TCACCC`	1	--	ut3¹ ese³		18		EA NS NA	3704

HapMap Linkage Disequilibrium report for BCL2L10 (52401460 - 52404972 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BCL2L10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2L10

DNA2.0 Custom Variant and Variant Library Synthesis for BCL2L10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BCL2L10 for disorders           About GeneDecksing

OMIM gene information: 606910    OMIM disorders: --

18 diseases for BCL2L10:    About MalaCards

epididymo-orchitis non-hodgkin lymphoma orchitis neurogenic bladder

urethral obstruction urethritis hodgkin's lymphoma acute myeloid leukemia

myeloid leukemia prostatic hypertrophy myelodysplastic syndrome gingivitis

periodontitis gastric cancer leukemia cervicitis

prostatitis carcinoma

Human Genome Epidemiology (HuGE) Navigator: BCL2L10 (7 documents)

Export disorders for BCL2L10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BCL2L10 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with BCL2L10)

Utopia: connect your pdf to the dynamic
world of online information

Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. (PubMed id 11689480)^{1, 2, 9} Zhang H.... De Geyter C. (2001)
Boo, a novel negative regulator of cell death, interacts with Apaf-1. (PubMed id 9878060)^{1, 3, 9} Song Q....Vincenz C. (1999)
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. (PubMed id 11278245)^{1, 2, 9} Ke N.... Reed J.C. (2001)
NrH, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis. (PubMed id 11593390)^{1, 2} Aouacheria A....Gillet G. (2001)
Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. (PubMed id 9829980)^{1, 3} Inohara N....Nunez G. (1998)
HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. (PubMed id 19255499)^{1, 9} Kim J.H....Bae J. (2009)
The anti-apoptotic Bcl-B protein inhibits BECN1-depend ent autophagic cell death. (PubMed id 22498477)¹ Robert G....Luciano F. (2012)
BCL2L10 is a predictive factor for resistance to azaci tidine in MDS and AML patients. (PubMed id 22577154)¹ Cluzeau T....Auberger P. (2012)
Ubiquitination, localization, and stability of an anti -apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. (PubMed id 22233804)¹ Beverly L.J....Varmus H. (2012)
BCL2L10 protein regulates apoptosis/proliferation thr ough differential pathways in gastric cancer cells. (PubMed id 21171085)¹ Xu J.D....Li Q.Q. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10017	HGNC: 993	AceView: BCL2L10	Ensembl:ENSG00000137875	euGenes: HUgn10017
ECgene: BCL2L10	H-InvDB: BCL2L10

(According to HUGE)
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BCL2L10 Gene

BCL2-like 10 (apoptosis facilitator)

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BCL2L10 Gene

BCL2-like 10 (apoptosis facilitator)

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