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Aliases for BCL2L10 Gene

Aliases for BCL2L10 Gene

  • BCL2 Like 10 2 3 5
  • BCL2-Like 10 (Apoptosis Facilitator) 2 3
  • Anti-Apoptotic Protein NrH 3 4
  • Apoptosis Regulator Bcl-B 3 4
  • Bcl2-L-10 3 4
  • Death Inducer Binding To VBcl-2 And Apaf-1 3
  • Bcl-2-Like Protein 10 3
  • BCL-B 3
  • Diva 3
  • BCLB 4
  • Boo 3

External Ids for BCL2L10 Gene

Previous GeneCards Identifiers for BCL2L10 Gene

  • GC15M047960
  • GC15M045448
  • GC15M049980
  • GC15M050117
  • GC15M050189
  • GC15M052401
  • GC15M029232
  • GC15M052415
  • GC15M052685
  • GC15M054207
  • GC15M054934
  • GC15M055375
  • GC15M055822

Summaries for BCL2L10 Gene

Entrez Gene Summary for BCL2L10 Gene

  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL2L10 Gene

BCL2L10 (BCL2 Like 10) is a Protein Coding gene. Diseases associated with BCL2L10 include Prostatic Cyst and Urethral Stricture. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for BCL2L10 Gene

  • Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.

Gene Wiki entry for BCL2L10 Gene

Additional gene information for BCL2L10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L10 Gene

Genomics for BCL2L10 Gene

Regulatory Elements for BCL2L10 Gene

Enhancers for BCL2L10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H052076 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +34.5 34546 4 FOXA2 PKNOX1 ARID4B DMAP1 YY1 TCF12 ZNF143 FOS RUNX3 SP5 MAPK6 BCL2L10 LYSMD2 GNB5 ENSG00000259178 DMXL2 ENSG00000259398
GH15H052018 1.4 ENCODE dbSUPER 12.5 +92.2 92175 5 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ENSG00000259935 ENSG00000259712 ENSG00000260618 FAM214A BCL2L10 LYSMD2 MAPK6 DMXL2 ENSG00000259438 ENSG00000259398
GH15H052133 1.2 Ensembl ENCODE 13.2 -21.7 -21739 2 HDGF PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ZNF143 ATF7 BCL2L10 GNB5 MAPK6 CERNA1 ENSG00000259709 GC15P052163
GH15H052071 1.1 ENCODE dbSUPER 12.7 +41.2 41214 1 ELF3 FOXA2 PKNOX1 MLX ARID4B SIN3A RAD21 RFX5 YY1 FOS BCL2L10 MAPK6 GNB5 CERNA1 ENSG00000259178 ENSG00000259398
GH15H052066 1.1 ENCODE dbSUPER 12.1 +44.4 44408 3 PKNOX1 FOXA2 FEZF1 RAD21 YY1 ZNF121 ZSCAN5C PAF1 CEBPB MXD4 BCL2L10 MAPK6 LEO1 GNB5 LYSMD2 ENSG00000259178 ENSG00000259398
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCL2L10 on UCSC Golden Path with GeneCards custom track

Promoters for BCL2L10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076676 342 201 CTCF ZNF687 TRIM22 MAX DPF2 MYC

Genomic Location for BCL2L10 Gene

Chromosome:
15
Start:
52,109,263 bp from pter
End:
52,113,042 bp from pter
Size:
3,780 bases
Orientation:
Minus strand

Genomic View for BCL2L10 Gene

Genes around BCL2L10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL2L10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL2L10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L10 Gene

Proteins for BCL2L10 Gene

  • Protein details for BCL2L10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD36-B2L10_HUMAN
    Recommended name:
    Bcl-2-like protein 10
    Protein Accession:
    Q9HD36
    Secondary Accessions:
    • Q3SX80
    • Q52LQ9
    • Q8TCS9

    Protein attributes for BCL2L10 Gene

    Size:
    194 amino acids
    Molecular mass:
    21973 Da
    Quaternary structure:
    • Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.
    SequenceCaution:
    • Sequence=AAG00503.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93826.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04443.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04444.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK48715.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L10 Gene

neXtProt entry for BCL2L10 Gene

Post-translational modifications for BCL2L10 Gene

  • Ubiquitination at Lys109 and Lys110
  • Modification sites at PhosphoSitePlus

Other Protein References for BCL2L10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCL2L10 (BCL2L10)
  • Abcam antibodies for BCL2L10
  • Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L10

No data available for DME Specific Peptides for BCL2L10 Gene

Domains & Families for BCL2L10 Gene

Gene Families for BCL2L10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for BCL2L10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD36

UniProtKB/Swiss-Prot:

B2L10_HUMAN :
  • Belongs to the Bcl-2 family.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BCL2L10: view

Function for BCL2L10 Gene

Molecular function for BCL2L10 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.

Gene Ontology (GO) - Molecular Function for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278245
GO:0042803 protein homodimerization activity IBA,IEA --
GO:0046982 protein heterodimerization activity IBA --
GO:0089720 caspase binding IPI 19255499
genes like me logo Genes that share ontologies with BCL2L10: view
genes like me logo Genes that share phenotypes with BCL2L10: view

Animal Models for BCL2L10 Gene

MGI Knock Outs for BCL2L10:

Animal Model Products

CRISPR Products

miRNA for BCL2L10 Gene

miRTarBase miRNAs that target BCL2L10

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BCL2L10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L10 Gene

Localization for BCL2L10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L10 Gene

Mitochondrion. Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL2L10 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 4
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA 11278245
GO:0005741 mitochondrial outer membrane IBA --
GO:0005829 cytosol IDA 11278245
GO:0016020 membrane IEA,TAS 9878060
genes like me logo Genes that share ontologies with BCL2L10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BCL2L10 Gene

Pathways & Interactions for BCL2L10 Gene

genes like me logo Genes that share pathways with BCL2L10: view

Pathways by source for BCL2L10 Gene

1 Cell Signaling Technology pathway for BCL2L10 Gene
1 PharmGKB pathway for BCL2L10 Gene
1 GeneGo (Thomson Reuters) pathway for BCL2L10 Gene

Gene Ontology (GO) - Biological Process for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS 9829980
GO:0007283 spermatogenesis TAS 9878060
GO:0007292 female gamete generation TAS 9878060
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
genes like me logo Genes that share ontologies with BCL2L10: view

No data available for SIGNOR curated interactions for BCL2L10 Gene

Drugs & Compounds for BCL2L10 Gene

No Compound Related Data Available

Transcripts for BCL2L10 Gene

mRNA/cDNA for BCL2L10 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BCL2L10 Gene

BCL2-like 10 (apoptosis facilitator):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BCL2L10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L10 Gene

No ASD Table

Relevant External Links for BCL2L10 Gene

GeneLoc Exon Structure for
BCL2L10
ECgene alternative splicing isoforms for
BCL2L10

Expression for BCL2L10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL2L10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L10 Gene

This gene is overexpressed in Liver (x6.4).

Protein differential expression in normal tissues from HIPED for BCL2L10 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCL2L10 Gene



Protein tissue co-expression partners for BCL2L10 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL2L10 Gene:

BCL2L10

SOURCE GeneReport for Unigene cluster for BCL2L10 Gene:

Hs.283672

mRNA Expression by UniProt/SwissProt for BCL2L10 Gene:

Q9HD36-B2L10_HUMAN
Tissue specificity: Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.

Evidence on tissue expression from TISSUES for BCL2L10 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with BCL2L10: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L10 Gene

Orthologs for BCL2L10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BCL2L10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2L10 33 34
  • 98.2 (n)
cow
(Bos Taurus)
Mammalia BCL2L10 33
  • 69.75 (n)
-- 34
  • 55 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bcl2l10 33 16 34
  • 67.03 (n)
rat
(Rattus norvegicus)
Mammalia Bcl2l10 33
  • 65.93 (n)
Species where no ortholog for BCL2L10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L10 Gene

ENSEMBL:
Gene Tree for BCL2L10 (if available)
TreeFam:
Gene Tree for BCL2L10 (if available)

Paralogs for BCL2L10 Gene

No data available for Paralogs for BCL2L10 Gene

Variants for BCL2L10 Gene

Sequence variations from dbSNP and Humsavar for BCL2L10 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000100146 -- 52,111,654(+) TGAAA(G/T)CCAGG intron-variant
rs1001396332 -- 52,111,185(+) ACACA(A/C)ACACA intron-variant
rs1001516840 -- 52,110,483(+) GGCTG(C/G)AGTGC intron-variant
rs1002493101 -- 52,109,705(+) CAAAT(C/T)ACCAC utr-variant-3-prime
rs1002525963 -- 52,111,679(+) TCACC(A/G)AGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2L10 Gene

Variant ID Type Subtype PubMed ID
nsv471244 CNV gain 18288195
nsv833005 CNV gain 17160897
nsv952627 CNV deletion 24416366

Variation tolerance for BCL2L10 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL2L10 Gene

Human Gene Mutation Database (HGMD)
BCL2L10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL2L10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L10 Gene

Disorders for BCL2L10 Gene

MalaCards: The human disease database

(7) MalaCards diseases for BCL2L10 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
prostatic cyst
  • cyst of prostate
urethral stricture
low compliance bladder
  • hyperactivity of bladder
avian influenza
  • avian flu
diverticulitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BCL2L10

Genetic Association Database (GAD)
BCL2L10
Human Genome Epidemiology (HuGE) Navigator
BCL2L10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL2L10
genes like me logo Genes that share disorders with BCL2L10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L10 Gene

Publications for BCL2L10 Gene

  1. Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. (PMID: 11278245) Ke N … Reed JC (The Journal of biological chemistry 2001) 3 4 22 60
  2. Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. (PMID: 11689480) Zhang H … De Geyter C (Human molecular genetics 2001) 3 4 22 60
  3. Boo, a novel negative regulator of cell death, interacts with Apaf-1. (PMID: 9878060) Song Q … Vincenz C (The EMBO journal 1999) 2 3 22 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60

Products for BCL2L10 Gene

Sources for BCL2L10 Gene

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