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Aliases for BCL2L10 Gene

Aliases for BCL2L10 Gene

  • BCL2-Like 10 (Apoptosis Facilitator) 2 3
  • Anti-Apoptotic Protein NrH 3 4
  • Apoptosis Regulator Bcl-B 3 4
  • Bcl2-L-10 3 4
  • Bcl-2-Like Protein 10 3
  • BCL-B 3
  • Diva 3
  • BCLB 4
  • Boo 3

External Ids for BCL2L10 Gene

Summaries for BCL2L10 Gene

Entrez Gene Summary for BCL2L10 Gene

  • The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL2L10 Gene

BCL2L10 (BCL2-Like 10 (Apoptosis Facilitator)) is a Protein Coding gene. Among its related pathways are Apoptosis (WikiPathways) and Apoptosis and Autophagy.

UniProtKB/Swiss-Prot for BCL2L10 Gene

  • Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.

Gene Wiki entry for BCL2L10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L10 Gene

Genomics for BCL2L10 Gene

Genomic Location for BCL2L10 Gene

Start:
52,109,263 bp from pter
End:
52,112,775 bp from pter
Size:
3,513 bases
Orientation:
Minus strand

Genomic View for BCL2L10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL2L10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2L10 Gene

Regulatory Elements for BCL2L10 Gene

Proteins for BCL2L10 Gene

  • Protein details for BCL2L10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD36-B2L10_HUMAN
    Recommended name:
    Bcl-2-like protein 10
    Protein Accession:
    Q9HD36
    Secondary Accessions:
    • Q3SX80
    • Q52LQ9
    • Q8TCS9

    Protein attributes for BCL2L10 Gene

    Size:
    194 amino acids
    Molecular mass:
    21973 Da
    Quaternary structure:
    • Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.
    SequenceCaution:
    • Sequence=AAG00503.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93826.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93828.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04443.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04444.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK48715.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL2L10 Gene

neXtProt entry for BCL2L10 Gene

Proteomics data for BCL2L10 Gene at MOPED

Post-translational modifications for BCL2L10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys109 and Lys110

Other Protein References for BCL2L10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL2L10 Gene

Domains for BCL2L10 Gene

Protein Domains for BCL2L10 Gene

UniProtKB/Swiss-Prot:

B2L10_HUMAN
Family:
  • Belongs to the Bcl-2 family.:
    • Q9HD36
genes like me logo Genes that share domains with BCL2L10: view

No data available for Gene Families for BCL2L10 Gene

Function for BCL2L10 Gene

Molecular function for BCL2L10 Gene

UniProtKB/Swiss-Prot Function: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.

Gene Ontology (GO) - Molecular Function for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278245
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IBA --
genes like me logo Genes that share ontologies with BCL2L10: view

Phenotypes for BCL2L10 Gene

MGI mutant phenotypes for BCL2L10:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with BCL2L10: view

Animal Models for BCL2L10 Gene

MGI Knock Outs for BCL2L10:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BCL2L10 Gene

Localization for BCL2L10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2L10 Gene

Mitochondrion. Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2L10 Gene COMPARTMENTS Subcellular localization image for BCL2L10 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005739 mitochondrion IDA 11278245
GO:0005741 mitochondrial outer membrane IBA --
GO:0005829 cytosol IDA 11278245
GO:0016020 membrane TAS 9878060
genes like me logo Genes that share ontologies with BCL2L10: view

Pathways for BCL2L10 Gene

genes like me logo Genes that share pathways with BCL2L10: view

Pathways by source for BCL2L10 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for BCL2L10 Gene
1 Cell Signaling Technology pathway for BCL2L10 Gene
1 BioSystems pathway for BCL2L10 Gene
1 PharmGKB pathway for BCL2L10 Gene

Gene Ontology (GO) - Biological Process for BCL2L10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS 9829980
GO:0007283 spermatogenesis TAS 9878060
GO:0007292 female gamete generation TAS 9878060
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0042981 regulation of apoptotic process --
genes like me logo Genes that share ontologies with BCL2L10: view

Transcripts for BCL2L10 Gene

mRNA/cDNA for BCL2L10 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BCL2L10 Gene

BCL2-like 10 (apoptosis facilitator):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L10 Gene

No ASD Table

Relevant External Links for BCL2L10 Gene

GeneLoc Exon Structure for
BCL2L10
ECgene alternative splicing isoforms for
BCL2L10

Expression for BCL2L10 Gene

mRNA expression in normal human tissues for BCL2L10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2L10 Gene

This gene is overexpressed in Liver (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BCL2L10 Gene

SOURCE GeneReport for Unigene cluster for BCL2L10 Gene Hs.283672

mRNA Expression by UniProt/SwissProt for BCL2L10 Gene

Q9HD36-B2L10_HUMAN
Tissue specificity: Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.
genes like me logo Genes that share expressions with BCL2L10: view

Orthologs for BCL2L10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BCL2L10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2L10 36
  • 98.2 (n)
  • 97.06 (a)
BCL2L10 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 48 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
BCL2L10 36
  • 69.75 (n)
  • 55.43 (a)
mouse
(Mus musculus)
Mammalia Bcl2l10 36
  • 67.03 (n)
  • 50.81 (a)
Bcl2l10 16
Bcl2l10 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl2l10 36
  • 65.93 (n)
  • 48.9 (a)
Species with no ortholog for BCL2L10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2L10 Gene

ENSEMBL:
Gene Tree for BCL2L10 (if available)
TreeFam:
Gene Tree for BCL2L10 (if available)

Paralogs for BCL2L10 Gene

No data available for Paralogs for BCL2L10 Gene

Variants for BCL2L10 Gene

Sequence variations from dbSNP and Humsavar for BCL2L10 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2227308 -- 52,109,754(-) TTCCC(C/T)CACCC utr-variant-3-prime
rs2231286 -- 52,113,496(-) ataaa(A/T)gcctt upstream-variant-2KB
rs2231287 -- 52,113,466(-) CTATG(A/G)CATTC upstream-variant-2KB
rs2231288 -- 52,113,419(-) AGTGC(C/T)GTGCC upstream-variant-2KB
rs2231289 -- 52,113,301(-) TCtgc(A/G)tcagt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BCL2L10 Gene

Variant ID Type Subtype PubMed ID
nsv471244 CNV Gain 18288195
nsv833005 CNV Gain 17160897

Relevant External Links for BCL2L10 Gene

HapMap Linkage Disequilibrium report
BCL2L10

Disorders for BCL2L10 Gene

Relevant External Links for BCL2L10

Genetic Association Database (GAD)
BCL2L10
Human Genome Epidemiology (HuGE) Navigator
BCL2L10
genes like me logo Genes that share disorders with BCL2L10: view

No data available for UniProtKB/Swiss-Prot for BCL2L10 Gene

Publications for BCL2L10 Gene

  1. Boo, a novel negative regulator of cell death, interacts with Apaf-1. (PMID: 9878060) Song Q. … Vincenz C. (EMBO J. 1999) 2 3 23
  2. Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. (PMID: 11278245) Ke N. … Reed J.C. (J. Biol. Chem. 2001) 3 4 23
  3. Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. (PMID: 11689480) Zhang H. … De Geyter C. (Hum. Mol. Genet. 2001) 3 4 23
  4. HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. (PMID: 19255499) Kim J.H. … Bae J. (Cell. Physiol. Biochem. 2009) 3 23
  5. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. (PMID: 9829980) Inohara N. … NA_A+ez G. (J. Biol. Chem. 1998) 2 3

Products for BCL2L10 Gene

Sources for BCL2L10 Gene

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