Aliases for BCL2L1 Gene
Aliases for BCL2L1 Gene
External Ids for BCL2L1 Gene
- HGNC: 992
- Entrez Gene: 598
- Ensembl: ENSG00000171552
- OMIM: 600039
- UniProtKB: Q07817
Previous GeneCards Identifiers for BCL2L1 Gene
- GC20M030040
- GC20M030950
- GC20M030997
- GC20M029715
- GC20M030252
- GC20M027040
Summaries for BCL2L1 Gene
-
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
GeneCards Summary for BCL2L1 Gene
BCL2L1 (BCL2 Like 1) is a Protein Coding gene. Diseases associated with BCL2L1 include Her2-Receptor Negative Breast Cancer and Lung Cancer. Among its related pathways are Development IGF-1 receptor signaling and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BCL2.
UniProtKB/Swiss-Prot for BCL2L1 Gene
-
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
-
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
-
Isoform Bcl-X(S) promotes apoptosis.
-
Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2L1 Gene
Genomics for BCL2L1 Gene
Regulatory Elements for BCL2L1 Gene
Enhancers for BCL2L1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around BCL2L1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for BCL2L1 Gene
- Chromosome:
- 20
- Start:
- 31,664,452 bp from pter
- End:
- 31,723,989 bp from pter
- Size:
- 59,538 bases
- Orientation:
- Minus strand
Genomic View for BCL2L1 Gene
Genes around BCL2L1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.21 by Ensembl
- 20q11.21 by Entrez Gene
- 20q11.21 by HGNC
BCL2L1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL2L1 Gene
Proteins for BCL2L1 Gene
-
Protein details for BCL2L1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07817-B2CL1_HUMAN
- Recommended name:
- Bcl-2-like protein 1
- Protein Accession:
- Q07817
- E1P5L6
- Q5CZ89
- Q5TE65
- Q92976
Protein attributes for BCL2L1 Gene
- Size:
- 233 amino acids
- Molecular mass:
- 26049 Da
- Quaternary structure:
-
- Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with BOP/C22orf29. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5A and ATP5B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase. Interacts with VDAC1 (PubMed:25296756). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785). Interacts with BCL2L11 (via BH3) (PubMed:27013495).
Three dimensional structures from OCA and Proteopedia for BCL2L1 Gene
Protein Expression for BCL2L1 Gene
Post-translational modifications for BCL2L1 Gene
- Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.
- Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
- Ubiquitination at posLast=1616 and Lys87
- Modification sites at PhosphoSitePlus
Other Protein References for BCL2L1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for BCL2L1
- R&D Systems Antibodies for BCL2L1 (Bcl-xL)
- R&D Systems Antibodies for BCL2L1 (Bcl-x)
- Cell Signaling Technology (CST) Antibodies for BCL2L1 (Bcl-xL)
-
Custom Antibody ServicesOriGene Antibodies for BCL2L1
- AM11093PU-M
- AM11093PU-N
- AM11093PU-S
- AM33365PU-N
- AM33365PU-S
- AM33365PU-T
- TA506188JM
- TA506188HM
- TA506188GM
- TA506188FM
- TA506188EM
- TA506188DM
- TA506188CM
- TA506188BM
- TA506188AM
- TA500097S
- CF506188
- TA506188
- CF500097
- TA500097
- TA353598
- TA353597
- TA353596
- TA352589
- TA336563
- TA336559
- TA333168
- TA326771
- TA325265
- TA325264
- TA325263
- TA325262
- TA324971
- TA323213
- TA323212
- TA312474
- TA312473
- TA312472
- TA312471
- TA312470
- TA308852
- TA308851
- TA306173
- AP26417AF-N
- AP26417AF-L
- AP23387PU-N
- AP15366PU-S
- AP15366PU-N
- AP15366PU-M
- AP15365PU-S
- AP15365PU-N
- AP15365PU-M
- AM50202PU-T
- AM50202PU-S
- AM50202PU-N
- AM50165PU-T
- AM50165PU-S
- AM50165PU-N
- Novus Biologicals Antibodies for BCL2L1
-
Abcam antibodies for BCL2L1
-
Cloud-Clone Corp. Antibodies for BCL2L1
- Invitrogen Antibodies for BCL2L1
- antibodies-online Antibodies for BCL2L1: See all 414
- GeneTex BCL2L1 antibody for BCL2L1
-
Custom Antibody ServicesProSci Antibodies for BCL2L1
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCL2L1
Protein Products
- R&D Systems Proteins and Enzymes for BCL2L1 (Bcl-xL)
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL2L1
- Origene Custom Protein Services for BCL2L1
- Sino Biological Recombinant Proteins for BCL2L1
- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for BCL2L1
- antibodies-online Proteins for BCL2L1: See all 25
- Search antibodies-online for peptides
- Search GeneTex for Proteins for BCL2L1
-
ProSci Proteins for BCL2L1
-
Abcam proteins for BCL2L1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for BCL2L1 (Bcl-xL)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for BCL2L1 (Bcl-x)
- antibodies-online Kits for BCL2L1: See all 22
No data available for DME Specific Peptides for BCL2L1 Gene
Domains & Families for BCL2L1 Gene
Gene Families for BCL2L1 Gene
Protein Domains for BCL2L1 Gene
Suggested Antigen Peptide Sequences for BCL2L1 Gene
Graphical View of Domain Structure for InterPro Entry
Q07817UniProtKB/Swiss-Prot:
B2CL1_HUMAN :- The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
- Belongs to the Bcl-2 family.
- Domain:
-
- The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
- The loop between motifs BH4 and BH3 is required for the interaction with NLRP1.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BCL2L1 Gene
Molecular function for BCL2L1 Gene
- UniProtKB/Swiss-Prot Function:
- Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
- UniProtKB/Swiss-Prot Function:
- Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
- UniProtKB/Swiss-Prot Function:
- Isoform Bcl-X(S) promotes apoptosis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9027312 |
| GO:0019901 | protein kinase binding | IPI | 21840391 |
| GO:0042802 | identical protein binding | IPI | 21856303 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
| GO:0051434 | BH3 domain binding | IPI | 21639858 |
Phenotypes for BCL2L1 Gene
- MGI mutant phenotypes for BCL2L1:
-
inferred from 8 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for BCL2L1:
-
- Synthetic lethal with Ras
- Lamellipodia cells
- Decreased viability in esophageal squamous lineage
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased Sindbis virus (SINV) infection
- Synthetic lethal with cisplatin
- Decreased viability with paclitaxel
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCL2L1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BCL2L1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L1 gene
- Search ViGene Biosciences for BCL2L1
CRISPR Products
-
OriGene CRISPR knockouts for BCL2L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L1
- GenScript: Design CRISPR guide RNA sequences for BCL2L1
miRNA for BCL2L1 Gene
- miRTarBase miRNAs that target BCL2L1
-
- hsa-mir-491-5p (MIRT004285)
- hsa-let-7g-5p (MIRT004490)
- hsa-let-7c-5p (MIRT004491)
- hsa-mir-122-5p (MIRT023334)
- hsa-mir-30a-5p (MIRT028457)
- hsa-mir-484 (MIRT042070)
- hsa-mir-23b-3p (MIRT046292)
- hsa-mir-133a-3p (MIRT052647)
- hsa-mir-218-5p (MIRT441111)
- hsa-mir-6858-5p (MIRT455281)
- hsa-mir-4689 (MIRT455282)
- hsa-mir-1287-3p (MIRT455283)
- hsa-mir-525-5p (MIRT455284)
- hsa-mir-520a-5p (MIRT455285)
- hsa-mir-198 (MIRT455286)
- hsa-mir-4710 (MIRT455287)
- hsa-mir-6797-5p (MIRT455288)
- hsa-mir-1249-5p (MIRT455289)
- hsa-mir-7854-3p (MIRT455290)
- hsa-mir-6133 (MIRT455291)
- hsa-mir-6130 (MIRT455292)
- hsa-mir-6129 (MIRT455293)
- hsa-mir-6127 (MIRT455294)
- hsa-mir-4510 (MIRT455295)
- hsa-mir-4419a (MIRT455296)
- hsa-mir-4784 (MIRT455297)
- hsa-mir-3150b-3p (MIRT455298)
- hsa-mir-455-3p (MIRT455299)
- hsa-mir-4779 (MIRT455300)
- hsa-mir-4257 (MIRT455301)
- hsa-mir-575 (MIRT455302)
- hsa-mir-4676-5p (MIRT455303)
- hsa-mir-6858-3p (MIRT455304)
- hsa-mir-4749-3p (MIRT528154)
- hsa-mir-587 (MIRT528155)
- hsa-mir-4313 (MIRT528156)
- hsa-mir-324-3p (MIRT528157)
- hsa-mir-1913 (MIRT528158)
- hsa-mir-1976 (MIRT528159)
- hsa-mir-6747-3p (MIRT528160)
- hsa-mir-6727-3p (MIRT528161)
- hsa-mir-4722-3p (MIRT528162)
- hsa-mir-361-3p (MIRT528163)
- hsa-mir-4691-3p (MIRT528164)
- hsa-mir-449b-3p (MIRT528165)
miRNA Products
- Search ViGene Biosciences for BCL2L1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BCL2L1
- Browse OriGene Inhibitory RNA Products For BCL2L1
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L1 gene
Clone Products
- Sino Biological Human cDNA Clone for BCL2L1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for BCL2L1
- VectorBuilder custom plasmid, inducible vectors for BCL2L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for BCL2L1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BCL2L1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL2L1 Gene
Localization for BCL2L1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCL2L1 Gene
- Isoform Bcl-X(L): Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 20673843 |
| GO:0005739 | mitochondrion | IDA | 12011449 |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
Pathways & Interactions for BCL2L1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
.33
|
| 2 | Amyotrophic lateral sclerosis (ALS) | ||
| 3 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
|
| 4 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
.01
|
|
| 5 | Nanomaterial induced apoptosis | ||
Pathways by source for BCL2L1 Gene
3 Sino Biological pathways for BCL2L1 Gene
1 GeneTex pathway for BCL2L1 Gene
1 Cell Signaling Technology pathway for BCL2L1 Gene
18 BioSystems pathways for BCL2L1 Gene
12 Reactome pathways for BCL2L1 Gene
2 PharmGKB pathways for BCL2L1 Gene
19 KEGG pathways for BCL2L1 Gene
16 GeneGo (Thomson Reuters) pathways for BCL2L1 Gene
7 R&D Systems pathways for BCL2L1 Gene
2 Tocris pathways for BCL2L1 Gene
18 Qiagen pathways for BCL2L1 Gene
Interacting Proteins for BCL2L1 Gene
Selected Interacting proteins:
Q07817-B2CL1_HUMAN
ENSP00000302564
for BCL2L1 Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for BCL2L1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000910 | cytokinesis | IMP | 21840391 |
| GO:0001541 | ovarian follicle development | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001836 | release of cytochrome c from mitochondria | IDA | 9843949 |
| GO:0006897 | endocytosis | IEA | -- |
Drugs & Compounds for BCL2L1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Lomustine | Approved | Pharma | Antineoplastic drug | 84 | ||
| Mitomycin | Approved | Pharma | Inhibits DNA synthesis,antibiotic and antitumor agent | 0 | ||
| 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | Experimental | Pharma | Target | 0 | ||
| Gossypol | Pharma | PAF inhibitor;anti-fertility and anti-cancer, Proapoptotic; downregulates Bcl-2 and Bcl-XL | 24 | |||
| (+)-Apogossypol | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Maritoclax |
|
1227962-62-0 |
|
|
||
| SMBA 1 |
|
906440-37-7 |
|
|
(5) Tocris Compounds for BCL2L1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bax channel blocker | Inhibits Bax-mediated mitochondrial cytochrome c release | 329349-20-4 |
| Gossypol | Proapoptotic; downregulates Bcl-2 and Bcl-XL | 303-45-7 |
| Maritoclax | Mcl-1 inhibitor; proapoptotic | 1227962-62-0 |
| MIM1 | Mcl-1 inhibitor; proapoptotic | |
| SMBA 1 | High affinity and selective activator of Bax | 906440-37-7 |
(21) ApexBio Compounds for BCL2L1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+)-Apogossypol | 66389-74-0 | |
| 2,3-DCPE hydrochloride | Bcl-XL protein expression downregulator | 418788-90-6 |
| ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 923564-51-6 |
| ABT-737 | Bcl-2 inhibitor | 852808-04-9 |
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Bcl Family Set I | Bcl family inhibitors | |
| BIM, Biotinylated | ||
| BM-1074 | Bcl-2/Bcl-xL inhibitor,potent and selective | 1391108-10-3 |
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
| iMAC2 | MAC inhibitor | 335166-36-4 |
| Lomustine | Antineoplastic drug | 13010-47-4 |
| Mcl1-IN-1 | Myeloid cell factor 1 inhibitor | 713492-66-1 |
| Mitomycin C | Inhibits DNA synthesis,antibiotic and antitumor agent | 1950-07-7 |
| Muristerone A | TRAIL- and hFasL-induced apoptosis inhibitor | 38778-30-2 |
| Pyridoclax | ||
| Radotinib(IY-5511) | Bcl-Abl tyrosine kinase inhibitor | 926037-48-1 |
| TW-37 | Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 | 877877-35-5 |
| WEHI-539 | Bcl-xL inhibitor,potent and selective | 1431866-33-9 |
| WEHI-539 hydrochloride | Bcl-xL inhibitor,high affinity and selective |
Drug Products
- ApexBio compounds for BCL2L1
Transcripts for BCL2L1 Gene
mRNA/cDNA for BCL2L1 Gene
- (10) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (550) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for BCL2L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL2L1
- GenScript: Design CRISPR guide RNA sequences for BCL2L1
miRNA Products
- Search ViGene Biosciences for BCL2L1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BCL2L1
- Browse OriGene Inhibitory RNA Products For BCL2L1
-
ViGene Biosciences ready-to-package AAV shRNAs for BCL2L1 gene
Clone Products
- Sino Biological Human cDNA Clone for BCL2L1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for BCL2L1
- VectorBuilder custom plasmid, inducible vectors for BCL2L1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCL2L1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for BCL2L1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epidermis (Integumentary System)
- Corneocytes Stratified Epidermis
- Granular Keratinocytes Stratified Epidermis
- Spinous Keratinocytes Stratified Epidermis
-
Epithelial Cells
- Corneocytes Stratified Epidermis
- Granular Keratinocytes Stratified Epidermis
- Spinous Keratinocytes Stratified Epidermis
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
- Double Positive Thymocytes Thymus
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Heart (Cardiovascular System)
- Bone (Muscoskeletal System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for BCL2L1 Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Breast (23.3), Bone (11.0), and Bone marrow stromal cell (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL2L1 Gene
NURSA nuclear receptor signaling pathways regulating expression of BCL2L1 Gene:
BCL2L1SOURCE GeneReport for Unigene cluster for BCL2L1 Gene:
Hs.516966mRNA Expression by UniProt/SwissProt for BCL2L1 Gene:
Q07817-B2CL1_HUMAN
Tissue specificity:
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Evidence on tissue expression from TISSUES for BCL2L1 Gene
- Lung(4.7)
- Nervous system(4.4)
- Liver(3.9)
- Intestine(3.4)
- Blood(3.1)
- Bone marrow(3.1)
- Heart(2.9)
- Kidney(2.9)
- Eye(2.8)
- Muscle(2.8)
- Lymph node(2.7)
- Pancreas(2.7)
- Skin(2.7)
- Spleen(2.6)
- Stomach(2.5)
- Adrenal gland(2.4)
- Thyroid gland(2.3)
Primer Products
-
OriGene qPCR primer pairs for BCL2L1
-
OriGene qPCR primer pairs and template standards for BCL2L1
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL2L1 Gene
Orthologs for BCL2L1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | BCL-XL 35 |
|
OneToOne | |
| BCL2L1 34 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | BCL2L1 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BCL2L1 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Bcl2l1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bcl2l1 35 16 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BCL2L1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BCL2L1 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BCL2L1 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | bcl-XL 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bcl2l1 35 34 |
|
OneToOne | |
| bcl2l 34 |
|
- Species where no ortholog for BCL2L1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BCL2L1 Gene
(5) SIMAP similar genes for BCL2L1 Gene using alignment to 6 proteins:
Variants for BCL2L1 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004123 | -- | 31,694,052(+) | TCTCT(C/G)CCTGT | intron-variant | |
| rs1000022353 | -- | 31,697,807(+) | CATAC(C/T)TCATA | intron-variant | |
| rs1000033843 | -- | 31,697,517(+) | ACTGC(A/C)ACCTC | intron-variant | |
| rs1000168398 | -- | 31,692,863(+) | AAGAT(C/T)GCACC | intron-variant | |
| rs1000213621 | -- | 31,687,344(+) | GCAAG(C/T)GAAGC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4300n100 | CNV | gain | 25217958 |
| esv2444548 | CNV | insertion | 19546169 |
| nsv458961 | CNV | gain | 19166990 |
| nsv585911 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.12;
2.67% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for BCL2L1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BCL2L1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL2L1 Gene
Disorders for BCL2L1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| her2-receptor negative breast cancer |
|
|
| lung cancer |
|
|
| pancreatic cancer |
|
|
| hepatocellular carcinoma |
|
|
| colorectal cancer |
|
Search BCL2L1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for BCL2L1
No data available for UniProtKB/Swiss-Prot and Genatlas for BCL2L1 Gene
Publications for BCL2L1 Gene
- Bax-independent inhibition of apoptosis by Bcl-XL. (PMID: 8596636) Cheng E.H.-Y. … Korsmeyer S.J. (Nature 1996) 3 4 22 64
- bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. (PMID: 8358789) Boise L.H. … Thompson C.B. (Cell 1993) 2 3 4 64
- The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. (PMID: 27013495) Weber A. … HAocker G. (EMBO Rep. 2016) 3 4 64
- Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. (PMID: 25296756) Li L. … Gao G.Q. (J. Biol. Chem. 2014) 3 4 64
- Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. (PMID: 21639858) Ambrosi E. … Monaco H.L. (Biochem. J. 2011) 3 4 64
Products for BCL2L1 Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for BCL2L1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for BCL2L1 gene
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- Custom Antibody ServicesProSci Antibodies for BCL2L1
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BCL2L1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
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- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer