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BCL2L1 Gene

protein-coding   GIFtS: 71
GCID: GC20M030252

BCL2-Like 1

Microbiology & Infectious Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
BCL2-Like 11 2     BCL-XL/S2
BCLX2 3 5     Bcl-X2
Apoptosis Regulator Bcl-X2 3     PPP1R522
BCL2L2 3     Bcl-2-Like Protein 12
BCLXL2 5     bcl-xL2
BCLXS2 5     bcl-xS2
Protein Phosphatase 11     Protein Phosphatase 1, Regulatory Subunit 522
Regulatory Subunit 521     Bcl2-L-13

External Ids:    HGNC: 9921   Entrez Gene: 5982   Ensembl: ENSG000001715527   OMIM: 6000395   UniProtKB: Q078173   
ORGUL members:         

Export aliases for BCL2L1 gene to outside databases

Previous GC identifers: GC20M030040 GC20M030950 GC20M030997 GC20M029715 GC20M027040


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCL2L1 Gene:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or
homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular
activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been
shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane
potential, and thus controls the production of reactive oxygen species and release of cytochrome C by
mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript
variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor
and the shorter form acts as an apoptotic activator. (provided by RefSeq, Jul 2008)

GeneCards Summary for BCL2L1 Gene:
BCL2L1 (BCL2-like 1) is a protein-coding gene. Diseases associated with BCL2L1 include maxillary sinus squamous cell carcinoma, and alk-negative anaplastic large cell lymphoma. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is BAK1.

UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
Function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by
blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase
activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to
cytokinesis during mitosis
Function: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery,
number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic
stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP
synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association
with DMN1L and stimulation of its GTPase activity in synaptic vesicles
Function: Isoform Bcl-X(S) promotes apoptosis

summary for BCL2L1 Gene:
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein
family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as
Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2
proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma
and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members
contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial
and other intracellular membranes.

Gene Wiki entry for BCL2L1 (BCL2-like 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCL2L1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   SREBP-1b   E2F   E2F-1   SREBP-1a   Sox9   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BCL2L1 promoter sequence
   Search Chromatin IP Primers for BCL2L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL2L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

BCL2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M030252:  view genomic region     (about GC identifiers)

Start:
30,252,255 bp from pter      End:
30,311,792 bp from pter
Size:
59,538 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817 (See protein sequence)
Recommended Name: Bcl-2-like protein 1  
Size: 233 amino acids; 26049 Da
Subunit: Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does
not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Interacts
(isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with
BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with
BOP/C22orf29. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53.
Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic
vesicles that also contains clathrin and MFF. Interacts with ATP5A and ATP5B; the interactions mediate the
association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase
Selected PDB 3D structures from and Proteopedia for BCL2L1 (see all 47):
1BXL (3D)        1G5J (3D)        1LXL (3D)        1MAZ (3D)        1R2D (3D)        1R2E (3D)    
Secondary accessions: E1P5L6 Q5CZ89 Q5TE65 Q92976
Alternative splicing: 3 isoforms:  Q07817-1   Q07817-2   Q07817-3   

Explore the universe of human proteins at neXtProt for BCL2L1: NX_Q07817

Explore proteomics data for BCL2L1 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has
    pro-apoptotic activity1
  • Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in
    G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated
    proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during
    mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during
    prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis1
  • Ubiquitination2 at Lys16, Lys87
  • Modification sites at PhosphoSitePlus

  • See BCL2L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182.1  NP_612815.1  

    ENSEMBL proteins: 
     ENSP00000365230   ENSP00000365223   ENSP00000302564   ENSP00000406203   ENSP00000411252  
     ENSP00000395545   ENSP00000390760   ENSP00000389688   ENSP00000401173   ENSP00000405563  
    Reactome Protein details: Q07817

    BCL2L1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BCL2L1 (Bcl-xL)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for BCL2L1
    OriGene Protein Over-expression Lysate for BCL2L1
    OriGene MassSpec for BCL2L1
    OriGene Custom Protein Services for BCL2L1
    GenScript Custom Purified and Recombinant Proteins Services for BCL2L1
    Novus Biologicals BCL2L1 Proteins
    Novus Biologicals BCL2L1 Lysates
    Sino Biological Recombinant Protein for BCL2L1
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    BCL2L1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2L1
    R&D Systems Antibodies for BCL2L1 (Bcl-x, Bcl-xL)
    Cell Signaling Technology (CST) Antibodies for BCL2L1  (Bcl-xL)
    OriGene Antibodies for BCL2L1
    OriGene Custom Antibody Services for BCL2L1
    Novus Biologicals BCL2L1 Antibodies
    Abcam antibodies for BCL2L1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for BCL2L1
    LSBio Antibodies in human, mouse, rat for BCL2L1

    BCL2L1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCL2L1
    R&D Systems ELISAs for BCL2L1 (Bcl-xL)         (see all)
    GenScript Custom Assay Services for BCL2L1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    Selected InterPro protein domains (see all 9):
     IPR020728 Bcl2_BH3_motif_CS
     IPR013279 Apop_reg_BclX
     IPR020717 Bcl2_BH1_motif_CS
     IPR004725 Bcl2/BclX
     IPR020726 Bcl2_BH2_motif_CS

    Graphical View of Domain Structure for InterPro Entry Q07817

    ProtoNet protein and cluster: Q07817

    2 Blocks protein domains:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
    Domain: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both
    heterodimerization with other Bcl-2 family members and for repression of cell death
    Similarity: Belongs to the Bcl-2 family


    BCL2L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B2CL1_HUMAN, Q07817
    Function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by
    blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase
    activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to
    cytokinesis during mitosis
    Function: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery,
    number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic
    stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP
    synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association
    with DMN1L and stimulation of its GTPase activity in synaptic vesicles
    Function: Isoform Bcl-X(S) promotes apoptosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10837489
    GO:0019901protein kinase binding IPI--
    GO:0042802identical protein binding IPI15131699
    GO:0042803protein homodimerization activity IBA--
    GO:0046982protein heterodimerization activity IBA--
         
    BCL2L1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for BCL2L1:
     Decreased viability  Decreased viability with pacli  Lamellipodia cells  Synthetic lethal with Ras 
     Synthetic lethal with cisplati  Upregulation of Wnt/beta-caten 

         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Bcl2l1):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     reproductive system  tumorigenesis 

    BCL2L1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BCL2L1: Bcl2l1tm1Dlo Bcl2l1tm1Cant

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL2L1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCL2L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL2L1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL2L1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCL2L1:
    hsa-mir-484 (MIRT042070), hsa-mir-30a-5p (MIRT028457), hsa-mir-23b-3p (MIRT046292), hsa-let-7c-5p (MIRT004491), hsa-mir-491-5p (MIRT004285), hsa-mir-133a-3p (MIRT052647), hsa-let-7g-5p (MIRT004490), hsa-mir-122-5p (MIRT023334)

    Block miRNA regulation of human, mouse, rat BCL2L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL2L1 (see all 60):
    hsa-miR-140-5p hsa-miR-1321 hsa-let-7d hsa-miR-330-5p hsa-let-7a-2* hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidBCL2L1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BCL2L1
    Predesigned siRNA for gene silencing in human, mouse, rat BCL2L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCL2L1

    Clone
    Products:
         
    OriGene clones in human, mouse for BCL2L1 (see all 12)
    OriGene ORF clones in mouse, rat for BCL2L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2L1 (NM_001191)
    Sino Biological Human cDNA Clone for BCL2L1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2L1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCL2L1
    Browse ESI BIO Cell Lines and PureStem Progenitors for BCL2L1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B2CL1_HUMAN, Q07817: Isoform Bcl-X(L): Mitochondrion inner membrane (By similarity). Mitochondrion outer membrane
    (By similarity). Mitochondrion matrix (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
    membrane (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasm, cytoskeleton, microtubule organizing
    center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=After
    neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a
    calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    nucleus5
    cytosol3
    endoplasmic reticulum2
    extracellular2
    plasma membrane2
    vacuole2
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    BCL2L1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCL2L1 About   (see all 55)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    Amyotrophic lateral sclerosis (ALS)0.63
    3Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO signaling pathway0.34
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for BCL2L1
        IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Apoptosis Signaling Pathways
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BCL2L1 (see all 18)
        DHA Signaling
    IL-10 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    BDNF Pathway

    1 Cell Signaling Technology (CST) Pathway for BCL2L1
        Apoptosis and Autophagy

    2 Tocris Bioscience Pathways for BCL2L1
        Akt Pathway
    Apoptosis Pathway

    Selected GeneGo (Thomson Reuters) Pathways for BCL2L1 (see all 16)
        Apoptosis and survival BAD phosphorylation
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Signal transduction AKT signaling
    Immune response CD28 signaling
    Development IGF-1 receptor signaling

    Selected BioSystems Pathways for BCL2L1 (see all 9)
        Apoptosis
    Apoptosis Modulation and Signaling
    Amyotrophic lateral sclerosis (ALS)
    IL-4 signaling Pathway
    IL-3 Signaling Pathway

    2 Sino Biological Pathways for BCL2L1
        p53 Pathway
    Death Receptor Signaling

    2 Reactome Pathways for BCL2L1
        The NLRP1 inflammasome
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

    1 PharmGKB Pathway for BCL2L1
        Busulfan Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for BCL2L1) (see all 13):
        Ras signaling pathway
    NF-kappa B signaling pathway
    PI3K-Akt signaling pathway
    Apoptosis
    Jak-STAT signaling pathway


    BCL2L1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL2L1 (see all 22): 
              Insulin Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL2L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCL2L1 (Q078171, 2, 3 ENSP000003025644) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BADQ929341, 2, 3, ENSP000003091034EBI-287195,EBI-700771 MINT-14701 MINT-14699 MINT-14700 MINT-7033976 I2D: score=8 STRING: ENSP00000309103
    BAXQ078121, 2, 3, ENSP000002932884EBI-287195,EBI-516580 MINT-4980301 MINT-4980319 I2D: score=8 STRING: ENSP00000293288
    TP53P046371, 2, 3, ENSP000002693054EBI-287195,EBI-366083 MINT-8249399 I2D: score=6 STRING: ENSP00000269305
    BCL2L11O435211, 2, 3EBI-287195,EBI-526406 MINT-4980301 MINT-4980319 I2D: score=10 
    BAK1Q166111, 3, ENSP000003635914EBI-287195,EBI-519866 I2D: score=6 STRING: ENSP00000363591
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP--
    GO:0001541ovarian follicle development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001836release of cytochrome c from mitochondria IDA9843949
    GO:0006897endocytosis IEA--

    BCL2L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for BCL2L1
    Selected ApexBio Compounds for BCL2L1 (see all 19)     About this table
    CompoundAction CAS #
    2,3-DCPE hydrochlorideSelectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro[418788-90-6]
    ABT-199Selective Bcl-2 inhibitor[1257044-40-8]
    ABT-263 (Navitoclax)orally sellecitive inhibitor of Bcl-2 family proteins[923564-51-6]
    ABT-737novel and potent inhibitor of BCL-2 family proteins[852808-04-9]
    Apogossypolone (ApoG2)pan Bcl-2 inhibitor[886578-07-0]
    AT-101R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1[90141-22-3]
    Bax channel blockerPotent inhibitor of Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide P5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-83-4]
    Bax inhibitor peptide V5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-81-2]
    Bax inhibitor peptide, negative controlNegative control peptide for the Bax inhibitor peptides V5 and P5[1315378-74-5]

    Compounds for BCL2L1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AT 101Downregulates Bcl-2 and Mcl-1; pro-apoptotic[90141-22-3]
    HA14-1Bcl-2 inhibitor. Induces apoptosis[65673-63-4]
    MIM1Mcl-1 inhibitor; proapoptotic--
    Bax channel blockerInhibits Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide V5Inhibitor of Bax-mediated apoptosis[579492-81-2]

    1 DrugBank Compound for BCL2L1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for BCL2L1 gene (see all 148)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 74.7 32 20051518 (2), 19366803 (1), 16273296 (1), 18418772 (1) (see all 19)
    adpribose 64.6 13 11205313 (1), 14520473 (1), 14966908 (1), 15176047 (1) (see all 12)
    etoposide 64.5 33 10620629 (3), 12553012 (2), 10839193 (2), 9242554 (1) (see all 25)
    gossypol 61.7 35 15657350 (4), 16258364 (4), 16020667 (3), 15657349 (3) (see all 10)
    sp 600125 60.8 3 18281123 (1), 19747539 (1)
    bortezomib 60.4 11 18594829 (2), 20051518 (2), 19372569 (1), 15767553 (1) (see all 9)
    paclitaxel 60.1 81 10516758 (6), 16080463 (5), 18281549 (4), 8853905 (4) (see all 36)
    dutp 59.4 9 20410588 (1), 15182618 (1), 15671112 (1), 11485911 (1) (see all 7)
    doxorubicin 58.5 47 19502069 (3), 17923112 (2), 15893350 (2), 17140381 (2) (see all 27)
    cisplatin 58.4 126 16331250 (5), 17848273 (5), 17275076 (4), 16020667 (4) (see all 57)



    BCL2L1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for BCL2L1 gene (2 alternative transcripts): 
    NM_001191.2  NM_138578.1  

    Unigene Cluster for BCL2L1:

    BCL2-like 1
    Hs.516966  [show with all ESTs]
    Unigene Representative Sequence: CR936637
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376062(uc002wwk.3) ENST00000376055(uc002wwm.3) ENST00000307677(uc002wwl.3 uc002wwn.3)
    ENST00000450273 ENST00000422920 ENST00000456404 ENST00000420488(uc002wwo.1)
    ENST00000439267 ENST00000434194 ENST00000420653
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BCL2L1 (see all 60):
    hsa-miR-140-5p hsa-miR-1321 hsa-let-7d hsa-miR-330-5p hsa-let-7a-2* hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidBCL2L1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2L1 (NM_001191)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2L1
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    OriGene qSTAR qPCR primer pairs in human, mouse for BCL2L1
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      QuantiTect SYBR Green Assays in human, mouse, rat BCL2L1
      Search QuantiFast Probe-based Assays in human, mouse, rat BCL2L1

    Additional mRNA sequence: 

    AK290968.1 AY263335.1 AY263336.1 AY263337.1 BC019307.1 BT007208.1 BX647525.1 CR936637.1 
    Z23115.1 Z23116.1 

    24 DOTS entries:

    DT.101984602  DT.100824803  DT.100033618  DT.92454063  DT.95322400  DT.95277896  DT.97857304  DT.100824816 
    DT.97860277  DT.95277878  DT.100824811  DT.100824805  DT.100824807  DT.101959134  DT.91851155  DT.100033609 
    DT.100824812  DT.100824814  DT.120812945  DT.92454062  DT.100033608  DT.100680697  DT.120812879  DT.92454059 

    Selected AceView cDNA sequences (see all 550):

    BE900510 BE395937 BM985334 BM766010 BQ962018 AA325263 AA323426 AI082481 
    BU854765 BU157566 BQ648169 BG479739 CA306195 BQ647522 BQ646844 CB118773 
    BQ935725 BQ073511 BU553275 BU157728 BM761971 AA485184 BM905690 BI824161 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:        -     -     -     -     -     -                             -     -                                       
    SP2:                    -     -     -                                   -     -                                       
    SP3:                    -     -     -     -                             -     -                                       
    SP4:                                                                    -                                             
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for BCL2L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BCL2L1 expression in normal human tissues (normalized intensities)      BCL2L1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTCCAGC
    BCL2L1 Expression
    About this image


    BCL2L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Epithelial Cells
             Spinous Keratinocytes Stratified Epidermis
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Spinous Keratinocytes Stratified Epidermis
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Erythroblasts Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    BCL2L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL2L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516966

    UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
    Tissue specificity: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as
    developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such
    as adult brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL2L1 (see all 22): 
              Insulin Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat

    Primer
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    Search QuantiFast Probe-based Assays in human, mouse, rat BCL2L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2L1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl2l11 , 5 BCL2-like 11, 5 93.56(n)1
    97.85(a)1
      2 (75.41 cM)5
    120481  NM_009743.41  NP_033873.31 
     1527806685 
    chicken
    (Gallus gallus)
    Aves BCL2L11 BCL2-like 1 75.55(n)
    74.67(a)
      373954  NM_001025304.1  NP_001020475.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL2L16
    BCL2-like 1
    65(a)
    1 ↔ 1
    GL343768.1(108479-119718)
    African clawed frog
    (Xenopus laevis)
    Amphibia bcl-XL2 bcl-XL protein 75.25(n)    X82461.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bcl2l2 bcl2-like 74.14(n)   114401  AF317837.1 


    ENSEMBL Gene Tree for BCL2L1 (if available)
    TreeFam Gene Tree for BCL2L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCL2L1 gene
    BAK12  BCL22  BCL2L22  
    5 SIMAP similar genes for BCL2L1 using alignment to 6 protein entries:     B2CL1_HUMAN (see all proteins):
    BCL2L2-PABPN1    BCL2L2    BCL2    bcl-2    BAX

    BCL2L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCL2L1 (see all 986)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs586388301,2
    C--30252179(+) GGCAG-/CAGAGCCA 2 -- ds50010--------
    rs30736821,2
    C--30255288(+) TGTGT-/GT/GTGTGTGTGT/G
    TGTGTGTGTGTGTGTGT
    AAAAT
    4 -- int1 cds11NA 2
    rs1878294201,2
    --30264966(+) CACTTC/TGTTTT 2 -- ds50010--------
    rs1380618711,2
    --30264970(+) TTGTTC/TTTCTT 2 -- ds50010--------
    rs60605811,2
    C,H--30265006(+) accttC/Ttgatg 2 -- ds50016Minor allele frequency- T:0.00NS EA NA 422
    rs1425765431,2
    --30265014(+) ATGGGC/TGAGGA 2 -- ds50010--------
    rs73445541,2
    C,H--30265046(+) acaCCC/TTACAG 2 -- ds50015Minor allele frequency- T:0.00NS EA NA 418
    rs739036271,2
    C--30265164(+) GCAGAG/ACTCAG 2 -- ds50012Minor allele frequency- A:0.04WA 120
    rs1447471711,2
    --30265298(+) GTCACC/TGTACA 2 -- ds50010--------
    rs1925083351,2
    --30265299(+) TCACCA/GTACAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for BCL2L1 (30252255 - 30311792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BCL2L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2444548CNV Insertion19546169
    nsv458961CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing BCL2L1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing BCL2L1
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL2L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600039    OMIM disorders: --

    Selected diseases for BCL2L1 (see all 151):    About MalaCards
    maxillary sinus squamous cell carcinoma    alk-negative anaplastic large cell lymphoma    natural killer cell leukemia    extramedullary plasmacytoma
    dysembryoplastic neuroepithelial tumor    retinal ischemia    basaloid squamous cell carcinoma    malignant mesothelioma
    ganglioglioma    erythrocytosis    myeloma    ewing's family of tumors
    hepatoblastoma    polycythemia vera    peripheral vascular disease    large granular lymphocyte leukemia
    polycythemia    varicose veins    balanitis    familial colorectal cancer

    13 diseases from the University of Copenhagen DISEASES database for BCL2L1:
    Leukemia     Lymphoma     Multiple myeloma     Vascular disease
    Carcinoma     Hepatocellular carcinoma     Colorectal cancer     Prostate cancer
    Lung cancer     Melanoma     Malignant glioma     Ovarian cancer
    Breast cancer

    BCL2L1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for BCL2L1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 69 352 19209227 (6), 9060818 (5), 8909234 (4), 17699103 (4) (see all 99)
    cancer 65.1 136 14613034 (4), 19883274 (4), 12915656 (3), 12120204 (3) (see all 91)
    leukemia 60 37 11961058 (2), 10516758 (2), 11523242 (2), 16219908 (2) (see all 30)
    necrosis 56.8 42 11292287 (2), 19331832 (2), 9209397 (2), 17011514 (1) (see all 36)
    colon cancer 54.6 31 17534896 (4), 18200666 (2), 15314290 (2), 15205359 (2) (see all 23)
    prostate cancer 52.9 61 11929841 (4), 16794010 (3), 18196538 (3), 12633850 (3) (see all 30)
    myeloid leukemia 50.1 9 9204972 (2), 11410409 (1), 14726688 (1), 19676104 (1) (see all 7)
    lymphoma 49.4 54 11869534 (4), 8616083 (3), 12969962 (3), 17096886 (3) (see all 28)
    myeloma 49.3 21 10583232 (4), 9163609 (2), 15970928 (1), 9664139 (1) (see all 15)
    pancreatic cancer 49.1 26 16258364 (4), 10658530 (2), 15841044 (2), 15781649 (2) (see all 15)

    Genetic Association Database (GAD): BCL2L1
    Human Genome Epidemiology (HuGE) Navigator: BCL2L1 (15 documents)
    Tumor Gene Database (TGDB): BCL2L1

    Export disorders for BCL2L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for BCL2L1 gene, integrated from 10 sources (see all 2168):
    (articles sorted by number of sources associating them with BCL2L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. (PubMed id 8358789)1, 2, 3 Boise L.H.... Thompson C.B. (Cell 1993)
    2. Bax-independent inhibition of apoptosis by Bcl-XL. (PubMed id 8596636)1, 2, 9 Cheng E.H.-Y....Korsmeyer S.J. (Nature 1996)
    3. Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis. (PubMed id 12161031)1, 4, 9 Kuhlmann T....BrA1ck W. (J. Neuroimmunol. 2002)
    4. Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. (PubMed id 21840391)1, 2 Wang J.... Bertrand R. (Cell. Signal. 2011)
    5. Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. (PubMed id 21639858)1, 2 Ambrosi E....Monaco H.L. (Biochem. J. 2011)
    6. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. (PubMed id 19917720)1, 2 Terrano D.T.... Chambers T.C. (Mol. Cell. Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 598 HGNC: 992 AceView: BCL2L1 Ensembl:ENSG00000171552 euGenes: HUgn598
    ECgene: BCL2L1 Kegg: 598 H-InvDB: BCL2L1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BCL2L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL2L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCL2L1 gene:
    Search GeneIP for patents involving BCL2L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
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     Browse ESI BIO Cell Lines and PureStem Progenitors for BCL2L1
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L1
     SwitchGear 3'UTR luciferase reporter plasmids for BCL2L1
     SwitchGear Promoter luciferase reporter plasmids for BCL2L1
     ThermoFisher Antibody for BCL2L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2L1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL2L1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCL2L1
     LSBio Antibodies in human, mouse, rat for BCL2L1
    Customized transgenic rodents for:
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     ApexBio compounds for BCL2L1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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