V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

BCL2L1 Gene

protein-coding GIFtS: 69

GC20M029715

BCL2-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCL-XL/S ^²
BCL2L ^¹, ², ³
BCLX ^¹, ², ³
Bcl-X ^¹, ²
Bcl2-L-1 ^³
DKFZp781P2092 ^²
OTTHUMP00000030550 ^²
OTTHUMP00000030551 ^²
OTTHUMP00000030553 ^²
bcl-xL ^¹, ²
bcl-xS ^¹, ²

Descriptions
Apoptosis regulator Bcl-X ^³
BCL2-like 1 ^²

External Ids
HGNC: 992¹
Entrez Gene: 598²
UniProtKB: Q07817³
Ensembl: ENSG00000171552⁷

Search outside databases for aliases for BCL2L1 gene

Previous GC identifers: GC20M030040 GC20M030950 GC20M030997

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BCL2L1:

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form

hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide

variety of cellular activities. The proteins encoded by this gene are located at the outer

mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel

(VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production

of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the

potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode

distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the

shorter form acts as an apoptotic activator. [provided by RefSeq]

UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817

Function: Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by

association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to

regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and

preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane.

The Bcl-X(S) isoform promotes apoptosis

Gene Wiki entry for BCL2L1 (BCL2-like_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BCL2L1 gene

Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21

BCL2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M029715: (about GC identifiers)

Start:	29,715,916 bp from pter
End:	29,774,324 bp from pter
Size:	58,409 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_028392.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817 (See protein sequence)

Recommended Name: Bcl-2-like protein 1

Size: 233 amino acids; 26049 Da

Subunit: Bcl-X(L) forms homodimers, and heterodimers with BAX, BAK and BCL2. Heterodimerization

with BAX does not seem to be required for anti-apoptotic activity. Also interacts with BAD and

BBC3. Isoform Bcl-X(L) binds to Siva isoform 1. Interacts with BCL2L11 (By similarity). Interacts

with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with BAX isoform Sigma

Subcellular location: Mitochondrion membrane; Single-pass membrane protein (By similarity). Nucleus

membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Note=Mitochondrial

membranes and perinuclear envelope (By similarity)

PDB structures from and Proteopedia :

1BXL (3D)

1G5J (3D)

1LXL (3D)

1MAZ (3D)

1R2D (3D)

1R2E (3D)

1R2G (3D)

1R2H (3D)

1R2I (3D)

1YSG (3D)

1YSI (3D)

1YSN (3D)

2B48 (3D)

2O1Y (3D)

2O2M (3D)

2O2N (3D)

2P1L (3D)

2PON (3D)

2YXJ (3D)

3CVA (3D)

3FDL (3D)

3FDM (3D)

Secondary accessions: Q5CZ89 Q5TE65 Q92976

Alternative splicing: 3 isoforms: Q07817-1 Q07817-2 Q07817-3

Post-translational modifications:

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif,

has pro-apoptotic activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001182.1 NP_612815.1

ENSEMBL proteins:

ENSP00000302564 ENSP00000365230 ENSP00000365223 ENSP00000365228

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for BCL2L1
	R&D Systems Recombinant & Natural Proteins for BCL2L1 (Bcl-xL)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BCL2L1)
	Human Recombinant Proteins from Abnova (BCL2L1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IDA	12011449
GO:0005741	mitochondrial outer membrane	NAS	12667443
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for BCL2L1:

	Invitrogen Antibodies for BCL2L1
	Millipore Mono- and Polyclonal Antibodies for the study of BCL2L1
	Sigma-Aldrich Antibody Arrays and Antibodies for BCL2L1
	R&D Systems Antibodies for BCL2L1 (Bcl-x, Bcl-xL)
	Cell Signaling Technology (CST) Antibodies for BCL2L1 (Bcl-XL)
	Antibodies from Abcam (BCL2L1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BCL2L1)
	Novus Biologicals Antibodies for BCL2L1

Assays for BCL2L1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for BCL2L1 (Bcl-xL) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q07817

ProtoNet protein and cluster: Q07817

2 Blocks protein families:

IPB000712 Apoptosis regulator Bcl-2 protein

IPB003093 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817

Domain: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required

for both heterodimerization with other Bcl-2 family members and for repression of cell death

Similarity: Belongs to the Bcl-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL2L1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCL2L1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138578

Applied Biosystems Silencer® siRNAs for BCL2L1

Sigma-Aldrich siRNA and siRNA Panels for BCL2L1

Sigma-Aldrich shRNA Panels and shRNA for BCL2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BCL2L1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001191
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001191
untagged cDNA clones in CMV expression vector (see all 2): NM_001191

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_138578

UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817

Function: Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by

association with SIVA isoform 1. Inhibits activation of caspases (By similarity). Appears to

regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and

preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane.

The Bcl-X(S) isoform promotes apoptosis

11 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Bcl2l1):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	hematopoietic system
immune system	lethality-prenatal/perinatal	nervous system	reproductive system	skin/coat/nails
tumorigenesis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042802	identical protein binding	IPI	15131699

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/19 Sigma-Aldrich "Your Favorite Gene" Pathways for BCL2L1 (Your Favorite Gene powered by Ingenuity) (see all 19 )

GM-CSF Signaling
IL-15 Signaling
p53 Signaling
PTEN Signaling
CD27 Signaling in Lymphocytes

GeneDecks BCL2L1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BCL2L1

5/207 Interacting proteins for BCL2L1 (ENSP00000365230³ Q07817^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 207 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BBC3	Q9BXH1¹	STRING (score=.999) EBI-287195, EBI-519884
BCAP31	P51572¹	STRING (score=.833) EBI-78035, EBI-77683
BID	P55957¹	STRING (score=.998) EBI-287195, EBI-519672
BIK	Q13323¹	STRING (score=.999) EBI-287195, EBI-700794
HRK	O00198¹	STRING (score=.999) EBI-287195, EBI-701322

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001836	release of cytochrome c from mitochondria	IDA	9843949
GO:0006916	anti-apoptosis	IDA	12011449 16608847
GO:0008634	negative regulation of survival gene product expression	TAS	8358789
GO:0042981	regulation of apoptosis	IEA	--
GO:0046902	regulation of mitochondrial membrane permeability	IDA	9843949

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for BCL2L1

Browse Small Molecules at Sigma-Aldrich

Compounds for BCL2L1 available from Tocris Bioscience

Compound	Action	CAS number
2,3-DCPE hydrochloride	Selectively induces cancer cell apoptosis	[418788-90-6]
Gossypol	Pro-apoptotic; downregulates Bcl-2 and Bcl-XL	[303-45-7]
HA14-1	Bcl-2 inhibitor. Induces apoptosis	[65673-63-4]

About this table

10/49 Novoseek chemical compound relationships for BCL2L1 gene (see all 49 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
noxa	69.38	14	19366803 (1), 16273296 (1), 18418772 (1), 17569614 (1) (see all 13)
sp 600125	58.85	2	18281123 (1)
dutp	58.41	7	15182618 (1), 15671112 (1), 11485911 (1), 16712812 (1) (see all 6)
antimycin a3	57.76	2	17273826 (1)
ceramide	52.82	37	9841888 (5), 11801602 (4), 12387875 (3), 10196212 (3) (see all 17)
pd-184352	51.81	3	17218385 (1), 11431348 (1), 14645670 (1)
phosphatidylinositol	49.42	18	11756417 (3), 9092570 (2), 11098053 (2), 19223576 (1) (see all 12)
chalcone	46.89	1	17845507 (1)
pd 98,059	46.54	5	16911523 (1), 10516758 (1), 15459189 (1), 11098053 (1) (see all 5)
wortmannin	45.33	11	12894518 (5), 10698527 (1), 16500719 (1), 15120184 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL2L1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCL2L1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138578

Sigma-Aldrich siRNA and siRNA Panels for BCL2L1

Sigma-Aldrich shRNA Panels and shRNA for BCL2L1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001191 NM_138578

REFSEQ mRNAs for BCL2L1 gene (2 alternative transcripts):

NM_001191.2 NM_138578.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001191 NM_138578

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001191
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001191
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001191

Additional cDNA sequence:

AK290968.1 AY263335.1 AY263336.1 AY263337.1 BC019307.1 BT007208.1 BX647525.1 CR936637.1

Z23115.1 Z23116.1

24 DOTS entries:

DT.101984602 DT.100824803 DT.100033618 DT.92454063 DT.95277896 DT.95322400 DT.101959134 DT.97857304

DT.100824812 DT.100824811 DT.100824816 DT.100824805 DT.92454059 DT.97860277 DT.91851155 DT.120812879

DT.95277878 DT.100824807 DT.100033609 DT.100824814 DT.120812945 DT.100033608 DT.100680697 DT.92454062

24/550 AceView cDNA sequences (see all 550 ):

BQ636684 BQ653872 BG479739 BI824161 BE395937 BF476362 BQ645057 BM920667

AA883070 BQ646713 BU168984 BQ654165 BG746689 R05464 BU157566 BQ647522

BQ646844 BM549716 BQ648110 AA323426 BU528551 BM842543 BQ070711 BM820164

highest scoring ESTs for BCL2L1:

AY263335 AY263336 BC019307 BE788685 BF128036 BG752203 BG764073 BI022254 BI824161 BM543578

Unigene Cluster for BCL2L1:

BCL2-like 1

Hs.516966 [show with all ESTs]

Unigene Representative Sequence: CR936637

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L1 (see all 8 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f
SP1:			-		-		-		-		-		-										-		-
SP2:							-		-		-												-		-
SP3:							-		-		-		-										-		-
SP4:																							-
SP5:											-

About this scheme

ECgene alternative splicing isoforms for BCL2L1

4 Ensembl transcripts including schematic representations:

ENST00000307677 ENST00000376062 ENST00000376055 ENST00000376060

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BCL2L1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCL2L1

¹ / ² / ³

9 probe-sets matching BCL2L1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1615_at²^{, 3}	U95-A	1	1.00	1.00	0.80	0.78	Z23115	0.80	1.00	0.91	1
65477_at²^{, 3}	U95-C	1	1.00	1.00	0.92	1.41	T15735	0.60	1.00	0.82	1
34742_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.81	Z23115	0.80	1.00	0.91	1
215037_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212312_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
206665_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001191	0.60	1.00	0.82	1
215037_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212312_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206665_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BCL2L1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGTCCAGC

SOURCE GeneReport for Unigene cluster: Hs.516966
Expression variation in blood from EXPOLDB for BCL2L1
UniProtKB/Swiss-Prot: B2CL1_HUMAN, Q07817
Tissue specificity: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of
turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing
long-lived postmitotic cells, such as adult brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BCL2L1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCL2L1¹	--	BCL2-like 1	96.57(n) 100(a)	403618 NM_001003072.1 NP_001003072.1
chimpanzee (Pan troglodytes)	BCL2L1¹	--	BCL2-like 1	99.86(n) 100(a)	458156 XM_514565.2 XP_514565.2
cow (Bos taurus)	BCL2L1¹	--	BCL2-like 1	94.99(n) 97.85(a)	282152 NM_001077486.1 NP_001070954.1
rat (Rattus norvegicus)	Bcl2l1¹	--	Bcl2-like 1	93.85(n) 97.85(a)	24888 NM_001033670.1 NP_001028842.1
mouse (Mus musculus)	Bcl2l1^{1, 5}	2 (87.50 cM)⁵	BCL2-like 1^{1, 5}	93.56(n)¹ 97.85(a)¹	12048¹ NM_009743.4¹ NP_033873.3¹ AF088904⁵ AF133279⁵ (see all 31)

About this table Species with no ortholog for BCL2L1

ENSEMBL Gene Tree for BCL2L1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BCL2L1 gene

BCL2L7P1² BCL2L2² BCL2² BAX²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/288 NCBI SNPs in BCL2L1 are shown (see all 288 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 105)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6060581^1,2	C,H	29715483(+)	`accttC/Ttgatg`	2	--	ng5¹		4	EU EA WA	418
--	rs11550473^1,2	H	29773493(-)	`GCCCCG/ACGGTG`	2	T/A	mis¹ ese³		4	EU EA WA	406
	rs7362890^1,2	H	29717447(+)	`GAACCA/CCGCCG`	2	V/G	mis¹		4	EU EA WA	416
	rs7344554^1,2	H	29715523(+)	`acaCCC/TTACAG`	2	--	ng5¹		4	EU EA WA	416
--	rs17122905^1,2	F	29775219(-)	`CCCCCC/TACGGC`	2	--	ng3¹		2	MN EA	356
	rs6087772^1,2	H	29774094(+)	`TCCGCC/TTTAGG`	2	--	ut5¹ ese³		4	EU EA WA	416
	rs6119652^1,2	A,C,F,H	29723106(+)	`GTGAGC/GAAGGC`	2	--	int¹		7	EU EA WA NA	562
	rs6060627^1,2	A,C,F,H	29725820(+)	`ATGATC/TTGTGA`	2	--	int¹		7	EU EA WA NA	560
	rs6060633^1,2	A,C,F,H	29726978(+)	`AGTGAG/TGTTTG`	2	--	int¹		4	EU EA WA	416
	rs6121172^1,2	A,C,F,H	29759756(+)	`GGAAGA/CAGCAG`	2	--	int¹ trp³		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for BCL2L1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600039

10/93 Novoseek disease relationships for BCL2L1 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	67.42	338	19209227 (6), 9060818 (5), 8909234 (4), 17699103 (4) (see all 99)
cancer	63.35	126	14613034 (4), 12915656 (3), 12120204 (3), 16081848 (3) (see all 86)
leukemia	58.46	33	11961058 (2), 10516758 (2), 11523242 (2), 16219908 (2) (see all 26)
necrosis	56.68	38	11292287 (2), 9209397 (2), 17011514 (1), 8616866 (1) (see all 33)
colon cancer	54.22	31	17534896 (4), 18200666 (2), 15314290 (2), 15205359 (2) (see all 23)
prostate cancer	52.50	57	11929841 (4), 16794010 (3), 18196538 (3), 12633850 (3) (see all 29)
myeloid leukemia	49.81	8	9204972 (2), 11410409 (1), 14726688 (1), 8853905 (1) (see all 6)
lymphoma	48.59	47	11869534 (4), 8616083 (3), 12969962 (3), 17096886 (3) (see all 23)
myeloma	48.52	21	10583232 (4), 9163609 (2), 15970928 (1), 9664139 (1) (see all 15)
hnscc	46.31	27	17971900 (4), 17848273 (4), 18566236 (3), 19246337 (3) (see all 11)

About this table

Genetic Association Database: BCL2L1
Human Genome Epidemiology Navigator: BCL2L1 (5 documents)
Tumor Gene Database: BCL2L1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1708 PubMed articles for BCL2L1 gene (see all 1708 ):

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. (PubMed id 8358789)^{2, 3, 4} Boise L.H.... Thompson C.B. (1993)
Bax-independent inhibition of apoptosis by Bcl-XL. (PubMed id 8596636)^{1, 3, 4} Cheng E.H.-Y....Korsmeyer S.J. (1996)
Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis. (PubMed id 12161031)^{1, 3, 6} Kuhlmann T....Bruck W. (2002)
BCL-XL dimerization by three-dimensional domain swapping. (PubMed id 16368107)^{3, 4} O'Neill J.W.... Hockenbery D.M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. (PubMed id 12011449)^{3, 4} Xue L.... Prasad K.V.S. (2002)
PUMA induces the rapid apoptosis of colorectal cancer cells. (PubMed id 11463391)^{3, 4} Yu J.... Vogelstein B. (2001)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. (PubMed id 11206074)^{3, 4} Petros A.M....Fesik S.W. (2000)
Modulation of cell death by Bcl-xL through caspase interaction. (PubMed id 9435230)^{3, 4} Clem R.J....Hardwick J.M. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 598	HGNC: 992	AceView: BCL2L1	Ensembl:ENSG00000171552	euGenes: HUgn598
ECgene: BCL2L1	H-InvDB: BCL2L1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BCL2L1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BCL2L1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BCL2L1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BCL2L1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BCL2L1		Antibodies for BCL2L1
	Explore super-pooled esiRNAs		Proteins for BCL2L1
	Lentivirus-delivered shRNAs for BCL2L1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BCL2L1)
	Antibodies (BCL2L1)
	Chimera RNAi (BCL2L1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for BCL2L1 (Bcl-XL)

	Recombinant Proteins (BCL2L1)
	Antibodies (BCL2L1)

Search OriGene for BCL2L1

Tocris compounds for BCL2L1

	Drugs for BCL2L1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BCL2L1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BCL2L1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

BCL2L1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for BCL2L1

Summaries
for BCL2L1

Genomic Location
for BCL2L1

Proteins
for BCL2L1

Protein Domains/
Families
for BCL2L1

Gene Function
for BCL2L1

Pathways & Interactions
for BCL2L1

Drugs & Compounds
for BCL2L1

Transcripts
for BCL2L1

Expression
for BCL2L1

Orthologs
for BCL2L1

Paralogs
for BCL2L1

SNPs/Variants
for BCL2L1

Disorders & Mutations
for BCL2L1

Medical News
for BCL2L1

Publications
for BCL2L1

Search for BCL2L1

Genome Databases showing BCL2L1

Other Databases showing BCL2L1

Specialized Databases showing BCL2L1

Licensable Technologies
for BCL2L1

Services
for BCL2L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BCL2L1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor BCL2L1

Summariesfor BCL2L1

Genomic Locationfor BCL2L1

Proteinsfor BCL2L1

Protein Domains/Familiesfor BCL2L1

Gene Functionfor BCL2L1

Pathways & Interactionsfor BCL2L1

Drugs & Compoundsfor BCL2L1

Transcriptsfor BCL2L1

Expression for BCL2L1

Orthologsfor BCL2L1

Paralogsfor BCL2L1

SNPs/Variantsfor BCL2L1

Disorders & Mutationsfor BCL2L1

Medical Newsfor BCL2L1

Publicationsfor BCL2L1

Search for BCL2L1

Genome Databases showing BCL2L1

Other Databases showing BCL2L1

Specialized Databases showing BCL2L1

Licensable Technologiesfor BCL2L1

Servicesfor BCL2L1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BCL2L1

Summaries
for BCL2L1

Genomic Location
for BCL2L1

Proteins
for BCL2L1

Protein Domains/
Families
for BCL2L1

Gene Function
for BCL2L1

Pathways & Interactions
for BCL2L1

Drugs & Compounds
for BCL2L1

Transcripts
for BCL2L1

Expression
for BCL2L1

Orthologs
for BCL2L1

Paralogs
for BCL2L1

SNPs/Variants
for BCL2L1

Disorders & Mutations
for BCL2L1

Medical News
for BCL2L1

Publications
for BCL2L1

Licensable Technologies
for BCL2L1

Services
for BCL2L1