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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL2A1 Gene

protein-coding   GIFtS: 66
GCID: GC15M080256

BCL2-Related Protein A1


(Previous symbol: HBPA1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2-Related Protein A11 2     ACC-12
HBPA11 2 3     ACC-22
Bcl-2-Like Protein 52 3     Bcl-2-Related Protein A12
Hemopoietic-Specific Early Response Protein2 3     bcl2-L-52
Protein BFL-12 3     Hematopoietic BCL2-Related Protein A12
BCL2L52 3     Bcl2-L-53
BFL12 3     Protein GRS3
GRS2 3     

External Ids:    HGNC: 9911   Entrez Gene: 5972   Ensembl: ENSG000001403797   OMIM: 6010565   UniProtKB: Q165483   

Export aliases for BCL2A1 gene to outside databases

Previous GC identifers: GC15M076214 GC15M073410 GC15M077829 GC15M077969 GC15M078040 GC15M057011


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2A1 Gene:
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and
act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as
embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the
release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct
transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different
extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and
inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte
activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BCL2A1 Gene: 
BCL2A1 (BCL2-related protein A1) is a protein-coding gene. Diseases associated with BCL2A1 include somatization disorder, and glucocorticoid resistance, and among its related super-pathways are p53 Mediated Apoptosis and Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548
Function: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to
external signals and in maintaining endothelial survival during infection (By similarity)

Gene Wiki entry for BCL2A1 (BCL2-related protein A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL2A1 gene promoter:
         CREB   c-Fos   TBP   C/EBPbeta   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24.3

BCL2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2A1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M080256:  view genomic region     (about GC identifiers)

Start:
80,253,231 bp from pter      End:
80,263,788 bp from pter
Size:
10,558 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548 (See protein sequence)
Recommended Name: Bcl-2-related protein A1  
Size: 175 amino acids; 20132 Da
Subunit: Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with BCL2L11/BIM.
Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. Interacts with BOP/C22orf29
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for BCL2A1:
2VM6 (3D)        3I1H (3D)        3MQP (3D)    
Secondary accessions: Q6FGZ4 Q6FH19 Q86W13 Q99524
Alternative splicing: 2 isoforms:  Q16548-1   Q16548-2   

Explore the universe of human proteins at neXtProt for BCL2A1: NX_Q16548

Explore proteomics data for BCL2A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16548

  • BCL2A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCL2A1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001108207.1  NP_004040.1  

    ENSEMBL proteins: 
     ENSP00000267953   ENSP00000335250  

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    Cloud-Clone Corp. Proteins for BCL2A1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    BCL2A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR002475 Bcl2-like
     IPR026298 Blc2_fam
     IPR013282 Bcl2A1
     IPR020717 Bcl2_BH1_motif_CS
     IPR020726 Bcl2_BH2_motif_CS

    Graphical View of Domain Structure for InterPro Entry Q16548

    ProtoNet protein and cluster: Q16548

    1 Blocks protein domain: IPB000712 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548
    Similarity: Belongs to the Bcl-2 family


    BCL2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B2LA1_HUMAN, Q16548
    Function: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to
    external signals and in maintaining endothelial survival during infection (By similarity)
    Induction: By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth
    factors

         Genatlas biochemistry entry for BCL2A1:
    BCL2 related gene,isolated from a fetal liver,predominantly expressed in bone marrow,involved in regulation of
    apoptosis,murine A1 homolog

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10753914
         
    BCL2A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL2A1:
     Decreased cell number 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bcl2a1a):
     immune system  integument  mortality/aging 

    BCL2A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BCL2A1: Bcl2a1atm1Orlf Bcl2a1atm1Sen

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCL2A1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74
    2Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins1.00
    3TNF Signaling
    Death Receptor Signaling0.50
    4Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway0.46
    5B cell receptor signaling pathway
    BCR signaling pathway0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for BCL2A1
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Apoptosis and survival APRIL and BAFF signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BCL2A1
        DHA Signaling

    3 GeneGo (Thomson Reuters) Pathways for BCL2A1
        Apoptosis and survival APRIL and BAFF signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    3 BioSystems Pathways for BCL2A1
        Apoptosis Modulation and Signaling
    BCR signaling pathway
    Direct p53 effectors

    1 Sino Biological Pathway for BCL2A1 
        Death Receptor Signaling


    2         Kegg Pathways  (Kegg details for BCL2A1):
        NF-kappa B signaling pathway
    Transcriptional misregulation in cancer


    BCL2A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/20 Interacting proteins for BCL2A1 (Q165482, 3 ENSP000002679534) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078123, ENSP000002932884I2D: score=4 STRING: ENSP00000293288
    BBC3Q9BXH13, ENSP000004045034I2D: score=4 STRING: ENSP00000404503
    PMAIP1Q137943, ENSP000003261194I2D: score=4 STRING: ENSP00000326119
    BADQ929343, ENSP000003091034I2D: score=3 STRING: ENSP00000309103
    BAK1Q166113, ENSP000003635914I2D: score=2 STRING: ENSP00000363591
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0042981regulation of apoptotic process ----
    GO:0043066negative regulation of apoptotic process IEA--

    BCL2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCL2A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCL2A1 (B2LA1)

    10/20 Novoseek inferred chemical compound relationships for BCL2A1 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mifepristone 67.8 9 15736964 (2), 9880517 (1), 19048455 (1), 15564339 (1) (see all 6)
    dexamethasone 63.1 13 12657604 (2), 18515658 (2), 16543270 (1), 19048455 (1) (see all 6)
    corticosterone 56.4 16 9626555 (4), 19261881 (2), 8274434 (1), 19202080 (1) (see all 5)
    dexamethasone sodium phosphate 56.3 1 17307208 (1)
    steroid 54.7 6 15358110 (1), 17116691 (1), 15736964 (1), 8190832 (1) (see all 6)
    molybdate 37.2 2 8838140 (1)
    retinoid 35 3 15774497 (1), 15016838 (1)
    clenbuterol 33.5 1 17307208 (1)
    progesterone 29 12 15736964 (2), 15774497 (1), 18215457 (1), 17571860 (1) (see all 8)
    acth 12.9 1 9629309 (1)

    Search CenterWatch for drugs/clinical trials and news about BCL2A1 / B2LA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCL2A1 gene (2 alternative transcripts): 
    NM_001114735.1  NM_004049.3  

    Unigene Cluster for BCL2A1:

    BCL2-related protein A1
    Hs.227817  [show with all ESTs]
    Unigene Representative Sequence: AK304026
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267953(uc002bfd.4 uc002bfc.4) ENST00000335661
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK304026.1 AL110097.1 AY234180.1 BC016281.1 BT007103.1 CR541937.1 CR541962.1 U27467.1 
    U29680.1 Y09397.1 

    3 DOTS entries:

    DT.111931  DT.97836197  DT.95264169 

    24/66 AceView cDNA sequences (see all 66):

    AI202978 CR541937 R29263 BC016281 U27467 BX281332 BG204033 BT007103 
    AI470744 CR541962 CD641380 CD638481 NM_004049 AI307296 Y09397 AA459491 
    AI654170 AL110097 AA256018 BE891853 CD522849 BU532682 AV716118 BG191711 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2A1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for BCL2A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL2A1 expression in normal human tissues (normalized intensities)      BCL2A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGAATAA
    BCL2A1 Expression
    About this image


    BCL2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
             heart/ventricle   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             blood vessel   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See BCL2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL2A1

    SOURCE GeneReport for Unigene cluster: Hs.227817

    UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548
    Tissue specificity: Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood,
    spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other
    tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies

        SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2A1 (see all 8): 
              NFKB Signaling Targets in human mouse rat
              Apoptosis in human mouse rat
              Atherosclerosis in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2A1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl2a1a5
    Bcl2a1d1
    B cell leukemia/lymphoma 2 related protein A1a5
    B cell leukemia/lymphoma 2 related protein A1d1
    78.49(n)1
    72.67(a)1
      9 (47.24 cM)5
    120471  NM_007536.21  NP_031562.11 
     889569205 
    chicken
    (Gallus gallus)
    Aves BCL2A11 BCL2-related protein A1 60.89(n)
    46.24(a)
      395673  NM_204866.1  NP_990197.1 


    ENSEMBL Gene Tree for BCL2A1 (if available)
    TreeFam Gene Tree for BCL2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/272 SNPs in BCL2A1 are shown (see all 272)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882140161,2
    --60291018(+) CCAAAC/TGTCAA 2 -- ds50010--------
    rs1396103081,2
    --60291020(+) AAATGG/TCAAGC 2 -- ds50010--------
    rs1497537801,2
    --60291220(+) ACACCC/TGAAAG 2 -- ds50010--------
    rs1929427791,2
    C--60291278(+) ATAATC/TAATTG 2 -- ds50010--------
    rs761898831,2
    C--60291324(+) ATTTCC/TAGCCA 2 -- ds50013Minor allele frequency- T:0.10CSA WA EA 240
    rs1846329371,2
    --60291393(+) ACATGA/GGGACA 2 -- ut310--------
    rs29575701,2
    H--60291406(+) ATTTCC/TATAAC 2 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs1478209251,2
    --60291447(+) GTTTAC/TTTAAA 2 -- ut310--------
    rs2010304011,2
    --60291498(+) AAAAAG/TTAGGC 2 -- ut310--------
    rs2006076891,2
    --60291501(+) AATTAC/GGCCGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for BCL2A1 (80253231 - 80263788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BCL2A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833065CNV Loss17160897
    nsv833066CNV Loss17160897
    nsv904435CNV Gain21882294


    Human Gene Mutation Database (HGMD): BCL2A1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601056    OMIM disorders: --

    20/35 diseases for BCL2A1 (see all 35):    About MalaCards
    somatization disorder    glucocorticoid resistance    human granulocytic anaplasmosis    stomach cancer
    urethritis    b-cell chronic lymphocytic leukemia    osteosarcoma    kaposi's sarcoma
    human t-cell leukemia virus type 1    non-hodgkin lymphoma    atopic dermatitis    hodgkin's lymphoma
    colon cancer    dermatitis    myeloma    chronic lymphocytic leukemia
    t-cell leukemia    adenoma    sarcoma    systemic lupus erythematosus


    BCL2A1 for disorders           About GeneDecksing

    10/20 Novoseek inferred disease relationships for BCL2A1 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphocytic leukemia chronic b-cell 36 2 19595676 (1), 15499630 (1)
    hypercortisolism 25.4 1 9629309 (1)
    major depression 20.5 1 18037007 (1)
    depressive disorder 18.5 3 12655328 (1), 8543464 (1)
    osteosarcoma 17.6 1 9494579 (1)
    myeloma 10.3 1 18515658 (1)
    stress disorders posttraumatic 9.28 2 14666121 (1), 18037007 (1)
    leukemia 0 3 20185581 (2), 9494579 (1)
    necrosis 0 2 17724464 (1), 8669484 (1)
    shock 0 1 8838140 (1)

    Genetic Association Database (GAD): BCL2A1
    Human Genome Epidemiology (HuGE) Navigator: BCL2A1 (16 documents)

    Export disorders for BCL2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL2A1 gene, integrated from 9 sources (see all 237):
    (articles sorted by number of sources associating them with BCL2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis. (PubMed id 17121585)1, 4, 9 Gray A....Arkwright P.D. (2006)
    2. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. (PubMed id 7478596)1, 2, 9 Choi S.S.... Shin H.-S. (1995)
    3. Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. (PubMed id 12771180)1, 3, 9 Akatsuka Y....Takahashi T. (2003)
    4. Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. (PubMed id 18812174)1, 2, 9 Herman M.D....Nordlund P. (2008)
    5. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogenei c hematopoietic cell transplantation. (PubMed id 20353833)1, 4 Larsen M.E....Vindelov L. (2010)
    6. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)
    9. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    10. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 597 HGNC: 991 AceView: BCL2A1 Ensembl:ENSG00000140379 euGenes: HUgn597
    ECgene: BCL2A1 Kegg: 597 H-InvDB: BCL2A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL2A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL2A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCL2A1 gene:
    Search GeneIP for patents involving BCL2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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