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Aliases for BCL2A1 Gene

Aliases for BCL2A1 Gene

  • BCL2-Related Protein A1 2 3
  • Hemopoietic-Specific Early Response Protein 3 4
  • Bcl-2-Like Protein 5 3 4
  • Protein BFL-1 3 4
  • Bcl2-L-5 3 4
  • BCL2L5 3 4
  • HBPA1 3 4
  • BFL1 3 4
  • GRS 3 4
  • Hematopoietic BCL2-Related Protein A1 3
  • Bcl-2-Related Protein A1 3
  • Protein GRS 4
  • ACC-1 3
  • ACC-2 3
  • ACC1 3
  • ACC2 3

External Ids for BCL2A1 Gene

Previous Symbols for BCL2A1 Gene

  • HBPA1

Summaries for BCL2A1 Gene

Entrez Gene Summary for BCL2A1 Gene

  • This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL2A1 Gene

BCL2A1 (BCL2-Related Protein A1) is a Protein Coding gene. Diseases associated with BCL2A1 include stomach cancer and glucocorticoid resistance. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Transcriptional misregulation in cancer.

UniProtKB/Swiss-Prot for BCL2A1 Gene

  • Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).

Gene Wiki entry for BCL2A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL2A1 Gene

Genomics for BCL2A1 Gene

Genomic Location for BCL2A1 Gene

Start:
79,960,889 bp from pter
End:
79,971,446 bp from pter
Size:
10,558 bases
Orientation:
Minus strand

Genomic View for BCL2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL2A1 Gene

Regulatory Elements for BCL2A1 Gene

Proteins for BCL2A1 Gene

  • Protein details for BCL2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16548-B2LA1_HUMAN
    Recommended name:
    Bcl-2-related protein A1
    Protein Accession:
    Q16548
    Secondary Accessions:
    • Q6FGZ4
    • Q6FH19
    • Q86W13
    • Q99524

    Protein attributes for BCL2A1 Gene

    Size:
    175 amino acids
    Molecular mass:
    20132 Da
    Quaternary structure:
    • Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. Interacts with BOP/C22orf29.

    Three dimensional structures from OCA and Proteopedia for BCL2A1 Gene

    Alternative splice isoforms for BCL2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL2A1 Gene

Proteomics data for BCL2A1 Gene at MOPED

Post-translational modifications for BCL2A1 Gene

No Post-translational modifications

Other Protein References for BCL2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL2A1 Gene

Domains for BCL2A1 Gene

Protein Domains for BCL2A1 Gene

UniProtKB/Swiss-Prot:

B2LA1_HUMAN
Family:
  • Belongs to the Bcl-2 family.:
    • Q16548
genes like me logo Genes that share domains with BCL2A1: view

No data available for Gene Families for BCL2A1 Gene

Function for BCL2A1 Gene

Molecular function for BCL2A1 Gene

GENATLAS Biochemistry: BCL2 related gene,isolated from a fetal liver,predominantly expressed in bone marrow,involved in regulation of apoptosis,murine A1 homolog
UniProtKB/Swiss-Prot Function: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
UniProtKB/Swiss-Prot Induction: By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors

Gene Ontology (GO) - Molecular Function for BCL2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10753914
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IBA --
GO:0051400 BH domain binding IEA --
genes like me logo Genes that share ontologies with BCL2A1: view

Phenotypes for BCL2A1 Gene

genes like me logo Genes that share phenotypes with BCL2A1: view

Animal Models for BCL2A1 Gene

MGI Knock Outs for BCL2A1:

miRNA for BCL2A1 Gene

miRTarBase miRNAs that target BCL2A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL2A1 Gene

Localization for BCL2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL2A1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL2A1 Gene COMPARTMENTS Subcellular localization image for BCL2A1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BCL2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with BCL2A1: view

Pathways for BCL2A1 Gene

genes like me logo Genes that share pathways with BCL2A1: view

Pathways by source for BCL2A1 Gene

Gene Ontology (GO) - Biological Process for BCL2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA --
GO:0042981 regulation of apoptotic process --
GO:0043066 negative regulation of apoptotic process IBA --
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IBA --
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA --
genes like me logo Genes that share ontologies with BCL2A1: view

Compounds for BCL2A1 Gene

(19) ApexBio Compounds for BCL2A1 Gene

Compound Action Cas Number
2,3-DCPE hydrochloride Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. [418788-90-6]
ABT-199 Selective Bcl-2 inhibitor [1257044-40-8]
ABT-263 (Navitoclax) orally sellecitive inhibitor of Bcl-2 family proteins [923564-51-6]
ABT-737 novel and potent inhibitor of BCL-2 family proteins [852808-04-9]
Apogossypolone (ApoG2) pan Bcl-2 inhibitor [886578-07-0]
AT-101 R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 [90141-22-3]
Bax channel blocker Potent inhibitor of Bax-mediated mitochondrial cytochrome c release. [335165-68-9]
Bax inhibitor peptide P5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-83-4]
Bax inhibitor peptide V5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-81-2]
Bax inhibitor peptide, negative control Negative control peptide for the Bax inhibitor peptides V5 and P5 [1315378-74-5]
BM-1074 potent and efficacious Bcl-2/Bcl-xL inhibitor [1391108-10-3]
Gambogic Acid activates caspases with EC50 of 0.78-1.64 uM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 [2752-65-0]
HA14-1 non-peptidic ligand of a Bcl-2 [65673-63-4]
Marinopyrrole A novel and specific Mcl-1 inhibitor [1227962-62-0]
MIM1 Inhibitor of Mcl-1
Obatoclax mesylate (GX15-070) potently inhibits BCL-2 family [803712-79-0]
Sabutoclax pan-Bcl-2 inhibitor [1228108-65-3]
TW-37 potent small-molecule inhibitor of BCL-2 [877877-35-5]
WEHI-539 high affinity (subnanomolar) and selectivity for BCL-XL [1431866-33-9]

(20) Novoseek inferred chemical compound relationships for BCL2A1 Gene

Compound -log(P) Hits PubMed IDs
mifepristone 67.8 7
dexamethasone 63.1 8
corticosterone 56.4 9
dexamethasone sodium phosphate 56.3 1
steroid 54.7 6
genes like me logo Genes that share compounds with BCL2A1: view

Transcripts for BCL2A1 Gene

mRNA/cDNA for BCL2A1 Gene

Unigene Clusters for BCL2A1 Gene

BCL2-related protein A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL2A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for BCL2A1 Gene

GeneLoc Exon Structure for
BCL2A1
ECgene alternative splicing isoforms for
BCL2A1

Expression for BCL2A1 Gene

mRNA expression in normal human tissues for BCL2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL2A1 Gene

This gene is overexpressed in Whole Blood (26.8).

SOURCE GeneReport for Unigene cluster for BCL2A1 Gene Hs.227817

mRNA Expression by UniProt/SwissProt for BCL2A1 Gene

Q16548-B2LA1_HUMAN
Tissue specificity: Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies
genes like me logo Genes that share expressions with BCL2A1: view

Orthologs for BCL2A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL2A1 36
  • 98.67 (n)
  • 98.86 (a)
BCL2A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL2A1 36
  • 81.8 (n)
  • 78.16 (a)
BCL2A1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL2A1 36
  • 77.07 (n)
  • 77.46 (a)
BCL2A1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl2a1a 16
Bcl2a1a 37
  • 72 (a)
OneToMany
Bcl2a1b 37
  • 72 (a)
OneToMany
Bcl2a1c 37
  • 56 (a)
OneToMany
Bcl2a1d 36
  • 78.49 (n)
  • 72.67 (a)
Bcl2a1d 37
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia BCL2A1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL2A1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl2a1 36
  • 81.03 (n)
  • 76.44 (a)
chicken
(Gallus gallus)
Aves BCL2A1 36
  • 60.89 (n)
  • 46.24 (a)
BCL2A1 37
  • 45 (a)
OneToOne
Species with no ortholog for BCL2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCL2A1 Gene

ENSEMBL:
Gene Tree for BCL2A1 (if available)
TreeFam:
Gene Tree for BCL2A1 (if available)

Paralogs for BCL2A1 Gene

No data available for Paralogs for BCL2A1 Gene

Variants for BCL2A1 Gene

Sequence variations from dbSNP and Humsavar for BCL2A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1138357 - 79,971,064(-) GCAGT(A/G)CGTCC missense, reference
rs1138358 - 79,971,003(-) CAAAA(G/T)GTTGC missense, reference
rs1896795 -- 79,965,994(+) TGACC(C/T)AACTG intron-variant
rs2562753 -- 79,961,645(+) TATAT(A/T)TGTAA intron-variant
rs2562754 -- 79,962,867(+) gacaa(C/T)gatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL2A1 Gene

Variant ID Type Subtype PubMed ID
nsv833065 CNV Loss 17160897
nsv833066 CNV Loss 17160897
nsv904435 CNV Gain 21882294

Relevant External Links for BCL2A1 Gene

HapMap Linkage Disequilibrium report
BCL2A1
Human Gene Mutation Database (HGMD)
BCL2A1

Disorders for BCL2A1 Gene

(20) Novoseek inferred disease relationships for BCL2A1 Gene

Disease -log(P) Hits PubMed IDs
lymphocytic leukemia chronic b-cell 36 2
hypercortisolism 25.4 1
major depression 20.5 1
depressive disorder 18.5 2
osteosarcoma 17.6 1

Relevant External Links for BCL2A1

Genetic Association Database (GAD)
BCL2A1
Human Genome Epidemiology (HuGE) Navigator
BCL2A1
genes like me logo Genes that share disorders with BCL2A1: view

No data available for UniProtKB/Swiss-Prot for BCL2A1 Gene

Publications for BCL2A1 Gene

  1. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. (PMID: 7478596) Choi S.S. … Shin H.-S. (Oncogene 1995) 3 4 23
  2. Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. (PMID: 12771180) Akatsuka Y. … Takahashi T. (J. Exp. Med. 2003) 2 3 23
  3. Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis. (PMID: 17121585) Gray A. … Arkwright P.D. (Pediatr Allergy Immunol 2006) 3 23 49
  4. Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. (PMID: 18812174) Herman M.D. … Nordlund P. (FEBS Lett. 2008) 3 4 23
  5. The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1. (PMID: 17942758) Cross A. … Edwards S.W. (Blood 2008) 3 23

Products for BCL2A1 Gene

Sources for BCL2A1 Gene

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