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BCL2A1 Gene

protein-coding GIFtS: 69

GC15M078040

BCL2-related protein A1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HBPA1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ACC-1 ^¹, ²
ACC-2 ^¹, ²
BCL2L5 ^¹, ², ³
BFL1 ^¹, ², ³
Bcl2-L-5 ^³
GRS ^¹, ², ³
HBPA1 ^², ³

Descriptions
BCL2-related protein A1 ^²
Bcl-2-like protein 5 ^³
Hemopoietic-specific early response protein ^³
Protein BFL-1 ^³
Protein GRS ^³
hematopoietic BCL2-related protein A1 ^²

External Ids
HGNC: 991¹
Entrez Gene: 597²
UniProtKB: Q16548³
Ensembl: ENSG00000140379⁷

Search outside databases for aliases for BCL2A1 gene

Previous GC identifers: GC15M076214 GC15M073410 GC15M077829 GC15M077969

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BCL2A1:

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or

homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of

cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein

encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria

and block caspase activation. This gene is a direct transcription target of NF-kappa B in response

to inflammatory mediators, and is up-regulated by different extracellular signals, such as

granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory

cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte

activation as well as cell survival. Alternatively spliced transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548

Function: Retards apoptosis induced by IL-3 deprivation. May function in the response of

hemopoietic cells to external signals and in maintaining endothelial survival during infection (By

similarity)

Gene Wiki entry for BCL2A1 (BCL2-related_protein_A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BCL2A1 gene

Entrez Gene cytogenetic band: 15q24.3 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q24.3

BCL2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M078040: (about GC identifiers)

Start:	78,040,290 bp from pter
End:	78,050,698 bp from pter
Size:	10,409 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548 (See protein sequence)

Recommended Name: Bcl-2-related protein A1

Size: 175 amino acids; 20132 Da

Subunit: Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with

BCL2L11/BIM. Interacts with BAX isoform Sigma

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

2VM6 (3D)

Secondary accessions: Q6FGZ4 Q6FH19 Q99524

REFSEQ proteins (2 alternative transcripts):

NP_001108207.1 NP_004040.1

ENSEMBL proteins:

ENSP00000335250 ENSP00000267953

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for BCL2A1 (Bcl-2 related protein A1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bcl2A1)
	Human Recombinant Proteins from Abnova (BCL2A1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	NAS	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for BCL2A1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BCL2A1
	R&D Systems Antibodies for BCL2A1 (Bcl-2 related protein A1)
	Cell Signaling Technology (CST) Antibodies for BCL2A1 (A1, Bfl-1)
	Antibodies from Abcam (Bcl2A1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BCL2A1)
	Novus Biologicals Antibodies for BCL2A1

Assays for BCL2A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q16548

ProtoNet protein and cluster: Q16548

1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548

Similarity: Belongs to the Bcl-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL2A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCL2A1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114735

Applied Biosystems Silencer® siRNAs for BCL2A1

Sigma-Aldrich siRNA and siRNA Panels for BCL2A1

Sigma-Aldrich shRNA Panels and shRNA for BCL2A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BCL2A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114735
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114735
untagged cDNA clones in CMV expression vector (see all 2): NM_001114735

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004049

UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548

Function: Retards apoptosis induced by IL-3 deprivation. May function in the response of

hemopoietic cells to external signals and in maintaining endothelial survival during infection (By

similarity)

Induction: By phorbol ester and inflammatory cytokines, such as TNF-alpha, or IL-1-beta, but not by

growth factors

Genatlas biochemistry entry for BCL2A1:

BCL2 related gene,isolated from a fetal liver,predominantly expressed in bone marrow,involved in

regulation of apoptosis,murine A1 homolog

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bcl2a1a):

immune system

life span-post-weaning/aging

skin/coat/nails

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16697956 18835031

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for BCL2A1 (Your Favorite Gene powered by Ingenuity)

B Cell Receptor Signaling
GM-CSF Signaling
Apoptosis Signaling
Docosahexaenoic Acid (DHA) Signaling

GeneDecks BCL2A1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BCL2A1

5/42 Interacting proteins for BCL2A1 (Q16548^{1, 2} ENSP00000267953³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BID	P55957¹, ENSP00000318822³	EBI-1003550, EBI-519672 STRING (score=.953)
BCL2L11	O43521¹, ENSP00000350311³	EBI-1003550, EBI-526406 STRING (score=.912)
BBC3	Q9BXH1¹, ENSP00000352999³	EBI-1003550, EBI-519884 STRING (score=.872)
NR4A1	P22736¹, ENSP00000353427³	EBI-1003550, EBI-721550 STRING (score=.752)
RELA	ENSP00000311508³	STRING (score=.981)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006916	anti-apoptosis	TAS	8605321
GO:0042981	regulation of apoptosis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for BCL2A1

Browse Small Molecules at Sigma-Aldrich

Compounds for BCL2A1 available from Tocris Bioscience
7 Novoseek chemical compound relationships for BCL2A1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	54.55	6	15358110 (1), 17116691 (1), 15736964 (1), 8190832 (1) (see all 6)
molybdate	38.87	2	8838140 (1)
progesterone	30.75	12	15736964 (2), 15774497 (1), 18215457 (1), 17571860 (1) (see all 8)
acth	14.35	1	9629309 (1)
okadaic acid	12.12	2	10347177 (1), 7570710 (1)
calcium	0.00	1	16918505 (1)
leucine	0.00	1	8834349 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL2A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCL2A1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001114735

Sigma-Aldrich siRNA and siRNA Panels for BCL2A1

Sigma-Aldrich shRNA Panels and shRNA for BCL2A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001114735 NM_004049

REFSEQ mRNAs for BCL2A1 gene (2 alternative transcripts):

NM_001114735.1 NM_004049.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001114735 NM_004049

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001114735
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001114735
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001114735

Additional cDNA sequence:

AK304026.1 AL110097.1 AY234180.1 BC016281.1 BT007103.1 CR541937.1 CR541962.1 U27467.1

U29680.1 Y09397.1

3 DOTS entries:

DT.111931 DT.97836197 DT.95264169

24/66 AceView cDNA sequences (see all 66 ):

AI202978 U27467 BC016281 CR541937 R29263 BU532682 BG191711 AI654170

AV716118 CD640333 AL110097 CD641380 AA459491 Y09397 AI470744 CD520300

BG215101 NM_004049 BG204033 AV712760 BG216703 CR541962 BX281332 CD522849

highest scoring ESTs for BCL2A1:

U27467 AA255905 AA256018 AA459263 AA837482 AI307296 AI470744 AI654170 AI738481 AJ710678

Unigene Cluster for BCL2A1:

BCL2-related protein A1

Hs.227817 [show with all ESTs]

Unigene Representative Sequence: AK304026

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2A1

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:					-

About this scheme

ECgene alternative splicing isoforms for BCL2A1

2 Ensembl transcripts including schematic representations:

ENST00000335661 ENST00000267953

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BCL2A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCL2A1

¹ / ² / ³

3 probe-sets matching BCL2A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2002_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U27467	1.00	1.00	1.00	1
205681_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004049	0.60	1.00	0.82	1
205681_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BCL2A1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAATGAATAA

SOURCE GeneReport for Unigene cluster: Hs.227817
Expression variation in blood from EXPOLDB for BCL2A1
UniProtKB/Swiss-Prot: B2LA1_HUMAN, Q16548
Tissue specificity: Seems to be restricted to the hematopoietic compartment. Expressed in
peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis,
at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic
malignancies

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for BCL2A1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCL2A1¹	--	BCL2-related protein A1	77.07(n) 77.46(a)	488770 XM_545888.2 XP_545888.2
cow (Bos taurus)	BCL2A1¹	--	BCL2-related protein A1	81.8(n) 78.16(a)	282151 NM_001037100.2 NP_001032177.1
rat (Rattus norvegicus)	Bcl2a1d¹	--	B-cell leukemia/lymphoma 2 related protein A1d	81.03(n) 76.44(a)	170929 NM_133416.1 NP_596907.1
mouse (Mus musculus)	Bcl2a1a⁵ Bcl2a1d¹	9 (50.00 cM)⁵	B-cell leukemia/lymphoma 2 related protein A1a⁵ B-cell leukemia/lymphoma 2 related protein A1d¹	78.49(n)¹ 72.67(a)¹	12047¹ NM_007536.2¹ NP_031562.1¹ AF110386⁵ AI324342⁵ (see all 11)
chicken (Gallus gallus)	BCL2A1¹	--	BCL2-related protein A1	60.89(n) 46.24(a)	395673 NM_204866.1 NP_990197.1

About this table Species with no ortholog for BCL2A1

ENSEMBL Gene Tree for BCL2A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/61 NCBI SNPs in BCL2A1 are shown (see all 61 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 33)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1138358^1,2	C,F,H,O	78050400(-)	`CAAAAT/GGTTGC`	2	K/N	mis¹		13	MN NA EU EA WA	1236
	rs1138357^1,2	C,F,H	78050461(-)	`GCAGTG/ACGTCC`	2	Y/C	mis¹ ese³		14	MN NA EA EU WA	1314
	rs3826007^1,2	C,F,H	78050272(-)	`AGACGG/ACATCA`	2	D/G	mis¹ ese³		14	EA NA EU WA	2554
	rs16971626^1,2	F,H	78051784(+)	`GAATGC/GAGACT`	1	--	ng3¹		8	NA EU EA WA	636
	rs16971627^1,2	F,H	78052331(+)	`TCCGAT/CGTGTG`	1	--	ng3¹		7	NA EU EA WA	562
	rs34080999^1,2	C,F	78050166(-)	`AAGGAG/TATTTC`	2	E/D	mis¹		5	NA EU EA WA	494
--	rs2957570^1,2	H	78040336(+)	`ATTTCC/TATAAC`	2	--	ut3¹ ese³		4	EU EA WA	420
--	rs11555732^1,2	H	78050158(-)	`TTCATA/TTTTTG`	2	Y/F	mis¹ ese³		4	EU EA WA	402
	rs8026803^1,2	A,C,F,H	78047069(+)	`ATAGGT/CGTGTG`	2	T/T	syn¹ int¹ ese³		7	EU EA WA NA	554
	rs6495460^1,2	A,C,F,H	78044410(+)	`gaggcT/Caggtc`	1	--	int¹		12	EU EA WA	1254

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HapMap Linkage Disequilibrium images for BCL2A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601056

10/20 Novoseek disease relationships for BCL2A1 gene (see all 20 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypercortisolism	27.14	1	9629309 (1)
lymphocytic leukemia chronic b-cell	25.57	1	15499630 (1)
depressive disorder	20.86	3	12655328 (1), 8543464 (1)
osteosarcoma	19.60	1	9494579 (1)
myeloma	12.09	1	18515658 (1)
stress disorders posttraumatic	12.05	2	14666121 (1), 18037007 (1)
major depression	9.84	1	18037007 (1)
necrosis	0.00	2	17724464 (1), 8669484 (1)
shock	0.00	1	8838140 (1)
colon cancer	0.00	6	9494579 (3), 17054584 (2)

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Human Gene Mutation Database: BCL2A1
Human Genome Epidemiology Navigator: BCL2A1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/195 PubMed articles for BCL2A1 gene (see all 195 ):

A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. (PubMed id 7478596)^{1, 3, 4} Choi S.S.... Shin H.-S. (1995)
Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. (PubMed id 12771180)^{1, 2, 3} Akatsuka Y....Takahashi T. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes. (PubMed id 9050999)^{3, 4} Kenny J.J....Lang J.C. (1997)
Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. (PubMed id 8605321)^{3, 4} Karsan A.... Harlan J.M. (1996)
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. (PubMed id 8589678)^{2, 3} Savitsky K.... Rotman G. (1995)
Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemia. (PubMed id 17726463)^{1, 3} Olsson A....Osorio L.M. (2007)
Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway. (PubMed id 16873269)^{1, 3} Pegman P.M....Walls D. (2006)
Oxidative stress attenuates Fas-mediated apoptosis in Jurkat T cell line through Bfl-1 induction. (PubMed id 15592513)^{1, 3} Kim H....Kim C.W. (2005)
C-terminal region of Bfl-1 induces cell death that accompanies caspase activation when fused with GFP. (PubMed id 15696550)^{1, 3} Yang W.S....Kim C.W. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 597	HGNC: 991	AceView: BCL2A1	Ensembl:ENSG00000140379	euGenes: HUgn597
ECgene: BCL2A1	H-InvDB: BCL2A1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for BCL2A1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BCL2A1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for BCL2A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BCL2A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BCL2A1		Antibodies for BCL2A1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BCL2A1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BCL2A1)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for BCL2A1 (A1, Bfl-1)

	Recombinant Proteins (Bcl2A1)
	Antibodies (Bcl2A1)

Search OriGene for BCL2A1

Tocris compounds for BCL2A1

	Drugs for BCL2A1
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Antibodies for BCL2A1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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BCL2A1 Gene at Home site.
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BCL2A1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for BCL2A1

Summaries
for BCL2A1

Genomic Location
for BCL2A1

Proteins
for BCL2A1

Protein Domains/
Families
for BCL2A1

Gene Function
for BCL2A1

Pathways & Interactions
for BCL2A1

Drugs & Compounds
for BCL2A1

Transcripts
for BCL2A1

Expression
for BCL2A1

Orthologs
for BCL2A1

Paralogs
for BCL2A1

SNPs/Variants
for BCL2A1

Disorders & Mutations
for BCL2A1

Medical News
for BCL2A1

Publications
for BCL2A1

Search for BCL2A1

Genome Databases showing BCL2A1

Other Databases showing BCL2A1

Specialized Databases showing BCL2A1

Licensable Technologies
for BCL2A1

Services
for BCL2A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BCL2A1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor BCL2A1

Summariesfor BCL2A1

Genomic Locationfor BCL2A1

Proteinsfor BCL2A1

Protein Domains/Familiesfor BCL2A1

Gene Functionfor BCL2A1

Pathways & Interactionsfor BCL2A1

Drugs & Compoundsfor BCL2A1

Transcriptsfor BCL2A1

Expression for BCL2A1

Orthologsfor BCL2A1

Paralogsfor BCL2A1

SNPs/Variantsfor BCL2A1

Disorders & Mutationsfor BCL2A1

Medical Newsfor BCL2A1

Publicationsfor BCL2A1

Search for BCL2A1

Genome Databases showing BCL2A1

Other Databases showing BCL2A1

Specialized Databases showing BCL2A1

Licensable Technologiesfor BCL2A1

Servicesfor BCL2A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BCL2A1

Summaries
for BCL2A1

Genomic Location
for BCL2A1

Proteins
for BCL2A1

Protein Domains/
Families
for BCL2A1

Gene Function
for BCL2A1

Pathways & Interactions
for BCL2A1

Drugs & Compounds
for BCL2A1

Transcripts
for BCL2A1

Expression
for BCL2A1

Orthologs
for BCL2A1

Paralogs
for BCL2A1

SNPs/Variants
for BCL2A1

Disorders & Mutations
for BCL2A1

Medical News
for BCL2A1

Publications
for BCL2A1

Licensable Technologies
for BCL2A1

Services
for BCL2A1