Aliases for BCL2A1 Gene
External Ids for BCL2A1 Gene
Previous Symbols for BCL2A1 Gene
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL2A1 Gene
BCL2A1 (BCL2-Related Protein A1) is a Protein Coding gene. Diseases associated with BCL2A1 include stomach cancer and glucocorticoid resistance. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Transcriptional misregulation in cancer.
UniProtKB/Swiss-Prot for BCL2A1 Gene
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).