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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL2 Gene

protein-coding   GIFtS: 75
GCID: GC18M060763

B-Cell CLL/Lymphoma 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 21 2     PPP1R502
Protein Phosphatase 11     Apoptosis Regulator Bcl-22
Regulatory Subunit 501     Protein Phosphatase 1, Regulatory Subunit 502
Bcl-22     

External Ids:    HGNC: 9901   Entrez Gene: 5962   Ensembl: ENSG000001717917   OMIM: 1514305   UniProtKB: P104153   

Export aliases for BCL2 gene to outside databases

Previous GC identifers: GC18M060629 GC18M058939 GC18M058941 GC18M057487


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2 Gene:
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells
such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy
chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate
splicing, differ in their C-terminal ends. (provided by RefSeq, Jul 2008)

GeneCards Summary for BCL2 Gene: 
BCL2 (B-cell CLL/lymphoma 2) is a protein-coding gene. Diseases associated with BCL2 include follicular lymphoma, and benign mammary dysplasia, and among its related super-pathways are HIV-1 Nef- Negative effector of Fas and TNF-alpha and Apoptosis and survival FAS signaling cascades. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is BAK1.

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and
neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in
a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c
from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

summary for BCL2 Gene:
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein
family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as
Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2
proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma
and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members
contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial
and other intracellular membranes.

Gene Wiki entry for BCL2 (Bcl-2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

BCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M060763:  view genomic region     (about GC identifiers)

Start:
60,790,579 bp from pter      End:
60,987,361 bp from pter
Size:
196,783 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415 (See protein sequence)
Recommended Name: Apoptosis regulator Bcl-2  
Size: 239 amino acids; 26266 Da
Subunit: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires
intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Interacts with EI24 (By
similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target
BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in
an ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via
the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the
anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the
anti-apoptotic BAX-BCL2 complex. Interacts with BOP
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass
membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
6/9 PDB 3D structures from and Proteopedia for BCL2 (see all 9):
1G5M (3D)        1GJH (3D)        1YSW (3D)        2O21 (3D)        2O22 (3D)        2O2F (3D)    
Secondary accessions: P10416 Q13842 Q16197
Alternative splicing: 2 isoforms:  P10415-1   P10415-2   

Explore the universe of human proteins at neXtProt for BCL2: NX_P10415

Explore proteomics data for BCL2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated
    phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of
    the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such
    as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates
    starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity)
  • UniProtKB: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has
    pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity
  • UniProtKB: Monoubiquitinated by PARK2, leading to increase its stability
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10415

  • BCL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000624.2  NP_000648.2  

    ENSEMBL proteins: 
     ENSP00000381185   ENSP00000329623   ENSP00000466417   ENSP00000404214  
    Reactome Protein details: P10415
    Human Recombinant Protein Products for BCL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BCL2 (Bcl-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCL2
    OriGene Protein Over-expression Lysate for BCL2
    OriGene MassSpec for BCL2 
    OriGene Custom Protein Services for BCL2
    GenScript Custom Purified and Recombinant Proteins Services for BCL2
    Novus Biologicals BCL2 Proteins
    Sino Biological Recombinant Protein for BCL2
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for BCL2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA7546744
    GO:0005737cytoplasm IDA11530860
    GO:0005739mitochondrion IDA7896880
    GO:0005741mitochondrial outer membrane TAS--

    BCL2 for ontologies           About GeneDecksing



    BCL2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2
    R&D Systems Antibodies for BCL2 (Bcl-2)
    Cell Signaling Technology (CST) Antibodies for BCL2  (Bcl-2)
    OriGene Antibodies for BCL2
    OriGene Custom Antibody Services for BCL2
    GenScript Superior Antibodies for BCL2
    Novus Biologicals BCL2 Antibodies
    Abcam antibodies for BCL2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for BCL2
    LSBio Antibodies in human, mouse, rat for BCL2 

    Assay Products for BCL2: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for BCL2 (Bcl-2)         (see all)
    GenScript Custom Assay Services for BCL2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for BCL2 (Bcl-2)
    Enzo Life Sciences assays for BCL2
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    5/9 InterPro protein domains (see all 9):
     IPR020731 Bcl2_BH4_motif_CS
     IPR020728 Bcl2_BH3_motif_CS
     IPR003093 Bcl2_BH4
     IPR002475 Bcl2-like
     IPR026298 Blc2_fam

    Graphical View of Domain Structure for InterPro Entry P10415

    ProtoNet protein and cluster: P10415

    2 Blocks protein domains:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
    Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3
    Similarity: Belongs to the Bcl-2 family


    BCL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL2_HUMAN, P10415
    Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and
    neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in
    a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c
    from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

         Genatlas biochemistry entry for BCL2:
    inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by inhibiting the release
    of cytochrome from the mitochondrial and by protecting a wide variety of cells including B cells and neuronal
    cells,activated by nerve growth factor,mediated by the p42/p44 MAPK cascade,inhibited by phosphorylation mediated
    by microtubule-damaging drugs through JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also
    modulating CDK2 activation during thymocyte apoptosis,overexpressed in endometrial carcinoma

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IDA10620603
    GO:0005515protein binding IPI10837489
    GO:0008134transcription factor binding IEA--
    GO:0015267channel activity IDA9219694
    GO:0016248channel inhibitor activity IDA9219694
         
    BCL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL2:
     Increased gamma-H2AX phosphory 

         15/21 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Bcl2) (see all 21):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  nervous system 

    BCL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BCL2: Bcl2tm1Dlo Bcl2tm1Sjk Bcl2tm1Tsu

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCL2:
    hsa-mir-630 (MIRT005578), hsa-mir-34c-5p (MIRT003979), hsa-mir-16 (MIRT001800), hsa-let-7a (MIRT000418), hsa-mir-181d (MIRT003498), hsa-mir-29b (MIRT003290), hsa-mir-34b (MIRT000065), hsa-mir-181c (MIRT003499), hsa-mir-15b (MIRT000978), hsa-mir-20a (MIRT003011), hsa-mir-15a (MIRT000815), hsa-mir-451 (MIRT005744), hsa-mir-181a (MIRT003501), hsa-mir-204 (MIRT000192), hsa-mir-17 (MIRT003014), hsa-mir-29a (MIRT003291), hsa-mir-21 (MIRT000159), hsa-mir-29c (MIRT003289), hsa-mir-34a (MIRT002298), hsa-mir-195 (MIRT005362), hsa-mir-181b (MIRT003500), hsa-mir-192 (MIRT004844), hsa-mir-153 (MIRT000290)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2 (see all 117):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCL2
    Sirion Biotech Validated adenovirus to knockdown BCL2 in human, mouse 
                         Customized adenovirus for overexpression of BCL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BCL2 (see all 15)
    OriGene ORF clones in mouse, rat for BCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
    Sino Biological Human cDNA Clone for BCL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2
    Sirion Biotech Customized lentivirus for stable overexpression of BCL2 
                         Customized lentivirus expression plasmids for stable overexpression of BCL2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BCL2
    Search LifeMap BioReagents cell lines for BCL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCL2 About   (see all 84)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptotic Pathways Triggered By HIV10.42
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    Apoptosis through Death Receptors0.42
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    FAS pathway and Stress induction of HSP regulation0.44
    3Development HGF signaling pathway
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.35
    Neurotrophin signaling pathway0.36
    4Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    5IL-2 Signaling pathway
    IL2-mediated signaling events0.49
    IL-2 Signaling pathway0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/16 EMD Millipore Pathways for BCL2 (see all 16)
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development EPO-induced Jak-STAT pathway
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    Apoptosis and survival TNFR1 signaling pathway

    4 R&D Systems Pathways for BCL2
        IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Notch Signaling Pathways

    5/48 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCL2 (see all 48)
        FLT3 Signaling
    14-3-3 Induced Apoptosis
    IL-4 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for BCL2
        Apoptosis and Autophagy

    1 Tocris Bioscience Pathway for BCL2
        Apoptosis Pathway

    5/15 GeneGo (Thomson Reuters) Pathways for BCL2 (see all 15)
        Apoptosis and survival BAD phosphorylation
    Transcription P53 signaling pathway
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    Apoptosis and survival FAS signaling cascades

    5/30 BioSystems Pathways for BCL2 (see all 30)
        Focal Adhesion
    Apoptosis
    Apoptosis Modulation and Signaling
    Senescence and Autophagy
    DNA damage response (only ATM dependent)

    2 Sino Biological Pathways for BCL2 
        p53 Pathway
    Death Receptor Signaling

    5/10        Reactome Pathways for BCL2 (see all 10)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    The NLRP1 inflammasome
    Inflammasomes
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

    2 PharmGKB Pathways for BCL2
        Busulfan Pathway, Pharmacodynamics
    Vinka Alkaloid Pathway, Pharmacokinetics

    5/18         Kegg Pathways  (Kegg details for BCL2) (see all 18):
        NF-kappa B signaling pathway
    HIF-1 signaling pathway
    Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Apoptosis


    BCL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/163 Interacting proteins for BCL2 (P104151, 2, 3 ENSP000003296234) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53BP2Q136252, 3, ENSP000003419574MINT-7235804 MINT-7235946 MINT-7235823 MINT-7236118 MINT-7236027 MINT-7236079 MINT-7236102 MINT-7236042 MINT-7236003 MINT-7235965 MINT-7235839 MINT-7236061 MINT-7235784 I2D: score=4 STRING: ENSP00000341957
    AMBRA1Q9C0C72, 3, ENSP000003183134MINT-8182706 MINT-8182670 MINT-8182688 MINT-8182559 MINT-8182625 MINT-8174974 MINT-8182589 MINT-8182650 MINT-8182607 MINT-8182574 I2D: score=1 STRING: ENSP00000318313
    BECN1Q144571, 2, 3, ENSP000003552314EBI-77694,EBI-949378 MINT-8182780 MINT-4821014 MINT-4820784 MINT-8095220 MINT-8182706 MINT-7014531 MINT-7712827 MINT-8095201 I2D: score=4 STRING: ENSP00000355231
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=3 
    About this table

    Gene Ontology (GO): 5/140 biological process terms (GO ID links to tree view) (see all 140):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0000209protein polyubiquitination IDA16717086
    GO:0000902cell morphogenesis ----
    GO:0001101response to acid IEA--
    GO:0001503ossification IEA--

    BCL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for BCL2

    Compounds for BCL2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AT 101Downregulates Bcl-2 and Mcl-1; pro-apoptotic[90141-22-3]
    HA14-1Bcl-2 inhibitor. Induces apoptosis[65673-63-4]
    MIM1Mcl-1 inhibitor; proapoptotic--
    Bax channel blockerInhibits Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide V5Inhibitor of Bax-mediated apoptosis[579492-81-2]

    4 DrugBank Compounds for BCL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DocetaxelDocetaxel anhydrous (see all 4)114977-28-5target--15643508 15161985 15714982 15685445 17674353 15277270
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4targetinhibitor17119350 16741658 17062688 16895478 17230521
    Rasagiline-- 136236-51-6targetactivator12057839 14555244 16148027 12043833 12200198
    IbuprofenIbuprophen (see all 3)15687-27-1targetmodulator22668799

    10/126 Novoseek inferred chemical compound relationships for BCL2 gene (see all 126)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genasense 81.3 45 16584297 (3), 16564596 (3), 11751483 (2), 12393493 (1) (see all 24)
    noxa 75.3 52 19372561 (3), 17018621 (3), 16673057 (2), 19540835 (2) (see all 34)
    dutp 75.2 39 9212738 (1), 11920781 (1), 12210368 (1), 14761612 (1) (see all 38)
    adpribose 71.7 49 12490780 (2), 11328292 (1), 11896536 (1), 18767861 (1) (see all 44)
    paclitaxel 71.3 393 9716607 (8), 9699642 (7), 19671798 (6), 10097113 (6) (see all 99)
    etoposide 68.8 137 10367743 (4), 8752171 (4), 9554589 (4), 8395979 (4) (see all 86)
    doxorubicin 66.8 175 8781438 (6), 12579337 (3), 18498876 (3), 19818735 (3) (see all 96)
    oridonin 66.3 15 17260801 (3), 15008459 (2), 15703811 (2), 16638644 (1) (see all 10)
    3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 66.1 6 12144824 (1), 15033191 (1), 18471799 (1), 15749633 (1) (see all 6)
    paraffin 65.4 126 9343323 (4), 9521469 (1), 10652623 (1), 10491515 (1) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about BCL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCL2 gene (2 alternative transcripts): 
    NM_000633.2  NM_000657.2  

    Unigene Cluster for BCL2:

    B-cell CLL/lymphoma 2
    Hs.150749  [show with all ESTs]
    Unigene Representative Sequence: NM_000633
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398117(uc002liu.1) ENST00000333681(uc002lit.1) ENST00000590515
    ENST00000589955 ENST00000444484(uc002liv.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2 (see all 117):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
    OriGene RNAi products in human, mouse, rat for BCL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2
    Clone
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    OriGene clones in human, mouse for BCL2 (see all 15)
    OriGene ORF clones in mouse, rat for BCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2
    Sirion Biotech Customized lentivirus for stable overexpression of BCL2 
                         Customized lentivirus expression plasmids for stable overexpression of BCL2 
    Primer
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    OriGene qPCR primer pairs and template standards for BCL2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2

    Additional mRNA sequence: 

    AF401211.1 BC027258.1 EU287875.1 M13994.1 M13995.1 M14745.1 X06487.1 

    4 DOTS entries:

    DT.216205  DT.100749960  DT.86998979  DT.40316825 

    24/148 AceView cDNA sequences (see all 148):

    BF222234 BQ215366 BM463468 AI480094 BM996398 BQ440944 AI391699 AI261915 
    F04196 AI142026 W61100 AF401211 AU135900 BE503573 AA321638 BU195508 
    BM973833 AL703462 BU159596 CB118071 N42615 BG388287 BQ224622 BM986952 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for BCL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL2 expression in normal human tissues (normalized intensities)      BCL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGGAGA
    BCL2 Expression
    About this image


    BCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 5 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T Helper Cells Thymus
             CD19+ B Cells   
             reticulocytes   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Early Ameloblasts Dental Enamel
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Hair
             Basal Keratinocytes Embryonic Epidermis

    See BCL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL2

    SOURCE GeneReport for Unigene cluster: Hs.150749

    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
    Tissue specificity: Expressed in a variety of tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2 (see all 34): 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for BCL2
    OriGene qSTAR qPCR primer pairs in human, mouse for BCL2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl21 , 5 B cell leukemia/lymphoma 21, 5 88.98(n)1
    91.53(a)1
      1 (49.76 cM)5
    120431  NM_009741.31  NP_033871.21 
     1065381785 
    chicken
    (Gallus gallus)
    Aves BCL21 B-cell CLL/lymphoma 2 75.51(n)
    77.39(a)
      396282  NM_205339.1  NP_990670.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL26
    --
    Uncharacterized protein
    69(a)
    23(a)
    1 ↔ 1
    possible ortholog
    GL344304.1(26465-27025)
    GL343287.1(852-3936)
    zebrafish
    (Danio rerio)
    Actinopterygii BCL2 (1 of 2)6
    bcl26
    (see all 3)
    B-cell leukemia/lymphoma 2
    (see all 3)
    46(a)
    46(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    2(12979720-13007658)
    24(29060361-29151442)


    ENSEMBL Gene Tree for BCL2 (if available)
    TreeFam Gene Tree for BCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCL2 gene
    BAK12  BCL2L22  BCL2L12  
    4 SIMAP similar genes for BCL2 using alignment to 3 protein entries:     BCL2_HUMAN (see all proteins):
    bcl-2    BCL2L2-PABPN1    BCL2L2    BCL2L1

    BCL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3453/4066 SNPs in BCL2 are shown (see all 4066)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0008284
    Non-Hodgkin lymphoma4--see VAR_0008282 P S mis40--------
    VAR_0008294
    Non-Hodgkin lymphoma4--see VAR_0008292 V I mis40--------
    VAR_0008274
    ----see VAR_0008272 T S mis40--------
    rs1883577131,2
    --57557443(+) TGGGGA/GGATGC 1 -- int10--------
    rs49405701,2
    C,F--57557629(+) ATTTCA/GGGATT 1 -- int13Minor allele frequency- G:0.26WA NA EA 358
    rs729394581,2
    C,F--57557709(+) GTGAGT/AGTGAA 1 -- int12Minor allele frequency- A:0.08NA EA 240
    rs1452288511,2
    --57557742(+) CTGTAC/TAGATG 1 -- int10--------
    rs1476544151,2
    --57557778(+) ATACTA/GCTGTT 1 -- int10--------
    rs1158571541,2
    C,F--57557864(+) TAGCTC/TGTTTG 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1926420051,2
    --57557871(+) TTTGCC/TGGCCC 1 -- int10--------
    rs1854366011,2
    --57557976(+) CCTTGA/GTGTTT 1 -- int10--------
    rs1162394071,2
    F--57558006(+) CTGCCT/GGTTTC 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1496748991,2
    --57558059(+) GTGGCC/TGGCTT 1 -- int10--------
    rs80839211,2
    C,F,H--57558163(+) CTCCCC/TGCTTG 1 -- int127Minor allele frequency- T:0.20NS EA WA NA CSA 2663
    rs621001711,2
    C,F--57558164(+) TCCCTG/ACTTGA 1 -- int13Minor allele frequency- A:0.14NA WA 122
    rs1454684061,2
    --57558201(+) TGGACA/GGCTGC 1 -- int10--------
    rs1488159431,2
    --57558290(+) CTCAGA/GCTGTC 1 -- int10--------
    rs621001721,2
    C,F--57558357(+) ACCACG/AGTGGC 1 -- int14Minor allele frequency- A:0.23WA NA 124
    rs80995041,2
    C,H--57558394(+) ACTGAG/CTCCAG 1 -- int17Minor allele frequency- C:0.14NS EA WA NA 752
    rs1889112351,2
    --57558517(+) TGTTGG/TCATCA 1 -- int10--------
    rs1167640781,2
    F--57558595(+) TAAGAG/ACAAGG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1117067021,2
    C,F--57558802(+) ATTTTT/AAAACT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1453485371,2
    --57558889(+) AAAGTA/GTGCAA 1 -- int10--------
    rs1464413501,2
    --57558895(+) TGCAAA/GAGCCA 1 -- int10--------
    rs1413707471,2
    --57558981(+) GCAGCA/GTGTCC 1 -- int10--------
    rs560322431,2
    C,F--57558988(+) GTCCCG/AAGTGT 1 -- int11Minor allele frequency- A:0.07NA 120
    rs8798391,2
    C,F,A--57558994(+) AGTGTG/ATCACC 1 -- int117Minor allele frequency- A:0.37NA EA WA CSA 753
    rs49411811,2
    C,F,A--57559016(+) GATGTC/GCAGTG 1 -- int115Minor allele frequency- G:0.37NA WA CSA EA 514
    rs771873291,2
    C,F--57559075(+) GGGAGG/AGTCTG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs80887391,2
    C,F,A,H--57559149(+) TCTGCT/CCTTGA 1 -- int126Minor allele frequency- C:0.34EA NA NS WA CSA 2556
    rs1847227871,2
    --57559262(+) GGAGGC/TCAAGG 1 -- int10--------
    rs768016271,2
    C,F--57559263(+) GAGGCC/TAAGGG 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1436235221,2
    --60644721(+) CAGTGA/GGAAAC 1 -- ds50010--------
    rs1463060011,2
    --60644725(+) GGGAAA/TCATCA 1 -- ds50010--------
    rs1816711741,2
    --60644766(+) CAAAGC/GAAGTA 1 -- ds50010--------
    rs1860109881,2
    --60644776(+) AGCTGC/TTTTGG 1 -- ds50010--------
    rs1134999981,2
    C,F--60644834(+) CCTCTC/TTTTCA 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1823641371,2
    --60644878(+) GATCTC/TTGGTC 1 -- ds50010--------
    rs49878711,2
    C,H--60644992(-) AAGGAG/AACTCT 1 -- ds50015Minor allele frequency- A:0.00NS EA 592
    rs1394825041,2
    --60645060(+) GAGTAG/TGGTCC 1 -- ds50010--------
    rs1139902901,2
    F--60645077(+) TTTTAC/TTGGCT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs49878701,2
    C--60645281(-) TTAGCT/-ATAAT 1 -- ut313Minor allele frequency- -:0.01NS NA 176
    rs49878691,2
    C,F,H--60645324(-) ACTTTA/CCATGG 1 -- ut31 ese310Minor allele frequency- C:0.02NS EA NA 1166
    rs455033951,2
    C--60645339(-) AAATAC/TGGTAA 1 -- ut310--------
    rs1824336771,2
    --60645380(+) CACCTC/GTTAAA 1 -- ut310--------
    rs49878681,2
    C,F,H--60645403(-) TGGCTC/ATTTTT 1 -- ut315Minor allele frequency- A:0.02NS NA 682
    rs1488881451,2
    --60645525(+) GCAAAC/TCTTGG 1 -- ut310--------
    rs560416241,2
    C--60645644(+) AATGAG/AATGAG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs49878671,2
    C,F,H--60645666(-) CTGCCG/ATGGGC 1 -- ut31 ese36Minor allele frequency- A:0.01NS EA WA 716
    rs1426164391,2
    --60645760(+) TTGAGC/TGAGCC 1 -- ut310--------
    rs1870817131,2
    --60645809(+) GCTTGA/GTATGC 1 -- ut310--------
    rs49878661,2
    C,F,H--60645915(-) ATGCAA/GAGAAA 1 -- ut31 ese35Minor allele frequency- G:0.00NS EA 594
    rs1900117401,2
    --60646098(+) ACAGAA/TGTCCC 1 -- ut310--------
    rs49878651,2
    C,F,H--60646151(-) TAAATG/ATGCAG 1 -- ut3117Minor allele frequency- A:0.05NS EA NA WA 1804
    rs49878641,2
    C,F,H--60646328(-) ATTGGG/TGTCGA 1 -- ut31 ese316Minor allele frequency- T:0.02NS EA NA WA 2048
    rs348111861,2
    C--60646470(+) AATTT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs767211111,2
    C--60646481(+) AAAAAA/TCCCTG 1 -- ut310--------
    rs775303351,2
    C--60646482(+) AAAATC/TCCTGA 1 -- ut310--------
    rs1408752761,2
    --60646502(+) ATTGAA/GTAACA 1 -- ut310--------
    rs1830005211,2
    --60646547(+) AATGTA/GGAATT 1 -- ut310--------
    rs49878631,2
    C,H--60646671(-) GAAAGG/TCTCGA 1 -- ut31 ese35Minor allele frequency- T:0.00NS EA 596
    rs1873343131,2
    --60646677(+) CTTTCC/TTGTTT 1 -- ut310--------
    rs3743689781,2
    C--60646730(+) AGAAA-/GTCT  
            
    AAAAA
    1 -- ut310--------
    rs1426117341,2
    --60646738(+) AAAAA-/CCAGCC 1 -- ut310--------
    rs1460863501,2
    C--60646768(+) TGGAAA/TTAATT 1 -- ut310--------
    rs1931510051,2
    --60646875(+) GGTGAA/GAGCTA 1 -- ut310--------
    rs1857040131,2
    --60646894(+) TTGGGA/GTTGCC 1 -- ut310--------
    rs49878621,2
    H--60646901(-) TAATCA/GGGGCA 1 -- ut315Minor allele frequency- G:0.00NS EA 590
    rs1477773481,2
    C--60646940(+) CCTCTA/CGATTT 1 -- ut310--------
    rs1410803401,2
    C--60646941(+) CTCTCA/GATTTA 1 -- ut310--------
    rs1469678891,2
    C--60647071(+) GAGCTG/TTGGAG 1 -- ut310--------
    rs1886181981,2
    --60647146(+) ATCTTA/GAGCCT 1 -- ut310--------
    rs49878611,2
    C,F,H--60647158(-) GAAAAC/TTCTGG 1 -- ut31 ese323Minor allele frequency- T:0.04NS EA NA WA CSA 2466
    rs49878601,2
    C,H--60647181(-) TCTCCG/AAAGAT 1 -- ut31 ese35Minor allele frequency- A:0.00NS EA 594
    rs49878591,2
    C,F,H--60647251(-) CCCTCG/ACTGCA 1 -- ut31 ese326Minor allele frequency- A:0.06NS NA EA CSA WA 2870
    rs413069721,2
    --60647269(+) GGGCCA/GAGGAG 1 -- ut310--------
    rs1379804141,2
    C--60647272(+) CCGAGA/GAGGTT 1 -- ut310--------
    rs49878581,2
    C,F,H--60647388(-) CTCTGT/CATGTA 1 -- ut31 ese310Minor allele frequency- C:0.03NS EA NA WA 1282
    rs1836919311,2
    --60647568(+) CTAACA/GTGTTT 1 -- ut310--------
    rs170706801,2
    C,F--60647825(-) AGAACG/ATGGAC 1 -- ut312Minor allele frequency- A:0.00MN EA 356
    rs1483414761,2
    C--60647924(+) CAGCAC/TAGGAT 1 -- ut310--------
    rs1422659651,2
    --60648011(+) CAAAGG/TTCTGA 1 -- ut310--------
    rs49878571,2
    C,H--60648038(-) CCCGGC/TGGGCC 1 -- ut31 ese36Minor allele frequency- T:0.01NS EA 700
    rs1463793991,2
    C--60648041(+) CCGCCA/GGGGAG 1 -- ut310--------
    rs49878561,2
    C,F,H--60648088(-) CTTACG/ACTCCA 1 -- ut3124Minor allele frequency- A:0.05NS NA EA 2676
    rs1176409481,2
    C,F--60648115(+) GAAGAC/TCCTGA 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs49878551,2
    C,F,H--60648143(-) TCCGCG/AGGGGC 1 -- ut31 ese318Minor allele frequency- A:0.05NS NA EA 2138
    rs49878541,2
    C,F,H--60648220(-) TGGTGG/ATTTGA 1 -- ut3112Minor allele frequency- A:0.02NS NA WA 1224
    rs49878531,2
    C,F,A,H--60648249(-) ATGGCA/GAATGA 1 -- ut3139Minor allele frequency- G:0.21NS NA EA WA CSA 4100
    rs1887971021,2
    --60648290(+) TTTAAC/TCAAAC 1 -- ut310--------
    rs1395287311,2
    --60648345(+) AGGGAC/TGAGGA 1 -- ut310--------
    rs1427567031,2
    C--60648346(+) GGGACA/GAGGAA 1 -- ut310--------
    rs1812112891,2
    --60648416(+) TTGACA/GTGGAA 1 -- ut310--------
    rs49878521,2
    C,F,H--60648515(-) TTCTGA/GGAAGG 1 -- ut31 ese318Minor allele frequency- G:0.03NS NA EA 1922
    rs1846981691,2
    --60648523(+) GAATGC/TTTTTG 1 -- ut310--------
    rs49878511,2
    C,F,H--60648853(-) ATGGTG/AGGGAA 1 -- ut3120Minor allele frequency- A:0.03NS EA NA WA 2420
    rs1132076781,2
    --60648870(+) TTTTTA/TTAATG 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs1814950001,2
    --60648881(+) CCCCAA/GGATGT 1 -- ut310--------
    rs2021121921,2
    C--60648917(+) TGGAA-/TTTTTT 1 -- ut310--------
    rs1506537831,2
    C--60648987(+) TTCCAC/TAGACA 1 -- ut310--------
    rs1397550681,2
    C--60649073(+) CCTTGC/TTTTAA 1 -- ut310--------
    rs1499403941,2
    --60649097(+) CCAAGG/TCCACA 1 -- ut310--------
    rs49878501,2
    C,F,H--60649110(-) GGCACG/ATTGGC 1 -- ut31 ese318Minor allele frequency- A:0.05NS EA NA WA CSA 1894
    rs1874551801,2
    --60649139(+) GGGCCA/GTGGCC 1 -- ut310--------
    rs1450094921,2
    --60649160(+) CTCACA/GTTCCC 1 -- ut310--------
    rs15644831,2
    C,F,O,A,H--60649248(-) GCCACA/GACCCT 1 -- ut31 ese333Minor allele frequency- N:0.00MN NS EA NA WA 4958
    rs49878491,2
    C,F,H--60649266(-) TTCACG/TTGGAG 1 -- ut31 ese36Minor allele frequency- T:0.00NS EA WA 706
    rs37449351,2
    C,F,H--60649274(+) GAAAAC/TGGGCC 1 -- ut31 ese313Minor allele frequency- T:0.04EA NS NA 2472
    rs1445272401,2
    --60649363(+) TCAGCC/TTCCAG 1 -- ut310--------
    rs20783031,2
    H--60649387(-) CAGGGC/TAGTGT 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs49878481,2
    C,F,H--60649510(-) AGGCCG/ACCACA 1 -- ut31 ese35Minor allele frequency- A:0.01NS NA 500
    rs1161171341,2
    C,F--60649547(+) TGATGC/TGGAAG 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1411745961,2
    C--60649557(+) GTCACC/TGAAAT 1 -- ut310--------
    rs49878471,2
    C,F,H--60649615(-) CCAATA/GCTGGC 1 -- ut31 ese35Minor allele frequency- G:0.01NS EA 592
    rs10168601,2
    C,F,A,H--60649668(-) CTTAAA/GCCCTG 1 -- ut3128Minor allele frequency- T:0.00NA MN NS EA CSA WA 3124
    rs1509662141,2
    --60649722(+) CACAAC/TTGGTA 1 -- ut310--------
    rs49878461,2
    C,F,H--60649772(-) ACAGCG/AATGGG 1 -- ut31 ese320Minor allele frequency- A:0.02NS EA NA 2234
    rs49878451,2
    C,F,H--60649782(-) ACGCCG/AAAGGA 1 -- ut31 ese319Minor allele frequency- A:0.05NS NA EA 2146
    rs37449371,2
    C,F,H--60649785(+) TTCGGC/TGTGGA 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 420
    rs1918580491,2
    --60649824(+) AGTTCC/TCAACT 1 -- ut310--------
    rs49878441,2
    C,F,H--60649867(-) TTTGCA/CTATGA 1 -- ut31 ese35Minor allele frequency- C:0.00NS EA 580
    rs413019451,2
    C--60649912(+) CCCCCA/CACAGG 1 -- ut310--------
    rs1133799491,2
    C--60649931(+) CTCTGG/TTAATA 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1166167241,2
    --60650087(+) CGAATA/CTATGT 1 -- ut310--------
    rs1850164071,2
    --60650128(+) CACGAA/TGCGGT 1 -- ut310--------
    rs49878431,2
    C,F,H--60650135(-) GCCAAG/ACACCG 1 -- ut3128Minor allele frequency- A:0.15NS NA EA CSA WA 2877
    rs1400936961,2
    C--60650291(+) ATTGT-/TGTGTGT 1 -- ut310--------
    rs1902621241,2
    --60650302(+) TGTGTG/TTGTCT 1 -- ut310--------
    rs2007162831,2
    --60650430(+) TATTTG/TTTTGG 1 -- ut310--------
    rs1488110591,2
    C,F--60650565(+) GGGGCC/TGTACA 2 S G mis11Minor allele frequency- T:0.00NA 4526
    rs1995409381,2
    --60650631(+) TTAGAC/GAGAGA 1 -- int10--------
    rs49878411,2
    C,F,H--60650787(-) aagagG/Agtctc 1 -- int112Minor allele frequency- A:0.03NS EA NA WA 1536
    rs1852865471,2
    --60650796(+) TTTACA/GTGCCA 1 -- int10--------
    rs1919165931,2
    --60650937(+) CCGAGA/GAGAAA 1 -- int10--------
    rs1156794071,2
    C,F--60651037(+) TGACCG/TTCACA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs105030771,2
    C,F,H--60651039(+) ACCGTC/TACACT 1 -- int118Minor allele frequency- T:0.08NS EA NA CSA WA 1016
    rs1833013341,2
    --60651077(+) AATGTC/GTGACA 1 -- int10--------
    rs782032041,2
    C--60651080(+) GTCTGA/TCATGC 1 -- int10--------
    rs2021009121,2
    C--60651119(+) TCTTTC/TTTTTT 1 -- int10--------
    rs2004393441,2
    --60651130(+) TTTTT-/CTTAGA 1 -- int10--------
    rs1891429161,2
    --60651161(+) GCCCAA/GGCTGC 1 -- int10--------
    rs750120831,2
    C--60651299(+) TAGGGC/TCTTAC 1 -- int10--------
    rs1427942401,2
    C--60651389(+) GCATGC/TGCTTT 1 -- int10--------
    rs1143334071,2
    F--60651485(+) GAATAA/GGAGAC 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1930638671,2
    --60651497(+) TTTTAA/GCAAGT 1 -- int10--------
    rs1442262281,2
    C--60651552(+) CTCTGC/TTGATG 1 -- int10--------
    rs1824280371,2
    --60651622(+) TGGAGG/TGGCCA 1 -- int10--------
    rs1487084561,2
    --60651637(+) CGGCCA/TTGACT 1 -- int10--------
    rs19826741,2
    C,F,O,H--60651655(-) AGAGGC/TTGGCA 1 -- int124Minor allele frequency- T:0.10NS EA NA WA CSA 1030
    rs1414803541,2
    C--60651670(+) TCAAGC/GTTCTC 1 -- int10--------
    rs1508388591,2
    C--60651711(+) CTTGGG/TGGTGG 1 -- int10--------
    rs1405481311,2
    C--60651717(+) GGTGGC/TTAGAC 1 -- int10--------
    rs1867651421,2
    --60651868(+) TGTAGC/TGTGTT 1 -- int10--------
    rs1919488911,2
    --60651894(+) CTCTGG/TATGGG 1 -- int10--------
    rs769326431,2
    C,F--60651975(+) AATGAG/ATATTT 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1842028331,2
    C--60652166(+) GTTGGA/GAGGGG 1 -- int10--------
    rs1894244841,2
    --60652181(+) AACAGG/TGCACA 1 -- int10--------
    rs1931738351,2
    --60652330(+) CATTGA/GTCTTT 1 -- int10--------
    rs1850829121,2
    --60652516(+) CATACG/TTTAAA 1 -- int10--------
    rs1907699891,2
    --60652526(+) AAAATC/TCATGT 1 -- int10--------
    rs1158562821,2
    C,F--60652536(+) TTTATA/TGTGTT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1177474961,2
    C,F--60652583(+) TTTTTG/ATATAT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs729413301,2
    C,F--60652586(+) TTGTAT/CATAAA 1 -- int12Minor allele frequency- C:0.03WA NA 122
    rs1818459011,2
    --60652596(+) ATTCTC/TGTCTA 1 -- int10--------
    rs19826731,2
    C,F,A,H--60652609(-) GCAACT/GGAACA 1 -- int124Minor allele frequency- G:0.25NA EA NS CSA WA 2594
    rs1444061581,2
    C--60652647(+) CCTCAA/GTTAAC 1 -- int10--------
    rs1131897031,2
    C--60652648(+) CTCAGC/TTAACC 1 -- int10--------
    rs23326731,2
    C,F,O,A,H--60652676(+) CCAGAA/CATCAT 1 -- int130Minor allele frequency- C:0.14NA EA NS WA CSA 2738
    rs1881735201,2
    --60652771(+) TAGGGC/TGAGGG 1 -- int10--------
    rs1410913021,2
    C--60653165(+) ATCTA-/TTGTTAAA 1 -- int10--------
    rs176775691,2
    C,F,H--60653204(+) GCGAGG/CCAATA 1 -- int112Minor allele frequency- C:0.05NA NS EA 1102
    rs800764431,2
    F--60653212(+) ATAGAC/TGTACA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs803399921,2
    C,F--60653307(+) CAGGGA/GTCAGT 1 -- int15Minor allele frequency- G:0.06NA WA EA 362
    rs1154144731,2
    F--60653530(+) GCTTGA/TCATTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1478573531,2
    --60653644(+) CTGAAA/GCCATC 1 -- int10--------
    rs99665631,2
    C,F,H--60653705(+) GTTGGC/TCTGGC 1 -- int116Minor allele frequency- T:0.11NS EA NA WA CSA 790
    rs1807063981,2
    --60653800(+) CCCCCA/TCACAA 1 -- int10--------
    rs1172215181,2
    F--60653855(+) ATTACG/ATAGAA 1 -- int11Minor allele frequency- A:0.03EA 120
    rs1397485871,2
    C--60653940(+) CCATCC/GCAGGG 1 -- int10--------
    rs785413771,2
    C,F--60654002(+) TGATAT/CTTTAT 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1128972371,2
    C,F--60654200(+) CTACTC/TAACCT 1 -- int12Minor allele frequency- T:0.02NA 122
    rs1180768731,2
    F--60654301(+) CTATAG/CGAATT 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1499478751,2
    C--60654359(+) GATAAC/TACAAT 1 -- int10--------
    rs1165483911,2
    C,F--60654382(+) GTCCTT/ACTTTA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1449036611,2
    --60654408(+) TAGGGC/TTAGAG 1 -- int10--------
    rs1490199881,2
    C--60654431(+) AACCCC/GCTGGA 1 -- int10--------
    rs1421175531,2
    --60654445(+) TGGAGC/GTGGCC 1 -- int10--------
    rs1855361641,2
    --60654523(+) CTGAAA/GGCTTC 1 -- int10--------
    rs1910691111,2
    --60654688(+) GAAAAC/GCTGGG 1 -- int10--------
    rs1511675191,2
    --60654696(+) GGGTCA/GTCATG 1 -- int10--------
    rs105030781,2
    C,F,H--60654782(+) TACCCG/AACTTC 1 -- int142Minor allele frequency- A:0.25NS NA EA CSA WA 3801
    rs1146060051,2
    F--60654799(+) CACAGG/ATTCAC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1155187151,2
    C,F--60654806(+) TCACAC/TGGAAA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1406898961,2
    --60654820(+) TGGCAC/GCGGCT 1 -- int10--------
    rs1837910811,2
    --60654919(+) AGAGGA/GTCTGA 1 -- int10--------
    rs1866975151,2
    --60655076(+) CCGGGC/TCATGG 1 -- int10--------
    rs1924808001,2
    --60655277(+) ACTACA/GCCCGG 1 -- int10--------
    rs1998098401,2
    --60655452(+) GAGAA-/TTTTTT 1 -- int10--------
    rs14734351,2
    C,F,H--60655461(-) TTTTTA/TAAAAA 1 -- int113Minor allele frequency- T:0.14NS EA NA WA CSA 755
    rs170707141,2
    C,F--60655483(+) CAAGAA/GTGGAA 1 -- int14Minor allele frequency- G:0.03NA WA 260
    rs1833648751,2
    --60655568(+) TATGCA/CCAGGT 1 -- int10--------
    rs1877174861,2
    --60655569(+) ATGCCC/GAGGTA 1 -- int10--------
    rs1457765081,2
    C--60655592(+) GAGACC/TTTTTG 1 -- int10--------
    rs1384956931,2
    --60655621(+) AAAAGC/GCTTTT 1 -- int10--------
    rs1414449431,2
    C--60655656(+) CTTCCA/GGTTAT 1 -- int10--------
    rs116645921,2
    H--60655715(+) ACCTGG/AAAACA 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1123885131,2
    C,F--60655778(+) AGCATC/TAAAAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs713533791,2
    C--60655794(+) CCCTAT/CAGTTA 1 -- int13Minor allele frequency- C:0.22NA EA 242
    rs1132446771,2
    F--60655897(+) ATACAC/TGTGCG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1493479141,2
    --60656081(+) TATTTC/TAATAT 1 -- int10--------
    rs1447578441,2
    C--60656380(+) TGGGGA/GAATTT 1 -- int10--------
    rs2013878011,2
    C--60656396(-) CCAGCA/CAAGCC 1 -- int10--------
    rs1156800421,2
    F--60656438(+) CACAGT/CCTTTG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1383718171,2
    --60656503(+) GCCACC/TCTGTC 1 -- int10--------
    rs1396333831,2
    --60656753(+) CTCTTC/TTCTCA 1 -- int10--------
    rs756398531,2
    C,F--60656822(+) CTGGGC/ATGGAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1175388981,2
    F--60657083(+) TGCCTC/GCCTCA 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1426925731,2
    --60657297(+) CTTTTA/GATGAC 1 -- int10--------
    rs743545851,2
    C,F--60657393(+) GATCAT/CTGGGC 1 -- int12Minor allele frequency- C:0.15CSA WA 120
    rs1505775521,2
    --60657452(+) CTGCCC/TGTCCT 1 -- int10--------
    rs49411831,2
    C,F,A,H--60657527(+) CGTCAA/GTTGTC 1 -- int124Minor allele frequency- G:0.39NS EA NA WA CSA 2490
    rs1914815921,2
    --60657557(+) TCAATC/TGCATC 1 -- int10--------
    rs49411841,2
    C,F,H--60657574(+) TTCTGG/ACCTCA 1 -- int126Minor allele frequency- A:0.10NS EA NA WA CSA 1883
    rs606494541,2
    C,F--60657607(+) TGATGC/TGTGCT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1120881861,2
    C,F--60657826(+) TGCCCC/TGGACA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs124578411,2
    C,F,H--60657840(+) AGACCA/TCTGAG 1 -- int111Minor allele frequency- T:0.39NA WA CSA EA 374
    rs80915291,2
    C,F,H--60657853(+) TCTTCC/TGTGAC 1 -- int15Minor allele frequency- T:0.02NS EA WA 526
    rs559308181,2
    C,F--60657923(+) GGCACC/TTCCTC 1 -- int12Minor allele frequency- T:0.04WA NA 122
    rs1821562941,2
    --60657948(+) ATAAGC/TTCTCG 1 -- int10--------
    rs1883637741,2
    --60658104(+) ACTTAC/TTCCAA 1 -- int10--------
    rs1496666011,2
    --60658150(+) ACCTGC/TCCCAA 1 -- int10--------
    rs80925601,2
    C,F,H--60658289(+) ATTCAT/ACAGTA 1 -- int127Minor allele frequency- A:0.45NS EA NA WA CSA 2568
    rs1926564251,2
    --60658396(+) AAGGGC/GAGCAG 1 -- int10--------
    rs1854488221,2
    --60658419(+) AAAAAA/TGGAAA 1 -- int10--------
    rs560872881,2
    C,F--60658468(+) CTACCG/AGCAAA 1 -- int16Minor allele frequency- A:0.17WA NA EA 364
    rs1899718701,2
    --60658504(+) CTGAGA/GGCCGG 1 -- int10--------
    rs1918837711,2
    --60658571(+) TACACC/GAACTC 1 -- int10--------
    rs1467036521,2
    --60658698(+) TATAGC/TTGGAG 1 -- int10--------
    rs1169796551,2
    F--60658930(+) AATCAA/GATCTG 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1847456711,2
    --60659067(+) ACTTTA/CTCCAA 1 -- int10--------
    rs126058581,2
    C,F,H--60659077(+) aatccC/Ataggt 1 -- int15Minor allele frequency- A:0.00NS EA NA 418
    rs1402812491,2
    C--60659082(+) CTAGGG/TTGAGC 1 -- int10--------
    rs1891978011,2
    --60659125(+) ATTATA/TCGAAG 1 -- int10--------
    rs118722971,2
    C,F,H--60659168(+) aactaT/Ctagca 1 -- int15Minor allele frequency- C:0.00NS EA NA 414
    rs1119335181,2
    C--60659235(+) TCATAT/CGTTAG 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs729413461,2
    C,F--60659319(+) AATAGA/GTAATA 1 -- int11Minor allele frequency- G:0.12NA 120
    rs1858682501,2
    --60659459(+) AGGACA/GCAGAG 1 -- int10--------
    rs118744951,2
    C,H--60659527(+) CACAGG/ATGCTT 1 -- int15Minor allele frequency- A:0.00NS EA NA 418
    rs1899938801,2
    --60659558(+) AGCATC/TTTCCA 1 -- int10--------
    rs8999651,2
    C,F,H--60659607(-) AAACAC/TAGCAG 1 -- int130Minor allele frequency- T:0.13NS EA NA WA CSA 2308
    rs118724031,2
    C,F,A,H--60659642(+) ACAAGG/TGCTGC 1 -- int127Minor allele frequency- N:0.00EA NA NS WA CSA 2564
    rs729413481,2
    C,F--60659696(+) CAGCAT/CTGGTG 1 -- int11Minor allele frequency- C:0.11NA 120
    rs1143915271,2
    F--60659726(+) GAGACG/AACCAG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs8999641,2
    C,F,O,H--60659766(-) CTCTAT/CGTTTG 1 -- int117Minor allele frequency- C:0.07NS EA NA WA CSA 794
    rs1812525251,2
    --60659775(+) AGACCA/TCTGGG 1 -- int10--------
    rs7208491,2
    F,H--60660049(-) CGGCCA/GCCACT 1 -- int14Minor allele frequency- G:0.00NS EA 412
    rs1440244451,2
    --60660132(+) TCCCCC/TCTTAT 1 -- int10--------
    rs1159864181,2
    F--60660146(+) CGGCTC/TGGCAG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs49878401,2
    C--60660262(-) GGTGCG/AGGAGG 1 -- int1 trp31Minor allele frequency- A:0.01NS 176
    rs49878391,2
    C,F,H--60660345(-) CCTTCA/GGTTAT 1 -- int128Minor allele frequency- G:0.19NS NA EA 3040
    rs1178268741,2
    F--60660388(+) AGGCAC/TGGGAG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs49878381,2
    C,F--60660395(-) TCTCAC/TGCTCC 1 -- int15Minor allele frequency- T:0.03NS NA WA 432
    rs1491790771,2
    --60660422(+) TTCCTC/TCAGGC 1 -- int10--------
    rs1433988741,2
    --60660667(+) GGTGTA/GTTCTG 1 -- int10--------
    rs1915986411,2
    --60660691(+) GCTAAA/GAATGC 1 -- int10--------
    rs1814874801,2
    --60660693(+) TAAGAA/TTGCAA 1 -- int10--------
    rs49878371,2
    C,H--60660745(-) TTTGGG/TCTTCT 1 -- int15Minor allele frequency- T:0.00NS EA 590
    rs49878351,2
    C,F,H--60660811(-) GGCATA/GAGCCA 1 -- int119Minor allele frequency- G:0.21NS EA NA WA 1548
    rs1483757491,2
    --60660824(+) GGGCCA/CGGGCA 1 -- int10--------
    rs49878341,2
    C,F,H--60660849(-) CAGGTG/AGTTGG 1 -- int112Minor allele frequency- A:0.19NS EA NA WA 938
    rs713401461,2
    C--60660849(+) CCAACCACCTG/-
            
    CTAAT
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs49878331,2
    C--60660850(-) CATTAGCAGGT/-
            
    GGTTG
    1 -- int11Minor allele frequency- -:0.01NS 164
    rs49878321,2
    C,F,H--60660873(-) AGCTCC/TGGCTG 1 -- int16Minor allele frequency- T:0.02NS EA WA 682
    rs49878311,2
    C,F,H--60660968(-) CTTGGC/TTCTGT 1 -- int121Minor allele frequency- T:0.47NS EA NA WA CSA 1319
    rs49878301,2
    C,F--60660972(-) GGAACT/CTGGCT 1 -- int12Minor allele frequency- C:0.07NS NA 290
    rs49878291,2
    C,F,H--60661010(-) GGTGCC/TCTGCA 1 -- int117Minor allele frequency- T:0.12NS EA NA WA 1610
    rs1864995001,2
    --60661014(+) GGGCAC/TCTGTG 1 -- int10--------
    rs1909407351,2
    --60661080(+) CTTCTA/GAAATA 1 -- int10--------
    rs1824104391,2
    --60661132(+) TTAATA/CGTTAT 1 -- int10--------
    rs1875647311,2
    C--60661198(+) GTATCC/TATATG 1 -- int10--------
    rs15316971,2
    C,F,O,A,H--60661202(-) AGGTCA/TTATAG 1 -- int145Minor allele frequency- T:0.29NA EA NS CSA WA 4437
    rs1916076371,2
    --60661218(+) TCTCAC/TCTTCA 1 -- int10--------
    rs1404599661,2
    --60661341(+) GTGGCA/TTCCAT 1 -- int10--------
    rs1503981981,2
    C--60661409(+) CCATTC/TGCCCA 1 -- int10--------
    rs1830073361,2
    --60661413(+) TTGCCC/TAGCAG 1 -- int10--------
    rs49878281,2
    C,F,H--60661468(-) GGTGTG/ACCTTA 1 -- int126Minor allele frequency- A:0.16NS EA NA WA 3068
    rs49878271,2
    C,F,H--60661494(-) TAGGCC/ACTTTC 1 -- int1 trp321Minor allele frequency- A:0.19NS EA NA WA 1718
    rs563139831,2
    C,F--60661549(+) TAAAAC/TGAAGT 1 -- int11Minor allele frequency- T:0.12NA 120
    rs621001761,2
    C,F--60661645(+) CCCTCT/CCTTGT 1 -- int16Minor allele frequency- C:0.21WA NA EA 364
    rs1382597551,2
    --60661711(+) AACTTA/TACACT 1 -- int10--------
    rs798306201,2
    F--60661727(+) GATATT/CGTGTT 1 -- int11Minor allele frequency- C:0.07WA 118
    rs621001771,2
    C,F--60661788(+) AAAAAC/TGTAAG 1 -- int16Minor allele frequency- T:0.21WA NA EA 364
    rs588074191,2
    C--60661916(+) CAAATC/TGAAAC 1 -- int10--------
    rs99629631,2
    C,F--60662041(+) AACTGG/TTGCAG 1 -- int110Minor allele frequency- T:0.25NA CSA WA EA 370
    rs1472591081,2
    --60662094(+) CAGAGA/TCACCA 1 -- int10--------
    rs1381211211,2
    --60662095(+) AGAGTA/CACCAC 1 -- int10--------
    rs581589291,2
    C,F--60662150(+) TTGCAC/TGTTCA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1114704301,2
    C,F--60662158(+) TCACAC/AGAAAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs2