Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL2 Gene

protein-coding   GIFtS: 74
GCID: GC18M060763

B-cell CLL/lymphoma 2
 Explore 371 diseases affiliated with
BCL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BCL2    

Aliases
for BCL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
B-Cell CLL/Lymphoma 21 2
Bcl-21 2
PPP1R501 2
Apoptosis Regulator Bcl-22
Protein Phosphatase 1, Regulatory Subunit 502

External Ids:    HGNC: 9901   Entrez Gene: 5962   Ensembl: ENSG000001717917   OMIM: 1514305   UniProtKB: P104153   

Export aliases for BCL2 gene to outside databases

Previous GC identifers: GC18M060629 GC18M058939 GC18M058941 GC18M057487


Summaries
for BCL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BCL2:
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such
as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus,
is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in
their C-terminal ends. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural
cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback
loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the
mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

summary for BCL2:
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein
family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as
Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2
proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma
and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members
contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial
and other intracellular membranes.

Gene Wiki entry for BCL2 (Bcl-2)


Genomic Views
for BCL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

BCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M060763:  view genomic region     (about GC identifiers)

Start:
 60,790,579 bp from pter      End:
 60,987,361 bp from pter
Size:
 196,783 bases      Orientation:
 minus strand

Proteins
for BCL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415 (See protein sequence)
Recommended Name: Apoptosis regulator Bcl-2  
Size: 239 amino acids; 26266 Da
Subunit: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires
intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Interacts with EI24 (By
similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2
to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an
ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via the BH4
domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic
activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2
complex. Interacts with BOP
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass
membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
6/9 PDB 3D structures from and Proteopedia for BCL2 (see all 9):
1G5M (3D)        1GJH (3D)        1YSW (3D)        2O21 (3D)        2O22 (3D)        2O2F (3D)    
Secondary accessions: P10416 Q13842 Q16197
Alternative splicing: 2 isoforms:  P10415-1   P10415-2   

Explore the universe of human proteins at neXtProt for BCL2: NX_P10415

Post-translational modifications:

  • Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation
    • on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In
    the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and
    stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates
    starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic
    • activity, causes the release of cytochrome c into the cytosol promoting further caspase activity1
  • Monoubiquitinated by PARK2, leading to increase its stability1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P10415

    • BCL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000624.2  NP_000648.2  

    ENSEMBL proteins: 
     ENSP00000381185   ENSP00000329623   ENSP00000466417   ENSP00000404214  
    Reactome Protein details: P10415
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BCL2 (Bcl-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: BCL2
    OriGene Protein Over-expression Lysate (see all 2): BCL2
    OriGene Custom Protein Services for BCL2 
    GenScript Custom Purified and Recombinant Proteins Services for BCL2
    Novus Biologicals BCL2 Proteins
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for BCL2
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005624membrane fraction ----
    GO:0005634nucleus IDA7896880
    GO:0005737cytoplasm IDA7546744
    GO:0005739mitochondrion IDA7896880


    BCL2 for ontologies           About GeneDecksing



    BCL2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2
    R&D Systems Antibodies for BCL2 (Bcl-2)
    Cell Signaling Technology (CST) Antibodies for BCL2  (Bcl-2)
    OriGene Antibodies (see all 4): BCL2
    OriGene Custom Antibody Services for BCL2 
    GenScript Superior Antibodies for BCL2
    Novus Biologicals BCL2 Antibodies
    Abcam antibodies for BCL2 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for BCL2

    Assay Products for BCL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for BCL2 (Bcl-2)         (see all)
    GenScript Custom Assay Services for BCL2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for BCL2 (Bcl-2)
    Enzo Life Sciences assays for BCL2
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for BCL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BCL2 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR020731 Bcl2_BH4_motif_CS
     IPR020728 Bcl2_BH3_motif_CS
     IPR003093 Bcl2_BH4
     IPR002475 Bcl2-like
     IPR026298 Blc2_fam

    Graphical View of Domain Structure for InterPro Entry P10415

    ProtoNet protein and cluster: P10415

    2 Blocks protein families:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
    Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3
    Similarity: Belongs to the Bcl-2 family


    Function
    for BCL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
    Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural
    cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback
    loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the
    mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

         Genatlas biochemistry entry for BCL2:
    inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by inhibiting the release of
    cytochrome from the mitochondrial and by protecting a wide variety of cells including B cells and neuronal
    cells,activated by nerve growth factor,mediated by the p42/p44 MAPK cascade,inhibited by phosphorylation mediated by
    microtubule-damaging drugs through JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also modulating
    CDK2 activation during thymocyte apoptosis,overexpressed in endometrial carcinoma

    miRNA
    Products:            		miRTarBase miRNAs that target BCL2:
    hsa-mir-630 (MIRT005578), hsa-mir-34c-5p (MIRT003979), hsa-mir-16 (MIRT001800), hsa-let-7a (MIRT000418), hsa-mir-181d (MIRT003498), hsa-mir-29b (MIRT003290), hsa-mir-34b (MIRT000065), hsa-mir-181c (MIRT003499), hsa-mir-15b (MIRT000978), hsa-mir-20a (MIRT003011), hsa-mir-15a (MIRT000815), hsa-mir-451 (MIRT005744), hsa-mir-181a (MIRT003501), hsa-mir-204 (MIRT000192), hsa-mir-17 (MIRT003014), hsa-mir-29a (MIRT003291), hsa-mir-21 (MIRT000159), hsa-mir-29c (MIRT003289), hsa-mir-34a (MIRT002298), hsa-mir-195 (MIRT005362), hsa-mir-181b (MIRT003500), hsa-mir-192 (MIRT004844), hsa-mir-153 (MIRT000290)

    OriGene 3'-UTR Clone (see all 2): BCL2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2 (see all 117):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2 (see all 7)
    OriGene shRNA RFP: BCL2
    OriGene siRNA: BCL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BCL2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
    Sino Biological Human cDNA Clone for BCL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BCL2
    Search LifeMap BioReagents cell lines for BCL2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IDA10620603
    GO:0005515protein binding IPI--
    GO:0008134transcription factor binding IEA--
    GO:0015267channel activity IDA9219694
    GO:0019903protein phosphatase binding ----


    BCL2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BCL2:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for BCL2: Bcl2tm1Dlo Bcl2tm1Sjk Bcl2tm1Tsu
         15/21 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Bcl2) (see all 21):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  nervous system 

    BCL2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BCL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/74 super-pathways (see all 74) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2Development HGF signaling pathway
    		Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR10.24
    		Neurotrophin signaling pathway0.20
    		Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.24
    		Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR20.15
    		Apoptosis and survival_Role of CDK5 in neuronal death and survival0.24
    		Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR20.15
    		Apoptosis and survival Role of CDK5 in neuronal death and survival0.24
    3BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members1.00
    		Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins0.24
    		Activation of BH3-only proteins0.30
    		Intrinsic Pathway for Apoptosis0.23
    		Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins0.24
    		Activation of BAD and translocation to mitochondria 0.15
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    5TWEAK Pathway
    		HIV-1 Nef- Negative effector of Fas and TNF-alpha0.42
    		Apoptotic Pathways Triggered By HIV10.37
    		Apoptosis and survival_TNFR1 signaling pathway0.40
    		Apoptosis through Death Receptors0.32
    		Apoptosis and survival TNFR1 signaling pathway0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/16 EMD Millipore Pathways for BCL2 (see all 16)
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development EPO-induced Jak-STAT pathway
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    Apoptosis and survival TNFR1 signaling pathway

    3 R&D Systems Pathways for BCL2
        IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/48 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCL2 (see all 48)
        FLT3 Signaling
    14-3-3 Induced Apoptosis
    IL-4 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for BCL2
        Apoptosis and Autophagy

    1 Tocris Bioscience Pathway for BCL2
        Apoptosis Pathway

    5/15 GeneGo (Thomson Reuters) Pathways for BCL2 (see all 15)
        Apoptosis and survival BAD phosphorylation
    Transcription P53 signaling pathway
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    Apoptosis and survival FAS signaling cascades

    5/30 BioSystems Pathways for BCL2 (see all 30) 
        FAS pathway and Stress induction of HSP regulation
    DNA damage response (only ATM dependent)
    Focal Adhesion
    Senescence and Autophagy
    Integrated Breast Cancer Pathway

    5/10        Reactome Pathways for BCL2 (see all 10)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    The NLRP1 inflammasome
    Inflammasomes
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

    2 PharmGKB Pathways for BCL2
        Busulfan Pathway, Pharmacodynamics
    Vinka Alkaloid Pathway, Pharmacokinetics

    5/12         Kegg Pathways  (Kegg details for BCL2) (see all 12):
        Protein processing in endoplasmic reticulum
    Apoptosis
    Focal adhesion
    Neurotrophin signaling pathway
    Cholinergic synapse


    BCL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/155 Interacting proteins for BCL2 (P104151, 2, 3 ENSP000003296234) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53BP2Q136252, 3, ENSP000003419574MINT-7235804 MINT-7235946 MINT-7235823 MINT-7236118 MINT-7236027 MINT-7236079 MINT-7236102 MINT-7236042 MINT-7236003 MINT-7235965 MINT-7235839 MINT-7236061 MINT-7235784 I2D: score=4 STRING: ENSP00000341957
    AMBRA1Q9C0C72, 3, ENSP000003183134MINT-8182706 MINT-8182670 MINT-8182688 MINT-8182559 MINT-8182625 MINT-8174974 MINT-8182589 MINT-8182650 MINT-8182607 MINT-8182574 I2D: score=1 STRING: ENSP00000318313
    BECN1Q144571, 2, 3, ENSP000003552314EBI-77694,EBI-949378 MINT-8182780 MINT-4821014 MINT-4820784 MINT-8095220 MINT-8182706 MINT-7014531 MINT-7712827 MINT-8095201 I2D: score=4 STRING: ENSP00000355231
    TP53P046371, 2, 3, ENSP000002693054EBI-77694,EBI-366083 MINT-7291988 MINT-7292025 MINT-7291975 I2D: score=2 STRING: ENSP00000269305
    BCL2L11O435211, 2, 3EBI-77694,EBI-1002160 MINT-6629252 MINT-4980319 I2D: score=12 
    About this table

    Gene Ontology (GO): 5/154 biological process terms (GO ID links to tree view) (see all 154):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0000209protein polyubiquitination IDA16717086
    GO:0000902cell morphogenesis ----
    GO:0001101response to acid IEA--
    GO:0001503ossification IEA--


    BCL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BCL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for BCL2

    Compounds for BCL2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    2,3-DCPE hydrochloride Selectively induces cancer cell apoptosis[418788-90-6]
    GossypolPro-apoptotic; downregulates Bcl-2 and Bcl-XL[303-45-7]
    HA14-1Bcl-2 inhibitor. Induces apoptosis[65673-63-4]

    3 DrugBank Compounds for BCL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DocetaxelDocetaxel anhydrous (see all 3)114977-28-5target--15643508 15161985 15714982 15685445 17674353 15277270
    Paclitaxel7-epi-Paclitaxel (see all 5)33069-62-4targetinhibitor17119350 16741658 17062688 16895478 17230521
    Rasagiline-- 136236-51-6targetactivator12057839 14555244 16148027 12043833 12200198

    10/126 Novoseek chemical compound relationships for BCL2 gene (see all 126)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genasense 81.3 45 16584297 (3), 16564596 (3), 11751483 (2), 12393493 (1) (see all 24)
    noxa 75.3 52 19372561 (3), 17018621 (3), 16673057 (2), 19540835 (2) (see all 34)
    dutp 75.2 39 9212738 (1), 11920781 (1), 12210368 (1), 14761612 (1) (see all 38)
    adpribose 71.7 49 12490780 (2), 11328292 (1), 11896536 (1), 18767861 (1) (see all 44)
    paclitaxel 71.3 393 9716607 (8), 9699642 (7), 19671798 (6), 10097113 (6) (see all 99)
    etoposide 68.8 137 10367743 (4), 8752171 (4), 9554589 (4), 8395979 (4) (see all 86)
    doxorubicin 66.8 175 8781438 (6), 12579337 (3), 18498876 (3), 19818735 (3) (see all 96)
    oridonin 66.3 15 17260801 (3), 15008459 (2), 15703811 (2), 16638644 (1) (see all 10)
    3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 66.1 6 12144824 (1), 15033191 (1), 18471799 (1), 15749633 (1) (see all 6)
    paraffin 65.4 126 9343323 (4), 9521469 (1), 10652623 (1), 10491515 (1) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about BCL2 

    Transcripts
    for BCL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BCL2 gene (2 alternative transcripts): 
    NM_000633.2  NM_000657.2  

    Unigene Cluster for BCL2:

    B-cell CLL/lymphoma 2
    Hs.150749  [show with all ESTs]
    Unigene Representative Sequence: NM_000633
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398117(uc002liu.1) ENST00000333681(uc002lit.1) ENST00000590515
    ENST00000589955 ENST00000444484(uc002liv.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): BCL2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2 (see all 117):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2 (see all 7)
    OriGene shRNA RFP: BCL2
    OriGene siRNA: BCL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2

    Additional cDNA sequence: 

    AF401211.1 BC027258.1 EU287875.1 M13994.1 M13995.1 M14745.1 X06487.1 

    4 DOTS entries:

    DT.216205  DT.100749960  DT.86998979  DT.40316825 

    24/148 AceView cDNA sequences (see all 148):

    AA321638 F04196 BQ224622 AF401211 BG503428 BF222234 BM986952 BM973833 
    AI261915 W61100 AI391699 BE503573 F07940 BE550816 AL703462 BM463468 
    AI627828 N42615 BC027258 BM996398 N29770 AI480094 CB118071 AI142026 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for BCL2

    Expression
    for BCL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGTGGAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BCL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    White adipocyte-like cells (Differentiation of w...)
    Brown adipocyte-like cells (Differentiation of w...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BCL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL2

    SOURCE GeneReport for Unigene cluster: Hs.150749

    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
    Tissue specificity: Expressed in a variety of tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2 (see all 34): 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

    Orthologs
    for BCL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BCL21 B-cell CLL/lymphoma 2 75.51(n)
    77.39(a)    		   396282  NM_205339.1  NP_990670.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BCL26
    		 --
    		 70(a)
    		 1 ↔ 1
    		 GL344304.1(26465-27025)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-217f4.36
    CU695001.16
    		 --
    		 49(a)
    46(a)
    		 1 ↔ many
    1 ↔ many
    		 2(12979720-13007658)
    24(29060361-29151442)


    ENSEMBL Gene Tree for BCL2 (if available)
    TreeFam Gene Tree for BCL2 (if available) 

    Paralogs
    for BCL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCL2 gene
    BAK12  BCL2L22  BCL2L12  BAX2  
    4 SIMAP similar genes for BCL2 using alignment to 3 protein entries:     BCL2_HUMAN     A0N771_HUMAN     C9JHD5_HUMAN(see first protein):
    bcl-2    BCL2L2-PABPN1    BCL2L2    BCL2L1

    BCL2 for paralogs           About GeneDecksing



    Genomic Variants
    for BCL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3487 NCBI SNPs in BCL2 are shown (see all 3487)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs352753571,2
    		C--57648853(+) CTAAT-/TTAG  
                TTGTT     		1 -- int10--------
    rs1883577131,2
    		--60765382(+) TGGGGA/GGATGC 1 -- int10--------
    rs49405701,2
    		C,F,--60765568(+) ATTTCA/GGGATT 1 -- int13Minor allele frequency- G:0.26WA NA EA 358
    rs729394581,2
    		C,F,--60765648(+) GTGAGT/AGTGAA 1 -- int12Minor allele frequency- A:0.08NA EA 240
    rs1452288511,2
    		--60765681(+) CTGTAC/TAGATG 1 -- int10--------
    rs1476544151,2
    		--60765717(+) ATACTA/GCTGTT 1 -- int10--------
    rs1158571541,2
    		F,--60765803(+) TAGCTC/TGTTTG 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1926420051,2
    		--60765810(+) TTTGCC/TGGCCC 1 -- int10--------
    rs1854366011,2
    		--60765915(+) CCTTGA/GTGTTT 1 -- int10--------
    rs1162394071,2
    		--60765945(+) CTGCCT/GGTTTC 1 -- int11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for BCL2 (60790579 - 60987361 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for BCL2
         1 CNV: 102690
         1 Indel: 60265
    Human Gene Mutation Database (HGMD): BCL2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL2

    Disorders / Diseases
    for BCL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BCL2 for disorders           About GeneDecksing

    OMIM gene information: 151430    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
  • Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation
    • t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the
    chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide
    transitions

    20/371 diseases for BCL2 (see all 371):    About MalaCards
    lymphoma, small cleaved-cell, follicular    follicular lymphoma    spinal cord injury    leukemia/lymphoma, b-cell, 2
    estrogen-receptor positive breast cancer    li-fraumeni syndrome    pelviureteric junction obstruction    malignant peripheral nerve sheath tumor
    lymphoepithelioma-like carcinoma    adenosine deaminase deficiency    b-cell non-hodgkin lymphoma    natural killer cell leukemia
    spinal muscular atrophy    fuchs' endothelial dystrophy    serous cystadenocarcinoma    squamous cell carcinoma
    diffuse large b-cell lymphoma    human t-cell leukemia virus type 1    hypersensitivity reaction type ii disease    non-hodgkin lymphoma

    6 diseases from the University of Copenhagen DISEASES database for BCL2:
    Lymphoma     Leukemia     Carcinoma     Breast cancer
    Vascular disease     Lung cancer

    10/93 Novoseek disease relationships for BCL2 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma follicular 87.1 381 18945749 (7), 2223650 (5), 18925696 (5), 9349233 (4) (see all 99)
    tumors 83.8 3055 2214188 (7), 9002964 (7), 17295204 (6), 15667975 (6) (see all 99)
    lymphoma b-cell 82.4 319 18925696 (5), 20459572 (4), 8639245 (3), 9242549 (3) (see all 99)
    lymphoma 78.3 595 16373664 (5), 1890741 (5), 11431360 (5), 8371594 (5) (see all 99)
    cancer 77.8 713 9416483 (5), 11728179 (5), 9000560 (4), 16531274 (4) (see all 99)
    leukemia 74.3 316 18422996 (5), 10456672 (4), 10023011 (4), 20350424 (4) (see all 99)
    breast cancer 70.7 671 20068093 (5), 19762066 (5), 11235572 (5), 17288732 (5) (see all 99)
    necrosis 69.1 225 10064615 (4), 10464427 (3), 19331832 (3), 10754212 (2) (see all 99)
    lymphoma non-hodgkins 68.1 150 15503680 (3), 11380403 (3), 9113013 (3), 1747446 (2) (see all 99)
    lymphocytic leukemia chronic b-cell 67.8 31 8104532 (2), 9373241 (1), 17132110 (1), 8260892 (1) (see all 27)

    Genatlas disease: BCL2
    non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation
    t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated lymphoid tissue),with
    translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between BCL2 and DCC

    Genetic Association Database (GAD): BCL2
    Human Genome Epidemiology (HuGE) Navigator: BCL2 (73 documents)
    Tumor Gene Database (TGDB): BCL2

    Export disorders for BCL2 gene to outside databases

    Publications
    for BCL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL2 gene, integrated from 9 sources (see all 7125):
    (articles sorted by number of sources associating them with BCL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. (PubMed id 15849194)1, 2, 9 Jin S....Field J. (2005)
    2. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. (PubMed id 10567572)1, 2, 9 Yamamoto K.... Korsmeyer S.J. (1999)
    3. Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. (PubMed id 16148027)1, 7, 9 Bar-Am O....Youdim M.B. (2005)
    4. Phosphorylation of Bcl2 and regulation of apoptosis. (PubMed id 11368354)1, 2, 9 Ruvolo P.P.... May W.S. (2001)
    5. Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (PubMed id 11325850)1, 4, 9 Tsukasaki K....Koeffler H.P. (2001)
    6. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. (PubMed id 1339299)1, 2, 9 Tanaka S.... Reed J.C. (1992)
    7. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. (PubMed id 2250705)1, 2, 9 Hockenbery D.... Korsmeyer S.J. (1990)
    8. Parkin mono-ubiquitinates Bcl-2 and regulates autopha gy. (PubMed id 20889974)1, 2 Chen D....Wang G. (2010)
    9. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (PubMed id 19228691)1, 2 Eliseev R.A....Gunter T.E. (2009)
    10. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (PubMed id 18570871)1, 2 Wei Y....Levine B. (2008)

    External Searches for BCL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BCL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 596 HGNC: 990 AceView: BCL2 Ensembl:ENSG00000171791 euGenes: HUgn596
    ECgene: BCL2 Kegg: 596 H-InvDB: BCL2

    Other Databases showing BCL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BCL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bcl2/
    Wikipedia http://en.wikipedia.org/wiki/Bcl-2

    Intellectual Property
    for BCL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BCL2 gene:
    Search GeneIP for patents involving BCL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BCL2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2
     EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for BCL2 (Bcl-2)   Browse Cell Culture Products  
     ELISAs for BCL2 (Bcl-2)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for BCL2 (Bcl-2)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for BCL2 (Bcl-2)  
     OriGene Antibodies for BCL2   OriGene shRNA RFP for BCL2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2  
     OriGene Protein Over-expression Lysate for BCL2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BCL2   OriGene 3'-UTR Clone for BCL2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for BCL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCL2   OriGene Custom Protein Services for BCL2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCL2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2
     GenScript Custom Purified and Recombinant Proteins Services for BCL2 GenScript cDNA clones with any tag delivered in your preferred vector for BCL2
     GenScript Custom Assay Services for BCL2 GenScript Superior Antibodies for BCL2
     GenScript Custom overexpressing Cell Line Services for BCL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for BCL2  (Bcl-2)

     Regulatory tfbs in BCL2 promoter
     Search Chromatin IP Primers for BCL2
     RT2 qPCR Primer Assay in human, mouse, rat BCL2
     GNC Network for BCL2
     SABiosciences PCR Arrays including human, mouse, rat BCL2
     Tocris compounds for BCL2
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for BCL2
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Assays/Drugs for BCL2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BCL2 antibodies
     BCL2 proteins
     Antibodies for BCL2
     See all of Abcam's Antibodies, Kits and Proteins for BCL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for BCL2




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for BCL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for BCL2
     SwitchGear Promoter luciferase reporter plasmids for BCL2
     ThermoFisher Antibody for BCL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      BCL2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4