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BCL2 Gene

protein-coding   GIFtS: 73
GCID: GC18M060763

B-Cell CLL/Lymphoma 2

  See BCL2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B-Cell CLL/Lymphoma 21 2     PPP1R502
Protein Phosphatase 11     Apoptosis Regulator Bcl-22
Regulatory Subunit 501     Protein Phosphatase 1, Regulatory Subunit 502
Bcl-22     

External Ids:    HGNC: 9901   Entrez Gene: 5962   Ensembl: ENSG000001717917   OMIM: 1514305   UniProtKB: P104153   

Export aliases for BCL2 gene to outside databases

Previous GC identifers: GC18M060629 GC18M058939 GC18M058941 GC18M057487


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCL2 Gene:
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells
such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy
chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate
splicing, differ in their C-terminal ends. (provided by RefSeq, Jul 2008)

GeneCards Summary for BCL2 Gene:
BCL2 (B-cell CLL/lymphoma 2) is a protein-coding gene. Diseases associated with BCL2 include follicular lymphoma, and leukemia/lymphoma, b-cell, 2. GO annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is BAK1.

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and
neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in
a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c
from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

summary for BCL2 Gene:
Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein
family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as
Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2
proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma
and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members
contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial
and other intracellular membranes.

Gene Wiki entry for BCL2 (Bcl-2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCL2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCL2 promoter sequence
   Search Chromatin IP Primers for BCL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.3

BCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M060763:  view genomic region     (about GC identifiers)

Start:
60,790,579 bp from pter      End:
60,987,361 bp from pter
Size:
196,783 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415 (See protein sequence)
Recommended Name: Apoptosis regulator Bcl-2  
Size: 239 amino acids; 26266 Da
Subunit: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires
intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Interacts with EI24 (By
similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target
BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in
an ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via
the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the
anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the
anti-apoptotic BAX-BCL2 complex. Interacts with BOP
Selected PDB 3D structures from and Proteopedia for BCL2 (see all 13):
1G5M (3D)        1GJH (3D)        1YSW (3D)        2O21 (3D)        2O22 (3D)        2O2F (3D)    
Secondary accessions: P10416 Q13842 Q16197
Alternative splicing: 2 isoforms:  P10415-1   P10415-2   

Explore the universe of human proteins at neXtProt for BCL2: NX_P10415

Explore proteomics data for BCL2 at MOPED

Post-translational modifications: 

  • Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated
    phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of
    the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such
    as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates
    starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity)1
  • Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has
    pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity1
  • Monoubiquitinated by PARK2, leading to increase its stability1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BCL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000624.2  NP_000648.2  

    ENSEMBL proteins: 
     ENSP00000381185   ENSP00000329623   ENSP00000466417   ENSP00000404214  
    Reactome Protein details: P10415

    BCL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BCL2 (Bcl-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCL2
    OriGene Protein Over-expression Lysate for BCL2
    OriGene MassSpec for BCL2
    OriGene Custom Protein Services for BCL2
    GenScript Custom Purified and Recombinant Proteins Services for BCL2
    Novus Biologicals BCL2 Proteins
    Sino Biological Recombinant Protein for BCL2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BCL2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for BCL2 

     
    antibodies-online proteins for BCL2 (19 products) 

     
    antibodies-online peptides for BCL2

    BCL2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2
    R&D Systems Antibodies for BCL2 (Bcl-2)
    Cell Signaling Technology (CST) Antibodies for BCL2  (Bcl-2)
    OriGene Antibodies for BCL2
    OriGene Custom Antibody Services for BCL2
    Novus Biologicals BCL2 Antibodies
    Abcam antibodies for BCL2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for BCL2
    LSBio Antibodies in human, mouse, rat for BCL2
    antibodies-online antibodies for BCL2 (504 products) 

    BCL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCL2
    R&D Systems ELISAs for BCL2 (Bcl-2)         (see all)
    GenScript Custom Assay Services for BCL2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for BCL2 (Bcl-2)
    Enzo Life Sciences assays for BCL2
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for BCL2:  
                        Human Bcl-2 Platinum ELISA 96 tests
    antibodies-online kits for BCL2 (22 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    Selected InterPro protein domains (see all 9):
     IPR020728 Bcl2_BH3_motif_CS
     IPR013278 Apop_reg_Bcl2
     IPR020717 Bcl2_BH1_motif_CS
     IPR004725 Bcl2/BclX
     IPR020726 Bcl2_BH2_motif_CS

    Graphical View of Domain Structure for InterPro Entry P10415

    ProtoNet protein and cluster: P10415

    2 Blocks protein domains:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
    Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3
    Similarity: Belongs to the Bcl-2 family


    Find genes that share domains with BCL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCL2_HUMAN, P10415
    Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and
    neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in
    a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c
    from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

         Genatlas biochemistry entry for BCL2:
    inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by inhibiting the release
    of cytochrome from the mitochondrial and by protecting a wide variety of cells including B cells and neuronal
    cells,activated by nerve growth factor,mediated by the p42/p44 MAPK cascade,inhibited by phosphorylation mediated
    by microtubule-damaging drugs through JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also
    modulating CDK2 activation during thymocyte apoptosis,overexpressed in endometrial carcinoma

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IDA10620603
    GO:0005515protein binding IPI10837489
    GO:0008134transcription factor binding IEA--
    GO:0015267channel activity IDA9219694
    GO:0016248channel inhibitor activity IDA9219694
         
    Find genes that share ontologies with BCL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL2:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Bcl2) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 

    Find genes that share phenotypes with BCL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BCL2: Bcl2tm1Dlo Bcl2tm1Sjk Bcl2tm1Tsu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCL2:
    hsa-mir-200b-3p (MIRT006670), hsa-mir-630 (MIRT005578), hsa-mir-34c-5p (MIRT003979), hsa-mir-7-5p (MIRT006904), hsa-let-7a-5p (MIRT000418), hsa-mir-181d-5p (MIRT003498), hsa-mir-365a-3p (MIRT006243), hsa-mir-29b-3p (MIRT003290), hsa-mir-24-2-5p (MIRT006977), hsa-mir-200c-3p (MIRT006673), hsa-mir-20a-5p (MIRT003011), hsa-mir-451a (MIRT005744), hsa-mir-148a-3p (MIRT006975), hsa-mir-181a-5p (MIRT003501), hsa-mir-17-5p (MIRT003014), hsa-mir-449a (MIRT006445), hsa-mir-21-5p (MIRT000159), hsa-mir-29c-3p (MIRT003289), hsa-mir-34a-5p (MIRT002298), hsa-mir-96-5p (MIRT027929), hsa-mir-196b-5p (MIRT007146), hsa-mir-153-3p (MIRT000290), hsa-mir-16-5p (MIRT001800), hsa-mir-182-5p (MIRT007063), hsa-mir-34b-5p (MIRT000065), hsa-mir-125b-5p (MIRT006253), hsa-mir-181c-5p (MIRT003499), hsa-mir-136-5p (MIRT006868), hsa-mir-15b-5p (MIRT000978), hsa-mir-215-5p (MIRT024494), hsa-mir-15a-5p (MIRT000815), hsa-mir-143-3p (MIRT007348), hsa-mir-103a-3p (MIRT027158), hsa-mir-204-5p (MIRT000192), hsa-mir-29a-3p (MIRT003291), hsa-mir-429 (MIRT006674), hsa-mir-195-5p (MIRT005362), hsa-mir-181b-5p (MIRT003500), hsa-mir-192-5p (MIRT004844), hsa-mir-375 (MIRT019975)

    Block miRNA regulation of human, mouse, rat BCL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL2 (see all 117):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BCL2
    Predesigned siRNA for gene silencing in human, mouse, rat BCL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCL2

    Clone
    Products:
         
    OriGene clones in human, mouse for BCL2 (see all 15)
    OriGene ORF clones in mouse, rat for BCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
    Sino Biological Human cDNA Clone for BCL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2
    Addgene plasmids for BCL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for BCL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10189) for BCL2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BCL2_HUMAN, P10415: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass
    membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol3
    cytoskeleton2
    extracellular2
    plasma membrane2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA7546744
    GO:0005737cytoplasm IDA11530860
    GO:0005739mitochondrion IDA7896880
    GO:0005741mitochondrial outer membrane TAS--

    Find genes that share ontologies with BCL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCL2 About   (see all 83)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptotic Pathways Triggered By HIV10.42
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    Apoptosis through Death Receptors0.42
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    FAS pathway and Stress induction of HSP regulation0.44
    3Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    Amyotrophic lateral sclerosis (ALS)0.63
    4Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    Inflammasomes0.00
    Influenza A virus infection0.00
    The NLRP1 inflammasome0.00
    5Development HGF signaling pathway
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35
    Neurotrophin signaling pathway0.36


    Find genes that share SuperPaths with BCL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for BCL2
        IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Apoptosis Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Notch Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BCL2 (see all 48)
        FLT3 Signaling
    14-3-3 Induced Apoptosis
    IL-4 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for BCL2
        Apoptosis and Autophagy

    1 Tocris Bioscience Pathway for BCL2
        Apoptosis Pathway

    Selected GeneGo (Thomson Reuters) Pathways for BCL2 (see all 15)
        Apoptosis and survival BAD phosphorylation
    Transcription P53 signaling pathway
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    Apoptosis and survival FAS signaling cascades

    Selected BioSystems Pathways for BCL2 (see all 33)
        Focal Adhesion
    Apoptosis
    Apoptosis Modulation and Signaling
    Senescence and Autophagy
    Estrogen signaling pathway

    2 Sino Biological Pathways for BCL2
        p53 Pathway
    Death Receptor Signaling

    3 Reactome Pathways for BCL2
        The NLRP1 inflammasome
    Activation of BAD and translocation to mitochondria
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

    2 PharmGKB Pathways for BCL2
        Busulfan Pathway, Pharmacodynamics
    Vinka Alkaloid Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for BCL2) (see all 19):
        NF-kappa B signaling pathway
    HIF-1 signaling pathway
    Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Apoptosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL2 (see all 34): 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCL2 (P104151, 2, 3 ENSP000003296234) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53BP2Q136251, 2, 3, ENSP000003419574EBI-77694,EBI-77642 MINT-7235804 MINT-7235946 MINT-7235823 MINT-7236118 MINT-7236027 MINT-7236079 MINT-7236102 MINT-7236042 MINT-7236003 MINT-7235965 MINT-7235839 MINT-7236061 MINT-7235784 I2D: score=4 STRING: ENSP00000341957
    AMBRA1Q9C0C71, 2, 3, ENSP000003183134EBI-77694,EBI-2512975 MINT-8182706 MINT-8182670 MINT-8182688 MINT-8182559 MINT-8182625 MINT-8174974 MINT-8182589 MINT-8182650 MINT-8182607 MINT-8182574 I2D: score=1 STRING: ENSP00000318313
    BECN1Q144571, 2, 3, ENSP000003552314EBI-77694,EBI-949378 MINT-8182780 MINT-4821014 MINT-4820784 MINT-8095220 MINT-8182706 MINT-7014531 MINT-7712827 MINT-8095201 I2D: score=4 STRING: ENSP00000355231
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 148):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle ----
    GO:0000209protein polyubiquitination IDA16717086
    GO:0000902cell morphogenesis ----
    GO:0001101response to acid IEA--
    GO:0001503ossification IEA--

    Find genes that share ontologies with BCL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for BCL2
    Selected ApexBio Compounds for BCL2 (see all 19)     About this table
    CompoundAction CAS #
    2,3-DCPE hydrochlorideSelectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro[418788-90-6]
    ABT-199Selective Bcl-2 inhibitor[1257044-40-8]
    ABT-263 (Navitoclax)orally sellecitive inhibitor of Bcl-2 family proteins[923564-51-6]
    ABT-737novel and potent inhibitor of BCL-2 family proteins[852808-04-9]
    Apogossypolone (ApoG2)pan Bcl-2 inhibitor[886578-07-0]
    AT-101R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1[90141-22-3]
    Bax channel blockerPotent inhibitor of Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide P5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-83-4]
    Bax inhibitor peptide V5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-81-2]
    Bax inhibitor peptide, negative controlNegative control peptide for the Bax inhibitor peptides V5 and P5[1315378-74-5]

    Compounds for BCL2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AT 101Downregulates Bcl-2 and Mcl-1; pro-apoptotic[90141-22-3]
    HA14-1Bcl-2 inhibitor. Induces apoptosis[65673-63-4]
    MIM1Mcl-1 inhibitor; proapoptotic--
    Bax channel blockerInhibits Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide V5Inhibitor of Bax-mediated apoptosis[579492-81-2]

    4 DrugBank Compounds for BCL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DocetaxelDocetaxel anhydrous (see all 4)114977-28-5target--15643508 15161985 15714982 15685445 17674353 15277270
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4targetinhibitor17119350 16741658 17062688 16895478 17230521
    Rasagiline-- 136236-51-6targetactivator12057839 14555244 16148027 12043833 12200198
    IbuprofenIbuprophen (see all 3)15687-27-1targetmodulator22668799

    Selected Novoseek inferred chemical compound relationships for BCL2 gene (see all 126)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genasense 81.3 45 16584297 (3), 16564596 (3), 11751483 (2), 12393493 (1) (see all 24)
    noxa 75.3 52 19372561 (3), 17018621 (3), 16673057 (2), 19540835 (2) (see all 34)
    dutp 75.2 39 9212738 (1), 11920781 (1), 12210368 (1), 14761612 (1) (see all 38)
    adpribose 71.7 49 12490780 (2), 11328292 (1), 11896536 (1), 18767861 (1) (see all 44)
    paclitaxel 71.3 393 9716607 (8), 9699642 (7), 19671798 (6), 10097113 (6) (see all 99)
    etoposide 68.8 137 10367743 (4), 8752171 (4), 9554589 (4), 8395979 (4) (see all 86)
    doxorubicin 66.8 175 8781438 (6), 12579337 (3), 18498876 (3), 19818735 (3) (see all 96)
    oridonin 66.3 15 17260801 (3), 15008459 (2), 15703811 (2), 16638644 (1) (see all 10)
    3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 66.1 6 12144824 (1), 15033191 (1), 18471799 (1), 15749633 (1) (see all 6)
    paraffin 65.4 126 9343323 (4), 9521469 (1), 10652623 (1), 10491515 (1) (see all 99)

    3 PharmGKB related drug/compound annotations for BCL2 gene    About this table
    Drug/compound PharmGKB Annotation
    carboplatinCA  
    docetaxelCA  
    paclitaxelCA  



    Find genes that share compounds with BCL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BCL2 gene (2 alternative transcripts): 
    NM_000633.2  NM_000657.2  

    Unigene Cluster for BCL2:

    B-cell CLL/lymphoma 2
    Hs.150749  [show with all ESTs]
    Unigene Representative Sequence: NM_000633
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398117(uc002liu.1) ENST00000333681(uc002lit.1) ENST00000590515
    ENST00000589955 ENST00000444484(uc002liv.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BCL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL2 (see all 117):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BCL2
    Predesigned siRNA for gene silencing in human, mouse, rat BCL2
    Clone
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    OriGene clones in human, mouse for BCL2 (see all 15)
    OriGene ORF clones in mouse, rat for BCL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2
    Addgene plasmids for BCL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BCL2
    OriGene qSTAR qPCR primer pairs in human, mouse for BCL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCL2
      QuantiTect SYBR Green Assays in human, mouse, rat BCL2
      QuantiFast Probe-based Assays in human, mouse, rat BCL2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10189) for BCL2 

    Additional mRNA sequence: 

    AF401211.1 BC027258.1 EU287875.1 M13994.1 M13995.1 M14745.1 X06487.1 

    4 DOTS entries:

    DT.216205  DT.100749960  DT.86998979  DT.40316825 

    Selected AceView cDNA sequences (see all 148):

    BG503428 BM986952 CB118071 F07940 F04196 AI480094 BM463468 AW241434 
    N42615 AF401211 BE550816 AI142026 BQ440944 BU195508 AA321638 BQ215366 
    N29770 AI261915 BQ224622 BF222234 AI391699 BU159596 BM996398 BG388287 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for BCL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGGAGA
    BCL2 Expression
    About this image


    BCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Odontoblasts Dentin
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Epidermis (Integumentary System)    fully expand to see all 5 entries
             Intermediate Keratinocytes Embryonic Epidermis
    BCL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150749

    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
    Tissue specificity: Expressed in a variety of tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCL2 (see all 34): 
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for BCL2
    OriGene qSTAR qPCR primer pairs in human, mouse for BCL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCL2
    QuantiTect SYBR Green Assays in human, mouse, rat BCL2
    QuantiFast Probe-based Assays in human, mouse, rat BCL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BCL2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl21 , 5 B cell leukemia/lymphoma 21, 5 88.28(n)1
    90.25(a)1
      1 (49.76 cM)5
    120431  NM_009741.41  NP_033871.21 
     1065381785 
    chicken
    (Gallus gallus)
    Aves BCL21 B-cell CLL/lymphoma 2 74.62(n)
    77.03(a)
      396282  NM_205339.1  NP_990670.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL26
    B-cell CLL/lymphoma 2
    71(a)
    1 ↔ 1
    GL344304.1(26465-27025)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bcl21 B-cell CLL/lymphoma 2 62.9(n)
    63.6(a)
      100485267  XM_002934396.2  XP_002934442.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BCL2 (2 of 2)6
    bcl26
    B-cell leukemia/lymphoma 2
    50(a)
    47(a)
    1 ↔ many
    1 ↔ many
    2(12977291-13008258) ENSDARG00000089109
    24(29060361-29151442) ENSDARG00000025613


    ENSEMBL Gene Tree for BCL2 (if available)
    TreeFam Gene Tree for BCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCL2 gene
    BAK12  BCL2L22  BCL2L12  
    4 SIMAP similar genes for BCL2 using alignment to 3 protein entries:     BCL2_HUMAN (see all proteins):
    bcl-2    BCL2L2-PABPN1    BCL2L2    BCL2L1

    Find genes that share paralogs with BCL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCL2 (see all 4066)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0008284
    Non-Hodgkin lymphoma4--see VAR_0008282 P S mis40--------
    VAR_0008294
    Non-Hodgkin lymphoma4--see VAR_0008292 V I mis40--------
    rs1883577131,2
    --57557443(+) TGGGGA/GGATGC 1 -- int10--------
    rs49405701,2
    C,F--57557629(+) ATTTCA/GGGATT 1 -- int13Minor allele frequency- G:0.26WA NA EA 358
    rs729394581,2
    C,F--57557709(+) GTGAGT/AGTGAA 1 -- int12Minor allele frequency- A:0.08NA EA 240
    rs1452288511,2
    --57557742(+) CTGTAC/TAGATG 1 -- int10--------
    rs1476544151,2
    --57557778(+) ATACTA/GCTGTT 1 -- int10--------
    rs1158571541,2
    C,F--57557864(+) TAGCTC/TGTTTG 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1926420051,2
    --57557871(+) TTTGCC/TGGCCC 1 -- int10--------
    rs1854366011,2
    --57557976(+) CCTTGA/GTGTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for BCL2 (60790579 - 60987361 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BCL2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2086747CNV Deletion18987734
    esv2667157CNV Deletion23128226
    esv2717200CNV Deletion23290073
    esv2717199CNV Deletion23290073
    esv2571485CNV Deletion19546169
    esv1187842CNV Insertion17803354
    nsv2334CNV Insertion18451855
    esv1004886CNV Insertion20482838
    nsv131879CNV Insertion16902084
    esv1611780CNV Insertion17803354

    Human Gene Mutation Database (HGMD): BCL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL2
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151430    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
  • Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation
    t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the
    chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide
    transitions

  • Selected diseases for BCL2 (see all 35):    
    About MalaCards
    follicular lymphoma    leukemia/lymphoma, b-cell, 2    benign mammary dysplasia    adenoid cystic carcinoma
    malignant teratoma    lymphoma, follicular, somatic    keratinizing squamous cell carcinoma    intravascular large b-cell lymphoma
    cervical carcinosarcoma    lymphosarcoma    biphasic synovial sarcoma    superficial basal cell carcinoma
    extramedullary plasmacytoma    gastrointestinal lymphoma    benign metastasizing leiomyoma    natural killer cell leukemia
    seborrheic keratosis    spindle cell sarcoma    oculopharyngeal muscular dystrophy    intraocular lymphoma

    6 diseases from the University of Copenhagen DISEASES database for BCL2:
    Lymphoma     Leukemia     Carcinoma     Breast cancer
    Lung cancer     Vascular disease

    Find genes that share disorders with BCL2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BCL2 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma follicular 87.1 381 18945749 (7), 2223650 (5), 18925696 (5), 9349233 (4) (see all 99)
    tumors 83.8 3055 2214188 (7), 9002964 (7), 17295204 (6), 15667975 (6) (see all 99)
    lymphoma b-cell 82.4 319 18925696 (5), 20459572 (4), 8639245 (3), 9242549 (3) (see all 99)
    lymphoma 78.3 595 16373664 (5), 1890741 (5), 11431360 (5), 8371594 (5) (see all 99)
    cancer 77.8 713 9416483 (5), 11728179 (5), 9000560 (4), 16531274 (4) (see all 99)
    leukemia 74.3 316 18422996 (5), 10456672 (4), 10023011 (4), 20350424 (4) (see all 99)
    breast cancer 70.7 671 20068093 (5), 19762066 (5), 11235572 (5), 17288732 (5) (see all 99)
    necrosis 69.1 225 10064615 (4), 10464427 (3), 19331832 (3), 10754212 (2) (see all 99)
    lymphoma non-hodgkins 68.1 150 15503680 (3), 11380403 (3), 9113013 (3), 1747446 (2) (see all 99)
    lymphocytic leukemia chronic b-cell 67.8 31 8104532 (2), 9373241 (1), 17132110 (1), 8260892 (1) (see all 27)

    Genatlas disease: BCL2
    non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation
    t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated lymphoid
    tissue),with translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between BCL2 and DCC

    Genetic Association Database (GAD): BCL2
    Human Genome Epidemiology (HuGE) Navigator: BCL2 (73 documents)
    Tumor Gene Database (TGDB): BCL2

    Export disorders for BCL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCL2 gene, integrated from 10 sources (see all 7276) (see top 10):
    (articles sorted by number of sources associating them with BCL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Germline BCL-2 sequence variants and inherited predisposition to prostate cancer. (PubMed id 16733517)1, 4, 9 Kidd L.R....Kittles R.A. (Prostate Cancer Prostatic Dis. 2006)
    2. Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. (PubMed id 20087644)1, 4, 9 Fernberg P....EkstrAPm Smedby K. (amp 2010)
    3. p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. (PubMed id 15849194)1, 2, 9 Jin S.... Field J. (J. Biol. Chem. 2005)
    4. Interaction between BCL2 and interleukin-10 gene polymorphisms alter outcomes of diffuse large B-cell lymphoma following rituximab plus CHOP chemotherapy. (PubMed id 19276283)1, 4, 9 Park Y.H....Kim D.H. (Clin. Cancer Res. 2009)
    5. The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C&gt;A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients. (PubMed id 17908970)1, 4, 9 Bachmann H.S....Kimmig R. (Clin. Cancer Res. 2007)
    6. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. (PubMed id 10567572)1, 2, 9 Yamamoto K.... Korsmeyer S.J. (Mol. Cell. Biol. 1999)
    7. Association of a novel regulatory polymorphism (-938C&gt;A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia. (PubMed id 16960146)1, 4, 9 NA1ckel H....Siffert W. (Blood 2007)
    8. Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (PubMed id 17534194)1, 4, 9 Ester A.R....Hecht J.T. (Clin. Orthop. Relat. Res. 2007)
    9. Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. (PubMed id 16148027)1, 7, 9 Bar-Am O....Youdim M.B. (FASEB J. 2005)
    10. Phosphorylation of Bcl2 and regulation of apoptosis. (PubMed id 11368354)1, 2, 9 Ruvolo P.P.... May W.S. (Leukemia 2001)
    11. Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (PubMed id 11325850)1, 4, 9 Tsukasaki K....Koeffler H.P. (Cancer Res. 2001)
    12. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. (PubMed id 1339299)1, 2, 9 Tanaka S.... Reed J.C. (Blood 1992)
    13. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. (PubMed id 2250705)1, 2, 9 Hockenbery D.... Korsmeyer S.J. (Nature 1990)
    14. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PubMed id 20157331)1, 4 Edvardsen H....Kristensen V.N. (Pharmacogenomics J. 2010)
    15. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    16. BCL2 Ala43Thr is a functional variant associated with protection against azoospermia in a Han-Chinese population. (PubMed id 20610805)1, 4 Ma J....Wang S.L. (Biol. Reprod. 2010)
    17. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    18. BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury. (PubMed id 20504155)1, 4 Hoh N.Z....Conley Y.P. (J. Neurotrauma 2010)
    19. BCL2 gene polymorphism could predict the treatment outcomes in acute myeloid leukemia patients. (PubMed id 19520430)1, 4 Moon J.H....Kim D.H. (Leuk. Res. 2010)
    20. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    21. The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia. (PubMed id 20959405)1, 4 Kim D.H....Lipton J.H. (Clin. Cancer Res. 2010)
    22. TNF superfamily gene polymorphism as prognostic factor in early breast cancer. (PubMed id 19890662)1, 4 Jung J.H....Park H.Y. (J. Cancer Res. Clin. Oncol. 2010)
    23. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    24. Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. (PubMed id 20889974)1, 2 Chen D.... Wang G. (J. Biol. Chem. 2010)
    25. Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes. (PubMed id 20468060)1, 4 Sloan C.D....Saykin A.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    26. Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C&gt;T, BCL2-938C&gt;A, MCL1-386C&gt;G) in extrahepatic cholangiocarcinoma. (PubMed id 19968497)1, 4 Fingas C.D....Canbay A. (Cancer Invest. 2010)
    27. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    28. Lung cancer susceptibility model based on age, family history and genetic variants. (PubMed id 19390575)1, 4 Young R.P....Gamble G.D. (PLoS ONE 2009)
    29. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (PubMed id 19228691)1, 2 Eliseev R.A....Gunter T.E. (J. Biol. Chem. 2009)
    30. BCL2-938C&gt;A polymorphism and disease progression in chronic lymphocytic leukemia. (PubMed id 19883311)1, 4 Zenz T....NA1ckel H. (amp 2009)
    31. Association of the AA genotype of the BCL2 (-938C&gt;A) promoter polymorphism with better survival in ovarian cancer. (PubMed id 20082279)1, 4 Heubner M....NA1ckel H. (Int. J. Biol. Markers 2009)
    32. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    33. Genetic polymorphisms in the EGFR (R521K) and estrogen receptor (T594T) genes, EGFR and ErbB-2 protein expression, and breast cancer risk in Tunisia. (PubMed id 19636371)1, 4 Kallel I....RebaA^ A. (amp 2009)
    34. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    35. BCL2-938C&gt;A and CALCA-1786T&gt;C polymorphisms in aseptic loosened total hip arthroplasty. (PubMed id 19541585)1, 4 Wedemeyer C....Bachmann H.S. (Eur. J. Med. Res. 2009)
    36. Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. (PubMed id 19141860)1, 4 Kim D.H....Lipton J.H. (Blood 2009)
    37. Bcl2 -938C/A polymorphism carries increased risk of biochemical recurrence after radical prostatectomy. (PubMed id 19237173)1, 4 Hirata H....Dahiya R. (J. Urol. 2009)
    38. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    39. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PubMed id 19336552)1, 4 Morton L.M....Hartge P. (amp 2009)
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    295. Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. (PubMed id 19838163)1, 9 Zhuang L....Hersey P. (Mod. Pathol. 2010)
    296. Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. (PubMed id 20233885)1, 9 Nichols A.C....Rocco J.W. (Clin. Cancer Res. 2010)
    297. PKCepsilon induces Bcl-2 by activating CREB. (PubMed id 20198332)1, 9 Shankar E....Basu A. (Int. J. Oncol. 2010)
    298. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. (PubMed id 20010695)1, 9 Chang N.C.... Shore G.C. (EMBO J. 2010)
    299. Expression and significance of tumor drug resistance related proteins and beta-catenin in esophageal squamous cell carcinoma. (PubMed id 20193114)1, 9 Gan S.Y....Luo F. (Chin J Cancer 2010)
    300. Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. (PubMed id 19585117)1, 9 Zhao L....Guo Q.L. (Cancer Chemother. Pharmacol. 2010)
    301. Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia. (PubMed id 20001236)1, 9 Del Poeta G....Amadori S. (amp 2010)
    302. Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling. (PubMed id 20189983)1, 9 Eckenrode E.F....White C. (J. Biol. Chem. 2010)
    303. Downmodulation of Bcl-2 sensitizes metastatic LNCaP-LN3 cells to undergo apoptosis via the intrinsic pathway. (PubMed id 19938012)1, 9 Song R....Pettaway C.A. (Prostate 2010)
    304. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. (PubMed id 19834492)1, 9 Chen Z.X. and Pervaiz S. (Cell Death Differ. 2010)
    305. Hypoxia-induced Bcl-2 expression in endothelial cells via p38 MAPK pathway. (PubMed id 20307495)1, 9 Zhang C.L....Song Q.H. (Biochem. Biophys. Res. Commun. 2010)
    306. Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2. (PubMed id 19398149)1, 9 Siegelin M.D....Siegelin Y. (Cancer Lett. 2009)
    307. Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells. (PubMed id 18357521)1, 9 George J....Ray S.K. (Neurochem. Res. 2009)
    308. The apoptotic paradox in retinoblastoma. (PubMed id 19723039)1, 9 Sitorus R.S....van der Valk P. (Ann. N. Y. Acad. Sci. 2009)
    309. High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin's lymphoma. (PubMed id 18929412)1, 9 Green M....Griffiths L. (Leuk. Res. 2009)
    310. PPAR gamma protects cardiomyocytes against oxidative stress and apoptosis via Bcl-2 upregulation. (PubMed id 19540934)1, 9 Ren Y....Wu Z. (Vascul. Pharmacol. 2009)
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    312. Expression of apoptosis related proteins in normal and diseased muscle: a possible role for Bcl-2 in protection of striated muscle. (PubMed id 19477129)1, 9 Danielsson O....Ernerudh J. (Neuromuscul. Disord. 2009)
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    314. Adrenomedullin, Bcl-2 and microvessel density in normal, hyperplastic and neoplastic endometrium. (PubMed id 19627536)1, 9 Nunobiki O....Kakudo K. (Pathol. Int. 2009)
    315. Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death. (PubMed id 19318089)1, 9 Park K.J....Kim Y.S. (Biochem. Biophys. Res. Commun. 2009)
    316. MRP- and BCL-2-mediated drug resistance in human SCLC: effects of apoptotic sphingolipids in vitro. (PubMed id 19195736)1, 9 Khodadadian M....Klostergaard J. (Lung Cancer 2009)
    317. Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells. (PubMed id 19996270)1, 9 Cui J....Zhang J. (Mol. Cancer Ther. 2009)
    318. BCL-2, BAX and P53 expression profiles in endometrial carcinoma as studied by real-time PCR and immunohistochemistry. (PubMed id 19846939)1, 9 Porichi O....Panotopoulou E. (Anticancer Res. 2009)
    319. Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells. (PubMed id 19124070)1, 9 Jin C.Y....Choi Y.H. (Toxicol In Vitro 2009)
    320. Short-term efficacy of rituximab-CHOP and CHOP regimens on two subtypes of diffuse large B-cell lymphoma. (PubMed id 19550126)1, 9 Xia Y....Huang H.Q. (Ai Zheng 2009)
    321. Correlation between histological type and immunohistochemical profile of prostate cancer and gleason scale gradation. (PubMed id 20010526)1, 9 Iemelynova A.A....Romanenko A.M. (Exp. Oncol. 2009)
    322. Targeting the Bcl-2 family of proteins in Hodgkin lymphoma: in vitro cytotoxicity, target modulation and drug combination studies of the Bcl-2 homology 3 mimetic ABT-737. (PubMed id 19557638)1, 9 Jayanthan A....Narendran A. (amp 2009)
    323. Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration. (PubMed id 19724860)1, 9 Jiao J....Lu Z. (Oncol. Rep. 2009)
    324. Bcl-2 in combination to myeloid antigen expression in adult acute lymphoblastic leukemia and prognostic outcome. (PubMed id 19725224)1, 9 Amirghofran Z....Gholijani N. (Oncol. Res. 2009)
    325. FOXP1 and BCL2 show similar immunoenzymatic pattern in bone marrow trephines of chronic lymphocytic leukemia patients. (PubMed id 19417623)1, 9 KoraA8 P....Dominis M. (amp 2009)
    326. Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy. (PubMed id 18516673)1, 9 Yang Q....Haffty B.G. (Breast Cancer Res. Treat. 2009)
    327. Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1. (PubMed id 19805519)1, 9 Chen S....Grant S. (Mol. Cell. Biol. 2009)
    328. P53 and BCL-2 as prognostic markers in endometrial carcinoma. (PubMed id 18398703)1, 9 Appel M.L....Dos Reis R. (Pathol. Oncol. Res. 2008)
    329. Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells. (PubMed id 18675369)1, 9 Lin D....Chen W. (Cell Biol. Int. 2008)
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    331. The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. (PubMed id 18046449)1, 9 Ploner C....Kofler R. (Leukemia 2008)
    332. Expression of multidrug resistance genes in normal and cancer stem cells. (PubMed id 18568776)1, 9 Shervington A. and Lu C. (Cancer Invest. 2008)
    333. The BCL-2 promoter (-938C&gt;A) polymorphism does not predict clinical outcome in chronic lymphocytic leukemia. (PubMed id 18046447)1, 9 Kaderi M.A....Rosenquist R. (Leukemia 2008)
    334. Epithelial cell turnover, p53 and bcl-2 protein expression during oncogenesis of early and advanced gastric cancer in a Western population. (PubMed id 18063429)1, 9 Triantafyllou K....Ladas S.D. (Dig Liver Dis 2008)
    335. Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels. (PubMed id 18375822)1, 9 Tucker C.A....Klasa R.J. (Mol. Cancer Ther. 2008)
    336. Statistical interpretation of CA125 and Bcl-2 in serum of patients with late stage ovarian cancer. (PubMed id 19060592)1, 9 Camlica H....Yasasever V. (Am. J. Clin. Oncol. 2008)
    337. BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A&gt;C promoter single nucleotide polymorphism. (PubMed id 17959858)1, 9 Majid A....Dyer M.J. (Blood 2008)
    338. Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. (PubMed id 18561741)1, 9 Looi M.L....Yusof Y.A. (Anal. Quant. Cytol. Histol. 2008)
    339. Expression of bcl-2 in breast cancer: correlation with clinicopathological characteristics and survival. (PubMed id 18998362)1, 9 Cecka F....KlozovA!-UrminskA! H. (Acta Medica (Hradec Kralove) 2008)
    340. Bcl-2 overexpression attenuates SP600125-induced apoptosis in human leukemia U937 cells. (PubMed id 18343029)1, 9 Moon D.O....Kim G.Y. (Cancer Lett. 2008)
    341. [Relationship between apoptotic effect of Resveratrol on KG-1 cells and expression of bcl-2/bax]. (PubMed id 18928588)1, 9 Li Y.J. and Xu H.J. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    342. A pilot surrogate endpoint biomarker study of celecoxib in oral premalignant lesions. (PubMed id 19138978)1, 9 Wirth L.J....Bertagnolli M.M. (Cancer Prev Res (Phila) 2008)
    343. Effect of anticancer drugs on production of transforming growth factor and expression of p53 AND Bcl-2 proteins by MCF-7 and T47D cell lines of human breast carcinoma. (PubMed id 18438339)1, 9 Stoika R.S....Vorontsova A.L. (Exp. Oncol. 2008)
    344. Bcl-2 expression significantly correlates with thymidylate synthase expression in colorectal cancer patients. (PubMed id 18985814)1, 9 Bendardaf R....Pyrhonen S. (World J. Gastroenterol. 2008)
    345. A novel fusion 5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma. (PubMed id 18622426)1, 9 Impera L....Storlazzi C.T. (Oncogene 2008)
    346. t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism. (PubMed id 18199533)1, 9 Belkhiri A....El-Rifai W. (Cancer Res. 2008)
    347. Neoadjuvant docetaxel treatment for locally advanced prostate cancer: a clinicopathologic study. (PubMed id 17674353)7, 9 Magi-Galluzzi C....Klein E.A. (Cancer 2007)
    348. CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway. (PubMed id 17516030)1, 9 Yun X....Gu J. (Mol. Cell. Biochem. 2007)
    349. siRNA-mediated Bcl-2 and Bcl-xl gene silencing sensitizes human hepatoblastoma cells to chemotherapeutic drugs. (PubMed id 17439414)1, 9 Lei X.Y....Liao D.F. (amp 2007)
    350. CREB-mediated Bcl-2 expression in trichosanthin-induced Hela cell apoptosis. (PubMed id 17825790)1, 9 Wang P....Li J.C. (Biochem. Biophys. Res. Commun. 2007)
    351. By blocking apoptosis, Bcl-2 in p38-dependent manner promotes cell cycle arrest and accelerated senescence after DNA damage and serum withdrawal. (PubMed id 17882791)1, 9 Nelyudova A....Pospelova T. (Cell Cycle 2007)
    352. Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. (PubMed id 17241114)1, 9 Johnson-Anuna L.N....Wood W.G. (J. Neurochem. 2007)
    353. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. (PubMed id 17256834)2, 9 Bruncko M....Elmore S.W. (J. Med. Chem. 2007)
    354. Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells. (PubMed id 17616686)1, 9 Wu M....Sonenshein G.E. (Cancer Res. 2007)
    355. The role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical cancer. (PubMed id 17713095)1, 9 TA1rkAsA1oA9lu I....SertAselik A. (Eur. J. Gynaecol. Oncol. 2007)
    356. Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains. (PubMed id 17426248)1, 9 Olejniczak E.T....Semizarov D. (Mol. Cancer Res. 2007)
    357. Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition. (PubMed id 17848408)1, 9 Mitsiades C.S....Mitsiades N. (J. Clin. Endocrinol. Metab. 2007)
    358. Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. (PubMed id 17384650)1, 9 Zhuang L....Hersey P. (Mod. Pathol. 2007)
    359. Non-small cell lung carcinoma: cyclin D1, bcl-2, p53, Ki-67 and HER-2 proteins expression in resected tumors. (PubMed id 17848143)1, 9 RadoviA8 S....SerdareviA8 F. (Bosn J Basic Med Sci 2007)
    360. Bcl-2 over-expression promotes genomic instability by inhibiting apoptosis of cells exposed to hydrogen peroxide. (PubMed id 17434928)1, 9 Cox A.G. and Hampton M.B. (Carcinogenesis 2007)
    361. A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. (PubMed id 17785460)1, 9 Steinberg R....Mason J.C. (J. Biol. Chem. 2007)
    362. The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. (PubMed id 16481323)1, 9 Milanesi E....Bernardi P. (J. Biol. Chem. 2006)
    363. Patterns of expression of cell cycle/apoptosis genes along the spectrum of thyroid carcinoma progression. (PubMed id 17188136)1, 9 Saltman B....Ghossein R. (Surgery 2006)
    364. Association between telomere length and BCL2 gene rearrangements in low- and high-grade non-Hodgkin lymphomas. (PubMed id 17074584)1, 9 HaydeAc Cottliar A.S....Slavutsky I.R. (Cancer Genet. Cytogenet. 2006)
    365. Impaired kinetics of Bax-GFP and Smac/DIABLO-GFP in caspase-8- and bid-silenced and Bcl-2 overexpressed breast cancer MCF-7 cells exposed to camptothecin. (PubMed id 17666167)1, 9 GA^rka M....Motyl T. (Cell. Mol. Biol. (Noisy-le-grand) 2006)
    366. Bcl-2 phosphorylation has pathological significance in human breast cancer. (PubMed id 17119350)7, 9 Matsuyoshi S....Konishi N. (Pathobiology 2006)
    367. The bcl-2 major breakpoint region (mbr) possesses transcriptional regulatory function. (PubMed id 16777355)1, 9 Zhang J....Sun Y. (Gene 2006)
    368. Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. (PubMed id 16550596)1, 9 Shimizu D....Danenberg P.V. (Int. J. Cancer 2006)
    369. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. (PubMed id 16717086)1, 9 Lin S.S....Roberts T.M. (J. Biol. Chem. 2006)
    370. Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy. (PubMed id 17062688)7, 9 Yoshino T....Igawa M. (Clin. Cancer Res. 2006)
    371. Prognostic value of immunohistochemical staining of p53, bcl-2, and Ki-67 in small cell lung cancer. (PubMed id 16479062)1, 9 Paik K.H....Chung J.H. (J. Korean Med. Sci. 2006)
    372. Bax and Bcl-2 protein expression in gastric precancerous lesions: immunohistochemical study. (PubMed id 16246184)1, 9 Anagnostopoulos G.K....Agnantis N.J. (J. Gastroenterol. Hepatol. 2005)
    373. Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells. (PubMed id 15735709)1, 9 Zheng Y....Chen Q. (Oncogene 2005)
    374. (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance. (PubMed id 15657350)1, 9 Oliver C.L....Johnson D.E. (Mol. Cancer Ther. 2005)
    375. Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. (PubMed id 15817479)1, 9 Lin C.F....Lin Y.S. (J. Biol. Chem. 2005)
    376. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. (PubMed id 15901672)1, 9 Willis S.N....Huang D.C. (amp 2005)
    377. Bcl-2 overexpression enhances in vitro sensitivity against docetaxel in non-small cell lung cancer. (PubMed id 15643508)7, 9 Inoue Y....Kobayashi K. (Oncol. Rep. 2005)
    378. Mechanisms of apoptosis of T-cells in human tuberculosis. (PubMed id 16133992)1, 9 Hirsch C.S....Toossi Z. (J. Clin. Immunol. 2005)
    379. Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells. (PubMed id 15605273)1, 9 Lee S.H. and McCormick F. (J. Mol. Med. 2005)
    380. Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. (PubMed id 16199534)1, 9 Kim K.M....Lee Y.J. (J. Biol. Chem. 2005)
    381. Bcl-2 attenuates anticancer agents-induced apoptosis by sustained activation of Akt/protein kinase B in U937 cells. (PubMed id 16215670)1, 9 Woo K.J....Kwon T.K. (Apoptosis 2005)
    382. CD10 and Bcl-2 expression combined with the International Prognostic Index can identify subgroups of patients with diffuse large-cell lymphoma with very good or very poor prognoses. (PubMed id 15720419)1, 9 Biasoli I....Spector N. (Histopathology 2005)
    383. Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. (PubMed id 15763593)1, 9 Cericatto R....Spritzer P.M. (Steroids 2005)
    384. Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. (PubMed id 15572421)1, 9 Xu Q....Maruo T. (J. Clin. Endocrinol. Metab. 2005)
    385. Expression of p53, Ki-67 and Bcl-2 in parathyroid adenoma and residual normal tissue. (PubMed id 15800682)1, 9 Hadar T....Koren R. (Pathol. Oncol. Res. 2005)
    386. Chemotherapy for androgen-independent prostate cancer. (PubMed id 15685445)7, 9 Petrylak D.P. (World J Urol 2005)
    387. A phase I trial of a Bcl-2 antisense (G3139) and weekly docetaxel in patients with advanced breast cancer and other solid tumors. (PubMed id 15277270)7, 9 Marshall J....Hayes D.F. (Ann. Oncol. 2004)
    388. Quantitative analysis of bcl-2 expression in normal and leukemic human B-cell differentiation. (PubMed id 14724650)1, 9 Menendez P....Orfao A. (Leukemia 2004)
    389. Low frequency of bcl-2 expression in large non-polypoid colonic neoplasms. (PubMed id 15303767)1, 9 Yamada H....Fujii H. (J. Int. Med. Res. 2004)
    390. Preclinical pharmacology of the taxanes: implications of the differences. (PubMed id 15161985)7, 9 Gligorov J. and Lotz J.P. (Oncologist 2004)
    391. BCL-2-induced glioma cell invasiveness depends on furin-like proteases. (PubMed id 15584904)1, 9 Wick W....Weller M. (J. Neurochem. 2004)
    392. Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. (PubMed id 14699151)1, 9 Sorenson C.M. (J. Biol. Chem. 2004)
    393. Expression of survivin, bcl-2, P53 and bax in breast carcinoma and ductal intraepithelial neoplasia (DIN 1a). (PubMed id 15149158)1, 9 Kayaselcuk F....Seydioglu G. (amp 2004)
    394. Bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in B cells and de novo follicular lymphoma. (PubMed id 15561778)1, 9 Vanasse G.J....Harlan J.M. (Mol. Cancer Res. 2004)
    395. Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor. (PubMed id 14966123)1, 9 An J....Huang Z. (J. Biol. Chem. 2004)
    396. bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity. (PubMed id 14660675)1, 9 Trisciuoglio D....Del Bufalo D. (J. Biol. Chem. 2004)
    397. Bcl-2-mediated cell survival promotes metastasis of EpH4 betaMEKDD mammary epithelial cells. (PubMed id 15498929)1, 9 Pinkas J....Leder P. (Mol. Cancer Res. 2004)
    398. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. (PubMed id 15210690)1, 9 Jin Z....Deng X. (J. Biol. Chem. 2004)
    399. Relevance of p53, bcl-2 and Rb expression on resistance to cisplatin-based chemotherapy in advanced non-small cell lung cancer. (PubMed id 12499093)1, 9 Gregorc V....Tonato M. (Lung Cancer 2003)
    400. Bcl-2 controls caspase activation following a p53-dependent cyclin D1-induced death signal. (PubMed id 12480939)1, 9 Pratt M.A. and Niu M.Y. (J. Biol. Chem. 2003)
    401. Prognostic role of apoptotic, Bcl-2, c-erbB-2 and p53 tumor markers in salivary gland malignancies. (PubMed id 12759537)1, 9 Nagler R.M....Ben-Itzhak O. (Oncology 2003)
    402. Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2. (PubMed id 12939460)1, 9 Gupta S....Gollapudi S. (Mol. Cancer Ther. 2003)
    403. Bcl-2 expression in preinvasive and invasive cervical lesions. (PubMed id 12440815)1, 9 Ozalp S.S....Yildirim S. (Eur. J. Gynaecol. Oncol. 2002)
    404. Antisense oligonucleotides complementary to Bax transcripts reduce the susceptibility of B-cell chronic lymphocytic leukaemia cells to apoptosis in a bcl-2 independent manner. (PubMed id 12481899)1, 9 Pepper C....Bentley P. (amp 2002)
    405. Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia. (PubMed id 11877309)1, 9 Casato M....Kay J. (Blood 2002)
    406. Bcl-6 p53 mutations in lymphomas carrying the bcl-2/Jh rearrangement. (PubMed id 12217802)1, 9 Bellido M....NomdedAcu J.F. (Haematologica 2002)
    407. Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2. (PubMed id 11752215)1, 9 Liang Y....Schor N.F. (Mol. Pharmacol. 2002)
    408. Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. (PubMed id 11971816)1, 9 Rajah R....Cohen P. (amp 2002)
    409. Immunohistochemical expression of p53, Bcl-2, Bax, and Fas proteins in squamous cell carcinomas from immunosuppressed renal transplant recipients and immunocompetent individuals. (PubMed id 12270344)1, 9 SeAskin D....Turan M. (Transplant. Proc. 2002)
    410. [Relationship between expressions of telomerase genes and apoptosis related genes in mammary ductal atypical hyperplasia]. (PubMed id 12452037)1, 9 Song M....Song J.Y. (Ai Zheng 2002)
    411. Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes. (PubMed id 12200198)7, 9 Maruyama W....Naoi M. (Neurotoxicol Teratol 2002)
    412. Chemotherapy induces bcl-2 cleavage in lymphoid leukemic cell lines. (PubMed id 12533044)1, 9 Fortney J.E....Gibson L.F. (amp 2002)
    413. Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells. (PubMed id 12162425)1, 9 Koty P.P....Kagan V.E. (Mol. Cell. Biochem. 2002)
    414. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis. (PubMed id 11815602)1, 9 Pardo O.E....Seckl M.J. (J. Biol. Chem. 2002)
    415. In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions. (PubMed id 11804688)1, 9 Koty P.P....Levitt M.L. (Lung Cancer 2002)
    416. A novel function of BCL-2 overexpression in regulatory volume decrease. Enhancing swelling-activated Ca(2+) entry and Cl(-) channel activity. (PubMed id 11861644)1, 9 Shen M.R....Tang M.J. (J. Biol. Chem. 2002)
    417. bcl-2/bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal cancer. (PubMed id 11759059)1, 9 Scopa C.D....Tsamandas A.C. (amp 2001)
    418. Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. (PubMed id 11527400)1, 9 Antoku K....Johnson D.E. (Biochem. Biophys. Res. Commun. 2001)
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    436. The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737. (PubMed id 23341456)1 Boiani M....Marnett L.J. (J. Biol. Chem. 2013)
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    438. Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: its correlation with FLT3. (PubMed id 23906301)1 Mehta S.V....Vora H.H. (Neoplasma 2013)
    439. Bcl-2 level as a biomarker for 13q14 deletion in CLL. (PubMed id 23674504)1 Degheidy H.A....Marti G.E. (Cytometry B Clin Cytom 2013)
    440. Anti-cancer activity of DHA on gastric cancer--an in vitro and in vivo study. (PubMed id 23907579)1 Sun H....Zhang X. (Tumour Biol. 2013)
    441. Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer: a pilot study. (PubMed id 23126236)1 Marioni G....Blandamura S. (amp 2013)
    442. Involvement of the mitochondrial pathway and Bim/Bcl-2 balance in dihydroartemisinin-induced apoptosis in human breast cancer in vitro. (PubMed id 23138847)1 Mao H....Shao Q. (Int. J. Mol. Med. 2013)
    443. Prognostic value of mitotic index and Bcl2 expression in male breast cancer. (PubMed id 23573235)1 Lacle M.M....van Diest P.J. (PLoS ONE 2013)
    444. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. (PubMed id 23335369)1 Horn H....Ott G. (Blood 2013)
    445. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1. (PubMed id 22623155)1 Li L....Xie X. (Clin. Exp. Med. 2013)
    446. Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death. (PubMed id 24091677)1 Eichhorn J.M....Chambers T.C. (amp 2013)
    447. Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells. (PubMed id 23363601)1 Luanpitpong S....Rojanasakul Y. (Mol. Biol. Cell 2013)
    448. Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. (PubMed id 23733877)1 Santner-Nanan B....Nanan R. (J. Immunol. 2013)
    449. Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: implications for epigenetic regulation. (PubMed id 23261425)1 Lin J....Huang Z.S. (Biochem. Biophys. Res. Commun. 2013)
    450. Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation. (PubMed id 23263985)1 Cui X....Lieber M.R. (Mol. Cell. Biol. 2013)
    451. Prognostic value of bcl-2 expression among women with breast cancer in Libya. (PubMed id 23417836)1 Ermiah E....Collan Y. (Tumour Biol. 2013)
    452. Upregulation of Bcl-2 in nasal polyps from patients with cystic fibrosis. (PubMed id 23135964)1 Scapa V.I....Kingdom T.T. (amp 2013)
    453. Mesenchymal stem cell-like cells from children foreskin inhibit the growth of SGC-7901 gastric cancer cells. (PubMed id 23421973)1 Li Y....Xu W. (Exp. Mol. Pathol. 2013)
    454. Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies. (PubMed id 22484426)1 Leskov I....Chen J. (Oncogene 2013)
    455. Bcl-2 gene silencing by RNA interference inhibits the growth of the human gallbladder carcinoma cell line GBC-SD in vitro and in vivo. (PubMed id 23784204)1 Geng Z.M....Wang L. (Oncol. Rep. 2013)
    456. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. (PubMed id 24141421)1 Maejima Y....Sadoshima J. (Nat. Med. 2013)
    457. Getting away with murder: how does the BCL-2 family of proteins kill with immunity? (PubMed id 23527542)1 Renault T.T. and Chipuk J.E. (Ann. N. Y. Acad. Sci. 2013)
    458. RNA interference suppression of A100A4 reduces the growth and metastatic phenotype of human renal cancer cells via NF-kB-dependent MMP-2 and bcl-2 pathway. (PubMed id 23832737)1 Yang X.C....Zhao K. (Eur Rev Med Pharmacol Sci 2013)
    459. Contribution of Bcl-2 phosphorylation to Bak binding and drug resistance. (PubMed id 24097825)1 Dai H....Kaufmann S.H. (Cancer Res. 2013)
    460. Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice. (PubMed id 23613627)1 Sun X.C....Ye X.H. (World J. Gastroenterol. 2013)
    461. Another look at follicular lymphoma: immunophenotypic and molecular analyses identify distinct follicular lymphoma subgroups. (PubMed id 23509938)1 Marafioti T....Isaacson P.G. (Histopathology 2013)
    462. Daidzein induced apoptosis via down-regulation of Bcl-2/Bax and triggering of the mitochondrial pathway in BGC-823 cells. (PubMed id 22926545)1 Tang S....Hou L. (Cell Biochem. Biophys. 2013)
    463. BCL2 and BCLxL are key determinants of resistance to antitubulin chemotherapeutics in melanoma cells. (PubMed id 23802633)1 Watanabe A....Maesawa C. (Exp. Dermatol. 2013)
    464. Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression. (PubMed id 23359184)1 Liu P....Tu Z. (amp 2013)
    465. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. (PubMed id 23243017)1 Rahmani M....Grant S. (Cancer Res. 2013)
    466. The BCL-2 protein in precursor B acute lymphoblastic leukemia in children. (PubMed id 23511489)1 Chaber R....Chybicka A. (J. Pediatr. Hematol. Oncol. 2013)
    467. Correlation of nuclear morphometry of primary melanoma of the skin with clinicopathological parameters and expression of tumor suppressor proteins (p53 and p16(INK4a)) and bcl-2 oncoprotein. (PubMed id 23818364)1 Mijovic Z....Zdravkovic M. (J BUON 2013)
    468. AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells. (PubMed id 23812727)1 Li Q....Xiang T. (Tumour Biol. 2013)
    469. The VMP1-Beclin 1 interaction regulates autophagy induction. (PubMed id 23316280)1 Molejon M.I....Vaccaro M.I. (Sci Rep 2013)
    470. NF-I_B RNAi decreases the Bax/Bcl-2 ratio and inhibits TNF-I+-induced apoptosis in human alveolar epithelial cells. (PubMed id 23334076)1 Li L....Li W. (Inflamm. Res. 2013)
    471. Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. (PubMed id 23403511)1 Liu Y....Hao S. (Acta Biochim. Biophys. Sin. (Shanghai) 2013)
    472. B-cell Lymphoma 2 rs17757541 C&gt;G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population. (PubMed id 23991993)1 Li Q....Chen S.C. (Asian Pac. J. Cancer Prev. 2013)
    473. Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement. (PubMed id 23688426)1 Nagahara Y....Ikekita M. (Biochem. Biophys. Res. Commun. 2013)
    474. Beclin 1 and bcl-2 expressions in bladder urothelial tumors and their association with clinicopathological parameters. (PubMed id 23722017)1 Baspinar S....Kapucuoglu N. (Pathol. Res. Pract. 2013)
    475. Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications. (PubMed id 24240096)1 Ma P....Willbold D. (J. Biol. Chem. 2013)
    476. Pharmacological doses of melatonin induce alterations in mitochondrial mass and potential, bcl-2 levels and K+ currents in UVB-exposed U937 cells. (PubMed id 23364875)1 Canonico B....Papa S. (Cell Biol. Int. 2013)
    477. Tumor suppressor BLU promotes paclitaxel antitumor activity by inducing apoptosis through the down-regulation of Bcl-2 expression in tumorigenesis. (PubMed id 23628417)1 Park S.T....Rho S.B. (Biochem. Biophys. Res. Commun. 2013)
    478. Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation. (PubMed id 23588221)1 Zou M....Yu S. (Int. J. Oncol. 2013)
    479. Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia. (PubMed id 22198673)1 Liu M.E....Tsai S.J. (Age (Dordr) 2013)
    480. Protective role of AQP3 in UVA-induced NHSFs apoptosis via Bcl2 up-regulation. (PubMed id 23463292)1 Xie H....Li J. (Arch. Dermatol. Res. 2013)
    481. Assessment of BCL2/J(H) translocation in healthy individuals exposed to low-level radiation of 137CsCl in GoiAcnia, GoiA!s, Brazil. (PubMed id 23359021)1 Nunes H.F....da Cruz A.D. (Genet. Mol. Res. 2013)
    482. Reduced expressions of Fas and Bcl-2 proteins in CD14+ monocytes and normal CD14 soluble levels in juvenile systemic lupus erythematosus. (PubMed id 23846229)1 Liphaus B.L....Goldenstein-Schainberg C. (Lupus 2013)
    483. Synergistic effect of Bcl-2 and cyclin A2 on adverse recurrence-free survival in stage I non-small cell lung cancer. (PubMed id 23115005)1 Ko E....Kim D.H. (Ann. Surg. Oncol. 2013)
    484. Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability. (PubMed id 23822101)1 Zou J....Liu L. (Biochem. J. 2013)
    485. Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL proteins. (PubMed id 23960074)1 Zou H....Jiang Y. (J. Biol. Chem. 2013)
    486. Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma. (PubMed id 24157866)1 Zhen Y....Fang W. (amp 2013)
    487. [PPAR-I^ silencing inhibits the apoptosis of A549 cells by upregulating Bcl-2]. (PubMed id 23514940)1 Yang J. (Zhongguo Fei Ai Za Zhi 2013)
    488. Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic I^-cells. (PubMed id 22933114)1 Luciani D.S....Johnson J.D. (Diabetes 2013)
    489. MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. (PubMed id 23449635)1 Hu S....Young K.H. (Blood 2013)
    490. LRIG1 dictates the chemo-sensitivity of temozolomide (TMZ) in U251 glioblastoma cells via down-regulation of EGFR/topoisomerase-2/Bcl-2. (PubMed id 23850692)1 Qi X.C....Yang S.X. (Biochem. Biophys. Res. Commun. 2013)
    491. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes. (PubMed id 23437205)1 Liu M.E....Tsai S.J. (PLoS ONE 2013)
    492. MYC/BCL2 double-hit high-grade B-cell lymphoma. (PubMed id 23939148)1 Li S....Medeiros L.J. (Adv Anat Pathol 2013)
    493. Immunohistological expression of HIF-1I+, GLUT-1, Bcl-2 and Ki-67 in consecutive biopsies during chemoradiotherapy in patients with rectal cancer. (PubMed id 23030583)1 Havelund B.M....Jakobsen A. (APMIS 2013)
    494. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PubMed id 23770605)1 Berndt S.I....Slager S.L. (Nat. Genet. 2013)
    495. The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer. (PubMed id 23355004)1 Lasithiotaki I....Sourvinos G. (Int. J. Cancer 2013)
    496. Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation. (PubMed id 23283967)1 Vela L....Marzo I. (J. Biol. Chem. 2013)
    497. Safflor yellow B suppresses angiotensin II-mediated human umbilical vein cell injury via regulation of Bcl-2/p22(phox) expression. (PubMed id 23994555)1 Wang C....Wang C. (Toxicol. Appl. Pharmacol. 2013)
    498. High levels of bcl-2 protein expression do not correlate with genetic abnormalities but predict worse prognosis in patients with lymphoblastic lymphoma. (PubMed id 23494176)1 Gu Y....Zheng F. (Tumour Biol. 2013)
    499. Association of genetic markers in the BCL-2 family of apoptosis-related genes with endometrial cancer risk in a Chinese population. (PubMed id 23637776)1 Dorjgochoo T....Shu X.O. (PLoS ONE 2013)
    500. The regulation of apoptosis in intrauterine growth restriction: a study of Bcl-2 and Bax gene expression in human placenta. (PubMed id 23038985)1 BAPrzsAPnyi B....JoA^ J.G. (amp 2013)
    501. Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation. (PubMed id 23352961)1 Ewen C.L....Bleackley R.C. (Mol. Immunol. 2013)
    502. Placental apoptosis in preeclampsia, intrauterine growth retardation, and HELLP syndrome: an immunohistochemical study with caspase-3 and bcl-2. (PubMed id 23724505)1 Cali U....Danisman N. (amp 2013)
    503. Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status: a report from an International DLBCL rituximab-CHOP Consortium Program Study. (PubMed id 22929980)1 Visco C....DybkA ( 2013)
    504. Cytotoxicity of etoposide in cancer cell lines in vitro after BCL-2 and C-RAF gene silencing with antisense oligonucleotides. (PubMed id 23610963)1 Sypniewski D....SoA8tysik D. (Acta Pol Pharm 2013)
    505. Selenium compounds induced ROS-dependent apoptosis in myelodysplasia cells. (PubMed id 23900644)1 GonAsalves A.C....Sarmento-Ribeiro A.B. (Biol Trace Elem Res 2013)
    506. Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. (PubMed id 23564079)1 Zhou L....Wang G.H. (Acta Pharmacol. Sin. 2013)
    507. Autophagy and Bcl-2/BNIP3 death regulatory pathway in non-small cell lung carcinomas. (PubMed id 23216071)1 Karpathiou G....Giatromanolaki A. (APMIS 2013)
    508. Bcl-2 rs956572 polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder. (PubMed id 23072837)1 Soeiro-de-Souza M.G....Machado-Vieira R. (Neuropsychopharmacology 2013)
    509. NF-I_B activation fails to protect cells to TNFI+-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w. (PubMed id 23369735)1 Casanelles E....Yuste V.J. (Biochim. Biophys. Acta 2013)
    510. The expression patterns of pro-apoptotic and anti-apoptotic factors in human fetal and adult ovary. (PubMed id 23295106)1 Poljicanin A....Saraga-Babic M. (Acta Histochem. 2013)
    511. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. (PubMed id 23471820)1 Sanda T....Look A.T. (Cancer Discov 2013)
    512. Bcl-2-enhanced efficacy of microtubule-targeting chemotherapy through Bim overexpression: implications for cancer treatment. (PubMed id 23358890)1 Savry A....Bourgarel-Rey V. (Neoplasia 2013)
    513. BMI1 polycomb group protein acts as a master switch for growth and death of tumor cells: regulates TCF4-transcriptional factor-induced BCL2 signaling. (PubMed id 23671559)1 Siddique H.R....Saleem M. (PLoS ONE 2013)
    514. Prognostic significance of COX-2 expression and correlation with Bcl-2 and VEGF expression, microvessel density, and clinical variables in classical Hodgkin lymphoma. (PubMed id 23851330)1 Koh Y.W....Huh J. (Am. J. Surg. Pathol. 2013)
    515. Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth. (PubMed id 23479509)1 Trisciuoglio D....Del Bufalo D. (Neoplasia 2013)
    516. Prognostic significance of biological apoptosis factors in gastric cancer. (PubMed id 23613399)1 Sezer C....Bulbuller N. (J BUON 2013)
    517. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PubMed id 23247143)1 Yu B....Boerwinkle E. (Circ Cardiovasc Genet 2013)
    518. Decrease of survivin, p53 and Bcl-2 expression in chemorefractory colorectal liver metastases may be predictive of radiosensivity radiosensivity after radioembolization with yttrium-90 resin microspheres. (PubMed id 23497522)1 Melucci E....Mottolese M. (amp 2013)
    519. BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. (PubMed id 23480852)1 Beverly L.J....Siskind L.J. (Biochem. J. 2013)
    520. Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypolA acetate, in multiple myeloma inA vitro and inA vivo. (PubMed id 23708869)1 Lin J....Zhao Y. (Oncol. Rep. 2013)
    521. Effect of the BCL2 gene polymorphism on survival in advanced-stage non-small cell lung cancer patients who received chemotherapy. (PubMed id 23364242)1 Masago K....Mishima M. (Oncology 2013)
    522. miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. (PubMed id 22121083)1 Xu K....Liu J. (Mol. Carcinog. 2013)
    523. Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x(L): keep your friends close but your enemies closer. (PubMed id 23064052)1 Renault T.T....Manon S. (amp 2013)
    524. Oncogene PKCI/ controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2. (PubMed id 24127568)1 Niture S.K....Jaiswal A.K. (J. Cell. Sci. 2013)
    525. CIAPIN1 siRNA inhibits proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. (PubMed id 23151078)1 Yang Z....Zhang Q. (Curr Neurovasc Res 2013)
    526. Altered p16 and Bcl-2 expression reflects pathologic development in hydatidiform moles and choriocarcinoma. (PubMed id 23065465)1 Candelier J.J....Coullin P. (Pathol. Oncol. Res. 2013)
    527. Breakthrough in ER+ breast cancer. Specific gene's shutdown is detectable in blood; indicates cancer cell vulnerability, thus enabling earlier treatment. (PubMed id 24288815)1 (Duke Med Health News 2013)
    528. MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2. (PubMed id 23975374)1 Zhang R....Li L. (Tumour Biol. 2013)
    529. MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer. (PubMed id 23612742)1 Verdoodt B....Mirmohammadsadegh A. (Int. J. Oncol. 2013)
    530. SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein. (PubMed id 23673452)1 Kuo S.J....Chen D.R. (Oncol. Rep. 2013)
    531. BAX/BCL2 RMFI ratio predicts better induction response in pediatric patients with acute myeloid leukemia. (PubMed id 23553948)1 Sharawat S.K....Bakhshi S. (amp 2013)
    532. Bcl-2 gene expression in human breast cancers in iran. (PubMed id 23991978)1 Rostamizadeh L....Sakhinia E. (Asian Pac. J. Cancer Prev. 2013)
    533. Differences in epidermal thickness and expression of apoptosis regulatory proteins in the skin of patients with chronic renal failure and pruritus. (PubMed id 22748563)1 KovaA8eviA8 L.M....Saraga-BabiA8 M. (Acta Histochem. 2013)
    534. Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes. (PubMed id 23153525)1 Le Pogam C....Omidvar N. (Leuk. Res. 2013)
    535. Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways. (PubMed id 23316052)1 Ha J.H....Chi S.W. (J. Biol. Chem. 2013)
    536. Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma. (PubMed id 23479508)1 Tano T....Hamakawa H. (Neoplasia 2013)
    537. Epigenetic silencing of Bcl-2, CEBPA and p14(ARF) by the AML1-ETO oncoprotein contributing to growth arrest and differentiation block in the U937 cell line. (PubMed id 23673926)1 Zhuang W.Y....Chen Z.X. (Oncol. Rep. 2013)
    538. No compensation in CD44 stem cell marker following BCL-2 suppression by antisense oligonucleotides. (PubMed id 23422486)1 Rubenstein M....Guinan P. (In Vivo 2013)
    539. Melatonin is involved in the apoptosis and necrosis of pancreatic cancer cell line SW-1990 via modulating of Bcl-2/Bax balance. (PubMed id 23245210)1 Xu C....Shen J. (amp 2013)
    540. Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells. (PubMed id 23624503)1 Wu S....Chen Y. (Biochem. Biophys. Res. Commun. 2013)
    541. Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. (PubMed id 21618512)1 Rouette A....Asselin E. (Int. J. Cancer 2012)
    542. Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-I_B-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression. (PubMed id 21682651)1 Pratheeshkumar P....Kuttan G. (Immunopharmacol Immunotoxicol 2012)
    543. Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. (PubMed id 23568006)1 Zhang C....Zeng B. (Cancer Biomark 2012)
    544. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PubMed id 23055042)2 Zhang X.... Tang H. (Protein Cell 2012)
    545. Impact of single-nucleotide polymorphisms at the TP53-binding and responsive promoter region of BCL2 gene in modulating the phenotypic variability of LGMD2C patients. (PubMed id 22367371)1 Hadj Salem I....Fakhfakh F. (Mol. Biol. Rep. 2012)
    546. Estrogen receptor-regulated microRNAs contribute to the BCL2/BAX imbalance in endometrial adenocarcinoma and precancerous lesions. (PubMed id 22014978)1 Zhang R....Wei Z. (Cancer Lett. 2012)
    547. Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells. (PubMed id 22797576)1 Kunze D....Fuessel S. (Int. J. Oncol. 2012)
    548. Increased expression of hypoxia-inducible factor-1alpha and Bcl-2 in varicocele and varicose veins. (PubMed id 22749322)1 Lee J.D....Lee T.H. (Ann Vasc Surg 2012)
    549. Prognostic significance of Bcl-2, tumor-associated macrophages, and total neoplastic and inflammatory lymph node involvement in advanced stage classical Hodgkin's lymphoma. (PubMed id 23207618)1 Jakovic L.R....Bumbasirevic V.Z. (Onkologie 2012)
    550. Expression and mutation analyses of Fas, FLIP and Bcl-2 in granulosa cell tumor of ovary. (PubMed id 23235765)1 Yoo N.J....Lee S.H. (Tumori 2012)
    551. Gene expression patterns of the Bcl-2 and Bax genes in preterm birth. (PubMed id 22524261)1 Demendi C....JoA^ J.G. (Acta Obstet Gynecol Scand 2012)
    552. Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. (PubMed id 22065578)1 Zhao L....Chen Q. (J. Biol. Chem. 2012)
    553. Compensatory and non-compensatory effects on protein expression following BCL-2 suppression by antisense oligonucleotides. (PubMed id 22038727)1 Rubenstein M....Guinan P. (Med. Oncol. 2012)
    554. Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells. (PubMed id 22666341)1 Medan D....Rojanasakul Y. (PLoS ONE 2012)
    555. Antimycin A sensitizes cells to TRAIL-induced apoptosis through upregulation of DR5 and downregulation of c-FLIP and Bcl-2. (PubMed id 22842544)1 Lee S.J....Lee T.J. (Int. J. Oncol. 2012)
    556. The prognostic value of the immunohistochemical aspects of tumor suppressor genes p53, bcl-2, PTEN and nuclear proliferative antigen Ki-67 in resected colorectal carcinoma. (PubMed id 22990545)1 GhiALA8 C....Vasilescu F. (Rom J Morphol Embryol 2012)
    557. miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2. (PubMed id 22160209)1 Liu L....Wang X. (Mol Med Rep 2012)
    558. microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2. (PubMed id 22072615)1 Nie J....Han W. (Carcinogenesis 2012)
    559. [Expression and significance of bcl-2, bax and ER in foci of adenomyosis]. (PubMed id 23324193)1 Li B....Guo D. (Zhonghua Fu Chan Ke Za Zhi 2012)
    560. Expression and correlation of Bcl-2 with pathological grades in human glioma stem cells. (PubMed id 22562364)1 Qiu B....Wang Y. (Oncol. Rep. 2012)
    561. Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. (PubMed id 22851565)1 Johnson N.A....Gascoyne R.D. (J. Clin. Oncol. 2012)
    562. Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK). (PubMed id 22433870)1 Shajahan A.N....Clarke R. (J. Biol. Chem. 2012)
    563. Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression. (PubMed id 22081075)1 MAcrino D....Bouillet P. (Oncogene 2012)
    564. Evaluation of CD40, its ligand CD40L and Bcl-2 in psoriatic patients. (PubMed id 22532139)1 MyA9liwiec H....Chodynicka B. (Folia Histochem. Cytobiol. 2012)
    565. Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer. (PubMed id 21971866)1 Zhang Y....Wang Y.J. (Oncol. Rep. 2012)
    566. Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. (PubMed id 23091012)1 Geng X....Xue D. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    567. MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. (PubMed id 22207524)1 Wang X.F....You Y.P. (J. Cancer Res. Clin. Oncol. 2012)
    568. The -938A/A genotype of BCL2 gene is associated with esophageal cancer. (PubMed id 22187149)1 Liu Z....Lei G. (Med. Oncol. 2012)
    569. Clinical value of serum hepatocyte growth factor, B-cell lymphoma-2 and nitric oxide in primary breast cancer patients. (PubMed id 22953646)1 Ahmed H.H....Ramadan S.S. (Eur Rev Med Pharmacol Sci 2012)
    570. Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. (PubMed id 22965228)1 Sakurikar N....Chambers T.C. (J. Biol. Chem. 2012)
    571. The predictive role of Bcl-2 expression in operable locally advanced or metastatic gastric carcinoma. (PubMed id 22517702)1 Yildirim M....Sezer C. (J BUON 2012)
    572. No compensation in VEGF expression follows antisense suppression of BCL-2 activity. (PubMed id 23160675)1 Rubenstein M....Guinan P. (In Vivo 2012)
    573. Millimeter wave radiation induces apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 human chondrosarcoma cells. (PubMed id 22109662)1 Li X....Liu X. (Oncol. Rep. 2012)
    574. Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737. (PubMed id 22138435)1 Ishitsuka K....Tamura K. (Cancer Lett. 2012)
    575. Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells. (PubMed id 22504301)1 Choi H.J. and Han J.S. (Biochim. Biophys. Acta 2012)
    576. miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors. (PubMed id 22684875)1 Diniz M.G....Gomez R.S. (Cell Oncol (Dordr) 2012)
    577. Evaluation of apoptosis along with BCL-2 and Ki-67 expression in patients with intestinal metaplasia. (PubMed id 22277792)1 Erkan G....Dursun A. (Pathol. Res. Pract. 2012)
    578. Frequencies of BCL2 and BCL6 translocations in representative Chinese follicular lymphoma patients: morphologic, immunohistochemical, and FISH analyses. (PubMed id 22968395)1 Pan Y....Fu K. (Diagn. Mol. Pathol. 2012)
    579. Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. (PubMed id 22275372)1 Niture S.K. and Jaiswal A.K. (J. Biol. Chem. 2012)
    580. Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy. (PubMed id 22037714)1 Chauhan P.S....Kapur S. (Exp. Mol. Pathol. 2012)
    581. Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation. (PubMed id 22275374)1 Nambiar M. and Raghavan S.C. (J. Biol. Chem. 2012)
    582. Prognostic influence of BCL2 expression in breast cancer. (PubMed id 22418857)1 Hwang K.T....Noh D.Y. (Int. J. Cancer 2012)
    583. Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner. (PubMed id 22171982)1 Masood A....Chanan-Khan A. (Br. J. Haematol. 2012)
    584. Bcl-2 expression indicates better prognosis of Merkel cell carcinoma regardless of the presence of Merkel cell polyomavirus. (PubMed id 22976527)1 Sahi H....BAPhling T. (Virchows Arch. 2012)
    585. Sepia ink oligopeptide induces apoptosis in prostate cancer cell lines via caspase-3 activation and elevation of Bax/Bcl-2 ratio. (PubMed id 23170075)1 Huang F....Ding G. (Mar Drugs 2012)
    586. The correlation between IGF-II and Bcl-2 expression in colorectal adenocarcinoma. (PubMed id 21380782)1 Zhang M.S....Chen Y. (Med. Oncol. 2012)
    587. miR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2. (PubMed id 22285729)1 Li H....Xu W. (Acta Biochim. Biophys. Sin. (Shanghai) 2012)
    588. The effect of lentivirus-mediated expression of tumor necrosis factor related apoptosis-inducing ligand and shRNA against Bcl-2 on the growth of lymphoma cells. (PubMed id 21988644)1 Zhang X....Zhang M. (amp 2012)
    589. Artemin stimulates radio- and chemo-resistance by promoting TWIST1-BCL-2-dependent cancer stem cell-like behavior in mammary carcinoma cells. (PubMed id 23095743)1 Banerjee A....Lobie P.E. (J. Biol. Chem. 2012)
    590. S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy. (PubMed id 21971985)1 Yang L....Cao L. (Int. J. Mol. Med. 2012)
    591. Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. (PubMed id 22668799)7 Palayoor S.T....Coleman C.N. (J. Cardiovasc. Pharmacol. 2012)
    592. The clinicopathological significance of Bax and Bcl-2 protein expression with tumor infiltrating lymphocytes in ovarian carcinoma. (PubMed id 22668011)1 Yigit S....Cakalagaoglu F. (Neoplasma 2012)
    593. Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer. (PubMed id 22143931)1 Papagiorgis P.C....Nikiteas N.I. (Mol Med Rep 2012)
    594. High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis. (PubMed id 22804688)1 Kanagal-Shamanna R....Miranda R.N. (Histopathology 2012)
    595. B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome. (PubMed id 22002575)1 Li S....Medeiros L.J. (Mod. Pathol. 2012)
    596. Growing importance of MYC/BCL2 immunohistochemistry in diffuse large B-cell lymphomas. (PubMed id 22949148)1 Pfreundschuh M. (J. Clin. Oncol. 2012)
    597. Loss of soluble N-ethylmaleimide-sensitive factor attachment protein I+ (I+SNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi. (PubMed id 22194596)1 Naydenov N.G....Ivanov A.I. (J. Biol. Chem. 2012)
    598. Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. (PubMed id 21717192)1 Liang C.Z....Tao H.M. (Cancer Chemother. Pharmacol. 2012)
    599. [The expression and correlation of inducible nitric oxide synthase, Bax and Bcl-2 in nasal polyps]. (PubMed id 22675938)1 Liu Y....Wu W. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2012)
    600. Hypoxia-induced vasculogenic mimicry formation via VE-cadherin regulation by Bcl-2. (PubMed id 22562824)1 Zhao N....Gu Q. (Med. Oncol. 2012)
    601. Prognostic relevance of Bcl-2 overexpression in surgically treated prostate cancer is not caused by increased copy number or translocation of the gene. (PubMed id 22024950)1 Fleischmann A....Schlomm T. (Prostate 2012)
    602. Role of Caspase 8, Caspase 9 and Bcl-2 polymorphisms in papillary thyroid carcinoma risk in Han Chinese population. (PubMed id 22120515)1 Wang Y.X....Yu S.G. (Med. Oncol. 2012)
    603. Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia. (PubMed id 22393362)1 HAPgstrand K....Grandien A. (PLoS ONE 2012)
    604. Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. (PubMed id 22951829)1 Li Y....Wu J. (J. Virol. 2012)
    605. miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer. (PubMed id 23152059)1 Sacconi A....Blandino G. (amp 2012)
    606. Caspase-3/caspase-8, bax and bcl2 in pulps of human primary teeth with physiological root resorption. (PubMed id 21819468)1 Rodrigues L.V....Vasconcelos A.C. (Int J Paediatr Dent 2012)
    607. HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression. (PubMed id 22896703)1 Moon S.M....Ahn S.G. (J. Biol. Chem. 2012)
    608. Molecular characterization of apoptosis by the immunohistochemical evaluation of Bcl-2 in breast cancer. (PubMed id 22395515)1 Zaha D.C. and LazA8r E. (Rom J Morphol Embryol 2012)
    609. Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. (PubMed id 21890444)1 Wu X....Zhu Y.B. (Cancer Epidemiol 2012)
    610. Endoplasmic reticulum-specific BH3-only protein BNIP1 induces mitochondrial fragmentation in a Bcl-2- and Drp1-dependent manner. (PubMed id 22020994)1 Ryu S.W....Choi C. (J. Cell. Physiol. 2012)
    611. Etoposide induces a mixed type of programmed cell death and overcomes the resistance conferred by Bcl-2 in Hep3B hepatoma cells. (PubMed id 22895528)1 Yoo S.H....Yoo Y.H. (Int. J. Oncol. 2012)
    612. Soy isoflavones genistein and daidzein exert anti-apoptotic actions via a selective ER-mediated mechanism in neurons following HIV-1 Tat(1-86) exposure. (PubMed id 22629415)1 Adams S.M....Booze R.M. (PLoS ONE 2012)
    613. Clinicopathological significance of PTEN and bcl2 expressions in oral squamous cell carcinoma. (PubMed id 23119114)1 Rahmani A....Elkarimahmad H.G. (Int J Clin Exp Pathol 2012)
    614. EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis in gastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways. (PubMed id 22366766)1 Lv X.G....Fang C. (Mol Med Rep 2012)
    615. Biomarkers of progestin therapy resistance and endometrial hyperplasia progression. (PubMed id 22727345)1 Upson K....Garcia R.L. (Am. J. Obstet. Gynecol. 2012)
    616. BCL2 expression in CD105 positive neoangiogenic cells and tumor progression in angioimmunoblastic T-cell lymphoma. (PubMed id 22322190)1 Ratajczak P....Janin A. (Mod. Pathol. 2012)
    617. The use of an immunocytochemical double-labeling staining can display the distribution of Bcl-2/Ki-67 cells in endometrial adenocarcinomas as well as in normal endometrium. (PubMed id 22372356)1 Mourtzikou A....Karakitsos P. (Clin. Lab. 2012)
    618. BCL2 mutations in diffuse large B-cell lymphoma. (PubMed id 22189900)1 Schuetz J.M....Gascoyne R.D. (Leukemia 2012)
    619. Variation in BCL2 protein expression in follicular lymphomas without t(14;18) chromosomal translocations. (PubMed id 22406486)1 Masir N....Mason D.Y. (Pathology 2012)
    620. MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression. (PubMed id 22293115)1 Zhao A....Pei X. (J Genet Genomics 2012)
    621. Malondialdehyde, Bcl-2, superoxide dismutase and glutathione peroxidase may mediate the association of sonic hedgehog protein and oxidative stress in autism. (PubMed id 22143957)1 Ghanizadeh A. (Neurochem. Res. 2012)
    622. Prognostic significance of Bcl-2 in invasive mammary carcinomas: a comparative clinicopathologic study between &quot;triple-negative&quot; and non-&quot;triple-negative&quot; tumors. (PubMed id 21777944)1 Tawfik K....Tawfik O. (Hum. Pathol. 2012)
    623. The natively disordered loop of Bcl-2 undergoes phosphorylation-dependent conformational change and interacts with Pin1. (PubMed id 23272207)1 Kang C....Yoon H.S. (PLoS ONE 2012)
    624. Autocrine TNF is critical for the survival of human dendritic cells by regulating BAK, BCL-2, and FLIPL. (PubMed id 22504646)1 Lehner M....Holter W. (J. Immunol. 2012)
    625. Molecular and immunohistochemical characterization of B-cell lymphoma-2-negative follicular lymphomas. (PubMed id 21855110)1 Hoeller S....Dirnhofer S. (Hum. Pathol. 2012)
    626. Inactivation of Bcl-2 through II_B kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE). (PubMed id 22262057)1 Bodur C....Basaga H. (J. Cell. Physiol. 2012)
    627. Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapy. (PubMed id 22971934)1 Yang H....Zhao R.Y. (amp 2012)
    628. Src, Akt, NF-I_B, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia. (PubMed id 22591684)1 VA!zquez-Franco J.E....Lezama R.A. (Leuk. Res. 2012)
    629. BCL2 genetic variants are associated with acute kidney injury in septic shock*. (PubMed id 22710204)1 Frank A.J....Christiani D.C. (Crit. Care Med. 2012)
    630. Bortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple myeloma. (PubMed id 22054286)1 Ailawadhi S....Chanan-Khan A. (amp 2012)
    631. Expression profile of apoptosis-related genes in childhood adrenocortical tumors: low level of expression of BCL2 and TNF genes suggests a poor prognosis. (PubMed id 22619347)1 Lorea C.F....Scrideli C.A. (Eur. J. Endocrinol. 2012)
    632. CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway. (PubMed id 22563025)1 Li M.Q....Li D.J. (Hum. Reprod. 2012)
    633. The role of survivin and Bcl-2 in zinc-induced apoptosis in prostate cancer cells. (PubMed id 20822926)1 Ku J.H....Kim H.H. (Urol. Oncol. 2012)
    634. E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2. (PubMed id 21989054)1 Ferreira A.C....Machado J.C. (Hum. Mol. Genet. 2012)
    635. miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. (PubMed id 21258880)1 Zhu W....Liu P. (Med. Oncol. 2012)
    636. Clusterin confers resistance to TNF-alpha-induced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression. (PubMed id 23174100)1 Wang Y....Du Q. (J Chemother 2012)
    637. The expression and significance of MRP1, LRP, TOPOIII^, and BCL2 in tongue squamous cell carcinoma. (PubMed id 21793937)1 Zhang B....Huang H.Z. (amp 2012)
    638. MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2. (PubMed id 22967897)1 Yang Y....Li M. (FEBS Lett. 2012)
    639. Immunologic and cytogenetic markers expressed in non-Hodgkin lymphoma of head and neck. (PubMed id 22395507)1 Grigore R....MogoantA8 C.A. (Rom J Morphol Embryol 2012)
    640. Prognostic value of Bcl-2 in two independent populations of estrogen receptor positive breast cancer patients treated with adjuvant endocrine therapy. (PubMed id 22462654)1 Larsen M.S....LA ( 2012)
    641. Is the immunohistochemical expression of proliferation (Ki-67) and apoptosis (Bcl-2) markers and cyclooxigenase-2 (COX-2) related to carcinogenesis in postmenopausal endometrial polyps? (PubMed id 23301386)1 Antunes A....Costa-Paiva L. (Anal. Quant. Cytol. Histol. 2012)
    642. Bcl-2 inhibitors: emerging drugs in cancer therapy. (PubMed id 22414090)1 Bodur C. and Basaga H. (Curr. Med. Chem. 2012)
    643. Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage. (PubMed id 22622204)1 Han J....Li X.J. (Autophagy 2012)
    644. Influence of survivin and Bcl-2 expression on the biological behavior of non-small cell lung cancer. (PubMed id 22446832)1 Gao Q....Kang M.Q. (Mol Med Rep 2012)
    645. P53, Bcl-2 and Ki67 immunoexpression in follicular solid ameloblastomas. (PubMed id 22395508)1 Florescu A....Pitru A. (Rom J Morphol Embryol 2012)
    646. The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop. (PubMed id 22523079)1 Haupt K....LA1cke C. (J. Biol. Chem. 2012)
    647. The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells. (PubMed id 22647378)1 Genovese G....Sgambato A. (Cell Cycle 2012)
    648. Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement. (PubMed id 22855608)1 Louissaint A....Hasserjian R.P. (Blood 2012)
    649. Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. (PubMed id 22464442)1 Aranovich A....Andrews D.W. (Mol. Cell 2012)
    650. Study of molecular prognostic factors Bcl-2 and EGFR in rectal mucinous carcinomas. (PubMed id 22732796)1 Afrem G....CrA8iALoiu S. (Rom J Morphol Embryol 2012)
    651. miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. (PubMed id 22139839)1 Willimott S. and Wagner S.D. (J. Biol. Chem. 2012)
    652. Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK). (PubMed id 22506026)1 PlAPtz M....Eberle J. (PLoS ONE 2012)
    653. ATF5 is overexpressed in epithelial ovarian carcinomas and interference with its function increases apoptosis through the downregulation of Bcl-2 in SKOV-3 cells. (PubMed id 23018213)1 Chen A....Liu D.X. (Int. J. Gynecol. Pathol. 2012)
    654. Diffuse swelling of the buccal mucosa and palate as first and only manifestation of an extranodal non-Hodgkin 'double-hit' lymphoma: report of a case. (PubMed id 20981461)1 Frei M....Bornstein M.M. (Oral Maxillofac Surg 2012)
    655. Astragaloside IV prevents MPPa8_-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production. (PubMed id 22278385)1 Zhang Z.G....Gao G.D. (Mol. Cell. Biochem. 2012)
    656. Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma. (PubMed id 21936874)1 Tarquinio S.B....NAPr J.E. (amp 2012)
    657. Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. (PubMed id 22848417)1 Yan D....Tu L. (PLoS ONE 2012)
    658. Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors. (PubMed id 22995373)1 Ozer H....Cetin A. (Diagn Pathol 2012)
    659. Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth. (PubMed id 22366560)1 Lamers F....Molenaar J.J. (Eur. J. Cancer 2012)
    660. Association of BCL-2 polymorphism with the presence and severity of lumbar disc degeneration in the Chinese Han population. (PubMed id 22582499)1 Shang X.P....Ju B.B. (Clin. Lab. 2012)
    661. [The expressions and correlation of bcl-2 and Beclin-1 in pancreatic cancer]. (PubMed id 22650021)1 Cao S.S....He Z.P. (Sichuan Da Xue Xue Bao Yi Xue Ban 2012)
    662. [Effect of clofarabine on proliferation and Bcl-2 expression of NB4 cells]. (PubMed id 22739157)1 Liu H.B....He P.C. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2012)
    663. [Evaluating the activity of the apoptosis-regulating genes from Bcl-2, Bax expression, and caspase-3 activity in bronchial epithelial cells in patients with asthma]. (PubMed id 21506333)1 Mineev V.N....Grozov R.V. (Arkh. Patol. 2011)
    664. Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway. (PubMed id 21680733)1 Imanishi Y....Cheng S.Y. (J. Biol. Chem. 2011)
    665. Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells. (PubMed id 21442307)1 Skommer J....Raychaudhuri S. (Apoptosis 2011)
    666. Expression of apoptotic factors in vaginal tissues from women with urogenital prolapse. (PubMed id 21674599)1 Wen Y....Chen B. (Neurourol. Urodyn. 2011)
    667. Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi. (PubMed id 21669575)1 Lu Y....Lu Z.Q. (amp 2011)
    668. Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro. (PubMed id 21940310)1 Wu J.Y....Guo C.Y. (Hepatogastroenterology 2011)
    669. Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells. (PubMed id 21454712)1 Smith A.J....Kaufmann S.H. (J. Biol. Chem. 2011)
    670. Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis. (PubMed id 20836993)1 Rudner J....Huber S.M. (Biochem. Pharmacol. 2011)
    671. Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. (PubMed id 21543763)1 Xu C....Chuang T.H. (FASEB J. 2011)
    672. Roles of BCL-2 and MDR1 expression in the efficacy of paclitaxel-based lung cancer chemoradiation. (PubMed id 21508398)1 MarA!z A....HideghActy K. (Anticancer Res. 2011)
    673. The natural diterpene ent-16I^-17I+-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2I+/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. (PubMed id 21850486)1 Morales A....Galindo-Castro I. (Apoptosis 2011)
    674. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. (PubMed id 21148306)1 Kazi A....Sebti S.M. (J. Biol. Chem. 2011)
    675. Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. (PubMed id 22174832)1 Madden D.T....Bredesen D.E. (PLoS ONE 2011)
    676. Cryptic IGH/BCL2 rearrangements with variant FISH patterns in follicular lymphoma. (PubMed id 20952062)1 BarA^ C....SolAc F. (Leuk. Res. 2011)
    677. Effects of BCL-2 suppression by antisense oligonucleotides on additional regulators of apoptosis compensatory change in non-targeted protein expression. (PubMed id 21753125)1 Rubenstein M....Guinan P. (In Vivo 2011)
    678. Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects. (PubMed id 20399529)1 Malik M....Li X. (Immunobiology 2011)
    679. [Expression of Caspase-8 and Bcl-2 in the cartilage loose bodies in patients with Kashin-Beck disease]. (PubMed id 21868312)1 Wang Y....Wang S.J. (Nan Fang Yi Ke Da Xue Xue Bao 2011)
    680. Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by p53 and Bcl-2 family proteins. (PubMed id 21907236)1 Lee J.E....Koh H.C. (Neurotoxicology 2011)
    681. Bcl-2 and p53 expressions in Indian women with complete hydatidiform mole. (PubMed id 21808961)1 Rath G....Saxena S. (Singapore Med J 2011)
    682. Epidermal growth factor receptor (EGFR) abundance correlates with p53 and Bcl-2 accumulation and patient age in a small cohort of North African nasopharyngeal carcinoma patients. (PubMed id 21388911)1 Bourouba M....Touil-Boukoffa C. (Eur. Cytokine Netw. 2011)
    683. Genetic variation in BCL-2 and response to interferon in hepatitis C virus type 4 patients. (PubMed id 21159314)1 Shaker O.G....Abd-Rabou A.A. ( international journal of clinical chemistry 2011)
    684. Bcl2-A1 interacts with pro-caspase-3: implications for amyotrophic lateral sclerosis. (PubMed id 21624464)1 Iaccarino C....Crosio C. (Neurobiol. Dis. 2011)
    685. Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. (PubMed id 21060336)1 Ku B....Oh B.H. (Cell Res. 2011)
    686. CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI. (PubMed id 21448217)1 Wagner A.K....Fabio A. (J. Cereb. Blood Flow Metab. 2011)
    687. Regulatory BCL2 promoter polymorphism (-938C&gt;A) is associated with adverse outcome in patients with prostate carcinoma. (PubMed id 21207420)1 Bachmann H.S....Schulte J.H. (Int. J. Cancer 2011)
    688. Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease. (PubMed id 22219597)1 Tarantino G....Savastano S. (World J. Gastroenterol. 2011)
    689. Cytomorphologic findings of B-cell lymphomas with concurrent IGH/BCL2 and MYC rearrangements (dual-translocation lymphomas). (PubMed id 21560251)1 da Cunha Santos G....Geddie W.R. (Cancer Cytopathol 2011)
    690. Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation. (PubMed id 21778226)1 Geng F....Zhang Y. (J. Biol. Chem. 2011)
    691. H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERI+ ligand dependency. (PubMed id 21841772)1 Svotelis A....GAcvry N. (EMBO J. 2011)
    692. [Expression and significance of B cell-activating factor of TNF family (BAFF) and B cell lymphoma/leukemia-2 (BCL-2) in multiple myeloma]. (PubMed id 21518495)1 Wang S.M....Xing X.H. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011)
    693. Analysis of thermochemotherapy-induced apoptosis and the protein expressions of Bcl-2 and Bax in maxillofacial squamous cell carcinomas. (PubMed id 21104343)1 Zhao J....Mao Z.Y. (Med. Oncol. 2011)
    694. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. (PubMed id 20644561)1 Ho-Pun-Cheung A....Lopez-Crapez E. (Pharmacogenomics J. 2011)
    695. Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia. (PubMed id 21130495)1 Zhu D.X....Li J.Y. (Leuk. Res. 2011)
    696. The prognostic significance of the immunohistochemical expression of P53 and BCL-2 in endometrial cancer. (PubMed id 22252757)1 Dobrzycka B....Kulikowski M. (Folia Histochem. Cytobiol. 2011)
    697. Bcl-2 promotes malignant progression in a PDGF-B-dependent murine model of oligodendroglioma. (PubMed id 21171016)1 Doucette T....Rao G. (Int. J. Cancer 2011)
    698. p53 and BCL-2 over-expression inversely correlates with histological differentiation in occupational ethmoidal intestinal-type sinonasal adenocarcinoma. (PubMed id 21978692)1 Re M....Lo Muzio L. (Int J Immunopathol Pharmacol 2011)
    699. Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). (PubMed id 21622563)1 Zhou H....Lee A.S. (J. Biol. Chem. 2011)
    700. Bcl-2 is a better therapeutic target than c-Myc, but attacking both could be a more effective treatment strategy for B-cell lymphoma with concurrentA Bcl-2 and c-Myc overexpression. (PubMed id 21640157)1 Sasaki N....Taniwaki M. (Exp. Hematol. 2011)
    701. Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells. (PubMed id 21289092)1 Villeneuve C....Larminat F. (Mol. Biol. Cell 2011)
    702. PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway. (PubMed id 21385902)1 Zhang D....Li L. (Cancer Res. 2011)
    703. Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC). (PubMed id 20401641)1 Yang Y....Hou M. (Med. Oncol. 2011)
    704. Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia. (PubMed id 21317312)1 Mebratu Y.A....Tesfaigzi Y. (Am. J. Respir. Crit. Care Med. 2011)
    705. Alterations of p53 and Bcl-2 protein expression in the recurrent laryngeal and pharyngeal squamous cell carcinoma. (PubMed id 20434805)1 Rashad U.M....Algizawy S.M. (Am J Otolaryngol 2011)
    706. Immunohistochemical nuclear staining for p53, PCNA, Ki-67 and bcl-2 in different histologic variants of basal cell carcinoma. (PubMed id 21424069)1 Mateoiu C....Bogdan F. (Rom J Morphol Embryol 2011)
    707. High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. (PubMed id 20668868)1 Gan X.L....Hu L.N. (Arch. Gynecol. Obstet. 2011)
    708. [Apoptosis-inducing effect of clostridium difficile toxin A on K562 cells and its mechanism]. (PubMed id 21729540)1 Li P....Deng W. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011)
    709. miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention. (PubMed id 21463514)1 Srivastava N....Bamezai R.N. (Breast Cancer Res. 2011)
    710. Cytopathology of &quot;double-hit&quot; non-Hodgkin lymphoma. (PubMed id 21560252)1 Elkins C.T. and Wakely P.E. (Cancer Cytopathol 2011)
    711. Bcl-2 expression and triple negative profile in breast carcinoma. (PubMed id 20890735)1 Kallel-Bayoudh I....RebaA^ A. (Med. Oncol. 2011)
    712. [Mechanism and clinical significance of anti-apoptotic gene bcl-2 expression in diffuse large B-cell lymphoma]. (PubMed id 21914345)1 Zeng L.P....Zhang X.M. (Zhonghua Bing Li Xue Za Zhi 2011)
    713. Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation. (PubMed id 21589877)1 Oliver L....Vallette F.M. (PLoS ONE 2011)
    714. Single nucleotide polymorphisms in the p21 and bcl2 cancer susceptibility genes and breast cancer risk in Saudi Arabia. (PubMed id 22320961)1 Alshatwi A.A....Lei D.K. (Asian Pac. J. Cancer Prev. 2011)
    715. Synergistic effect of IFN-I^ gene on LIGHT-induced apoptosis in HepG2 cells via down regulation of Bcl-2. (PubMed id 21117871)1 Han B....Yong S. (Artif Cells Blood Substit Immobil Biotechnol 2011)
    716. Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells. (PubMed id 21376256)1 Dong J....Chen G. (Arch. Med. Res. 2011)
    717. Down-regulation of Bcl-2 is mediated by NF-I_B activation in Helicobacter pylori-induced apoptosis of gastric epithelial cells. (PubMed id 20969490)1 Chu S.H....Kim H. (Scand. J. Gastroenterol. 2011)
    718. The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells. (PubMed id 21151158)1 Yin J....Cao Y.J. (Acta Pharmacol. Sin. 2011)
    719. [Expression and clinical significance of COX-2 and BCL-2 in distal transitional mucosa adjacent to rectal carcinoma]. (PubMed id 21713707)1 Zhou D.F....Cui L. (Zhonghua Wei Chang Wai Ke Za Zhi 2011)
    720. Pathology, pathogenesis and molecular genetics of follicular NHL. (PubMed id 21658611)1 Leich E....Rosenwald A. (amp 2011)
    721. Upregulation of cellular Bcl-2 by the KSHV encoded RTA promotes virion production. (PubMed id 21901143)1 Gao J....Robertson E.S. (PLoS ONE 2011)
    722. P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. (PubMed id 21336967)1 Tsang T.Y....Kwok T.T. (Apoptosis 2011)
    723. Mitochondrial UCP4 and bcl-2 expression in imprints of breast carcinomas: relationship with DNA ploidy and classical prognostic factors. (PubMed id 21621926)1 Gonidi M....Athanassiadou P. (Pathol. Res. Pract. 2011)
    724. Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways. (PubMed id 21949016)1 Szymczak-Workman A.L....Vignali D.A. (J. Immunol. 2011)
    725. HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. (PubMed id 21956116)1 Chang J.R....Sawaya B.E. (J. Biol. Chem. 2011)
    726. Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells. (PubMed id 21233846)1 Trisciuoglio D....Del Bufalo D. (Cell Death Differ. 2011)
    727. BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. (PubMed id 21212266)1 Dluzen D....Liu D.X. (J. Biol. Chem. 2011)
    728. BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab. (PubMed id 21933893)1 Iqbal J....Chan W.C. (Clin. Cancer Res. 2011)
    729. Bcl-2-interacting mediator of cell death influences autoantigen-driven deletion and TCR revision. (PubMed id 21148799)1 Hale J.S....Fink P.J. (J. Immunol. 2011)
    730. BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization. (PubMed id 20716950)1 Ke H....French J.E. (amp 2011)
    731. Hypoxic human cancer cells are sensitized to BH-3 mimetica89induced apoptosis via downregulation of the Bcl-2 protein Mcl-1. (PubMed id 21393866)1 Harrison L.R....Dive C. (J. Clin. Invest. 2011)
    732. miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2. (PubMed id 21878650)1 Yadav S....Parmar D. (J. Biol. Chem. 2011)
    733. Effect of L-arginine on the expression of Bcl-2 and Bax in the placenta of fetal growth restriction. (PubMed id 21067292)1 Shen S.F. and Hua C.H. (amp 2011)
    734. PKCIP mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. (PubMed id 21624955)1 Heo K.S....Abe J. (J. Cell Biol. 2011)
    735. A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases. (PubMed id 21483469)1 Malik S....Seth P. (PLoS ONE 2011)
    736. Expression of cell proliferation and apoptosis biomarkers in pterygia and normal conjunctiva. (PubMed id 21738398)1 Liang K....Tao L.M. (Mol. Vis. 2011)
    737. MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. (PubMed id 21455217)1 Zhang H....Lai M. (Cell Death Differ. 2011)
    738. BCL-2 (-938C &gt; A) polymorphism is associated with breast cancer susceptibility. (PubMed id 21457555)1 Zhang N....Yang Q. (BMC Med. Genet. 2011)
    739. Bcl-2 targeted-therapy for the treatment of head and neck squamous cell carcinoma. (PubMed id 21110823)1 dos Santos L.V. and Carvalho A.L. (Recent Pat Anticancer Drug Discov 2011)
    740. Polymorphisms in the apoptotic pathway gene BCL-2 and survival in small cell lung cancer. (PubMed id 21107291)1 Knoefel L.F....Risch A. (J Thorac Oncol 2011)
    741. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression. (PubMed id 21640710)1 Qin B....Yang H. (Biochem. Biophys. Res. Commun. 2011)
    742. Mitogen-activated protein kinases mediate the production of B-cell lymphoma 2 protein by Mycobacterium tuberculosis in monocytes. (PubMed id 22022968)1 Natarajan P.L. and Narayanan S. (Biochemistry Mosc. 2011)
    743. Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. (PubMed id 21708043)1 Joshi S....Chircop M. (Mol. Cancer 2011)
    744. The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder. (PubMed id 21167476)1 Machado-Vieira R....Andrews S.B. (Biol. Psychiatry 2011)
    745. Reliability of the 34I^E12, keratin 5/6, p63, bcl-2, and AMACR in the diagnosis of prostate carcinoma. (PubMed id 20189848)1 Boran C....Akyol M. (Urol. Oncol. 2011)
    746. The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. (PubMed id 22152474)1 Rubinstein A.D....Kimchi A. (Mol. Cell 2011)
    747. Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis. (PubMed id 20885445)1 Oh S....Liang C. (Cell Death Differ. 2011)
    748. Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members. (PubMed id 21068757)1 Papadakis E.S....O'Toole E.A. (J. Invest. Dermatol. 2011)
    749. Dual targeting of Bcl-2 and VEGF: a potential strategy to improve therapy for prostate cancer. (PubMed id 19576799)1 Anai S....Rosser C.J. (Urol. Oncol. 2011)
    750. C-T variant in a miRNA target site of BCL2 is associated with increased risk of human papilloma virus related cervical cancer--an in silico approach. (PubMed id 21704150)1 Reshmi G....Pillai M.R. (Genomics 2011)
    751. Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy. (PubMed id 21199860)1 Davies J.E. and Rubinsztein D.C. (Hum. Mol. Genet. 2011)
    752. Expression of the apoptosis-related genes Bcl-2 and p53 in clinical samples from endometrial carcinoma patients. (PubMed id 22199279)1 GonzA!lez-Rodilla I....Schneider J. (Anticancer Res. 2011)
    753. Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: a study of hepatocellular carcinoma. (PubMed id 21748764)1 Sun T....Liu Z.Y. (Hepatology 2011)
    754. Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells. (PubMed id 20683843)1 Zhang Y....He L. (Phytother Res 2011)
    755. A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1. (PubMed id 20503275)1 Zhang Z....Du G. (Int. J. Cancer 2011)
    756. Quantitative expression analysis of apoptotic/antiapoptotic genes and association with immunolocalization of BAX and BCL-2 in peripheral and central giant cell lesions of the jaws. (PubMed id 21706237)1 Amaral F.R....Gomes C.C. (Tumour Biol. 2011)
    757. INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis. (PubMed id 20865015)1 Niture S.K. and Jaiswal A.K. (Cell Death Differ. 2011)
    758. Quantitative methylation analysis of BCL2, hTERT, and DAPK promoters in urine sediment for the detection of non-muscle-invasive urothelial carcinoma of the bladder: a prospective, two-center validation study. (PubMed id 19272801)1 Vinci S....Orlando C. (Urol. Oncol. 2011)
    759. [Study on EB virus infection, LMP1 and Bcl-2 expression in lung cancer patients]. (PubMed id 22097606)1 Li C.M....Han G.L. (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2011)
    760. A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding. (PubMed id 20140889)1 Maestre-MartA-nez M....LA1cke C. (J. Mol. Recognit. 2011)
    761. Translocation t(14;18)/IGH-BCL2 in gastrointestinal follicular lymphoma: correlation with clinicopathologic features in 48 patients. (PubMed id 24048795)1 Yanai S....Matsumoto T. (Cancer 2011)
    762. Pokemon reduces Bcl-2 expression through NF-I_ Bp65: A possible mechanism of hepatocellular carcinoma. (PubMed id 21771706)1 Zhao X....Tian D. (Asian Pac J Trop Med 2011)
    763. Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells. (PubMed id 21659544)1 Morales A.A....Boise L.H. (Blood 2011)
    764. IRGM is a common target of RNA viruses that subvert the autophagy network. (PubMed id 22174682)1 Gregoire I.P.... Faure M. (PLoS Pathog. 2011)
    765. E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53. (PubMed id 21597459)1 Jung J.H....Lee J.H. (Cell Death Differ. 2011)
    766. EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. (PubMed id 22194861)1 Ryan R.J....Le L.P. (PLoS ONE 2011)
    767. The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with Bcl-2 in non-small cell lung cancer. (PubMed id 21748337)1 Chen S....Chen H. (Mol. Cell. Biochem. 2011)
    768. The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity. (PubMed id 21474673)1 Velaithan R....Pervaiz S. (Blood 2011)
    769. BCL2 and MYC dual-hit lymphoma/leukemia. (PubMed id 21628855)1 Tomita N. (J Clin Exp Hematop 2011)
    770. Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder. (PubMed id 21320251)1 Uemura T....Warsh J.J. (Bipolar Disord 2011)
    771. Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an exploratory study. (PubMed id 20962079)1 Dillon S.M....Wilson C.C. (J. Virol. 2011)
    772. The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells. (PubMed id 21785112)1 Wang K....Shen Q. (Acta Biochim. Biophys. Sin. (Shanghai) 2011)
    773. A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1. (PubMed id 21412927)1 TA1rkmen S....Burmeister T. (amp 2011)
    774. Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features. (PubMed id 22038216)1 Wang F....Zhang X.S. (Folia Histochem. Cytobiol. 2011)
    775. Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. (PubMed id 21358617)1 Strappazzon F....Cecconi F. (EMBO J. 2011)
    776. Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes. (PubMed id 21444675)1 Laulier C....Lopez B.S. (Cancer Res. 2011)
    777. An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737. (PubMed id 21772052)1 Al-Harbi S....Almasan A. (Blood 2011)
    778. Association of the CC genotype of the regulatory BCL2 promoter polymorphism (-938C&gt;A) with better 2-year survival in patients with glioblastoma multiforme. (PubMed id 21250804)1 El Hindy N....Sandalcioglu I.E. (J. Neurosurg. 2011)
    779. Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors. (PubMed id 22309998)1 Moschovi M....Alexiou G.A. (Pediatr Neurosurg 2011)
    780. The significance of expression of autophagy-related gene Beclin, Bcl-2, and Bax in breast cancer tissues. (PubMed id 21861179)1 Yao Q....Wang L. (Tumour Biol. 2011)
    781. Co-overexpression of bcl-2 and c-myc in uterine cervix carcinomas and premalignant lesions. (PubMed id 21556123)1 Protrka Z....Djuric J. (Eur J Histochem 2011)
    782. Investigation of the Bcl-2 multimerisation process: structural and functional implications. (PubMed id 21320534)1 Camperchioli A....Fattorusso C. (Biochim. Biophys. Acta 2011)
    783. RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor. (PubMed id 21174060)1 Tseng H.H....Yiang G.T. (Oncol. Rep. 2011)
    784. Ovarian serous carcinoma: relationship of p53 and bcl-2 with tumor angiogenesis and VEGF expression. (PubMed id 21979585)1 Crasta J.A....Vallikad E. (Int. J. Gynecol. Pathol. 2011)
    785. Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells. (PubMed id 20652449)1 Zhou F.F....Xia L.P. (Med. Oncol. 2011)
    786. The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors. (PubMed id 21072044)1 de Boer J....Brady H.J. (Leukemia 2011)
    787. Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity. (PubMed id 20691103)1 Yu B....Sun Z.J. (amp 2010)
    788. Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. (PubMed id 21203533)1 Vento M.T....Iaccarino I. (PLoS ONE 2010)
    789. Small molecules regulating apoptosis in the synovium in rheumatoid arthritis. (PubMed id 20936988)1 Dubikov A.I. and Kalinichenko S.G. (Scand. J. Rheumatol. 2010)
    790. Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores. (PubMed id 19925052)1 Tzankov A....Dirnhofer S. (amp 2010)
    791. Prognostic significance of CD95, P53, and BCL2 expression in extranodal non-Hodgkin's lymphoma. (PubMed id 20352431)1 Chatzitolios A....Papadopoulos N. (Ann. Hematol. 2010)
    792. Odontoblast-targeted Bcl-2 overexpression impairs dentin formation. (PubMed id 20518070)1 Zhang W....Gronowicz G. (J. Cell. Biochem. 2010)
    793. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    794. Coxiella burnetii modulates Beclin 1 and Bcl-2, preventing host cell apoptosis to generate a persistent bacterial infection. (PubMed id 19798108)1 VA!zquez C.L. and Colombo M.I. (Cell Death Differ. 2010)
    795. Altered expression of apoptosis biomarkers in human colorectal microadenomas. (PubMed id 20142237)1 Sena P....De Pol A. (amp 2010)
    796. Relationship between apoptotic markers (Bax and Bcl-2) and biochemical markers in type 2 diabetes mellitus. (PubMed id 20200776)1 Hasnan J....Norbaini T.H. (Singapore Med J 2010)
    797. [Different regulation of mitochondrial apoptosis and Bcl-2 gene expression in quescent and proliferative human fibroblasts infected with cytomegalovirus]. (PubMed id 20352700)1 Fedorova N.E....Kushch A.A. (Tsitologiia 2010)
    798. ER-I^ mediates 17I^-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling. (PubMed id 20340172)1 Adams S.M....Booze R.M. (Synapse 2010)
    799. B1, a novel amonafide analogue, overcomes the resistance conferred by Bcl-2 in human promyelocytic leukemia HL60 cells. (PubMed id 21076048)1 Liang X....Qian X. (Mol. Cancer Res. 2010)
    800. Bcl-2 overexpression in hepatic stellate cell line CFSC-2G, induces a pro-fibrotic state. (PubMed id 20594261)1 GonzA!lez-Puertos V.Y....Konigsberg M. (J. Gastroenterol. Hepatol. 2010)
    801. Fluorescence in situ hybridization analysis and immunophenotyping of c-Kit/PDGFRA and Bcl-2 expression in gastrointestinal stromal tumors. (PubMed id 21434524)1 Orsenigo M....Pilotti S. (Anal. Quant. Cytol. Histol. 2010)
    802. E2F1-directed activation of Bcl-2 is correlated with lactoferrin-induced apoptosis in Jurkat leukemia T lymphocytes. (PubMed id 20411301)1 Lee S.H....Choi S.Y. (Biometals 2010)
    803. Altered expression of cell cycle and apoptotic proteins in human liver pathologies. (PubMed id 21115898)1 Mitselou A....Agnantis N.J. (Anticancer Res. 2010)
    804. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. (PubMed id 20951945)1 Feng H....Look A.T. (Cancer Cell 2010)
    805. Correlation of cell cycle regulatory proteins (p53 and p16(ink)a8'(a)) and bcl-2 oncoprotein with mitotic index and thickness of primary cutaneous malignant melanoma. (PubMed id 21108607)1 Kostov M....JeliA8 M. (Bosn J Basic Med Sci 2010)
    806. Tumor necrosis is a new promising prognostic factor in colorectal cancer. (PubMed id 20869096)1 Pollheimer M.J....Langner C. (Hum. Pathol. 2010)
    807. Bispecific antisense oligonucleotides have activity comparable to monospecifics in inhibiting expression of BCL-2 in LNCaP cells. (PubMed id 20668314)1 Rubenstein M. and Guinan P. (In Vivo 2010)
    808. Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage. (PubMed id 20223826)1 Lopez H....Luo X. (J. Biol. Chem. 2010)
    809. Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells. (PubMed id 19556603)1 Azad N....Rojanasakul Y. (Am. J. Respir. Cell Mol. Biol. 2010)
    810. [Inhibitory effect of matrine on proliferation of human ovary malignant teratoma cell line PA-1 in vitro]. (PubMed id 20929131)1 Chen C.D....Zhang H.C. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2010)
    811. [Effect of bortezomib on lymphoma cell line CA46 and its relative mechanisms]. (PubMed id 20723300)1 Huang H.B....Wu S.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    812. Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease. (PubMed id 19774677)1 Sultana R....Butterfield D.A. (J. Neurosci. Res. 2010)
    813. Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation. (PubMed id 20716276)1 Azad N....Rojanasakul Y. (Ann. N. Y. Acad. Sci. 2010)
    814. [Effect of combined therapy with Chinese drug and narrow broad ultraviolet B on Bcl-2, caspase-3 and survivin in skin lesion with psoriasis vulgaris]. (PubMed id 20929126)1 Qin L.Y....Ye W.J. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2010)
    815. Bcl-2 overexpression in type II epithelial cells does not prevent hyperoxia-induced acute lung injury in mice. (PubMed id 20382751)1 MActrailler-Ruchonnet I....Barazzone C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010)
    816. Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci. (PubMed id 20495005)1 Tonic I....Hay N. (J. Biol. Chem. 2010)
    817. The possible role of Bcl-2 expression of tumors of the uterine cervix. (PubMed id 20658730)1 Protrka Z....ArsenijeviA8 S. (J BUON 2010)
    818. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    819. Spatial and temporal distribution of Ki-67 proliferation marker, Bcl-2 and Bax proteins in the developing human tooth. (PubMed id 20732674)1 KaliboviA8 Govorko D....Saraga-BabiA8 M. (Arch. Oral Biol. 2010)
    820. Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. (PubMed id 20668552)1 Trisciuoglio D....Del Bufalo D. (PLoS ONE 2010)
    821. Apoptosis and Bcl-2 protein expression in human placenta over the course of normal pregnancy. (PubMed id 20608924)1 Soni S....Jain A.K. (Anat Histol Embryol 2010)
    822. BCL-2/IgH polymerase chain reaction status at the end of induction treatment is not predictive for progression-free survival in relapsed/resistant follicular lymphoma: results of a prospective randomized EORTC 20981 phase III intergroup study. (PubMed id 20368567)1 van Oers M.H....van der Reijden B.A. (J. Clin. Oncol. 2010)
    823. Detection of B cell lymphoma 2, tumor protein 53, and FAS gene transcripts in blood cells of patients with breast cancer. (PubMed id 21131755)1 Jaberipour M....Ghaderi A. (Indian J Cancer 2010)
    824. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. (PubMed id 20460269)1 Pedrini S....Pasinelli P. (Hum. Mol. Genet. 2010)
    825. Expression of apoptotic markers BCL-2 and Bax in chronic hepatitis C virus patients. (PubMed id 20627094)1 Hanafy S.M....Farahat N.M. (Clin. Biochem. 2010)
    826. Molecular analysis of oral squamous cell carcinoma: a tissue microarray study. (PubMed id 20448381)1 Solomon M.C....Gudattu V. (Indian J Cancer 2010)
    827. Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. (PubMed id 19238538)1 Arisan E.D....Basaga H. (Breast Cancer Res. Treat. 2010)
    828. Poly (ADP-ribose) polymerase-1 binds to BCL2 major breakpoint region and regulates BCL2 expression. (PubMed id 20564216)1 Yang N....Sun Y. (J. Cell. Biochem. 2010)
    829. Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin- induced apoptosis in H9c2 cells. (PubMed id 20849813)2 Liu Y.... Chen Y.H. (Biochem. Biophys. Res. Commun. 2010)
    830. Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways. (PubMed id 20045442)1 Zhang Y.W....Zhao W.L. (Exp. Hematol. 2010)
    831. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. (PubMed id 20072652)1 Lin L....Lin J. (Neoplasia 2010)
    832. The relationship between bcl-2 oncogene expression and clinicopathological criteria in various stages of cervical neoplasia in Egyptian women. (PubMed id 21061795)1 Agur W....Abou-Senna I. (Eur. J. Gynaecol. Oncol. 2010)
    833. Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif. (PubMed id 20584903)1 Ding J....Lin J. (J. Biol. Chem. 2010)
    834. [Effects of di-(2-ethylexyl) phthalate on apoptosis of cytotrophoblasts in early pregnancy]. (PubMed id 21029589)1 Wang X....Wang L.M. (Zhonghua Fu Chan Ke Za Zhi 2010)
    835. Artemin-stimulated progression of human non-small cell lung carcinoma is mediated by BCL2. (PubMed id 20530713)1 Tang J.Z....Lobie P.E. (Mol. Cancer Ther. 2010)
    836. An immunohistochemical comparison of P53 and Bcl-2 as apoptotic and MIB1 as proliferative markers in low-grade and high-grade ovarian serous carcinomas. (PubMed id 20442586)1 Mishra S.K. and Crasta J.A. (Int. J. Gynecol. Cancer 2010)
    837. Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL. (PubMed id 20048149)1 Ma D....Jiang Y. (J. Biol. Chem. 2010)
    838. Ki-67 and Bcl-2 antigen expression in adenomatous colorectal polyps from women with breast cancer. (PubMed id 20177797)1 de Sousa-JA_nior E.C....da Silva B.B. (Ann. Surg. Oncol. 2010)
    839. Expressions of the anti-apoptotic genes Bag-1 and Bcl-2 in colon cancer and their relationship. (PubMed id 20409521)1 Sun N....Tian A. (Am. J. Surg. 2010)
    840. Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects. (PubMed id 19854241)1 Sheikh A.M....Malik M. (Neuroscience 2010)
    841. Bcl-2 expression in mycosis fungoides before and after PUVA therapy. (PubMed id 20415745)1 Weshahy H....Hindawi A. (amp 2010)
    842. Apoptotic regulation by MCL-1 through heterodimerization. (PubMed id 20392693)1 Liu Q....Gehring K. (J. Biol. Chem. 2010)
    843. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. (PubMed id 19676105)1 Watson J.L....Hoskin D.W. (Mol. Carcinog. 2010)
    844. Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells. (PubMed id 20841355)1 Launay N....Lilienbaum A. (J. Biol. Chem. 2010)
    845. Prognostic stratification of stage IIIA pN2 non-small cell lung cancer by hierarchical clustering analysis of tissue microarray immunostaining data: an Alpe Adria Thoracic Oncology Multidisciplinary Group study (ATOM 014). (PubMed id 20631638)1 Grossi F....Belvedere O. (J Thorac Oncol 2010)
    846. Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens. (PubMed id 20025478)1 Karamitopoulou E....Brunner T. (Pathology 2010)
    847. WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells. (PubMed id 19890377)1 Kang R....Cao L. (Leukemia 2010)
    848. Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells. (PubMed id 19937732)1 Chen K.C....Chang L.S. (J. Cell. Biochem. 2010)
    849. Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1). (PubMed id 20571027)1 Ishimaru D....Spicer E.K. (J. Biol. Chem. 2010)
    850. The proapoptotic molecule BLID interacts with Bcl-XL and its downregulation in breast cancer correlates with poor disease-free and overall survival. (PubMed id 20400521)1 Broustas C.G....Kasid U.N. (Clin. Cancer Res. 2010)
    851. Quantitative analysis of BCL2 mRNA expression in nasopharyngeal carcinoma: an unfavorable and independent prognostic factor. (PubMed id 20514538)1 Fendri A....Scorilas A. (Tumour Biol. 2010)
    852. [Proliferative inhibition and apoptotic induction effects of crocin on human leukemia HL-60 cells and their mechanisms]. (PubMed id 20723294)1 Xu H.J....Sun L.R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    853. Small interfering RNA targeting of Recepteur d'Origine Nantais induces apoptosis via modulation of nuclear factor-kappaB and Bcl-2 family in gastric cancer cells. (PubMed id 20664977)1 Park J.S....Jung Y.D. (Oncol. Rep. 2010)
    854. [Relevant study on apoptosis of cervical cancer HeLa cells induced by paeoniflorin]. (PubMed id 21223758)1 Zhang L.L....Wang S.Z. (Zhonghua Yi Xue Za Zhi 2010)
    855. Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. (PubMed id 20423464)1 Siganaki M....Tzortzaki E.G. (Respir. Res. 2010)
    856. [Effect of Kidney-Tonifying and Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in aged patients with kidney deficiency and blood stasis syndrome]. (PubMed id 20423844)1 Hu J....Lu J.Z. (Nan Fang Yi Ke Da Xue Xue Bao 2010)
    857. Study of the immunoexpression of Bcl-2 by a cutaneous granular cell tumor. (PubMed id 20976415)1 Fernandez-Flores A. and Valerdiz S. (Acta Dermatovenerol Alp Panonica Adriat 2010)
    858. Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy. (PubMed id 20181625)1 Holgersson G....BergstrAPm S. (amp 2010)
    859. Regulation of mitochondrial apoptotic events by p53-mediated disruption of complexes between antiapoptotic Bcl-2 members and Bim. (PubMed id 20404322)1 Han J....Rabinowich H. (J. Biol. Chem. 2010)
    860. [Expression of survivin, bcl-2 in cervical carcinoma and its association with HPV16/18 infection]. (PubMed id 20368071)1 Zhu H....Zhang H.X. (Zhonghua Yi Xue Za Zhi 2010)
    861. B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma. (PubMed id 20118770)1 Snuderl M....Sohani A.R. (Am. J. Surg. Pathol. 2010)
    862. Beclin 1 modulates the anti-apoptotic activity of Bcl-2: insights from a pathogen infection system. (PubMed id 20023428)1 VA!zquez C.L. and Colombo M.I. (Autophagy 2010)
    863. Anti-apoptotic protein BCL2 down-regulates DNA end joining in cancer cells. (PubMed id 20699221)1 Kumar T.S....Raghavan S.C. (J. Biol. Chem. 2010)
    864. BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. (PubMed id 20648653)1 Sheikh A.M....Li X. (J. Neurosci. Res. 2010)
    865. [Study on the apoptosis inducing effect of pseudolaric acid B on cervical carcinoma cell line HeLa cells]. (PubMed id 20929130)1 Hu Y....Hou L.H. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2010)
    866. [Effect of topical corticosteroids on expression of PKC, Bcl-2 and Bax in nasal polyps]. (PubMed id 21090097)1 Ren X....He Q. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010)
    867. Treatment of K562 cells with 1,25-dihydroxyvitamin D3 induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCLXL, and p21. (PubMed id 19475409)1 Kizildag S....Kizildag S. (Ann. Hematol. 2010)
    868. Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. (PubMed id 19786087)1 Park C....Choi Y.H. (Toxicol In Vitro 2010)
    869. Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax. (PubMed id 21122152)1 Wang P....Zhang X. (BMC Cancer 2010)
    870. Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia. (PubMed id 19452318)1 Jak M....Van Oers M.H. (amp 2009)
    871. Study of apoptosis and related proteins, CRH and hpGH in placentas of newborns small for gestational age (SGA). (PubMed id 19404232)1 Barrio E....LongA!s A.F. (Pediatr Endocrinol Rev 2009)
    872. Bcl-2 is an integral component of mitotic chromosomes. (PubMed id 19269343)1 Barboule N....Larminat F. (Cell Biol. Int. 2009)
    873. MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway. (PubMed id 19521340)1 Mancini F....Moretti F. (EMBO J. 2009)
    874. E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression. (PubMed id 18983973)1 Wang L....Zha X. (Arch. Biochem. Biophys. 2009)
    875. Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression. (PubMed id 19625133)1 Li-juan B....Ying-jie L. (Pathol. Res. Pract. 2009)
    876. p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. (PubMed id 19737931)1 Obexer P....Ausserlechner M.J. (J. Biol. Chem. 2009)
    877. Antiapoptotic proteins Bcl-2 and Bcl-XL inhibit Clostridium difficile toxin A-induced cell death in human epithelial cells. (PubMed id 19797069)1 Matte I....PichAc A. (Infect. Immun. 2009)
    878. Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2. (PubMed id 19706769)2 Welch C.... Green M.R. (Cancer Res. 2009)
    879. Up regulation of the GRP-78 and GADD-153 and down regulation of Bcl-2 proteins in primary glomerular diseases: a possible involvement of the ER stress pathway in glomerulonephritis. (PubMed id 19107326)1 Markan S....Khullar M. (Mol. Cell. Biochem. 2009)
    880. Bcl-2 regulates the onset of shiga toxin 1-induced apoptosis in THP-1 cells. (PubMed id 19752028)1 Lee M.S....Tesh V.L. (Infect. Immun. 2009)
    881. CD40 ligand, Bcl-2 and apoptosis in B-chronic lymphocytic leukemia. (PubMed id 22059351)1 Hussein O.A....Fathy A. (Egypt J Immunol 2009)
    882. p53, Bcl-2 and AgNOR tissue markers: model approach in predicting prostate cancer characteristics. (PubMed id 20146885)1 Munda M....Stiblar Martincic D. (J. Int. Med. Res. 2009)
    883. CD44+ cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast tumours. (PubMed id 19385591)1 Madjd Z....Asadi-Lari M. (Cancer Immun. 2009)
    884. IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. (PubMed id 19168699)1 Waxman A.B. and Kolliputi N. (Am. J. Respir. Cell Mol. Biol. 2009)
    885. Analysis of p53, BCL-2 and epidermal growth factor receptor protein expression in the partial and complete hydatidiform moles. (PubMed id 19348791)1 Hussein M.R. (Exp. Mol. Pathol. 2009)
    886. Bcl-2 but not FOXP1, is an adverse risk factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas. (PubMed id 19141121)1 Nyman H....LeppAo S. (Eur. J. Haematol. 2009)
    887. Over-expression of the anti-apoptotic protein Bcl-2 affects membrane lipid composition in HL-60 cells. (PubMed id 19280241)1 Cantrel C....Geny B. (Lipids 2009)
    888. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. (PubMed id 19250983)1 Yan F....Polk D.B. (Gastroenterology 2009)
    889. Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. (PubMed id 19723066)1 Thomadaki H....Scorilas A. (Ann. N. Y. Acad. Sci. 2009)
    890. The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern. (PubMed id 19908860)1 Kendrick S....Hurley L.H. (J. Am. Chem. Soc. 2009)
    891. Implications of Nef: host cell interactions in viral persistence and progression to AIDS. (PubMed id 20012528)1 Arhel N.J. and Kirchhoff F. (Curr. Top. Microbiol. Immunol. 2009)
    892. Oocyte in-vitro maturation: BCL2 mRNA content in cumulus cells reflects oocyte competency. (PubMed id 20034411)1 Filali M....Machelon V. (Reprod. Biomed. Online 2009)
    893. [An experimental study of bladder cancer cell apoptosis induced by cinobufacin]. (PubMed id 19351510)1 Su J....Ye M.S. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009)
    894. Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era. (PubMed id 19656156)1 Seki R....Okamura T. (Cancer Sci. 2009)
    895. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. (PubMed id 19597184)1 Johnson N.A....Horsman D.E. (Blood 2009)
    896. Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. (PubMed id 19395874)1 Zalckvar E....Kimchi A. (Autophagy 2009)
    897. Assessment of estrogen receptors and apoptotic factors in cryopreserved human ovarian cortex. (PubMed id 19938958)1 Depalo R....Lippolis C. (Syst Biol Reprod Med 2009)
    898. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    899. Spatial allelic imbalance of BCL2 genes and chromosome 18 territories in nonneoplastic and neoplastic cervical squamous epithelium. (PubMed id 19495739)1 Wiech T....Hausmann M. (Eur. Biophys. J. 2009)
    900. C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells. (PubMed id 19717648)1 Pal R....Lentzsch S. (Blood 2009)
    901. BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2. (PubMed id 20032416)1 Gollub W....Thorns C. (Anticancer Res. 2009)
    902. The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts. (PubMed id 19473442)1 Vered M....Buchner A. (amp 2009)
    903. Exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2/Bax pathway. (PubMed id 19360919)1 Yao Y....Song T.S. (World J. Gastroenterol. 2009)
    904. Prognostic impact of activated B-cell focused classification in diffuse large B-cell lymphoma patients treated with R-CHOP. (PubMed id 19448593)1 Nyman H....LeppAo S. (Mod. Pathol. 2009)
    905. BCL2 gene aberration as an IPI-independent marker for poor outcome in non-germinal-centre diffuse large B cell lymphoma. (PubMed id 19783718)1 Obermann E.C....Tzankov A. (J. Clin. Pathol. 2009)
    906. Why doesn't Beclin 1, a BH3-only protein, suppress the anti-apoptotic function of Bcl-2? (PubMed id 19535901)1 Ciechomska I.A....Tolkovsky A.M. (Autophagy 2009)
    907. [Effects of K237 on the proliferation of PC-3M cells and mRNA expressions of bax and bcl-2]. (PubMed id 20180421)1 Zhang Y.L....Hu N.G. (Zhonghua Nan Ke Xue 2009)
    908. Protective effect of magnolol against hydrogen peroxide-induced oxidative stress in human lens epithelial cells. (PubMed id 19655415)1 Yao K....Zhang Y.D. (Am. J. Chin. Med. 2009)
    909. hnRNP L binds to CA repeats in the 3'UTR of bcl-2 mRNA. (PubMed id 19298794)1 Lee D.H....Lee J.H. (Biochem. Biophys. Res. Commun. 2009)
    910. Expression of apoptosis-related proteins and of mRNA for dopaminergic receptors in peripheral blood mononuclear cells from patients with Alzheimer disease. (PubMed id 19266703)1 Cosentino M....Lecchini S. (Alzheimer Dis Assoc Disord 2009)
    911. The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2's pore-forming and anti-Bax activities in the membrane. (PubMed id 19813621)1 Peng J....Lin J. (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2009)
    912. Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. (PubMed id 19380879)1 Gallenne T....Juin P. (J. Cell Biol. 2009)
    913. B cell lymphoma (Bcl)-2 protein is the major determinant in bcl-2 adenine-uridine-rich element turnover overcoming HuR activity. (PubMed id 19520857)1 Ghisolfi L....Bevilacqua A. (J. Biol. Chem. 2009)
    914. The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. (PubMed id 19706527)1 Rong Y.P....Distelhorst C.W. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    915. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. (PubMed id 19549844)1 Saito M....Dalla-Favera R. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    916. Prognostic value of apoptosis-related markers in urothelial cancer of the upper urinary tract. (PubMed id 19157504)1 Jeong I.G....Lee E. (Hum. Pathol. 2009)
    917. Clinicopathological features of lymphoma/leukemia patients carrying both BCL2 and MYC translocations. (PubMed id 19535347)1 Tomita N....Miura I. (Haematologica 2009)
    918. Nongenomic effect of estrogen on the MAPK signaling pathway and calcium influx in endometrial carcinoma cells. (PubMed id 19160418)1 Zhang L....Wei L. (J. Cell. Biochem. 2009)
    919. Structural and functional similarity between the bacterial type III secretion system needle protein PrgI and the eukaryotic apoptosis Bcl-2 proteins. (PubMed id 19823588)1 Shortridge M.D. and Powers R. (PLoS ONE 2009)
    920. Prognostic significance of the Bcl-2 negative germinal centre in patients with diffuse large B cell lymphoma treated with R-CHOP. (PubMed id 19152170)1 Song M.K....Cho G.J. (amp 2009)
    921. A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. (PubMed id 18835031)1 Kolluri S.K....Zhang X.K. (Cancer Cell 2008)
    922. Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity. (PubMed id 18263880)1 Zhao J....Deng X. (J. Biol. Chem. 2008)
    923. Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. (PubMed id 18657507)1 Rong Y.P....Distelhorst C.W. (Mol. Cell 2008)
    924. MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type. (PubMed id 18752503)1 Yoon S.O....Kim C.W. (Histopathology 2008)
    925. Autophagy is activated, but is not required for the G0 function of BCL-2 or BCL-xL. (PubMed id 18758240)1 Valentin M. and Yang E. (Cell Cycle 2008)
    926. [Expression of survivin and its correlation with p53 and bcl-2 expression in laryngeal and hypopharyngeal cancer]. (PubMed id 18595518)1 Sun M. and Qin Y. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    927. The spliced variant of hepatitis B virus protein, HBSP, interacts with Bcl-2/Bcl-xl in vitro and induces apoptosis in HepG2 cells. (PubMed id 18543286)1 Lu Y.W....Chen W.N. (IUBMB Life 2008)
    928. Inhibition of receptor-mediated apoptosis upon Bcl-2 overexpression is not associated with increased antioxidant status. (PubMed id 18687309)1 Thomson S.J....Hampton M.B. (Biochem. Biophys. Res. Commun. 2008)
    929. Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel-resistant phenotype. (PubMed id 17893875)1 Solar P....Sytkowski A.J. (Int. J. Cancer 2008)
    930. CXCL12/CXCR4 signaling promotes human thymic dendritic cell survival regulating the Bcl-2/Bax ratio. (PubMed id 18692524)1 HernA!ndez-LA^pez C....Vicente A. (Immunol. Lett. 2008)
    931. Focal cortical dysplasia type II (malformations of cortical development) aberrantly expresses apoptotic proteins. (PubMed id 18594472)1 Chamberlain W.A. and Prayson R.A. (amp 2008)
    932. Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content. (PubMed id 18407350)1 Hanson C.J....Roderick H.L. (Cell Calcium 2008)
    933. Bcl2 negatively regulates DNA double-strand-break repair through a nonhomologous end-joining pathway. (PubMed id 18313386)1 Wang Q....Deng X. (Mol. Cell 2008)
    934. [Effects of cucurbitacin B on cell proliferation and apoptosis in Hep-2 cells]. (PubMed id 18652313)1 Liu T....Ji W. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    935. The developing human ovary: immunohistochemical analysis of germ-cell-specific VASA protein, BCL-2/BAX expression balance and apoptosis. (PubMed id 18534994)1 Albamonte M.S....Vitullo A.D. (Hum. Reprod. 2008)
    936. The proto-oncogene expression varies over the course of chronic myeloid leukemia. (PubMed id 18534064)1 VidoviA8 A....BoskoviA8 D. (Hematology 2008)
    937. Evaluation of apoptotic cells and immunohistochemical detection of FAS, FAS-L, Bcl-2, Bax, p53 and c-Myc in the skin of patients with chronic venous leg ulcers. (PubMed id 18813857)1 Heising S....JA1nger M. (Int. J. Mol. Med. 2008)
    938. Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. (PubMed id 18769111)1 Wei Y....Levine B. (Autophagy 2008)
    939. G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. (PubMed id 18818203)1 Janumyan Y....Yang E. (J. Biol. Chem. 2008)
    940. GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors. (PubMed id 18653721)1 KyrAPnlahti A....Anttonen M. (Endocrinology 2008)
    941. Prognostic assessment of BCL2-938C&gt;A polymorphism in chronic lymphocytic leukemia. (PubMed id 18156504)1 Rossi D....Gaidano G. (Blood 2008)
    942. Modulation of the BCL-2/BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblasts. (PubMed id 17905238)1 Saed G.M....Diamond M.P. (Fertil. Steril. 2008)
    943. BCL2 and BCL3 are recurrent translocation partners of the IGH locus. (PubMed id 18940474)1 Szymanowska N....Siebert R. (Cancer Genet. Cytogenet. 2008)
    944. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. (PubMed id 17909078)1 Illario M.... Racioppi L. (Blood 2008)
    945. Bcl-2 expression in dermal lymphocytes in lichen planus and psoriasis vulgaris. (PubMed id 18410632)1 Bal N....Bolat F. (J Eur Acad Dermatol Venereol 2008)
    946. Regulatory mechanism of Bcl-2 in uterine leiomyomas. (PubMed id 19205434)1 Ohara N. (amp 2008)
    947. Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma. (PubMed id 19020723)1 Gabriel U....Michel M.S. (Oncol. Rep. 2008)
    948. No death without life: vital functions of apoptotic effectors. (PubMed id 18309324)1 Galluzzi L....Kroemer G. (Cell Death Differ. 2008)
    949. [Relationship between the expressions of lectin-like oxidized low-density lipoprotein receptor-1 and apoptosis associated genes in placenta tissues and the pathogenesis of preeclampsia]. (PubMed id 19035131)1 Meng T....Shang T. (Zhonghua Fu Chan Ke Za Zhi 2008)
    950. Role of S-nitrosylation in apoptosis resistance and carcinogenesis. (PubMed id 18474261)1 Iyer A.K....Rojanasakul Y. (Nitric Oxide 2008)
    951. Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells. (PubMed id 17981569)1 Thangapazham R.L....Maheshwari R.K. (Front. Biosci. 2008)
    952. Ki-67, p53 and bcl-2 analysis in colonic versus rectal adenocarcinoma. (PubMed id 18516322)1 PetriA9or O....CA8runtu I.D. (Rom J Morphol Embryol 2008)
    953. Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins. (PubMed id 18794804)1 Meyerkord C.L....Wang H.G. (Oncogene 2008)
    954. Frequency of BCL2 and BCL6 translocations in follicular lymphoma: relation with histological and clinical features. (PubMed id 18203018)1 DA-az-Alderete A....Menarguez J. (amp 2008)
    955. Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line. (PubMed id 18838868)1 Long J.M....Farwell M.A. (Cell Cycle 2008)
    956. Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas. (PubMed id 18538438)1 Libra M....Carbone A. (J. Hepatol. 2008)
    957. NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. (PubMed id 18279996)1 Watson M.R....Oakley F. (J. Hepatol. 2008)
    958. The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I. (PubMed id 18695940)1 Porcelli A.M....Rugolo M. (Cell. Mol. Life Sci. 2008)
    959. Expression of MDR1, LRP, BCRP and Bcl-2 genes at diagnosis of childhood all: comparison with MRD status after induction therapy. (PubMed id 18806751)1 Fedasenka U.U....Belevcev M.V. (Exp. Oncol. 2008)
    960. Sorbitol-induced apoptosis of human leukemia is mediated by caspase activation and cytochrome c release. (PubMed id 18046541)1 MarfA" G....Sinibaldi-Salimei P. (Arch. Toxicol. 2008)
    961. Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. (PubMed id 18949393)1 Bendardaf R....PyrhAPnen S. (Oncol. Rep. 2008)
    962. Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. (PubMed id 18505729)1 Wan G....Hu C.A. (J. Biol. Chem. 2008)
    963. Antiapoptotic activities of bcl-2 correlate with vascular maturation and transcriptional modulation of human endothelial cells. (PubMed id 18568946)1 Enis D.R....Print C.G. (Endothelium 2008)
    964. Effects of ultra-marathon on circulating DNA and mRNA expression of pro- and anti-apoptotic genes in mononuclear cells. (PubMed id 18651163)1 Atamaniuk J....Mueller M.M. (Eur. J. Appl. Physiol. 2008)
    965. Involvement of pro-apoptotic and anti-apoptotic factors in the early development of the human pituitary gland. (PubMed id 18712678)1 Saraga-Babic M....Stefanovic V. (Histol. Histopathol. 2008)
    966. CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of Bcl-2 and MDR1 genes than CD34- cells in childhood AML. (PubMed id 18228020)1 Shman T.V....Aleinikova O.V. (Ann. Hematol. 2008)
    967. DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis. (PubMed id 18450493)1 Marash L....Kimchi A. (Mol. Cell 2008)
    968. Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy. (PubMed id 18769121)1 Rieber M. and Rieber M.S. (amp 2008)
    969. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? (PubMed id 18314333)1 Chipuk J.E. and Green D.R. (Trends Cell Biol. 2008)
    970. H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression. (PubMed id 18240345)1 Lima V.P....Rabenhorst S.H. (World J. Gastroenterol. 2008)
    971. [Roles of placental cellular apoptosis and bcl-2 expression in fetal growth restriction with unclear etiologies]. (PubMed id 19080514)1 Chen H. and Dai Z.Y. (Zhonghua Fu Chan Ke Za Zhi 2008)
    972. Bcl-2 and Bax expressions in pre-term, term and post-term placentas. (PubMed id 18705844)1 Daher S....Bevilacqua E. (Am. J. Reprod. Immunol. 2008)
    973. EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency. (PubMed id 18566606)1 Lee E.F....Fairlie W.D. (Cell Death Differ. 2008)
    974. Developmental patterns of caspase-3, bax and bcl-2 proteins expression in the human spinal ganglia. (PubMed id 18415689)1 Vukojevic K....Saraga-Babic M. (J. Mol. Histol. 2008)
    975. PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells. (PubMed id 18957415)1 Ruvolo V.R....Ruvolo P.P. (J. Biol. Chem. 2008)
    976. Apoptosis and HIV infection: about molecules and genes. (PubMed id 18220834)1 Cossarizza A. (Curr. Pharm. Des. 2008)
    977. Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells. (PubMed id 18428028)1 Singh S.K....De LeA^n D.D. (Growth Factors 2008)
    978. Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death. (PubMed id 17920946)1 Holst C.M....Oredsson S.M. (Cell Biol. Int. 2008)
    979. Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2. (PubMed id 18719108)1 Katz C....Friedler A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    980. [Expression of OX40 and Bcl-2 in allergic rhinitis]. (PubMed id 19253527)1 Zhao J....Chen X. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    981. Livin and Bcl-2 expression in high-grade osteosarcoma. (PubMed id 17632732)1 Nedelcu T....Toma C.D. (J. Cancer Res. Clin. Oncol. 2008)
    982. Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis. (PubMed id 17957472)1 Scheel-Toellner D....Salmon M. (Apoptosis 2008)
    983. Bcl-2 protects tubular epithelial cells from ischemia reperfusion injury by inhibiting apoptosis. (PubMed id 18468253)1 Suzuki C....Imai E. (Cell Transplant 2008)
    984. sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. (PubMed id 18037229)1 Tian D....Xing C. (Cancer Lett. 2008)
    985. [DMF-induced adult hepatocyte apoptosis and its effects on expression of Bcl-2, Bax and Caspase-3]. (PubMed id 18727869)1 Lu Y.Y....Li X.Z. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008)
    986. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    987. Transplanted heart cardiomyocytes reveal continuous expression of antiapoptotic Bcl-2 protein. (PubMed id 18021997)1 Nozynski J....Zembala M. (Transplant. Proc. 2007)
    988. Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death. (PubMed id 18006836)1 Meslin F....Mehrpour M. (Cancer Res. 2007)
    989. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). (PubMed id 17438366)1 Maiuri M.C....Kroemer G. (Autophagy 2007)
    990. Bcl-2 expression in oral squamous cell carcinoma. (PubMed id 17404013)1 PopoviA8 B....Milasin J. (Ann. N. Y. Acad. Sci. 2007)
    991. High frequency of BCL2 translocation in Thai patients with follicular lymphomas. (PubMed id 18055344)1 Rojnuckarin P....Intragumtornchai T. (Int. J. Hematol. 2007)
    992. Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1. (PubMed id 16874461)1 Xu L....Kuo T.H. (Mol. Cell. Biochem. 2007)
    993. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. (PubMed id 17274640)1 Flores-Delgado G....Berndt N. (J. Proteome Res. 2007)
    994. Immunoreactivity of p53, Mdm2, p21(WAF1/CIP1) Bcl-2, and Bax in soft tissue sarcomas: correlation with histologic grade. (PubMed id 17536310)1 Sabah M....Kay E. (amp 2007)
    995. [Expression of Bax and Bcl-2 apoptotic factors in the conjunctiva of diabetic patients: a preliminary study]. (PubMed id 17978676)1 Khalfaoui T....Meddeb Amel O. (J Fr Ophtalmol 2007)
    996. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. (PubMed id 17289999)1 Willis S.N.... Huang D.C. (Science 2007)
    997. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. (PubMed id 17191123)1 Wan Q.... Liu Y. (Apoptosis 2007)
    998. BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. (PubMed id 17692808)1 Deng J....Letai A. (Cancer Cell 2007)
    999. BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cells. (PubMed id 16841088)1 SepA_lveda P....MiA+ana M.D. (Cell Death Differ. 2007)
    1000. Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: role of Nur77 and Bcl-2. (PubMed id 18073527)1 Kfir S....Yefenof E. (Cell Cycle 2007)
    1001. Ethyl acetate extract of Chinese medicinal herb Sarcandra glabra induces growth inhibition on human leukemic HL-60 cells, associated with cell cycle arrest and up-regulation of pro-apoptotic Bax/Bcl-2 ratio. (PubMed id 17203183)1 Li W.Y....Ooi V.E. (Oncol. Rep. 2007)
    1002. Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. (PubMed id 17418785)1 Bruey J.M....Reed J.C. (Cell 2007)
    1003. Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region. (PubMed id 17913397)1 Bredow S....Tesfaigzi Y. (Gene 2007)
    1004. Apoptosis in peripheral neuroblastic tumors. Immunohistochemical expression of bcl-2 and p53 is related to DNA fragmentation. (PubMed id 17701916)1 MejA-a C....Llombart-Bosch A. (Histol. Histopathol. 2007)
    1005. Anti-apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells. (PubMed id 17230521)7 Zhang X....Wang X. (Int. J. Cancer 2007)
    1006. The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90. (PubMed id 17379601)1 Edlich F....Fischer G. (J. Biol. Chem. 2007)
    1007. A novel calmodulin-Ca2+ target recognition activates the Bcl-2 regulator FKBP38. (PubMed id 17942410)1 Edlich F....LA1cke C. (J. Biol. Chem. 2007)
    1008. Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells. (PubMed id 17272502)1 Nguyen T.M....Ramakrishnan S. (Blood 2007)
    1009. Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro. (PubMed id 18023359)1 John T....Schulze-Tanzil G. (Cytokine 2007)
    1010. A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein. (PubMed id 18069888)1 Feng P....Jung J.U. (PLoS Pathog. 2007)
    1011. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. (PubMed id 17082179)1 Patel J.H. and McMahon S.B. (J. Biol. Chem. 2007)
    1012. [Localization of bcl-2 antiapoptotic protein in the human placenta]. (PubMed id 18411730)1 KorzhevskiA- D.E....Pavlova N.G. (Morfologiia 2007)
    1013. ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. (PubMed id 17875758)1 Joshi A.D....Joshi S.S. (Clin. Cancer Res. 2007)
    1014. Anti-apoptotic activity of Bcl-2 is enhanced by its interaction with RTN3. (PubMed id 17379544)1 Zhu L....Qi Y. (Cell Biol. Int. 2007)
    1015. Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1. (PubMed id 17670745)1 Fernando R....Wimalasena J. (J. Biol. Chem. 2007)
    1016. Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex. (PubMed id 17259174)1 Hou Y....Deng X. (J. Biol. Chem. 2007)
    1017. Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl-2-dependent mechanism. (PubMed id 17916073)1 Cadden I.S....McGinty A. (Histopathology 2007)
    1018. Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. (PubMed id 17363905)1 Shambharkar P.B....Lin X. (EMBO J. 2007)
    1019. Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy. (PubMed id 17727680)1 Sakurai T....Oikawa T. (Cancer Sci. 2007)
    1020. ''Minor'' BCL2 breakpoints in follicular lymphoma: frequency and correlation with grade and disease presentation in 236 cases. (PubMed id 17652637)1 Weinberg O.K....Arber D.A. (J Mol Diagn 2007)
    1021. Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts. (PubMed id 17290286)1 Ryu S.J....Park S.C. (Cell Death Differ. 2007)
    1022. Cytotoxic necrotizing factor 1 prevents apoptosis via the Akt/IkappaB kinase pathway: role of nuclear factor-kappaB and Bcl-2. (PubMed id 17507655)1 Miraglia A.G....Fabbri A. (Mol. Biol. Cell 2007)
    1023. WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. (PubMed id 16443602)1 Tomita Y....Moll U.M. (J. Biol. Chem. 2006)
    1024. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. (PubMed id 17097560)1 Konopleva M....Andreeff M. (Cancer Cell 2006)
    1025. Detection of human papillomavirus and relevant tumor suppressors and oncoproteins in laryngeal tumors. (PubMed id 17145812)1 Manjarrez M.E....Gariglio P. (Clin. Cancer Res. 2006)
    1026. Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1. (PubMed id 16790527)1 Aquilano K....Ciriolo M.R. (FASEB J. 2006)
    1027. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. (PubMed id 16697956)1 Certo M....Letai A. (Cancer Cell 2006)
    1028. Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression. (PubMed id 16186795)1 Heckman C.A....Boxer L.M. (Oncogene 2006)
    1029. Induction of Bcl-2 by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione. (PubMed id 17050165)1 Sahin M....Methner A. (Free Radic. Res. 2006)
    1030. Bcl-2 changes conformation to inhibit Bax oligomerization. (PubMed id 16642033)1 Dlugosz P.J....Andrews D.W. (EMBO J. 2006)
    1031. Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. (PubMed id 16469847)1 Kobayashi S....Liang Q. (FASEB J. 2006)
    1032. p53 and p27 as predictors of clinical outcome for rectal-cancer patients receiving neoadjuvant therapy. (PubMed id 17360176)1 Lin L.C....Lu C.L. (Surg Oncol 2006)
    1033. Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35. (PubMed id 16472763)1 Clementi M.E....Misiti F. (Biochem. Biophys. Res. Commun. 2006)
    1034. Lysosomal cathepsin initiates apoptosis, which is regulated by photodamage to Bcl-2 at mitochondria in photodynamic therapy using a novel photosensitizer, ATX-s10 (Na). (PubMed id 16820876)1 Ichinose S....Kato H. (Int. J. Oncol. 2006)
    1035. Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma. (PubMed id 16173075)1 Magistrelli P....Picciocchi A. (J. Cell. Biochem. 2006)
    1036. Role of Bcl-2 expression for productive herpes simplex virus 2 replication. (PubMed id 16950491)1 Sciortino M.T....Mastino A. (Virology 2006)
    1037. Bcl-2 protects against oxidative stress while inducing premature senescence. (PubMed id 16545683)1 LA^pez-Diazguerrero N.E....KAPnigsberg M. (amp 2006)
    1038. Regulation of bcl-2 expression by Ubc9. (PubMed id 16566921)1 Lu Z....Mo Y.Y. (Exp. Cell Res. 2006)
    1039. Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation. (PubMed id 17015762)1 Kim W.U....Cho C.S. (J. Immunol. 2006)
    1040. Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (PubMed id 16799010)1 Wallace D.J....Chan C.C. (amp 2006)
    1041. Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index. (PubMed id 16638854)1 Callagy G.M....Caldas C. (Clin. Cancer Res. 2006)
    1042. Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. (PubMed id 16520895)1 Hsu P.C....Liu G.Y. (Apoptosis 2006)
    1043. T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio. (PubMed id 16307838)1 Chen J....Wang Z. (Food Chem. Toxicol. 2006)
    1044. [Effect of erythromycin on apoptosis of epithelial cell in nasal polyps]. (PubMed id 17007374)1 Xu S.N....Jin Y.G. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2006)
    1045. Depression of MAD2 inhibits apoptosis of gastric cancer cells by upregulating Bcl-2 and interfering mitochondrion pathway. (PubMed id 16714000)1 Du Y....Fan D. (Biochem. Biophys. Res. Commun. 2006)
    1046. NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. (PubMed id 16998187)1 Dai J....Yang D. (Nucleic Acids Res. 2006)
    1047. Preferential survival of acute lymphoblastic leukemia cells at 33 degrees C is associated with up-regulation of bcl-2. (PubMed id 16840204)1 Morsi H....Jewell A.P. (amp 2006)
    1048. Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. (PubMed id 16707568)1 Rambold A.S....Tatzelt J. (Mol. Biol. Cell 2006)
    1049. Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression. (PubMed id 16636671)1 Zhang J....Tang D. (Oncogene 2006)
    1050. Abnormal intracellular level of Bax in CD3+ cells from untreated B-cell chronic lymphocytic leukemia patients. (PubMed id 17118768)1 Scamardella F....Brini M. (Lab Hematol 2006)
    1051. Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells. (PubMed id 16850164)1 Miura Y....Otsuki T. (Apoptosis 2006)
    1052. Expression of Bcl-2 and Bax protein in normal pineal gland in children and young adult. (PubMed id 16832704)1 Marcol W....Lewin-Kowalik J. (J. Mol. Histol. 2006)
    1053. N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. (PubMed id 16530191)1 Selvakumar P....Sharma R.K. (FEBS Lett. 2006)
    1054. Apoptosis induction by activator protein 2alpha involves transcriptional repression of Bcl-2. (PubMed id 16533807)1 Wajapeyee N....Somasundaram K. (J. Biol. Chem. 2006)
    1055. Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS. (PubMed id 16895478)7 Thomadaki H....Scorilas A. (Biol. Chem. 2006)
    1056. Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. (PubMed id 16434970)1 Han Y.H....Zhang X.K. (Oncogene 2006)
    1057. Anti-beta-2 glycoprotein I antibodies affect Bcl-2 and Bax trophoblast expression without evidence of apoptosis. (PubMed id 16855163)1 di Simone N....Caruso A. (Ann. N. Y. Acad. Sci. 2006)
    1058. Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins. (PubMed id 16167175)1 Soane L. and Fiskum G. (J. Bioenerg. Biomembr. 2005)
    1059. CD4+ T cells downregulate Bcl-2 in germinal centers. (PubMed id 15981087)1 Schenka A.A....Brousset P. (J. Clin. Immunol. 2005)
    1060. Comparison of benign keratoses using p53, bcl-1, and bcl-2. (PubMed id 15811121)1 Ko C.J....Binder S.W. (J. Cutan. Pathol. 2005)
    1061. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. (PubMed id 15840562)1 Raghavan S.C....Lieber M.R. (J. Biol. Chem. 2005)
    1062. Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity. (PubMed id 15619620)1 Youn C.K....You H.J. (Nat. Cell Biol. 2005)
    1063. Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins. (PubMed id 15907209)1 Zhang W....Zhang M. (BMC Cancer 2005)
    1064. Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. (PubMed id 15799693)1 Maguire P....Lyng F.M. (Radiat. Res. 2005)
    1065. Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim. (PubMed id 15634885)1 Kirschnek S....HAocker G. (J. Immunol. 2005)
    1066. Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms. (PubMed id 16243795)1 Kondo E....Yoshino T. (Clin. Cancer Res. 2005)
    1067. Proapoptotic BAX and BAK control multiple initiator caspases. (PubMed id 15776018)1 Ruiz-Vela A....Korsmeyer S.J. (EMBO Rep. 2005)
    1068. Overexpression of Bcl-2 inhibits nuclear localization of annexin I during tumor necrosis factor-alpha-mediated apoptosis in porcine renal LLC-PK1 cells. (PubMed id 15544840)1 Ishido M. (Regul. Pept. 2005)
    1069. Dual role for Bcl-2 in antibody affinity maturation. (PubMed id 15803126)1 Dunn-Walters D. and Spencer J. (Nat. Cell Biol. 2005)
    1070. Catalase plays a critical role in the CSF-independent survival of human macrophages via regulation of the expression of BCL-2 family. (PubMed id 16204228)1 Komuro I....Akagawa K.S. (J. Biol. Chem. 2005)
    1071. Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin. (PubMed id 15990872)1 Edlich F.... Fischer G.&