Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL2 Gene

protein-coding GIFtS: 74
GCID: GC18M060763

B-cell CLL/lymphoma 2

Explore 371 diseases affiliated with
BCL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 2¹ ²
Bcl-2¹ ²
PPP1R50¹ ²
Apoptosis Regulator Bcl-2²
Protein Phosphatase 1, Regulatory Subunit 50²

External Ids:	HGNC: 990¹	Entrez Gene: 596²	Ensembl: ENSG00000171791⁷	OMIM: 151430⁵	UniProtKB: P10415³

Export aliases for BCL2 gene to outside databases

Previous GC identifers: GC18M060629 GC18M058939 GC18M058941 GC18M057487

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2:

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such

as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus,

is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in

their C-terminal ends. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural

cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback

loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the

mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

summary for BCL2:

Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein

family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as

Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2

proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma

and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members

contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial

and other intracellular membranes.

Gene Wiki entry for BCL2 (Bcl-2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL2 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCL2 promoter sequence

Search SABiosciences Chromatin IP Primers for BCL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3

BCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M060763: view genomic region (about GC identifiers)

Start:	60,790,579 bp from pter	End:	60,987,361 bp from pter
Size:	196,783 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415 (See protein sequence)

Recommended Name: Apoptosis regulator Bcl-2

Size: 239 amino acids; 26266 Da

Subunit: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires

intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Interacts with EI24 (By

similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2

to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an

ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via the BH4

domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic

activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2

complex. Interacts with BOP

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass

membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein

6/9 PDB 3D structures from and Proteopedia for BCL2 (see all 9):

1G5M (3D)

1GJH (3D)

1YSW (3D)

2O21 (3D)

2O22 (3D)

2O2F (3D)

Secondary accessions: P10416 Q13842 Q16197

Alternative splicing: 2 isoforms: P10415-1 P10415-2

Explore the universe of human proteins at neXtProt for BCL2: NX_P10415

Post-translational modifications:

Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation

on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In

the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and

stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates

starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity)¹

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic

activity, causes the release of cytochrome c into the cytosol promoting further caspase activity¹

Monoubiquitinated by PARK2, leading to increase its stability¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10415

BCL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000624.2 NP_000648.2

ENSEMBL proteins:

ENSP00000381185 ENSP00000329623 ENSP00000466417 ENSP00000404214

Reactome Protein details: P10415
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for BCL2 (Bcl-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: BCL2 OriGene Protein Over-expression Lysate (see all 2): BCL2 OriGene Custom Protein Services for BCL2
	GenScript Custom Purified and Recombinant Proteins Services for BCL2
	Novus Biologicals BCL2 Proteins
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for BCL2
	Browse Proteins at Uscn

Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IDA	7896880
GO:0005737	cytoplasm	IDA	7546744
GO:0005739	mitochondrion	IDA	7896880

BCL2 for ontologies About GeneDecksing

BCL2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2
	R&D Systems Antibodies for BCL2 (Bcl-2)
	Cell Signaling Technology (CST) Antibodies for BCL2 (Bcl-2)
	OriGene Antibodies (see all 4): BCL2 OriGene Custom Antibody Services for BCL2
	GenScript Superior Antibodies for BCL2
	Novus Biologicals BCL2 Antibodies
	Abcam antibodies for BCL2
	Browse Antibodies at Uscn
	ThermoFisher Antibody for BCL2

Assay Products for BCL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for BCL2 (Bcl-2) (see all)
	GenScript Custom Assay Services for BCL2
	Cell Signaling Technology (CST) Sandwich ELISA Kits for BCL2 (Bcl-2)
	Enzo Life Sciences assays for BCL2
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCL2 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR020731 Bcl2_BH4_motif_CS

IPR020728 Bcl2_BH3_motif_CS

IPR003093 Bcl2_BH4

IPR002475 Bcl2-like

IPR026298 Blc2_fam

Graphical View of Domain Structure for InterPro Entry P10415

ProtoNet protein and cluster: P10415

2 Blocks protein families:

IPB000712 Apoptosis regulator Bcl-2 protein

IPB003093 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural

cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback

loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the

mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

Genatlas biochemistry entry for BCL2:

inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by inhibiting the release of

cytochrome from the mitochondrial and by protecting a wide variety of cells including B cells and neuronal

cells,activated by nerve growth factor,mediated by the p42/p44 MAPK cascade,inhibited by phosphorylation mediated by

microtubule-damaging drugs through JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also modulating

CDK2 activation during thymocyte apoptosis,overexpressed in endometrial carcinoma

miRNA Products:		miRTarBase miRNAs that target BCL2: hsa-mir-630 (MIRT005578), hsa-mir-34c-5p (MIRT003979), hsa-mir-16 (MIRT001800), hsa-let-7a (MIRT000418), hsa-mir-181d (MIRT003498), hsa-mir-29b (MIRT003290), hsa-mir-34b (MIRT000065), hsa-mir-181c (MIRT003499), hsa-mir-15b (MIRT000978), hsa-mir-20a (MIRT003011), hsa-mir-15a (MIRT000815), hsa-mir-451 (MIRT005744), hsa-mir-181a (MIRT003501), hsa-mir-204 (MIRT000192), hsa-mir-17 (MIRT003014), hsa-mir-29a (MIRT003291), hsa-mir-21 (MIRT000159), hsa-mir-29c (MIRT003289), hsa-mir-34a (MIRT002298), hsa-mir-195 (MIRT005362), hsa-mir-181b (MIRT003500), hsa-mir-192 (MIRT004844), hsa-mir-153 (MIRT000290)

		OriGene 3'-UTR Clone (see all 2): BCL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2
		8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2 (see all 117):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2 (see all 7) OriGene shRNA RFP: BCL2 OriGene siRNA: BCL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BCL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
		Sino Biological Human cDNA Clone for BCL2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BCL2
		Search LifeMap BioReagents cell lines for BCL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IDA	10620603
GO:0005515	protein binding	IPI	--
GO:0008134	transcription factor binding	IEA	--
GO:0015267	channel activity	IDA	9219694
GO:0019903	protein phosphatase binding	--	--

BCL2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BCL2:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for BCL2: Bcl2^tm1Dlo Bcl2^tm1Sjk Bcl2^tm1Tsu
15/21 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Bcl2) (see all 21):

adipose tissue	cardiovascular system	cellular	craniofacial	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	muscle	nervous system

BCL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/74 super-pathways (see all 74) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/11 pathways (see all 11)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

Development HGF signaling pathway

Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1	0.24	Neurotrophin signaling pathway	0.20
Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1	0.24	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2	0.15
Apoptosis and survival_Role of CDK5 in neuronal death and survival	0.24	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2	0.15
Apoptosis and survival Role of CDK5 in neuronal death and survival	0.24

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	1.00	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins	0.24
Activation of BH3-only proteins	0.30	Intrinsic Pathway for Apoptosis	0.23
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins	0.24	Activation of BAD and translocation to mitochondria	0.15

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

TWEAK Pathway

HIV-1 Nef- Negative effector of Fas and TNF-alpha	0.42	Apoptotic Pathways Triggered By HIV1	0.37
Apoptosis and survival_TNFR1 signaling pathway	0.40	Apoptosis through Death Receptors	0.32
Apoptosis and survival TNFR1 signaling pathway	0.40

Pathway sources
See GeneCards unified pathways
Show all pathways

5/16 EMD Millipore Pathways for BCL2 (see all 16)

	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Development EPO-induced Jak-STAT pathway
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
	Apoptosis and survival TNFR1 signaling pathway

3 R&D Systems Pathways for BCL2

	IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Apoptosis Signaling Pathways
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/48 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCL2 (see all 48)

	FLT3 Signaling
	14-3-3 Induced Apoptosis
	IL-4 Pathway
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 Cell Signaling Technology (CST) Pathway for BCL2

Apoptosis and Autophagy

1 Tocris Bioscience Pathway for BCL2

Apoptosis Pathway

5/15 GeneGo (Thomson Reuters) Pathways for BCL2 (see all 15)

	Apoptosis and survival BAD phosphorylation
	Transcription P53 signaling pathway
	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
	Apoptosis and survival FAS signaling cascades

5/30 BioSystems Pathways for BCL2 (see all 30)

	FAS pathway and Stress induction of HSP regulation
	DNA damage response (only ATM dependent)
	Focal Adhesion
	Senescence and Autophagy
	Integrated Breast Cancer Pathway

5/10 Reactome Pathways for BCL2 (see all 10)

	Activation of BH3-only proteins
	Activation of BAD and translocation to mitochondria
	The NLRP1 inflammasome
	Inflammasomes
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

2 PharmGKB Pathways for BCL2

	Busulfan Pathway, Pharmacodynamics
	Vinka Alkaloid Pathway, Pharmacokinetics

5/12 Kegg Pathways (Kegg details for BCL2) (see all 12):

	Protein processing in endoplasmic reticulum
	Apoptosis
	Focal adhesion
	Neurotrophin signaling pathway
	Cholinergic synapse

BCL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BCL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

147/155 Interacting proteins for BCL2 (P10415^{1, 2, 3} ENSP00000329623⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 155) (see top 5)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53BP2	Q13625²^,³, ENSP00000341957⁴	MINT-7235804 MINT-7235946 MINT-7235823 MINT-7236118 MINT-7236027 MINT-7236079 MINT-7236102 MINT-7236042 MINT-7236003 MINT-7235965 MINT-7235839 MINT-7236061 MINT-7235784 I2D: score=4 STRING: ENSP00000341957
AMBRA1	Q9C0C7²^,³, ENSP00000318313⁴	MINT-8182706 MINT-8182670 MINT-8182688 MINT-8182559 MINT-8182625 MINT-8174974 MINT-8182589 MINT-8182650 MINT-8182607 MINT-8182574 I2D: score=1 STRING: ENSP00000318313
BECN1	Q14457¹^,²^,³, ENSP00000355231⁴	EBI-77694,EBI-949378 MINT-8182780 MINT-4821014 MINT-4820784 MINT-8095220 MINT-8182706 MINT-7014531 MINT-7712827 MINT-8095201 I2D: score=4 STRING: ENSP00000355231
TP53	P04637¹^,²^,³, ENSP00000269305⁴	EBI-77694,EBI-366083 MINT-7291988 MINT-7292025 MINT-7291975 I2D: score=2 STRING: ENSP00000269305
BCL2L11	O43521¹^,²^,³	EBI-77694,EBI-1002160 MINT-6629252 MINT-4980319 I2D: score=12
BAX	Q07812¹^,²^,³, ENSP00000293288⁴	EBI-77694,EBI-516580 MINT-4980319 I2D: score=10 STRING: ENSP00000293288
MAPK1	P28482²^,³, ENSP00000215832⁴	MINT-51440 MINT-51441 I2D: score=4 STRING: ENSP00000215832
NAF1	Q96HR8²^,³, ENSP00000274054⁴	MINT-7717145 MINT-7712862 I2D: score=1 STRING: ENSP00000274054
PPP3R1	P63098²^,³, ENSP00000234310⁴	MINT-58237 MINT-58234 I2D: score=1 STRING: ENSP00000234310
BID	P55957¹^,³, ENSP00000318822⁴	EBI-77694,EBI-519672 I2D: score=9 STRING: ENSP00000318822
BAD	Q92934¹^,³, ENSP00000309103⁴	EBI-77694,EBI-700771 I2D: score=8 STRING: ENSP00000309103
BBC3	Q9BXH1¹^,³, ENSP00000404503⁴	EBI-77694,EBI-519884 I2D: score=7 STRING: ENSP00000404503
BCL2L1	Q07817²^,³, ENSP00000302564⁴	MINT-4980319 I2D: score=3 STRING: ENSP00000302564
PMAIP1	Q13794¹^,³, ENSP00000326119⁴	EBI-77694,EBI-707392 I2D: score=3 STRING: ENSP00000326119
SIVA1	O15304¹^,³, ENSP00000329213⁴	EBI-77694,EBI-520756 I2D: score=1 STRING: ENSP00000329213
MT-RNR2	Q8IVG9²^,³	MINT-19417 I2D: score=1
MDM4	O15151²^,³, ENSP00000356150⁴	MINT-7291988 MINT-7292013 MINT-7292025 MINT-7291975 MINT-7292000 I2D: score=1 STRING: ENSP00000356150
FKBP8	Q14318²^,³, ENSP00000222308⁴	MINT-56638 MINT-56636 MINT-56637 I2D: score=5 STRING: ENSP00000222308
PPP2CA	P67775²^,³, ENSP00000418447⁴	MINT-51442 MINT-51443 I2D: score=4 STRING: ENSP00000418447
SMN1	Q16637³, ENSP00000370083⁴	I2D: score=2 STRING: ENSP00000370083
BIK	Q13323¹^,³, ENSP00000216115⁴	EBI-77694,EBI-700794 I2D: score=6 STRING: ENSP00000216115
BNIP3L	O60238¹^,³, ENSP00000370003⁴	EBI-77694,EBI-849893 I2D: score=4 STRING: ENSP00000370003
MCL1	Q07820², ENSP00000358022⁴	MINT-8095201 MINT-4980319 STRING: ENSP00000358022
NLRP1	Q9C000¹^,³, ENSP00000269280⁴	EBI-77694,EBI-1220518 I2D: score=2 STRING: ENSP00000269280
MAPK8	P45983²^,³, ENSP00000353483⁴	MINT-56639 I2D: score=4 STRING: ENSP00000353483
NR4A1	P22736¹^,³, ENSP00000243050⁴	EBI-77694,EBI-721550 I2D: score=4 STRING: ENSP00000243050
HSPA1A	P08107³, ENSP00000364802⁴	I2D: score=3 STRING: ENSP00000364802
SMN2	Q16637³, ENSP00000370119⁴	I2D: score=2 STRING: ENSP00000370119
BCAP31	P51572¹^,³, ENSP00000392330⁴	EBI-77694,EBI-77683 I2D: score=3 STRING: ENSP00000392330
NMT2	O60551²^,³, ENSP00000367407⁴	MINT-1795413 I2D: score=2 STRING: ENSP00000367407
BAK1	Q16611³, ENSP00000363591⁴	I2D: score=4 STRING: ENSP00000363591
BNIP3	Q12983³, ENSP00000357625⁴	I2D: score=4 STRING: ENSP00000357625
CASP8	Q14790³, ENSP00000351273⁴	I2D: score=4 STRING: ENSP00000351273
RAD9A	Q99638³, ENSP00000311360⁴	I2D: score=4 STRING: ENSP00000311360
TMBIM6	P55061³, ENSP00000389277⁴	I2D: score=4 STRING: ENSP00000389277
BLK	P51451³, ENSP00000259089⁴	I2D: score=3 STRING: ENSP00000259089
BNIP1	Q12981³, ENSP00000231668⁴	I2D: score=3 STRING: ENSP00000231668
BNIPL	Q7Z465³, ENSP00000357927⁴	I2D: score=3 STRING: ENSP00000357927
CASP3	P42574³, ENSP00000311032⁴	I2D: score=3 STRING: ENSP00000311032
HSPA1B	P08107³	I2D: score=3
PPP1CA	P62136³, ENSP00000326031⁴	I2D: score=3 STRING: ENSP00000326031
SPNS1	Q9H2V7³, ENSP00000309945⁴	I2D: score=3 STRING: ENSP00000309945
BCLAF1	Q9NYF8³, ENSP00000031135⁴	I2D: score=2 STRING: ENSP00000031135
CYCS	P99999³, ENSP00000307786⁴	I2D: score=2 STRING: ENSP00000307786
ITPR1	Q14643³, ENSP00000405934⁴	I2D: score=2 STRING: ENSP00000405934
MAPK11	Q15759³, ENSP00000333685⁴	I2D: score=2 STRING: ENSP00000333685
MAPK3	P27361³, ENSP00000263025⁴	I2D: score=2 STRING: ENSP00000263025
MYC	P01106³, ENSP00000367207⁴	I2D: score=2 STRING: ENSP00000367207
NRAS	P01111³, ENSP00000358548⁴	I2D: score=2 STRING: ENSP00000358548
PPP2R4	Q15257³, ENSP00000351885⁴	I2D: score=2 STRING: ENSP00000351885
PRKACA	P17612³, ENSP00000309591⁴	I2D: score=2 STRING: ENSP00000309591
SF1	Q15637³, ENSP00000366607⁴	I2D: score=2 STRING: ENSP00000366607
BAG4	O95429³, ENSP00000287322⁴	I2D: score=1 STRING: ENSP00000287322
BFAR	Q9NZS9³, ENSP00000261658⁴	I2D: score=1 STRING: ENSP00000261658
CAPN2	P17655³, ENSP00000295006⁴	I2D: score=1 STRING: ENSP00000295006
CASP2	P42575³, ENSP00000312664⁴	I2D: score=1 STRING: ENSP00000312664
CUL3	Q13618³, ENSP00000264414⁴	I2D: score=1 STRING: ENSP00000264414
EPHB2	P29323³, ENSP00000363763⁴	I2D: score=1 STRING: ENSP00000363763
IRS2	Q9Y4H2³, ENSP00000365016⁴	I2D: score=1 STRING: ENSP00000365016
KEAP1	Q14145³, ENSP00000171111⁴	I2D: score=1 STRING: ENSP00000171111
PARK2	O60260³, ENSP00000355865⁴	I2D: score=1 STRING: ENSP00000355865
PML	P29590³, ENSP00000268058⁴	I2D: score=1 STRING: ENSP00000268058
PPP1CC	P36873³, ENSP00000335084⁴	I2D: score=1 STRING: ENSP00000335084
RBX1	P62877³, ENSP00000216225⁴	I2D: score=1 STRING: ENSP00000216225
BMF	Q96LC9³, ENSP00000346697⁴	I2D: score=5 STRING: ENSP00000346697
BNIP2	Q12982³, ENSP00000267859⁴	I2D: score=4 STRING: ENSP00000267859
RAF1	P04049³, ENSP00000251849⁴	I2D: score=4 STRING: ENSP00000251849
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
HRK	O00198³, ENSP00000257572⁴	I2D: score=4 STRING: ENSP00000257572
PIN1	Q13526³, ENSP00000247970⁴	I2D: score=3 STRING: ENSP00000247970
PPP3CA	Q08209³, ENSP00000378323⁴	I2D: score=2 STRING: ENSP00000378323
BAG3	O95817³, ENSP00000358081⁴	I2D: score=1 STRING: ENSP00000358081
AVEN	Q9NQS1³, ENSP00000306822⁴	I2D: score=1 STRING: ENSP00000306822
BCL2L10	Q9HD36³, ENSP00000260442⁴	I2D: score=2 STRING: ENSP00000260442
BCL2L14	Q9BZR8³, ENSP00000309132⁴	I2D: score=1 STRING: ENSP00000309132
CDK2	P24941³, ENSP00000266970⁴	I2D: score=2 STRING: ENSP00000266970
CPT1A	P50416³, ENSP00000265641⁴	I2D: score=2 STRING: ENSP00000265641
HRAS	P01112³, ENSP00000309845⁴	I2D: score=2 STRING: ENSP00000309845
ITM2B	Q9Y287³, ENSP00000367828⁴	I2D: score=3 STRING: ENSP00000367828
KRAS	P01116³, ENSP00000256078⁴	I2D: score=2 STRING: ENSP00000256078
MAPK14	Q16539³, ENSP00000229794⁴	I2D: score=2 STRING: ENSP00000229794
MOAP1	Q96BY2³, ENSP00000298894⁴	I2D: score=4 STRING: ENSP00000298894
PARP1	P09874³, ENSP00000355759⁴	I2D: score=3 STRING: ENSP00000355759
PKMYT1	Q99640³, ENSP00000262300⁴	I2D: score=2 STRING: ENSP00000262300
PPP2R5A	Q15172³, ENSP00000261461⁴	I2D: score=3 STRING: ENSP00000261461
PRKCA	P17252³, ENSP00000284384⁴	I2D: score=2 STRING: ENSP00000284384
PSEN1	P49768³, ENSP00000326366⁴	I2D: score=3 STRING: ENSP00000326366
PXN	P49023³, ENSP00000228307⁴	I2D: score=1 STRING: ENSP00000228307
RRAS	P10301³, ENSP00000246792⁴	I2D: score=3 STRING: ENSP00000246792
RTN4	Q9NQC3³, ENSP00000337838⁴	I2D: score=3 STRING: ENSP00000337838
SERPINB8	P50452³, ENSP00000331368⁴	I2D: score=1 STRING: ENSP00000331368
SOD1	P00441³, ENSP00000270142⁴	I2D: score=3 STRING: ENSP00000270142
VRK2	Q86Y07³, ENSP00000342381⁴	I2D: score=2 STRING: ENSP00000342381
DYNLL1	P63167³, ENSP00000242577⁴	I2D: score=1 STRING: ENSP00000242577
IRS1	P35568³, ENSP00000304895⁴	I2D: score=1 STRING: ENSP00000304895
TOMM20	Q15388³, ENSP00000355566⁴	I2D: score=3 STRING: ENSP00000355566
PPP1CB	P62140³, ENSP00000296122⁴	I2D: score=2 STRING: ENSP00000296122
CALR	P27797²	MINT-8095220 MINT-8095201
ATP2A2	P16615³	I2D: score=2
BAG1	Q99933³	I2D: score=2
RHEB	Q15382³	I2D: score=2
TP53AIP1	Q9HCN2³	I2D: score=2
BLID	Q8IZY5³	I2D: score=1
CDK1	P06493³	I2D: score=1
LGALS3	P17931³	I2D: score=1
PRNP	P04156³	I2D: score=1
BCL2	P10415¹	EBI-77694,EBI-77694
DAPK1	P53355²	MINT-7014531
HSPA9	P38646²	MINT-8095201
BCL2L2	ENSP00000250405⁴	STRING: ENSP00000250405
CREB1	ENSP00000387699⁴	STRING: ENSP00000387699
CREBBP	ENSP00000262367⁴	STRING: ENSP00000262367
MAX	ENSP00000351490⁴	STRING: ENSP00000351490
MTOR	ENSP00000354558⁴	STRING: ENSP00000354558
MYB	ENSP00000339992⁴	STRING: ENSP00000339992
POU4F1	ENSP00000366413⁴	STRING: ENSP00000366413
RXRA	ENSP00000419692⁴	STRING: ENSP00000419692
STAT1	ENSP00000354394⁴	STRING: ENSP00000354394
RXRG	ENSP00000352900⁴	STRING: ENSP00000352900
TFAP2A	ENSP00000368924⁴	STRING: ENSP00000368924
ZBTB17	ENSP00000364895⁴	STRING: ENSP00000364895
AKT1	ENSP00000270202⁴	STRING: ENSP00000270202
AKT2	ENSP00000375892⁴	STRING: ENSP00000375892
AKT3	ENSP00000263826⁴	STRING: ENSP00000263826
APAF1	ENSP00000353059⁴	STRING: ENSP00000353059
CASP9	ENSP00000330237⁴	STRING: ENSP00000330237
DDIT3	ENSP00000340671⁴	STRING: ENSP00000340671
CASP10	ENSP00000286186⁴	STRING: ENSP00000286186
HNRNPD	ENSP00000313199⁴	STRING: ENSP00000313199
HSP90AA1	ENSP00000335153⁴	STRING: ENSP00000335153
MEX3D	ENSP00000384398⁴	STRING: ENSP00000384398
VDAC1	ENSP00000265333⁴	STRING: ENSP00000265333
BCL2L12	ENSP00000246785⁴	STRING: ENSP00000246785
CISD2	ENSP00000273986⁴	STRING: ENSP00000273986
CRYAA	ENSP00000291554⁴	STRING: ENSP00000291554
CRYAB	ENSP00000227251⁴	STRING: ENSP00000227251
ITLN1	ENSP00000323587⁴	STRING: ENSP00000323587
SPIN1	ENSP00000365019⁴	STRING: ENSP00000365019
SMC3	ENSP00000354720⁴	STRING: ENSP00000354720
NR3C1	ENSP00000231509⁴	STRING: ENSP00000231509
Bad	Q61337¹	EBI-77694,EBI-400328
Bmf	Q91ZE9¹	EBI-77694,EBI-708032
--	ENSP00000306043⁴	STRING: ENSP00000306043
--	Q63690²	MINT-2729587
--	ENSP00000350311⁴	STRING: ENSP00000350311
--	ENSP00000418684⁴	STRING: ENSP00000418684
--	ENSP00000224112⁴	STRING: ENSP00000224112

About this table

Gene Ontology (GO): 5/154 biological process terms (GO ID links to tree view) (see all 154): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0000209	protein polyubiquitination	IDA	16717086
GO:0000902	cell morphogenesis	--	--
GO:0001101	response to acid	IEA	--
GO:0001503	ossification	IEA	--

BCL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BCL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for BCL2

Compounds for BCL2 available from Tocris Bioscience About this table

Compound	Action	CAS #
2,3-DCPE hydrochloride	Selectively induces cancer cell apoptosis	[418788-90-6]
Gossypol	Pro-apoptotic; downregulates Bcl-2 and Bcl-XL	[303-45-7]
HA14-1	Bcl-2 inhibitor. Induces apoptosis	[65673-63-4]

3 DrugBank Compounds for BCL2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Docetaxel	Docetaxel anhydrous (see all 3)	114977-28-5	target	--	15643508 15161985 15714982 15685445 17674353 15277270
Paclitaxel	7-epi-Paclitaxel (see all 5)	33069-62-4	target	inhibitor	17119350 16741658 17062688 16895478 17230521
Rasagiline	--	136236-51-6	target	activator	12057839 14555244 16148027 12043833 12200198

10/126 Novoseek chemical compound relationships for BCL2 gene (see all 126) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
genasense	81.3	45	16584297 (3), 16564596 (3), 11751483 (2), 12393493 (1) (see all 24)
noxa	75.3	52	19372561 (3), 17018621 (3), 16673057 (2), 19540835 (2) (see all 34)
dutp	75.2	39	9212738 (1), 11920781 (1), 12210368 (1), 14761612 (1) (see all 38)
adpribose	71.7	49	12490780 (2), 11328292 (1), 11896536 (1), 18767861 (1) (see all 44)
paclitaxel	71.3	393	9716607 (8), 9699642 (7), 19671798 (6), 10097113 (6) (see all 99)
etoposide	68.8	137	10367743 (4), 8752171 (4), 9554589 (4), 8395979 (4) (see all 86)
doxorubicin	66.8	175	8781438 (6), 12579337 (3), 18498876 (3), 19818735 (3) (see all 96)
oridonin	66.3	15	17260801 (3), 15008459 (2), 15703811 (2), 16638644 (1) (see all 10)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide	66.1	6	12144824 (1), 15033191 (1), 18471799 (1), 15749633 (1) (see all 6)
paraffin	65.4	126	9343323 (4), 9521469 (1), 10652623 (1), 10491515 (1) (see all 99)

Search CenterWatch for drugs/clinical trials and news about BCL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BCL2 gene (2 alternative transcripts):

NM_000633.2 NM_000657.2

Unigene Cluster for BCL2:

B-cell CLL/lymphoma 2

Hs.150749 [show with all ESTs]

Unigene Representative Sequence: NM_000633

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000398117(uc002liu.1) ENST00000333681(uc002lit.1) ENST00000590515

ENST00000589955 ENST00000444484(uc002liv.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BCL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2
		8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2 (see all 117):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2 (see all 7) OriGene shRNA RFP: BCL2 OriGene siRNA: BCL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BCL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2

Additional cDNA sequence:

AF401211.1 BC027258.1 EU287875.1 M13994.1 M13995.1 M14745.1 X06487.1

4 DOTS entries:

DT.216205 DT.100749960 DT.86998979 DT.40316825

24/148 AceView cDNA sequences (see all 148):

AA321638 F04196 BQ224622 AF401211 BG503428 BF222234 BM986952 BM973833

AI261915 W61100 AI391699 BE503573 F07940 BE550816 AL703462 BM463468

AI627828 N42615 BC027258 BM996398 N29770 AI480094 CB118071 AI142026

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2 About this scheme

ExUns:	1a	·	1b	^	2	^	3
SP1:
SP2:

ECgene alternative splicing isoforms for BCL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTGGAGA

About this image

BCL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

White adipocyte-like cells (Differentiation of w...)

Brown adipocyte-like cells (Differentiation of w...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BCL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL2

SOURCE GeneReport for Unigene cluster: Hs.150749

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Tissue specificity: Expressed in a variety of tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2 (see all 34):

Neurogenesis in human mouse rat

Lung Cancer in human mouse rat

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

Inflammasomes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BCL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BCL2 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BCL2¹	B-cell CLL/lymphoma 2	75.51(n) 77.39(a)		396282 NM_205339.1 NP_990670.1
lizard (Anolis carolinensis)	Reptilia	BCL2⁶	--	70(a)	1 ↔ 1	GL344304.1(26465-27025)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-217f4.3⁶ CU695001.1⁶	--	49(a) 46(a)	1 ↔ many 1 ↔ many	2(12979720-13007658) 24(29060361-29151442)

ENSEMBL Gene Tree for BCL2 (if available)
TreeFam Gene Tree for BCL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BCL2 gene

BAK1² BCL2L2² BCL2L1² BAX²

4 SIMAP similar genes for BCL2 using alignment to 3 protein entries: BCL2_HUMAN (see all proteins):

bcl-2 BCL2L2-PABPN1 BCL2L2 BCL2L1

BCL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35275357^1,2	C	--	57648853(+)	`CTAAT-/TTAG TTGTT`	1	--	int¹		0	--	--	--	--
rs188357713^1,2		--	60765382(+)	`TGGGGA/GGATGC`	1	--	int¹		0	--	--	--	--
rs4940570^1,2	C,F,	--	60765568(+)	`ATTTCA/GGGATT`	1	--	int¹		3		WA NA EA	358
rs72939458^1,2	C,F,	--	60765648(+)	`GTGAGT/AGTGAA`	1	--	int¹		2		NA EA	240
rs145228851^1,2		--	60765681(+)	`CTGTAC/TAGATG`	1	--	int¹		0	--	--	--	--
rs147654415^1,2		--	60765717(+)	`ATACTA/GCTGTT`	1	--	int¹		0	--	--	--	--
rs115857154^1,2	F,	--	60765803(+)	`TAGCTC/TGTTTG`	1	--	int¹		1		WA	118
rs192642005^1,2		--	60765810(+)	`TTTGCC/TGGCCC`	1	--	int¹		0	--	--	--	--
rs185436601^1,2		--	60765915(+)	`CCTTGA/GTGTTT`	1	--	int¹		0	--	--	--	--
rs116239407^1,2		--	60765945(+)	`CTGCCT/GGTTTC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for BCL2 (60790579 - 60987361 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BCL2
1 CNV: 102690
1 Indel: 60265
Human Gene Mutation Database (HGMD): BCL2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2

DNA2.0 Custom Variant and Variant Library Synthesis for BCL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BCL2 for disorders About GeneDecksing

OMIM gene information: 151430 OMIM disorders: --

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation

t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the

chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide

transitions

20/371 diseases for BCL2 (see all 371): About MalaCards

lymphoma, small cleaved-cell, follicular follicular lymphoma spinal cord injury leukemia/lymphoma, b-cell, 2

estrogen-receptor positive breast cancer li-fraumeni syndrome pelviureteric junction obstruction malignant peripheral nerve sheath tumor

lymphoepithelioma-like carcinoma adenosine deaminase deficiency b-cell non-hodgkin lymphoma natural killer cell leukemia

spinal muscular atrophy fuchs' endothelial dystrophy serous cystadenocarcinoma squamous cell carcinoma

diffuse large b-cell lymphoma human t-cell leukemia virus type 1 hypersensitivity reaction type ii disease non-hodgkin lymphoma

6 diseases from the University of Copenhagen DISEASES database for BCL2:

Lymphoma Leukemia Carcinoma Breast cancer

Vascular disease Lung cancer

10/93 Novoseek disease relationships for BCL2 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma follicular	87.1	381	18945749 (7), 2223650 (5), 18925696 (5), 9349233 (4) (see all 99)
tumors	83.8	3055	2214188 (7), 9002964 (7), 17295204 (6), 15667975 (6) (see all 99)
lymphoma b-cell	82.4	319	18925696 (5), 20459572 (4), 8639245 (3), 9242549 (3) (see all 99)
lymphoma	78.3	595	16373664 (5), 1890741 (5), 11431360 (5), 8371594 (5) (see all 99)
cancer	77.8	713	9416483 (5), 11728179 (5), 9000560 (4), 16531274 (4) (see all 99)
leukemia	74.3	316	18422996 (5), 10456672 (4), 10023011 (4), 20350424 (4) (see all 99)
breast cancer	70.7	671	20068093 (5), 19762066 (5), 11235572 (5), 17288732 (5) (see all 99)
necrosis	69.1	225	10064615 (4), 10464427 (3), 19331832 (3), 10754212 (2) (see all 99)
lymphoma non-hodgkins	68.1	150	15503680 (3), 11380403 (3), 9113013 (3), 1747446 (2) (see all 99)
lymphocytic leukemia chronic b-cell	67.8	31	8104532 (2), 9373241 (1), 17132110 (1), 8260892 (1) (see all 27)

Genatlas disease: BCL2

non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation

t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated lymphoid tissue),with

translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between BCL2 and DCC

Genetic Association Database (GAD): BCL2
Human Genome Epidemiology (HuGE) Navigator: BCL2 (73 documents)
Tumor Gene Database (TGDB): BCL2

Export disorders for BCL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BCL2 gene, integrated from 9 sources (see all 7125):
(articles sorted by number of sources associating them with BCL2)

Utopia: connect your pdf to the dynamic
world of online information

p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. (PubMed id 15849194)^{1, 2, 9} Jin S....Field J. (2005)
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. (PubMed id 10567572)^{1, 2, 9} Yamamoto K.... Korsmeyer S.J. (1999)
Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. (PubMed id 16148027)^{1, 7, 9} Bar-Am O....Youdim M.B. (2005)
Phosphorylation of Bcl2 and regulation of apoptosis. (PubMed id 11368354)^{1, 2, 9} Ruvolo P.P.... May W.S. (2001)
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (PubMed id 11325850)^{1, 4, 9} Tsukasaki K....Koeffler H.P. (2001)
Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. (PubMed id 1339299)^{1, 2, 9} Tanaka S.... Reed J.C. (1992)
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. (PubMed id 2250705)^{1, 2, 9} Hockenbery D.... Korsmeyer S.J. (1990)
Parkin mono-ubiquitinates Bcl-2 and regulates autopha gy. (PubMed id 20889974)^{1, 2} Chen D....Wang G. (2010)
Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (PubMed id 19228691)^{1, 2} Eliseev R.A....Gunter T.E. (2009)
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (PubMed id 18570871)^{1, 2} Wei Y....Levine B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 596	HGNC: 990	AceView: BCL2	Ensembl:ENSG00000171791	euGenes: HUgn596
ECgene: BCL2	Kegg: 596	H-InvDB: BCL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BCL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BCL2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/bcl2/
Wikipedia	http://en.wikipedia.org/wiki/Bcl-2

Intellectual Property for BCL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BCL2 gene:
Search GeneIP for patents involving BCL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2
	EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for BCL2 (Bcl-2)		Browse Cell Culture Products
	ELISAs for BCL2 (Bcl-2)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for BCL2 (Bcl-2)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for BCL2 (Bcl-2)

	OriGene Antibodies for BCL2		OriGene shRNA RFP for BCL2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2
	OriGene Protein Over-expression Lysate for BCL2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for BCL2		OriGene 3'-UTR Clone for BCL2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for BCL2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for BCL2		OriGene Custom Protein Services for BCL2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCL2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2

	GenScript Custom Purified and Recombinant Proteins Services for BCL2		GenScript cDNA clones with any tag delivered in your preferred vector for BCL2
	GenScript Custom Assay Services for BCL2		GenScript Superior Antibodies for BCL2
	GenScript Custom overexpressing Cell Line Services for BCL2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for BCL2 (Bcl-2)

	Regulatory tfbs in BCL2 promoter
	Search Chromatin IP Primers for BCL2
	RT² qPCR Primer Assay in human, mouse, rat BCL2
	GNC Network for BCL2
	SABiosciences PCR Arrays including human, mouse, rat BCL2

Tocris compounds for BCL2

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for BCL2
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays/Drugs for BCL2
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	BCL2 antibodies
	BCL2 proteins

	Antibodies for BCL2
	See all of Abcam's Antibodies, Kits and Proteins for BCL2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for BCL2

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for BCL2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for BCL2
	SwitchGear Promoter luciferase reporter plasmids for BCL2

ThermoFisher Antibody for BCL2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes BCL2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

BCL2 Gene

B-cell CLL/lymphoma 2

Aliases
for BCL2 gene

Summaries
for BCL2 gene

Genomic Views
for BCL2 gene

Proteins
for BCL2 gene

Protein Domains /
Families
for BCL2 gene

Function
for BCL2 gene

Pathways & Interactions
for BCL2 gene

Drugs & Compounds
for BCL2 gene

Transcripts
for BCL2 gene

Expression
for BCL2 gene

Orthologs
for BCL2 gene

Paralogs
for BCL2 gene

Genomic Variants
for BCL2 gene

Disorders / Diseases
for BCL2 gene

Publications
for BCL2 gene

External Searches for BCL2 gene

Genome Databases showing BCL2 gene

Other Databases showing BCL2 gene

Specialized Databases showing BCL2 gene

Intellectual Property
for BCL2 gene

Products
for BCL2 gene

View Random Gene

Leukemia B-Cell
Lymphoma Large Cell
Leukemia T-Cell
Retinoblastoma
Carcinoma Basal Cell
Lymphoma T-Cell
dysplasia
Lymphoma Mantle-Cell
aggressiveness
COLON CARCINOMA
ADENOCARCINOMA LUNG
LUNG CARCINOMA
Lymphoma Follicular
invasive ductal breast carcinoma
Breast Cancer
NSCLC
primary tumor
Lymphoma Small Lymphocytic
Adenocarcinoma
cell damage
Cancer
premalignant
Colorectal Carcinoma
ADENOCARCINOMA GASTRIC
Lymphoma
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
COLON ADENOCARCINOMA
Ovarian Cancer
Colorectal Cancer
HNSCC
Burkitt Lymphoma
Lymphosarcoma
Cervical Cancer
MYELOMA
ENDOMETRIAL CARCINOMA
prostate cancer
Tumors
Metastasis
Carcinoma Ductal
prostatic adenocarcinoma
Necrosis
Lymphoblastic Leukemia Acute
Glioblastoma
salivary gland adenoid cystic carcinoma
Malignant Glioma
neoplastic transformation
lymphoid neoplasm
Gastric Cancer
Diffuse Small Cleaved Cell Lymphoma
Myeloid Leukemia
Neurodegenerative Diseases
BREAST CARCINOMA
Melanoma
bladder cancer
Colon Cancer
promyelocytic leukemia
Leukemia Lymphocytic Chronic
Glioma
Hyperplasia
Carcinoma
Hodgkin Disease
PROSTATE CARCINOMA
Leukemia
epithelial tumor
LARYNGEAL CARCINOMA
Myeloid Leukemia Chronic
Lymphoma Small Cleaved-Cell Follicular
Carcinoma Endometrioid
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
metastatic melanoma
Lymphoma High-Grade
laryngeal squamous cell carcinoma
Pancreatic Cancer
Cancer Lung
small cell lung cancer
Sarcoma Synovial
Lymphoma B-Cell
MALT Lymphoma
NASOPHARYNGEAL CARCINOMA
T-ALL
Adenoma
OVARIAN CARCINOMA
Lymphoproliferative Disorders
Lymphocytic Leukemia Chronic B-Cell
solid tumor
Carcinoma Squamous Cell
Leukemia Promyelocytic Acute
Lymphoma Large Cell Diffuse
Lymphoma Low-Grade
Lymphoma Non-Hodgkins
LEUKAEMIA LYMPHOCYTIC

Advanced Search

Export list of displayed genes

BCL2 Gene

B-cell CLL/lymphoma 2

Aliasesfor BCL2 gene

Summariesfor BCL2 gene

Genomic Viewsfor BCL2 gene

Proteinsfor BCL2 gene

Protein Domains /Familiesfor BCL2 gene

Functionfor BCL2 gene

Pathways & Interactionsfor BCL2 gene

Drugs & Compoundsfor BCL2 gene

Transcriptsfor BCL2 gene

Expression for BCL2 gene

Orthologsfor BCL2 gene

Paralogsfor BCL2 gene

Genomic Variantsfor BCL2 gene

Disorders / Diseasesfor BCL2 gene

Publicationsfor BCL2 gene

External Searches for BCL2 gene

Genome Databases showing BCL2 gene

Other Databases showing BCL2 gene

Specialized Databases showing BCL2 gene

Intellectual Propertyfor BCL2 gene

Productsfor BCL2 gene

View Random Gene

Aliases
for BCL2 gene

Summaries
for BCL2 gene

Genomic Views
for BCL2 gene

Proteins
for BCL2 gene

Protein Domains /
Families
for BCL2 gene

Function
for BCL2 gene

Pathways & Interactions
for BCL2 gene

Drugs & Compounds
for BCL2 gene

Transcripts
for BCL2 gene

Expression
for BCL2 gene

Orthologs
for BCL2 gene

Paralogs
for BCL2 gene

Genomic Variants
for BCL2 gene

Disorders / Diseases
for BCL2 gene

Publications
for BCL2 gene

Intellectual Property
for BCL2 gene

Products
for BCL2 gene