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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL2 Gene

protein-coding GIFtS: 74
GCID: GC18M060763

B-cell CLL/lymphoma 2

Explore 371 diseases affiliated with
BCL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
B-Cell CLL/Lymphoma 2¹ ²
Bcl-2¹ ²
PPP1R50¹ ²
Apoptosis Regulator Bcl-2²
Protein Phosphatase 1, Regulatory Subunit 50²

External Ids:	HGNC: 990¹	Entrez Gene: 596²	Ensembl: ENSG00000171791⁷	OMIM: 151430⁵	UniProtKB: P10415³

Export aliases for BCL2 gene to outside databases

Previous GC identifers: GC18M060629 GC18M058939 GC18M058941 GC18M057487

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2:

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such

as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus,

is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in

their C-terminal ends. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural

cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback

loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the

mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

summary for BCL2:

Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein

family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as

Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2

proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma

and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members

contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial

and other intracellular membranes.

Gene Wiki entry for BCL2 (Bcl-2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL2 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCL2 promoter sequence

Search SABiosciences Chromatin IP Primers for BCL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3

BCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M060763: view genomic region (about GC identifiers)

Start:	60,790,579 bp from pter	End:	60,987,361 bp from pter
Size:	196,783 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415 (See protein sequence)

Recommended Name: Apoptosis regulator Bcl-2

Size: 239 amino acids; 26266 Da

Subunit: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires

intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Interacts with EI24 (By

similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2

to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an

ATP-dependent manner. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts (via the BH4

domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic

activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2

complex. Interacts with BOP

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass

membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein

6/9 PDB 3D structures from and Proteopedia for BCL2 (see all 9):

1G5M (3D)

1GJH (3D)

1YSW (3D)

2O21 (3D)

2O22 (3D)

2O2F (3D)

Secondary accessions: P10416 Q13842 Q16197

Alternative splicing: 2 isoforms: P10415-1 P10415-2

Explore the universe of human proteins at neXtProt for BCL2: NX_P10415

Post-translational modifications:

Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation

on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In

the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and

stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates

starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity)¹

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic

activity, causes the release of cytochrome c into the cytosol promoting further caspase activity¹

Monoubiquitinated by PARK2, leading to increase its stability¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10415

BCL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000624.2 NP_000648.2

ENSEMBL proteins:

ENSP00000381185 ENSP00000329623 ENSP00000466417 ENSP00000404214

Reactome Protein details: P10415
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for BCL2 (Bcl-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: BCL2 OriGene Protein Over-expression Lysate (see all 2): BCL2 OriGene Custom Protein Services for BCL2
	GenScript Custom Purified and Recombinant Proteins Services for BCL2
	Novus Biologicals BCL2 Proteins
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for BCL2
	Browse Proteins at Uscn

Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IDA	7896880
GO:0005737	cytoplasm	IDA	7546744
GO:0005739	mitochondrion	IDA	7896880

BCL2 for ontologies About GeneDecksing

BCL2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BCL2
	R&D Systems Antibodies for BCL2 (Bcl-2)
	Cell Signaling Technology (CST) Antibodies for BCL2 (Bcl-2)
	OriGene Antibodies (see all 4): BCL2 OriGene Custom Antibody Services for BCL2
	GenScript Superior Antibodies for BCL2
	Novus Biologicals BCL2 Antibodies
	Abcam antibodies for BCL2
	Browse Antibodies at Uscn
	ThermoFisher Antibody for BCL2

Assay Products for BCL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for BCL2 (Bcl-2) (see all)
	GenScript Custom Assay Services for BCL2
	Cell Signaling Technology (CST) Sandwich ELISA Kits for BCL2 (Bcl-2)
	Enzo Life Sciences assays for BCL2
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCL2 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR020731 Bcl2_BH4_motif_CS

IPR020728 Bcl2_BH3_motif_CS

IPR003093 Bcl2_BH4

IPR002475 Bcl2-like

IPR026298 Blc2_fam

Graphical View of Domain Structure for InterPro Entry P10415

ProtoNet protein and cluster: P10415

2 Blocks protein families:

IPB000712 Apoptosis regulator Bcl-2 protein

IPB003093 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural

cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback

loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the

mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

Genatlas biochemistry entry for BCL2:

inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by inhibiting the release of

cytochrome from the mitochondrial and by protecting a wide variety of cells including B cells and neuronal

cells,activated by nerve growth factor,mediated by the p42/p44 MAPK cascade,inhibited by phosphorylation mediated by

microtubule-damaging drugs through JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also modulating

CDK2 activation during thymocyte apoptosis,overexpressed in endometrial carcinoma

miRNA Products:		miRTarBase miRNAs that target BCL2: hsa-mir-630 (MIRT005578), hsa-mir-34c-5p (MIRT003979), hsa-mir-16 (MIRT001800), hsa-let-7a (MIRT000418), hsa-mir-181d (MIRT003498), hsa-mir-29b (MIRT003290), hsa-mir-34b (MIRT000065), hsa-mir-181c (MIRT003499), hsa-mir-15b (MIRT000978), hsa-mir-20a (MIRT003011), hsa-mir-15a (MIRT000815), hsa-mir-451 (MIRT005744), hsa-mir-181a (MIRT003501), hsa-mir-204 (MIRT000192), hsa-mir-17 (MIRT003014), hsa-mir-29a (MIRT003291), hsa-mir-21 (MIRT000159), hsa-mir-29c (MIRT003289), hsa-mir-34a (MIRT002298), hsa-mir-195 (MIRT005362), hsa-mir-181b (MIRT003500), hsa-mir-192 (MIRT004844), hsa-mir-153 (MIRT000290)

		OriGene 3'-UTR Clone (see all 2): BCL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCL2
		8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL2 (see all 117):
		hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2 (see all 7) OriGene shRNA RFP: BCL2 OriGene siRNA: BCL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BCL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BCL2 (NM_000633)
		Sino Biological Human cDNA Clone for BCL2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BCL2
		Search LifeMap BioReagents cell lines for BCL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IDA	10620603
GO:0005515	protein binding	IPI	--
GO:0008134	transcription factor binding	IEA	--
GO:0015267	channel activity	IDA	9219694
GO:0019903	protein phosphatase binding	--	--

BCL2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BCL2:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for BCL2: Bcl2^tm1Dlo Bcl2^tm1Sjk Bcl2^tm1Tsu
15/21 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Bcl2) (see all 21):

adipose tissue	cardiovascular system	cellular	craniofacial	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	muscle	nervous system

BCL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/74 super-pathways (see all 74) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/11 pathways (see all 11)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

Development HGF signaling pathway

Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1	0.24	Neurotrophin signaling pathway	0.20
Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1	0.24	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2	0.15
Apoptosis and survival_Role of CDK5 in neuronal death and survival	0.24	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2	0.15
Apoptosis and survival Role of CDK5 in neuronal death and survival	0.24

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	1.00	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins	0.24
Activation of BH3-only proteins	0.30	Intrinsic Pathway for Apoptosis	0.23
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins	0.24	Activation of BAD and translocation to mitochondria	0.15

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

TWEAK Pathway

HIV-1 Nef- Negative effector of Fas and TNF-alpha	0.42	Apoptotic Pathways Triggered By HIV1	0.37
Apoptosis and survival_TNFR1 signaling pathway	0.40	Apoptosis through Death Receptors	0.32
Apoptosis and survival TNFR1 signaling pathway	0.40

Pathway sources
See GeneCards unified pathways
Show all pathways

5/16 EMD Millipore Pathways for BCL2 (see all 16)

	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Development EPO-induced Jak-STAT pathway
	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
	Apoptosis and survival TNFR1 signaling pathway

3 R&D Systems Pathways for BCL2

	IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Apoptosis Signaling Pathways
	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/48 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCL2 (see all 48)

	FLT3 Signaling
	14-3-3 Induced Apoptosis
	IL-4 Pathway
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 Cell Signaling Technology (CST) Pathway for BCL2

Apoptosis and Autophagy

1 Tocris Bioscience Pathway for BCL2

Apoptosis Pathway

5/15 GeneGo (Thomson Reuters) Pathways for BCL2 (see all 15)

	Apoptosis and survival BAD phosphorylation
	Transcription P53 signaling pathway
	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
	Apoptosis and survival FAS signaling cascades

5/30 BioSystems Pathways for BCL2 (see all 30)

	FAS pathway and Stress induction of HSP regulation
	DNA damage response (only ATM dependent)
	Focal Adhesion
	Senescence and Autophagy
	Integrated Breast Cancer Pathway

5/10 Reactome Pathways for BCL2 (see all 10)

	Activation of BH3-only proteins
	Activation of BAD and translocation to mitochondria
	The NLRP1 inflammasome
	Inflammasomes
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

2 PharmGKB Pathways for BCL2

	Busulfan Pathway, Pharmacodynamics
	Vinka Alkaloid Pathway, Pharmacokinetics

5/12 Kegg Pathways (Kegg details for BCL2) (see all 12):

	Protein processing in endoplasmic reticulum
	Apoptosis
	Focal adhesion
	Neurotrophin signaling pathway
	Cholinergic synapse

BCL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BCL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/155 Interacting proteins for BCL2 (P10415^{1, 2, 3} ENSP00000329623⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 155)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53BP2	Q13625²^,³, ENSP00000341957⁴	MINT-7235804 MINT-7235946 MINT-7235823 MINT-7236118 MINT-7236027 MINT-7236079 MINT-7236102 MINT-7236042 MINT-7236003 MINT-7235965 MINT-7235839 MINT-7236061 MINT-7235784 I2D: score=4 STRING: ENSP00000341957
AMBRA1	Q9C0C7²^,³, ENSP00000318313⁴	MINT-8182706 MINT-8182670 MINT-8182688 MINT-8182559 MINT-8182625 MINT-8174974 MINT-8182589 MINT-8182650 MINT-8182607 MINT-8182574 I2D: score=1 STRING: ENSP00000318313
BECN1	Q14457¹^,²^,³, ENSP00000355231⁴	EBI-77694,EBI-949378 MINT-8182780 MINT-4821014 MINT-4820784 MINT-8095220 MINT-8182706 MINT-7014531 MINT-7712827 MINT-8095201 I2D: score=4 STRING: ENSP00000355231
TP53	P04637¹^,²^,³, ENSP00000269305⁴	EBI-77694,EBI-366083 MINT-7291988 MINT-7292025 MINT-7291975 I2D: score=2 STRING: ENSP00000269305
BCL2L11	O43521¹^,²^,³	EBI-77694,EBI-1002160 MINT-6629252 MINT-4980319 I2D: score=12

About this table

Gene Ontology (GO): 154 biological process terms (GO ID links to tree view) (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0000209	protein polyubiquitination	IDA	16717086
GO:0000902	cell morphogenesis	--	--
GO:0001101	response to acid	IEA	--
GO:0001503	ossification	IEA	--
GO:0001541	ovarian follicle development	IEA	--
GO:0001656	metanephros development	IEA	--
GO:0001657	ureteric bud development	--	--
GO:0001658	branching involved in ureteric bud morphogenesis	IEA	--
GO:0001662	behavioral fear response	IEA	--
GO:0001666	response to hypoxia	--	--
GO:0001776	leukocyte homeostasis	--	--
GO:0001782	B cell homeostasis	IEA	--
GO:0001822	kidney development	--	--
GO:0001836	release of cytochrome c from mitochondria	NAS	9027314
GO:0001952	regulation of cell-matrix adhesion	IEA	--
GO:0002260	lymphocyte homeostasis	--	--
GO:0002320	lymphoid progenitor cell differentiation	IEA	--
GO:0002326	B cell lineage commitment	IEA	--
GO:0002360	T cell lineage commitment	--	--
GO:0002520	immune system development	--	--
GO:0003014	renal system process	IEA	--
GO:0006470	protein dephosphorylation	IEA	--
GO:0006582	melanin metabolic process	IEA	--
GO:0006808	regulation of nitrogen utilization	IEA	--
GO:0006874	cellular calcium ion homeostasis	--	--
GO:0006915	apoptotic process	TAS	--
GO:0006950	response to stress	--	--
GO:0006959	humoral immune response	TAS	1908951
GO:0006974	response to DNA damage stimulus	IMP	17875758
GO:0006979	response to oxidative stress	--	--
GO:0007015	actin filament organization	IEA	--
GO:0007409	axonogenesis	--	--
GO:0007420	brain development	--	--
GO:0007565	female pregnancy	NAS	11530860
GO:0007568	aging	--	--
GO:0007569	cell aging	IEA	--
GO:0007584	response to nutrient	--	--
GO:0008219	cell death	IDA	8022822
GO:0008283	cell proliferation	--	--
GO:0008285	negative regulation of cell proliferation	--	--
GO:0008584	male gonad development	IEA	--
GO:0008633	activation of pro-apoptotic gene products	--	--
GO:0009314	response to radiation	NAS	15799693
GO:0009408	response to heat	--	--
GO:0009605	response to external stimulus	IEA	--
GO:0009636	response to toxin	IDA	16307838
GO:0009791	post-embryonic development	IEA	--
GO:0009887	organ morphogenesis	--	--
GO:0010033	response to organic substance	--	--
GO:0010035	response to inorganic substance	--	--
GO:0010039	response to iron ion	IDA	11264898
GO:0010044	response to aluminum ion	--	--
GO:0010224	response to UV-B	IEA	--
GO:0010332	response to gamma radiation	IEA	--
GO:0010468	regulation of gene expression	--	--
GO:0010507	negative regulation of autophagy	TAS	18309324
GO:0010523	negative regulation of calcium ion transport into cytosol	IEA	--
GO:0010559	regulation of glycoprotein biosynthetic process	IEA	--
GO:0014031	mesenchymal cell development	IEA	--
GO:0014042	positive regulation of neuron maturation	IEA	--
GO:0014070	response to organic cyclic compound	--	--
GO:0014911	positive regulation of smooth muscle cell migration	IEA	--
GO:0016049	cell growth	IEA	--
GO:0016337	cell-cell adhesion	IEA	--
GO:0018105	peptidyl-serine phosphorylation	IEA	--
GO:0018107	peptidyl-threonine phosphorylation	IEA	--
GO:0021747	cochlear nucleus development	IEA	--
GO:0022612	gland morphogenesis	IEA	--
GO:0022898	regulation of transmembrane transporter activity	IDA	9219694
GO:0030097	hemopoiesis	--	--
GO:0030183	B cell differentiation	--	--
GO:0030217	T cell differentiation	--	--
GO:0030279	negative regulation of ossification	IEA	--
GO:0030307	positive regulation of cell growth	IDA	8022822
GO:0030308	negative regulation of cell growth	IEA	--
GO:0030318	melanocyte differentiation	IEA	--
GO:0030336	negative regulation of cell migration	IEA	--
GO:0030890	positive regulation of B cell proliferation	IMP	17875758
GO:0031000	response to caffeine	--	--
GO:0031069	hair follicle morphogenesis	IEA	--
GO:0031103	axon regeneration	IEA	--
GO:0031647	regulation of protein stability	IEA	--
GO:0032469	endoplasmic reticulum calcium ion homeostasis	IEA	--
GO:0032835	glomerulus development	IEA	--
GO:0032848	negative regulation of cellular pH reduction	IDA	10506221
GO:0032868	response to insulin stimulus	--	--
GO:0032880	regulation of protein localization	IEA	--
GO:0033033	negative regulation of myeloid cell apoptotic process	IEA	--
GO:0033077	T cell differentiation in thymus	IEA	--
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IEA	--
GO:0033591	response to L-ascorbic acid	--	--
GO:0033689	negative regulation of osteoblast proliferation	IEA	--
GO:0034097	response to cytokine stimulus	IDA	9184696
GO:0034349	glial cell apoptotic process	--	--
GO:0035094	response to nicotine	IDA	12421819
GO:0035265	organ growth	IEA	--
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	TAS	--
GO:0040007	growth	--	--
GO:0040018	positive regulation of multicellular organism growth	IEA	--
GO:0042100	B cell proliferation	IDA	1373874
GO:0042221	response to chemical stimulus	--	--
GO:0042493	response to drug	IMP	17875758
GO:0042542	response to hydrogen peroxide	IEA	--
GO:0042981	regulation of apoptotic process	--	--
GO:0043029	T cell homeostasis	IEA	--
GO:0043066	negative regulation of apoptotic process	IMP	17289999
GO:0043067	regulation of programmed cell death	--	--
GO:0043085	positive regulation of catalytic activity	IEA	--
GO:0043375	CD8-positive, alpha-beta T cell lineage commitment	IEA	--
GO:0043434	response to peptide hormone stimulus	--	--
GO:0043496	regulation of protein homodimerization activity	IDA	9111042
GO:0043497	regulation of protein heterodimerization activity	IDA	9111042
GO:0043524	negative regulation of neuron apoptotic process	IDA	7546744
GO:0043583	ear development	IEA	--
GO:0043627	response to estrogen stimulus	--	--
GO:0045069	regulation of viral genome replication	IEA	--
GO:0045087	innate immune response	TAS	--
GO:0045471	response to ethanol	--	--
GO:0045636	positive regulation of melanocyte differentiation	IEA	--
GO:0045930	negative regulation of mitotic cell cycle	IEA	--
GO:0046671	negative regulation of retinal cell programmed cell death	IEA	--
GO:0046688	response to copper ion	--	--
GO:0046902	regulation of mitochondrial membrane permeability	ISS	9843949
GO:0048041	focal adhesion assembly	IEA	--
GO:0048066	developmental pigmentation	--	--
GO:0048070	regulation of developmental pigmentation	--	--
GO:0048087	positive regulation of developmental pigmentation	--	--
GO:0048536	spleen development	IEA	--
GO:0048538	thymus development	IEA	--
GO:0048545	response to steroid hormone stimulus	--	--
GO:0048546	digestive tract morphogenesis	IEA	--
GO:0048589	developmental growth	IEA	--
GO:0048599	oocyte development	IEA	--
GO:0048709	oligodendrocyte differentiation	--	--
GO:0048743	positive regulation of skeletal muscle fiber development	IEA	--
GO:0048753	pigment granule organization	IEA	--
GO:0048873	homeostasis of number of cells within a tissue	IEA	--
GO:0050790	regulation of catalytic activity	--	--
GO:0050853	B cell receptor signaling pathway	IMP	17875758
GO:0051384	response to glucocorticoid stimulus	IEA	--
GO:0051402	neuron apoptotic process	TAS	16167175
GO:0051412	response to corticosterone stimulus	--	--
GO:0051593	response to folic acid	--	--
GO:0051607	defense response to virus	IDA	10620603
GO:0051726	regulation of cell cycle	--	--
GO:0051881	regulation of mitochondrial membrane potential	ISS	9843949
GO:0051902	negative regulation of mitochondrial depolarization	TAS	9027314
GO:0051924	regulation of calcium ion transport	IDA	8022822
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	15776018
GO:0071310	cellular response to organic substance	IEA	--
GO:0072593	reactive oxygen species metabolic process	IEA	--
GO:2000811	negative regulation of anoikis	IMP	15006356
GO:2001234	negative regulation of apoptotic signaling pathway	IMP	--

BCL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BCL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for BCL2

Compounds for BCL2 available from Tocris Bioscience About this table

Compound	Action	CAS #
2,3-DCPE hydrochloride	Selectively induces cancer cell apoptosis	[418788-90-6]
Gossypol	Pro-apoptotic; downregulates Bcl-2 and Bcl-XL	[303-45-7]
HA14-1	Bcl-2 inhibitor. Induces apoptosis	[65673-63-4]

3 DrugBank Compounds for BCL2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Docetaxel	Docetaxel anhydrous (see all 3)	114977-28-5	target	--	15643508 15161985 15714982 15685445 17674353 15277270
Paclitaxel	7-epi-Paclitaxel (see all 5)	33069-62-4	target	inhibitor	17119350 16741658 17062688 16895478 17230521
Rasagiline	--	136236-51-6	target	activator	12057839 14555244 16148027 12043833 12200198

10/126 Novoseek chemical compound relationships for BCL2 gene (see all 126) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
genasense	81.3	45	16584297 (3), 16564596 (3), 11751483 (2), 12393493 (1) (see all 24)
noxa	75.3	52	19372561 (3), 17018621 (3), 16673057 (2), 19540835 (2) (see all 34)
dutp	75.2	39	9212738 (1), 11920781 (1), 12210368 (1), 14761612 (1) (see all 38)
adpribose	71.7	49	12490780 (2), 11328292 (1), 11896536 (1), 18767861 (1) (see all 44)
paclitaxel	71.3	393	9716607 (8), 9699642 (7), 19671798 (6), 10097113 (6) (see all 99)
etoposide	68.8	137	10367743 (4), 8752171 (4), 9554589 (4), 8395979 (4) (see all 86)
doxorubicin	66.8	175	8781438 (6), 12579337 (3), 18498876 (3), 19818735 (3) (see all 96)
oridonin	66.3	15	17260801 (3), 15008459 (2), 15703811 (2), 16638644 (1) (see all 10)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide	66.1	6	12144824 (1), 15033191 (1), 18471799 (1), 15749633 (1) (see all 6)
paraffin	65.4	126	9343323 (4), 9521469 (1), 10652623 (1), 10491515 (1) (see all 99)

Search CenterWatch for drugs/clinical trials and news about BCL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BCL2 gene (2 alternative transcripts):

NM_000633.2 NM_000657.2

Unigene Cluster for BCL2:

B-cell CLL/lymphoma 2

Hs.150749 [show with all ESTs]

Unigene Representative Sequence: NM_000633

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000398117(uc002liu.1) ENST00000333681(uc002lit.1) ENST00000590515

ENST00000589955 ENST00000444484(uc002liv.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BCL2 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-323-3p hsa-miR-607 hsa-miR-1307 hsa-miR-15a hsa-miR-605 hsa-miR-632 hsa-miR-30d hsa-miR-550a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AF401211.1 BC027258.1 EU287875.1 M13994.1 M13995.1 M14745.1 X06487.1

4 DOTS entries:

DT.216205 DT.100749960 DT.86998979 DT.40316825

24/148 AceView cDNA sequences (see all 148):

AA321638 F04196 BQ224622 AF401211 BG503428 BF222234 BM986952 BM973833

AI261915 W61100 AI391699 BE503573 F07940 BE550816 AL703462 BM463468

AI627828 N42615 BC027258 BM996398 N29770 AI480094 CB118071 AI142026

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2 About this scheme

ExUns:	1a	·	1b	^	2	^	3
SP1:
SP2:

ECgene alternative splicing isoforms for BCL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTGGAGA

About this image

BCL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

White adipocyte-like cells (Differentiation of w...)

Brown adipocyte-like cells (Differentiation of w...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BCL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL2

SOURCE GeneReport for Unigene cluster: Hs.150749

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Tissue specificity: Expressed in a variety of tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2 (see all 34):

Neurogenesis in human mouse rat

Lung Cancer in human mouse rat

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

Inflammasomes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BCL2 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BCL2¹	B-cell CLL/lymphoma 2	75.51(n) 77.39(a)		396282 NM_205339.1 NP_990670.1
lizard (Anolis carolinensis)	Reptilia	BCL2⁶	--	70(a)	1 ↔ 1	GL344304.1(26465-27025)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-217f4.3⁶ CU695001.1⁶	--	49(a) 46(a)	1 ↔ many 1 ↔ many	2(12979720-13007658) 24(29060361-29151442)

ENSEMBL Gene Tree for BCL2 (if available)
TreeFam Gene Tree for BCL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BCL2 gene

BAK1² BCL2L2² BCL2L1² BAX²

4 SIMAP similar genes for BCL2 using alignment to 3 protein entries: BCL2_HUMAN (see all proteins):

bcl-2 BCL2L2-PABPN1 BCL2L2 BCL2L1

BCL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35275357^1,2	C	--	57648853(+)	`CTAAT-/TTAG TTGTT`	1	--	int¹		0	--	--	--	--
rs188357713^1,2		--	60765382(+)	`TGGGGA/GGATGC`	1	--	int¹		0	--	--	--	--
rs4940570^1,2	C,F,	--	60765568(+)	`ATTTCA/GGGATT`	1	--	int¹		3		WA NA EA	358
rs72939458^1,2	C,F,	--	60765648(+)	`GTGAGT/AGTGAA`	1	--	int¹		2		NA EA	240
rs145228851^1,2		--	60765681(+)	`CTGTAC/TAGATG`	1	--	int¹		0	--	--	--	--
rs147654415^1,2		--	60765717(+)	`ATACTA/GCTGTT`	1	--	int¹		0	--	--	--	--
rs115857154^1,2	F,	--	60765803(+)	`TAGCTC/TGTTTG`	1	--	int¹		1		WA	118
rs192642005^1,2		--	60765810(+)	`TTTGCC/TGGCCC`	1	--	int¹		0	--	--	--	--
rs185436601^1,2		--	60765915(+)	`CCTTGA/GTGTTT`	1	--	int¹		0	--	--	--	--
rs116239407^1,2		--	60765945(+)	`CTGCCT/GGTTTC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for BCL2 (60790579 - 60987361 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BCL2
1 CNV: 102690
1 Indel: 60265
Human Gene Mutation Database (HGMD): BCL2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2

DNA2.0 Custom Variant and Variant Library Synthesis for BCL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BCL2 for disorders About GeneDecksing

OMIM gene information: 151430 OMIM disorders: --

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation

t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the

chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide

transitions

20/371 diseases for BCL2 (see all 371): About MalaCards

lymphoma, small cleaved-cell, follicular follicular lymphoma spinal cord injury leukemia/lymphoma, b-cell, 2

estrogen-receptor positive breast cancer li-fraumeni syndrome pelviureteric junction obstruction malignant peripheral nerve sheath tumor

lymphoepithelioma-like carcinoma adenosine deaminase deficiency b-cell non-hodgkin lymphoma natural killer cell leukemia

spinal muscular atrophy fuchs' endothelial dystrophy serous cystadenocarcinoma squamous cell carcinoma

diffuse large b-cell lymphoma human t-cell leukemia virus type 1 hypersensitivity reaction type ii disease non-hodgkin lymphoma

6 diseases from the University of Copenhagen DISEASES database for BCL2:

Lymphoma Leukemia Carcinoma Breast cancer

Vascular disease Lung cancer

10/93 Novoseek disease relationships for BCL2 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma follicular	87.1	381	18945749 (7), 2223650 (5), 18925696 (5), 9349233 (4) (see all 99)
tumors	83.8	3055	2214188 (7), 9002964 (7), 17295204 (6), 15667975 (6) (see all 99)
lymphoma b-cell	82.4	319	18925696 (5), 20459572 (4), 8639245 (3), 9242549 (3) (see all 99)
lymphoma	78.3	595	16373664 (5), 1890741 (5), 11431360 (5), 8371594 (5) (see all 99)
cancer	77.8	713	9416483 (5), 11728179 (5), 9000560 (4), 16531274 (4) (see all 99)
leukemia	74.3	316	18422996 (5), 10456672 (4), 10023011 (4), 20350424 (4) (see all 99)
breast cancer	70.7	671	20068093 (5), 19762066 (5), 11235572 (5), 17288732 (5) (see all 99)
necrosis	69.1	225	10064615 (4), 10464427 (3), 19331832 (3), 10754212 (2) (see all 99)
lymphoma non-hodgkins	68.1	150	15503680 (3), 11380403 (3), 9113013 (3), 1747446 (2) (see all 99)
lymphocytic leukemia chronic b-cell	67.8	31	8104532 (2), 9373241 (1), 17132110 (1), 8260892 (1) (see all 27)

Genatlas disease: BCL2

non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation

t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated lymphoid tissue),with

translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between BCL2 and DCC

Genetic Association Database (GAD): BCL2
Human Genome Epidemiology (HuGE) Navigator: BCL2 (73 documents)
Tumor Gene Database (TGDB): BCL2

Export disorders for BCL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BCL2 gene, integrated from 9 sources (see all 7125):
(articles sorted by number of sources associating them with BCL2)

Utopia: connect your pdf to the dynamic
world of online information

p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. (PubMed id 15849194)^{1, 2, 9} Jin S....Field J. (2005)
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. (PubMed id 10567572)^{1, 2, 9} Yamamoto K.... Korsmeyer S.J. (1999)
Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. (PubMed id 16148027)^{1, 7, 9} Bar-Am O....Youdim M.B. (2005)
Phosphorylation of Bcl2 and regulation of apoptosis. (PubMed id 11368354)^{1, 2, 9} Ruvolo P.P.... May W.S. (2001)
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (PubMed id 11325850)^{1, 4, 9} Tsukasaki K....Koeffler H.P. (2001)
Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. (PubMed id 1339299)^{1, 2, 9} Tanaka S.... Reed J.C. (1992)
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. (PubMed id 2250705)^{1, 2, 9} Hockenbery D.... Korsmeyer S.J. (1990)
Parkin mono-ubiquitinates Bcl-2 and regulates autopha gy. (PubMed id 20889974)^{1, 2} Chen D....Wang G. (2010)
Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. (PubMed id 19228691)^{1, 2} Eliseev R.A....Gunter T.E. (2009)
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (PubMed id 18570871)^{1, 2} Wei Y....Levine B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 596	HGNC: 990	AceView: BCL2	Ensembl:ENSG00000171791	euGenes: HUgn596
ECgene: BCL2	Kegg: 596	H-InvDB: BCL2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BCL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BCL2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/bcl2/
Wikipedia	http://en.wikipedia.org/wiki/Bcl-2

Intellectual Property for BCL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BCL2 gene:
Search GeneIP for patents involving BCL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	OriGene Antibodies for BCL2		OriGene shRNA RFP for BCL2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCL2
	OriGene Protein Over-expression Lysate for BCL2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for BCL2		OriGene 3'-UTR Clone for BCL2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCL2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for BCL2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for BCL2		OriGene Custom Protein Services for BCL2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCL2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCL2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCL2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCL2

	GenScript Custom Purified and Recombinant Proteins Services for BCL2		GenScript cDNA clones with any tag delivered in your preferred vector for BCL2
	GenScript Custom Assay Services for BCL2		GenScript Superior Antibodies for BCL2
	GenScript Custom overexpressing Cell Line Services for BCL2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for BCL2 (Bcl-2)

	Regulatory tfbs in BCL2 promoter
	Search Chromatin IP Primers for BCL2
	RT² qPCR Primer Assay in human, mouse, rat BCL2
	GNC Network for BCL2
	SABiosciences PCR Arrays including human, mouse, rat BCL2

Tocris compounds for BCL2

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for BCL2
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays/Drugs for BCL2
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	BCL2 antibodies
	BCL2 proteins

	Antibodies for BCL2
	See all of Abcam's Antibodies, Kits and Proteins for BCL2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for BCL2

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for BCL2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for BCL2
	SwitchGear Promoter luciferase reporter plasmids for BCL2

ThermoFisher Antibody for BCL2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCL2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes BCL2 gene at Home site.

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BCL2 Gene

B-cell CLL/lymphoma 2

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Leukemia B-Cell
Lymphoma Large Cell
Leukemia T-Cell
Retinoblastoma
Carcinoma Basal Cell
Lymphoma T-Cell
dysplasia
Lymphoma Mantle-Cell
aggressiveness
COLON CARCINOMA
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LUNG CARCINOMA
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invasive ductal breast carcinoma
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cell damage
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epithelial tumor
LARYNGEAL CARCINOMA
Myeloid Leukemia Chronic
Lymphoma Small Cleaved-Cell Follicular
Carcinoma Endometrioid
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
metastatic melanoma
Lymphoma High-Grade
laryngeal squamous cell carcinoma
Pancreatic Cancer
Cancer Lung
small cell lung cancer
Sarcoma Synovial
Lymphoma B-Cell
MALT Lymphoma
NASOPHARYNGEAL CARCINOMA
T-ALL
Adenoma
OVARIAN CARCINOMA
Lymphoproliferative Disorders
Lymphocytic Leukemia Chronic B-Cell
solid tumor
Carcinoma Squamous Cell
Leukemia Promyelocytic Acute
Lymphoma Large Cell Diffuse
Lymphoma Low-Grade
Lymphoma Non-Hodgkins
LEUKAEMIA LYMPHOCYTIC

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Export list of displayed genes

BCL2 Gene

B-cell CLL/lymphoma 2

Aliasesfor BCL2 gene

Summariesfor BCL2 gene

Genomic Viewsfor BCL2 gene

Proteinsfor BCL2 gene

Protein Domains /Familiesfor BCL2 gene

Functionfor BCL2 gene

Pathways & Interactionsfor BCL2 gene

Drugs & Compoundsfor BCL2 gene

Transcriptsfor BCL2 gene

Expression for BCL2 gene

Orthologsfor BCL2 gene

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Genomic Variantsfor BCL2 gene

Disorders / Diseasesfor BCL2 gene

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Genome Databases showing BCL2 gene

Other Databases showing BCL2 gene

Specialized Databases showing BCL2 gene

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for BCL2 gene

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for BCL2 gene

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for BCL2 gene

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for BCL2 gene

Function
for BCL2 gene

Pathways & Interactions
for BCL2 gene

Drugs & Compounds
for BCL2 gene

Transcripts
for BCL2 gene

Expression
for BCL2 gene

Orthologs
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for BCL2 gene

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Products
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