Aliases for BCL2 Gene
External Ids for BCL2 Gene
Previous GeneCards Identifiers for BCL2 Gene
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL2 Gene
BCL2 (B-Cell CLL/Lymphoma 2) is a Protein Coding gene. Diseases associated with BCL2 include follicular lymphoma and intravascular large b-cell lymphoma. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is BAK1.
UniProtKB/Swiss-Prot for BCL2 Gene
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.