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BCL2 Gene

protein-coding GIFtS: 76

GC18M058941

B-cell CLL/lymphoma 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Bcl-2 ^¹, ²
OTTHUMP00000163680 ^²

Descriptions
B-cell CLL/lymphoma 2 ^²
B-cell lymphoma protein 2 ^²

External Ids
HGNC: 990¹
Entrez Gene: 596²
UniProtKB: P10415³
Ensembl: ENSG00000171791⁷

Search outside databases for aliases for BCL2 gene

Previous GC identifers: GC18M060629 GC18M060763 GC18M058939

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BCL2:

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death

of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of

translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.

Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

[provided by RefSeq]

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent

lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial

membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits

caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by

binding to the apoptosis-activating factor (APAF-1)

Gene Wiki entry for BCL2 (Bcl-2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BCL2 gene

Entrez Gene cytogenetic band: 18q21.33|18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3

BCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M058941: (about GC identifiers)

Start:	58,941,559 bp from pter
End:	59,138,341 bp from pter
Size:	196,783 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_025028.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415 (See protein sequence)

Recommended Name: Apoptosis regulator Bcl-2

Size: 239 amino acids; 26266 Da

Subunit: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization

with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By

similarity). Also interacts with APAF1, RAF-1, TP53BP2, BBC3, BCL2L1, MRPL41 and BNIPL. Binding to

FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to

its targets

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane;

Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein

PDB structures from and Proteopedia :

1G5M (3D)

1GJH (3D)

1YSW (3D)

2O21 (3D)

2O22 (3D)

2O2F (3D)

2W3L (3D)

Secondary accessions: P10416 Q13842 Q16197

Alternative splicing: 2 isoforms: P10415-1 P10415-2

Post-translational modifications:

Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth

factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and

occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to

be phosphorylated by other protein kinases such as ERKs and stress-activated kinases.

Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity)¹

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif,

has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further

caspase activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000624.2 NP_000648.2

ENSEMBL proteins:

ENSP00000381185 ENSP00000329623

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for BCL2
	R&D Systems Recombinant & Natural Proteins for BCL2 (Bcl-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bcl2 alpha, Bcl2)
	Human Recombinant Proteins from Abnova (BCL2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/16 Gene Ontology (GO) cellular component terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000159	protein phosphatase type 2A complex	IEA	--
GO:0005622	intracellular	IEA	--
GO:0005624	membrane fraction	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	11530860

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Antibodies for BCL2:

	Invitrogen Antibodies for BCL2
	Millipore Mono- and Polyclonal Antibodies for the study of BCL2
	Sigma-Aldrich Antibody Arrays and Antibodies for BCL2
	R&D Systems Antibodies for BCL2 (Bcl-2)
	Cell Signaling Technology (CST) Antibodies for BCL2 (Bcl-2)
	Antibodies from Abcam (Bcl2 alpha, Bcl2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BCL2)
	Novus Biologicals Antibodies for BCL2

Assays for BCL2:

	Invitrogen Assays for BCL2
	Millipore Kits and Assays for the Analysis of BCL2
	R&D Systems ELISAs for BCL2 (Bcl-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10415

ProtoNet protein and cluster: P10415

2 Blocks protein families:

IPB000712 Apoptosis regulator Bcl-2 protein

IPB003093 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1

Similarity: Belongs to the Bcl-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL2)
		Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BCL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000657

Applied Biosystems Silencer® siRNAs for BCL2

Sigma-Aldrich siRNA and siRNA Panels for BCL2

Sigma-Aldrich shRNA Panels and shRNA for BCL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BCL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000633
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000633
untagged cDNA clones in CMV expression vector (see all 3): BC027258

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC027258

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent

lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial

membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits

caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by

binding to the apoptosis-activating factor (APAF-1)

Genatlas biochemistry entry for BCL2:

inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by

inhibiting the release of cytochrome from the mitochondrial and by protecting a wide variety of

cells including B cells and neuronal cells,activated by nerve growth factor,mediated by the

p42/p44 MAPK cascade,inhibited by phosphorylation mediated by microtubule-damaging drugs through

JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also modulating CDK2 activation

during thymocyte apoptosis,overexpressed in endometrial carcinoma

15/20 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Bcl2) (see all 20 ):

	craniofacial	digestive/alimentary	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
life span-post-weaning/aging	muscle	nervous system	pigmentation	renal/urinary system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IDA	10620603
GO:0008134	transcription factor binding	IEA	--
GO:0016563	transcription activator activity	IEA	--
GO:0042803	protein homodimerization activity	IDA	9111042
GO:0046982	protein heterodimerization activity	IPI	9111042

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/20 Sigma-Aldrich "Your Favorite Gene" Pathways for BCL2 (Your Favorite Gene powered by Ingenuity) (see all 20 )

Melanocyte Development and Pigmentation Signaling
Glucocorticoid Receptor Signaling
PI3K/AKT Signaling
Apoptosis Signaling
Type I Diabetes Mellitus Signaling

GeneDecks BCL2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BCL2

5/410 Interacting proteins for BCL2 (ENSP00000329623³ P10415^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 410 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAD	Q92934¹	STRING (score=.999) EBI-77694, EBI-700771
BBC3	Q9BXH1¹	STRING (score=.999) EBI-77694, EBI-519884
BCAP31	P51572¹	STRING (score=.969) EBI-77694, EBI-77683
BID	P55957¹	STRING (score=.999) EBI-77694, EBI-519672
BIK	Q13323¹	STRING (score=.999) EBI-77694, EBI-700794

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5/104 Gene Ontology (GO) biological process terms (links to tree view) (see all 104 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0000902	cell morphogenesis	IEA	--
GO:0001101	response to acid	IEA	--
GO:0001541	ovarian follicle development	IEA	--
GO:0001658	ureteric bud branching	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for BCL2

Sigma-Aldrich Small Molecules for BCL2:

Antagonist Ligand

Compounds for BCL2 available from Tocris Bioscience

Compound	Action	CAS number
2,3-DCPE hydrochloride	Selectively induces cancer cell apoptosis	[418788-90-6]
Gossypol	Pro-apoptotic; downregulates Bcl-2 and Bcl-XL	[303-45-7]
Anti-Bcl-2	Antibody recognizing Bcl-2
HA14-1	Bcl-2 inhibitor. Induces apoptosis	[65673-63-4]

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10/24 Novoseek chemical compound relationships for BCL2 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
genasense	81.15	42	16584297 (3), 16564596 (3), 11751483 (2), 12393493 (1) (see all 22)
dutp	75.16	34	9212738 (1), 11920781 (1), 12210368 (1), 14761612 (1) (see all 33)
noxa	73.70	41	19372561 (3), 17018621 (3), 16673057 (2), 17283153 (2) (see all 25)
oridonin	64.62	15	17260801 (3), 15008459 (2), 15703811 (2), 16638644 (1) (see all 10)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide	63.80	6	12144824 (1), 15033191 (1), 18471799 (1), 15749633 (1) (see all 6)
sp 600125	62.44	12	16167336 (1), 18695917 (1), 16420771 (1), 16149076 (1) (see all 10)
ptpc	61.79	7	11212328 (1), 10645010 (1), 10739647 (1), 12022943 (1) (see all 7)
gambogic acid	61.66	13	19379569 (2), 19200201 (2), 17693016 (1), 18298900 (1) (see all 9)
ceramide	61.35	133	8643573 (5), 16297852 (5), 10400650 (5), 9841888 (5) (see all 64)
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carb oxylate	60.77	2	14966123 (1), 16510597 (1)

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2 PharmGKB drug compound relationships for BCL2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
cyclosporin a	FA	12086014
flavopiridol	FA	12170773

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCL2)
		Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BCL2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000657

Sigma-Aldrich siRNA and siRNA Panels for BCL2

Sigma-Aldrich shRNA Panels and shRNA for BCL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000633 NM_000657

REFSEQ mRNAs for BCL2 gene (2 alternative transcripts):

NM_000633.2 NM_000657.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000633 NM_000657

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000633
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000633
                                 untagged cDNA clones in CMV expression vector (see all 3): BC027258

Additional cDNA sequence:

AF401211.1 BC027258.1 EU287875.1 M13994.1 M13995.1 M14745.1 X06487.1

4 DOTS entries:

DT.216205 DT.100749960 DT.86998979 DT.40316825

24/148 AceView cDNA sequences (see all 148 ):

N42615 BQ215366 AL703462 BM463468 BM973833 BM996398 BE550816 AI391699

F04196 AW241434 AF401211 BQ224622 BC027258 W61100 BU195508 AI261915

AI480094 BG388287 BU159596 BG503428 AI142026 AU135900 AI627828 N29770

highest scoring ESTs for BCL2:

AW364524 AW468867 BC027258 BE675587 BE832371 BE935192 BF516456 BQ054417 BQ055296 BQ055950

Unigene Cluster for BCL2:

B-cell CLL/lymphoma 2

Hs.150749 [show with all ESTs]

Unigene Representative Sequence: NM_000633

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2

ExUns:	1a	·	1b	^	2	^	3
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for BCL2

2 Ensembl transcripts including schematic representations:

ENST00000398117 ENST00000333681

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BCL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCL2

¹ / ² / ³

13 probe-sets matching BCL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2060_at²^{, 3}	U95-A	1	1.00	1.00	0.40	0.89	M13995	0.60	1.00	0.82	1
1847_s_at²^{, 3}	U95-A	1	1.00	1.00	0.62	0.64	M13994	0.80	1.00	0.91	1
1910_s_at²^{, 3}	U95-A	1	1.00	1.00	0.28	1.11	M14745	0.60	1.00	0.82	1
1909_at²^{, 3}	U95-A	1	1.00	1.00	0.63	1.29	M14745	0.60	1.00	0.82	1
2038_g_at²^{, 3}	U95-A	1	1.00	1.00	0.58	1.11	M13995	0.60	1.00	0.82	1
203685_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000633	0.60	1.00	0.82	1
207005_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000657	0.60	1.00	0.82	1
207004_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000657	0.60	1.00	0.82	1
203684_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M13994	0.80	1.00	0.91	1
203685_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207005_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207004_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203684_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BCL2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTGTGGAGA

SOURCE GeneReport for Unigene cluster: Hs.150749
Expression variation in blood from EXPOLDB for BCL2
UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415
Tissue specificity: Expressed in a variety of tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BCL2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCL2¹	--	B-cell CLL/lymphoma 2	90.79(n) 89.54(a)	403416 NM_001002949.1 NP_001002949.1
chimpanzee (Pan troglodytes)	BCL2¹	--	B-cell CLL/lymphoma 2	100(n) 100(a)	738409 XM_001145537.1 XP_001145537.1
cow (Bos taurus)	BCL2¹	--	B-cell CLL/lymphoma 2	91.56(n) 94.76(a)	281020 XM_586976.3 XP_586976.3
rat (Rattus norvegicus)	Bcl2¹	--	B-cell CLL/lymphoma 2	88.56(n) 89.41(a)	24224 NM_016993.1 NP_058689.1
mouse (Mus musculus)	Bcl2^{1, 5}	1 (59.80 cM)⁵	B-cell leukemia/lymphoma 2^{1, 5}	88.98(n)¹ 91.53(a)¹	12043¹ NM_009741.3¹ NP_033871.2¹ AA387478⁵ AA867214⁵ (see all 20)

About this table Species with no ortholog for BCL2

ENSEMBL Gene Tree for BCL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BCL2 gene

BCL2L7P1² BCL2L2² BCL2L1² BAX²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1097 NCBI SNPs in BCL2 are shown (see all 1097 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 466)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1564483^1,2	A,C,F,H,O	58945634(-)	`GCCACA/GACCCT`	1	--	ut3¹ ese³		19	MN EU EA WA NS NA	3048
	rs4987853^1,2	A,C,F,H	58944635(-)	`ATGGCA/GAATGA`	1	--	ut3¹		26	NS EU EA WA NA	2654
	rs1016860^1,2	A,C,F,H	58946054(-)	`CTTAAA/GCCCTG`	1	--	ut3¹		16	NA MN EU EA WA NS	1658
	rs1893806^1,2	A,C,F,H	59135944(-)	`AGCTTG/TTTGGA`	2	--	ng5¹ int¹		16	EA NA MN EU WA NS	1594
	rs4987861^1,2	C,F,H	58943544(-)	`GAAAAC/TTCTGG`	1	--	ut3¹ ese³		14	NS EU EA WA NA	1394
	rs4987852^1,2	C,F,H	58944901(-)	`TTCTGA/GGAAGG`	1	--	ut3¹ ese³		16	NS EU EA WA NA	1560
	rs1473418^1,2	C,F,H	59137529(-)	`TCCCCC/GCGACT`	2	--	ut5¹ ese³		9	NA EA MN EU WA NS	1026
	rs4987855^1,2	C,F,H	58944529(-)	`TCCGCG/AGGGGC`	1	--	ut3¹ ese³		12	NS EU EA WA NA	1120
--	rs1800477^1,2	C,F,H	59136753(-)	`gggccG/Accccc`	2	T/A	mis¹ ese³		5	NS EU EA WA	568
	rs4987859^1,2	C,F,H	58943637(-)	`CCCTCG/ACTGCA`	1	--	ut3¹ ese³		14	NS NA EU EA WA	1396

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HapMap Linkage Disequilibrium images for BCL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 151430

UniProtKB/Swiss-Prot: BCL2_HUMAN, P10415

A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL)

[MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14;18)(q32;q21)

with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the

chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting

in nucleotide transitions

10/93 Novoseek disease relationships for BCL2 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma follicular	87.60	370	18945749 (7), 2223650 (5), 18925696 (5), 9349233 (4) (see all 99)
tumors	83.30	2889	2214188 (7), 9002964 (7), 17295204 (6), 15667975 (6) (see all 99)
lymphoma b-cell	81.91	253	18925696 (5), 8639245 (3), 8106752 (3), 18367485 (3) (see all 99)
lymphoma	78.21	567	16373664 (5), 1890741 (5), 11431360 (5), 8371594 (5) (see all 99)
cancer	76.72	668	9416483 (5), 11728179 (5), 9000560 (4), 16531274 (4) (see all 99)
leukemia	73.08	285	18422996 (5), 10456672 (4), 10023011 (4), 14689061 (3) (see all 99)
breast cancer	69.35	626	11235572 (5), 17626754 (5), 17288732 (5), 17352236 (4) (see all 99)
necrosis	68.55	212	10064615 (4), 10464427 (3), 10754212 (2), 14646554 (2) (see all 99)
lymphoma non-hodgkins	68.37	146	15503680 (3), 11380403 (3), 9113013 (3), 1747446 (2) (see all 99)
lymphocytic leukemia chronic b-cell	67.72	29	8104532 (2), 9373241 (1), 17132110 (1), 8260892 (1) (see all 26)

About this table

Genatlas disease: BCL2

non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation

t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated

lymphoid tissue),with translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between

BCL2 and DCC

Human Gene Mutation Database: BCL2
Genetic Association Database: BCL2
Human Genome Epidemiology Navigator: BCL2 (31 documents)
Tumor Gene Database: BCL2
Breast Cancer Gene Database: BCL2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/5516 PubMed articles for BCL2 gene (see all 5516 ):

Phosphorylation of Bcl2 and regulation of apoptosis. (PubMed id 11368354)^{1, 3, 4} Ruvolo P.P.... May W.S. (2001)
Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (PubMed id 11325850)^{1, 3, 6} Tsukasaki K....Koeffler H.P. (2001)
Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. (PubMed id 1339299)^{1, 3, 4} Tanaka S.... Reed J.C. (1992)
Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression. (PubMed id 17090549)^{3, 4} Portier B.P. and Taglialatela G. (2006)
The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). (PubMed id 15733859)^{3, 4} Kang C.B.... Yoon H.S. (2005)
BMRP is a Bcl-2 binding protein that induces apoptosis. (PubMed id 15547950)^{3, 4} Chintharlapalli S.R.... Gonzalez-Garcia M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association between glutathione S-transferase genotypes and Hodgkin's lymphoma risk and prognosis. (PubMed id 12960134)^{3, 6} Hohaus S....Leone G. (2003)
Sequence-based polymorphisms in members of the apoptosis Bcl-2 gene family and their association with hematocrit level. (PubMed id 14714449)^{3, 6} Zeng S.M....Strauss R.G. (2003)
BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PubMed id 12901880)^{3, 4} Qin W.... Gu J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 596	HGNC: 990	AceView: BCL2	Ensembl:ENSG00000171791	euGenes: HUgn596
ECgene: BCL2	H-InvDB: BCL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BCL2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/bcl2/
Wikipedia	http://en.wikipedia.org/wiki/Bcl-2

Licensable Technologies for BCL2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BCL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BCL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BCL2		Antibodies for BCL2
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	Lentivirus-delivered shRNAs for BCL2		Small molecules for BCL2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BCL2)
	Antibodies (BCL2)
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Antibodies & Assays for BCL2 (Bcl-2)

	Recombinant Proteins (Bcl2 alpha, Bcl2)
	Antibodies (Bcl2 alpha, Bcl2)

Search OriGene for BCL2

Tocris compounds for BCL2

	Drugs for BCL2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BCL2

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BCL2 Gene

protein-coding GIFtS: 76

Aliases &
Descriptions
for BCL2

Summaries
for BCL2

Genomic Location
for BCL2

Proteins
for BCL2

Protein Domains/
Families
for BCL2

Gene Function
for BCL2

Pathways & Interactions
for BCL2

Drugs & Compounds
for BCL2

Transcripts
for BCL2

Expression
for BCL2

Orthologs
for BCL2

Paralogs
for BCL2

SNPs/Variants
for BCL2

Disorders & Mutations
for BCL2

Medical News
for BCL2

Publications
for BCL2

Search for BCL2

Genome Databases showing BCL2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BCL2 Gene

protein-coding GIFtS: 76

Aliases & Descriptionsfor BCL2

Summariesfor BCL2

Genomic Locationfor BCL2

Proteinsfor BCL2

Protein Domains/Familiesfor BCL2

Gene Functionfor BCL2

Pathways & Interactionsfor BCL2

Drugs & Compoundsfor BCL2

Transcriptsfor BCL2

Expression for BCL2

Orthologsfor BCL2

Paralogsfor BCL2

SNPs/Variantsfor BCL2

Disorders & Mutationsfor BCL2

Medical Newsfor BCL2

Publicationsfor BCL2

Search for BCL2

Genome Databases showing BCL2

Other Databases showing BCL2

Specialized Databases showing BCL2

Licensable Technologiesfor BCL2

Servicesfor BCL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BCL2

Summaries
for BCL2

Genomic Location
for BCL2

Proteins
for BCL2

Protein Domains/
Families
for BCL2

Gene Function
for BCL2

Pathways & Interactions
for BCL2

Drugs & Compounds
for BCL2

Transcripts
for BCL2

Expression
for BCL2

Orthologs
for BCL2

Paralogs
for BCL2

SNPs/Variants
for BCL2

Disorders & Mutations
for BCL2

Medical News
for BCL2

Publications
for BCL2

Licensable Technologies
for BCL2

Services
for BCL2