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BCL11B Gene

protein-coding   GIFtS: 53
GCID: GC14M099635

B-Cell CLL/Lymphoma 11B (Zinc Finger Protein)


(Previous symbol: ZNF856B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B-Cell CLL/Lymphoma 11B (Zinc Finger Protein)1 2     ATL1-delta2
CTIP22 3 5     ATL1-gamma2
ZNF856B1 2     CTIP-22
Radiation-Induced Tumor Suppressor Gene 1 Protein2 3     B-Cell CLL/Lymphoma 11B/T-Cell Receptor Delta Constant Region Fusion
Protein2
BCL-11B2 3     B-Cell Lymphoma/Leukaemia 11B2
RIT12 3     B-Cell Lymphoma/Leukemia 11B2
COUP-TF-Interacting Protein 22 3     BCL11B/TRDC Fusion2
hRit12 3     hRIT1-alpha2
ATL12     Zinc Finger Protein HRit1 Alpha2
ATL1-alpha2     B-Cell CLL/Lymphoma 11B3
ATL1-beta2     

External Ids:    HGNC: 132221   Entrez Gene: 649192   Ensembl: ENSG000001271527   OMIM: 6065585   UniProtKB: Q9C0K03   

Export aliases for BCL11B gene to outside databases

Previous GC identifers: GC14M097147 GC14M093451 GC14M097625 GC14M098705 GC14M079819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCL11B Gene:
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may
be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the
encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling
and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have
been found for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for BCL11B Gene:
BCL11B (B-cell CLL/lymphoma 11B (zinc finger protein)) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is BCL11A.

UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0
Function: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be
a key regulator of both differentiation and survival during thymocyte development. Repress transcription through
direct, TFCOUP2-independent binding to a GC-rich response element (By similarity)

Gene Wiki entry for BCL11B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the BCL11B gene promoter:
         Sp1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCL11B promoter sequence
   Search Chromatin IP Primers for BCL11B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCL11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32

BCL11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL11B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M099635:  view genomic region     (about GC identifiers)

Start:
99,635,624 bp from pter      End:
99,737,861 bp from pter
Size:
102,238 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0 (See protein sequence)
Recommended Name: B-cell lymphoma/leukemia 11B  
Size: 894 amino acids; 95519 Da
Subunit: Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (By similarity)
Secondary accessions: Q9H162
Alternative splicing: 2 isoforms:  Q9C0K0-1   Q9C0K0-2   (May be due to exon skipping)

Explore the universe of human proteins at neXtProt for BCL11B: NX_Q9C0K0

Explore proteomics data for BCL11B at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO1 (By similarity)1
  • Ubiquitination2 at Lys585, Lys591, Lys597, Lys617, Lys672, Lys686, Lys790, Lys803, Lys806, Lys825,
                                 Lys838, Lys851, Lys875
  • Modification sites at PhosphoSitePlus

  • See BCL11B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269166.1  NP_001269167.1  NP_075049.1  NP_612808.1  

    ENSEMBL proteins: 
     ENSP00000349723   ENSP00000280435   ENSP00000387419  

    BCL11B Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for BCL11B

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    antibodies-online antibodies for BCL11B (46 products) 

    BCL11B Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9C0K0

    ProtoNet protein and cluster: Q9C0K0

    UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0
    Similarity: Contains 6 C2H2-type zinc fingers


    Find genes that share domains with BCL11B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BC11B_HUMAN, Q9C0K0
    Function: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be
    a key regulator of both differentiation and survival during thymocyte development. Repress transcription through
    direct, TFCOUP2-independent binding to a GC-rich response element (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI17245431
    GO:0043565sequence-specific DNA binding ----
         
    Find genes that share ontologies with BCL11B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL11B:
     Increased cell number in G1, s 

         13 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Bcl11b):
     behavior/neurological  cellular  craniofacial  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  no phenotypic analysis 
     skeleton  tumorigenesis  vision/eye 

    Find genes that share phenotypes with BCL11B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BCL11B: Bcl11btm1.2Leid Bcl11btm1Jpk

       genOway: Develop your customized and physiologically relevant rodent model for BCL11B

    miRNA
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    miRTarBase miRNAs that target BCL11B:
    hsa-mir-26b-5p (MIRT028968), hsa-mir-32-5p (MIRT028285), hsa-mir-183-5p (MIRT025027), hsa-mir-128-3p (MIRT021908), hsa-mir-16-5p (MIRT031515), hsa-mir-186-5p (MIRT021103)

    Block miRNA regulation of human, mouse, rat BCL11B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL11B (see all 208):
    hsa-miR-579 hsa-miR-3938 hsa-miR-1224-3p hsa-miR-106a hsa-miR-605 hsa-miR-759 hsa-miR-208b hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat BCL11B

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL11B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BC11B_HUMAN, Q9C0K0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with BCL11B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCL11B About    
    See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with BCL11B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BCL11B
        Lymphocyte Signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including BCL11B: 
              HIV Host Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCL11B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for BCL11B (Q9C0K01, 2, 3 ENSP000003497234) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUV39H1O434631, 2, 3, ENSP000003658774EBI-6597578,EBI-349968 MINT-4299051 MINT-4299030 MINT-4299012 I2D: score=3 STRING: ENSP00000365877
    HDAC3O153792, 3, ENSP000003029674MINT-4298994 I2D: score=2 STRING: ENSP00000302967
    HDAC1Q135471, 2, 3, ENSP000003626494EBI-6597578,EBI-301834 MINT-4298962 MINT-4299084 I2D: score=3 STRING: ENSP00000362649
    HDAC2Q927691, 2, 3, ENSP000003813314EBI-6597578,EBI-301821 MINT-4299069 MINT-4298980 I2D: score=3 STRING: ENSP00000381331
    MBD3O959833, ENSP000001568254I2D: score=2 STRING: ENSP00000156825
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003334keratinocyte development IEA--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0007409axonogenesis ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0009791post-embryonic development ----

    Find genes that share ontologies with BCL11B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCL11B (BC11B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BCL11B gene (4 alternative transcripts): 
    NM_001282237.1  NM_001282238.1  NM_022898.2  NM_138576.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357195 ENST00000345514(uc001yga.3 uc001ygb.3) ENST00000443726

    miRNA
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    Block miRNA regulation of human, mouse, rat BCL11B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCL11B (see all 208):
    hsa-miR-579 hsa-miR-3938 hsa-miR-1224-3p hsa-miR-106a hsa-miR-605 hsa-miR-759 hsa-miR-208b hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat BCL11B

    Selected AceView cDNA sequences (see all 47):

    AA960937 AW016816 NM_022898 AI453101 BG697939 AA480194 AF086271 AA306914 
    BE467735 BX104143 AW612236 BE670095 AA333505 NM_138576 AA777212 AJ404614 
    BP366601 AA918317 AA350215 BI912572 R61554 BQ026852 AA350175 BP429964 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL11B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for BCL11B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCL11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTGCCAT
    BCL11B Expression
    About this image


    BCL11B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Tooth
             Early Ameloblasts Dental Enamel
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 7 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Dental Mesenchymal Cells Branchial Arch 1
    BCL11B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCL11B Protein Expression

    UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0
    Tissue specificity: Highly expressed in brain and in malignant T-cell lines derived from patients with adult
    T-cell leukemia/lymphoma

        Pathway & Disease-focused RT2 Profiler PCR Array including BCL11B: 
              HIV Host Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL11B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BCL11B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcl11b1 , 5 B cell leukemia/lymphoma 11B1, 5 89.08(n)1
    93.63(a)1
      12 (59.10 cM)5
    582081  NM_001079883.11  NP_001073352.11 
     1079104035 
    chicken
    (Gallus gallus)
    Aves BCL11B1 B-cell CLL/lymphoma 11B (zinc finger protein) 76.66(n)
    84.67(a)
      423444  XM_003641410.2  XP_003641458.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCL11B6
    B-cell CLL/lymphoma 11B (zinc finger protein)
    85(a)
    1 ↔ 1
    1(9966877-9968901)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.125102 Transcribed sequences 88.92(n)    BX714097.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003309741 B-cell lymphoma/leukemia 11B-like 70.2(n)
    71.23(a)
      100330974  XM_002667860.3  XP_002667906.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96503   -- 84(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F13H6.13 zinc-finger protein 65(a)   V(6361002-6364336)   --


    ENSEMBL Gene Tree for BCL11B (if available)
    TreeFam Gene Tree for BCL11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCL11B gene
    BCL11A2  ZNF2962  
    Selected SIMAP similar genes for BCL11B using alignment to 2 protein entries:     BC11B_HUMAN (see all proteins) (see all similar genes):
    ATL1    ATL1-alpha    ATL1-delta    ATL1-gamma    BCL11A    ZNF697
    ZNF78L1    ZFS-4    kr-znf3    ZNF    ZFS-5    PLZF
    DKFZp434J0650    HZF16    ZNF72    A-328A3.4    ZFS-2    DKFZp686N0199

    Find genes that share paralogs with BCL11B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCL11B (see all 2042)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355544
    A colorectal cancer sample4--see VAR_0355542 S P mis40--------
    rs2006871401,2
    C--79824915(+) GAAGGC/TGCCGC 4 T A mis11Minor allele frequency- T:0.00EU 333
    rs2008353811,2
    C--79824921(+) GCCGCA/GCTTCT 4 R C mis10--------
    rs1483587261,2
    C--79829445(+) AAAAG-/CTTCTAAA 2 -- int10--------
    rs113850171,2
    C--79837606(+) AAAAA-/AGGCCA 2 -- int1 trp31Minor allele frequency- A:0.50CSA 2
    rs58109281,2
    C,F--79846464(+) GGTTGA/-AAACC 2 -- int13Minor allele frequency- -:0.33NA CSA 6
    rs1482808531,2
    C--79853811(+) CTGAA-/CCCCCC 2 -- int10--------
    rs2009204811,2
    C--79885807(+) AAAAAA/TTAAAA 2 -- int10--------
    rs105285691,2
    C--79893847(+) AAAAA-/AAAAAAA/AAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAA
    AAAAAAAAAAAAAAAA
    /AAAAAAAAAAAAAAAAAAAAAAAAA
    GCAAG
    4 -- int1 cds11NA 2
    rs114391671,2
    C--79908791(+) TTTTT-/TGTGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for BCL11B (99635624 - 99737861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BCL11B (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658925CNV Deletion23128226
    esv2671501CNV Deletion23128226
    esv23236CNV Loss19812545
    nsv832872CNV Loss17160897
    nsv528741CNV Loss19592680
    dgv387n67CNV Gain20364138
    nsv827040CNV Gain20364138
    nsv832871CNV Gain17160897
    nsv827039CNV Gain20364138
    nsv470666CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCL11B
    DNA2.0 Custom Variant and Variant Library Synthesis for BCL11B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606558    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for BCL11B:
    Leukemia

    Find genes that share disorders with BCL11B           About GenesLikeMe

    2 Novoseek inferred disease relationships for BCL11B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 24.7 2 17173069 (1), 12565905 (1)
    tumors 0 1 17369851 (1)


    Export disorders for BCL11B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for BCL11B gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with BCL11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. (PubMed id 11719382)1, 2, 3 Satterwhite E.... Dyer M.J. (Blood 2001)
    2. Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. (PubMed id 12565905)1, 2, 9 Wakabayashi Y.... Kominami R. (Biochem. Biophys. Res. Commun. 2003)
    3. CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. (PubMed id 16950772)1, 3 Topark-Ngarm A....Leid M. (J. Biol. Chem. 2006)
    4. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. (PubMed id 18595722)1, 9 Desplats P.A....Thomas E.A. (Neurobiol. Dis. 2008)
    5. Expression of COUP-TF-interacting protein 2 (CTIP2) in human atopic dermatitis and allergic contact dermatitis skin. (PubMed id 19366371)1, 9 Ganguli-Indra G....Indra A.K. (Exp. Dermatol. 2009)
    6. A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene. (PubMed id 15104287)1, 9 Bezrookove V....Rosenberg C. (Cancer Genet. Cytogenet. 2004)
    7. Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages. (PubMed id 17369851)1, 9 Kamimura K....Kominami R. (Oncogene 2007)
    8. COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. (PubMed id 15849318)1, 9 Marban C....Rohr O. (Nucleic Acids Res. 2005)
    9. Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations. (PubMed id 24441149)1 Abbas S....Valk P.J. (Haematologica 2014)
    10. BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma. (PubMed id 23527175)1 Wiles E.T....Lessnick S.L. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 64919 HGNC: 13222 AceView: BCL11B Ensembl:ENSG00000127152 euGenes: HUgn64919
    ECgene: BCL11B H-InvDB: BCL11B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BCL11B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL11B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BCL11B gene:
    Search GeneIP for patents involving BCL11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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