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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCL11B Gene

protein-coding   GIFtS: 55
GCID: GC14M099635

B-cell CLL/lymphoma 11B (zinc finger protein)


(Previous symbol: ZNF856B)
 Explore 18 diseases affiliated with
BCL11B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BCL11B    

Aliases
for BCL11B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
B-Cell CLL/Lymphoma 11B (Zinc Finger Protein)1 2     ATL1-Delta1
CTIP21 2 3 5     ATL1-Gamma1
CTIP-21 2     ATL1-Alpha Zinc Finger Protein2
ZNF856B1 2     ATL1-Beta Zinc Finger Protein2
HRIT1-Alpha1     ATL1-Delta Zinc Finger Protein2
Radiation-Induced Tumor Suppressor Gene 1 Protein2 3     ATL1-Gamma Zinc Finger Protein2
BCL-11B2 3     B-Cell CLL/Lymphoma 11B/T-Cell Receptor Delta Constant Region Fusion Protein2
RIT12 3     B-Cell Lymphoma/Leukaemia 11B2
COUP-TF-Interacting Protein 22 3     B-Cell Lymphoma/Leukemia 11B2
HRit11     BCL11B/TRDC Fusion2
ATL1-Alpha1     Zinc Finger Protein HRit1 Alpha2
ATL1-Beta1     B-Cell CLL/Lymphoma 11B3

External Ids:    HGNC: 132221   Entrez Gene: 649192   Ensembl: ENSG000001271527   OMIM: 6065585   UniProtKB: Q9C0K03   

Export aliases for BCL11B gene to outside databases

Previous GC identifers: GC14M097147 GC14M093451 GC14M097625 GC14M098705 GC14M079819


Summaries
for BCL11B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BCL11B:
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be
associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively
spliced transcript variants, which encode distinct isoforms, have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0
Function: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a
key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct,
TFCOUP2-independent binding to a GC-rich response element (By similarity)

Gene Wiki entry for BCL11B


Genomic Views
for BCL11B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCL11B gene promoter:
         Sp1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BCL11B promoter sequence
   Search SABiosciences Chromatin IP Primers for BCL11B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32

BCL11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL11B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M099635:  view genomic region     (about GC identifiers)

Start:
 99,635,624 bp from pter      End:
 99,737,861 bp from pter
Size:
 102,238 bases      Orientation:
 minus strand

Proteins
for BCL11B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0 (See protein sequence)
Recommended Name: B-cell lymphoma/leukemia 11B  
Size: 894 amino acids; 95519 Da
Subunit: Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (By similarity)
Subcellular location: Nucleus (Potential)
Secondary accessions: Q9H162
Alternative splicing: 2 isoforms:  Q9C0K0-1   Q9C0K0-2   (May be due to exon skipping)

Explore the universe of human proteins at neXtProt for BCL11B: NX_Q9C0K0

Post-translational modifications:

  • Sumoylated with SUMO1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C0K0

    • BCL11B Protein expression data from MOPED and PaxDb:    About this image 
    BCL11B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_075049.1  NP_612808.1  

    ENSEMBL proteins: 
     ENSP00000349723   ENSP00000280435   ENSP00000387419  

    Human Recombinant Protein Products for BCL11B: 
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    Uscn Proteins for BCL11B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    BCL11B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for BCL11B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BCL11B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9C0K0

    ProtoNet protein and cluster: Q9C0K0

    UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0
    Similarity: Contains 6 C2H2-type zinc fingers


    Function
    for BCL11B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BC11B_HUMAN, Q9C0K0
    Function: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a
    key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct,
    TFCOUP2-independent binding to a GC-rich response element (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    BCL11B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCL11B:
     Increased cell number in G1, s 

         11 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Bcl11b):
     behavior/neurological  cellular  craniofacial  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  no phenotypic analysis  tumorigenesis 
     vision/eye 

    BCL11B for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for BCL11B: Bcl11btm1.2Leid Bcl11btm1Jpk
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BCL11B 

    miRNA
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    8/208 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL11B (see all 208):
    hsa-miR-579 hsa-miR-3938 hsa-miR-1224-3p hsa-miR-106a hsa-miR-605 hsa-miR-759 hsa-miR-208b hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: BCL11B
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL11B


    Pathways & Interactions
    for BCL11B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lymphocyte Signaling
    		Lymphocyte Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BCL11B
        Lymphocyte Signaling



    BCL11B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCL11B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for BCL11B (Q9C0K02, 3 ENSP000003497234) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUV39H1O434632, 3, ENSP000003658774MINT-4299051 MINT-4299030 MINT-4299012 I2D: score=3 STRING: ENSP00000365877
    HDAC3O153792, 3, ENSP000003029674MINT-4298994 I2D: score=2 STRING: ENSP00000302967
    HDAC1Q135472, 3, ENSP000003626494MINT-4298962 MINT-4299084 I2D: score=3 STRING: ENSP00000362649
    HDAC2Q927692, 3, ENSP000003813314MINT-4299069 MINT-4298980 I2D: score=3 STRING: ENSP00000381331
    MBD3O959833, ENSP000001568254I2D: score=2 STRING: ENSP00000156825
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003334keratinocyte development IEA--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0007409axonogenesis ----
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0009791post-embryonic development ----

    BCL11B for ontologies           About GeneDecksing



    Drugs & Compounds
    for BCL11B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCL11B
    Search CenterWatch for drugs/clinical trials and news about BCL11B / BC11B 

    Transcripts
    for BCL11B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BCL11B gene (2 alternative transcripts): 
    NM_022898.1  NM_138576.2  

    Unigene Cluster for BCL11B:

    B-cell CLL/lymphoma 11B (zinc finger protein)
    Hs.709690  [show with all ESTs]
    Unigene Representative Sequence: NM_138576
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357195 ENST00000345514(uc001yga.3 uc001ygb.3) ENST00000443726


    miRNA
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    8/208 QIAGEN miScript miRNA Assays for microRNAs that regulate BCL11B (see all 208):
    hsa-miR-579 hsa-miR-3938 hsa-miR-1224-3p hsa-miR-106a hsa-miR-605 hsa-miR-759 hsa-miR-208b hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCL11B (see all 7)
    OriGene shRNA RFP: BCL11B
    OriGene siRNA: BCL11B
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    Sirion Biotech Custom design and validation of potent shRNA sequences against BCL11B 
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): BCL11B (NM_022898)
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    Primer
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    Additional cDNA sequence: 

    AF086271.1 AJ404614.1 AY752978.1 

    4 DOTS entries:

    DT.120778274  DT.109937  DT.40265161  DT.40310500 

    24/47 AceView cDNA sequences (see all 47):

    AA306914 AA918317 NM_138576 AW016816 AW612236 AF086271 AI453101 AA350215 
    BE467735 AA960937 BP366601 NM_022898 BX104143 AJ404614 AA480194 AA333505 
    AA777212 BG697939 BE670095 BI912572 AA350175 R88646 AW117266 AW957349 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL11B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for BCL11B

    Expression
    for BCL11B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCL11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTCTGCCAT
    BCL11B Expression
    About this image

    BCL11B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BCL11B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCL11B

    SOURCE GeneReport for Unigene cluster: Hs.709690

    UniProtKB/Swiss-Prot: BC11B_HUMAN, Q9C0K0
    Tissue specificity: Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell
    leukemia/lymphoma

        SABiosciences Expression via Pathway-Focused PCR Array including BCL11B: 
              HIV Host Response in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for BCL11B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BCL11B gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BCL11B1 B-cell CLL/lymphoma 11B (zinc finger protein) 77.37(n)
    86.01(a)    		   423444  XM_003641410.1  XP_003641458.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BCL11B6
    --
    		 --
    		 86(a)
    78(a)
    		 1 ↔ many
    1 ↔ many
    		 1(9966877-9968901)
    1(10103099-10103430)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.125102 Transcribed sequences 88.92(n)    BX714097.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003309741 b-cell lymphoma/leukemia 11B-like 67.88(n)
    68.3(a)    		   100330974  XM_002667860.2  XP_002667906.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG96503   -- 84(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea F13H6.13 zinc-finger protein 65(a)   V(6361002-6364336)   --


    ENSEMBL Gene Tree for BCL11B (if available)
    TreeFam Gene Tree for BCL11B (if available) 

    Paralogs
    for BCL11B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCL11B gene
    BCL11A2  ZNF2962  
    18/23 SIMAP similar genes for BCL11B using alignment to 2 protein entries:     BC11B_HUMAN (see all proteins) (see all similar genes):
    BCL11A    ZNF697    ZNF78L1    ZFS-4    kr-znf3    ZNF
    ZFS-5    PLZF    DKFZp434J0650    HZF16    ZNF72    A-328A3.4
    ZFS-2    DKFZp686N0199    PLAGL1    DKFZp686M04222    smap-7    ZNF702P

    BCL11B for paralogs           About GeneDecksing



    Genomic Variants
    for BCL11B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1706 NCBI SNPs in BCL11B are shown (see all 1706)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs577939211,2
    		C--79818788(+) TCTCCC/TTGGGT 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs748430051,2
    		C,F--79821253(+) CAACCC/TTTTTT 2 -- ut311Minor allele frequency- T:0.08NA 120
    rs759338881,2
    		C--79822348(+) TTTTTT/CTTTTA 2 -- ut312Minor allele frequency- C:0.17CSA WA 120
    rs128901361,2
    		C--79824952(+) CCGTAC/ATGCGG 4 /Q /H mis1 ese31Minor allele frequency- A:0.00NA 2
    rs24964781,2
    		--79826320(-) CGGCCC/GCCCAG 2 -- int13Minor allele frequency- G:0.04NA 124
    rs24875081,2
    		--79826341(+) TCTGTA/GGGCGG 2 -- int10--------
    rs740803331,2
    		C--79826410(+) TCCCCC/AAAAGA 2 -- int11Minor allele frequency- A:0.50WA 2
    rs7103041,2
    		C,A--79826415(+) CAAAGA/GAAAGG 2 -- int1 trp32Minor allele frequency- G:0.09CSA WA 120
    rs1122577861,2
    		--79826787(+) CTTTGG/AGAACA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs776049461,2
    		F--79827117(+) AAGGCG/AGGGGC 2 -- int11Minor allele frequency- A:0.04NA 120

    HapMap Linkage Disequilibrium report for BCL11B (99635624 - 99737861 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for BCL11B
         1 CNV: 66707

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    Disorders / Diseases
    for BCL11B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BCL11B for disorders           About GeneDecksing

    OMIM gene information: 606558    OMIM disorders: --

    18 diseases for BCL11B:    About MalaCards
    b-cell lymphomas    allergic contact dermatitis    leukemia    contact dermatitis
    amyotrophic lateral sclerosis    lateral sclerosis    adult t-cell leukemia    atopic dermatitis
    acute lymphoblastic leukemia    dermatitis    lymphoblastic leukemia    leukemia/lymphoma
    squamous cell carcinoma    t-cell leukemia    huntington's disease    immunodeficiency
    carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for BCL11B:
    Leukemia

    2 Novoseek disease relationships for BCL11B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 24.7 2 17173069 (1), 12565905 (1)
    tumors 0 1 17369851 (1)


    Export disorders for BCL11B gene to outside databases

    Publications
    for BCL11B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCL11B gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with BCL11B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. (PubMed id 11719382)1, 2, 3 Satterwhite E.... Dyer M.J. (2001)
    2. Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. (PubMed id 12565905)1, 2, 9 Wakabayashi Y.... Kominami R. (2003)
    3. CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. (PubMed id 16950772)1, 3 Topark-Ngarm A....Leid M. (2006)
    4. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. (PubMed id 18595722)1, 9 Desplats P.A....Thomas E.A. (2008)
    5. Expression of COUP-TF-interacting protein 2 (CTIP2) i n human atopic dermatitis and allergic contact dermatitis skin. (PubMed id 19366371)1, 9 Ganguli-Indra G....Indra A.K. (2009)
    6. A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene. (PubMed id 15104287)1, 9 Bezrookove V....Rosenberg C. (2004)
    7. Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages. (PubMed id 17369851)1, 9 Kamimura K....Kominami R. (2007)
    8. COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells. (PubMed id 15849318)1, 9 Marban C....Rohr O. (2005)
    9. BCL11B tumor suppressor inhibits HDM2 expression in a p53-dependent manner. (PubMed id 22245141)1 Obata M....Mishima Y. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for BCL11B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BCL11B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64919 HGNC: 13222 AceView: BCL11B Ensembl:ENSG00000127152 euGenes: HUgn64919
    ECgene: BCL11B H-InvDB: BCL11B

    Other Databases showing BCL11B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BCL11B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCL11B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCL11B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BCL11B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BCL11B gene:
    Search GeneIP for patents involving BCL11B

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