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Aliases for BCL11B Gene

Aliases for BCL11B Gene

  • B-Cell CLL/Lymphoma 11B 2 3 4
  • B-Cell CLL/Lymphoma 11B (Zinc Finger Protein) 2 3 5
  • Radiation-Induced Tumor Suppressor Gene 1 Protein 3 4
  • COUP-TF-Interacting Protein 2 3 4
  • BCL-11B 3 4
  • CTIP2 3 4
  • HRit1 3 4
  • RIT1 3 4
  • B-Cell CLL/Lymphoma 11B/T-Cell Receptor Delta Constant Region Fusion Protein 3
  • Zinc Finger Protein HRit1 Alpha 3
  • B-Cell Lymphoma/Leukaemia 11B 3
  • BCL11B/TRDC Fusion 3
  • HRIT1-Alpha 3
  • ATL1-Alpha 3
  • ATL1-Delta 3
  • ATL1-Gamma 3
  • ATL1-Beta 3
  • ZNF856B 3
  • CTIP-2 3
  • ATL1 3

External Ids for BCL11B Gene

Previous HGNC Symbols for BCL11B Gene

  • ZNF856B

Previous GeneCards Identifiers for BCL11B Gene

  • GC14M097147
  • GC14M093451
  • GC14M097625
  • GC14M098705
  • GC14M099635
  • GC14M079819

Summaries for BCL11B Gene

Entrez Gene Summary for BCL11B Gene

  • This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for BCL11B Gene

BCL11B (B-Cell CLL/Lymphoma 11B) is a Protein Coding gene. Diseases associated with BCL11B include lymphoma and adult t-cell leukemia. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include nucleic acid binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF296.

UniProtKB/Swiss-Prot for BCL11B Gene

  • Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).

Gene Wiki entry for BCL11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL11B Gene

Genomics for BCL11B Gene

Regulatory Elements for BCL11B Gene

Genomic Location for BCL11B Gene

Chromosome:
14
Start:
99,169,287 bp from pter
End:
99,271,713 bp from pter
Size:
102,427 bases
Orientation:
Minus strand

Genomic View for BCL11B Gene

Genes around BCL11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL11B Gene

Proteins for BCL11B Gene

  • Protein details for BCL11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K0-BC11B_HUMAN
    Recommended name:
    B-cell lymphoma/leukemia 11B
    Protein Accession:
    Q9C0K0
    Secondary Accessions:
    • Q9H162

    Protein attributes for BCL11B Gene

    Size:
    894 amino acids
    Molecular mass:
    95519 Da
    Quaternary structure:
    • Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.

    Alternative splice isoforms for BCL11B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL11B Gene

Proteomics data for BCL11B Gene at MOPED

Post-translational modifications for BCL11B Gene

  • Sumoylated with SUMO1.
  • Ubiquitination at Lys 585, Lys 591, Lys 597, Lys 617, Lys 686, Lys 790, Lys 851, and Lys 875
  • Modification sites at PhosphoSitePlus

Other Protein References for BCL11B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCL11B (Bcl-11B)

No data available for DME Specific Peptides for BCL11B Gene

Domains & Families for BCL11B Gene

Gene Families for BCL11B Gene

Protein Domains for BCL11B Gene

Suggested Antigen Peptide Sequences for BCL11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0K0

UniProtKB/Swiss-Prot:

BC11B_HUMAN :
  • Contains 6 C2H2-type zinc fingers.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with BCL11B: view

Function for BCL11B Gene

Molecular function for BCL11B Gene

UniProtKB/Swiss-Prot Function:
Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).
genes like me logo Genes that share phenotypes with BCL11B: view

Animal Models for BCL11B Gene

MGI Knock Outs for BCL11B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL11B Gene

Localization for BCL11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL11B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL11B Gene COMPARTMENTS Subcellular localization image for BCL11B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BCL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with BCL11B: view

Pathways & Interactions for BCL11B Gene

genes like me logo Genes that share pathways with BCL11B: view

SIGNOR curated interactions for BCL11B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BCL11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003334 keratinocyte development IEA --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0007165 signal transduction IBA --
GO:0007409 axonogenesis IEA --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with BCL11B: view

Drugs & Compounds for BCL11B Gene

No Compound Related Data Available

Transcripts for BCL11B Gene

Unigene Clusters for BCL11B Gene

B-cell CLL/lymphoma 11B (zinc finger protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL11B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for BCL11B Gene

GeneLoc Exon Structure for
BCL11B
ECgene alternative splicing isoforms for
BCL11B

Expression for BCL11B Gene

mRNA expression in normal human tissues for BCL11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL11B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Putamen (basal ganglia) (x5.8), Skin - Sun Exposed (Lower leg) (x5.6), Skin - Not Sun Exposed (Suprapubic) (x5.5), and Brain - Caudate (basal ganglia) (x5.3).

Protein differential expression in normal tissues from HIPED for BCL11B Gene

This gene is overexpressed in CD8 Tcells (19.7), Adipocyte (17.7), CD4 Tcells (8.9), Pancreatic juice (7.9), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCL11B Gene



SOURCE GeneReport for Unigene cluster for BCL11B Gene Hs.709690

mRNA Expression by UniProt/SwissProt for BCL11B Gene

Q9C0K0-BC11B_HUMAN
Tissue specificity: Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
genes like me logo Genes that share expression patterns with BCL11B: view

Protein tissue co-expression partners for BCL11B Gene

Primer Products

In Situ Assay Products

Orthologs for BCL11B Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL11B 36
  • 100 (a)
OneToOne
BCL11B 35
  • 99.74 (n)
  • 99.89 (a)
cow
(Bos Taurus)
Mammalia BCL11B 36
  • 93 (a)
OneToOne
BCL11B 35
  • 94.33 (n)
  • 96.42 (a)
dog
(Canis familiaris)
Mammalia BCL11B 35
  • 96.31 (n)
  • 97.54 (a)
BCL11B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl11b 16
Bcl11b 35
  • 89.08 (n)
  • 93.63 (a)
Bcl11b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL11B 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL11B 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl11b 35
  • 88.8 (n)
  • 92.69 (a)
chicken
(Gallus gallus)
Aves BCL11B 35
  • 76.66 (n)
  • 84.67 (a)
-- 36
  • 85 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia BCL11B 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl11b 35
  • 70.58 (n)
  • 81.64 (a)
Str.12510 35
zebrafish
(Danio rerio)
Actinopterygii BCL11B (2 of 2) 36
  • 60 (a)
OneToMany
bcl11ba 36
  • 76 (a)
OneToMany
LOC100330974 35
  • 70.2 (n)
  • 71.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9650 37
  • 84 (a)
CG9650 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13H6.1 37
  • 65 (a)
F13H6.1 36
  • 16 (a)
OneToMany
Species with no ortholog for BCL11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCL11B Gene

ENSEMBL:
Gene Tree for BCL11B (if available)
TreeFam:
Gene Tree for BCL11B (if available)

Paralogs for BCL11B Gene

Paralogs for BCL11B Gene

genes like me logo Genes that share paralogs with BCL11B: view

Variants for BCL11B Gene

Sequence variations from dbSNP and Humsavar for BCL11B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035554 A colorectal cancer sample
VAR_065741 -
VAR_065742 -
rs807569 -- 99,177,517(+) CAGAC(A/G)GGACC intron-variant
rs807731 -- 99,179,796(+) TCCCC(A/C/T)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL11B Gene

Variant ID Type Subtype PubMed ID
nsv827039 CNV Gain 20364138
nsv827040 CNV Gain 20364138
dgv385n67 CNV Gain 20364138
dgv386n67 CNV Gain 20364138
esv2671501 CNV Deletion 23128226
dgv387n67 CNV Gain 20364138
esv23236 CNV Loss 19812545
esv275067 CNV Gain+Loss 21479260
nsv470666 CNV Gain 18288195
nsv832871 CNV Gain 17160897
nsv832872 CNV Loss 17160897
nsv528741 CNV Loss 19592680
esv2658925 CNV Deletion 23128226
nsv827049 CNV Gain 20364138

Variation tolerance for BCL11B Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL11B Gene

HapMap Linkage Disequilibrium report
BCL11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL11B Gene

Disorders for BCL11B Gene

MalaCards: The human disease database

(4) MalaCards diseases for BCL11B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
adult t-cell leukemia
  • adult t-cell leukemia/lymphoma
t-cell leukemia
  • leukemia t-cell
hematologic cancer
  • blood cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BCL11B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCL11B
genes like me logo Genes that share disorders with BCL11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL11B Gene

Publications for BCL11B Gene

  1. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. (PMID: 11719382) Satterwhite E. … Dyer M.J. (Blood 2001) 2 3 4 67
  2. Expression of COUP-TF-interacting protein 2 (CTIP2) in human atopic dermatitis and allergic contact dermatitis skin. (PMID: 19366371) Ganguli-Indra G. … Indra A.K. (Exp. Dermatol. 2009) 3 23
  3. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. (PMID: 18595722) Desplats P.A. … Thomas E.A. (Neurobiol. Dis. 2008) 3 23
  4. Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages. (PMID: 17369851) Kamimura K. … Kominami R. (Oncogene 2007) 3 23
  5. CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. (PMID: 16950772) Topark-Ngarm A. … Leid M. (J. Biol. Chem. 2006) 2 3

Products for BCL11B Gene

Sources for BCL11B Gene

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