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Aliases for BCL10 Gene

Aliases for BCL10 Gene

  • B-Cell CLL/Lymphoma 10 2 3 4 5
  • CED-3/ICH-1 Prodomain Homologous E10-Like Regulator 3 4
  • Mammalian CARD-Containing Adapter Molecule E10 3 4
  • CARD-Containing Molecule Enhancing NF-Kappa-B 3 4
  • Caspase-Recruiting Domain-Containing Protein 2 3
  • CARD-Containing Apoptotic Signaling Protein 2 3
  • CARD Containing Molecule Enhancing NF-KB 2 3
  • CARD-Containing Proapoptotic Protein 2 3
  • CARD-Like Apoptotic Protein 2 4
  • Cellular Homolog Of VCARMEN 3 4
  • Cellular-E10 3 4
  • CCARMEN 3 4
  • CIPER 3 4
  • C-E10 3 4
  • HCLAP 3 4
  • CLAP 3 4
  • ME10 3 4
  • CARMEN 3
  • Bcl-10 4
  • IMD37 3

External Ids for BCL10 Gene

Previous GeneCards Identifiers for BCL10 Gene

  • GC01M086131
  • GC01M084873
  • GC01M085020
  • GC01M085154
  • GC01M085443
  • GC01M085731
  • GC01M083842

Summaries for BCL10 Gene

Entrez Gene Summary for BCL10 Gene

  • This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for BCL10 Gene

BCL10 (B-Cell CLL/Lymphoma 10) is a Protein Coding gene. Diseases associated with BCL10 include Immunodeficiency 37 and Lymphoma, Malt, Somatic. Among its related pathways are TCR signaling (REACTOME) and NF-kappaB Signaling. GO annotations related to this gene include protein kinase binding and transcription factor binding.

UniProtKB/Swiss-Prot for BCL10 Gene

  • Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

Gene Wiki entry for BCL10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL10 Gene

Genomics for BCL10 Gene

Regulatory Elements for BCL10 Gene

Enhancers for BCL10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BCL10 on UCSC Golden Path with GeneCards custom track

Promoters for BCL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BCL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCL10 Gene

85,265,776 bp from pter
85,277,090 bp from pter
11,315 bases
Minus strand

Genomic View for BCL10 Gene

Genes around BCL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL10 Gene

Proteins for BCL10 Gene

  • Protein details for BCL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B-cell lymphoma/leukemia 10
    Protein Accession:
    Secondary Accessions:
    • Q5VUF1

    Protein attributes for BCL10 Gene

    233 amino acids
    Molecular mass:
    26252 Da
    Quaternary structure:
    • Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).

    Three dimensional structures from OCA and Proteopedia for BCL10 Gene

neXtProt entry for BCL10 Gene

Proteomics data for BCL10 Gene at MOPED

Post-translational modifications for BCL10 Gene

  • Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL10 Gene

Domains & Families for BCL10 Gene

Gene Families for BCL10 Gene

Protein Domains for BCL10 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CARD domain.
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with BCL10: view

Function for BCL10 Gene

Molecular function for BCL10 Gene

GENATLAS Biochemistry:
CARD containing apoptotic signaling protein,B cell CLL/lymphoma 10,cellular homolog of equine herpesvirus-2 E10 gene,inducing NFKB activation
UniProtKB/Swiss-Prot Function:
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

Gene Ontology (GO) - Molecular Function for BCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008022 protein C-terminus binding IPI 11053425
GO:0019900 kinase binding IPI 16831874
GO:0043422 protein kinase B binding IPI 16280327
genes like me logo Genes that share ontologies with BCL10: view
genes like me logo Genes that share phenotypes with BCL10: view

Human Phenotype Ontology for BCL10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for BCL10 Gene

MGI Knock Outs for BCL10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BCL10 Gene

Localization for BCL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL10 Gene

Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

Subcellular locations from

Jensen Localization Image for BCL10 Gene COMPARTMENTS Subcellular localization image for BCL10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
extracellular 1

Gene Ontology (GO) - Cellular Components for BCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IDA 16127295
genes like me logo Genes that share ontologies with BCL10: view

Pathways & Interactions for BCL10 Gene

genes like me logo Genes that share pathways with BCL10: view

SIGNOR curated interactions for BCL10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA,ISS 11163238
GO:0002224 toll-like receptor signaling pathway IC 16831874
GO:0002250 adaptive immune response TAS 16831874
GO:0006968 cellular defense response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with BCL10: view

Drugs & Compounds for BCL10 Gene

(2) Drugs for BCL10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for BCL10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BCL10: view

Transcripts for BCL10 Gene

Unigene Clusters for BCL10 Gene

B-cell CLL/lymphoma 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL10 Gene

No ASD Table

Relevant External Links for BCL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCL10 Gene

mRNA expression in normal human tissues for BCL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCL10 Gene

This gene is overexpressed in Cervix (15.3), Lymph node (8.6), and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BCL10 Gene

SOURCE GeneReport for Unigene cluster for BCL10 Gene Hs.193516

mRNA Expression by UniProt/SwissProt for BCL10 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with BCL10: view

Protein tissue co-expression partners for BCL10 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for BCL10 Gene

Orthologs for BCL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BCL10 35
  • 92.61 (n)
  • 96.52 (a)
BCL10 36
  • 96 (a)
(Canis familiaris)
Mammalia BCL10 35
  • 91.99 (n)
  • 94.42 (a)
BCL10 36
  • 94 (a)
(Mus musculus)
Mammalia Bcl10 35
  • 83.83 (n)
  • 90.99 (a)
Bcl10 16
Bcl10 36
  • 91 (a)
(Pan troglodytes)
Mammalia BCL10 35
  • 99.71 (n)
  • 100 (a)
BCL10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bcl10 35
  • 82.55 (n)
  • 91.42 (a)
(Monodelphis domestica)
Mammalia BCL10 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia BCL10 36
  • 73 (a)
(Gallus gallus)
Aves BCL10 35
  • 69.48 (n)
  • 66.67 (a)
BCL10 36
  • 61 (a)
(Anolis carolinensis)
Reptilia BCL10 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl10 35
  • 58.3 (n)
  • 52.02 (a)
(Danio rerio)
Actinopterygii LOC100334750 35
  • 55.15 (n)
  • 51.61 (a)
bcl10 36
  • 47 (a)
Species with no ortholog for BCL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL10 Gene

Gene Tree for BCL10 (if available)
Gene Tree for BCL10 (if available)

Paralogs for BCL10 Gene

No data available for Paralogs for BCL10 Gene

Variants for BCL10 Gene

Sequence variations from dbSNP and Humsavar for BCL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_013208 -
VAR_013209 -
VAR_013210 -
VAR_013211 -
VAR_013212 -

Structural Variations from Database of Genomic Variants (DGV) for BCL10 Gene

Variant ID Type Subtype PubMed ID
esv34165 CNV Loss 18971310
nsv830459 CNV Loss 17160897

Variation tolerance for BCL10 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.43; 71.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCL10 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL10 Gene

Disorders for BCL10 Gene

MalaCards: The human disease database

(25) MalaCards diseases for BCL10 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 37
  • imd37
lymphoma, malt, somatic
  • malt lymphoma
testicular germ cell tumor
  • male germ cell tumor, somatic
mesothelioma, somatic
  • malignant mesothelioma
pleural mesothelioma
  • malignant pleural mesothelioma
- elite association - COSMIC cancer census association via MalaCards
Search BCL10 in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency 37 (IMD37) [MIM:616098]: A form of primary combined immunodeficiency, a group of disorders characterized by severe recurrent infections, with normal numbers or an absence of T and B lymphocytes, and impaired cellular and humoral immunity. IMD37 is characterized by hypogammaglobulinemia without lymphopenia, but with profoundly reduced memory B cells and memory T cells, and increased numbers of circulating naive lymphocytes. Inheritance is autosomal recessive. {ECO:0000269 PubMed:25365219}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

Genatlas disease for BCL10 Gene

B cell/lymphoma 10,of mucosa associated lymphoid tissues (MALT lymphomas),affecting predominantly the gastric mucosa,low grade evolving to high grade form with translocation t(1;14)(p22;q32)

Relevant External Links for BCL10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BCL10: view

Publications for BCL10 Gene

  1. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. (PMID: 9989495) Willis T.G. … Dyer M.J.S. (Cell 1999) 2 3 4 23 67
  2. Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma. (PMID: 19279678) Noels H. … Baens M. (PLoS ONE 2009) 3 23
  3. BCL10 single nucleotide polymorphism and its association with CSF dissemination of primary intracranial germ cell tumors. (PMID: 19690445) Hayashi Y. … Hamada J. (Pediatr Neurosurg 2009) 3 23
  4. STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells. (PMID: 19709433) Nagy Z.S. … Kirken R.A. (Mol. Cancer 2009) 3 23
  5. The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. (PMID: 18625728) McCully R.R. … Pomerantz J.L. (Mol. Cell. Biol. 2008) 3 23

Products for BCL10 Gene

Sources for BCL10 Gene