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CCND1 Gene

protein-coding GIFtS: 72

GC11P069165

cyclin D1
(Previous name: cyclin D1 (PRAD1: parathyroid adenomatosis 1) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: BCL1, D11S287E, PRAD1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCL1 ^², ³, ⁵
D11S287E ^²
PRAD1 ^², ³, ⁵
U21B31 ^¹, ²

Descriptions
B-cell CLL/lymphoma 1 ^²
BCL-1 oncogene ^³
G1/S-specific cyclin D1 ^²
PRAD1 oncogene ^³
cyclin D1 ^²
cyclin D1 (PRAD1: parathyroid adenomatosis 1) ^¹

External Ids
HGNC: 1582¹
Entrez Gene: 595²
UniProtKB: P24385³
Ensembl: ENSG00000110092⁷

Search outside databases for aliases for CCND1 gene

Previous GC identifers: GC11P071950 GC11P071141 GC11P069704 GC11P069228

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CCND1:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are

characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins

function as regulators of CDK kinases. Different cyclins exhibit distinct expression and

degradation patterns which contribute to the temporal coordination of each mitotic event. This

cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity

is required for cell cycle G1/S transition. This protein has been shown to interact with tumor

suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations,

amplification and overexpression of this gene, which alters cell cycle progression, are observed

frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385

Function: Essential for the control of the cell cycle at the G1/S (start) transition

Gene Wiki entry for CCND1 (Cyclin_D1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CCND1 gene

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13

CCND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P069165: (about GC identifiers)

Start:	69,165,054 bp from pter
End:	69,178,423 bp from pter
Size:	13,370 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_078088.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385 (See protein sequence)

Recommended Name: G1/S-specific cyclin-D1

Size: 295 amino acids; 33729 Da

Subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase

holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex

PDB structures from and Proteopedia :

2W96 (3D)

2W99 (3D)

2W9F (3D)

2W9Z (3D)

Secondary accessions: Q6LEF0

Post-translational modifications:

Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following

DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF

(SKP1-cullin-F-box) protein ligase complex¹

Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex

containing FBXO31. Ubiquitination leads to its degradation and G1 arrest¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_444284.1

ENSEMBL proteins:

ENSP00000227507

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CCND1
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CCND1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CDK6 + CCND1, Cdk4 + Cyclin D1, Cyclin D1)
	Human Recombinant Proteins from Abnova (CCND1)

OriGene Purified Recombinant Human Protein: CCND1

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA	--
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IDA	11256614
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	EXP	9190208 16782892

About this table

Antibodies for CCND1:

	Invitrogen Antibodies for CCND1
	Millipore Mono- and Polyclonal Antibodies for the study of CCND1
	Sigma-Aldrich Antibody Arrays and Antibodies for CCND1
	R&D Systems Antibodies for CCND1 (Cyclin D1)
	Cell Signaling Technology (CST) Antibodies for CCND1 (Cyclin D1)
	Antibodies from Abcam (CDK6 + CCND1, Cdk4 + Cyclin D1, Cyclin D1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CCND1)
	Novus Biologicals Antibodies for CCND1

Assays for CCND1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of CCND1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P24385

ProtoNet protein and cluster: P24385

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385

Similarity: Belongs to the cyclin family. Cyclin D subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCND1)
		Millipore RNAi Products for the Analysis of CCND1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CCND1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053056

Applied Biosystems Silencer® siRNAs for CCND1

Sigma-Aldrich siRNA and siRNA Panels for CCND1

Sigma-Aldrich shRNA Panels and shRNA for CCND1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CCND1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_053056
Myc/DDK tagged cDNA clone in CMV expression vector: NM_053056
untagged cDNA clone in CMV expression vector: NM_053056

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_053056

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385

Function: Essential for the control of the cell cycle at the G1/S (start) transition

Genatlas biochemistry entry for CCND1:

cyclin D1,regulator of progression through G1 phase during the cell cycle 1,involved with CDK4 in

phosphorylating retinoblastoma protein,STAT5A-regulated transcription,target of activating factor

2 (ATF2) in chondrocytes,overexpressed in parathyroid adenoma,breast (stimulatory effect of

estradiol and prolactin),carcinoma,in anaplastic astrocytoma squamous cell carcinoma mantle cell

lymphoma (same as BCL1,D11S287E)

15/19 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ccnd1) (see all 19 ):

	behavior/neurological	cellular	craniofacial	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system	normal	reproductive system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	15232106 17254966 17274640 17334399
GO:0016538	cyclin-dependent protein kinase regulator activity	IEA	--
GO:0019901	protein kinase binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/22 Sigma-Aldrich "Your Favorite Gene" Pathways for CCND1 (Your Favorite Gene powered by Ingenuity) (see all 22 )

Aryl Hydrocarbon Receptor Signaling
Endometrial Cancer Signaling
Melanoma Signaling
Small Cell Lung Cancer Signaling
Molecular Mechanisms of Cancer

GeneDecks CCND1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CCND1

5/372 Interacting proteins for CCND1 (P24385^{1, 2} ENSP00000227507³) via UniProtKB, MINT, and/or STRING (see all 372 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN1B	P46527¹, ENSP00000228872³	EBI-375001, EBI-519280 STRING (score=.999)
BRCA1	P38398¹, ENSP00000350283³	EBI-375001, EBI-349905 STRING (score=.994)
CDK4	P11802¹^,², ENSP00000257904³	EBI-375001, EBI-295644 MINT-50433 EBI-375001, EBI-295644 MINT-50433 STRING (score=.999)
CDK6	Q00534¹^,², ENSP00000265734³	EBI-375001, EBI-295663 MINT-50434 EBI-375001, EBI-295663 MINT-50434 STRING (score=.999)
MCM10	Q7L590¹^,², ENSP00000354945³	EBI-375001, EBI-374912 MINT-50435 EBI-375001, EBI-374912 MINT-50435 STRING (score=.998)

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5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	NAS	--
GO:0000320	re-entry into mitotic cell cycle	IEA	--
GO:0001934	positive regulation of protein amino acid phosphorylation	IDA	8114739
GO:0010039	response to iron ion	IEA	--
GO:0030968	endoplasmic reticulum unfolded protein response	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CCND1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CCND1
10/54 Novoseek chemical compound relationships for CCND1 gene (see all 54 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	57.02	35	9891068 (4), 16123159 (2), 10927622 (1), 12768030 (1) (see all 27)
pd 98,059	53.44	17	11341512 (1), 17478933 (1), 10683762 (1), 10385595 (1) (see all 16)
glycogen	51.19	47	12522140 (2), 17519353 (2), 19064714 (2), 11522658 (1) (see all 37)
bromodeoxyuridine	51.07	16	8988060 (2), 11260083 (1), 10913198 (1), 19032445 (1) (see all 13)
su9516	50.77	2	12234612 (2)
progesterone	50.54	93	16123159 (3), 15226262 (2), 16844559 (2), 14559845 (2) (see all 74)
sb-216763	49.42	5	18474214 (1), 15753396 (1), 16024653 (1), 16984735 (1) (see all 5)
tyrosine	47.98	29	8479754 (2), 10688905 (2), 15569985 (1), 16323429 (1) (see all 25)
thymidine	44.72	17	18790789 (2), 11322789 (1), 11564890 (1), 15665290 (1) (see all 16)
inostamycin	40.05	6	9600126 (4), 15672866 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCND1)
		Millipore RNAi Products for the Analysis of CCND1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CCND1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053056

Sigma-Aldrich siRNA and siRNA Panels for CCND1

Sigma-Aldrich shRNA Panels and shRNA for CCND1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_053056

REFSEQ mRNAs for CCND1 gene:

NM_053056.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_053056

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_053056
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_053056
                                 untagged cDNA clone in CMV expression vector: NM_053056

Additional cDNA sequence:

AB075505.1 AK299044.1 AK313136.1 BC000076.2 BC001501.2 BC014078.2 BC023620.2 BC025302.1

BT019844.1 BT019845.1 CR536538.1 CR542099.1 CR602163.1 CR605397.1 CR624763.1 M64349.1

M73554.1 M74092.1 S71637.1 X59798.1

24/25 DOTS entries (see all 25 ):

DT.455928 DT.95276487 DT.97805708 DT.95276453 DT.100856781 DT.100667121 DT.120734257 DT.100058492

DT.120734332 DT.120734266 DT.120734335 DT.97846762 DT.40213212 DT.75132881 DT.86841142 DT.100042942

DT.120734264 DT.120734273 DT.120734358 DT.86839165 DT.95276478 DT.95276452 DT.95276461 DT.97824661

24/690 AceView cDNA sequences (see all 690 ):

BE645864 BQ000354 BE873437 CR536538 BE733859 NM_053056 BM744723 CF127185

R81200 BF765167 BQ688166 BM471396 BQ025942 BC023620 BU845062 CR605397

BC001501 BM562600 CF129264 CR542099 AU141798 BQ010133 BU509374 AU107928

highest scoring ESTs for CCND1:

M64349 M73554 X59798 AA025369 AA029402 AA063257 AA064623 AA064665 AA064705 AA064713

Unigene Cluster for CCND1:

Cyclin D1

Hs.523852 [show with all ESTs]

Unigene Representative Sequence: NM_053056

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCND1

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6
SP1:											-		-				-
SP2:
SP3:																					-
SP4:							-		-		-		-
SP5:																	-

About this scheme

ECgene alternative splicing isoforms for CCND1

1 Ensembl transcript including schematic representation:

ENST00000227507

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CCND1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CCND1

¹ / ² / ³

7 probe-sets matching CCND1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2017_s_at²^{, 3}	U95-A	1	1.00	1.00	0.83	0.65	M64349	1.00	1.00	1.00	1
2020_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.10	M73554	1.00	1.00	1.00	1
38418_at²^{, 3}	U95-A	1	0.94	1.00	0.97	1.26	X59798	1.00	1.00	1.00	1
208712_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M73554	1.00	1.00	1.00	1
208711_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000076	0.80	1.00	0.91	1
208712_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208711_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CCND1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAGTCTAGA

SOURCE GeneReport for Unigene cluster: Hs.523852
Expression variation in blood from EXPOLDB for CCND1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCND1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCND1¹	--	cyclin D1	91.84(n) 94.56(a)	449028 NM_001005757.1 NP_001005757.1
cow (Bos taurus)	CCND1¹	--	cyclin D1	92.63(n) 93.88(a)	524530 NM_001046273.1 NP_001039738.1
rat (Rattus norvegicus)	Ccnd1¹	--	cyclin D1	88.93(n) 92.88(a)	58919 NM_171992.2 NP_741989.2
mouse (Mus musculus)	Ccnd1^{1, 5}	7 (72.30 cM)⁵	cyclin D1^{1, 5}	90.06(n)¹ 93.9(a)¹	12443¹ NM_007631.2¹ NP_031657.1¹ AF212040⁵ AF384675⁵ (see all 23)
chicken (Gallus gallus)	CCND1¹	--	cyclin D1	78.54(n) 86.99(a)	396341 NM_205381.1 NP_990712.1

About this table Species with no ortholog for CCND1

ENSEMBL Gene Tree for CCND1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CCND1 gene

CCND3² CCND2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/154 NCBI SNPs in CCND1 are shown (see all 154 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 79)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7177^1,2	A,C,F,H	69175296(+)	`GCTCCA/CCTGAC`	1	--	ut3¹ ese³		6	NS MN EU EA WA	770
	rs678653^1,2	A,C,F,H	69175918(+)	`GCGTGG/CCCGTG`	1	--	ut3¹ ese³		18	NS MN CSAM EA EU WA	2020
	rs3212897^1,2	C,F,H	69176347(+)	`CTTGTT/GTGCAA`	1	--	ut3¹ ese³		5	NS EA WA	630
	rs7178^1,2	C,F,H	69178211(+)	`TGTGTA/GTCGAG`	1	--	ut3¹ ese³		15	NS MN EU EA WA NA	1776
--	rs3212907^1,2	A,C,F	69177957(+)	`GGTCAC/TCTAGC`	1	--	ut3¹ ese³		8	NS	1012
	rs3212861^1,2	C,F,H	69164632(+)	`TCTTGG/AAAATG`	1	--	ng5¹		4	NS EU EA	602
	rs3212860^1,2	C,F,H	69164288(+)	`AAGGCA/TGCCCG`	1	--	ng5¹		12	NS EU EA WA	1430
	rs3212898^1,2	C,F,H	69176518(+)	`TGGTGC/TCAACT`	1	--	ut3¹		6	NS EU EA WA	750
	rs954619^1,2	C,F,H	69163915(+)	`AACACC/TTATCG`	1	--	ng5¹ tfbs³		4	NS MN EU	608
	rs11263523^1,2	C,H	69167840(+)	`CCGCAC/GGATTT`	1	H/Q	mis¹ ese³		8	EU EA WA	832

About this table

HapMap Linkage Disequilibrium images for CCND1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 168461 disorders: 114500 193300

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385

A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy,

particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene

regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell

cycle

A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas

[MIM:168461]. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer

A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500].

Translocation t(11;14)(q13;q32) with the IgH locus

10/96 Novoseek disease relationships for CCND1 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	90.27	362	11286838 (5), 9497916 (5), 15509364 (4), 10201002 (3) (see all 99)
tumors	82.67	1468	10205781 (7), 17631760 (6), 10329035 (6), 15545188 (5) (see all 99)
breast cancer	77.58	599	17653856 (6), 17626745 (5), 17278098 (5), 12376514 (5) (see all 99)
cancer	76.83	429	18498074 (6), 12899785 (5), 16732330 (4), 16863592 (4) (see all 99)
lymphoma	76.53	373	7540362 (5), 12591969 (5), 11159766 (4), 11291051 (3) (see all 99)
carcinoma squamous cell	76.52	261	10766394 (6), 17067457 (5), 9816282 (4), 11870667 (3) (see all 99)
lymphoma mantle-cell	76.04	17	9846986 (2), 8204893 (2), 7772515 (1), 9010577 (1) (see all 12)
lymphoma small lymphocytic	72.54	12	9556424 (2), 11697516 (1), 9652725 (1), 10319380 (1) (see all 9)
carcinoma	70.06	303	17374259 (5), 15354413 (4), 18047954 (4), 17631760 (4) (see all 99)
lymphoma b-cell	69.53	47	18343791 (3), 7540362 (2), 14654791 (2), 7918073 (2) (see all 36)

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Human Gene Mutation Database: CCND1
Genetic Association Database: CCND1
Human Genome Epidemiology Navigator: CCND1 (124 documents)
Tumor Gene Database: CCND1
Breast Cancer Gene Database: CCND1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2962 PubMed articles for CCND1 gene (see all 2962 ):

A novel cyclin encoded by a bcl1-linked candidate oncogene. (PubMed id 1826542)^{1, 2, 3, 4} Motokura T.... Arnold A. (1991)
Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PubMed id 1833066)^{2, 3, 4} Lew D.J....Reed S.I. (1991)
Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. (PubMed id 11698342)^{1, 3, 6} Simpson D.J....Farrell W.E. (2001)
Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. (PubMed id 11696452)^{1, 3, 6} Holley S.L....Hoban P.R. (2001)
Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. (PubMed id 11896626)^{1, 3, 6} Porter T.R....Maher E.R. (2002)
CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin- dependent kinases that associate with cyclin D1. (PubMed id 8302605)^{1, 3, 4} Bates S....Peters G. (1994)
Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma. (PubMed id 15971196)^{1, 3, 6} Casson A.G....Guernsey D.L. (2005)
Association of cyclin D1 genotype with breast cancer risk and survival. (PubMed id 15668481)^{1, 3, 6} Shu X.O....Zheng W. (2005)
Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer. (PubMed id 15245939)^{1, 3, 6} Ito M....Ogawa O. (2004)
Association of cyclin D1 (G870A) polymorphism with susceptibility to esophageal and gastric cardiac carcinoma in a northern Chinese population. (PubMed id 12673692)^{1, 3, 6} Zhang J....Wang S. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 595	HGNC: 1582	AceView: CCND1	Ensembl:ENSG00000110092	euGenes: HUgn595
ECgene: CCND1	H-InvDB: CCND1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CCND1	Genetics and Cytogenetics in Oncology and Haematology
Mammary Transgene Database entry for CCND1	More genetic and clinical information
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccnd1/

Licensable Technologies for CCND1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CCND1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CCND1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCND1		Antibodies for CCND1
	Explore super-pooled esiRNAs		Proteins for CCND1
	Lentivirus-delivered shRNAs for CCND1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CCND1)
	Antibodies (CCND1)
	Chimera RNAi (CCND1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CCND1 (Cyclin D1)

	Recombinant Proteins (CDK6 + CCND1, Cdk4 + Cyclin D1, Cyclin D1)
	Antibodies (CDK6 + CCND1, Cdk4 + Cyclin D1, Cyclin D1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CCND1

	Drugs for CCND1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CCND1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CCND1 Gene at Home site.
Version 2.41.1
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CCND1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for CCND1

Summaries
for CCND1

Genomic Location
for CCND1

Proteins
for CCND1

Protein Domains/
Families
for CCND1

Gene Function
for CCND1

Pathways & Interactions
for CCND1

Drugs & Compounds
for CCND1

Transcripts
for CCND1

Expression
for CCND1

Orthologs
for CCND1

Paralogs
for CCND1

SNPs/Variants
for CCND1

Disorders & Mutations
for CCND1

Medical News
for CCND1

Publications
for CCND1

Search for CCND1

Genome Databases showing CCND1

Other Databases showing CCND1

Specialized Databases showing CCND1

Licensable Technologies
for CCND1

Services
for CCND1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CCND1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor CCND1

Summariesfor CCND1

Genomic Locationfor CCND1

Proteinsfor CCND1

Protein Domains/Familiesfor CCND1

Gene Functionfor CCND1

Pathways & Interactionsfor CCND1

Drugs & Compoundsfor CCND1

Transcriptsfor CCND1

Expression for CCND1

Orthologsfor CCND1

Paralogsfor CCND1

SNPs/Variantsfor CCND1

Disorders & Mutationsfor CCND1

Medical Newsfor CCND1

Publicationsfor CCND1

Search for CCND1

Genome Databases showing CCND1

Other Databases showing CCND1

Specialized Databases showing CCND1

Licensable Technologiesfor CCND1

Servicesfor CCND1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CCND1

Summaries
for CCND1

Genomic Location
for CCND1

Proteins
for CCND1

Protein Domains/
Families
for CCND1

Gene Function
for CCND1

Pathways & Interactions
for CCND1

Drugs & Compounds
for CCND1

Transcripts
for CCND1

Expression
for CCND1

Orthologs
for CCND1

Paralogs
for CCND1

SNPs/Variants
for CCND1

Disorders & Mutations
for CCND1

Medical News
for CCND1

Publications
for CCND1

Licensable Technologies
for CCND1

Services
for CCND1