BCKDK Gene
protein-coding GIFtS: 59
GCID: GC16P031117
|
|
branched chain ketoacid dehydrogenase kinase
| |
Aliases
for BCKDK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Branched Chain Ketoacid Dehydrogenase Kinase1 2 | | BDK2 | | BCKD-Kinase1 | | [3-Methyl-2-Oxobutanoate Dehydrogenase [Lipoamide]] Kinase, Mitochondrial2 | | BCKDHKIN2 3 | | Branched Chain Alpha-Ketoacid Dehydrogenase Kinase2 | | EC 2.7.11.43 8 | | Branched-Chain Alpha-Ketoacid Dehydrogenase Kinase3 | | BCKDKD2 | | EC 2.7.118 |
Export aliases for BCKDK gene to outside databasesPrevious GC identifers: GC16P030201 GC16P031616 GC16P031116 GC16P031155 GC16P031027 GC16P031024 GC16P028680 |
Summaries
for BCKDK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BCKDK:
The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, andisoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylatesand inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. (providedby RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: BCKD_HUMAN, O14874Function: Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex,the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate theactivity state of the BCKD complex (By similarity)
Gene Wiki entry for BCKDK
|
Genomic Views
for BCKDK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BCKDK gene promoter:
SRF C/EBPbeta AML1a Pax-5 Tal-1 SRF (504 AA) E47 COMP1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BCKDK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCKDK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2BCKDK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P031117: view genomic region
(about GC identifiers)
Start:
|
31,117,428 bp from pter |
End:
|
31,124,112 bp from pter |
Size:
|
6,685 bases |
Orientation:
|
plus strand |
|
Proteins
for BCKDK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BCKD_HUMAN, O14874 (See
protein sequence)Recommended Name: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor Size: 412 amino acids; 46360 Da
Subunit: Monomer (By similarity)
Subcellular location: Mitochondrion matrix
Secondary accessions: Q6FGL4 Q96IN5Explore the universe of human proteins at neXtProt for BCKDK: NX_O14874
Post-translational modifications:
Autophosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14874
2 DME Specific Peptides for BCKDK (O14874)
BCKDK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001116429.1 NP_001258855.1 NP_005872.2
ENSEMBL proteins: ENSP00000378405 ENSP00000456479 ENSP00000378404 ENSP00000287507 ENSP00000219794 ENSP00000455866 ENSP00000454947 ENSP00000457226 ENSP00000457821
Human Recombinant Protein Products for BCKDK:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
BCKDK for ontologies About GeneDecksing
BCKDK Antibody Products:
Assay Products for BCKDK: |
Protein
Domains /
Families
for BCKDK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BCKDK for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14874ProtoNet protein and cluster: O14874 2 Blocks protein families: IPB003594 ATP-binding region IPB004358 Bacterial sensor protein C-terminal signature
UniProtKB/Swiss-Prot: BCKD_HUMAN, O14874Similarity: Belongs to the PDK/BCKDK protein kinase familySimilarity: Contains 1 histidine kinase domain |
Function
for BCKDK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: BCKD_HUMAN, O14874Function: Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex,the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate theactivity state of the BCKD complex (By similarity)Catalytic activity: ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP +[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate Enzyme Numbers (IUBMB): EC 2.7.11.41 2 EC 2.7.112
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
BCKDK for ontologies About GeneDecksing
Phenotypes:
7 GenomeRNAi human phenotypes for BCKDK:
11 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bckdk):
BCKDK for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCKDK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCKDK (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BCKDK (NM_005881) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCKDK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCKDK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCKDK |
|
Pathways & Interactions
for BCKDK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BCKDK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/55 Interacting proteins for BCKDK (O148741, 2, 3 ENSP000002197944) via UniProtKB, MINT, STRING, and/or I2D (see all 55)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
BCKDK for ontologies About GeneDecksing
|
Drugs & Compounds
for BCKDK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BCKDK for compounds About GeneDecksing
 Browse Tocris compounds for BCKDK
3 HMDB Compounds for BCKDK About this table
2 DrugBank Compounds for BCKDK About this table
1 Novoseek chemical compound relationship for BCKDK gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pyruvate |
42.6 |
2 |
1496922 (1), 11915939 (1) |
Search CenterWatch for drugs/clinical trials and news about BCKDK / BCKD
|
Transcripts
for BCKDK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BCKDK gene (3 alternative transcripts): NM_001122957.2 NM_001271926.1 NM_005881.3 Unigene Cluster for BCKDK: Branched chain ketoacid dehydrogenase kinase Hs.513520 [show with all ESTs]Unigene Representative Sequence: NM_00112295710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394951 ENST00000567530 ENST00000394950 ENST00000287507 ENST00000219794(uc002eaw.4 uc002eav.4 uc010cai.3)
ENST00000566568 ENST00000561755 ENST00000567676 ENST00000484226 ENST00000567682
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCKDK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCKDK (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BCKDK (NM_005881) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCKDK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCKDK |
Additional cDNA sequence: AF026548.1 AK130145.1 AK294691.1 BC007363.2 BC009872.2 CR542093.1 23 DOTS entries: DT.95368531 DT.100881645 DT.100881627 DT.100881636 DT.120712259 DT.100881653 DT.100881638 DT.116459 DT.120712285 DT.100881648 DT.100881654 DT.100881626 DT.120712250 DT.95368536 DT.100881632 DT.100881649 DT.100833467 DT.120712241 DT.86821246 DT.95368522 DT.95378618 DT.99992038 DT.121639778 24/385 AceView cDNA sequences (see all 385): AU130308 C20971 BE272338 BM916406 AW575117 BX367223 BM547505 BU557036 BM467981 BM720618 AI140015 AI304697 CR608547 BM724220 AA377039 CF454470 CA427223 BM811294 F06112 CA425739 F36835 CR613328 BI855669 BM722457
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BCKDK (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BCKDK
|
Expression
for BCKDK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BCKDK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCTGGGCA
About this image
See BCKDK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCKDK
SOURCE GeneReport for Unigene cluster: Hs.513520
UniProtKB/Swiss-Prot: BCKD_HUMAN, O14874Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for BCKDK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCKDK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCKDK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCKDK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCKDK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCKDK |
Orthologs
for BCKDK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for BCKDK gene from 4/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
BCKDK6 |
-- |
83(a) |
1 ↔ 1 |
GL343220.1(2194704-2206835) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.329942 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.53(n) |
|
BX855547.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.251592 |
Danio rerio mRNA similar to branched chain alpha-ketoacid more |
76.36(n) |
|
BC051774.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
PKP1(YIL042C)4
PKP11 |
Mitochondrial protein kinase involved in negative regulation more4
Pkp1p1 |
44.8(n)1
31.23(a)1 |
|
9(276292-275108)4
8547691, 4 NP_012222.11, 4 |
ENSEMBL Gene Tree for BCKDK (if available)
TreeFam Gene Tree for BCKDK (if available) |
Paralogs
for BCKDK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BCKDK gene
- PDK12 PDK42 PDK22 PDK32
2 SIMAP similar genes for BCKDK using alignment to 8 protein entries: BCKD_HUMAN (see all proteins):PDK1 PDK2
BCKDK for paralogs About GeneDecksing
|
Genomic Variants
for BCKDK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BCKDK (31117428 - 31124112 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BCKDK: --
Human Gene Mutation Database (HGMD): BCKDK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCKDK |
|
Disorders
/ Diseases
for BCKDK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BCKDK for disorders About GeneDecksing
OMIM gene information: 614901
OMIM disorders: --
UniProtKB/Swiss-Prot: BCKD_HUMAN, O14874
Defects in BCKDK are the cause of branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)[MIM:614923]. A metabolic disorder characterized by autism, epilepsy, intellectual disability, and reducedbranched-chain amino acids. Note=A diet enriched in branched amino acids (BCAAs) allows to normalize plasma BCAAlevels. This suggests that it may be possible to treat patients with mutations in BCKDK with BCAA supplementation
3  diseases for BCKDK: About MalaCardsmaple syrup urine disease protein s deficiency obesity
Human Genome Epidemiology (HuGE) Navigator: BCKDK (4 documents)
Export disorders for BCKDK gene to outside databases
|
Publications
for BCKDK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BCKDK gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with BCKDK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Regional assignment of two genes of the human branched-chain alpha-keto acid dehydrogenase complex: the E1 beta gene (BCKDHB) to chromosome 6p21-22 and the E2 gene (DBT) to chromosome 1p31. (PubMed id 1889817)1, 3 Zneimer S.M....Cox R.P. (1991)
- Regulation of the branched-chain alpha-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease. (PubMed id 2403034)1, 9 Harris R.A....Crabb D.W. (1990)
- Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. (PubMed id 22956686)2 Novarino G.... Gleeson J.G. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
|
External Searches for BCKDK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BCKDK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BCKDK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BCKDK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BCKDK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BCKDK gene:
Search GeneIP for patents involving BCKDK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BCKDK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BCKDK | | OriGene shRNA RFP for BCKDK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCKDK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCKDK | | | OriGene Protein Over-expression Lysate for BCKDK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BCKDK | | OriGene 3'-UTR Clone for BCKDK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCKDK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCKDK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BCKDK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BCKDK | | OriGene Custom Protein Services for BCKDK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCKDK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCKDK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCKDK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCKDK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCKDK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCKDK |
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| | | | Search Tocris compounds for BCKDK |
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 | | | BCKDK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCKDK |
|  |  |  |  | | | | ThermoFisher Antibodies for BCKDK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCKDK |
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