Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BCHE Gene

protein-coding   GIFtS: 72
GCID: GC03M165490

Butyrylcholinesterase

(Previous names: cholinesterase 1, cholinesterase (serum) 2)
(Previous symbols: CHE1, CHE2)
  See BCHE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
butyrylcholinesterase1 2     Choline Esterase II2 3
CHE11 2 3 5     EC 3.1.1.83 8
CHE21 2     E12
Cholinesterase (Serum) 21 2     cholinesterase2
Cholinesterase 11 2     pseudocholinesterase2
Acylcholine Acylhydrolase2 3     Pseudocholinesterase3
Butyrylcholine Esterase2 3     EC 3.1.18

External Ids:    HGNC: 9831   Entrez Gene: 5902   Ensembl: ENSG000001142007   OMIM: 1774005   UniProtKB: P062763   

Export aliases for BCHE gene to outside databases

Previous GC identifers: GC03M162635 GC03M166531 GC03M166892 GC03M166811 GC03M166973 GC03M162859


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BCHE Gene:
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain
prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia.
The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence
of the relaxant, the homozygote is at no known disadvantage. (provided by RefSeq, Jul 2008)

GeneCards Summary for BCHE Gene:
BCHE (butyrylcholinesterase) is a protein-coding gene. Diseases associated with BCHE include pseudocholinesterase deficiency, and amnestic disorder. GO annotations related to this gene include and identical protein binding. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: CHLE_HUMAN, P06276
Function: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter
acetylcholine. Can degrade neurotoxic organophosphate esters

summary for BCHE Gene:
Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and
acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst
butyrylcholinesterase (BChE) is mostly expressed in the liver.

Gene Wiki entry for BCHE (Butyrylcholinesterase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCHE gene promoter:
         Nkx3-1   Nkx3-1 v2   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCHE promoter sequence
   Search Chromatin IP Primers for BCHE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCHE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1-q26.2   Ensembl cytogenetic band:  3q26.1   HGNC cytogenetic band: 3q26.1-q26.2

BCHE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCHE gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M165490:  view genomic region     (about GC identifiers)

Start:
165,490,692 bp from pter      End:
165,555,260 bp from pter
Size:
64,569 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHLE_HUMAN, P06276 (See protein sequence)
Recommended Name: Cholinesterase precursor  
Size: 602 amino acids; 68418 Da
Subunit: Homotetramer; disulfide-linked. Dimer of dimers
Selected PDB 3D structures from and Proteopedia for BCHE (see all 38):
1EHO (3D)        1EHQ (3D)        1KCJ (3D)        1P0I (3D)        1P0M (3D)        1P0P (3D)    
Secondary accessions: A8K7P8

Explore the universe of human proteins at neXtProt for BCHE: NX_P06276

Explore proteomics data for BCHE at MOPED

Post-translational modifications: 

  • N-glycosylated. No other PTM detected (PubMed:20946535). The major N-glycan structures are of the complex
    diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of
    the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected
    (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the
    total N-glycans are of the oligomannosidic or hybrid type1
  • Glycosylation2 at Asn45, Asn85, Asn134, Asn269, Asn284, Asn369, Asn483, Asn509, Asn513, Asn514
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for BCHE (P06276) (see all 27)
     HGYEIEF  GVNKDEG  LALQWVQ  NIAAFGG 


    See BCHE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000046.1  
    ENSEMBL proteins: 
     ENSP00000264381   ENSP00000419505   ENSP00000419804   ENSP00000418325   ENSP00000418504  
     ENSP00000443583  
    Reactome Protein details: P06276

    BCHE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BCHE (Butyrylcholinesterase/BCHE)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for BCHE
    OriGene Protein Over-expression Lysate for BCHE
    OriGene MassSpec for BCHE
    OriGene Custom Protein Services for BCHE
    GenScript Custom Purified and Recombinant Proteins Services for BCHE
    Novus Biologicals BCHE Protein
    Novus Biologicals BCHE Lysate
    Sino Biological Recombinant Protein for BCHE
    Sino Biological Cell Lysate for BCHE
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCHE

     
    Search eBioscience for Proteins for BCHE 

    BCHE Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCHE
    Browse R&D Systems for Antibodies
    OriGene Antibodies for BCHE
    OriGene Custom Antibody Services for BCHE
    Novus Biologicals BCHE Antibodies
    Abcam antibodies for BCHE
    Cloud-Clone Corp. Antibodies for BCHE
    ThermoFisher Antibodies for BCHE
    LSBio Antibodies in human, mouse, rat for BCHE

    BCHE Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCHE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCHE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BCHE
    Cloud-Clone Corp. CLIAs for BCHE
    Search eBioscience for ELISAs for BCHE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR014788 AChE_tetra
     IPR000997 Cholinesterase
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry P06276

    ProtoNet protein and cluster: P06276

    1 Blocks protein domain: IPB000997 Cholinesterase signature

    UniProtKB/Swiss-Prot: CHLE_HUMAN, P06276
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    Find genes that share domains with BCHE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHLE_HUMAN, P06276
    Function: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter
    acetylcholine. Can degrade neurotoxic organophosphate esters
    Catalytic activity: An acylcholine + H(2)O = choline + a carboxylate
    Enzyme regulation: Inhibited by mercury. Inhibited by Tabun. Tabun forms a covalent adduct with Ser-226 that
    becomes irreversible upon aging

         Genatlas biochemistry entry for BCHE:
    butyryl cholinesterase,serum,with contradictory evidence for association of the K variant with Alzheimer
    disease,ApoE4 carrier

         Enzyme Numbers (IUBMB): EC 3.1.1.81 2 EC 3.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding NAS11569538
    GO:0003824catalytic activity NAS11569538
    GO:0003990acetylcholinesterase activity ISS--
    GO:0004104cholinesterase activity IDA19452557
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with BCHE           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bche):
     homeostasis/metabolism  mortality/aging  reproductive system 

    Find genes that share phenotypes with BCHE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bchetm1Loc for BCHE

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCHE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCHE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCHE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCHE

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCHE:
    hsa-mir-335-5p (MIRT018332), hsa-mir-26b-5p (MIRT029814)

    Block miRNA regulation of human, mouse, rat BCHE using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate BCHE:
    hsa-miR-16-2* hsa-miR-195* hsa-miR-1256 hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidBCHE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BCHE
    Predesigned siRNA for gene silencing in human, mouse, rat BCHE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCHE

    Clone
    Products:
         
    OriGene clones in human, mouse for BCHE (see all 7)
    OriGene ORF clones in mouse, rat for BCHE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCHE (NM_000055)
    Sino Biological Human cDNA Clone for BCHE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCHE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCHE

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCHE
    Browse ESI BIO Cell Lines and PureStem Progenitors for BCHE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCHE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CHLE_HUMAN, P06276: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum3
    cytoskeleton2
    mitochondrion2
    nucleus2
    plasma membrane2
    cytosol1
    golgi apparatus1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IBA--
    GO:0005641nuclear envelope lumen IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005788endoplasmic reticulum lumen IBA--

    Find genes that share ontologies with BCHE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BCHE About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    Irinotecan Pathway0.69
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neurotransmitter Clearance In The Synaptic Cleft0.00
    Neuronal System0.68
    3Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PC0.00
    Phospholipid metabolism0.64
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Synthesis, Secretion, and Deacylation of Ghrelin0.00


    Find genes that share SuperPaths with BCHE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for BCHE
        Irinotecan Pathway


    3 Reactome Pathways for BCHE
        Synthesis, secretion, and deacylation of Ghrelin
    Neurotransmitter Clearance In The Synaptic Cleft
    Synthesis of PC

    2 PharmGKB Pathways for BCHE
        Irinotecan Pathway, Pharmacodynamics
    Irinotecan Pathway, Pharmacokinetics

        Pathway & Disease-focused RT2 Profiler PCR Array including BCHE: 
              Alzheimer¬'s Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCHE

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for BCHE (P062761, 3 ENSP000002643814) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COLQQ9Y2153, ENSP000003732984I2D: score=2 STRING: ENSP00000373298
    BCHEP062761EBI-7936069,EBI-7936069
    GCGENSP000003876624STRING: ENSP00000387662
    IGF1ENSP000003026654STRING: ENSP00000302665
    INS-IGF2ENSP000003489864STRING: ENSP00000348986
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007271synaptic transmission, cholinergic IBA--
    GO:0007584response to nutrient ----
    GO:0007612learning IEA--
    GO:0008152metabolic process ----
    GO:0008285negative regulation of cell proliferation IEA--

    Find genes that share ontologies with BCHE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for BCHE available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Donepezil hydrochloridePotent AChE inhibitor[120011-70-3]
    PhenserineCholinesterase inhibitor[101246-66-6]
    Galanthamine hydrobromideCholinesterase inhibitor[1953-04-4]
    Rivastigmine tartrateDual AChE and BChE inhibitor[129101-54-8]
    AcephateAnticholinesterase insecticide[30560-19-1]

    Selected HMDB Compounds for BCHE (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    AcetylcholineACh (see all 7)51-84-3--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    DonepezilAricept (see all 3)120014-06-4--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--

    Selected DrugBank Compounds for BCHE (see all 66)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Rivastigmine-- 123441-03-2targetinhibitor19420308 18671661 12636181 19470293 11139819 19370562 16437532 11752352 18044073 14587496 11078030 19374459
    IsoflurophateDFP (see all 4)55-91-4targetinhibitor1511344 11405252 2361169 1776688 12459190
    enzymeinhibitor1511344 11405252 2361169 1776688 12459190 1511344 9359435 11405252 2361169 1776688 12459190
    MalathionCarbofos (see all 12)121-75-5targetinhibitor17364237 17139284 16782587 17016423 16716398 10592235
    ChloroprocaineChloroprocain (see all 3)133-16-4enzymesubstrate7081736 11305839 3111302 7425357 385208
    CholineBilineurine (see all 7)62-49-7targetproduct of17329059 16297435 17636231 17390078 16376069
    TacrineTetrahydroaminacrine (see all 5)321-64-2targetinhibitor12871155 17218977 10375753 16860785
    9-N-Phenylmethylamino-Tacrine-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    Beta-D-Mannose-- 7322-31-8target--17139284 17016423 10592235
    Chlorpromazine-- 50-53-3enzymeinhibitor12747580 12957233 1654884

    Selected Novoseek inferred chemical compound relationships for BCHE gene (see all 144)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butyrylthiocholine 95.4 40 8449554 (3), 10340441 (2), 8367669 (2), 1373381 (1) (see all 29)
    butyrylcholine 92.4 24 9191541 (2), 12501914 (2), 19714864 (2), 14711311 (1) (see all 17)
    benzoylcholine 91.6 10 14686935 (2), 15128307 (1), 20004171 (1), 10919342 (1) (see all 6)
    o-nitrophenyl butyrate 89.2 2 1390935 (1), 8314794 (1)
    rivastigmine 88.6 61 16212945 (4), 19617863 (2), 17047484 (2), 16191241 (1) (see all 48)
    acylcholine 88.2 7 2268667 (1), 2009086 (1), 1380483 (1), 1599981 (1) (see all 5)
    acetylthiocholine 87.3 26 8449554 (4), 10340441 (2), 8367669 (2), 15137175 (1) (see all 13)
    o-nitroacetanilide 86.7 4 16824479 (1), 18208347 (1)
    succinyldithiocholine 86.3 2 9047329 (1), 12603134 (1)
    echothiophate 86.2 10 17698511 (2), 15136175 (2), 15094306 (1), 9020776 (1) (see all 7)

    1 PharmGKB related drug/compound annotation for BCHE gene    About this table
    Drug/compound PharmGKB Annotation
    succinylcholine  CA  



    Find genes that share compounds with BCHE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BCHE gene: 
    NM_000055.2  

    Unigene Cluster for BCHE:

    Butyrylcholinesterase
    Hs.420483  [show with all ESTs]
    Unigene Representative Sequence: CD014090
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264381(uc003fem.4 uc003fen.4) ENST00000497011 ENST00000482958
    ENST00000479451 ENST00000488954 ENST00000540653
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BCHE using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate BCHE:
    hsa-miR-16-2* hsa-miR-195* hsa-miR-1256 hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidBCHE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BCHE
    Predesigned siRNA for gene silencing in human, mouse, rat BCHE
    Clone
    Products:
         
    OriGene clones in human, mouse for BCHE (see all 7)
    OriGene ORF clones in mouse, rat for BCHE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCHE (NM_000055)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCHE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCHE
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BCHE
    OriGene qSTAR qPCR primer pairs in human, mouse for BCHE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCHE
      QuantiTect SYBR Green Assays in human, mouse, rat BCHE
      QuantiFast Probe-based Assays in human, mouse, rat BCHE

    Additional mRNA sequence: 

    AK292063.1 BC008396.1 BC018141.1 M16474.1 M16541.1 

    23 DOTS entries:

    DT.313157  DT.95166895  DT.92461332  DT.95166782  DT.95166702  DT.92461340  DT.95166968  DT.95166838 
    DT.95166925  DT.95166971  DT.100825393  DT.92461339  DT.92461344  DT.92461348  DT.92461349  DT.92461355 
    DT.95166725  DT.95166766  DT.95166916  DT.95166922  DT.95253862  DT.92023343  DT.92461343 

    Selected AceView cDNA sequences (see all 276):

    CR612468 AL515531 CB153819 BP375392 BF514908 AU117425 BU194860 BQ636338 
    CR611139 BC018141 BG461334 BF056152 BG461330 BP357599 BX114451 BG459911 
    BG461806 BG460986 AV657113 BG461729 CB161794 BP378201 BG461801 CB163834 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BCHE    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                          -                           
    SP2:                                      -               
    SP3:                          -           -               
    SP4:                    -     -           -               


    ECgene alternative splicing isoforms for BCHE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BCHE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGACTGGA
    BCHE Expression
    About this image


    BCHE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced MEL2 cells
     
     Liver (Hepatobiliary System)
    BCHE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCHE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.420483

    UniProtKB/Swiss-Prot: CHLE_HUMAN, P06276
    Tissue specificity: Detected in blood plasma (at protein level). Present in most cells except erythrocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including BCHE: 
              Alzheimer¬'s Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BCHE
    OriGene qSTAR qPCR primer pairs in human, mouse for BCHE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCHE
    QuantiTect SYBR Green Assays in human, mouse, rat BCHE
    QuantiFast Probe-based Assays in human, mouse, rat BCHE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCHE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for BCHE gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bche1 , 5 butyrylcholinesterase1, 5 80.91(n)1
    80.3(a)1
      3 (33.61 cM)5
    120381  NM_009738.31  NP_033868.31 
     736358085 
    chicken
    (Gallus gallus)
    Aves BCHE1 butyrylcholinesterase 73.19(n)
    72.01(a)
      395358  NM_204646.1  NP_989977.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCHE6
    butyrylcholinesterase
    67(a)
    1 ↔ 1
    3(10250775-10312993)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004958891 cholinesterase-like 69.16(n)
    65.72(a)
      100495889  XM_002931564.2  XP_002931610.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60183 carboxylesterase 40(a)
    (best of 24)
      58E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea R173.33 esterase 42(a)
    (best of 27)
      X(7065997-7071293)   --


    ENSEMBL Gene Tree for BCHE (if available)
    TreeFam Gene Tree for BCHE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BCHE gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  
    NLGN22  CES12  CEL2  CES5A2  
    15 SIMAP similar genes for BCHE using alignment to 7 protein entries:     CHLE_HUMAN (see all proteins):
    ACHE    CES1P1    DKFZp686F02202    NLGN3    NLGN4X    TG
    CES8    CES2    CEL    CES hBr2    CES1    NLGN2
    CES5A    CES4A    CES3

    Find genes that share paralogs with BCHE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BCHE (see all 1552)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18032741,2,,4
    C,F,HButyrylcholinesterase deficiency (BChE deficiency)4 pathogenic1165354270(-) ATGAAG/ACAGAA 2 /T /A mis131Minor allele frequency- A:0.18EA NA NS CSA WA EU 8865
    rs289333901,2,,4
    C,FButyrylcholinesterase deficiency (BChE deficiency)4 pathogenic1165410655(-) CTTGGG/TTGATG 2 G V mis13Minor allele frequency- T:0.00EU NA 5969
    rs1151296871,2,,4
    C,FButyrylcholinesterase deficiency (BChE deficiency)4 --165410731(+) CTTTCC/GAAACT 2 R G mis11Minor allele frequency- G:0.01EA 208
    rs1219185571,2,,4
    CButyrylcholinesterase deficiency (BChE deficiency)4 pathogenic1165410836(-) CTTTTA/TTAGTC 2 I L mis10--------
    rs1156240851,2,,4
    CButyrylcholinesterase deficiency (BChE deficiency)4 --165411024(+) GATCTT/CTATTT 2 /K /R mis11Minor allele frequency- C:0.01EA 218
    rs289333891,2,,4
    C,FButyrylcholinesterase deficiency (BChE deficiency)4 pathogenic1165411096(-) CAGAAC/TGTTGA 2 T M mis1 ese33Minor allele frequency- T:0.00EU NA 5943
    rs37328801,2,,4
    C,F,HButyrylcholinesterase deficiency (BChE deficiency)4 --165411526(-) GGATTC/TCAGCA 2 P S mis1 ese36Minor allele frequency- T:0.01EA NS NA 658
    rs17998071,2,,4
    C,F,O,HButyrylcholinesterase deficiency (BChE deficiency)4 pathogenic1165411615(-) CATAGA/GTCAAA 2 D G mis1 ese313Minor allele frequency- G:0.01NA EA NS EU 6785
    rs563098531,2,,4
    CButyrylcholinesterase deficiency (BChE deficiency)4 --165411753(+) TTACCG/ATGCCA 2 /T /M mis12Minor allele frequency- A:0.00WA NA 4764
    VAR_0400344
    Butyrylcholinesterase deficiency (BChE deficiency)4--see VAR_0400342 R C mis40--------

    HapMap Linkage Disequilibrium report for BCHE (165490692 - 165555260 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for BCHE:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657931CNV Deletion23128226
    esv268149CNV Insertion20981092
    dgv5341n71CNV Loss21882294
    dgv5340n71CNV Loss21882294
    nsv877936CNV Loss21882294
    dgv5339n71CNV Loss21882294
    nsv428426CNV Loss18775914
    nsv877934CNV Gain21882294
    nsv520596CNV Gain+Loss19592680
    nsv877942CNV Gain+Loss21882294

    Human Gene Mutation Database (HGMD): BCHE
    Locus Specific Mutation Databases (LSDB): BCHE

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing BCHE:
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing BCHE
    DNA2.0 Custom Variant and Variant Library Synthesis for BCHE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 177400    OMIM disorders: --

    UniProtKB/Swiss-Prot: CHLE_HUMAN, P06276
  • Butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]: A metabolic disorder characterized by
    prolonged apnea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or
    mivacurium and other ester local anesthetics. The duration of the prolonged apnea varies significantly depending
    on the extent of the enzyme deficiency. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 8 diseases for BCHE:    
    About MalaCards
    pseudocholinesterase deficiency    amnestic disorder    anencephaly    hellp syndrome
    vascular dementia    cocaine abuse    dementia    alzheimer's disease

    7 diseases from the University of Copenhagen DISEASES database for BCHE:
    Alzheimer's disease     Myasthenia gravis     Brain disease     Liver disease
    Toxic encephalopathy     Vascular disease     Amnestic disorder

    Find genes that share disorders with BCHE           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BCHE gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudocholinesterase deficiency 92.9 26 17805000 (4), 17613911 (3), 15905758 (2), 10614702 (2) (see all 17)
    alzheimers disease 77.1 150 17681768 (4), 15510242 (3), 17553629 (3), 16275899 (2) (see all 93)
    poisoning 65.9 37 18937214 (3), 19428953 (3), 2379248 (2), 20398460 (2) (see all 18)
    cocaine intoxication 56.2 4 9266811 (1), 9673783 (1), 9266810 (1), 9882701 (1)
    dementia 53.7 42 12668920 (3), 1469405 (2), 7979218 (2), 12796550 (2) (see all 25)
    spina bifida open 52.8 3 7647148 (2), 1705434 (1)
    senile plaques 52.6 16 9165483 (2), 9403484 (2), 10893490 (1), 7979218 (1) (see all 12)
    intoxication 48.9 7 18076380 (1), 10437130 (1), 14600276 (1), 19586353 (1) (see all 7)
    neurofibrillary tangles 46.1 8 8004445 (2), 10893490 (1), 8792327 (1), 8239315 (1) (see all 5)
    dementia vascular 36.5 3 12417373 (1), 15219807 (1), 15633941 (1)

    Genatlas disease: BCHE
    apnea,postanesthetic,suxamethonium sensitivity,hypocholinesterasemia or acholinesterasemia

    Genetic Association Database (GAD): BCHE
    Human Genome Epidemiology (HuGE) Navigator: BCHE (68 documents)

    Export disorders for BCHE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BCHE gene, integrated from 10 sources (see all 971):
    (articles sorted by number of sources associating them with BCHE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India. (PubMed id 16788378)1, 2, 4, 9 Manoharan I.... Boopathy R. (Pharmacogenet. Genomics 2006)
    2. Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population. (PubMed id 12881446)1, 2, 4, 9 Yen T.... Stewart P.M. (Clin. Chem. 2003)
    3. The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26. (PubMed id 1769657)1, 3, 9 Allderdice P.W....McAlpine P.J. (Genomics 1991)
    4. Association of variants of the -116 site of the butyrylcholinesterase BCHE gene to enzyme activity and body mass index. (PubMed id 18550040)1, 4, 9 Furtado-Alle L....Chautard-Freire-Maia E.A. (Chem. Biol. Interact. 2008)
    5. Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase. (PubMed id 17768338)1, 2, 9 Ngamelue M.N.... Asojo O.A. (Acta Crystallogr. F 2007)
    6. Possible influence of BCHE locus of butyrylcholinesterase on stature and body mass index. (PubMed id 15386241)1, 4, 9 Souza R.L....Chautard-Freire-Maia E.A. (Am. J. Phys. Anthropol. 2005)
    7. Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia. (PubMed id 18075469)1, 2, 9 Gaetke M.R.... Viby-Mogensen J. (Pharmacogenet. Genomics 2007)
    8. Butyrylcholinesterase, ApoE and Alzheimer's disease in a population from the Canary Islands (Spain). (PubMed id 17923322)1, 4, 9 DAcniz-Naranjo M.C....SA!nchez-GarcA-a F. (Neurosci. Lett. 2007)
    9. Interaction of human butyrylcholinesterase variants with bambuterol and terbutaline. (PubMed id 15449725)1, 7, 9 Kovarik Z. and Simeon-Rudolf V. (J Enzyme Inhib Med Chem 2004)
    10. Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. (PubMed id 12869558)1, 2, 9 Nicolet Y.... Nachon F. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 590 HGNC: 983 AceView: BCHE Ensembl:ENSG00000114200 euGenes: HUgn590
    ECgene: BCHE H-InvDB: BCHE

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BCHE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCHE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BCHE gene:
    Search GeneIP for patents involving BCHE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BCHE
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for BCHE (Butyrylcholinesterase/BCHE)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BCHE   OriGene RNAi products in human, mouse, rat for BCHE  
     OriGene qPCR primer pairs and template standards for BCHE   OriGene Protein Over-expression Lysate for BCHE  
     OriGene MassSpec something-or-other for BCHE   OriGene clones in human, mouse for BCHE  
     OriGene qSTAR qPCR primer pairs in human, mouse for BCHE   OriGene Purified Protein for BCHE  
     OriGene ORF clones in mouse, rat for BCHE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCHE   OriGene Custom Protein Services for BCHE  

     
     
     Block miRNA regulation of human, mouse, rat BCHE using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BCHE
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCHE Predesigned siRNA for gene silencing in human, mouse, rat BCHE
     QuantiFast Probe-based Assays in human, mouse, rat BCHE QuantiTect SYBR Green Assays in human, mouse, rat BCHE
     PCR Arrays including human, mouse, rat BCHE Search Chromatin IP Primers for BCHE
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCHE  GeneGlobe Interaction Network for BCHE
     Regulatory tfbs in BCHE promoter
     GenScript Custom Purified and Recombinant Proteins Services for BCHE GenScript cDNA clones with any tag delivered in your preferred vector for BCHE
     GenScript Custom Assay Services for BCHE GenScript Custom overexpressing Cell Line Services for BCHE
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for BCHE
     Proteins for BCHE
     Cell Lysates for BCHE
     cDNA Clones for BCHE
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BCHE antibodies
     BCHE proteins
     BCHE lysates
     Antibodies for BCHE
     See all of Abcam's Antibodies, Kits and Proteins for BCHE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BCHE
     Antibodies for BCHE
     ELISAs for BCHE
     CLIAs for BCHE



     Browse ESI BIO Cell Lines and PureStem Progenitors for BCHE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCHE
     SwitchGear 3'UTR luciferase reporter plasmids for BCHE
     SwitchGear Promoter luciferase reporter plasmids for BCHE
     ThermoFisher Antibodies for BCHE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCHE
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCHE
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCHE
     LSBio Antibodies in human, mouse, rat for BCHE
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BCHE
      Search eBioscience for proteins for BCHE
      Search eBioscience for elisas for BCHE
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCHE gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4