Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BCDIN3D Gene

Aliases for BCDIN3D Gene

  • BCDIN3 Domain Containing 2 3
  • BCDIN3 Domain-Containing Protein 4
  • EC 2.1.1.- 4
  • EC 2.1.1 64

External Ids for BCDIN3D Gene

Summaries for BCDIN3D Gene

GeneCards Summary for BCDIN3D Gene

BCDIN3D (BCDIN3 Domain Containing) is a Protein Coding gene. GO annotations related to this gene include O-methyltransferase activity and RNA methyltransferase activity.

UniProtKB/Swiss-Prot for BCDIN3D Gene

  • O-methyltransferase that specifically dimethylates the 5 monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5 monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCDIN3D Gene

Genomics for BCDIN3D Gene

Genomic Location for BCDIN3D Gene

Start:
49,836,039 bp from pter
End:
49,843,129 bp from pter
Size:
7,091 bases
Orientation:
Minus strand

Genomic View for BCDIN3D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCDIN3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCDIN3D Gene

Regulatory Elements for BCDIN3D Gene

Proteins for BCDIN3D Gene

  • Protein details for BCDIN3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5W3-BN3D2_HUMAN
    Recommended name:
    Pre-miRNA 5-monophosphate methyltransferase
    Protein Accession:
    Q7Z5W3
    Secondary Accessions:
    • A8K829

    Protein attributes for BCDIN3D Gene

    Size:
    292 amino acids
    Molecular mass:
    33200 Da
    Quaternary structure:
    • Interacts with DICER1; the interaction may be mediated by RNA.

neXtProt entry for BCDIN3D Gene

Proteomics data for BCDIN3D Gene at MOPED

Selected DME Specific Peptides for BCDIN3D Gene

Post-translational modifications for BCDIN3D Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys143

Other Protein References for BCDIN3D Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for BCDIN3D Gene

Protein Domains for BCDIN3D Gene

UniProtKB/Swiss-Prot:

BN3D2_HUMAN
Domain:
  • Contains 1 Bin3-type SAM domain.:
    • Q7Z5W3
Family:
  • Belongs to the methyltransferase superfamily.:
    • Q7Z5W3
genes like me logo Genes that share domains with BCDIN3D: view

No data available for Gene Families for BCDIN3D Gene

Function for BCDIN3D Gene

Molecular function for BCDIN3D Gene

UniProtKB/Swiss-Prot Function: O-methyltransferase that specifically dimethylates the 5 monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5 monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs.

Enzyme Numbers (IUBMB) for BCDIN3D Gene

Gene Ontology (GO) - Molecular Function for BCDIN3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity --
GO:0008171 O-methyltransferase activity IDA 23063121
GO:0008173 RNA methyltransferase activity IDA 23063121
genes like me logo Genes that share ontologies with BCDIN3D: view

Phenotypes for BCDIN3D Gene

GenomeRNAi human phenotypes for BCDIN3D:
genes like me logo Genes that share phenotypes with BCDIN3D: view

miRNA for BCDIN3D Gene

miRTarBase miRNAs that target BCDIN3D

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for BCDIN3D Gene

Localization for BCDIN3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCDIN3D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCDIN3D Gene COMPARTMENTS Subcellular localization image for BCDIN3D gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BCDIN3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BCDIN3D: view

Pathways for BCDIN3D Gene

SuperPathways for BCDIN3D Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCDIN3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation IDA 23063121
GO:0010586 miRNA metabolic process IDA 23063121
GO:2000632 negative regulation of pre-miRNA processing IDA 23063121
genes like me logo Genes that share ontologies with BCDIN3D: view

No data available for Pathways by source for BCDIN3D Gene

Transcripts for BCDIN3D Gene

mRNA/cDNA for BCDIN3D Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BCDIN3D Gene

BCDIN3 domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCDIN3D Gene

No ASD Table

Relevant External Links for BCDIN3D Gene

GeneLoc Exon Structure for
BCDIN3D
ECgene alternative splicing isoforms for
BCDIN3D

Expression for BCDIN3D Gene

mRNA expression in normal human tissues for BCDIN3D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCDIN3D Gene

SOURCE GeneReport for Unigene cluster for BCDIN3D Gene Hs.142736

genes like me logo Genes that share expressions with BCDIN3D: view

Orthologs for BCDIN3D Gene

This gene was present in the common ancestor of animals.

Orthologs for BCDIN3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCDIN3D 36
  • 99.54 (n)
  • 99.32 (a)
BCDIN3D 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCDIN3D 36
  • 88.58 (n)
  • 86.64 (a)
BCDIN3D 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCDIN3D 36
  • 88.74 (n)
  • 87.59 (a)
BCDIN3D 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcdin3d 36
  • 81.68 (n)
  • 80.14 (a)
Bcdin3d 16
Bcdin3d 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCDIN3D 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCDIN3D 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcdin3d 36
  • 82.97 (n)
  • 81.52 (a)
chicken
(Gallus gallus)
Aves BCDIN3D 36
  • 66.93 (n)
  • 67.47 (a)
BCDIN3D 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCDIN3D 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69172 36
tropical clawed frog
(Silurana tropicalis)
Amphibia bcdin3d 36
  • 60.36 (n)
  • 61.76 (a)
Str.4217 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9002 36
zebrafish
(Danio rerio)
Actinopterygii bcdin3d 37
  • 48 (a)
OneToOne
LOC568375 36
  • 56.54 (n)
  • 53.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11342 36
  • 46.42 (n)
  • 38.36 (a)
CG11342 37
  • 37 (a)
OneToOne
Species with no ortholog for BCDIN3D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCDIN3D Gene

ENSEMBL:
Gene Tree for BCDIN3D (if available)
TreeFam:
Gene Tree for BCDIN3D (if available)

Paralogs for BCDIN3D Gene

No data available for Paralogs for BCDIN3D Gene

Variants for BCDIN3D Gene

Sequence variations from dbSNP and Humsavar for BCDIN3D Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7134749 -- 49,843,854(+) AGGAT(C/T)CGAAC upstream-variant-2KB
rs7307673 -- 49,844,421(+) GAGAT(A/G)GAGTC upstream-variant-2KB
rs11169175 -- 49,842,745(+) TATAC(C/T)CGTTT intron-variant
rs34150711 -- 49,842,775(+) GTTAG(-/C)CCAGG intron-variant
rs34546759 -- 49,843,035(+) CTCTT(-/A)CCGCT reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for BCDIN3D Gene

Variant ID Type Subtype PubMed ID
nsv522972 CNV Gain 19592680

Relevant External Links for BCDIN3D Gene

HapMap Linkage Disequilibrium report
BCDIN3D

Disorders for BCDIN3D Gene

Relevant External Links for BCDIN3D

Genetic Association Database (GAD)
BCDIN3D
Human Genome Epidemiology (HuGE) Navigator
BCDIN3D
genes like me logo Genes that share disorders with BCDIN3D: view

No data available for UniProtKB/Swiss-Prot for BCDIN3D Gene

Publications for BCDIN3D Gene

  1. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PMID: 19079260) Thorleifsson G. … Stefansson K. (Nat. Genet. 2009) 3 49
  2. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. (PMID: 19557197) Heard-Costa N.L. … North K.E. (PLoS Genet. 2009) 3 49
  3. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PMID: 20215397) Ng M.C. … Ma R.C. (J. Clin. Endocrinol. Metab. 2010) 3 49
  4. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (PMID: 20712903) Morgan A.R. … Mitchell E.A. (BMC Med. Genet. 2010) 3 49
  5. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PMID: 20724581) den Hoed M. … Loos R.J. (Diabetes 2010) 3 49

Products for BCDIN3D Gene

Sources for BCDIN3D Gene

Back to Top

Content