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Aliases for BCCIP Gene

Aliases for BCCIP Gene

  • BRCA2 And CDKN1A Interacting Protein 2 3
  • TOK1 3 4 6
  • BRCA2 And CDKN1A-Interacting Protein 2 3
  • P21- And CDK-Associated Protein 1 3 4
  • Protein TOK-1 3 4
  • BRCA2 And Cip1/P21 Interacting Protein 3
  • Cdk Inhibitor P21 Binding Protein 3
  • BCCIPalpha 3
  • TOK-1alpha 3
  • BCCIPbeta 3
  • TOK-1beta 3
  • TOK-1 3

External Ids for BCCIP Gene

Previous GeneCards Identifiers for BCCIP Gene

  • GC10P126487
  • GC10P126715
  • GC10P127553
  • GC10P127086
  • GC10P127502
  • GC10P121201

Summaries for BCCIP Gene

Entrez Gene Summary for BCCIP Gene

  • This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCCIP Gene

BCCIP (BRCA2 And CDKN1A Interacting Protein) is a Protein Coding gene. Diseases associated with BCCIP include breast cancer. GO annotations related to this gene include kinase regulator activity.

UniProtKB/Swiss-Prot for BCCIP Gene

  • May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

Gene Wiki entry for BCCIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCCIP Gene

Genomics for BCCIP Gene

Regulatory Elements for BCCIP Gene

Genomic Location for BCCIP Gene

125,823,535 bp from pter
125,853,695 bp from pter
30,161 bases
Plus strand

Genomic View for BCCIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCCIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCCIP Gene

Proteins for BCCIP Gene

  • Protein details for BCCIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRCA2 and CDKN1A-interacting protein
    Protein Accession:
    Secondary Accessions:
    • B3KP45
    • Q8ND15
    • Q96GC4
    • Q9P288

    Protein attributes for BCCIP Gene

    314 amino acids
    Molecular mass:
    35979 Da
    Quaternary structure:
    • Interacts with BRCA2, CDKN1A and MTDH/LYRIC.
    • HT1080 cells that constitutively express low levels of BCCIP display increased levels of spontaneous single-stranded DNA and double-strand breaks

    Alternative splice isoforms for BCCIP Gene


neXtProt entry for BCCIP Gene

Proteomics data for BCCIP Gene at MOPED

Post-translational modifications for BCCIP Gene

  • Ubiquitination at Lys76, Lys84, Lys137, Lys174, and Lys201
  • Modification sites at PhosphoSitePlus

Other Protein References for BCCIP Gene

No data available for DME Specific Peptides for BCCIP Gene

Domains for BCCIP Gene

Protein Domains for BCCIP Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9P287
  • Belongs to the BCP1 family.
genes like me logo Genes that share domains with BCCIP: view

No data available for Gene Families for BCCIP Gene

Function for BCCIP Gene

Molecular function for BCCIP Gene

UniProtKB/Swiss-Prot Function: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

Gene Ontology (GO) - Molecular Function for BCCIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019207 kinase regulator activity IDA 10878006
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BCCIP: view
genes like me logo Genes that share phenotypes with BCCIP: view

miRNA for BCCIP Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BCCIP Gene

Localization for BCCIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCCIP Gene

Nucleus. Note=Colocalizes with BRCA2 in discrete nuclear foci.

Subcellular locations from

Jensen Localization Image for BCCIP Gene COMPARTMENTS Subcellular localization image for BCCIP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for BCCIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10878006
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex IDA 10878006
genes like me logo Genes that share ontologies with BCCIP: view

Pathways for BCCIP Gene

SuperPathways for BCCIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCCIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 10878006
GO:0006281 DNA repair IEA --
GO:0007049 cell cycle IEA --
GO:0061101 neuroendocrine cell differentiation IDA 18440304
genes like me logo Genes that share ontologies with BCCIP: view

No data available for Pathways by source for BCCIP Gene

Transcripts for BCCIP Gene

Unigene Clusters for BCCIP Gene

BRCA2 and CDKN1A interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCCIP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for BCCIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCCIP Gene

mRNA expression in normal human tissues for BCCIP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCCIP Gene

SOURCE GeneReport for Unigene cluster for BCCIP Gene Hs.715543

mRNA Expression by UniProt/SwissProt for BCCIP Gene

Tissue specificity: Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
genes like me logo Genes that share expressions with BCCIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCCIP Gene

Orthologs for BCCIP Gene

This gene was present in the common ancestor of animals.

Orthologs for BCCIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCCIP 35
  • 99.58 (n)
  • 98.73 (a)
  • 98 (a)
(Bos Taurus)
Mammalia BCCIP 35
  • 88.72 (n)
  • 88.33 (a)
  • 69 (a)
(Canis familiaris)
Mammalia BCCIP 35
  • 83.76 (n)
  • 80.89 (a)
  • 68 (a)
(Mus musculus)
Mammalia Bccip 35
  • 85.73 (n)
  • 83.27 (a)
Bccip 16
Bccip 36
  • 67 (a)
(Monodelphis domestica)
Mammalia BCCIP 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia BCCIP 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Bccip 35
  • 84.7 (n)
  • 82.49 (a)
(Gallus gallus)
Aves BCCIP 35
  • 76.43 (n)
  • 76.95 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia BCCIP 36
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6157 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bccip 35
  • 71.61 (n)
  • 74.61 (a)
Str.157 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9378 35
(Danio rerio)
Actinopterygii bccip 35
  • 63.12 (n)
  • 57.09 (a)
bccip 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003476 35
  • 48.51 (n)
  • 35.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9286 35
  • 46.21 (n)
  • 34.96 (a)
CG9286 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5244 36
  • 32 (a)
Species with no ortholog for BCCIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCCIP Gene

Gene Tree for BCCIP (if available)
Gene Tree for BCCIP (if available)

Paralogs for BCCIP Gene

No data available for Paralogs for BCCIP Gene

Variants for BCCIP Gene

Sequence variations from dbSNP and Humsavar for BCCIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1891360 -- 125,835,599(-) ttttt(G/T)tttgt intron-variant
rs1891361 -- 125,835,390(-) gtgtt(A/G)gccag intron-variant
rs2185740 -- 125,834,419(-) GGAGA(A/T)ATCCC intron-variant
rs2366040 -- 125,831,860(+) TTCAT(A/G)TAGAC intron-variant
rs3034779 -- 125,834,835(+) AAAAA(-/AAA/AAAA/AAAAA/AACA)CACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCCIP Gene

Variant ID Type Subtype PubMed ID
nsv428241 CNV Loss 18775914
dgv324e1 CNV Complex 17122850
nsv8736 CNV Loss 18304495
esv259478 OTHER Complex 20981092
esv259818 OTHER Complex 20981092
esv4748 CNV Duplication 18987735
nsv8737 CNV Loss 18304495

Relevant External Links for BCCIP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCCIP Gene

Disorders for BCCIP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BCCIP Gene including...

Search for BCCIP Gene in MalaCards »

(2) Novoseek inferred disease relationships for BCCIP Gene

Disease -log(P) Hits PubMed IDs
cancer 23.7 4
tumors 11.2 6

Relevant External Links for BCCIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BCCIP: view

No data available for UniProtKB/Swiss-Prot for BCCIP Gene

Publications for BCCIP Gene

  1. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. (PMID: 11313963) Liu J. … Shen Z. (Oncogene 2001) 2 3 4 23
  2. Genomic structure of the human BCCIP gene and its expression in cancer. (PMID: 12527204) Meng X. … Shen Z. (Gene 2003) 3 4 23
  3. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. (PMID: 15539944) Meng X. … Shen Z. (Cell Cycle 2004) 3 4 23
  4. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. (PMID: 15713648) Lu H. … Shen Z. (Mol. Cell. Biol. 2005) 3 4 23
  5. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. (PMID: 10878006) Ono T. … Ariga H. (J. Biol. Chem. 2000) 2 3 4

Products for BCCIP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Cycle in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate BCCIP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for BCCIP
  • Block miRNA regulation of BCCIP using miScript Target Protectors

Sources for BCCIP Gene

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