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BCCIP Gene

protein-coding   GIFtS: 52
GCID: GC10P127502

BRCA2 And CDKN1A Interacting Protein

(Previous name: BRCA2 and CDKN1A-interacting protein)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BRCA2 And CDKN1A Interacting Protein1 2     BCCIPbeta2
TOK12 3 5     TOK-12
BRCA2 And CDKN1A-Interacting Protein1 2     TOK-1alpha2
P21- And CDK-Associated Protein 12 3     TOK-1beta2
Protein TOK-12 3     BRCA2 And Cip1/P21 Interacting Protein2
BCCIPalpha2     Cdk Inhibitor P21 Binding Protein2

External Ids:    HGNC: 9781   Entrez Gene: 566472   Ensembl: ENSG000001079497   OMIM: 6118835   UniProtKB: Q9P2873   

Export aliases for BCCIP gene to outside databases

Previous GC identifers: GC10P126487 GC10P126715 GC10P127553 GC10P127086 GC10P121201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCCIP Gene:
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an
evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate
homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies
indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2
kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus
formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript
variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BCCIP Gene:
BCCIP (BRCA2 and CDKN1A interacting protein) is a protein-coding gene. GO annotations related to this gene include kinase regulator activity.

UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287
Function: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required
for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in
non-homologous end joining (NHEJ)

Gene Wiki entry for BCCIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the BCCIP gene promoter:
         Sox5   Elk-1   SREBP-1c   HNF-3beta   Evi-1   SREBP-1b   E47   SREBP-1a   HSF2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCCIP promoter sequence
   Search Chromatin IP Primers for BCCIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCCIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.1   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26.2

BCCIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCCIP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P127502:  view genomic region     (about GC identifiers)

Start:
127,512,104 bp from pter      End:
127,542,264 bp from pter
Size:
30,161 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287 (See protein sequence)
Recommended Name: BRCA2 and CDKN1A-interacting protein  
Size: 314 amino acids; 35979 Da
Subunit: Interacts with BRCA2, CDKN1A and MTDH/LYRIC
Developmental stage: Isoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis
and peaks in the G1/S phase of the cell cycle
Miscellaneous: HT1080 cells that constitutively express low levels of BCCIP display increased levels of
spontaneous single-stranded DNA and double-strand breaks
Secondary accessions: B3KP45 Q8ND15 Q96GC4 Q9P288
Alternative splicing: 4 isoforms:  Q9P287-1   Q9P287-2   Q9P287-3   Q9P287-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCCIP: NX_Q9P287

Explore proteomics data for BCCIP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76, Lys84, Lys137, Lys174, Lys201
  • Modification sites at PhosphoSitePlus

  • See BCCIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_057651.1  NP_510868.1  NP_510869.1  

    ENSEMBL proteins: 
     ENSP00000278100   ENSP00000299130   ENSP00000357748   ENSP00000394758  

    BCCIP Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for BCCIP
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    Cloud-Clone Corp. Proteins for BCCIP

     
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    antibodies-online proteins for BCCIP (6 products) 

     
    Search antibodies-online for peptides for BCCIP

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    antibodies-online antibodies for BCCIP (29 products) 

    BCCIP Assay Products:

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    Search eBioscience for ELISAs for BCCIP 
    antibodies-online kits for BCCIP (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR025602 BCP1_family

    Graphical View of Domain Structure for InterPro Entry Q9P287

    ProtoNet protein and cluster: Q9P287

    UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287
    Similarity: Belongs to the BCP1 family


    Find genes that share domains with BCCIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCCIP_HUMAN, Q9P287
    Function: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required
    for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in
    non-homologous end joining (NHEJ)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18440304
    GO:0019207kinase regulator activity IDA10878006
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with BCCIP           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for BCCIP:
     Decreased viability of wild-ty  Increased G1 DNA content  Increased cell number in S and 

         1 MGI phenotypic allele for Bccip (no phenotypes)

    Find genes that share phenotypes with BCCIP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BCCIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCCIP:
    hsa-mir-423-5p (MIRT038174), hsa-mir-7-5p (MIRT025700), hsa-mir-124-3p (MIRT022455), hsa-mir-30c-5p (MIRT048007), hsa-mir-16-5p (MIRT031532)

    Block miRNA regulation of human, mouse, rat BCCIP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate BCCIP:
    hsa-miR-3674
    SwitchGear 3'UTR luciferase reporter plasmidBCCIP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BCCIP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): BCCIP (NM_078468)
    Sino Biological Human cDNA Clone for BCCIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCCIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCCIP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCCIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BCCIP_HUMAN, Q9P287: Nucleus. Note=Colocalizes with BRCA2 in discrete nuclear foci
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10878006
    GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex IDA10878006

    Find genes that share ontologies with BCCIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including BCCIP: 
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCCIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCCIP (Q9P2872, 3 ENSP000003577484) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253044 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253044 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253044 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253044 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253044 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IDA10878006
    GO:0006281DNA repair IEA--
    GO:0007049cell cycle IEA--
    GO:0061101neuroendocrine cell differentiation IDA18440304

    Find genes that share ontologies with BCCIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCCIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BCCIP gene (3 alternative transcripts): 
    NM_016567.3  NM_078468.2  NM_078469.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278100(uc021qar.1 uc001ljb.4) ENST00000299130(uc001ljc.4 uc010quj.2)
    ENST00000368759(uc001ljd.4) ENST00000463330 ENST00000478798 ENST00000429863

    miRNA
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    Block miRNA regulation of human, mouse, rat BCCIP using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate BCCIP:
    hsa-miR-3674
    SwitchGear 3'UTR luciferase reporter plasmidBCCIP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BCCIP
    Predesigned siRNA for gene silencing in human, mouse, rat BCCIP
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    GenScript: all cDNA clones in your preferred vector (see all 3): BCCIP (NM_078468)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCCIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCCIP
    Primer
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    OriGene qPCR primer pairs and template standards for BCCIP
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      QuantiTect SYBR Green Assays in human, mouse, rat BCCIP
      QuantiFast Probe-based Assays in human, mouse, rat BCCIP

    Selected AceView cDNA sequences (see all 393):

    CF145778 BE677520 BU622241 CB157900 AI818394 AL531223 BM680270 AW007523 
    AI806027 BM716747 BM054941 CB135545 BM142468 NM_078468 AW510624 BM055187 
    BE048851 BU753530 CR626197 BM823204 CB215255 AA977824 BE504980 BM455049 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BCCIP (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                    -                                                   
    SP2:              -     -                                                   
    SP3:                    -                 -     -     -                     
    SP4:                    -                 -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for BCCIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCCIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTCGTAAT
    BCCIP Expression
    About this image

    BCCIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCCIP Protein Expression

    UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287
    Tissue specificity: Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart,
    kidney, liver, lung, ovary, pancreas, placenta, and spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including BCCIP: 
              Cell Cycle in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCCIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BCCIP gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bccip1 , 5 BRCA2 and CDKN1A interacting protein1, 5 85.73(n)1
    83.27(a)1
      7 (77.30 cM)5
    661651  NM_025392.21  NP_079668.21 
     1337093335 
    chicken
    (Gallus gallus)
    Aves BCCIP1 BRCA2 and CDKN1A interacting protein 76.43(n)
    76.95(a)
      426225  XM_423888.4  XP_423888.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCCIP6
    BRCA2 and CDKN1A interacting protein
    54(a)
    1 ↔ 1
    3(63048317-63062318)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61572 Xenopus laevis transcribed sequence with moderate similarity more 75.8(n)    CD325208.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bccip1 BRCA2 and CDKN1A interacting protein 63.12(n)
    57.09(a)
      541348  NM_001013475.2  NP_001013493.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92861 CG9286 46.21(n)
    34.96(a)
      41690  NM_142060.4  NP_650317.3 


    ENSEMBL Gene Tree for BCCIP (if available)
    TreeFam Gene Tree for BCCIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCCIP (see all 648)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133871331,2
    C--121213448(+) AAAAAA/CAAACA 3 -- int10--------
    rs753918381,2
    C,F--127513983(+) CCTGAA/GTAATG 3 -- int11Minor allele frequency- G:0.02WA 118
    rs1451208101,2
    --127514011(+) TTAGTG/TTGATC 3 -- int10--------
    rs1135416841,2
    F--127514023(+) TGTTTG/CGAACA 3 -- int11Minor allele frequency- C:0.50CSA 2
    rs122441561,2
    --127514150(+) CCAGGC/GCCTTG 3 -- int10--------
    rs1175266751,2
    F--127514404(+) TTGGCA/GTTTTA 3 -- int11Minor allele frequency- G:0.05EA 120
    rs796051611,2
    C--127514535(+) TGTTCC/TCTGTA 3 -- int11Minor allele frequency- T:0.01NA 120
    rs1879274721,2
    C--127514566(+) TTCTCA/C/GGTTTC 3 -- int10--------
    rs1436638211,2
    C--127514919(+) TTGTAA/GTCAGG 3 -- int10--------
    rs1510553581,2
    --127515016(+) TGTTTC/TCTCAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for BCCIP (127512104 - 127542264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for BCCIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4748CNV Duplication18987735
    nsv8736CNV Loss18304495
    nsv428241CNV Loss18775914
    nsv8737CNV Loss18304495
    dgv324e1CNV Complex17122850
    esv259818OTHER Complex20981092
    esv259478OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCCIP
    DNA2.0 Custom Variant and Variant Library Synthesis for BCCIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611883    OMIM disorders: --


    Find genes that share disorders with BCCIP           About GenesLikeMe

    2 Novoseek inferred disease relationships for BCCIP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 23.7 7 11313963 (2), 12527204 (1), 19653894 (1)
    tumors 11.2 7 19653894 (3), 12527204 (2), 11313963 (1)

    Genetic Association Database (GAD): BCCIP
    Human Genome Epidemiology (HuGE) Navigator: BCCIP (3 documents)

    Export disorders for BCCIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCCIP gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with BCCIP)
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    1. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. (PubMed id 11313963)1, 2, 3, 9 Liu J.... Shen Z. (Oncogene 2001)
    2. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. (PubMed id 10878006)1, 2, 3 Ono T.... Ariga H. (J. Biol. Chem. 2000)
    3. Genomic structure of the human BCCIP gene and its expression in cancer. (PubMed id 12527204)1, 2, 9 Meng X.... Shen Z. (Gene 2003)
    4. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. (PubMed id 15539944)1, 2, 9 Meng X.... Shen Z. (Cell Cycle 2004)
    5. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. (PubMed id 15713648)1, 2, 9 Lu H....Shen Z. (Mol. Cell. Biol. 2005)
    6. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    7. New common variants affecting susceptibility to basal cell carcinoma. (PubMed id 19578363)1, 4 Stacey S.N....Stefansson K. (Nat. Genet. 2009)
    8. Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes. (PubMed id 19861517)1, 4 Luedeke M....Maier C. (amp 2009)
    9. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. (PubMed id 18440304)1, 2 Ash S.C.... Britt D.E. (Biochem. Biophys. Res. Commun. 2008)
    10. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. (PubMed id 17947333)1, 2 Lu H.... Shen Z. (Nucleic Acids Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56647 HGNC: 978 AceView: BCCIP Ensembl:ENSG00000107949 euGenes: HUgn56647
    ECgene: BCCIP H-InvDB: BCCIP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BCCIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCCIP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCCIP gene:
    Search GeneIP for patents involving BCCIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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