Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCCIP Gene

protein-coding   GIFtS: 52
GCID: GC10P127502

BRCA2 and CDKN1A interacting protein

(Previous name: BRCA2 and CDKN1A-interacting protein )
 Explore 14 diseases affiliated with
BCCIP via our new
 Human Malady Compendium 
Biological research products
for BCCIP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
BRCA2 And CDKN1A Interacting Protein1 2     Protein TOK-12 3
TOK12 3 5     BCCIPbeta2
BCCIPalpha1 2     TOK-1alpha2
TOK-11 2     TOK-1beta2
BRCA2 And CDKN1A-Interacting Protein1 2     BRCA2 And Cip1/P21 Interacting Protein2
P21- And CDK-Associated Protein 12 3     Cdk Inhibitor P21 Binding Protein2

External Ids:    HGNC: 9781   Entrez Gene: 566472   Ensembl: ENSG000001079497   OMIM: 6118835   UniProtKB: Q9P2873   

Export aliases for BCCIP gene to outside databases

Previous GC identifers: GC10P126487 GC10P126715 GC10P127553 GC10P127086 GC10P121201


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCCIP:
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily
conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions
of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein
may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This
protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand
break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different
isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287
Function: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for
repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end
joining (NHEJ)

Gene Wiki entry for BCCIP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCCIP gene promoter:
         Sox5   Elk-1   SREBP-1c   HNF-3beta   Evi-1   SREBP-1b   E47   SREBP-1a   HSF2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCCIP promoter sequence
   Search SABiosciences Chromatin IP Primers for BCCIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCCIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.1   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26.2

BCCIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCCIP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P127502:  view genomic region     (about GC identifiers)

Start:
127,512,104 bp from pter      End:
127,542,264 bp from pter
Size:
30,161 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287 (See protein sequence)
Recommended Name: BRCA2 and CDKN1A-interacting protein  
Size: 314 amino acids; 35979 Da
Subunit: Interacts with BRCA2, CDKN1A and MTDH/LYRIC
Subcellular location: Nucleus. Note=Colocalizes with BRCA2 in discrete nuclear foci
Developmental stage: Isoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis and
peaks in the G1/S phase of the cell cycle
Miscellaneous: HT1080 cells that constitutively express low levels of BCCIP display increased levels of spontaneous
single-stranded DNA and double-strand breaks
Secondary accessions: B3KP45 Q8ND15 Q96GC4 Q9P288
Alternative splicing: 4 isoforms:  Q9P287-1   Q9P287-2   Q9P287-3   Q9P287-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCCIP: NX_Q9P287

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P287

  • BCCIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_057651.1  NP_510868.1  NP_510869.1  

    ENSEMBL proteins: 
     ENSP00000278100   ENSP00000299130   ENSP00000357748   ENSP00000394758  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: BCCIP
    OriGene Protein Over-expression Lysate (see all 3): BCCIP
    OriGene Custom Protein Services for BCCIP 
    GenScript Custom Purified and Recombinant Proteins Services for BCCIP
    Novus Biologicals BCCIP Proteins
    Novus Biologicals BCCIP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BCCIP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10878006
    GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex IDA10878006


    BCCIP for ontologies           About GeneDecksing



    BCCIP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: BCCIP
    OriGene Custom Antibody Services for BCCIP 
    GenScript Custom Superior Antibodies Services for BCCIP
    Novus Biologicals BCCIP Antibodies
    Abcam antibodies for BCCIP 
    Uscn Antibodies for BCCIP
    ThermoFisher Antibodies for BCCIP

    Assay Products for BCCIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCCIP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BCCIP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BCCIP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR025602 BCP1_family

    Graphical View of Domain Structure for InterPro Entry Q9P287

    ProtoNet protein and cluster: Q9P287

    UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287
    Similarity: Belongs to the BCP1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287
    Function: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for
    repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end
    joining (NHEJ)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): BCCIP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCCIP
    1 QIAGEN miScript miRNA Assays for microRNA that regulate BCCIP:
    hsa-miR-3674
    SwitchGear 3'UTR luciferase reporter plasmidBCCIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCCIP (see all 7)
    OriGene shRNA RFP: BCCIP
    OriGene siRNA: BCCIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCCIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCCIP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCCIP (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCCIP (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): BCCIP (NM_078468)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCCIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCCIP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCCIP
    Search LifeMap BioReagents cell lines for BCCIP

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCCIP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18440304
    GO:0019207kinase regulator activity IDA10878006


    BCCIP for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for BCCIP:
     Decreased viability of wild-ty  Increased G1 DNA content  Increased cell number in S and 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCCIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for BCCIP (Q9P2872, 3 ENSP000003577484) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN2Q9NZM32, 3MINT-65663 I2D: score=5 
    PTNP212462, 3MINT-65674 I2D: score=5 
    CSNK2BP678702, 3MINT-8253044 I2D: score=2 
    RPL23P628292, 3, ENSP000003778654MINT-67606 I2D: score=10 STRING: ENSP00000377865
    HIST2H2BEQ167782, 3, ENSP000003581514MINT-66501 I2D: score=1 STRING: ENSP00000358151
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity IDA10878006
    GO:0006281DNA repair IEA--
    GO:0007049cell cycle IEA--
    GO:0061101neuroendocrine cell differentiation IDA18440304


    BCCIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCCIP
    Search CenterWatch for drugs/clinical trials and news about BCCIP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCCIP gene (3 alternative transcripts): 
    NM_016567.3  NM_078468.2  NM_078469.2  

    Unigene Cluster for BCCIP:

    BRCA2 and CDKN1A interacting protein
    Hs.715543  [show with all ESTs]
    Unigene Representative Sequence: NM_078469
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278100(uc021qar.1 uc001ljb.4) ENST00000299130(uc001ljc.4 uc010quj.2)
    ENST00000368759(uc001ljd.4) ENST00000463330 ENST00000478798 ENST00000429863


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): BCCIP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCCIP
    1 QIAGEN miScript miRNA Assays for microRNA that regulate BCCIP:
    hsa-miR-3674
    SwitchGear 3'UTR luciferase reporter plasmidBCCIP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCCIP (see all 7)
    OriGene shRNA RFP: BCCIP
    OriGene siRNA: BCCIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCCIP
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCCIP (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCCIP (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): BCCIP (NM_078468)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCCIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCCIP 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCCIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCCIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCCIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCCIP

    Additional cDNA sequence: 

    AB040450.1 AB040451.1 AK055691.1 AK300767.1 AK304529.1 AL834458.1 AY064248.1 AY064249.1 
    BC009771.1 

    20 DOTS entries:

    DT.92466941  DT.95322273  DT.100818738  DT.218804  DT.450133  DT.100038056  DT.97860228  DT.40133356 
    DT.121252144  DT.75123246  DT.121252159  DT.91688936  DT.100038057  DT.100709837  DT.100818746  DT.121252122 
    DT.121252180  DT.92466949  DT.95370204  DT.40285454 

    24/393 AceView cDNA sequences (see all 393):

    AA029422 CD557434 BM699098 BE465727 AW007523 AI554170 BQ013028 BF592156 
    AI040647 BM716747 BQ011998 BU726160 BM919929 AW591510 AI023292 AI245228 
    CA422631 BM680270 BX956732 BE048851 BM794824 BM823204 AW129088 BM974496 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BCCIP (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                    -                                                   
    SP2:              -     -                                                   
    SP3:                    -                 -     -     -                     
    SP4:                    -                 -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for BCCIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCCIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTCGTAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See BCCIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCCIP

    SOURCE GeneReport for Unigene cluster: Hs.715543

    UniProtKB/Swiss-Prot: BCCIP_HUMAN, Q9P287
    Tissue specificity: Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney,
    liver, lung, ovary, pancreas, placenta, and spleen

        SABiosciences Expression via Pathway-Focused PCR Array including BCCIP: 
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCCIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCCIP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCCIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCCIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCCIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BCCIP gene from 10/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bccip1 , 5 BRCA2 and CDKN1A interacting protein1, 5 84.08(n)1
    79.3(a)1
      7 (77.30 cM)5
    661651  NM_025392.21  NP_079668.21 
     1337093335 
    chicken
    (Gallus gallus)
    Aves BCCIP1 BRCA2 and CDKN1A interacting protein 72.54(n)
    71.76(a)
      426225  XM_423888.3  XP_423888.1 
    lizard
    (Anolis carolinensis)
    Reptilia BCCIP6
    --
    58(a)
    1 ↔ 1
    3(63048860-63060695)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61572 Xenopus laevis transcribed sequence with moderate similarity more 75.8(n)    CD325208.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bccip1 BRCA2 and CDKN1A interacting protein 62.13(n)
    56.48(a)
      541348  NM_001013475.2  NP_001013493.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92861 CG9286 47.46(n)
    36.23(a)
      41690  NM_142060.3  NP_650317.3 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1127.46
    Protein BCCIP homolog
    15(a)
    1 ↔ 1
    II(7053903-7055166)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BCP11 Bcp1p 46.42(n)
    30.37(a)
      851963   NP_010648.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G445101 protein BCCIP-like protein 47.28(n)
    30.4(a)
      819058  NM_130014.3  NP_566018.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08539001 hypothetical protein 41.7(n)
    25.44(a)
      4334821  NM_001058468.1  NP_001051933.1 


    ENSEMBL Gene Tree for BCCIP (if available)
    TreeFam Gene Tree for BCCIP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/188 NCBI SNPs in BCCIP are shown (see all 188    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733812181,2
    C,--121206578(+) TAGTGT/CCGTAA 3 -- int12Minor allele frequency- C:0.04WA 120
    rs1136871311,2
    C,--121206636(+) AGCTCA/GGTGGG 3 -- int12Minor allele frequency- G:0.04WA 120
    rs1176079541,2
    C,F,--121207013(+) ATCCAT/CTNNNN 3 -- int11Minor allele frequency- C:0.02EA 120
    rs2017153391,2
    C--121207873(-) AGAGAA/CCNNNN 3 -- int10--------
    rs79018521,2
    C,F,H,--121210287(+) CAACTC/TTACTC 3 -- int110Minor allele frequency- T:0.04EA NS NA WA 1242
    rs795425091,2
    --121210367(+) CAGCTC/GTAGCT 3 -- int10--------
    rs2014670251,2
    C--121211011(-) GCTTTC/TCNNNN 3 -- int10--------
    rs787791181,2
    --121211026(+) GAGGAC/TGGTTG 3 -- int12Minor allele frequency- T:0.07CSA WA 120
    rs74784861,2
    C,H--121211726(+) AAACAA/TTTCCA 6 N I mis14Minor allele frequency- T:0.00NS EA 406
    rs171536101,2
    H--121211788(-) AAATTC/GTTCCT 6 Q E mis1 trp37Minor allele frequency- G:0.00EU NS EA NA 482

    HapMap Linkage Disequilibrium report for BCCIP (127512104 - 127542264 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for BCCIP
         3 CNVs: 31780 31779 3825
         5 Indels: 85512 75409 43724 85513 75410

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCCIP
    DNA2.0 Custom Variant and Variant Library Synthesis for BCCIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BCCIP for disorders           About GeneDecksing

    OMIM gene information: 611883    OMIM disorders: --

    14 diseases for BCCIP:    About MalaCards
    sporadic breast cancer    basal cell carcinoma    breast-ovarian cancer    familial breast cancer
    breast cancer    ovarian cancer    brain cancer    conjunctivitis
    cervical cancer    cervicitis    astrocytoma    glioblastoma
    carcinoma    prostatitis

    2 Novoseek disease relationships for BCCIP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 23.7 7 11313963 (2), 12527204 (1), 19653894 (1)
    tumors 11.2 7 19653894 (3), 12527204 (2), 11313963 (1)

    Human Genome Epidemiology (HuGE) Navigator: BCCIP (3 documents)

    Export disorders for BCCIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCCIP gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with BCCIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. (PubMed id 11313963)1, 2, 3, 9 Liu J.... Shen Z. (2001)
    2. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. (PubMed id 10878006)1, 2, 3 Ono T....Ariga H. (2000)
    3. Genomic structure of the human BCCIP gene and its expression in cancer. (PubMed id 12527204)1, 2, 9 Meng X.... Shen Z. (2003)
    4. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. (PubMed id 15539944)1, 2, 9 Meng X.... Shen Z. (2004)
    5. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. (PubMed id 15713648)1, 2, 9 Lu H....Shen Z. (2005)
    6. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. (PubMed id 18440304)1, 2 Ash S.C....Britt D.E. (2008)
    7. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. (PubMed id 17947333)1, 2 Lu H....Shen Z. (2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Inhibition of G1 to S cell cycle progression by BCCIP beta. (PubMed id 14726710)1, 2 Meng X.... Shen Z. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56647 HGNC: 978 AceView: BCCIP Ensembl:ENSG00000107949 euGenes: HUgn56647
    ECgene: BCCIP H-InvDB: BCCIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCCIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCCIP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCCIP gene:
    Search GeneIP for patents involving BCCIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for BCCIP   OriGene shRNA RFP for BCCIP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCCIP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCCIP  
     OriGene Protein Over-expression Lysate for BCCIP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BCCIP   OriGene 3'-UTR Clone for BCCIP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCCIP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCCIP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for BCCIP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCCIP   OriGene Custom Protein Services for BCCIP  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCCIP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCCIP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCCIP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCCIP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCCIP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCCIP
     GenScript Custom Purified and Recombinant Proteins Services for BCCIP GenScript cDNA clones with any tag delivered in your preferred vector for BCCIP
     GenScript Custom Assay Services for BCCIP GenScript Custom Superior Antibodies Services for BCCIP
     GenScript Custom overexpressing Cell Line Services for BCCIP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BCCIP promoter
     Search Chromatin IP Primers for BCCIP
     RT2 qPCR Primer Assay in human, mouse, rat BCCIP
     GNC Network for BCCIP
     SABiosciences PCR Arrays including human, mouse, rat BCCIP
     Search Tocris compounds for BCCIP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BCCIP antibodies
     BCCIP proteins
     BCCIP lysates
     Antibodies for BCCIP
     See all of Abcam's Antibodies, Kits and Proteins for BCCIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     BCCIP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for BCCIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCCIP
     SwitchGear 3'UTR luciferase reporter plasmids for BCCIP
     SwitchGear Promoter luciferase reporter plasmids for BCCIP
     ThermoFisher Antibodies for BCCIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCCIP
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCCIP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4