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Aliases for BCCIP Gene

Aliases for BCCIP Gene

  • BRCA2 And CDKN1A Interacting Protein 2 3 5
  • BRCA2 And CDKN1A-Interacting Protein 2 3
  • P21- And CDK-Associated Protein 1 3 4
  • Protein TOK-1 3 4
  • TOK1 3 4
  • BRCA2 And Cip1/P21 Interacting Protein 3
  • Cdk Inhibitor P21 Binding Protein 3
  • BCCIPalpha 3
  • TOK-1alpha 3
  • BCCIPbeta 3
  • TOK-1beta 3
  • TOK-1 3

External Ids for BCCIP Gene

Previous GeneCards Identifiers for BCCIP Gene

  • GC10P126487
  • GC10P126715
  • GC10P127553
  • GC10P127086
  • GC10P127502
  • GC10P121201

Summaries for BCCIP Gene

Entrez Gene Summary for BCCIP Gene

  • This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCCIP Gene

BCCIP (BRCA2 And CDKN1A Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and kinase regulator activity.

UniProtKB/Swiss-Prot for BCCIP Gene

  • May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

Gene Wiki entry for BCCIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCCIP Gene

Genomics for BCCIP Gene

Regulatory Elements for BCCIP Gene

Enhancers for BCCIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F125868 0.7 ENCODE 10.9 +45.0 45032 0.2 SCRT1 CTCF ZNF654 PKNOX1 FOXA3 MIER2 REST RAD21 ZNF664 GATA3 RNU2-42P FANK1 BCCIP UROS ENSG00000277371
GH10F125798 0.7 ENCODE 10.7 -25.4 -25409 0.2 SOX13 GATAD2A ELF3 SOX5 HMG20B NFIA TEAD1 ZNF511 HMG20A RAD21 EDRF1 BCCIP UROS MMP21 MIR4484
GH10F125844 0.5 ENCODE 11 +22.0 21973 1.5 NFIL3 CEBPA HLF BCCIP UROS ENSG00000277371
GH10F125850 0.4 ENCODE 11.1 +27.6 27646 1.4 SCRT1 SCRT2 UROS BCCIP EDRF1 MMP21 ENSG00000277371
GH10F125843 0.4 ENCODE 11 +20.5 20518 0.8 MNT UROS BCCIP EDRF1 ENSG00000234134 FLJ37035 ENSG00000277371
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCCIP on UCSC Golden Path with GeneCards custom track

Promoters for BCCIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001428227 -35 2601 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for BCCIP Gene

125,823,535 bp from pter
125,853,695 bp from pter
30,161 bases
Plus strand

Genomic View for BCCIP Gene

Genes around BCCIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCCIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCCIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCCIP Gene

Proteins for BCCIP Gene

  • Protein details for BCCIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRCA2 and CDKN1A-interacting protein
    Protein Accession:
    Secondary Accessions:
    • B3KP45
    • Q8ND15
    • Q96GC4
    • Q9P288

    Protein attributes for BCCIP Gene

    314 amino acids
    Molecular mass:
    35979 Da
    Quaternary structure:
    • Interacts with BRCA2, CDKN1A and MTDH/LYRIC.
    • HT1080 cells that constitutively express low levels of BCCIP display increased levels of spontaneous single-stranded DNA and double-strand breaks.

    Alternative splice isoforms for BCCIP Gene


neXtProt entry for BCCIP Gene

Post-translational modifications for BCCIP Gene

  • Ubiquitination at Lys 76, Lys 84, Lys 137, Lys 174, and Lys 201
  • Modification sites at PhosphoSitePlus

Other Protein References for BCCIP Gene

No data available for DME Specific Peptides for BCCIP Gene

Domains & Families for BCCIP Gene

Protein Domains for BCCIP Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BCP1 family.
  • Belongs to the BCP1 family.
genes like me logo Genes that share domains with BCCIP: view

No data available for Gene Families for BCCIP Gene

Function for BCCIP Gene

Molecular function for BCCIP Gene

UniProtKB/Swiss-Prot Function:
May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

Gene Ontology (GO) - Molecular Function for BCCIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019207 kinase regulator activity IDA 10878006
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BCCIP: view
genes like me logo Genes that share phenotypes with BCCIP: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCCIP Gene

Localization for BCCIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCCIP Gene

Nucleus. Note=Colocalizes with BRCA2 in discrete nuclear foci.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCCIP gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for BCCIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10878006
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex IDA 10878006
genes like me logo Genes that share ontologies with BCCIP: view

Pathways & Interactions for BCCIP Gene

SuperPathways for BCCIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCCIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IDA 10878006
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0061101 neuroendocrine cell differentiation IDA 18440304
genes like me logo Genes that share ontologies with BCCIP: view

No data available for Pathways by source and SIGNOR curated interactions for BCCIP Gene

Transcripts for BCCIP Gene

Unigene Clusters for BCCIP Gene

BRCA2 and CDKN1A interacting protein:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCCIP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for BCCIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCCIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCCIP Gene

Protein differential expression in normal tissues from HIPED for BCCIP Gene

This gene is overexpressed in Salivary gland (6.8) and Liver (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCCIP Gene

Protein tissue co-expression partners for BCCIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCCIP Gene:


SOURCE GeneReport for Unigene cluster for BCCIP Gene:


mRNA Expression by UniProt/SwissProt for BCCIP Gene:

Tissue specificity: Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
genes like me logo Genes that share expression patterns with BCCIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCCIP Gene

Orthologs for BCCIP Gene

This gene was present in the common ancestor of animals.

Orthologs for BCCIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCCIP 34 35
  • 99.58 (n)
(Bos Taurus)
Mammalia BCCIP 34 35
  • 88.72 (n)
(Mus musculus)
Mammalia Bccip 34 16 35
  • 85.73 (n)
(Rattus norvegicus)
Mammalia Bccip 34
  • 84.7 (n)
(Canis familiaris)
Mammalia BCCIP 34 35
  • 83.76 (n)
(Monodelphis domestica)
Mammalia BCCIP 35
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia BCCIP 35
  • 50 (a)
(Gallus gallus)
Aves BCCIP 34 35
  • 76.43 (n)
(Anolis carolinensis)
Reptilia BCCIP 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bccip 34
  • 71.61 (n)
Str.157 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6157 34
(Danio rerio)
Actinopterygii bccip 34 35
  • 63.12 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9378 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003476 34
  • 48.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9286 34 35
  • 46.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5244 35
  • 32 (a)
Species where no ortholog for BCCIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCCIP Gene

Gene Tree for BCCIP (if available)
Gene Tree for BCCIP (if available)

Paralogs for BCCIP Gene

No data available for Paralogs for BCCIP Gene

Variants for BCCIP Gene

Sequence variations from dbSNP and Humsavar for BCCIP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs4385801 Pathogenic 125,823,221(+) GGGTC(G/T)CGTGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs869320669 Pathogenic 125,823,225(-) CCACC(A/C)ACGCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs869320670 Pathogenic 125,823,205(-) TGAGG(C/T)GCGGG nc-transcript-variant, upstream-variant-2KB, splice-donor-variant, utr-variant-5-prime
rs10159992 -- 125,826,500(+) TTCTT(C/T)ACAGA intron-variant
rs10794027 -- 125,847,993(+) CCCAT(C/T)ACTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCCIP Gene

Variant ID Type Subtype PubMed ID
nsv8737 CNV loss 18304495
nsv8736 CNV loss 18304495
nsv428241 CNV loss 18775914
nsv1111042 CNV tandem duplication 24896259
esv4748 OTHER sequence alteration 18987735
esv3396538 CNV duplication 20981092
esv2759788 CNV gain 17122850
dgv520e59 CNV tandem duplication 20981092

Variation tolerance for BCCIP Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCCIP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCCIP Gene

Disorders for BCCIP Gene

Relevant External Links for BCCIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BCCIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCCIP Gene

Publications for BCCIP Gene

  1. Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. (PMID: 11313963) Liu J. … Shen Z. (Oncogene 2001) 2 3 4 22 64
  2. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. (PMID: 15713648) Lu H. … Shen Z. (Mol. Cell. Biol. 2005) 3 4 22 64
  3. BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1. (PMID: 15539944) Meng X. … Shen Z. (Cell Cycle 2004) 3 4 22 64
  4. Genomic structure of the human BCCIP gene and its expression in cancer. (PMID: 12527204) Meng X. … Shen Z. (Gene 2003) 3 4 22 64
  5. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. (PMID: 10878006) Ono T. … Ariga H. (J. Biol. Chem. 2000) 2 3 4 64

Products for BCCIP Gene

Sources for BCCIP Gene

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