BCAS4 Gene
protein-coding GIFtS: 48
GCID: GC20P049411
|
|
breast carcinoma amplified sequence 4
| |
Aliases
for BCAS4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Breast Carcinoma Amplified Sequence 41 2 | | CNOL1 2 | | FLJ204951 | | BCAS4/BCAS3 Fusion2 | | Breast Carcinoma Amplified Sequence 4/3 Fusion Protein2 | | Breast Carcinoma-Amplified Sequence 42 |
Export aliases for BCAS4 gene to outside databasesPrevious GC identifers: GC20P049139 GC20P050049 GC20P050096 GC20P048844 GC20P046159 |
Summaries
for BCAS4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for BCAS4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BCAS4 gene promoter:
AhR Egr-2 Egr-3 CP2 Egr-1 Egr-4 Arnt GATA-1 Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for BCAS4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAS4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13BCAS4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P049411: view genomic region
(about GC identifiers)
Start:
|
49,411,431 bp from pter |
End:
|
49,493,714 bp from pter |
Size:
|
82,284 bases |
Orientation:
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plus strand |
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Proteins
for BCAS4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BCAS4_HUMAN, Q8TDM0 (See
protein sequence)Recommended Name: Breast carcinoma-amplified sequence 4 Size: 211 amino acids; 22758 Da
Subcellular location: Cytoplasm (Potential)
Sequence caution: Sequence=AAH38381.1; Type=Erroneous initiation; Sequence=BAA91209.1; Type=Erroneous initiation;Sequence=CAD53579.1; Type=Erroneous initiation;
Secondary accessions: Q5TD52 Q5TD53 Q5TD54 Q5U5K7 Q5XKE8 Q8IXI7 Q8NEZ6 Q8TDL9 Q9NX13 Q9Y511Alternative splicing: 3 isoforms: Q8TDM0-1 Q8TDM0-2 Q8TDM0-3 Explore the universe of human proteins at neXtProt for BCAS4: NX_Q8TDM0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TDM0
BCAS4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001010974.1 NP_060313.3 NP_942094.2
ENSEMBL proteins: ENSP00000351642 ENSP00000360669 ENSP00000392594 ENSP00000418559 ENSP00000262591
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
BCAS4 for ontologies About GeneDecksing
BCAS4 Antibody Products:
Assay Products for BCAS4: |
Protein
Domains /
Families
for BCAS4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BCAS4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TDM0ProtoNet protein and cluster: Q8TDM0 UniProtKB/Swiss-Prot: BCAS4_HUMAN, Q8TDM0Similarity: Belongs to the cappuccino family |
Function
for BCAS4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCAS4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCAS4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): BCAS4 (NM_017843) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCAS4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAS4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAS4 |
|
Pathways & Interactions
for BCAS4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BCAS4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for BCAS4 (ENSP000003516424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for BCAS4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BCAS4
Search CenterWatch for drugs/clinical trials and news about BCAS4
|
Transcripts
for BCAS4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BCAS4 gene (3 alternative transcripts): NM_001010974.1 NM_017843.3 NM_198799.2 Unigene Cluster for BCAS4: Breast carcinoma amplified sequence 4 Hs.381178 [show with all ESTs]Unigene Representative Sequence: BC0568836 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358791(uc002xvq.3 uc002xvr.3 uc002xvs.3) ENST00000371608
ENST00000445038 ENST00000463943(uc002xvp.1) ENST00000485049 ENST00000262591
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCAS4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCAS4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): BCAS4 (NM_017843) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BCAS4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAS4 |
Additional cDNA sequence: AF361220.1 AJ511266.1 AK000502.1 BC038381.1 BC047337.1 BC056883.1 BC112282.1 8 DOTS entries: DT.101963309 DT.92422553 DT.101987255 DT.97805997 DT.100776563 DT.100741255 DT.120805494 DT.91981905 1 AceView cDNA sequence: BK000274
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BCAS4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for BCAS4
|
Expression
for BCAS4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BCAS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCTTCTCT
About this image
See BCAS4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCAS4
SOURCE GeneReport for Unigene cluster: Hs.381178
UniProtKB/Swiss-Prot: BCAS4_HUMAN, Q8TDM0Tissue specificity: Brain, thymus, spleen, kidney and placenta. Overexpressed in most breast cancer cell lines
SABiosciences Custom PCR Arrays for BCAS4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCAS4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BCAS4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAS4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAS4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAS4 |
Orthologs
for BCAS4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BCAS4 gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
BCAS46 |
-- |
54(a) |
1 ↔ 1 |
GL343226.1(2125042-2131514) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.181592 |
Xenopus laevis transcribed sequence with weak similarity more |
73.82(n) |
|
BX850540.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
blos46 |
BLOC-1 subunit 4 |
19(a) |
1 → many |
3L(10872185-10873288) |
ENSEMBL Gene Tree for BCAS4 (if available)
TreeFam Gene Tree for BCAS4 (if available) |
Paralogs
for BCAS4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BCAS4 gene
- BLOC1S42
2 SIMAP similar genes for BCAS4 using alignment to 4 protein entries: BCAS4_HUMAN (see all proteins):COQ5 BLOC1S4
BCAS4 for paralogs About GeneDecksing
|
Genomic Variants
for BCAS4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BCAS4 (49411431 - 49493714 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BCAS4
1 CNV: 5141 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCAS4 |
|
Disorders
/ Diseases
for BCAS4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BCAS4 for disorders About GeneDecksing
OMIM gene information: 607471
OMIM disorders: --
UniProtKB/Swiss-Prot: BCAS4_HUMAN, Q8TDM0
Note=A chromosomal aberration involving BCAS4 has been found in some breast carcinoma cell lines.Translocation t(17;20)(q23;q13) with BCAS3
5  diseases for BCAS4: About MalaCardsbreast carcinoma fallopian tube carcinoma carcinoma choanal atresia
breast cancer
2 diseases from the University of Copenhagen DISEASES database for BCAS4:Choanal atresia Fallopian tube carcinoma Export disorders for BCAS4 gene to outside databases
|
Publications
for BCAS4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BCAS4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BCAS4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. (PubMed id 12378525)1, 2, 3, 9 Baerlund M.... Kallioniemi A. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for BCAS4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BCAS4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BCAS4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BCAS4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BCAS4 gene:
Search GeneIP for patents involving BCAS4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BCAS4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BCAS4 | | OriGene shRNA RFP for BCAS4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCAS4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCAS4 | | | OriGene Protein Over-expression Lysate for BCAS4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BCAS4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCAS4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCAS4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BCAS4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BCAS4 | | OriGene Custom Protein Services for BCAS4 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCAS4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCAS4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAS4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCAS4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAS4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAS4 |
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 |  |  |  | |
| | | | Search Tocris compounds for BCAS4 |
| |  |  |  |  | | | | |
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 | | | BCAS4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAS4 |
|  |  |  | | | | ThermoFisher Antibody for BCAS4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAS4 |
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