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Aliases for BCAS4 Gene

Aliases for BCAS4 Gene

  • Breast Carcinoma Amplified Sequence 4 2 3
  • Breast Carcinoma Amplified Sequence 4/3 Fusion Protein 3
  • Breast Carcinoma-Amplified Sequence 4 3
  • BCAS4/BCAS3 Fusion 3
  • CNOL 3

External Ids for BCAS4 Gene

Previous GeneCards Identifiers for BCAS4 Gene

  • GC20P049139
  • GC20P050049
  • GC20P050096
  • GC20P048844
  • GC20P049411
  • GC20P046159

Summaries for BCAS4 Gene

GeneCards Summary for BCAS4 Gene

BCAS4 (Breast Carcinoma Amplified Sequence 4) is a Protein Coding gene. Diseases associated with BCAS4 include choanal atresia. An important paralog of this gene is BLOC1S4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAS4 Gene

Genomics for BCAS4 Gene

Regulatory Elements for BCAS4 Gene

Genomic Location for BCAS4 Gene

Start:
50,794,894 bp from pter
End:
50,882,676 bp from pter
Size:
87,783 bases
Orientation:
Plus strand

Genomic View for BCAS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAS4 Gene

Proteins for BCAS4 Gene

  • Protein details for BCAS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDM0-BCAS4_HUMAN
    Recommended name:
    Breast carcinoma-amplified sequence 4
    Protein Accession:
    Q8TDM0
    Secondary Accessions:
    • Q5TD52
    • Q5TD53
    • Q5TD54
    • Q5U5K7
    • Q5XKE8
    • Q8IXI7
    • Q8NEZ6
    • Q8TDL9
    • Q9NX13
    • Q9Y511

    Protein attributes for BCAS4 Gene

    Size:
    211 amino acids
    Molecular mass:
    22758 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH38381.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91209.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD53579.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BCAS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAS4 Gene

Proteomics data for BCAS4 Gene at MOPED

Post-translational modifications for BCAS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCAS4 Gene

Antibody Products

No data available for DME Specific Peptides for BCAS4 Gene

Domains for BCAS4 Gene

Protein Domains for BCAS4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCAS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDM0

UniProtKB/Swiss-Prot:

BCAS4_HUMAN :
  • Q8TDM0
Family:
  • Belongs to the cappuccino family.
genes like me logo Genes that share domains with BCAS4: view

No data available for Gene Families for BCAS4 Gene

Function for BCAS4 Gene

Animal Model Products

CRISPR Products

miRNA for BCAS4 Gene

miRTarBase miRNAs that target BCAS4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCAS4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BCAS4 Gene

Localization for BCAS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAS4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAS4 Gene COMPARTMENTS Subcellular localization image for BCAS4 gene
Compartment Confidence
mitochondrion 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BCAS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BCAS4: view

Pathways for BCAS4 Gene

SuperPathways for BCAS4 Gene

No Data Available

Interacting Proteins for BCAS4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351642%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000351642 for BCAS4 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for BCAS4 Gene

None

No data available for Pathways by source for BCAS4 Gene

Transcripts for BCAS4 Gene

mRNA/cDNA for BCAS4 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BCAS4 Gene

Breast carcinoma amplified sequence 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCAS4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAS4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: - -

Relevant External Links for BCAS4 Gene

GeneLoc Exon Structure for
BCAS4
ECgene alternative splicing isoforms for
BCAS4

Expression for BCAS4 Gene

mRNA expression in normal human tissues for BCAS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BCAS4 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCAS4 Gene

SOURCE GeneReport for Unigene cluster for BCAS4 Gene Hs.381178

mRNA Expression by UniProt/SwissProt for BCAS4 Gene

Q8TDM0-BCAS4_HUMAN
Tissue specificity: Brain, thymus, spleen, kidney and placenta. Overexpressed in most breast cancer cell lines.
genes like me logo Genes that share expressions with BCAS4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BCAS4 Gene

Orthologs for BCAS4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCAS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BCAS4 35
  • 85.8 (n)
  • 82.1 (a)
BCAS4 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCAS4 35
  • 84.11 (n)
  • 80.73 (a)
BCAS4 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCAS4 35
  • 99.67 (n)
  • 99.51 (a)
BCAS4 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCAS4 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCAS4 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCAS4 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490358 35
  • 56.62 (n)
  • 48.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18159 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for BCAS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCAS4 Gene

ENSEMBL:
Gene Tree for BCAS4 (if available)
TreeFam:
Gene Tree for BCAS4 (if available)

Paralogs for BCAS4 Gene

Paralogs for BCAS4 Gene

Selected SIMAP similar genes for BCAS4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BCAS4: view

Variants for BCAS4 Gene

Sequence variations from dbSNP and Humsavar for BCAS4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs6702 -- 50,877,072(+) CACGG(A/G)GTGTG utr-variant-3-prime
rs11641 -- 50,876,981(-) AGCCC(C/T)GGCCA utr-variant-3-prime
rs734333 -- 50,806,119(-) CACCT(C/T)CATTT intron-variant
rs761034 -- 50,806,064(-) CATGC(A/G)GGTAA intron-variant
rs761035 -- 50,805,901(-) CTCCC(A/G)GGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCAS4 Gene

Variant ID Type Subtype PubMed ID
nsv834001 CNV Loss 17160897
nsv834002 CNV Loss 17160897
nsv513548 CNV Insertion 21212237
nsv518896 CNV Loss 19592680
esv2722504 CNV Deletion 23290073
esv996532 CNV Insertion 20482838
esv1413515 CNV Insertion 17803354

Relevant External Links for BCAS4 Gene

HapMap Linkage Disequilibrium report
BCAS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAS4 Gene

Disorders for BCAS4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BCAS4 Gene in MalaCards »

(1) Diseases for BCAS4 Gene including...

UniProtKB/Swiss-Prot

BCAS4_HUMAN
  • Note=A chromosomal aberration involving BCAS4 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS3.

(2) University of Copenhagen DISEASES for BCAS4 Gene

Relevant External Links for BCAS4

Genetic Association Database (GAD)
BCAS4
genes like me logo Genes that share disorders with BCAS4: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for BCAS4 Gene

Publications for BCAS4 Gene

  1. Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. (PMID: 12378525) Baerlund M. … Kallioniemi A. (Genes Chromosomes Cancer 2002) 2 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for BCAS4 Gene

Sources for BCAS4 Gene

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