Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BCAS3 Gene

protein-coding   GIFtS: 50
GCID: GC17P058755

Breast Carcinoma Amplified Sequence 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Breast Carcinoma Amplified Sequence 31 2     Breast Carcinoma Amplified Sequence 4/3 Fusion Protein2
GAOB12 3     Breast Carcinoma-Amplified Sequence 32
MAAB2     Metastasis Associated Antigen Of Breast Cancer2
BCAS4/BCAS3 Fusion2     Protein Maab12

External Ids:    HGNC: 143471   Entrez Gene: 548282   Ensembl: ENSG000001413767   OMIM: 6074705   UniProtKB: Q9H6U63   

Export aliases for BCAS3 gene to outside databases

Previous GC identifers: GC17P058649 GC17P061310 GC17P059097 GC17P059229 GC17P056109 GC17P054125


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for BCAS3 Gene:
BCAS3 (breast carcinoma amplified sequence 3) is a protein-coding gene. Diseases associated with BCAS3 include breast cancer, and smallpox.

Gene Wiki entry for BCAS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCAS3 gene promoter:
         SRF   TBP   AhR   SRF (504 AA)   MyoD   Arnt   Nkx6-1   TFIID   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBCAS3 promoter sequence
   Search Chromatin IP Primers for BCAS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.2

BCAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAS3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P058755:  view genomic region     (about GC identifiers)

Start:
58,754,814 bp from pter      End:
59,470,199 bp from pter
Size:
715,386 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BCAS3_HUMAN, Q9H6U6 (See protein sequence)
Recommended Name: Breast carcinoma-amplified sequence 3  
Size: 928 amino acids; 101237 Da
Developmental stage: Fetal
Sequence caution: Sequence=AAF70324.1; Type=Frameshift; Positions=693; Sequence=AAL99634.1; Type=Erroneous
initiation; Sequence=BAA90966.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14078.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q17RM0 Q6KF21 Q8IXI6 Q8NDR8 Q8TDL9 Q8TDM1 Q8WY55 Q9BVF0 Q9H957 Q9H9Y9
Q9NXP4
Alternative splicing: 6 isoforms:  Q9H6U6-1   Q9H6U6-2   Q9H6U6-3   Q9H6U6-8   Q9H6U6-7   Q9H6U6-6   (No experimental confirmation available. Ref.2 (AK225757) sequence differs from that shown due to a frameshift in position 895. Ref.4 (CAD54076) sequence differs from that shown due to a frameshift in position 894. Ref.4 (CAD54076) sequence is in conflict in position: 891:G->R)

Explore the universe of human proteins at neXtProt for BCAS3: NX_Q9H6U6

Explore proteomics data for BCAS3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BCAS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092902.1  NP_060149.3  

    ENSEMBL proteins: 
     ENSP00000465328   ENSP00000466075   ENSP00000466078   ENSP00000385323   ENSP00000465441  
     ENSP00000467743   ENSP00000375067   ENSP00000464864   ENSP00000468592   ENSP00000386173  
     ENSP00000465539   ENSP00000468682   ENSP00000464825   ENSP00000465175   ENSP00000466552  
     ENSP00000464711  

    BCAS3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCAS3
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for BCAS3
    OriGene Custom Protein Services for BCAS3
    GenScript Custom Purified and Recombinant Proteins Services for BCAS3
    Novus Biologicals BCAS3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCAS3

    BCAS3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for BCAS3
    OriGene Custom Antibody Services for BCAS3
    Novus Biologicals BCAS3 Antibodies
    Abcam antibodies for BCAS3
    Cloud-Clone Corp. Antibodies for BCAS3
    ThermoFisher Antibodies for BCAS3
    LSBio Antibodies in human, mouse, rat for BCAS3

    BCAS3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCAS3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCAS3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BCAS3
    Cloud-Clone Corp. CLIAs for BCAS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR022175 BCAS3
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H6U6

    ProtoNet protein and cluster: Q9H6U6

    UniProtKB/Swiss-Prot: BCAS3_HUMAN, Q9H6U6
    Similarity: Belongs to the WD repeat BCAS3 family
    Similarity: Contains 3 WD repeats


    BCAS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    BCAS3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCAS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCAS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCAS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCAS3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat BCAS3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate BCAS3:
    hsa-miR-100* hsa-miR-4271 hsa-miR-4325 hsa-miR-2110 hsa-miR-1236 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidBCAS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BCAS3
    Predesigned siRNA for gene silencing in human, mouse, rat BCAS3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCAS3

    Clone
    Products:
         
    OriGene clones in human, mouse for BCAS3 (see all 13)
    OriGene ORF clones in mouse, rat for BCAS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCAS3 (NM_017679)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAS3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCAS3
    Browse ESI BIO Cell Lines and PureStem Progenitors for BCAS3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BCAS3_HUMAN, Q9H6U6: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0071944cell periphery IEA--

    BCAS3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BCAS3
    Interactions:

        GeneGlobe Interaction Network for BCAS3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for BCAS3 (Q9H6U61, 3 ENSP000003750674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VIMP086701, ENSP000002242374EBI-6083685,EBI-353844 STRING: ENSP00000224237
    C16orf70Q9BSU13I2D: score=3 
    ATG2AQ2TAZ03I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCAS3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BCAS3 gene (2 alternative transcripts): 
    NM_001099432.1  NM_017679.3  

    Unigene Cluster for BCAS3:

    Breast carcinoma amplified sequence 3
    Hs.655028  [show with all ESTs]
    Unigene Representative Sequence: AK225757
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000588168 ENST00000591147 ENST00000589222 ENST00000591371 ENST00000593004
    ENST00000589916 ENST00000407086(uc010wow.1 uc002iyu.4 uc002iyw.4 uc002iyy.4 uc002iza.4 uc002izb.4 uc002izc.4)
    ENST00000588532 ENST00000592848 ENST00000390652(uc002iyv.4 uc002iyz.4)
    ENST00000592393 ENST00000586241 ENST00000588462 ENST00000408905(uc002iyx.1)
    ENST00000586705 ENST00000585744 ENST00000588874 ENST00000590128
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BCAS3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate BCAS3:
    hsa-miR-100* hsa-miR-4271 hsa-miR-4325 hsa-miR-2110 hsa-miR-1236 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidBCAS3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BCAS3
    Predesigned siRNA for gene silencing in human, mouse, rat BCAS3
    Clone
    Products:
         
    OriGene clones in human, mouse for BCAS3 (see all 13)
    OriGene ORF clones in mouse, rat for BCAS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCAS3 (NM_017679)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAS3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BCAS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAS3
      QuantiTect SYBR Green Assays in human, mouse, rat BCAS3
      QuantiFast Probe-based Assays in human, mouse, rat BCAS3

    Additional mRNA sequence: 

    AF260268.1 AF361219.1 AJ511332.1 AJ518105.1 AJ518836.1 AK000135.1 AK022526.1 AK023054.1 
    AK025510.1 AK125409.1 AK225757.1 AK304791.1 AK314744.1 AL831895.1 BC001250.1 BC013841.1 
    BC017390.1 BC029983.1 BC033220.1 BC036280.1 BC117275.1 BC143386.1 BC143387.1 

    Selected DOTS entries (see all 33):

    DT.100792919  DT.100792912  DT.100792917  DT.212862  DT.100792913  DT.100792918  DT.100009149  DT.100792914 
    DT.100792911  DT.100036799  DT.91749935  DT.101981914  DT.100792915  DT.101983053  DT.121005637  DT.101957445 
    DT.102843813  DT.121005900  DT.91749932  DT.100036796  DT.102843819  DT.121005855  DT.97861965  DT.101981913 

    Selected AceView cDNA sequences (see all 94):

    BM449676 BE891604 BI857060 BQ437432 AA972856 AI348422 BC036280 BU193878 
    BG281464 BU188871 BU160266 BQ716393 AI887771 CR610433 BE895915 BE390374 
    BU189345 CA444316 CA455392 BC029983 BG281311 BU943989 BU541048 AI749026 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BCAS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BCAS3 Expression
    About this image

    BCAS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCAS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655028

    UniProtKB/Swiss-Prot: BCAS3_HUMAN, Q9H6U6
    Tissue specificity: Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland,
    brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial
    cells. Overexpressed in most breast cancer cell lines

        Custom PCR Arrays for BCAS3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BCAS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAS3
    QuantiTect SYBR Green Assays in human, mouse, rat BCAS3
    QuantiFast Probe-based Assays in human, mouse, rat BCAS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for BCAS3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcas31 , 5 breast carcinoma amplified sequence 31, 5 89.08(n)1
    96.87(a)1
      11 (51.34 cM)5
    1921971  NM_138681.41  NP_619622.31 
     853531675 
    chicken
    (Gallus gallus)
    Aves BCAS31 breast carcinoma amplified sequence 3 82.72(n)
    94.16(a)
      417643  XM_415889.4  XP_415889.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    89(a)
    85(a)
    many → 1
    many → 1
    GL343393.1(535664-660499)
    GL343393.1(678516-773514)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bcas31 breast carcinoma amplified sequence 3 77.5(n)
    88.44(a)
      100487875  XM_004911624.1  XP_004911681.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637642 hypothetical protein MGC63764 77.23(n)   393594  BC056819.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG431541 CG43154 47.04(n)
    42.24(a)
      32136  NM_167309.3  NP_727567.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F56C9.106
    Protein F56C9.10, isoform a (F56C9.10) mRNA, compl...
    16(a)
    1 ↔ 1
    III(7329720-7335128) WBGene00018953


    ENSEMBL Gene Tree for BCAS3 (if available)
    TreeFam Gene Tree for BCAS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BCAS3 (see all 12469)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs603790941,2
    C,F--54122413(+) ATCACA/GCCCAG 2 -- us2k16Minor allele frequency- G:0.28WA CSA EA 245
    rs1814074151,2
    --58753209(+) CTTTTG/TGTGTT 2 -- us2k10--------
    rs1865807561,2
    --58753376(+) ACCCTC/TCTTTT 2 -- us2k10--------
    rs570692691,2
    C,F--58753556(+) TCATGC/GTAGGC 2 -- us2k11Minor allele frequency- G:0.16EA 120
    rs1451746911,2
    --58753611(+) CCCACA/TTTATC 2 -- us2k10--------
    rs1893964121,2
    --58753727(+) ACGATC/TTCGGC 2 -- us2k10--------
    rs65039861,2
    C,F,A--58753956(+) gtgccC/Tggcct 2 -- us2k13Minor allele frequency- T:0.33NA WA 6
    rs1394905901,2
    --58753961(+) CGGCCG/TTTTCT 2 -- us2k10--------
    rs2016739291,2
    --58753974(+) ATTTC-/TTTTTT 2 -- us2k10--------
    rs1810877051,2
    --58753981(+) TTTTTA/TAAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCAS3 (58754814 - 59004814 bp, first 250kb of BCAS3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BCAS3 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665893CNV Deletion23128226
    esv2664239CNV Deletion23128226
    esv2669101CNV Deletion23128226
    esv2663813CNV Deletion23128226
    esv2668879CNV Deletion23128226
    esv2669962CNV Deletion23128226
    esv2660744CNV Deletion23128226
    esv2676217CNV Deletion23128226
    nsv2112CNV Insertion18451855
    esv2581647CNV Insertion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCAS3
    DNA2.0 Custom Variant and Variant Library Synthesis for BCAS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607470    OMIM disorders: --

    UniProtKB/Swiss-Prot: BCAS3_HUMAN, Q9H6U6
  • Note=A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines.
    Translocation t(17;20)(q23;q13) with BCAS4

  • 14 diseases for BCAS3:    
    About MalaCards
    breast cancer    smallpox    rabies    kidney disease
    acute myeloid leukemia    myeloid leukemia    obesity    thyroiditis
    leukemia    alzheimer's disease    prostatitis    multiple myeloma
    myeloma    malaria

    1 disease from the University of Copenhagen DISEASES database for BCAS3:
    Rabies

    BCAS3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for BCAS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 61.9 11 12378525 (4), 10811121 (1), 14598882 (1), 18721486 (1) (see all 7)
    cancer 26.5 2 7780332 (1), 17646988 (1)
    tumors 25.3 6 7780332 (1), 15583840 (1), 17393302 (1), 12455056 (1) (see all 5)

    Genetic Association Database (GAD): BCAS3
    Human Genome Epidemiology (HuGE) Navigator: BCAS3 (2 documents)

    Export disorders for BCAS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BCAS3 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with BCAS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. (PubMed id 12378525)1, 2, 3, 9 Baerlund M.... Kallioniemi A. (Genes Chromosomes Cancer 2002)
    2. A genome-wide association study of optic disc parameters. (PubMed id 20548946)1, 4 Ramdas W.D....van Duijn C.M. (PLoS Genet. 2010)
    3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    4. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    9. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)
    10. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54828 HGNC: 14347 AceView: BCAS3.1 Ensembl:ENSG00000141376 euGenes: HUgn54828
    ECgene: BCAS3 H-InvDB: BCAS3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BCAS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCAS3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BCAS3 gene:
    Search GeneIP for patents involving BCAS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BCAS3   OriGene RNAi products in human, mouse, rat for BCAS3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for BCAS3   OriGene clones in human, mouse for BCAS3  
     OriGene qSTAR qPCR primer pairs in human, mouse for BCAS3   OriGene Purified Protein for BCAS3  
     OriGene ORF clones in mouse, rat for BCAS3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCAS3   OriGene Custom Protein Services for BCAS3  

     
     
     Block miRNA regulation of human, mouse, rat BCAS3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BCAS3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAS3 Predesigned siRNA for gene silencing in human, mouse, rat BCAS3
     QuantiFast Probe-based Assays in human, mouse, rat BCAS3 QuantiTect SYBR Green Assays in human, mouse, rat BCAS3
     Custom PCR Arrays for BCAS3 Search Chromatin IP Primers for BCAS3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAS3  GeneGlobe Interaction Network for BCAS3
     Regulatory tfbs in BCAS3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BCAS3 GenScript cDNA clones with any tag delivered in your preferred vector for BCAS3
     GenScript Custom Assay Services for BCAS3 GenScript Custom overexpressing Cell Line Services for BCAS3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BCAS3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BCAS3 antibodies
     BCAS3 proteins
     Antibodies for BCAS3
     See all of Abcam's Antibodies, Kits and Proteins for BCAS3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BCAS3
     Antibodies for BCAS3
     ELISAs for BCAS3
     CLIAs for BCAS3



     Browse ESI BIO Cell Lines and PureStem Progenitors for BCAS3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAS3
     SwitchGear 3'UTR luciferase reporter plasmids for BCAS3
     SwitchGear Promoter luciferase reporter plasmids for BCAS3
     ThermoFisher Antibodies for BCAS3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAS3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCAS3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCAS3
     LSBio Antibodies in human, mouse, rat for BCAS3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCAS3 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4